TOXICOLOGY AND PHARMACOLOGY OF 2,4,5-T (INCLUDES DIOXINS) Bibliography Number 73-04 Prepared by Publications and Information Section Technical Services Division Office of Pesticides Programs Environmental Protection Agency 4770 Buford Highway Chamblee, Georgia 30341 September 1973 ------- Aaronson, T. A tour of Vietnam. Environment 13(2):34-43, 1971. [ABST.: HAPAB 4:71-1570, 1971.] Abelson, P.H. Pollution by organic chemicals. Science 170(3957):495, 1970. [ABST.: HAPAB 4:71-0651, 1971.] Anonymous Denoatitis and kidney damage ascribed to the weedkiller 2,4,5-T. A case report. Bull. Suppl. Mater., Clin. Toxicol. Commer. Products 111(2):10, 1959. Anonymous The strange case of the U.S. government vs. 2,4,5-T. Farm Chem. 132(12):25, 1969. [ABST.: HAPAB 3:70-0571, 1970.] Anonymous 2 4 5-T. Lancet 1(7652):885, 1970. [ABST.: HAPAB 3:70-1286, 1970.] Anonymous Another herbicide on the blacklist. Nature 226(5243):309-ll, 1970. [ABST.: HAPAB 3:70-1564, 1970.] Anonymous The debate on 2,4,5-T. Chem. Ind. No. 18:576-7, 1970. [ABST.: HAPAB 4:71-0006, 1971.] Anonymous Defoliants, deformities: What risk? Med. Wld News 11(9):15-17, 1970. [ABST.: HAPAB 3:70-0850, 1970.] ------- Anonymous Government steps up pressure on pesticides; recent joint action restricting use of 2,4,5-T herbicide portends changes in pesticide regulations and testing. Chem. Eng. News 48(18):60-1, 1970. [ABST.: HAPAB 3:70-0847, 1970.] Anonymous HEW, USDA hold firm, 2,4,5-T ruling postponed. Chem. Eng. News 48(7):11-12, 1970. [ABST.: HAPAB 3:70-0691, 1970.] Anonymous Pesticides: Still a burning issue. Med. Wld News 11(30_:5, 1970. [ABST.: HAPAB 3:70-1560, 1970.] Anonymous PSAC hiccoughs over 2,4,5-T. Nature 231(5300):210-1, 1971. [ABST.: HAPAB 4:71-1827, 1971.] Anonymous The strange case of the government vs. 2,4,5-T. II. Farm Chem. 133(3):26, 1970. [ABST.: HAPAB 4:71-0436, 1971.] Anonymous The tangled tale of 2,4,5-T. PANS 16(3):421-2, 1970. [ABST.: HAPAB 4:71-0021, 1971.] Anonymous Viet deformities: Will we ever know? Med. Wld News 12(4):4-5, 1971. [ABST.: HAPAB 4:71-0901, 1971.] Anonymous No herbicide residues in meat. Agr. Res. 20(12):6, 1972. [ABST.: HAPAB 5:Abst. #72-2373, 1972.] Anonymous Fetotoxicity. N.Z. Med. J. 75(480):304-5, 1972. [ABST.: HAPAB 6:Abst. #73-0017, 1973.] Binns, W. and Balls, L. Nonteratogenic effects of 2,4,5-trichlorophenoxyacetic acid and 2,4,5-T propylene glycol butal esters [sic] herbicides in sheep. Teratology 4(2):245, 1971. [ABST.: HAPAB 4:71-2000, 1971.] ------- Bjoerklund, N.E. and Erne, K. Phenoxy-acid-induced renal changes in the chicken. I. Ultrastructure. Acta Vet. Scand. 