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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460
OFFICE OF
PREVENTION, PESTICIDES AND
TOXIC SUBSTANCES
Pesticide Fact Sheet
Name of Chemical: Thiencarbazone-methyl
Reason for Issuance: Conditional Registration
Date Issued: October 30, 2008
I. Description of Chemical
Chemical Name:
Common Name:
Chemical Formula:
EPA PC Code:
Chemical Abstracts
Service (CAS) Number:
Year of Initial
Registration:
Pesticide Type:
Chemical Class:
U.S. Producer:
Methyl 4-[(4,5-dihydro-3-methoxy-4-methyl-5-oxo-lH-
l,2,4-triazol-l-yl)carboxamidosulfonyl]-5-
methylthiophene-3-carboxylate
Thiencarbazone-methyl
OCH,
015804
317815-83-1
2008
Herbicide
sulfonyl-amino-carbonyl-triazolinone
Bayer CropScience
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II. Use Patterns and Formulations
Application Sites:
Thiencarbazone-methyl is registered for use on corn (field, sweet,
pop), wheat, and turf and ornamentals in residential settings
Types of Formulations: Thiencarbazone-methyl Technical, 97.58% technical grade
SC 450 Herbicide, 19.23% flowable concentrate formulation
SC 450 Turf & Ornamental, 19.23% flowable concentrate formulation
WG 63 Herbicide 21% water dispersable granule formulation
WG 63 Turf & Ornamental, 21% water dispersable granule formulation
OD 70 Herbicide 1.0% oil dispersion formulation;
SC 465 Herbicide 7.6% flowable concentrate formulation
SC 547 Herbicide 5.6% flowable concentrate formulation
Application Methods
And Rates:
Thiencarbazone-methyl may be applied to corn as preplant,
preemergence, or postemergence applications at maximum total
seasonal rates of 0.040 Ib ai/A, with a 45-day preharvest interval
(PHI) and a 14-day retreatment interval (RTI). It may also be
applied as a single postemergence application to spring wheat at
0.0044 Ib ai/A, with PHIs of 7 days for forage and hay and 60 days
for grain and straw. Agricultural crop applications are allowed by
ground and aerial equipment. Thiencarbazone-methyl may also be
applied to turf and ornamentals at maximum total seasonal rates of
0.040 Ib ai/A. Applications to turf and ornamentals are allowed
only by ground equipment and are not permitted to be applied
through irrigation systems.
III. Physical and Chemical Properties:
Table 1 ~ Physical and Chemical Properties
Melting point
PH
Density
Water solubility at 20°C
Solvent solubility at 20°C
of Thiencarbazone-methyl
206 °C
3. 8 at 22.4 °C
1.51, relative to water at 4 °C
72 mg/L in pure water
172 mg/L at pH 4
436 mg/L at pH 7
4 17 mg/L at pH 9
Ethanol
n-Hexane
Toluene
Dichloromethane
Acetone
Ethyl acetate
Dimethyl sulfoxide
g/L
0.23
0.00015
0.19
100-120
9.54
2.19
29.15
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Table 1 ~ Physical and Chemical Properties of Thiencarbazone-methyl
Vapor pressure
Dissociation constant, pKa
Octanol/water partition coefficient,
Log(K0w)
UV/visible absorption spectrum
~9 x 10'14 Pa (20 °C, extrapolated)
3.0
-0.13 atpH4, 24 °C;
-1.98atpH7, 24 °C;
-2. 14 at pH 9, 23 °C
No significant light absorbance at >290 nm
IV. HUMAN HEALTH RISK ASSESSMENT
A. Toxicity
1. Acute Toxicity: Thiencarbazone-methyl has low acute toxicity via the oral, dermal or
inhalation routes of exposure. Thiencarbazone-methyl is not an eye or skin irritant and is
not a skin sensitizer to guinea pigs. The acute toxicity findings for thiencarbazone-methyl
are summarized below in Table 2:
Table 2 Acute Toxicity
Acute Toxicity of Thiencarbazone-methyl
Guideline
No.
