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Previous DOE Studies
Under the original Memorandum of Understanding (MOU), NIOSH assumed responsibility for
the management of a number of on-going studies, then being conducted by four contractors of
the Department of Energy [Oak Ridge Associated Universities (ORAU), which became the Oak
Ridge Institute for Science and Education (ORISE), Los Alamos National Laboratory (LANL),
(Battelle Pacific Northwest Laboratory (PNL) and Hanford Environmental Health Foundation
(HEHF)]. Approximately 40 research efforts were itemized in the MOU. Several of these,
however, were completed prior to the actual transfer of the studies, or were duplicate citings of
the same research project. Ten projects being performed by ORISE, five by LANL, and five by
HEHF/PNL were actually transferred for management by NIOSH. In most of these cases, the
research efforts were well under way by the time of the implementation of the MOU; therefore,
there was minimal opportunity for NIOSH to provide scientific or technical input. NIOSH
worked with these contractors toward the completion of all of these research endeavors. A brief
summary of the report generated for each is provided below:
I. OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION (ORISE)
The following studies were performed by investigators from the Center for
Epidemiologic Research of ORISE, under the leadership of Donna Cragle, Ph.D. The
analysis of the studies of two sites, X-10 and Y-12, were conducted by investigators from
the University of North Carolina, as a sub-contract to ORAU.
1. Oak Ridge National Laboratory (X-10)
Manuscript: Wing S, Shy C, et al: Mortality among workers at Oak Ridge
National Laboratory. J Amer Med Assoc 265(11): 1397-1402,
1991.
Summary: White males hired at the Oak Ridge National Laboratory between
1943 and 1972 were followed up for vital status through 1984
(N=8318). Relatively low mortality compared with that in US
white males was observed for most causes of death. However,
leukemia mortality was elevated in the total cohort (63% higher, 28
deaths) and in workers who had at some time been monitored for
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External radiation with a 20-year exposure lag was related to all
causes of death (2.68%, increase per 10 mSv), primarily due to an
association with cancer mortality (4.94%, per 10 mSv).
Manuscript: Shy C, Wing S: A report on mortality among workers at Oak
Ridge National Laboratory: Follow-up through 1990. Draft Final
Report, March 31,1994.
Summary: This is a follow-up of the mortality experience of the cohort of
white males employed at the ORNL, originally described in 1991
(see above). An additional 586 deaths were identified (compared
with 1524 deaths in the original follow-up). The all-cause SMR,
the all-cancer SMR, and lung cancer SMR were all unchanged
from the previous update; however, the leukemia SMR was 1.35,
as compared with 1.63. The SMR for leukemia does decline to
0.71 for the recent follow-up years (1985-1990), possibly reflective
of a leukemia-radiation association due to relatively high doses in
the 1940s and 1950s.
2. Y-12 Plant, Oak Ridge
Manuscript: Loomis D, Wolf S: Mortality of Workers at a Nuclear Materials
Production Plant in Oak Ridge, Tennessee, 1947-1990. American
Journal of Industrial Medicine, 29:131-141, 1996.
Summary: The mortality experience of a cohort of 10,597 males and females
who worked at Y-12 between~f947 and 1974 was somewhat lower
than that of the United States population, and cancer mortality was
equal to that of the general population. Deaths from lung cancer
were significantly elevated (SMR=1.17, 95% CI=1.01, 1.34).
There was also a small excess of brain and lymphatic cancer
(SMRs=1.13 and 1.32, respectively). A small increase in
pancreatic cancer deaths was also noted (SMR=1.36).
3. Oak Ridge Gaseous Diffusion Plant (K-25)
Manuscript: Dupree E, Watkins J, et al: Uranium dust exposure and lung cancer
risk in four uranium processing operations. Epidemiology 6(4):
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Summary: Mortality patterns among 35,712 workers ever employed for 30
days or more at K-25 between 1943 and 1984 was investigated.
For white males, the SMR for all causes of death was significantly
elevated (SMR=1.03, CI=1.01,1.05). Other statistically
significant increases among the white male population included
cancers of the respiratory system including lung cancer, cancer of
the bone, mental disorders, and respiratory diseases, and all
accidents. Among nonwhite males, no cause of death showed a
statistically significant increase.
4. Combined Oak Ridge Facilities (Tennessee Eastman Corporation [TEC], Y-12,
X-10, K-25) (ORFCOM)
Manuscript: Watkins J, Cragle D, Frome E: Collection, validation, and
treatment of data for mortality study of nuclear industry workers.
Appl Occup Environ Hyg 12:195-205,1997.
Summary: This paper describes methodologic issues related to combining
facilities at Oak Ridge Operations in Tennessee. It includes
evaluation of 118,5 88 workers employed at TEC, Y-12, K-25, or
X-10. Discussed are issues of validation and treatment of data for
study members, and characteristics of their radiation exposure.
Manuscript: Frome E, Cragle D, et al: A mortality study of employees of the
nuclear industry in Oak Ridge, Tennessee. Radiation Res. 148: 64-
80, 1997.
Summary: An analysis was conducted oT2T,982 "deaths occurring among
106,020 persons employed for at least thirty days at four nuclear
facilities in Oak Ridge, Tennessee (TEC, Y-12 (after 1947), X-10,
or K-25) between 1943 and 1983. Overall mortality and overall
cancer mortality estimates were in close agreement with national
rates. The only notable excesses occurred for lung cancer
(SMR=1.18) and nonmalignant respiratory disease (SMR=1.12)
among white males. Analysis showed that workers employed at
TEC, K-25, and multiple facilities had higher death rates than
similar workers employed only at X-10 and Y-12. These
elevations were due to differences among the facilities for lung
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5. Welders at Oak Ridge Facilities
Manuscript: Wells S, Cragle D, et al: An update of mortality among welders,
including a group exposed to nickel oxides. Final Report, Oak
Ridge Associated Universities, Document 98-0790. National
Technical Information Services.
Summary: Overall mortality and all causes of death were examined among
1,211 white male welders employed at three DOE facilities in Oak
Ridge, from 1943 through 1989. There was a slight excess in
emphysema deaths in the overall cohort, and a slight excess of
deaths from diseases of the respiratory system among workers
exposed to nickel oxides. The SMR for lung cancer in the total
cohort also reached statistical significance (SMR=1.38, CI=1.03-
1.82). Elevations in deaths due to ulcers and prostate cancer were
also noted among workers exposed to nickel oxides.
6. Uranium Case-Control Study (TEC, Y-12, Fernald, Mallinckrodt)
Manuscript: Dupree E, Watkins J, et al: Uranium dust exposure and lung
cancer risk in four uranium processing operations. Epidemiology
6(4): 370-375, 1995.
Summary: This study sought to examine the relationship between uranium
dust exposure and lung cancer mortality among workers employed
in four uranium processing or fabrication operations located in
Missouri, Ohio, and Tennessee. A total of 787 cases was
identified. Odds ratios for lung cancer mortality for seven
cumulative internal dose groups did not demonstrate increasing
risk with increasing dose. However, there was a suggestion of an
exposure effect for workers hired at age 45 years or older. Further
analyses for cumulative external dose and exposures to thorium,
radium, and radon did not reveal any clear association between
exposure and increased risk, nor did categorizing workers by
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7. 5 Rem Study (multiple facilities)
Manuscript: Fry S, Dupree E, Sipe D, et al: A study of mortality and morbidity
among persons occupationally exposed to 2 50 mSv in a year:
Phase I, mortality through 1984. Appl Occup Environ Hyg 11(4):
334-343,1996.
Summary: This study investigated the mortality experience of 3145
individuals who reportedly received 2 50 mSv of penetrating
ionizing radiation in any calendar year of employment (1943
through 1978) at all facilities operated for DOE. 588 deaths (19%)
occurred. The overall mortality experience of the total white male
cohort was consistent with a healthy worker effect. SMRs for all
causes of death, as well as diseases of the circulatory and digestive
systems, were significantly decreased. SMRs were elevated for
cancers of the esophagus and rectum, for lymphosarcoma, and for
benign neoplasms; however, there were no statistically significant
differences in mortality due to these causes or due to cancers of
any of the major organ systems.
II. LOS ALAMOS NATIONAL LABORATORY (LANL)
The following five studies were performed by investigators at Los Alamos National
Laboratory (principal epidemiologist: Laurie Wiggs, Ph.D.).
1. Mound Plant, Miamisburg, Ohio
Manuscript: Reyes M, et al: Mortality among workers at the Mound facility: a
preliminary report. Los Alamos Technical Report, April 1991.
Summary: This paper reports an investigation of 4697 white males employed
at least 30 days between 1943 and 1979. No statistically
significant elevations were found for the overall cohort. However.
SMRs for thyroid, pharyngeal, lung, and prostate cancers were
above 1.0. Significant elevations in lung cancer were found among
polonium workers employed between 1943 and 1959. .Among
workers employed for less than two years between 1943 and 1959,
significant elevations were found for all causes, lung cancer and
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Manuscript: Wiggs L, et al: Mortality among workers exposed to external
ionizing radiation at a nuclear facility in Ohio. J Occup Med
33(5): 632-637,1991.
Summary: This study investigated 4182 white males employed between 1947
and 1979. No statistically significant elevations for overall
mortality or site-specific cancers were noted. A subcohort of 3229
workers were monitored for external radiation. This subcohort was
assessed for possible dose-response relationships between
mortality from various causes and external exposure to ionizing
radiation. No statistical differences in mortality were observed
between workers exppsed to ionizing radiation and unexposed
workers. However, among workers exposed to external radiation,
a statistically significant dose-response relationship was seen for
lymphopoietic/hemotopoietic cancers and for all leukemias:
Manuscript: Wiggs L, et al: Mortality among a cohort of workers monitored for
210Po exposure: 1944-1972. Health Physics 61(1): 71-76,1991.
Summary: This study investigated mortality patterns among 2,181 white
males employed between 1944 and 1972, years in which
polonium-210 was processed and urine monitoring was in place.
All causes mortality was less than 1.0. SMRs for cancers of the
thyroid, rectum, esophagus, lymphatic system, oral cavity, and
lung were elevated, though not significantly. Elevated SMRs were
seen for lung cancer among workers employed during WWII, but
not for the post-WWII group. No dose-response relationship was
noted between mortality and exposure to internal radiation.
2. Los Alamos National Laboratory (LANL)
Manuscript: Wiggs L, Johnson E, et al: Mortality through 1990 among white
male workers at the Los Alamos National Laboratory: Considering
exposures to plutonium and external ionizing radiation. Health
Physics 67(6): 577-588, 1991.
Summary: A cohort mortality study was conducted of 15,727 white males
employed at LANL from 1943 to 1977. No cause of death was
elevated among this cohort. Mortality from all causes of death and
all cancers was significantly low, as was mortality from many
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conducted for a subcohort of workers first employed during WWII.
The SMRs for the WWII subcohort indicated mortality in this
subcohort was also low compared with the general population. No
cause of death was significantly elevated. Analyses of mortality
comparing plutonium-exposed and unexposed workers considering
a 10-year induction period also showed that no cause of death was
significantly elevated. However, dose-response relationships were
observed for cumulative dose of external ionizing radiation and
cancers of the brain/central nervous system, esophagus, and
Hodgkin's disease.
3. Rocky Flats Nuclear Weapons Plant, Golden, Colorado
Manuscript: Wilkinson GS, Tietjen GL, Wiggs LD, et al: Mortality among
plutonium and other radiation workers at a plutonium weapons
facility. Amer J Epidemiol 125 (2): 231-250, 1987.
Summary: Mortality patterns were examined for 5413 white males employed
for at least two years at the Rocky Flats Plant from 1952 through
1979. Fewer than expected deaths were observed for all causes, all
cancers, and lung cancer. An excess of brain cancer was found for
the overall cohort. Elevated rate ratios (RRs) for all causes of
death and all lymphopoietic cancers were found, when comparing
workers with plutonium burdens of ^2 nCi with those with body
burdens < 2 nCi. Increased RRs were also observed for
esophageal, stomach, colon, and prostate cancers, as well as
lymphosarcomas and reticulumcell sarcomas. Comparing workers
with rem with those with < 1 rem cumulative exposure, several
elevated RRs were observed (myeloid leukemia, lymphosarcomas
and reticulum cell sarcomas, liver neoplasm, and unspecified brain
tumors). No overall dose-response relationships were found for
either plutonium or external radiation exposure.
4. Zia Company, Los Alamos, New Mexico
Manuscript: Galke W, Johnson E, et al: Mortality in an ethnically diverse
radiation exposed occupational cohort, Draft Final Report.
November 24, 1992.
Summary7:
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monitored for exposure to either plutonium or external ionizing
radiation were included in this retrospective cohort mortality study.