12(2):243-56, 1971. [ABST.: HAPAB 5:72-1292, 1972.] Bonderman, D,P. et^ al. Occupation exposed to aldrin, 2,4-D, 2,4,5-T and its relationship to esterases. Ind. Med. Surg. 40(6):23-7, 1971. [ABST.: HAPAB 5:72-0083, 1972.] Bovey, R.W. and Scifres, C.J. Residual characteristics oŁ picloram in grassland ecosystems. Texas Agr. Exp. Station Bull. 1111, July 1971, 24 pp. [ABST.: HAPAB 5:72-0285, 1972.] Brady, H.A. Light intensity and the absorption and translocation of 2,4,5-T by woody plants. Weed Sci. 17(3):320-2, 1969. [ABST.: HAPAB 3:70-0052, 1970.] Buu-Hoi, N.P. et al. Canceromimetric properties of tetrachloro-2,3,7,8 dibenso-p-dioxin ("dixon"). Compt. Rend. Ser. D. 272(10):1447-50, 1971. [ABST.: HAPAB 4:71-2465, 1971.] Buu-Hoi, et al. . Enzymatic factions as targets of the toxicity of "dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin). Naturwissenschaften 59(4):173-4, 1972. [ABST.: HAPAB 5:72-1535, 1972.] Buu-Hoi, N.P. et al. Organs as targets of "dioxin" (2,3,7,8-tetrachlorodibenzo p dioxin) intoxication. Naturwissenschaften 59(4):174-5, 1972. [ABST.: HAPAB 5:72-1536, 1972.] Cherry, J.H. Effect of auxin-herbicides on plant and animal biochemistry. HortScience 5(4):205-7, 1970. [ABST.: HAPAB 4:71-1704, 1971.] Clark, D.E. and Palmer, J.S. Residual aspects of 2,4,5-T and an ester in sheep and cattle with observations on concomitant toxicological effects. J. Agr. Fd Chcm. 19(4):761-4, 1971. [ABST.: HAPAB 4:71-2201, 1971.] ------- CIegg, D.J. Embryotoxicity of chemical contaminants of foods. Fd Cosmet. Toxicol. 9(2):195-205, 1971. [ABST*: HAPAB 4:71-2697, 1971.] Coaldrake, J.E. Preferential accumulation of radioactivity in root nodules of a legume after dosage with 2,4,5-T-14-C. Weed REs. 10(3):293-5, 1970. [ABST.: HAPAB 4:71-1862, 1971.] Collins, T.F.X. and Williams, C.H. Teratogenic studies with 2,4,5,-T and 2,4-D in the hamster. Bull. Environ. Contam. Toxicol. 6(6):559-67, 1971. [ABST.: HAPAB 5:72-0345, 1972.] Courtney, K.D. Effect of pesticide administration on the metabolism of 2,4-D and 2,4,5-T. Ind. Med. Surg. 39(7):327, 1970. [ABST.: HAPAB 3:70-1987, 1970.] Courtney, C.D. and Moore, J.A. Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 20(3):396-403, 1971. [ABST.: HAPAB 5:72-0787, 1972.] Courtney, K.D. et al. Teratogenic evaluation of 2,4,5,-T. Science 168(3933):864-6, 1970. [ABST.: HAPAB 3:70-1468, 1970.] Crosby, D.G. et al. Photodecomposition of chlorinated dibenzo-p-dioxins. Science 173(3998):748-9, 1971. [ABST.: HAPAB 4:71-2534, 1971.] Cunningham, H.M. and Williams, D.Tt Effect of tetrachlorodibenzo-p-dioxin on growth rate and the synthesis of lipids and proteins in rats. Bull. Environ. Contam. Toxicol. 7(1):45-51, 1972. [ABST.: HAPAB 5:72-1260, 1972.] Daevring, L. and Sunner, M. Cytogenic effects of 2,4,5-trichlorophenoxyacetic acid on oogenesis and early embryogenesis in DR0S0PHIL1A ^LANOGASTER. Hereditas 68(1):115-22, 1971. [ABST.: HAPAB 5:72-0130, 1972.] ------- Davis, P.W. et al. Organochlorine Insecticide, Herbicide, and Polychlorinated Biphenyl (PCB) Inhibition of NaK-ATPase in Rainbow Trout. Bull. Environ. Contain. Toxicol. 