870.1100
870.1200
870.1300
870.2400
870.2500
870.2600
Study Type
Acute Oral - rat
Acute Dermal - rat
Acute Inhalation - rat
Primary Eye Irritation -
rabbit
Primary Skin Irritation -
rabbit
Dermal sensitization -
guinea pig
Results
LD50 > 2000 mg/kg
LD50 > 2000 mg/kg
LC50>2.018mg/L
Not an irritant to the eye
Not an irritant to the skin
Not a dermal sensitizer
Toxicity
Category
III
III
III
IV
IV
N/A
2. Subchronic and Chronic Toxicity: The most lexicologically significant effect of
thiencarbazone-methyl occurs in the urothelial system including the kidney, bladder,
and urinary tract. Across species, the dog is more sensitive than the rat or the mouse,
with the older animals being most affected. The toxicity to the urothelial system
starts from the formation of calculi and stones which result in irritation and lead to
potentially fatal nephropathy and in some cases neoplasia. Most other effects of
thiencarbazone-methyl were considered secondary to the stress caused by the
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nephropathy. Common lesions in the urothelial tract include sulfonamide crystals
(also stones and calculi of the parent compound), eosinophilic urolithiasis,
hyperplasia, congestion, hemorrhage, inflammation, infiltrations and ulceration.
3. Carcinogenicity: Thiencarbazone-methyl is classified as "Not likely to be a
Carcinogen to Humans at doses that do not cause urothelial cytotoxicity." No
treatment-related increases in neoplasia occurred in the rat carcinogenicity study. In
mice, at 599 mg/kg/day in males and 758 mg/kg/day in females, doses where there
was formation of calculi in the urothelial system, thiencarbazone-methyl was
associated with transitional cell epithelium tumors in the urinary bladder in one male
and three females and in the prostatic urethra in one male. Since the neoplasia
occurred only in the high dose group, thiencarbazone-methyl was classified as "Not
likely to be a Carcinogen to Humans at doses that do not cause urothelial
cytotoxicity".
4. Prenatal and Postnatal Sensitivity: There is no indication of increased
susceptibility of rat or rabbit offspring to thiencarbazone-methyl as indicated by the
rat and rabbit developmental toxicity studies and the rat reproduction study. There is
no concern for increased susceptibility to offspring.
5. Metabolism: Thiencarbazone-methyl was demonstrated to be rapidly absorbed from
the gastrointestinal tract (with peak plasma levels after about one hour) although
absorption represented only 48-55% of the administered dose. Retention was
minimal (< 1% at 14 hours) and depending upon the location of the label, slightly
more was found in the lungs and fat (thiophene label) and in the adrenals and thyroid
(dihydrotriazole label). There was some evidence based on quantitative
autoradiography of persistent residues in the nasal mucosa. The metabolism of
thiencarbazone-methyl was limited since 91-92% of the administered dose was
recovered as intact parent. Three minor metabolites were found from the thiophene
label and five were found from the dihydrotriazole label. The postulated route of
metabolism proceeds as: i. initial hydrolysis of the urea group releasing the
thiophene-sulphonamide moiety; ii. hydrolysis of the methyl ester releases the
sulphonamide-carboxylic acid that is subsequently cyclised to thienosaccharine; iii. a
second metabolic pathway includes hydrolysis of thiencarbazone-methyl to the MMT
derivative (5-methoxy-4-methyl-2,4-dihydro-3H-l,2,4-triazol-3-one) which can be
further degraded to methyl carbamate.
6. Mutagenicity: None of the battery of mutagenicity or genetic toxicity studies for
thiencarbazone-methyl indicated a positive result.
7. Toxicology Profile: The toxicological profile for thiencarbazone-methyl is discussed
in Table 3 below:
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Table 3 Subchronic, Chronic and Other Toxicity Profile for Thiencarbazone-methyl
Guidelin
e No.
Study Type
MRID No. (year)/
Classification /Doses
Results
870.3100
90-Day oral
toxicity - rat
47070126 (2003)
Acceptable/Guideline
0, 400, 2000 or 7000
ppm.
M: 0, 24.7, 123 or
439 mg/kg/day.
F: 0,30.8, 154 or 543
mg/kg/day.