Among males, significantly elevated SMRs were seen for stomach
cancer, senility and ill-defined conditions, all injuries, all
accidents, and motor vehicle accidents. SMRs for females were
consistent with mortality rates in the general population. Hispanic
males, however, had significantly higher mortality from stomach
cancer, all injuries, all accidents, and motor vehicle accidents.
Non-Hispanic males had significantly higher mortality from all
causes, all cancers, lung cancer, all circulatory diseases, and all
respiratory diseases. Stratified rate ratio analyses were conducted
to test the association between radiation exposure and mortality.
No significantly high RRs were seen in either Hispanic or non-
Hispanic males in the plutonium or external ionizing radiation
analyses.
5. Plutonium Workers (LANL, Zia)
Manuscript: Voelz G, Johnson E, et al: Mortality of 224 male workers exposed
to plutonium. Draft Final Report, February 9, 1993.
Summary: This paper describes an updated mortality study of a group of
workers exposed to plutonium at the LANL and Zia. Study
subjects were selected by searching the Los Alamos plutonium
dosimetry records for all workers who were estimated to have
plutonium depositions over 370 Bq. Two types of mortality
analyses were performed: lJ'SMRs (calculated as of 1990) based
on morality rates of white males in the U.S. general population,
and 2) mortality RRs to compare deaths occurring in the 224
exposed group with those in an unexposed comparison group. The
SMRs for all malignant neoplasms were below 1.0. Only the SMR
for bone cancer was elevated (SMR=10.6, CI=0.15, 59), though
this is based on only one case. All mortality RRs were calculated
with a 10-year cancer induction time. The ratios for all causes of
death and all malignant neoplasms were not significantly elevated.
Only the SRR for digestive system cancer was above 1.0
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ffl. HANFORD ENVIRONMENTAL HEALTH FOUNDATION (HEHF)
BATTELLE PACIFIC NORTHWEST LABORATORIES (PNL)
Several research projects were performed jointly by investigators at the Hanford
Environmental Health Foundation (HEHF) (principal epidemiologist: Ellen Omohundro,
Ph.D.) and Battelle Pacific Northwest Laboratories (PNL) (principal investigator: Ethel
Gilbert, Ph.D.). HEHF was responsible for the collection and verification of mortality,
occupational history, and medical and personal health history data. PNL gathered
radiation dosimetry data and was responsible for data integration and analysis. With the
exception of the combined studies, all the research efforts by these contractors pertained
to the Hanford Site.
1. Hanford Site, Richland, Washington
Manuscript: Gilbert E, Omohundro E, et al: Mortality of workers at the
Hanford Site: 1945-1986. Health Physics 64(6): 577-590,1993.
Summary: This study investigated mortality among contractor employees
initially employed at the Hanford site from 1944-1978. Both the
SMR for overall mortality and mortality from malignant neoplasms
for all workers were below 1.0. SMRs for diseases of the
musculoskeletal system among all workers, for cancer of the
pancreas in males not monitored for external radiation, and for all
other solid tumors in males not monitored for external radiation
were elevated, but not significantly. Comparisons of death rates by
radiation dose within the cohort showed no evidence of a
correlation for all causes of death", all cancers, or leukemia with
radiation dose. Cancer of the pancreas (p=0.07) and Hodgkin's
disease (p=0.04) showed positive correlations with radiation dose.
However, these correlations are regarded as spurious. Of note is
the fact that rates of multiple myeloma deaths in this cohort
continue to be elevated.
Manuscript: Omohundro E, Gilbert E: An evaluation of the adequacy of vital
status follow-up in the Hanford Worker Mortality Study. PNL
Technical Report (PNL-8981), November 1993.
Summary: This report was designed to evaluate the completeness of vital
status ascertainment in the Hanford worker cohort. Identifying
information on 17,708 Hanford workers was submitted to Equifax
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Equifax ascertained only 12 new deaths. In order to evaluate the
adequacy of the methods used by Equifax, information on 2,254
Hanford workers who had been previously identified as dead was
also submitted. Equifax missed less than 2% of known Hanford
deaths occurring in the period 1965-86, but missed about 18% of
deaths occurring before 1965. For the period 1987-89, Equifax
identified 49 new deaths. A stratified random sample of 1,600 of
the 17,708 workers with unknown vital status was submitted to
Equifax for a more extensive investigation of follow-up status.
Information on these workers was compared against consumer
credit databases to determine the last date these workers were
known to be alive. The results of this part of the study indicate that
if these procedures had been applied to all workers with unknown
vital status, about 90% of these workers would have been
confirmed to be alive. About 5% of the total study population
would have remained lost to follow-up.
2. Combined U.S. Cohorts (Hanford, ORNL, Rocky Flats)
Manuscript: Gilbert E, Cragle D et al: Updated analyses of combined mortality
data on workers at the Hanford Site, Oak Ridge National
Laboratory, and Rocky Flats Nuclear Weapons Plant. Radiation
Res 136: 408-21,1993.
Summary: 44,943 workers from Hanford, ORNL (X-10), and Rocky Flats
were studied for a direct assessment of health risks resulting from
protracted low-dose exposure to ionizing radiation. Of 24 cancer
types tested, 12 showed positive correlations with radiation dose
and 12 showed negative correlations. Cancer of the esophagus,
cancer of the larynx, and Hodgkin's disease showed statistically
significant correlations with radiation dose, but these correlations
were interpreted as likely to have resulted from bias or chance
fluctuations. Evidence of an increase in the excess relative risk
with increasing age at risk was found for all cancer in both Hanford
and ORNL, and both populations showed significant correlations
of all cancer with radiation dose among those 75 years and older.
Although this age effect may have resulted from bias in the data,
its presence suggests that risk estimates based on nuclear worker
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3. Combined International Studies (U.S., Canada, U.K.)
Manuscript: Cardis E, Gilbert E, et al: Effects of low dose and low dose
rates of external ionizing radiation:Cancer mortality among
nuclear industry workers in three countries. Radiation Res
142: 117-132,1995.
Summary: This paper presents the results of combined analyses of
mortality data on 95,673 workers monitored for external
exposure to ionizing radiation and employed for 6 months
or longer in the nuclear industry in three countries. There
was no evidence of an association between radiation dose
and mortality from all causes or from all cancers. Mortality
from leukemia, excluding chronic lymphocytic leukemia,
showed a statistically significant association with
cumulative external radiation dose. Among 31 other
specific types of cancer studied, a statistically significant
association was observed only for multiple myeloma, and
this was attributable primarily to the associations reported
previously between this disease and radiation dose in the
Hanford and Sellafield cohorts. The relative risk of all
cancers excluding leukemia was 0.99, and 1.22 for
leukemia excluding CLL for a cumulative protracted dose
of 100 mSv compared to 0 mSv.
IV. MALLINCKRODT CHEMICAL WORKS
Manuscript: Dupree Ellis E, Watkins JP, Ingle JN, Phillips JA: External
Radiation Exposure and Mortality Among a Cohort of Uranium
Processing Workers. Final Report to NIOSH, September 1998;
also presented at the American College of Epidemiology Annual
Meeting, September 1998.
Summary: This study investigated 2514 white males employed in a uranium
processing plant between 1942 and 1966. Through 1993, 1056
deaths were ascertained. The SMR for all causes was 0.92 (95%
CI, 0.86 - 0.97) and 1.10 (0.98-1.23) for all cancers. Respiratory
diseases, chronic nephritis, and lymphatic cancers were
significantly elevated. Trend tests revealed a statistically
significant increase of kidney cancers with external radiation based
on 11 deaths with a 12.9% increase in relative risk per 10 mSv of
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since external radiation exposure may be a surrogate for internal
radiation dose or chemical exposures which were not considered in
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Completed NIOSH-Initiated Research
1. Multi-Site Multiple Myeloma Case-Control Study
Contractor: University of North Carolina (Steven Wing, Ph.D.)
Award Period: 10/1/93 - 3/28/97
Summary: This multi-site case-control study evaluated possible etiologic risk
factors, focusing on external radiation and chemical exposures.
Five sites were included: Savannah River, Los Alamos National
Laboratory (LANL), LANL-Zia, Oak Ridge National Laboratory,
and Hanford. The final report, study files, and supporting data,
have been provided to NIOSH. External penetrating radiation
doses received at age 45 and above were found to be associated
with multiple myeloma. Study results were presented to labor and
management.
Significance: confirmation of earlier observation of radiation induced multiple
myeloma; shape of dose-response defined; complements leukemia
case-control study being done at same sites and multiple myeloma
case-control study with internal radiation exposure at the Oak
Ridge Gaseous Diffusion Plant (K-25); suggests the importance of
age at exposure as possible important variable in ionizing radiation
studies.
Total Cost: $904,000
Mercury Workers Health Study
Contractor: Oak Ridge Associated Universities (Donna Cragle, Ph.D.)
Award Period: 10/1/93 - 11/30/96
Summary: This is a follow-up study of neurologic health outcomes in 219
workers exposed to high levels of elemental mercury at the Y-12
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been notified individually of their test results, and the final report
has been received by NIOSH. Neurologic effects of relatively
heavy exposure to mercury were still detectable more than 30 years
after cessation of exposure. The adverse effects were observed
primarily for the peripheral nervous system (by both clinical
examination and electrodiagnostic evaluation). Postural tremor
was also associated with past mercury exposure. The study results
were presented to a labor-management group in April 1997, and a
technical report was prepared for NIOSH at the end of the study.
Significance: Morbidity study; non-cancer effect; chemical exposure; follow-up
of previous group; applicable to surveillance.
Total Cost: 5731,0003.
3. Historical Plutonium Bioassay Measurements
Contractor:
Award Period:
New York University (Norman Cohen, Ph.D.)
10/1/93-12/31/95
Summary: This research evaluated the bias, uncertainty, and selectivity of
plutonium bioassay procedures used by DOE over time, since they
may affect the retrospective dosimetry of plutonium workers. The
research has been completed but, due to the illness of the Principal
Investigator, the final report was not submitted.
Significance: Uncertainty analysis; needed for internal exposure assessment of
plutonium.
Total Costs: $445,700
4. Accounting for Errors in Radiation Dose Estimates
Grantee: Battelle Pacific Northwest Laboratories (Ethel Gilbert, Ph.D.)
Award Period: 10/1/94-9/29/96
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uncertainties in estimates of cumulative external dose and applied
the model to Hanford data. This grant has been completed. A
manuscript summarizing the findings has been published (Gilbert
et al: Health Physics 70 (3): 336-345,1996).
Significance: Uncertainty analysis; accounting for bias in external dose estimates
Total Cost: $ 131,000
5. Cohort Mortality Study of Portsmouth Gaseous Diffusion Plant (PORTS), Piketon,
Ohio
Investigator:
Study Period:
Summary:
Significance:
NIOSH intramural study (Project Officer: Robert Rinsky, Ph.D.)
2/1/92 - 12/31/96
The mortality of workers at PGDP was updated through 1992.
Radiation exposure assessments were performed for internal and
external ionizing radiation, certain chemicals, and electromagnetic
fields. No significantly elevated standardized mortality ratios
(SMRs) were observed for overall or specific causes of death.
Case-control analyses of lung, lymphoma, hematopoietic, and
stomach cancers and exposures to internal soluble alpha dose,
flourines, nickel, and uranium were done. These results are being
prepared for presentation to labor and management.
Congressional request; lung cancer and role of confounders;
enhanced exposure assessment for chemical and radiation doses;
continued surveillance of a worker population previously studied.
Total Cost:
5498,000
6. Feasibility Study of Assessing Adverse Reproductive Outcomes Among Females
Employed at DOE Facilities
Investigator: NIOSH intramural study (Project Officer: Barbara Massoudi,
Ph.D.)
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Summary: The feasibility of conducting an epidemiologic study of adverse
reproductive outcomes among females employed at DOE is
dependent upon four factors: availability of an appropriate study
population; a valid case definition and means of ascertainment;
exposure to the agent(s) in question and sufficient data to
characterize such exposure; and, adequate sample size to
demonstrate an effect. In order to address these issues, several
sources of data were collected and evaluated by NIOSH
investigators. Data obtained on females employed at 20 sites
previously studied epidemiologically included distributions over
time related to demographic characteristics, radiation monitoring
data, and vital status was examined. Information was collected on
all existing birth defects registries in states in which DOE facilities
are located. This report concluded that the opportunity for an
epidemiologically sound study is not present at this time.
Significance: Non-cancer outcomes; female populations
Total Cost: $10,000
7. Childhood Leukemia Case-Control Study
Awardee: Batelle Laboratories (Lowell Sever, Ph.D.)