8(2):69-72, 1972. [ABST.: HAPAB 6:Abst. #73-1410, 1973.] Day, B.E. 2,4,5-T and government decisions. Proc. West. Soc. Weed Sci. No. 23:4-6, 1970. [ABST.: HAPAB 4:71-2341, 1971.] Drill, V.A. and Hiratzka, T. Toxicity of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. A.M.A. Arch. Ind. Hyg. Occup. Med. 7:61-7, 1953. Ehreriberg, L. On the Mutagenic Action of Phenoxy Acid Preparations. Newslett. Environ. Mutagen Soc. 6:27, 1972. [ABST.: HAPAB 6:Abst. #73-2214, 1973.] Emerson, J.L. e^t al. Teratogenic stuHy of 2,4,5-trichlorophenoxyacetic acid in the rat. Toxiccl. Appl. Pharmacol. 17 0?): 317, 1970. [ABST.: HAPAB 4:71-2059, 1971.] Emerson, J.L. et al. Teratogenic stuHTes of 2,4,5-trichlorophenoxyacetic acid in the rat;.- and rabbit. Fd Cosmet. Toxicol. 9(3):395-404, 1971. [ABST.: HAPAB 4:71-2698, 1971.] Epstein, S.S. A family likeness. Environment 12(6):16-25, 1970. [ABST.: HAPAB 4:71-0894, 1971.] Fang, S.C. et al_. The Metabolism and Distribution of 2,4,5-Trichlorophenoxyacetic Acid in Female Rats. Toxicol. Appl. Pharmacol. 22(2):31718, 1972. [ABST.: HAPAB 6:Abst. #73-1214, 1973.] Fang, S.C. et al. The Metabolism and Distribution of 2,4,5-Trichlorophenoxyacetic Acid in Female Rats. Toxicol.lAppl. Pharmacol. 24(4):555-63, 1973. ------- Foldesy, R.G. et al. The Effect oF~27T,5-Trichlorophenoxyacetic Acid on Two Nitrogen Fixing Bacteria Penn. Acad. Sci. Proc. 46:23^4, 1972. Foster, R.K." and McKercher, R.B. Laboratory Incubation Studies of Gilorophenoxyacetic Acids in Chernozemic Soils. Soil Biol. Biochem. 5(3):333-7, 1973. [ABST.: HAPAB 6:Abst. #73-2239, 1973] Funazaki, Z. Herbicides and deformities in Vietnam. Hokenfu Zasshi 27(1):54-5, 1971. [ABST.: HAPAB 4:71-2598;.1971.) Funazaki, Z. Teratogenicity of 2,4,5-T. Baioteku (Biotech) 3(6):464-70, 1972. [ABST.: HAPAB 5:72-1678, 1972.1 Fytizas Danielidou, R. Action of the.Herbicide 2,1,5-T (Trichlorophenoxyacetic Acid) on White Rats During the Gestation Period. .Aim. Inst. Phytopathol Benaki 10(2):148-54, 1971. (French) Galston, A.W. Herbicide usage. Science 168(3939):1607, 1970. [ABST.: HAPAB 3:70-1568, 1970.] Galston, A.W. Herbicides: No margin of safety. Science 167(3916):237, 1970. [ABST.: HAPAB 3:70-0708, 1970.] Greig, J.B. Effect of 2,3,7,8-Tetrachlorodibenzo-l,4-Dioxin on Drug Metabolism in the Rat. Biochem. Pharmacol. 21(23):3196-8, 1972. ------- Grunow, W. et al. Renal excretion of 2,4,5-T in the rat. Fd Cosmet. Toxicol. 9(5):667-70, 1971. [ABST.: HAPAB 5:72-0582, 1972.] Hall, S.M. Effects oil pregnant rats and their progeny of adequate or low protein diets containing 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) or p,p'-DDT. Fed. Proc. 31(2):726, 1972. [ABST.: HAPAB 5:72-1086, 1972.] Hall, S.M. Effects on Pregnant Rats and Their Progeny of Adequate or Low Protein Diets Containing 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) or p,p'-DDT. Diss. Abstr. Int. 33(8):3744B, 1973. [ABST.: HAPAB 6:Abst. #73-1910, 1973.] Hamilton, R.H. et al. Metabolism of phenoxyacetic acids. Metabolism of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid by bean plants. J. Agr. Fd Chem. 19(3):480-3, 1971. [ABST.: HAPAB 4:71-1718, 1971.] Hart, R.E. and Valerio, M.G. Teratogenic Effects of 2,4,5-T in Mice. Toxicol. Appl. Pharmacol. 