December 16, 2004  8:30a.m. - 4:00p.m
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     Research  'for ihe

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                Presenters:
      STAR Grantees and Office of Research and
            Development Scientists
               Sponsored by:
      EPA Region 7 and EPA's National Center for
            Environmental Research
U.S. EPA Region 7 Office
901 N. 5th Street
Kansas City, Kansas
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Seminar Overview

Don't miss this one-day seminar to hear about new, intriguing
environmental research in the areas of Genomics,
Sustainability, and Remediation* This one seminar will
feature presentations from EPA's Science to Achieve Results
(STAR) grantees and Office of Research and Development
scientists.
                  "Rapid advances in genomics may have
                  significant implications for risk assessment
                  and regulatory decision making."
                                Draft EPA Document: Potential
                  Implications of Genomics for Regulatory and Risk
                     Assessment Applications at EPA, March 2004
"Pursuing the goal of sustainability allows us to use innovative
science and technology to achieve the goals of environmental and
economic prosperity for both current and future generations."
                                  Dr. Paul Gilman, Science Advisor
                                                    USEPA
Who Should Attend

Speakers and research projects were specifically selected to
address the needs and interests of federal, state, and tribal
environmental employees in Region 7. The purpose of this
seminar is to educate and engage discussion between
researchers and scientists from federal, state, and tribal
environmental programs on the latest state of the art in
environmental research. The seminar also will give researchers
in Region 7 the opportunity to discuss their research in the
context of EPA Region 7 environmental science needs and
priorities.

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Welcome to the "Second Environmental Research for the Future Seminar"
   "This year we have modified the format of our
   seminar to include discussions of how these
   important research topics relate to Region 7.
   We need your ideas and  new partnerships
   that  will ultimately  lead  us  to  scientific
   excellence.     I  know  you  will  find  the
   presentations very interesting and engaging.
   Thank you for being our allies in our efforts to
   achieve cleaner air,  purer water and better-
   protected land."
                                            James B. Gulliford
                     Regional Administrator, US EPA Region 7
                 "Welcome to the second of our research seminars
                 in Kansas City. This will be another opportunity to
                 interact  with some  of the  leading  scientists
                 conducting   research  on   issues   of   critical
                 importance  to your  region.  Researchers from
                 universities and ORD's laboratories will be here to
                 inform you  about cutting-edge  scientific  results
                 from their work in Region 7.  We are very excited
                 about  this seminar and hope that it will help you
                 gain  insight  and  understanding  about  these
                 interesting  and  innovative  research   projects.
                 Please join us at this special  event."
   Dr. William Farland
   Acting Deputy Assistant Administrator for Science,
   US EPA Office of Research and Development

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                                   AGENDA
8:30-9:00
Welcome
James B. Gulliford, Regional Administrator,
EPA Region 7
Dr. William Farland, Acting Deputy Assistant Administrator for
Science, EPA Office of Research and Development
 Sustainability
 9:00-9:45
 9:45-10:30



 10:30-11:15




 11:15-12:00



 12:00-1:00


 Genomics
 1:00-1:45




 1:45-2:30



 2:30-3:15
 3:15-4:00
                                     Room 2146
 Sustainability and the Future of Environmental Protection by Diana Bauer,
 EPA, Environmental Engineer, Office of Research and Development

 Attracting Private Developers to Brownfield Sites: The Value of
 Incentives by Kris Wernstedt, STAR grantee, Resources for the
 Future

 Site-specific Management Approaches and Revitalization Tools -
 Electronic (SMARTe) by Ann Vega, EPA, Brownfields Research
 Program Manager, Office of Research and Development

 Panel Discussion- Brownfields and Sustainability in Region 7
 - Kris Wernstedt, Ann Vega, Diana Bauer

 Lunch (on your own)
 Translating Genomics from Research to Risk Assessment by
 David Dix, EPA, Leader of Genomics Effects Team,
 Office of Research and Development

 Study of Phthalates in Pregnant Woman and Children by
 Shanna Swan, STAR Grantee, University of Missouri-
 Columbia

 USEPA Research Activities to Characterize Children's
 Environmental Exposures by Elaine A. Cohen-Hubal,
 EPA, Research Chemical Engineer, Office of Research and
 Development