Award Period: 9/29/92-3/31/97
Summary: This case-control study assessed the potential association between
paternal exposure to ionizing radiation and risk of leukemia in
offspring, a finding observed in Sellafield, England by Gardner et
al. (1990). The study follows up on previous findings of birth
defects (CNS tumors) at Hanford. The study, initiated at the
Hanford Site, was expanded to Oak Ridge and Idaho, and included
non-Hodgkin's lymphoma and central nervous system (CNS)
tumors as outcomes. The study found no evidence of a link
between childhood cancer risk and father's radiation work at the
Department of Energy sites included in the study. This finding did
not change if each site was looked at alone or all together. There
was also a much weaker finding which relates only to Hanford
children. Children whose fathers worked at Hanford were more
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other sites. However, this finding was not statistically significant
and was based on small numbers. The study was completed in
November 1997; the report and findings went under external peer
review with final communication of results to workers and
management at the sites studied in October 1998.
Significance: Three other studies since the Sellafield study have not shown an
increase in childhood cancers among children with fathers exposed
to radiation prior to their child's conception. This NIOSH
sponsored study agrees and supports those study findings.
Total Cost: S750,000
8. Time-Related Factors in Radiation-Cancer Dose Response
Grantee: University of North Carolina (Steven Wing, Ph.D.; David
Richardson, Ph.D.)
Award Period: 10/1/96 - 9/30/97
Summary: This study expanded, updated and re-analyzed a cohort of workers
at the Oak Ridge National Laboratory, that was originally analyzed
by Checkoway. The cohort included persons employed at ORNL
between 1943 and 1972. Special emphasis was given to the
relationships with radiation and cancer, and certain time related
factors such as age-at-exposure, latency, and time-since-exposure.
There was evidence of a stronger dose response relationship
between exposures to cumulative dose received at older ages.
Significance: Dose received after age 45 is strongly predictive of all-cancer-
combined mortality as well as lung cancer; implications for future
occupational epidemiologic research and exposure standards.
Total Cost: 5150,000
9. Dose Estimation from Daily and Weekly Dosimetry Data
Grantee:
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Award Period:
Summary:
Significance:
10/01/98 - 09/30/98
Statistical methods were used to estimate distributions of external
radiation exposures for workers included in epidemiology studies
of the Oak Ridge National Laboratory. The method took into
account measurement errors from film badge and pocket meter
systems, from recording left-censored doses as zeros, and from
other practices and policies. The amount of bias in previously used
estimates of exposure was substantial although incorporation of the
daily pocket chamber readings reduced uncertainty in some
estimates but increased it in others.
Exposure assessment methods development; uncertainty analysis
for external radiation exposure estimates used in previous and
current studies of workers at Oak Ridge National Laboratory:
Total Costs:
$149,000
10. Cohort Mortality Study of Workers at Fernald Feed Materials Production Center
Contractor:
Award Period:
Oak Ridge Associated Universities
Donna Cragle, Ph.D.
1992-1997
Summarv:
Significance:
Mortality patterns were examined for 4,014 white males at the
Femald Feed Materials Production Center between 1951 and 1981.
Vital status ascertainment was through 1989 and 1,064 deaths were
included in the study. Exposure estimates were developed for
internal and external ionizing radiation. Although salaried workers
showed a healthy worker effect, a significant increase for stomach
cancer deaths was found. Hourly workers did not demonstrate a
healthy worker effect and excess mortality was noted for all
cancers, lung cancer, and motor vehicle accidents. These findings
were produced without controlling for other lung carcinogens that
were likely present in the work environment such as radon and
other chemicals. A draft final report was prepared for NIOSH in
1996.
Cohort mortality study; previously unstudied cohort; included
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exposure assessment for internal and external radiation;
complements studies conducted at Mallinckrodt.
Total Costs: Transferred study
11. Cohort Mortality Study of Workers at Savannah River Plant
Contractor:
Award Period:
Summary:
Significance:
Oak Ridge Associated Universities
Donna Cragle, Ph.D.
1992 - 1997
This study was conducted for 9,757 white male workers at the
Savannah River Site employed between 1952 and 1974. Vital
status follow-up through the end of 1989 ascertained 1,722 deaths
among the cohort. A strong healthy-worker effect was noted.
Dose-response analyses were performed for all cancers, leukemia,
and lung, colon, and pancreatic cancers. A significant positive
dose-response relationship was observed for external radiation and
leukemia mortality with a 7.81 percent increased risk per 10
milliSieverts with a two-year lag using a multiplicative relative
risk model, and 18.28 percent using an excess relative risk model.
A draft final report was prepared for NIOSH in 1996.
Exposure assessment for internal and external radiation; significant
dose-response for leukemia; cohort included in leukemia case-
control study
Total Costs:
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Ongoing Research
INTRAMURAL RESEARCH
1. Portsmouth Gaseous Diffusion Plant (PORTS) Nested Case-Control
Studies, Piketon, Ohio
Project Officer:
Study Period:
Summary:
Significance:
Robert Rinsky, Ph.D.
1/1/97 -12/31/98
In follow-up to the completed cohort analyses (see
Completed Studies), case-control analyses were
performed for lung, stomach, and hematopoietic cancers
to investigate possible dose-response relationships,
because of undocumented neutron exposure and the
many confounders present at the facility. It is
considered unlikely that additional study of this facility
would result in further understanding of the dose
response relationship due to mixed radiologic and
chemical exposures. These analyses are expected to be
complete by 1998.
Congressional request; more data on lung cancer and
external radiation exposure; role of confounders;
continued surveillance.
Annual Budgets: FY98: $61,000 FY99: S2,000 FY00: SO
Projected Total: $220,000
*Projected FY99 funds to support notification efforts
Cohort Mortality Study of Idaho National Engineering and
Environmental Laboratory (INEEL)
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Study Period:
Summary:
Significance:
10/1/92 - 6/30/99
An all-cause cohort mortality study is underway at
INEEL, a previously unstudied site. Exposures of
interest are external ionizing radiation and a variety of
chemicals. More than 70,000 workers have been
employed at this site. The first phase of the study
(SMR analysis) is planned for completion by June
1999.
Governor's request, Congressional interest; previously
unstudied site;'data will be used in other studies, i.e.,
IARC study of nuclear workers, childhood leukemia
Annual Budgets: FY98: S352,300 FY99: S469,000 FY00: $67,000.
Projected Total: S3,433,100
*Projected FY99 funds includes possible case-control studies.
3. Cohort Mortality Study of Portsmouth Naval Shipyard (PNS), Kittery,
Maine
Project Officer:
Study Period:
Summarv:
Significance:
Robert Rinsky, Ph.D.
10/1/93 - 9/30/99
The mortality study of civilian employees at PNS is
being updated through 1996. The cohort has been
expanded to include all workers employed through
1992. Naval Sea Systems Command will provide
access to records and facilities. Case-control studies
will also be done, as indicated by the SMR analysis.
Exposure to external ionizing radiation almost
exclusively; study supported by US Navy; data will be
used in other studies, i.e., NIOSH leukemia case-control
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Annual Budgets: FY98: $232,000 FY99: $238,600 FYO0:O
Projected Total: $874,000
4. Leukemia Case-Control Study
Project Officer:
Study Period:
Summary:
Thurman Wenzl, Sc.D.
7/1/95-12/31/99
This multi-site case-control study will explore the
relationship between external radiation and leukemia
risk. About 250 leukemia deaths will be identified at
five DOE sites and PNS when the vital status is updated
through 1996. Confounding exposures to internal
radiation, chemicals and EMF will be evaluated for all
cases and controls. Expected date of completion is
December 1999.
Follow-up to recent positive findings of leukemia and
radiation in cohort studies; largest study of its kind ever
done; study design allows control of confounders;
companion to study of multiple myeloma
(hematopoietic cancer, also) at same sites; includes
update of vital status of Hanford and Savannah River
cohorts
Annual Budgets: FY98: 5394,700 FY99: $525,000 FY00: $274,000
Projected Total: $1,468,500
Significance:
5. Multiple Myeloma Case-Control Study at the Oak Ridge Gaseous
Diffusion Plant (K-25)
Project Officer: M. Kathrvn Brown, Ph.D.
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Summary: This case-control study of multiple myeloma deaths
among workers at the Oak Ridge (K-25) gaseous
diffusion plant addresses the exposures to internal
ionizing radiation and chemicals. This study
complements the multi-site, multiple myeloma study
recently completed by the University of North Carolina
which addressed exposures to external ionizing
radiation. Currently, the vital status of the K-25 cohort
is being updated through 1996.
Significance: This is the largest single-site study of multiple
myeloma; the relatively large number of cases provides
reasonable statistical power to evaluate a dose-response
relationship. Potential confounders will be evaluated.
Annual Budgets: FY98: S281.300 FY99: $289,800 FY00: SO
Projected Total: SI,177,400
Exposure Assessment of Hazardous Waste, Decontamination and
Decommissioning, and Clean-up Workers - Phase I
Project Officer: Steven Ahrenholz, Ph.D.
Study Period: 5/1/96 - 10/31/99
Summarv:
Significance:
Exposures encountered by hazardous waste, clean-up,
and decontamination and decommissioning workers
will be characterized. In Phase I, background
information will be collected at seven DOE sites to
assess working conditions, and to identify issues and
research needs at the sites. This phase had been
proposed to be completed by late 1998; however, access
problems threaten to delay this completion date.
Addresses exposures to current workers; assesses
feasibility of tracking workforce for future studies;
evaluates mixed exposures; supports surveillance
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Annual Budgets: FY98: $370,300 FY99: $400,000 FYOO: $0
Projected Total: $1,246,200
7. Cohort Mortality Study of DOE Chemical Laboratory Workers
Project Officers:
Study Period:
Summary:
Significance:
Cynthia Robinson, Ph.D.
10/1/96 - 9/30/99
In limited studies of chemical laboratory workers, an
increased risk of all cancers and several specific cancers
has been found. A mortality study of DOE chemical
laboratory workers is feasible using available data sets.
A draft protocol has been prepared, and data sets are
being collected. An SMR analysis can be completed by
March 1999.
Addresses hazards that are applicable outside the DOE
complex; chemical exposures; female workers; mixed
exposures
Annual Budgets: FY98: $290,800 FY99: $388,000 FYOO: $0
Projected Total: $774,800
8. Cohort Mortality Study of Pantex Plant, Amarillo, Texas
Project Officer: Barbara Grajewski, Ph.D.
Study Period: 10/1/96 - 9/30/99
Summary: A study of Pantex workers published in 1985 was
limited by the small number of deaths and short follow-
up, although the risk of several cancers was elevated.
Vital status was updated through 1995 and an SMR
analysis was conducted. The cohort was also evaluated
by statistical modeling to look for any dose response
effects. A final report is being prepared and findings
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Significance: Plant is not being downsized; although mission has
changed, similar exposures will be encountered by
current and future workers; addresses suggestive
findings of original study
Annual Budgets: FY98: 5337,600 FY99: $450,000 FY 00: $0
Projected Total: 5760,500
9. Lung Cancer Case-Control Study
Project Officer: Barbara Grajewski, Ph.D.
Study Period: 9/30/97 - 9/29/00
Summary:
Significance:
Five recent epidemiologic studies have shown a dose-
response relationship between lung cancer and external
ionizing radiation. These studies, however, have had
potentially confounding exposures to known lung
carcinogens. This project will investigate the
association of mortality from lung cancer and exposure
to external ionizing radiation among DOE workers.
Sites were selected to target workers primarily exposed
to external radiation and include those involved in
reactor operations. The sites identified include Hanford
(Area 100), Savannah River (Area 100), Oak Ridge
National Laboratory (X-10), and the Idaho National
Engineering and Environmental Laboratory.
Follow-up on results of previous studies that were
limited by lack of internal dose data and control of
confounders
Annual Budgets: FY98: S290.800 FY99: 5388,000 FY00:5401,000
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10. Construction Mortality Study
Project Officer: Cynthia Robinson, Ph.D.
Study Period:
10/1/97 - 9/30/00
Summary:
This all-cause retrospective cohort mortality study of
former DOE construction workers provides an
opportunity to further define the risks associated with
asbestors fibers, silica-containing dusts, beryllium
particulates, arid other exposures regularly encountered
by past construction worker.
Significance: Relatively few mortality studies have been conducted
among construction workers; a more stable workforce
at DOE sites than other construction groups;
applicability to present construction workforce.
Annual Budgets: FY98: $224,700 FY99: $299,000 FY00: $271,000
Projected Total: 5816,800
11. Registry for Health and Work Histories Information
Project Officer: Cynthia Robinson, Ph.D.
Study Period: 10/1/97 -9/30/00
Summary:
Current workers involved in the decontamination and
decommissioning (D&D) process underway at Femald
encounter exposures which differ in several ways from
exposures during the production phase. This project
will gather work history, radiologic, industrial hygiene,
and medical data for each worker, including the
subcontractor workers, for entry into a registry. A
report identifying key variables for a surveillance
registry for D&D workers across DOE sites and
evaluating the feasibility of creating this registry will be
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Significance: Requested by The Advisory Committee on Energy-
Related Epidemiologic Research (ACERER); no
established registries that allow identification and
tracking of current and future D & D workers.