22(2):317, 1972. [ABST.: HAPAB 6: Abst. #73-1213, 1973.] Hiltibran, R.C. The Hydrolysis of Adenosine Triphosphate by Bluegill Liver Mitochondria in the Presence of 2,4,5-T and Silvex Derivatives. Trans. 111. State Acad. Sci. 65(1/2):51-7, 1972. IABST.: HAPAB 6:Abst. #73-0959, 1973.] Hussain, S. et al. Mutagenic EFfects of TCDD on Bacterial Systems. Ambio 1(1):32-3, 1972. IABST.: HAPAB 6:Abst. #73-0094, 1973.] Jackson, W.T. Regulation of Mitosis. III. Cytological Effects of 2,4,5-Trichloro- phenoxyacetic Acid and of Dioxin Contaminants in 2,4,5-T Formulations. J. Cell Sci. 10(1)il5-25, 1972. [ABST.: HAPAB 6:Abst. #73-0918, 1973.] ------- Johnson, J.E. The public health implications of widespread use of the phenoxy herbicides and picloram. Bioscience 21(17):899-905, 1971. [ABST.: HAPAB 5:72-0092, 1972.] Johnson, J.E. Safety in the development of herbicides. Down to Earth 27(1):l-7, 1971. [ABST.: HAPAB 4:71-2405, 1971.] Kearney, P.C. et al. Persistence and Metabolism of Chlorodioxins in Soils. Environ. Sci. Technol. 6(12) -.1017-19, 1972. [ABST.: HAPAB 6:Abst. #73-0293, 1973.] Kennedy, M.V. et al. Chemical and~tliermal aspects of pesticide disposal. J. Environ. Quality l(l):63-5, 1972. [ABST.: HAPAB 5:72-0333, 1972.] Khera, K.S. and McKinley, W.P. Pre- and Postnatal Studies on 2,4,5-Trichlorophenoxyacetic Acid, 2,4-Dichlorophenoxyacetic Acid and Their Derivatives in Rats. Toxicol. Annl. Pharmacol. 22t').j :i4-28, 1972. [ABST.: HAPAB 5:Abst. #72-1995, 1972.] Khera, K.S. et al. Pre- and postnatal studies on 2,4,5-T, 2,4-D and derivatives in Wistar rats. Toxicol. Appl. Pharmacol. 19(2):369-70, 1971. [ABST.: HAPAB 4:71-2230, 1971.] Kimbrough, R.D. Toxicity of Chlorinated Hydrocarbons and Related Compounds. A Review Including Chlorinated Dibenzodioxins and Chlorinated Dibenzofurans. Arch. Environ, Health 25(2):125-31, 1972. [ABST.: HAPAB 5:Abst. #72-2165, 1972.] King, C.T.G. et al. Screening oFthe herbicides 2,4,5-T and 2,4,D [sic] for cleft palate production. Teratology 4(2):233, 1971. [ABST.: HAPAB 4:71-1997, 1971.] Kinmig, J. and Schulz, K.H. 2,4,5-T causing "occupational chloracne". Dermatologica 115:540-6, 1957. ------- Kutches, A.J. et al. Toxicological eHects of pesticides on rumen function IN VITRO. J. Agr. Fd Chem. 18(3):430-3, 1970. [ABST.: HAPAB 3:70-1730, 1970.] Leng, M.L. DDT and 2,4,5-T. Chem. Eng. News 49(12):12, 78, 1971. [ABST.: HAPAB 4:71-1339, 1971.] Leyland, A. A Case of 2,4,5-T Poisoning in the Dog. Vet. Rec. 92(6):149, 1973. Libke, K.G. et al. Effects of a Brushwood killer mixture on cattle. Mod. Vet. Pract. 