United States
Environmental Protection
Agency
Prevention, Pesticides
And Toxic Substances
(7508W)
EPA-738-F-94-004
April 1994
R.E.D. FACTS
Pesticide
Reregistration
Use Profile
Regulatory
History
Periplanone B
All pesticides sold or distributed in the United States must be
registered by EPA, based on scientific studies showing that they can be used
without posing unreasonable risks to people or the environment. Because of
advances in scientific knowledge, the law requires that pesticides which
were first registered years ago be reregistered to ensure that they meet
today's more stringent standards.
In evaluating pesticides for reregistration, EPA obtains and reviews a
complete set of studies from pesticide producers, describing the human
health and environmental effects of each pesticide. The Agency imposes
any regulatory controls that are needed to effectively manage each
pesticide's risks. EPA then reregisters pesticides that can be used without
posing unreasonable risks to human health or the environment.
When a pesticide is eligible for reregistration, EPA announces this and
explains why in a Reregistration Eligibility Decision (RED) document. This
fact sheet summarizes the information in the RED for Periplanone B.
Periplanone B, a biochemical pesticide, is the specific sex-attractant
pheromone of the American cockroach, Periplaneta americana. It currently
is used as a lure or bait in conjunction with another pesticide (propoxur) in
one registered pesticide product. Periplanone B has an extremely low use
rate of less than one microgram per bait. It is impregnated into bait
material that is pressed onto an open four-by-six inch tray. One of these
bait packages is used per 100 square feet of area to be treated.
Periplanone B was first registered as a pesticide in the U.S. in 1984.
Currently, only one product is registered which contains this active
ingredient, "Lure N Kill Roach and Ant Killer with Roach Sex Lure,"
which contains 0.001% Periplanone B and 10% propoxur. Because of its
nature and extremely low usage rate, EPA applied a reduced set of data
requirements for reregistration of Periplanone B.
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Human Health
Assessment
Environmental
Assessment
Toxicity
Acute mammalian toxicity studies on the currently registered end use
product indicate that Periplanone B is of low acute toxicity. It is placed in
Toxicity Category IV, indicating the lowest level of acute toxicity, for acute
oral and primary eye irritation effects. It is slightly to moderately toxic in
acute dermal, acute inhalation and primary dermal irritation studies, and has
been placed in Toxicity Category III for these effects. It is not a skin
sensitizer and does not cause mutagenic effects. Because the potential for
human exposure to Periplanone B is negligible, all other toxicology data
requirements are waived.
Dietary Exposure
The potential for dietary exposure to Periplanone B is considered
negligible because of its application method—its labeling prohibits
contamination of food—and because of the ultra-low amounts in the single
registered product.
Occupational and Residential Exposure
Since use of Periplanone B results in little exposure and does not pose
significant toxicological concerns, no exposure data are required.
Human Risk Assessment
The potential risks to humans from use of Periplanone B are
considered negligible due to the pesticide's application method (low volume
use in a bait product), low dietary and non-dietary exposure, and low level
of toxicity.
Environmental Fate
No environmental fate data are required for biochemicals like
Periplanone B, which cause no adverse effects in acute toxicology tests of
fish, birds and aquatic invertebrates.
Ecological Effects
EPA waived all ecological effects data requirements for Periplanone B
because this biochemical is used primarily indoors in very small quantities;
is a synthetic duplicate of a natural sex pheromone; and rapidly and
completely degrades to biologically inactive compounds when exposed to
light and air.
Ecological Effects Risk Assessment
Both environmental exposure and ecological risk are expected to be
negligible when Periplanone B is used according to label directions and
precautions.
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Additional Data The data base for Periplanone B is considered complete, and EPA is
RedUJr0d n°t requiring any additional generic or product specific studies. Only a new
Confidential Statement of Formula and revised labeling must be submitted
for reregistration of the product containing this pesticide.
Product Labeling
Changes Required
The single registered product containing Periplanone B must comply
with EPA's current pesticide product labeling requirements. In addition:
Application Rates - Product labeling must be revised to include a specific
maximum application rate:
"Use one baited tray per 100 square feet of surface to be treated or up
to X trays per 100 square feet if infestation is widespread."
Documentation of the rationale behind the maximum number of trays per
100 square feet must be submitted.
Replacement Directions - Labels must read:
"Replace insecticidal baits after 30 days to prevent cockroach
infestation."
Emphasize Non-Food Use - Use site labeling should say,
"For use in homes, for use in non-food areas of schools, theaters,
warehouses, motels, hotels, and commercial, industrial and
institutional establishments. For use in non-food areas of restaurants
and food-handling establishments."
Directions for Use - Add the word "residential" before "kitchen."
Regulatory
Conclusion
For More
Information
Use of the currently registered pesticide product containing
Periplanone B in accordance with approved labeling will not pose
unreasonable risks or adverse effects to humans or the environment.
Therefore, all uses of this product are eligible for reregistration. This
product will be reregistered once the required revised labeling is received
and accepted by EPA, and when the other active ingredient in the product
also is eligible for reregistration.
EPA is requesting public comments on the Reregistration Eligibility
Decision (RED) document for Periplanone B during a 60-day time period,
as announced in a Notice of Availability published in the Federal Register.
To obtain a copy of the RED document or to submit written comments,
please contact the Pesticide Docket, Public Response and Program
Resources Branch, Field Operations Division (7506C), Office of Pesticide
Programs (OPP), US EPA, Washington, DC 20460, telephone
703-305-5805.
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Following the comment period, the Periplanone B RED document will
be available from the National Technical Information Service (NTIS), 5285
Port Royal Road, Springfield, VA 22161, telephone 703-487-4650.
For more information about EPA's pesticide reregistration program,
the Periplanone B RED, or reregistration of individual products containing
Periplanone B, please contact the Special Review and Reregistration
Division (7508W), OPP, US EPA, Washington, DC 20460, telephone
703-308-8000.
For information about the health effects of pesticides, or for assistance
in recognizing and managing pesticide poisoning symptoms, please contact
the National Pesticides Telecommunications Network (NPTN). Call toll-
free 1-800-858-7378, from 8:00 am to 6:00 pm Central Time, Monday
through Friday.
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