Annual Budgets: FY98: 579,900 FY99: $106,000 FY00: $40,000
Projected Total: $248,000
12. Bladder Cancer Incidence Study at K-25 Plant (Oak Ridge Gaseous
Diffusion Plant)
Project Officer:
Study Period:
Summary:
Significance:
Annual Budgets:
Sharon Silver, M.A.
10/01/98-9/30/01
A limited morbidity study of about 1,135 workers at K-
25 showed a significant excess of bladder cancer in
workers potentially exposed to methylene dianiline
(MDA), trichlorethylene, and methylene chloride. The
state cancer registry and other health data sources will
be used to determine whether additional cases of
bladder cancer have occurred in this population. The
feasibility of utilizing biomarkers and of developing
quantitative estimates of worker exposure in the
expanded study will be explored, as will the feasibility
of implementing medical screening for this population.
A study protocol will be developed during FY99.
Assesses worker exposures to potential bladder
carcinogens; determines whether cellular changes can
be used as biomarkers of exposure or effect; evaluates
feasibility of and requirements for medical screening
for bladder cancer.
FY98: $0 FY99: S450,000 FY00: S434,000
0.5 FTE allocated and S50.000 travel and coding
Projected Total:
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13. Cohort Mortality Study of Fernald Environmental Management Plant
(FEMP)
Project Officer:
Project Period:
Summary:
Significance:
Rita Espinoza, MPH
09/01/98 - 09/29/00
This study will update the mortality status of the
workers at Femald through 1996, and will include both
genders and all races. A previous cohort mortality study
examined 4,014 white male workers hired between
1951 and 1981'. Vital status follow-up through the end
of 1989 ascertained 1,064 deaths in this group. A
statistically significant excess of lung cancer mortality
was observed among hourly workers (SMR=1.26), and
a statistically significant excess of stomach cancer
among salaried workers (SMR=2.61). Dose-response
associations were seen between lung cancer and
external radiation exposure, and between nonmalignant
respiratory disease and internal exposure.
Update of previous cohort study (increased latency);
inclusion of groups not yet studied (women and non-
white men).
Annual Budgets: FY98: SO FY99: 5200,000 FY00: $234,000
Projected Total: $434,000
14. Mortality Study of the Zia Cohort, Los Alamos, New Mexico
Project Officer: Travis Kubale, M.S.W.
Studv Period: 01/01/99-12/31/00
Summary:
The Zia cohort is a largely Mexican American
population and presents an opportunity to study the
mortality experience of a population not traditionally
evaluated for their exposure or health risks. A previous
study at the site found that causes of death showing
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males. This study will update the mortality status of the
workers at Zia through 1996 and will further explore
race- and gender-specific differences in causes of
mortality.
Significance: Understudied population (Mexican Americans);
improve understanding of impact of specific exposures
and risks experienced by special populations on
exposure-disease associations; tailor strategic
approaches to public health interventions and
workplace safety standards to specific worker
population.
Annual Budgets: FY98: SO FY99: $110,000 FY00: $0
Projected Total: $110,000
15. Cancer Incidence and Sentinel Event Registries
Project Officer: Rita Espinoza, MPH
Study Period:
Summary:
Significance:
10/01/98- 09/30/00
Across the U.S. a number of cancer incidence and
sentinel event registries have been developed. Many of
these registries are located in areas adjacent to DOE
sites. Using the existing~cancer and sentinel event
registries, this study will identify diseases and disease
groups for further evaluation. Emphasis might be given
to non-fatal diseases which generally elude detection in
traditional epidemiologic mortality studies. These
diseases (1) contribute to the overall ill-health of
current and former workers; or (2) are commonly
associated with the worker populations of interest.
Recommendations for clinic-based intervention trials
and/or public health education activities are a possible
outcome of this research.
Develop resources necessary to observe incident cases
of disease near DOE sites and perform analytical
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of overall morbidity associated with external and
internal radiation exposures.
Annual Budgets: FY98: $0 FY99: $103,000 FY00: 0
Proj ected Total: $ 103,000
16. Cohort Mortality Study of Civilian Nuclear Power Workers' Mortality
Study
Project Officer: Robert Rinsky, Ph.D.
Study Period: 10/01199 - 09/31 /03
Summary: Over 500,000 civilian nuclear utility power plant
workers have been exposed primarily to external
(gamma) ionizing radiation with little to no
concomitant internal dose. This is in contrast to most
DOE nuclear workers who have had mixed exposure to
both internal and external radiation. Average career
external doses for this group have been estimated at
between 2.2 and 4.2 rem, thus providing a wider range
of exposures than does the typical DOE facility.
Additionally, there is a sub-cohort of identifiable
workers with potential neutron exposures. This sub-
cohort offers an opportunity for contrasting the
mortality outcomes between those civilian nuclear
workers with and without neutron exposure. These
exposures have not been successfully separated in the
DOE cohorts.
Significance: Defines dose response relationship for external
exposures; distinguishes risks from external and
internal doses and from gamma and neutron exposures;
largest occupational radiation study of a single
industrial process; will reduce uncertainties about risks
from low-level protracted radiation exposure.
Annual Budgets: FY98: SO FY99: SO FY00: S 1,106,000
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17. Workshop on the Effects of Radiation and Age of Exposure
Project Officer: Robert Rinsky, Ph.D.
Study Period: 10/01/98 - 09/30/99
Summary: Recently, the results of several epidemiological studies
have suggested that age at time of exposure may be an
important consideration in determining the carcinogenic
effects that radiation has on humans. Methods for
statistically modeling this biological effect are not well
defined. A workshop to explore these issues is planned.
The extant scientific literature on the subject and
researchers associated with this work have been
identified. Data for cohorts in which an age at time of..
exposure effect has been reported are being procured or
simulated. Panel members will be asked to develop
new methodologies to identify best statistical models.
Significance: Methods development; could influence standard setting
for radiation protection; applications for long-term
exposures throughout occupational and environmental
epidemiology.
Projected Total: TBD
18. Retrospective Exposure Assessmentjor Workers at the Fernald Plant
Project Officer: Mark Methner, Ph.D.
Study Period: 10/1/99 - 9/30/00
Summary:
At the request of the Femald Health Effects
Subcommittee, NIOSH will conduct a records-based
retrospective exposure assessment at the former Femald
Materials Production Center (FMPC). Records will be
collected and data abstracted and analyzed using
appropriate statistical methods to determine historical
extent of exposure to agents such as radon, asbestos,
uranium dust, and acid mists. A database of relevant
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Significance: Enhance exposure estimates for additional agents for
cohort and case-control analysis; reduced uncertainty
of estimates
Annual Budgets: FY99: $0 FY00: $543,000
Projected Total: TBD
19. Uranium Miners Data Retrieval and Coding
Project Officer: Mark Methner, Ph.D.
Study Period: 10/1/98-9/30/99
Summary:
Significance:
This study involves the review and collection of
recently discovered uranium miner exposure data
located in Salt Lake City, UT. The records consist of
approximately 1760 personal exposure data cards and
computer printouts related to approximately 2000
former uranium miners. All relevant data from these
records will be abstracted, coded and stored into a
database for future retrieval and use by researchers
inside and outside of NIOSH.
Potential validation of lung cancer risk estimates for
radon exposures; radon exposure data for comparison
with previous estimates based on mine location and
type;
Annual Budset: TBD
Projected Total: TBD
20. Exposure Assessment of Radiologic Technologists for Epidemiology
Studies
Project Officer: David Utterback, Ph.D.
Study Period:
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Summary: Radiation exposure estimates will be developed for
epidemiology studies of radiologic technicians being
conducted by the National Cancer Institute (NCI). This
large cohort of radiation exposed workers (>145,000)
began in 1982 and includes case-control incidence
studies for breast, thyroid and lung cancer as well as
leukemia. Survey data have been collected for diet,
smoking status, family history of breast cancer, and
other pertinent information. Radiation exposure records
are incomplete and widely scattered. Use of common
surrogates for exposure, such as duration of
employment or'years certified as a radiologic
technician, have not proved fruitful.
Significance: Collaboration with external partner; mostly female
population; cancer incidence data has been collected.
Annual Budgets: TBD
Projected Total: TBD
*Funds from the National Cancer Institute Radiation Studies Branch
21. Assessment of Electric and Magnetic Field Exposures of Transportation
Workers
Project Officer: Thurman Wenzl, Sc.D.
Study Period: 1/1/96 - 11/30/99
Summary: Electric and magnetic field exposures of workers on
electric trains, on electric buses and at airlines are being
monitored. Preliminary data indicate that maintenance
workers on electric trains may have elevated exposures
to magnetic fields while these exposures for electronic
technicians on municipal electric bus lines were not
elevated.
Significance:
Annual Budgets:
Non-ionizing radiation exposure assessment;
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Projected Total: $360,000
22. Neutron Exposure Assessment in Epidemiology Studies of DOE
Cohorts
Project Officer: Timothy D. Taulbee, B.S.
Study Period:
Summary:
10/1/98-9/30/01
Methods for estimating and independently
incorporating neutron exposure estimates into
epidemiological studies will be developed. Health
effects of neutrons are believed to be dependent on the
magnitude of the cumulative dose, the dose rate and the.
neutron energy spectrum. This study will evaluate
historical neutron monitoring practices and exposures at
several DOE sites. Potential missed dose due to
detector energy thresholds, monitoring frequency and
inadequate monitoring will be evaluated.
Exposure assessment methods development; addresses
biological effectiveness of neutron exposures, mixed
radiation field exposures, and neutron risk estimates
Annual Budgets: FY98: $0 FY99: 5297,000 FY00: 5200,000
Projected Total: 5697,000
Significance:
23. Documentation of Historical Dosimetry Practices at DOE Sites
Project Officer: Steven Ahrenholz, Ph.D.
Study Period: 10/1/98 - 09/30/03
Summary: The uncertainty in risk assessment for radiation
exposures is dependent on the interpretation of
dosimetry' data used in epidemiology studies. This
study will identify, collect, and summarize historical
dosimetry documents at key DOE facilities where
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facilities close or site missions change and personnel
retire, the documents and process knowledge of
historical dosimetry practices are at risk of being
permanently lost.
Significance: Capture of essential information needed to estimate
historical exposures to ionizing radiation; multiple sites;
Annual Budgets: FY98: $0 SFY99: 194,000 FY00: $200,000
Projected Total: $994,000
Ila. EXTRAMURAL RESEARCH (COOPERATIVE AGREEMENTS)
1. Cancer Incidence/Mortality Study of Rocky Flats Plant
Awardee: Colorado Department of Public Health and
Environment (Normie Morin, Ph.D)
Award Period: 9/30/93 - 9/29/99
Summary: Based on the findings of a previous study, a cancer
incidence study was initiated as well as an update of the
mortality study. The dosimetry data for neutrons and
plutonium are being improved. Job exposure matrices
have been completed for chemical exposures and are
being assessed through a field study and expert panel
review. The study roster is complete, follow-up has
been completed, and deaths have been coded. A nested
case control study of lung cancer at Rocky Flats is
being conducted as well. A one-year extension has
been granted for FY-99. Other data collection efforts
continue.
Significance:
Cancer incidence study; reevaluation and upgrade of
dosimetry data benefits DOE and contractor and will
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Annual Budgets: FY98: $349,900 FY99: 5309,000 FY00: $167,000
Projected Total: S3,855,700
2. International Collaborative Study of Nuclear Industry Workers
Awardee:
Award Period:
Summary:
Significance:
International Agency for Research on Cancer (IARC)
(Elisabeth Cardis, Ph.D.)
4/1/95-3/31/99
IARC has undertaken a cancer mortality study of
nuclear workers in 14 countries. Two U.S. cohorts are
included in the study. Vital status and dose data from .
these countries will be combined to increase the power
to quantify small increases in cancer risk in workers
exposed to low doses of ionizing radiation.
Largest study of nuclear workers ever done;
collaboration among 14 countries; collaboration with
WHO/IARC
Annual Budgets: FY98: 530,300 FY99: S39,000 FY00: S49,000
Projected Total: 5220,600
3. Prevention of Stress and Health Consequences of Downsizing and
Reorganization
Awardee: Boston University School of Public Health (Lew
Pepper, M.D.)
Award Period: 9/30/95 - 9/29/00 (with possibility of additional 2 years
to complete intervention research)
Summary: Job stressors, i.e., work-related conditions implicated in
disease development, include job dissatisfaction, lack of
job control, and under-utilization of abilities. Sudden
job change through strike, retirement, layoff, relocation,
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Significance:
project is studying the effects of downsizing on
organizational climate, worker health, and performance.
Significant access problems have arisen which threaten
to impair the ability to complete this study as designed,
and within the originally projected time frame and
budget.