52(7):37-40, 1971. [ABST.: HAPAB 5:72-0602, 1972.] Lindquist, N.G. and Ullberg, S. Distribution or the herbicides 2,4,5-T and 2,4-D in pregnant mice. Accumulation in yolk sac epithelium. Experientia 27P2):1439-41, 1Q71. [ABST.; HAPAB 3:72-0779, 1972.] Lloyd, J.W. et al. _ 2,4,5-T ancPtEe Metabolism of Testosterone-l,2-"TI by Mouse Prostate Glands. Arch. Environ. Health 26(4):217-20, 1973. [ABST.: HAPAB 6:Abst. #73-1620, 1973.] Lutz-Ostertag, Y. and Didier, R. 2,4,5-T and Embryonal Sterility. C.R. Soc. Biol. 165(12):2364-6, 1971. (French) [ABST.: HAPAB 6:Abst. #73-0119, 1973.] Maier-Bode, H. The 2,4,5-T question. Anz. Schaedlingsk. Pflanzenschutz 45(1):2-6, 1972. [ABST.: HAPAB 5:72-1150, 1972.] Martin, R.P. Effects of the herbicide 2,4,5-T on breeding bird populations. Okla. Acad. Sci. Proc. 46:235-7, 1966. ------- Mason, R.W. The Binding of Some Chlorophenoxy Acids to Bovine Serum Albumin In Vitro. Proc. Univ. Otago Med. School.50(3):61-3, 1972. [ABST.: HAPAB 6:Abst. #73-1969, 1973.] Millard, S.A. et al. Enzymes Controlling Cerebral DNA Synthesis: Response to 2,4,5-Trichlorophenoxyacetic Acid and Hexachlorophene. Biochim. Biophys. Acta 308(2):230-3, 1973. [ABST.: HAPAB 6:Abst. #73-1888, 1973.] Moore, J.A. and Courtney, K.D. Teratology studies with the trichlorophenoxyacid [sic] herbicides 2,4,5-T and silvex. ' Teratology 4(2):236, 1971. [ABST.: HAPAB 4:71-1998, 1971.] Nakajima, S. et al. Microbial Transformation of 2,4-D and Its Analogues. Chem. Pharn. Bull. 21(3):671-3, 1973. [ABST.: HAPAB 6:Abst. #73-2159, 1973.] Nelson, B. Herbicides: Order on 2,4,5-T issued at unusually high lev^el. Science 166(3908):977-9, 1969. [ABST.: HAPAB 3:70-0438, 1970.] Neubert, D. and Dillmann, I. Embryotoxic Effects in Mice Treated with 2,4,5-Trichlorophenoxyacet Acid and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Naunyn-Schmiedebergs Arch. Pharmacol. 272(3):243-64, 1972. [ABST.: HAPAB 5:Abst. #72-1745, 1972.] Nishimura, H. Teratogenic substances. Iden (Heredity) 26(5):19-22, 1972. [ABST.: HAPAB 5:72-1679, 1972.] Norback, D.H. and Allen, J.R. Chlorinated aromatic hydrocarbon induced modifications of the hepatic endoplasmic reticulum: concentric membrane arrays. Environ Health Perspect. 1:137-43, 1972. [ABST.: HAPAB 5:Abst. #72-2201, 1972.] ------- Norback, D.H. and Engblom, J.F. Chlorinated Dibenzo-p-Dioxin Distribution with Rat Tissues and Subfractions of the Liver. Fed. Proc. Fed. Amer. Soc. Exp. Biol. 32(3):236, 1973. [ABST.: HAPAB 6:Abst. #73-1684, 1973.] Patrashku, F.I. Results of Studies on the Volatility and Rate of Hydrolysis of Fenitrothion, Metathion, and Sumithion in Different Media. Khim. Sel. Khoz. 10(2):119-22, 1972. (Russian) [ABST.: HAPAB 6:Abst. #73-0045, 1973.] Pinsent, P.J.N, and Lane, J.G. A case of possible 2,4-D and 2,4,5-T poisoning in the horse. Vet. Rec. 87(8):247, 1970. [ABST.: HAPAB 4:71-0709, 1971.] Piper, W.N. et al. Metabolism of 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) in Rats. Toxicol. Appl. Pharmacol. 