NOAEL = 123 in males and 154
mg/kg/day in females.
LOAEL = 439 in males and 543
mg/kg/day in females based on
urothelial effects. .
870.3100
90-Day oral
toxicity - mouse
47070127(2004)
Acceptable/Non-
Guideline
0, 500, 2000 or 4000
ppm.
M: 0,76, 315 or 637
mg/kg/day.
F:0, 103, 409 or 789
mg/kg/day.
NOAEL = 315 mg/kg/day in males but
789 mg/kg/day in females.
LOAEL = 637 mg/kg/day in males
based on urothelial effects. .
870.3150
90-day oral
toxicity - dogs
47070129 (2005)
Acceptable/Guideline
0, 1000, 5000 or
10000 ppm.
M: 0,34, 149 or 335
mg/kg/day.
F:0, 32, 159 or 351
mg/kg/day,
NOAEL = 149 in males and 159 in
females mg/kg/day.
LOAEL = 335 in males and 351 in
females mg/kg/day based on urothelial
effects.
870.3700
a
Prenatal
developmental
in rats
47070130(2005)
Acceptable/Guideline
0, 50, 200 or 1000
mg/kg/day.
Maternal NOAEL = 200 mg/kg/day
LOAEL = 1000 mg/kg/day based on
body weight loss, decreased placenta
weight, yellowish sediment in the
urothelial system (probably the test
material).
Developmental NOAEL = 200
mg/kg/day
LOAEL = 1000 mg/kg/day based on
reduced fetal weight and decreased
ossification at several skeletal
locations.
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Table 3 Subchronic, Chronic and Other Toxicity Profile for Thiencarbazone-methyl
Guidelin
e No.
Study Type
MRID No. (year)/
Classification /Doses
Results
870.3700
b
Prenatal
developmental
in
Rabbits.
47070131 (2006).
Acceptable/Guideline
0, 50, 125 or 500
mg/kg/day.
Maternal NOAEL = 125 mg/kg/day
LOAEL = 500 mg/kg/day based on
mortality, weight loss, reduced food
consumption and sediment in the
urothelial system (probably the test
material).
Developmental NOAEL = 125
mg/kg/day
LOAEL = 500 mg/kg/day based on runt
fetuses and white sediment in the
kidney of one fetus.
870.3800
Reproduction
and fertility
effects
rat
47070132 (2006)
Acceptable/Guideline
0, 500, 2500 or 10000
ppm.
M: 0, 46, 245, or
945.8 for FO and 0,
50.2, 260.5 or 992.1
forFl mg/kg/day.
F:0, 55.6, 263.7 or
968.4 for FO and 0,
68,353.1 or 1284.0
forFl mg/kg/day.
Parental/Systemic NOAEL = 245 and
264 mg/kg/day
LOAEL = 946.8 and 968.4 mg/kg/day
based on mortality, clinical signs and
urothelial effects.
Reproductive NOAEL = 992.1 for
males and 1284 for females mg/kg/day.
No effects at HOT.
Offspring NOAEL = 245 in males and
264 in females mg/kg/day.
LOAEL = 946.6 in males and 968.4 in
females mg/kg/day based on
macroscopic alterations in the kidney
and bladder. .
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Table 3 Subchronic, Chronic and Other Toxicity Profile for Thiencarbazone-methyl
Guidelin
e No.
Study Type
MRID No. (year)/
Classification /Doses
Results
870.4100
a
Chronic toxicity
Rat
47070134 (2007)
Acceptable/Guideline
0, 500, 2500 or 5000
ppm.
M: 0, 10.6, 27.2,
136.4
or268.6mg/kg/day
for one year and 0,
22.8, 115.2 or 234
mg/kg/day for two
years,
F:0, 13.2,35.8, 176.7
or 366.6 mg/kg/day
for one year and 0,
29.9, 152.9 or 313.4
mg/kg/day for two
years. .
NOAEL = 234 for males and 313.4 for
females mg/kg/day - no effects at the
highest dose tested.
870.4100
b
Chronic toxicity
(dog)
47040133 (2007)
Acceptable/Guideline
0, 1000, 4000 or
8000/7000/6000 ppm.