A morbidity incidence study; applicable to current and
future workers; evaluation of interventions; applicable
to surveillance
Annual Budgets: FY98: 5381,600 FY99: 5492,000 FY00:5341,000
Projected Total: 52,304,800
4. Chronic Beryllium Disease Among Beryllium-Exposed Workers
Awardee: Michigan State University (Kenneth Rosenman, M.D.)
Award Period: 9/30/95 - 9/29/00
Summary:
This cross-sectional study of 1000 workers at 2 plants
will examine the natural history of chronic beryllium
disease (CBD) and evaluate the utility of the
lymphocyte transformation test (LTT) in detecting
beryllium sensitization and predicting CBD
development. The effectiveness of medical treatment of
sensitized workers and of control measures in
preventing overt CBD will also be evaluated.
Characterizes disease process; health outcome other
than cancer; morbidity study; pertinent to current
workers; applicable to surveillance
Annual Budgets: FY98: S 248,900 FY99: S 322,000 FY00: S317,000
Projected Total: Si,598,500
Significance:
5.
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Awardee:
National Jewish Center for Immunology and
Respiratory Medicine (Lee Newman, M.D.)
Award Period:
9/30/95 - 9/29/00
Summary: This investigation will determine the natural history of
beryllium sensitization and subclinical CBD and
identify specific beryllium compounds and processes
associated with CBD. Exposure-response relationships
for both sensitization and CBD will also be determined.
Exposure assessment is underway at an Alabama plant
where take-home toxicants are being assessed for 60
employees.
Significance: Characterizes disease process; evaluation of
intervention methods; health outcome other than
cancer; morbidity study; pertinent to current workers;
applicable to surveillance
Annual Budgets: FY98: S 248,900 FY99: $322,000 FY00: S 317,000
Projected Total: $1,598,500
lib. EXTRAMURAL RESEARCH (GRANTS)
1. Mortality Among Female Nuclear Weapons Workers
Grantee: State University of New York (Gregg Wilkinson, Ph.D.)
Award Period: 9/30/94 - 9/29/99
Summary: Although 80,000 female workers have been employed at
DOE facilities over the years, small numbers of female
workers at any one facility has limited previous health
studies. Female workers from 12 DOE plants will be
combined in this cohort mortality study. Risk estimates
will be developed for exposure to ionizing radiation or to
chemical hazards. As of July 1, 1997, the Principal
Investigator and grant was relocated to the State
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Significance: Only study of females at DOE sites; assessment of
potential confounders
Annual Budgets: FY97: $135,000 FY98: $0 FY99: $60,000
Projected Total: $818,000
2. Glycophorin A Biodosimetry in 1-131 Treated Patients
Grantee: University of Pittsburgh (William Bigbee, Ph.D.)
Award Period: 9/30/94 - 9/29/99
Summary:
This research will evaluate the glycophorin A (GPAy-
based human in vivo somatic cell mutation assay as a
retrospective biodosimeter for use in epidemiologic
studies. The response of the assay as a biodosimeter of
radiation exposure will be validated in a longitudinal
study of patients receiving I31I therapy for thyroid
disease.
Significance:
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NIOSH Energy-Related Health Research Program:
Ongoing Research
Page 21
Annual Budgets: FY98: $0 FY99: $0 FY00: $0
Projected Total: $230,000
3. Measurement Error Methods for Underground Miner Studies
Grantee: University of Southern California (Dan Stram, Ph.D.)
Award Period: 9/30/95 - 9/29/99
Summary: This study will develop methods to deal with radiation
exposure measurement errors when exposures are
extended over time and apply them in a reanalysis of
exposure-time-response (including dose rate effects) in
lung cancer mortality for uranium miner cohorts in the
Colorado Plateau and New Mexico.
Significance: Developing statistical methods for addressing
measurement uncertainty; may be useful to Department
of Justice in disposition of uranium miner compensation
issues
Annual Budgets: FY97: 5189,000 FY98: SO FY99: SO
Projected Total: S536,000
4. Lung Fibrosis in Plutonium Workers
Grantee: National Jewish Center for Immunology and Respiratory
Medicine (Lee Newman, M.D.)
Award Period: 9/30/95 - 9/29/99
Summary: Plutonium-induced lung fibrosis has been observed in
multiple species, but non-malignant respiratory disease
has not been studied in an exposed worker population.
This project will determine if workers are at increased
risk for developing radiographic abnormalities consistent
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NIOSH Energy-Related Health Research Program:
Ongoing Research
Page 22
exposures and lung fibrosis will be examined in lung
biopsies of RFP workers.
Morbidity study, non-cancer health outcome; uses data
from RFP mortality study; other than radiation exposure
Significance:
Annual Budgets: FY98: SI58,000 FY99: $0
Projected Total: $466,000
5. Study of Heat Stress and Performance in Carpenters at DOE Sites
Grantee:
Award Period:
Summary:
Significance:
United Brotherhood of Carpenters Health and Safety
Fund (Kenneth Rosenman, M.D.)
9/30/95 - 9/29/99
This study will determine if heat stress from the use of
protective clothing affects performance of carpenters and
other construction workers in remediation and hazardous
waste work at Hanford and Oak Ridge. Physiologic
measures of heat stress and neurobehavioral performance
will be assessed under actual working conditions.
Non-radiation study; non-mortality study; applicable to
current workers; preponderance of work at DOE sites;
applicable to surveillance- -
Annual Budgets: FY98: $0 FY99: SO FY00: SO
Projected Total: S278,300
6. Ionizing Radiation and Mortality Among Hanford Workers
Grantee: University of North Carolina (Steven Wing, Ph.D.)
Award Period: 9/30/96 - 9/29/99
Summary: This study will reanalyze cancer and non-cancer
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NIOSH Energy-Related Health Research Program:
Ongoing Research
Page 23
Significance:
level external radiation exposure. New methods will be
used to estimate doses previously assumed to be zero
and to consider internal dose in analyses of health risks.
New analytic methods will be used to considering time-
related exposure effects such as age at exposure.
Update of important previous cohort study (increased
time of observation). Application of new methodologies
for epidemiologic analyses.
Annual Budgets: FY98: 5195,000
Projected Total: $587,000
FY99: $0 FY00: $0
7. Acute Radiation Syndrome in Russian Nuclear Workers
Grantee: University of Pittsburgh (Neil Wald, M.D.)
Award Period: 12/1/96 - 12/04/98
Summary:
Significance:
The long-term objective is to facilitate the acquisition of
clinical diagnostic and prognostic information needed to
improve the early recognition of the Acute Radiation
Syndrome (ARS) by non-expert medical and
paramedical personnel in hospital and field conditions.
The study will utilize data from 59 ARS cases that
occurred from 1948 to-the present among workers at the
Mayak nuclear facilities in Russia.
International collaboration; non-cancer study
Annual Budgets: FY97: 5172,000
FY98: 587,000 FY99: SO
Projected Total:
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NIOSH Energy-Related Health Research Program:
Proposed Research
Page 1
Proposed Research
As stated previously, the NIOSH energy-related health research agenda addresses objectives that
have been identified with input from a variety of sources. These objectives are listed in the
section titled "Research Agenda." Each of the proposed activities outlined below addresses one
or more of these research objectives. In addition, each has been presented to and approved by the
DHHS Advisory Committee. However, these research objectives should not be considered a
final and/or comprehensive list addressing all research opportunities or knowledge gaps. In the
near future, it is our intention to work with the Advisory Committee to refine and prioritize the
research objectives that have served as the cornerstone for the NIOSH research agenda. Future
research activities will reflect those discussions.
Funding estimates for these activities are not presented here. However, they have been factored
into the Fiscal Year 2000 funding request.
1. Exposure Assessment of Hazardous Waste, Decontamination and Decommission,
and Clean-up Workers (Phases II and III)
Summary: Phase II would require that site visits be done; additional site information
gathered; and consideration of feasibility be completed in conjunction with
hypothesis generation from data obtained during Phase I. A prioritization
of research efforts addressing hazards and exposures encountered by these
workers will also be performed. Phase II will conclude with the
identification of several research hypotheses for study in Phase III.
Significance: Pertinent to current and future workers; applicable to surveillance; many
sites are undergoing clean-up and remediation activities.
2. Update of Cohort Mortality Study of Mound Workers, Miamisburg, Ohio
Summary: This facility has engaged in operations involving exposures to polonium-
210, plutonium-238, and tritium. A mortality study through 1979 showed
elevated lung cancer mortality in workers employed from 1943-1959 and a
significant dose-response relationship between plutonium-238 exposure
and lymphopoietic/hematopoietic cancers and leukemia. An update would
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NIOSH Energy-Related Health Research Program:
Proposed Research
Page 2
Significance: Improved assessment of exposure to polonium-210 (using more current
models)
3. Medical/OfF-Site Radiation Exposures
Summary: The effect of medical and off-site exposures to ionizing radiation on
epidemiologic studies of workers has never been evaluated. Risk
estimates from studies that do not consider the possible effects of these
exposures could be biased. The study will determine the feasibility of
using medical and off-site records for workers and, if feasible, doses
would be recalculated using information from these additional sources of
radiation.
Significance: Improved risk estimates.
4. Case-Control Study of Brain Cancer
Summary: Several mortality studies at Los Alamos, Oak Ridge, Y-12, and Rocky
Flats have found non significant excess brain cancer. Individually these
studies lacked sufficient power to evaluate exposure response associations
due to the rarity of brain cancer and the relatively small size of the cohorts.
Preliminary feasibility analysis indicates that there are sufficient number
of brain cancer cases across the DOE complex to support a pooled case
control study to investigate the association of the disease with ionizing
radiation exposures.
Significance: A better understanding of whether radiation exposure is associated with
brain cancer.
5. Case-Control Study of Thyroid Cancer Incidence
Summary: An incidence study of communities surrounding the Nevada nuclear
weapons testing Site (Kerber 1993) observed a significant positive dose
response trend for thyroid cancer. Yet the risk of thyroid cancer incidence
in DOE workers potentially exposed to radioiodine have not been well
characterized. Further assessment of thyroid cancer incidence among
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NIOSHEnergy-Related Health Research Program:
Proposed Research
Page 3
scientific interest.
Significance: Thyroid cancer is among the most easily screened and treated cancers;
identification of workers at increased risk would have implications for
intervention with current and former workers.
6. Case-Control Study of Bone Cancer
Summary: Uranium, the most common alpha-emitting radionuclide that DOE
workers experienced as an internal exposure, has well known tumorigenic
potential. Worker cohort studies have not demonstrated significant
elevated risk for bone cancer, due primarily to low statistical power to
detect an excess. This project would conduct a pooled case-control study
of bone cancer deaths across DOE sites where uranium was present in the
work environment. This study would provide the most sensitive
evaluation of excess bone cancer in nuclear workers possible.
Significance: Implications for alpha emitters absorbed internally.
7. Case-Control Study of Breast Cancer
Summary: Although breast tissue is radiosensitive, DOE studies have not evaluated
female workers due to their small numbers at any one site. There are 3
known cases of female breast cancer at Zia, 4 at Rocketdyne, 45 at
Hanford and 263 at Oak Ridge facilities-,-but other cohorts have not
reported on the number of cases. By combining cohorts, sufficient
numbers of breast cancer cases may be available to provide the statistical
power needed to detect an excess. It is believed that there would be
sufficient numbers of workers with a non-zero radiation dose to support a
meaningful epidemiologic study.
Significance: As the number of women in the workforce increases, it becomes possible
to detect excess risks. Early detection programs for breast cancer have life
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NIOSH Energy-Related Health Research Program:
Proposed Research
Page 4
8. JEM Data Sensitivity Analysis
Summary: A sensitivity analysis will be performed to determine "how much data is
enough" to construct a reasonably accurate job exposure matrix. This
study will: (1) identify a set of health physics monitoring data with known
work histories and tasks; (2) use programming to selectively remove
various portions of the data (e.g., collapse job titles and reduce sample
sizes within jobs) according to preset criteria; (3) determine indicators of
instability or unreliability, using various modeling techniques; and (4)
determine the level of uncertainty of the estimates at each level of data
completeness.
Significance:
Exposure assessment methods research; estimates of uncertainty in
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NIOSH Energy-Related Health Research Program:
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Page 1
Medical Surveillance Grants/Activities Program
OVERVIEW
NIOSH medical surveillance of former Department of Energy(DOE) workers is divided into two
separate areas under different enabling authorizations. In accordance with these authorizations,
NIOSH administers research grant activities and also evaluates research progress for ongoing
DOE cooperative agreements in medical surveillance. Former workers under the Memorandum
of Understanding between DOE and the Department of Health and Human Services (DHHS),
NIOSH administers five DOE-funded research grants.