 Panel Discussion- What does genomics research mean to Region 7?
 - David Dix, Shanna Swan, Elaine Cohen-Hubal
 Adjourn

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                            Side Session - Room 5160


Remediation
1:00 - 1:45               Efficacy and Risk Assessment of Phosphate-Based
                        Immobilization Technology in Lead Contaminated Soil in the
                        Missouri Jasper County Superfund Site by John
                        Yang, STAR Grantee, Lincoln University- University of
                        Missouri


1:45 - 2:30               ORD Speaker to be Determined


Adjourn

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                                 Sustainability
 :00 a.m. - 9:45 a.m.
                                                         Bauer
                              Sustainability and the Future of Environmental Protection
 Diana Bauer,
 EPA, Environmental
 Engineer, Off ice of
 Research and
 Development
Sustainability is balancing a growing economy, protection for the environment,
and social responsibility, so they together lead to an improved quality of life for
ourselves and future generations.

EPA is working in various ways to help individuals and organizations find
practical paths in the transition toward Sustainability:
      •Through science and engineering that enables monitoring, measuring,
      and tracking progress towards Sustainability.
      •Through science and engineering that forms the basis for design of the
      built environment, products, chemicals, and materials.
      •Through the science underlying market-driven approaches as a tool for
      environmental improvement.
      •Through partnerships with states, cities, communities, nonprofits,
      industry, and universities that encourage responsible use of our nation's
      resources.
      •Through futures analysis that investigates and anticipates trends critical
      for a sustainable environment, thereby strengthening EPA's ability to
      develop tools and strategies for Sustainability.
 :45a.m.- 10:30 a.m.
                                                    Wernstedt
Kris Wernstedt,
STAR Grantee,
Resources for the
Future
 Attracting Private Developers to Brownfield Sites:  The Value of Incentives

 Many brownfield properties have trouble attracting private capital. Left
 unattended, brownfield sites may further depress the economy of struggling
 neighborhoods. A growing number of public sector agencies have committed
 resources to incentives to encourage private investment in reusing
 contaminated sites. Because public funds are in short supply,  the relative
 effectiveness and efficiency of these incentives is an important issue for both
 public agencies and the development community.

 Our STAR-funded study surveyed 300 plus  private developers to  examine the
 relative attractiveness of incentives to promote redevelopment  of brownfields.
 Protection from third-party liability appears to offer the most value to developers,
 yet protection from cleanup liability and relief from public hearing requirements
 also have a substantial value as a  proportion of net project returns.  These
 values vary significantly depending on the experience of the respondents with
 brownfields and infill redevelopments.

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                             Sustainability
10:30 a.m.- 11:15 a.m.
                                    Vega
  Ann Vega
  EPA, Brownfields Research
  Program Manager, Office of
  Research and Development
Site-specific Management Approaches and Revitalization
           Tools - Electronic (SMARTe)

SMARTe is a web-based, decision support tool for
developing and evaluating plans for the redevelopment and
revitalization of potentially contaminated sites. SMARTe is
intended for all stakeholders with varying levels and types of
expertise. Brownfield project stakeholders should use
SMARTe to:

•Assess both market and non-market costs and benefits of
potential redevelopment/revitalization options,
•Clarify both private and public financing options,
•Evaluate and communicate environmental risks, and
•Facilitate communication among stakeholders.

When completed, SMARTe will provide the analytical tools
needed to implement and integrate each component of the
decision process allowing users to compare and evaluate
future reuse scenarios.
11:15 a.m. - Noon
                        Panel Discussion
                 Brnwnfields and
                 Sustainability in  Region

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                                    Genomics
1:00  p.m. - 1:45p.m.
                                                       Dix
   David Dix,
   EPA, Leader of
   Genomics Effects
   Team, Office of
   Research and
   Development
1:45 p.m. - 2:30  p.m.
     Translating Genomics from Research to Risk Assessment