M: 0,29, 117 or 179
mg/kg/day.
F:0, 27, 127 or 200
mg/kg/day.
NOAEL = 117 for males and 127 for
females mg/kg/day
LOAEL = 179 for males and 200 for
females mg/kg/day based on urothelial
effects.
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Table 3 Subchronic, Chronic and Other Toxicity Profile for Thiencarbazone-methyl
Guidelin
e No.
Study Type
MRID No. (year)/
Classification /Doses
Results
870.4200
Carcinogenicity
(rat)
47070134 (2007)
Acceptable/Guideline
0, 500, 2500 or 5000
ppm.
M: 0, 10.6, 27.2,
136.4
or268.6mg/kg/day
for one year and 0,
22.8, 115.2 or 234
mg/kg/day for two
years,
F:0, 13.2,35.8, 176.7
or 366.6 mg/kg/day
for one year and 0,
29.9, 152.9 or 313.4
mg/kg/day for two
years. .
No evidence of carcinogenicity
870.4300
Carcinogenicity
(mouse)
47070216 (2006)
Acceptable/Guideline
0,200, 1000 or 4000
ppm
M: 0, 29.2, 147 or
599 mg/kg/day.
F: 0,36..8, 185 or
758 mg/kg/day.
NOAEL = 147 for males and 185 for
females mg/kg/day
LOAEL = 599 for males and 758 for
females mg/kg/day based on urothelial
effects.
Transitional cell epithelial tumors in the
urinary bladder in one male and three
females and in the prostatic urethra in
one male.
Gene
Mutation
870.5100
Ames test
47070137 (2005)
Acceptable/Guideline
Negative up to 400 jig/plate.
Gene
Mutation
870.5100
Ames test
47070136 (2007)
Acceptable/Guideline
Negative up to 512 jig/plate
Forward
mutation
870.5300
V79/HPRT test
47070140(2007)
Acceptable/Guideline
Negative at 600 |ig/mL.
Forward
mutation
870.5300
Forward
mutation
47070141 (2005)
Negative
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Table 3 Subchronic, Chronic and Other Toxicity Profile for Thiencarbazone-methyl
Guidelin
e No.
Study Type
MRID No. (year)/
Classification /Doses
Results
Chromos
ome
ab erratic
n
870.5375
Chinese hamster
ovary cells.
47070144(2007)
Negative
Chromos
ome
ab erratic
n
870.5375
Chinese hamster
ovary cells
47070145 (2005)
Negative
Micronuc
leus test
870. 5395
Mouse
47070214 (2004)
No evidence of clastogenic effect at
doses up 500 mg/kg.
870.6200
a
Acute
neurotoxicity
screening
battery
47070148 (2006)
Acceptable/Guideline
0, 131 512or2180
mg/kg/day.
NOAEL = 512 mg/kg/day
LOAEL = 2180 mg/kg/day based on
decreased motor and locomotor activity
in both sexes (not definitely a
neurotoxic effect).
870.6200
b
Subchronic
neurotoxicity
screening
battery
47070149(2006)
Acceptable/Guideline
0, 500, 2000, 6000
ppm
M: 0,33.1, 137 or
411 mg/kg/day.
F: 0,42.4, 171 or 527
mg/kg/day.
NOAEL = 411 in males and 527 in
females mg/kg/day. No effects at the
highest dose tested.
870.7485
Metabolism and
pharmacokineti
cs
(species)
47070159 (2006)and
47070201(2006)
Acceptable/Guideline
Adsorption, excretion, retention (very
little) and metabolites identified.
8. FQPA Hazard Considerations: EPA has determined that reliable data show that it
would be safe for infants and children to reduce the FQPA safety factor to IX. That
decision is based on the following findings:
The toxicology database for thiencarbazone-methyl is complete except for
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immunotoxicity studies (series 870.7800), a new requirement to characterize the
toxicity of pesticides. Review of the thiencarbazone-methyl toxicity database did
not reveal any indication of specific effects on the immune system, even at the
highest doses tested. In addition, thiencarbazone-methyl does not belong to a
class of chemicals that would be expected to be immunotoxic. Therefore, based
on the above considerations, HED does not believe that conducting a special
series 870.7800 immunotoxicity study will result in a NOAEL less than the
NOAEL of 117 mg/kg/day already set for thiencarbazone-methyl and an
additional uncertainty factor for database uncertainties (UFDB) does not need to
be applied.