Under the requirements of the Defense Authorization Act of 1993, DOE must work with DHHS,
the Centers for Disease Control and Prevention (CDC) and the National Institute for
Occupational Safety and Health (NIOSH) "regarding determinations of significant health risk
resulting from DOE work-related exposures." Under the Memorandum of Understanding'
between DOE and DHHS, DOE has therefore asked that NIOSH independently conduct peer
reviews of six medical surveillance needs assessment projects and make recommendations to
DOE regarding continuation of these projects. Similar requests are likely to be received for four
new medical surveillance cooperative agreements recently initiated by DOE.
RESEARCH GRANTS ADMINISTRATION
1. WORK HISTORIES EVALUATING NEW PARTICIPATORY METHODS
(Grant R01 CC512026-01)
Grantee: University of Cincinnati
Eula Bingham, Ph.D.
Grants Office Advisor: David Pedersen, Ph.D
Award Period: 9/30/95 - 9/29/99
Summary: Workers in the construction trades are exposed to a wide variety of chemical
and radiological agents at DOE sites. Creation of an exposure his tors' for these workers is
difficult due to the difficulty in recalling their complex exposure patterns across a large
number of short-term workplace assignments. In order to provide an improved basis for
the characterization of worker occupational exposures over time, this project is aimed at
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NIOSH Energy-Related Health Research Program:
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Page 2
recall. The technique found to be the most efficient and effective in identifying workers
at higher risk will then be tested at a different DOE site with a new cohort, to validate
guidelines and formats for the maintenance of personal work histories.
Significance: Validated improvements in assembling retrospective occupational
exposure histories have general application in increasing the validity of studies of the
associations between exposure histories and health risk(s). Specific benefits from this
improvement include increased capability to allocate medical surveillance resources more
effectively, thus reducing unnecessary and duplicative effort.
2. COMPREHENSIVE OCCUPATIONAL HEALTH SURVEILLANCE
(Grant 1R01 CC12031)
Grantee: University of Washington
Scott Barnhart, Ph.D.
Grants Office Advisor: David Pedersen, Ph.D.
Award Period: 9/30/95 - 9/29/99
Summary: This project is concerned with the design and implementation of a model
occupational safety and health surveillance system. The goal of this system is to gather
appropriate occupational medicine and industrial hygiene data to provide data for the
systematic identification of hazardous exposures and adverse health outcomes.
Significance: Readily available computerized information on workplace exposures and
health status organized by specific tasks through a Employee Job Task Analysis (EJTA)
provides the information for accurate risk assessmeritsleading to reduction of hazardous
exposures. This level of documentation also supports objective evaluation of
occupational health program intervention effectiveness, and contributes to worker
(stakeholder)involvement in prevention efforts.
3. HAZARD SURVEILLANCE IN THE DEFENSE NUCLEAR INDUSTRY
(Grant 1 R01 CC912034)
Grantee: University of California at Los Aangeles
John Froines, Ph.D.
Grants Office Advisor: David Pedersen, Ph.D.
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NIOSH Energy-Related Health Research Program:
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Page 3
Summary: This project is intended to develop an integrated approach to statistical
models for exposure assessment, especially characterization of occupational exposure to
complex mixed exposures to chemical and biomechanical problems. Based on measured
task-specific exposure data, the project is dedicated to the identification of appropriate
statistical tools to model single- and mixed-agent exposures and resulting internal doses.
Significance: This research has application in complex exposure situations through
provision of an additional avenue for evaluating the relationships between exposure
concentration and worker dose. And, the modeling capabilities of the developed system
will provide a risk-based estimation of adverse health effect incidence on the basis of
assessed environmental exposures to guide health interventions, including medical
surveillance.
4. SENTINEL EXPOSURE EVENT SURVEILLANCE/EVALUATION
AT DOE SITES
(Grant 1 R01 CCR8120441)
Grantee: University of Colorado
James Ruttenber, M.D.
Grants Office Advisor: David Pedersen, Ph.D.
Award Period: 9/30/95 - 9/29/99
Summary: This project is intended to develop a generic hazard surveillance and
evaluation system for exposures to chemical and radiation exposures. Based on a job/task
evaluation and analysis, the Sentinel Exposure Event (SEE) system will include exposure
level measurements, worker-specific task definitionsrand observation data (controls,
conditions of exposure, and defined health and safety policies). This input will be
incorporated into a system for evaluating exposures, enhancing worker communications,
and identifying necessary interventions through internally generated reports.
Significance: The practice of using job/task definition as the fundamental unit of
observation in a comprehensive exposure evaluation and reporting system provides
generic capabilities for the identification and direction of occupational health
interventions and enhanced worker communications. The potential for indicating and
guiding improvements in occupational health program initiatives may have direct impact
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NIOSH Energy-Related Health Research Program:
NJOSHEnergy-Related Medical Surveillance Grants/Activities Program
Page 4
EVALUATION OF MEDICAL SURVEILLANCE
NEEDS ASSESSMENT REPORTS
OVERVIEW
DOE is funding a number of cooperative agreements at various DOE sites to develop a program
of medical evaluation for former DOE workers at significant risk for health problems due to
exposures to hazardous or radioactive substances. These studies were divided into two phases.
The first phase is a comprehensive needs assessment which involves identification of the worker
cohort at risk and an evaluation of their occupational'exposures and potential for adverse health
effects. The second phase, based upon approval of first phase activity results, focuses on the
development of necessary medical screening protocols for "groups of workers at significant risk
for health effects."
DOE determines the need for Phase II activities based on review and evaluation of the reports of
Phase I activity, and supports Phase II efforts only for those studies which adequately
demonstrate the need for continued study. This finding is based in large part on the NIOSH
review. In order to comply with the formal DOE request that NIOSH (Division of Surveillance,
Hazard Evaluations and Field Studies) provide Phase I reviews and evaluations, a formal panel
review process was established.
This process involves the selection of multi disciplinary panels for each cooperative agreement
report. These panel consist of representative professionals from such disciplines as occupational
medicine, industrial hygiene, health physics, epidemiology, and records management, along with
other expertise as required. The panel expertise mix is specific to each research effort, and
members are selected by Mr. Larry Elliott and Dr. David Pedersen. Panel members operate
independently in their evaluation of the cooperative agreement reports in accordance with
standardized formal directions assembled by Dr. David Pedersen, acting as review panel
coordinator. The coordinator also collates the individual panel member evaluations into a
summary report, which is sent to DOE. The status of these DOE cooperative agreements may be
ascertained by contacting DOE-EH61, Dr. George Gebus or Dr. Michael Montopoli at 301-903-
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NIOSH Energy-Related Health Research Program:
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Page 5
Department of Energy (COOPERATIVE AGREEMENTS REVIEWED)
1. Medical Monitoring Program for Former Workers at Rocky Flats Environmental
Technology Site - RFETS
Principal Investigator: James Ruttenber, M.D.
University of Colorado
Target Population: Former Rocky Flats Production Workers (Excluding Cleanup
Workers) who were involved with weapons production between
1951 and 1989. The starting point for the target population is
14,430 former workers.
2. Surveillance of Former Construction Workers at Oak Ridge Reservation
Principal Investigator: Eula Bingham, Ph. D
University of Cincinnati
Target Population: Former construction workers involved with selected buildings in
the Oak Ridge Gaseous Diffusion Plant (K-25), Y-12 Plant and
Oak Ridge National Laboratory (X-10). The needs assessment
document did not specify the size of the target population The
initial starting point was defined as 1943, the start of construction
at Oak Ridge.
3. Medical Surveillance of Former Hanford Workers (Non-Construction Trade
Workers) " ""
Principal Investigator: Scott Bamhart, M.D., M. P. H.
University of Washington
Target Population: The investigators have limited the notification/medical screening
program to former (1943-1997) non-construction trade workers
who were potentially exposed to asbestos (-29,002), noise
(-36,698), and beryllium (-14,870).
4. Medical Surveillance for Former Department of Energy Workers at the Nevada
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NIOSH Energy-Related Health Research Program: Page 6
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Principal Investigator: Lewis Pepper, Ph. D.
(Boston University)
Target Population: Former NTS construction trade workers (underground and
excavation construction workers and reentry crews), who worked
between 1956 and 1991. Approximately 16,400 workers were
represented by six construction trade unions for this period of time.
The number of these workers still alive is not known, but for the
purposes of the Phase I Document, a cohort size of 15,000 is used.
5. Former Worker Medical Surveillance Program at Department of Energy Gaseous
Diffusion Plants
Principal Investigator: Robert Wages
Oil, Chemical and Atomic Workers International Union
Target Population: Former DOE production workers at the gaseous diffusion plants in
Portsmouth, Ohio, Paducah, Kentucky, and Oak Ridge (K-25),
Tennessee. The investigators limited the notification and medical
screening programs to (1) those workers with potential risk for
bladder cancer at K-25 (estimated to be 500-600 workers who
might be located and be eligible) and (2) those workers with
potential risk for a variety of lung diseases, including chronic
obstructive lung disease, pneumoconioses and lung cancer. (The
first priority group of workers at risk of lung disease was estimated
to be 2,350-3,530 workers at K-25,300-400 workers at Portsmouth
and 200-300 workers at Paducah; a second priority would include
5,000-7,000 workers at K-25, 3,000-5,000 workers at Portsmouth
and about 2,000 workers at Paducah.).
6. Medical Surveillance of Former Hanford Workers (Non-Construction Trade
Workers)
Principal Investigator: Scott Schneider
The Center to Protect Workers' Rights
Target Population: Currently, the investigators have limited the notification/medical
screening program to former (1943-1997) non-construction trade
workers who were potentially exposed to asbestos (-10,075). noise
I \ <
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NIOSH Energy-Related Health Research Program:
NIOSH Energy-Related Medical Surveillance Grants/Activities Program
Page 7
(~12,758) and beryllium (-4,638). The investigators are currently
evaluating existing records to determine if workers potentially
exposed to such hazards as ionizing radiation, solvents, heavy
metals, welding fumes, "other" respiratory irritants, and metal
working fluids should be included in a medical surveillance
program.
7. Savannah River Site—Former Production Workers Medical Surveillance Program
Principal Investigator: David Hoel, Ph. D.
Medical University of South Carolina
Target Population: Former production workers at the Savannah River Site (SRS) who
worked from inception in 1950 to the present. It is estimated that
this includes 25,580 production workers ( at this point, there is no
estimate of the number of these workers that are still alive). The
hazards that justify medical surveillance include: asbestos (from
1,770 -4,000 workers), beryllium (from 0-100 workers), dioxane
(from 8-822 workers), hydrazine (from 114-3.054 workers),
hydrogen sulfide (from 1.976-4,000 workers), external ionizing
radiation (from 340-574 workers), internal radiation (
approximately 150 workers), noise (from 8,221-10,000 workers),
perchloroethylene (from 90-4,323 workers), polychlorinated
biphenyls (approximately 13 workers), transuranium (no estimate
given) and trichloroethylene (approximately 822 workers).
8. Savannah River Building Trades Medical Screenmg"Program
Principal Investigator: Scott Schneider
The Center to Protect Workers' Rights
Target Population: Former and Current Building Trades Workers (building and
construction workers) at the Savannah River Site (SRS) who
worked from inception in 1950 to the present. It is estimated that
this includes 62,000 workers of whom 37,250 are alive. Of these
individuals, the investigators estimate they will interview 17,200
workers and will conduct a medical assessment on 7,750 of the
17.200 based on either available medical records or by conducting
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NIOSH Energy-Related Health Research Program:
NIOSHEnergy-Related Medical Surveillance Grants/Activities Program
Page 8
include: asbestos, cadmium, chromium, heavy metals, ionizing
radiation, lead, mercury, silica, solvents, noise, and welding fumes.
Beryllium and tritium also were listed, but more tentatively.
9. Medical Surveillance for Former Idaho Falls, Idaho Workers
Principal Investigator: Robert Wages
Oil, Chemical and Atomic Workers International Union
Target Population: Submission of Phase I. Report not complete
10. Medical Surveillance Program for Former Los Alamos National Laboratory
Workers
Principal Investigator: Brian Schwartz, M.D., M.S. and Patrick Breysse, Ph. D.
The Johns Hopkins University
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&
V
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Figure 2
Occupational Energy Research Program Study Sites
October 1998
Acronyms
INEEL:
RIOTS
LANL
I'antex
Idaho National Engineering and
Environmental Laboratory
LANL: Los Alamos National Laboratory
NTS: Nevada Test Site
PORTS: Portsmouth Gaseous Diffusion Plant
I'NS: Portsmouth Naval Shipyard (Non-DOE site)
RFETS: Rocky Flats Environmental Technology Site
iMalllnckrocl
Moukd^.
Fert^IcT-rbhTS
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~3
&
M
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NIOSH Energy-Related Health Research Program:
Research Partners
Page 1
Research Partners
The Health-Related Energy Research Branch has established numerous partnerships which have
proven productive in the conduct of its intramural and extramural research program. These
partnerships are with labor, academia, contractors, international organizations, and state and
other governmental agencies. The research may be conducted within NIOSH and CDC
(intramurally) or extramurally through grants, contracts, and cooperative agreements with the
partners listed below.