22(2):317, 1972. [ABST.: HAPAB 6:Abst. #73-1212, 1973.] Poland, A. and Glover, E. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: A Potent Inducer of 6-Aminolevulinic Acid Synthetase. Science 179(4072):476-7, 1973. Poland, A.P. et al. A health survey of workers in a 2,4jD and 2,4,5-T plant, with special attention to chloracne, porphyria catanea tarda and psychologic parameters. Arch. Environ. Hlth 22(3):316-27, 1971. [ABST.: HAPAB 4:71-0945, 1971.] Reid, C.P.P. and Hurtt, W. Root exudation of herbicides by woody plants: Allelopathic implications. Nature 225(5229):291, 1970. [ABST.: HAPAB 3:70-1333, 1970.] Robson, J.M. Testing drugs for teratogenicity and their effects on fertility: The present position. Brit. Med. Bull. 26(3):212-6, 1970. [ABST.: HAPAB 4:71-0739, 1971.] Roll, R. Studies of the teratogenic effect of 2,4,5-T in mice. Fd Cosmet. Toxicol. 9(5):671-6, 1971. TABST • HAPAB 5:72-0617. 1972.1 ------- Sare, W.M. and Forbes, P.I. Possible dysmorphogenic effects of an agricultural chemical: 2 4 5-T. n!z! Med. J. 75(476):37-8, 1972. [ABST.: HAPAB 6:Abst. #73-0085, 1973.] Shafik, M.T. et al. A method for determination of low levels of exposure to 2,4-D and 2,4,5-T. Int. J. Environ. Anal. Chem. 1:23-33, 1971. [ABST.: HAPAB 5:72-0845, 1972.] Sjoeden, P.O. and Soederberg, U. Sex-Dependent Effects of Prenatal 2,4,5-Trichlorophenoxy-Acetic Acid on Rats' Open-Field Behavior. Physiol. Behav. 9(3):357-60, 1972. [ABST.: HAPAB 6:Abst. #73-1959, 1973.] Sparschu, G.L. et al. Teratogenic study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Toxicol. Appl. Phamiacol. 17(1):317-18, 1970. [ABST.: HAPAB 3:70-2060, 1970.] Sparschu, G.L. et al. Study of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Fd Cosmet. Toxicol. 9(3):405-12, 1971. [ABST.: HAPAB 4:71-2699, 1971.] Sterling, T.D. Difficulty of evaluating the toxicity and teratogenicity of 2,4,5-T from existing animal experiments. Science 174(4016):1358-9, 1971. [ABST.: HAPAB 5:72-0431, 1972.] Stokinger, H.E. Sanity in research and evaluation of environmental health. Science 174(4010):662-5, 1971. [ABST.: HAPAB 5:72-0252, 1972.] Thomas, J.A. et al. - Actions of HTeTcTrin on the Uptake of Testosterone-l^-H-5 by Prostate Glands of the Male Mouse. Toxicol. Appl. Pharmacol. 22(2):326-7, 1972. [ABST.: HAPAB 6:Abst. #73-1217, 1973.] ------- Thompson, D.J. et al. Study of the eTfects of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) on rat and rabbit fetal development. Teratology 4(2):243, 1971. [ABST.: HAPAB 4:71-1999, 1971.J Walker, E.M. et al. Some effects oT-2,4,-D and 2,4,5-T on Ehrlich ascites tumor cells IN VIVO and IN VITRO. Ind. Med. Surg. 41(l):22-7, 1972. [ABST.: HAPAB 5:72-1048, 1972.] Williams, C.S. The current status of phenoxy herbicides. Down to Earth 27(4):20-4, 1972. 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