There is no pre- or post-natal susceptibility.
There are no residual uncertainties identified in the exposure databases
The exposure assessment is protective: the chronic dietary food exposure
assessment utilizes tolerance level residues, assume 100% of crops with requested
uses of thiencarbazone-methyl are treated, and employ default processing factors.
The drinking water assessment generated estimated drinking water concentrations
(EDWCs) using models and associated modeling parameters which are designed
to provide conservative, health protective, high-end estimates of water
concentrations. The highest relevant EDWCs were used in the dietary (food and
drinking water) exposure assessment
By using these screening-level exposure assessments in the chronic dietary (food
and drinking water) assessments, risk is not underestimated.
9. Toxicological Endpoints: A summary of the toxicological endpoints and doses
chosen for the relevant exposure scenarios for dietary, residential, and occupational
human health risk assessments is provided in the table below. The conventional
interspecies extrapolation (10X) and intraspecies variation (10X) uncertainty factors
were applied for all exposure scenarios. As stated above, the FQPA SF for increased
susceptibility was reduced to IX for all exposures scenarios. A summary of the
toxicological endpoints are shown below in Table 3:
Table 4 ~ Summary of Toxicological Doses and Endpoints for Thiencarbazone-methyl
for Use in Human Health Risk Assessments
Exposure/Scenario
Acute Dietary (All
populations)
Chronic Dietary (All
populations)
Dose Used in
Risk
Assessment
Uncertainty/FQPA
Safety Factors
Study and
Toxicological Effects
No selection because no indication of significant toxicity following a single
dose.
NOAEL= 117
mg/kg/day
UFA= lOx
UFH= 10x
FQPASF= Ix
Dog chronic feeding study
LOAEL = 177 mg/kg/day
10
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Exposure/Scenario
Incidental Oral Short-and
Intermediate-Term (1-30
days and 1-6 months)
Dermal Short- and
Intermediate-Term (1-30
days and 1-6 months)
Dermal Long-Term (>6
months)
Inhalation Short and
Intermediate Term (1-30
days and 1-6 months)
Dose Used in
Risk
Assessment
NOAEL= 159
mg/kg/day
NOAEL= 159
mg/kg/day
NOAEL=117
mg/kg/day
NOAEL= 159
mg/kg/day
Uncertainty/FQPA
Safety Factors
UFA= lOx
UFH=10x
FQPA SF= Ix
UFA= lOx
UFH=10x
FQPA SF= Ix
UFA= lOx
UFH=10x
FQPA SF= Ix
UFA= lOx
UFH=10x
FQPA SF= Ix
Study and
Toxicological Effects
based on urothelial effects.
Dog subchronic study
LOAEL = 335 mg/kg/day in
males and 351 mg/kg/day in
females based on urothelial
effects.
Dog subchronic study
LOAEL = 335 mg/kg/day in
males and 351 mg/kg/day in
females based on urothelial
effects.
Dog chronic feeding
LOAEL = 177 mg/kg/day
based on urothelial effects.
Dog subchronic study
LOAEL = 335 mg/kg/day in
males and 351 mg/kg/day in
females based on urothelial
effects.
Cancer Classification: "Not Likely to be Carcinogenic to Humans at doses that do not cause urothelium
(oral, cytotoxicity."
dermal,
inhalation)
UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies). UFH = potential variation in
sensitivity among members of the human population (intraspecies). UFFQPA = FQPA Safety Factor. NOAEL = no
observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA =
extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity among members of the
human population (intraspecies). FQPA SF = FQPA Safety Factor.
B. Dietary Exposure and Risk
1. Dietary Exposure from Food: As to residues in food, EPA relied upon tolerance
level residues and assumed 100% crop treated for all commodities for chronic
exposures.