Academia/Other:
Battelle Pacific Northwest Labs.
Battelle Memorial Institute
Boston University School of Public Health
Coalition of Black Trade Unionists
Computer Science Corporation
HGO Technology
International Agency for Research on Cancer
International Brotherhood of Electrical Workers
Michigan State University
National Jewish Center for Immunology
and Respiratory Medicine
Oak Ridge Associated Universities
Oil, Chemical and Atomic Workers
Survey Research Associates, Inc.
Tri-S
United Brotherhood of Carpenters
University of California at Los Angeles
University of Cincinnati
University of Colorado
University of Pittsburgh
University of Southern California
University of Texas Medical Branch
University of Washington
Westat Corporation
National Institute for Occupational Safety and Health (NIOSH)
Division of Surveillance, Hazard Evaluations^and Field Studies
Hazard Evaluations and Technical Assistance Branch
Industrywide Studies Branch
Support Services Branch
Surveillance Branch
Division of Biomedical and Behavioral Sciences
Division of Respiratory Disease Studies
Physical Science and Engineering
Centers for Disease Control and Prevention (CDC)
National Center for Environmental Health (NCEH)
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NIOSH Energy-Related Health Research Program:
Research Partners
Page 2
Department of Health and Human Services
Agency for Toxic Substances and Disease Registry (ATSDR)
Office for the Protection from Research Risks (OPRR)
National Cancer Institute (NCI)
National Institute of Environmental Health Sciences (NEEHS)
Other Government
Department of Energy
Office of Environment, Safety and Health
Office of Environmental Management
Office of Energy Efficiency and Renewable Energy
Environmental Protection Agency
State Health Departments (Colorado, Idaho, New Mexico, Ohio,
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A'IOSH Energy-Related Health Research Program:
Table II - Points of Contact by Study
Page 1
Table II
Points of Contact by Study
NIOSH Occupational Energy Research Program
October 1998
Study Name
NIOSH Project Officer
> (PO)
NIOSH PO
? Phone/Fax/
E-Mail
External Principal .
Investigator (PI) '.L)p
External PI .
M'Phone/Fax/E-Mail ¦
¦ [;V
INTRAMURAL STUDIES
Portsmouth Gaseous Diffusion Plant
Nested Case-Control Studies (PORTS)
Robert Rinsky, Ph.D.
513-841-4131
513-841-4470
rarl@cdc.gov
N/A
N/A
Colioit Mortality Study of Idaho National
Engineering and Environmental
Laboratory (INEEL)
David Uttcrback, Ph.D.
513-841-4492
513-841-4470 (fax)
dfuO@cdc.gov
N/A
N/A
Cohort Mortality Study of Portsmouth
Naval Shipyard (PNS)
Robert Rinsky, Ph.D.
513-841-4131
513-841-4470 (fax)
rarl@cdc.gov
N/A
N/A
I.cukcmia Case-Control Study
Thurman Wenzl, Sc.D.
513-841-4490
513-841-4470 (fax)
tywl@cdc.gov
N/A
N/A
Multiple Myciomalasc Casc-ContTol
Study at the Oak Ridge Gascons Diffusion
Plant (K-25)
M. Kathryn Brown, Ph.D.
513-841-4468
513-841-4470 (fax)
kgb4@cdc.gotf
N/A
N/A
Exposure Assessment of Hazardous
Waste, Decontamination and
Decommissioning and Clean-up Workers
(Phase I)
Steven Ahrcnholz, Ph.D.
513.841.4471
513-841-4470 (fax)
shal@cdc.gov
N/A
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NIOSH Energy-Related Health Research Program:
Table II - Points of Contact by Study
Page 2
Study Name
NIOSH Project Officer :
(po) : ;
• NIOSH PO
.X Phone/Fax/
'IE-Mail;
¦ External Principal
1 Investigator (PI) -
.; External PI ¦
Cohort Mortality Study of DOE Chemical
Laboratory Workers
Cindy Robinson, Ph.D.
513-841-4217
513-841-4470(fax)
cfr2@cde.gov
N/A
N/A
Cohort Mortality Study of Pantex Plant,
Amarilto, Texas
Barbara Grajewski, Ph.D.
513-841-4429
513-841-4470 (fax)
bag2@cdc.gov
N/A
N/A
Lung Cancer Case-Control Study
Barbara Grajewski, Ph.D.
513-841-4429
513-841-4470(fax)
bag2@cdc.gov
N/A
N/A
Construction Mortality Study
Cindy Robinson, Ph.D.
513-841-4217
513-841-4470(fax)
cfr2@cdc.gov
N/A
N/A
Registry for Health and Work Histories
Information
j^indy Robinson, Ph.D.
513-841-4217
513-841-4470
cfr2@cdc.gov
N/A
N/A
Bladder Cancer Incidence Study at Oak
Ridge K-25 Plant
Sharon Silver, M.A.
513-841-4313
513-841-4470
zre4@cdc.gov
N/A
N/A
Cohoit Mortality Study of Fcrnald
Environmental Management Plant
Rita Espinoza, M.P.H.
513-841-4375
513-841-4470 (fax)
ree6@cdc.gov
N/A
N/A
Mortality Study of the Zia Cohort
Travis Kubalc, M.S.W.
513-841-4461.
513-841-4470
tek2@cdc.gov
N/A
N/A
Cancer Incidence and Sentinel Event
Registries
Rita Espinoza, M.P.H.
513-841-4561
513-841-4470
ree6@cdc.gov
N/A
-------
NIOSIf Energy-Related Health Research Program:
Tabic II - Points of Contact by Study
Page 3
Study Name
NIOSH Project Officer
(PO)
NlOSH PO
tf'^pJwne/JKax/ V
;.... .
. External Principal
;.'^Investigator:(PI) }(¦
;*¦ |" >»'' ' ' ''< "T ' ' ' • ' 1 ' *4
i^^External PI'' ^P
Civilian Nuclear Power Workers Mortality
Study
Robert Rinsky, Ph.D.
513-841-4131
513-841-4470
rarl@cdc.gov
N/A
N/A
Retrospective Exposure Assessment for
Workers at the Fcrnald Plant
Mark Methner, Ph.D.
513-841-4468
513-841-4470
mmm5@cdc.gov
N/A
N/A
Uranium Miners Data Retrieval and
Coding
Mark Methner, Ph.D.
513-841-4468
513-841-4470
mmm5@cdc.gov
N/A
N/A
Exposure Assessment of Radiologic
Technologists for Epidemiology Studies
David Uttcrback, Ph.D.
i
513-841-4492
513-841-4470
dfuO@cdc.gov
N/A
N/A
Assessment of Electric and Magnetic Field
Exposures of Transportation Workers
"jliurman Wenzl, Sc.D.
513-841-4490
513-841-4470
tywl@cdc.gov
N/A
N/A
Neutron Exposure Assessment in
Epidemiology Studies of DOE Cohorts
Tim Taulbce, B.S.
513-841-4468
513-841-4470
shal@cdc.gov
N/A
N/A
Documentation ofHistorical Dosimetry
Practices at DOE Sites
Steven AhrcnJioIz, Ph.D.
513-841-4471
513-841-4470
dfu0@cdc.gov
N/A
N/A
Workshop on the Effects of Radiation and
Age of Exposure
Robert Rinsky, Ph.D.
513-841-4131.
513-841-4470
rarl@cdc.gov
N/A
N/A
Community Involvement and Worker
Outreach
Larry Elliott
513-841-4465
513-841-4470 (fax)
Ijel@cdc.gov
N/A
-------
NIOSII Energy-Related Health Research Program:
Table II - Points of Contact by Study
Page 4
Study Name
NIOSH Project Officer i
(PO) !
..NIOSUPO
-Phbne/Fa*/ •;
ii'.'
•. External Principal V
.'/'.-Investigator (PI)
k^Monc/Fax/E-Mail. -
| •' ¦ ~ '¦Svv/.r
EXTRAMURAL STUDIES (COOPERATIVE AGREEMENTS)
Cancer Incidence/Mortality Study of
Rocky Flats Plant
Dennis Zaebst, M.S., C.I.H.
513-841-4459
513-841-4470 (fax)
ddzl@cdc.gov
Norma Morin, Ph.D.
Colorado Department of
Public Health
303-692-2636
303-782-0188 (fax)
normie.morin@state.co.us
International Collaborative Study of
Nuclear Industry Workers
Robert Rinsky, Ph.D.
513-841-4131
513-841-4470 (fax)
rarl@cdc.gov
Elisabeth Cardis, Ph.D.
IARC
011-334-7273-8508
011-334-7273-8575 (fax)
cardis@iarc.fr
Prevention of Stress and Health
Consequences of Downsizing and
Reorganization
Larry Murphy, Ph.D.
513-533-8171
513-533-8596 (fax)
lrm2@cdc.gov
Lewis Pepper, M.D.
Boston University
617-638-4620
617-638-4857 (fax)
lpepper@bu.edu
Chronic Beryllium Disease Among
Beryllium-Exposed Workers
I^aul Henneberger, Sc.D.
!
304-285-5756
304-285-5861 (fax)
pkhO@cdc.gov
Ken Rosenman, M.D.
Michigan State Univ.
517-353-1846
517-432-3606 (fax)
21770kdr@msu.edu
Beryllium Disease Natural History and
Exposure Response
Paul Henneberger, Sc.D.
304-285-5756
304-285-5861 (fax)
pkhO@cdc.gov
Lee Newman, M.D.
Natl. Jewish Center for
Immun. & Resp. Med.
303-398-1725
303-398-1851 (fax)
newmanl@njc.org
EXTRAMURAL STUDIES (GRANTS)
Mortality Among Female Nuclear
Weapons Workers
David Utterback, Ph.D.
513-841-4492
513-841-4470 (fax)
dfuO@cdc.gov
Gregg Wilkinson, Ph.D.
University of Buffalo
716-821-2975x641
716-829-2979 (fax)
gwilkins@acsu.buffalo.edu
Glycophorin A Biodosimctry in 1-131
Treated Patients
Thomas Rcid, Ph.D.
513-533-8294.
513-533-8510
tar9@cdc.gov
William Bigbee, Ph.D.
Univ. Pittsburgh
412-967-6534
412-624-1020 (fax)
w 1 bigbee+@pitt.edu
Measurement Error Methods for
Underground Miner Studies
Thurman Wcnzl, Sc.D.
513-841-4490
513-841-4470 (fax)
tywl@cdc.gov
Dan Stram, Ph.D.
Univ. Southern Calif.
213-342-1817
213-342-2349 (fax)
-------
NIOSII Energy-Related Health Research Program:
Table II - Points of Contact by Study
Page 5
Study Name
NIOSII Project Officer
(PO)
NIOSH PO
Phone/Fax/
E-Mail
External Principal -.
Investigator (PI) >
External PI. "A
¦ Phone/Fax/E-Mriil -
Lung Fibrosis in Plutonium Workers
Steven Ahrenholz, Ph.D.
513-841-4471
513-841-4470 (fax)
shal@cdc.gov
Lee Newman, M.D.
Natl. Jewish Center for
Immun. & Resp. Med.
303-398-1725
303-398-1851 (fax)
newmanl@njc.org
Study of Meat Stress and Performance in
Carpenters at DOE Sites
Jean-Louis Delard, M.D.,
Ph.D.
304-285-5987
304-285-6047 (fax)
jfb6@cdc.gov
Ken Rosenman, M.D.
Unit. Brotherhood of
Carpenters
517-353-1846
517-432-3606 (fax)
21770kdr@msu.edu
Ionizing Radiation and Mortality Among
Ilanford Workers
Robert Rinsky, Ph.D.
513-841-4131
513-841-4470 (fax)
rarl@cdc.gov
Steve Wing, Ph.D.
Univ. North Carolina
919-966-7416
919-542-4403 (fax)
swing@sphvax.sph.unc.edu
Acute Radiation Syndrome in Russian
Nuclear Workers
Larry Elliott
t
513-841-4465
513-841-4470
ljel@cdc.gov
Neil Wald, M.D.
Univ. Pittsburgh
412-624-2735
412-624-7534 (fax)
wald@vms.cis.pitt.edu
DOE SURVEILLANCE GRANTS
Woik Histories - Evaluating New
Participatory Methods
David Pedcrscn, Ph.D.
513-841-4223
513-841-4483 (fax)
dphl@cdc.gov
Eula Bingham, Ph.D.
Univ. Cincinnati
513-558-5728
513-558-5062 (fax)
Comprehensive Occupational Health
Surveillance
David Pedcrscn, Ph.D.
513-841-4223
513-841-4483 (fax)
dphl@cdc.gov
Scott Barnhart, Ph.D.