Genomics is a rapidly expanding science with the potential to become a
powerful tool in regulatory decision-making, risk assessment, and
environmental monitoring. This presentation will review EPA policy
developments, define genomics and toxicogenomics, and provide a
history of the science as it relates to human health and ecological risk
assessments.  EPA has developed a genomics research program within
the Office of Research and Development (ORD), a complementary Interim
Pol icy on Genomics ( '. •    '  -;....   "•'-"•'»   ...     ,      ),
and a Genomics Task Force Workgroup, which produced a report on the
Potential Implications of Genomics for Regulatory and Risk Assessment
Applications at EPA (•     >i •   ,  -, <     •     HTli^sJrtm). Most
recently, the Science Policy Council created workgroups responsible for
developing guidance and training to foster the interpretation and use of
genomics information by EPA Program Offices and Regions.
                                                      Swan
   Shanna Swan,
   STAR Grantee,
   University of
   Missouri-Columbia
                 Can Phthalates Subtly Alter Boys?


   To identify a young rodent's gender without doing an elaborate test,
   biologists measure the distance from the animal's anus to its genital
   opening. This anogenital distance is slightly, but reliably, longer in
   males than in females—unless those males were exposed in the
   womb to pollutants, such as phthalates, that can alter fetal
   sex-hormone production. When that happens, a male's anogenital
   distance can become more similar to that of a female. Preliminary data
   suggest a similar trend in boys whose mothers were exposed during
   pregnancy to elevated amounts of some phthalates. " No one knows
   whether the anatomical  changes are important in the boys'
   reproductive lives.  In male rodents, however, fetal-phthalate
   exposures have been shown to severely disrupt the development of
   reproductive organs," notes Dr. Swan.

   Phthalates, chemicals used in making many cosmetics, plastics, and
   other products, have become ubiquitous pollutants.

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                               Genomics
:30 p.m. - 3:15p.m.
Elaine Cohen-Hubal,
EPA, Research Chemical
Engineer, Off ice of
Research and
Development
 15 p.m. -4:00 p.m.
                                   Cohen-Hubal
 Overview of EPA Research Activities Aimed at Characterizing
                 Children's Exposures

Given the potential vulnerability of children to the effects of
environmental exposures, understanding the relationship between
children's health outcomes and environmental exposures is an
important research need to reduce uncertainty in risk assessment.
Over the past 8 years, significant research activities have been
initiated at EPA to increase understanding of children's
vulnerabilities and to better characterize children's exposures to
chemical stressors in  the environment.

Research efforts include development of models, methods, and data
to quantitatively describe ways that children are exposed to
environmental stressors. Current and recently completed studies
include large field studies to measure children's exposures to
chemicals in their homes and daycare centers as well as targeted
studies to better understand the determinants of exposure. In this
presentation, ongoing and recent US EPA initiatives aimed at
evaluating children's exposures and health risks will be discussed,
including issues associated with characterizing cumulative risks from
exposures to multiple environmental stressors.
                              Panel Discussion
               What does  gennmins
               research mean to  Region
               7?

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                                 Remediation
1:00 p.m. - 1:45 p.m.
                                               Yang
   John Yang, Assistant
   Professor
   Star Grantee, Lincoln
   University- University
   of Missouri
   Efficacy and Risk Assessment of Phosphate-Based
 Immobilization Technology in Lead Contaminated Soil in
       the Missouri Jasper County Superfund Site

The mining and smelting operations of the lead-zinc ore from
the 1880s to the 1970s in the Tri-State Mining District
Superfund Site resulted in a large area of contaminated soil
and land.  In-situ immobilization technology using phosphate-
based amendments may be a cost-effective remediation
alternative that safeguards human health and the environment
from Lead (Pb) contamination. This presentation will address
Pb immobilization mechanisms; the efficacy of risk reduction
by soluble phosphates in laboratory studies; implementation
and evaluation of field treatment; and environmental risk
assessments in terms of bioavailability, leachability, chemical
speciation, microbial community,  and water quality.
1:45 p.m. - 2:30 p.m.
                                           Speaker

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               Seminar Specifics
For more information on this seminar contact Mandy Techau at
(913) 551-7311 or techau.mandy@epa.gov or Brenda
Groskinsky at (913) 551-7188 or groskinsky.brenda@epa.gov
Date:
Time:
Location:
Thursday, December 16, 2004
8:30 a.m. -4:00 p.m.
US EPA Region 7
901 N. 5th Street
Kansas City, KS
      ^tD 874
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