Univ. Washington
206-731-3388
206-731-8247 (fax)
sbht@u.washington.edu
Hazard Surveillance in Defense Nuclear
Industry
David Pedcrscn, Ph.D.
513-841-4223
513-841-4483 (fax)
dphl@cdc.gov
John Froines, Ph.D.
UCLA
310-206-6141
310-206-9903 (fax)
jfroincs@ucla.cdu
Scnlincl Exposure Events
Surveillance/Evaluation at DOE Sites
David Pedcrscn, Ph.D.
513-841 -4223-'
513-841-4483 (fax)
dphl@cdc.gov
James Ruttcnber, M.D.
Univ. Colorado
303-315-5627
303-315-3183 (fax)
-------
NIOSH Energy-Related Health Research Program:
Table II - Points of Contact by Study
Page 6
Study Name
NIOSH Project Officer
(PO) •:
t*. NIOSH PO
vPhone/Fax/
' ; . E-Mail . ¦
''External Principal;
'Investigator (PI)' V-
¦''TV-*.-
External PI
^fphone/F^x/E-Mall
EXTRAMURAL STUDIES (CONTRACTS)
Exposure Assessment for Mallinckrodt
Workers' Study
Timothy Taulbcc, D.S.
513-841-4468
513-841-4470 (fax)
tgt@cdc.gov
Betsy Dupree Ellis, Ph.D.
423-576-3528
423-576-3528
Technical Support Activities
Marcus Wilkins
513-841-4546
513-841-4470 (fax)
mcw5@cdc.gov
Frank Moran
Westat
Donna Cragle, Ph.D.
ORAU
301-251-4255
301-294-2040 (fax)
moranf 1 @wcstat.com
423-576-2866
423-576-9557 (fax)
-------
-------
NIOSH Energy-Related Health Research Program:
NIOSHFY98 Funding
Page 1
HERB FY98 BUDGET
ANALYTIC EPIDEMIOLOGY
MEMORANDUM OF UNDERSTANDING
October 1998
OBJECT CLASS TOTAL
11/12
Salary Benefits
2,033,107
21
Travel
179,738
22
Transport of Things
5,285
23
Rent, Utilities
95,633
24
Printing
3,108
25
Contracts Extramural
799,346
25
Contracts Intramural
623,545
26
Supplies
39,470
31
Equipment
489,862
41
Cooperative Agreements _ .
- 1,034,922
41
Grants
301,400
TOTAL
-------
Figure 3
FISCAL YEAR 1998 EXPENDITURES
NIOSII OCCUPATIONAL ENERGY RESEARCH PROGRAM
October, 1998
~ Grants
5%
Pi Cooperative Agreements
18%
W Equipment
9%
~ Supplies
1%
n Contracts, Extramural
14%
E3 Salary/Benefits
37%
liContracts, Intramural
11%
B Travel 3%
~ Postage/Cartage 0.09%
~ Rent, utilities 2%
-------
H3
-------
NIOSH Energy-Related Health Research Program:
NIOSHFY99 Funding
Page 1
HERB FY99 BUDGET
ANALYTIC EPIDEMIOLOGY
MEMORANDUM OF UNDERSTANDING
October 1998
OBJECT CLASS TOTAL
11/12
Salary Benefits
2,422,800
21
Travel
235,700
22
Transport of Things
7,500
23
Rent, Utilities
44,900
24
Printing
4,500
25
Contracts Extramural
2,291,600
25
Contracts Intramural
875,300
26
Supplies
44,900
31
Equipment
60,000
41
Cooperative Agreements -
1,345,000
41
Grants
1,836,400
TOTAL
-------
Figure 4
FISCAL YEAR 1999 BUDGET
NIOSH OCCUPATIONAL ENERGY RESEARCH PROGRAM
October, 1998
Grants
20%
Salary/Benefits
26%
Cooperative Agreements
15%
Equipment
1%
Supplies
0 5%
Travel 3%
Postage/Cartage
0.08%
Rent, utilities 0.5%
Printing 0.05%
Contracts, Intramural
10%
Contracts, Extramural
-------
i-3
6•
«-»
cr»
-------
NIOSH Energy-Related Health Research Program:
NIOSH Health-Related Energy Research Branch Staff
Page 1
NIOSH Health-Related Energy Research Branch Staff
Larry Elliott - Chief
(Open) - Assistant Branch Chief
Barbara Grajewski - Chief, Epidemiology Section
David Utterback - Chief, Exposure Assessment Section
Marcus Wilkins - Branch Administrator
Epidemiologists
Kathryn Brown
Rita Espinoza
Robert Rinsky
Cynthia Robinson
Health Communication Specialists
Travis Kubale
Bill Murray
Health Physicists
John Cardarelli
Jason Flora
Henry Spitz
Timothy Taulbee
Industrial Hygienists
Steven Ahrenholz
Krystyn Bussa
Timothy Jiggens
Mark Methner
Thurman Wenzl
Dennis Zaebst
Programmers
Pi-Hsueh Chen
Chih Yu Tseng
Kathleen Waters
Secretaries
April Jenkins
Ginger Perreault
Records Manager Open Positions
Dianne Reeder (In addition to Assistant Branch Chief)
Epidemiologist (3 positions)
Surveillance Coordinator Epi Assistant
David Pedersen Health Physicist
Statistician
Note: It is also essential to acknowledge the complement of interns, cooperative study students,
fellows, and technical and administrative support contractor employees who contribute
-------
Figure 5
Health-Related Energy Research
Branch
Organizational Chart
October 1998
Support Services Branch
Computer Specialists / Programmers
Kathleen Waters
Chlh Yu Tseng
Pi - Hsueh Chen
Statistician
Vacant
Larry Elliott
Branch Chief
Travis Ktibale
He.ilth Communications
ORISE
David Pedersen
Surveillance Coordinator
Rita Espinoza
Epidemiologist
ASPH
vacant
Assistant Chief
William Murray
Health Communications
Cynthia Robinson
Epidemioloqist
Detail
Barbara Grajewskl I
Chief, Epidemiology Section
Robert Rinsky
Epidemiologist
Vacant
Epidemiologist
Vacant
Epidemioloqist
Vacant
Epidemiologist
Kalhryn Brown
Epidemiologist
IPA
Dfanne Reeder
Records
Manager
Vacant
Epidemiologist
Assistant
COTA
Marcus Wilkins
Branch Administrator
Vacant
Administrative Assistant
COTA
April Jenkins
Ginger Perreault
Secretary
Secretary
NIOSH FTEs = 23 (H.S. 0.4 FTE not Counted)
Interagency Personnel Act (IPA) = 1
Association of Schools of Public Health (ASPH) = 1
Oak Ridge Institute for Science and Education (ORISE) = 2
Career Opportun1' "raining Agreement (COTA) = 2
David Utterback
Chief, Exposure Assessment Section
Vacant
Health Physicist
Timothy Jiggens
Industrial Hyglenist
NIOSH
Thurman Wenzl
Industrial
Hyglenist
Dennis Zaebst
Industrial Hyglenist
Henry Spitz (0.4)
Health Physicist
Timothy Taulbee
Health Physicist
Jason Flora
Health Physicist
Steven Ahrenholz
Industrial Hygienlst
Mark Me
Industi
Hyglenist
John Cat>
Head
Physic
(Long T
Trainit
Scienti
Fellov.
Krystyn P
Industi
Hygien
-------
NIOSH Energy-Related Health Research Program:
NIOSH FY98 Funding
Page 1
HERB FY98 BUDGET
ANALYTIC EPIDEMIOLOGY
MEMORANDUM OF UNDERSTANDING
October 1998
OBJECT CLASS TOTAL
11/12
Salary Benefits
2,033,107
21
Travel
179,738
22
Transport of Things
5,285
23
Rent, Utilities
95,633
24
Printing
3,108
25
Contracts Extramural
799,346
25
Contracts Intramural
623,545
26
Supplies
39,470
31
Equipment
489,862
41
Cooperative Agreements
1,034,922
41
Grants
301,400
TOTAL
-------
Figure 3
FISCAL YEAR 1998 EXPENDITURES
NIOSH OCCUPATIONAL ENERGY RESEARCH PROGRAM
October, 1998
~ Grants
5%
R Cooperate Agreements
18%
n Equipment
9%
~ Supplies
1%
n Contracts, Extramural
14%
C3 Salary/Benefits
37%
nContracts, Intramural
11%
B Travel 3%
~ Postage/Cartage 0.09%
~ Rent, utilities 2%
-------
>'
-------
NIOSH Energy-Related Health Research Program:
NIOSHFY99 Funding
Page 1
HERB FY99 BUDGET
ANALYTIC EPIDEMIOLOGY
MEMORANDUM OF UNDERSTANDING
October 1998
OBJECT CLASS TOTAL
11/12
Salaiy Benefits
2,422,800
21
Travel
235,700
22
Transport of Things
7,500
23
Rent, Utilities
44,900
24
Printing
4,500
25
Contracts Extramural
2,291,600
25
Contracts Intramural
875,300
26
Supplies
44,900
31
Equipment
60,000
41
Cooperative Agreements
_1,345,000
41
Grants
1,836,400
-------
FTgure 4
FISCAL YEAR 1999 BUDGET
NIOSH OCCUPATIONAL ENERGY RESEARCH PROGRAM
October, 1998
Grants
20%
Cooperative Agreements
15%
Equipment
1%
Supplies
0.5%
Salary/Benefits
26%
Travel 3%
Postage/Cartage
0.08%
Rent, utilities 0.5%
Printing 0.05%
Contracts, Intramural
10%
Contracts, Extramural
-------
&
M
at
-------
-------
NIOSH Energy-Related Health Research Program: • Page 1
NIOSH Health-Related Energy Research Branch Staff
NIOSH Health-Related Energy Research Branch Staff
Larry Elliott?- Chief
(Open) - AssistaiitBranch Chief:
Barbara Grajewski - Chief, Epidemiology Section
David Utterback 4 Chief, Exposure Assessment Section
Marcus Wilkins' - Branch Administrator
Epidemiologists
Kathryn Brown
Rita Espinoza
Robert Rinsky
Cynthia Robinson
Health Communication Specialists
Travis Kubale
Bill Murray
Health Physicists
John Cardarelli
Jason Flora
Henry Spitz
Timothy Taulbee
Industrial Hygienists
Steven Ahrenholz
Kiystyn Bussa
Timothy Jiggens
Mark Methner
Thurman Wenzl
Dennis Zaebst
Programmers
Pi-Hsueh Chen
ChihYu Tseng
Kathleen Waters
Secretaries
April Jenkins
Ginger Perreault
Records Manager Open Positions
Dianne Reeder (In addition to Assistant Branch Chief)
Epidemiologist (3 positions)
Surveillance Coordinator Epi Assistant
David Pedersen Health Physicist
Statistician
Note: It is also essential to acknowledge the complement of interns, cooperative study students,
fellows, and technical and administrative support contractor employees who contribute
-------
'Figure 5
Health-Related Energy Research
Branch
Organizational Chart
October 1998
Support Services Branch
Computer Specialists / Programmers
Kathleen Waters
Chlh Yu Tseng
PI - Hsueh Chen
Statistician ,.
Vacant
Larry Elliott
Branch Chief
I
Travis Kubale
Health Communications
ORISE
William Murray
Health Communications
Vacant
Assistant Chief
David Pedersen 1
Surveillance Coordinator
Mark M
Indus
Hygienis
Rita Espinoza
Epidemiologist
ASPH
Cynthia Robinson
Epidemiologist
Detail
Barbara Orajewski I
Chief, Epidemiology Section
Robert Rinsky
Epidemiologist
Vacant
Epidemiologist
Vacant
Epidemiologist
Vacant
Epidemiologist
Kathryn Brown
Epidemiologist
IPA
Dianne Reeder
Records
Manager
Vacant
Epidemiologist
Assistant
COTA
Marcus Wilkins
Branch Administrator
Vacant
Administrative Assistant
COTA
April Jenkins
Ginger Perreault
Secretary
Secretary
NIOSH FTEs = 23 (H.S. 0.4 FTE not Counted)
Interagency Personnel Act (IPA) = 1
Association of Schools of Public Health (ASPH) B 1
Oak Ridge Institute for Science and Education (ORISE) B 2
Career Opportun'' "raining Agreement (COTA) ¦ 2
David Utterback
Chief, Exposure Assessment Section
Vacant
Health Physicist
Timothy Jlggens
Industrial Hyglenist
NIOSH
Thurman Wenzl
Industrial
Hyglenist
Dennis Zaebst
Industrial Hyglenist
Henry Spitz (0.4)
Health Physicist
Timothy Taulbee
Health Physicist
Jason Flora
Health Physicist
Steven Ahrenholz
Industrial Hyglenist
Krystyn
Indus
Hygir
-------