2. Dietary Exposure from Water: Drinking water was incorporated directly into the
chronic dietary assessment using the chronic concentration for surface water
generated by the FIRST model. Modeled estimates of drinking water concentrations
were directly entered into the dietary exposure model. For the chronic dietary risk
assessment, the water concentration value of 0.36 |ig/L was used to assess the
contribution to drinking water.
11
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It was determined that the residue of concern in drinking water for risk assessment
purposes is the parent only.
3. Aggregate Exposure Risk Assessments: For thiencarbazone-methyl, aggregate
exposure risk assessments were performed for the following scenario: chronic
aggregate exposure (food and drinking water) and short-term aggregate exposure
(averaged food & drinking water with oral, dermal and inhalation residential
exposures). An acute aggregate risk assessment was not conducted due to the lack of
an acute toxicity endpoint. A long-term aggregate risk assessment was not conducted
because the dietary route alone is relevant for long-term/chronic exposure and risk
assessment. A cancer aggregate risk assessment was not conducted based on the
classification that thiencarbazone-methyl is not likely to be carcinogenic to humans at
doses that do not cause urothelium cytotoxicity.
4. Chronic Aggregate Risk: The exposure to thiencarbazone-methyl from food and
water will utilize less than 0.1% of the cPAD for the general U.S. population and
0.1% of the cPAD for children 1-2 years old, the most highly exposed population
subgroup. Therefore, the chronic aggregate risk associated with the proposed uses of
thiencarbazone-methyl are not of concern to the general U.S. population or any
subgroup. A summary of the chronic dietary exposure analyses is shown in Table 4
below:
Table 5 ~ Summary of the Dietary Exposure and Risk to Thiencarbazone-methyl
Population Subgroup
U.S. Population
All infants (< 1 yr)
Children l-2yrs
Children 3-5 yrs
Children 6-12 yrs
Youth 13-1 9 yrs
Adults 20-49 yrs
Adults 50+ yrs
Females 13-49 yrs
PAD, mg/kg/day
1.17
Chronic Dietary Risk
Dietary Exposure,
mg/kg/day
0.000194
0.000320
0.000856
0.000594
0.000367
0.000180
0.000117
0.000103
0.000118
%cPAD
<0.1
<0.1
0.1
0.1
<0.1
<0.1
<0.1
<0.1
<0.1
5. Short-Term Aggregate Risk:
To determine the thiencarbazone-methyl short-term aggregate risk, the averaged food
& water exposures were combined with the oral, dermal and inhalation residential
exposures. The results indicate that aggregate risk estimates are not of concern for
adults and children. Additionally, this analysis demonstrates that residential
12
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exposures comprise most of the expected short-term exposures to thiencarbazone-
methyl. A summary of the short-term aggregate exposure analysis is shown in Table
6 below:
Table 6 Short-Term Aggregate Risk Calculations
Population
Adult
Child
Short-Term Scenario
NOAEL
mg/kg/day
159
159
LOC1
100
100
Max
Allowable
Exposure2
mg/kg/day
1.59
1.59
Average
Food&
Water
Exposure3
mg/kg/day
0.000194
0.000856
Residential
Exposure4
mg/kg/day
0.00831
0.0109
Aggregate MOE
(food and
residential)5
18,700
13,500
1 Based on the standard inter- and intra- species uncertainty factors totaling 100.
2 Maximum Allowable Exposure (mg/kg/day) = NOAEL/LOC
3 Adults from U.S. Population and Child from Children 1-2 years old.
4 Residential Exposure = [Oral exposure + Dermal exposure + Inhalation Exposure].
5 Aggregate MOE = [(NOAEL /(Avg Food & Water Exposure + Residential Exposure)]
6. Cumulative Risk: Although thiencarbazone-methyl has in common with other
sulfonamide chemicals, including cyprosulfamide, the ability to cause urinary tract
stones and in some cases tumors in the urinary tract (only at high doses), EPA has not
made a common mechanism finding for thiencarbazone-methyl such that cumulative
risk assessment based on chemicals with a common mechanism is necessary for
cyprosulfamide and thiencarbazone-methyl. This decision is based on the assumption
that cyprosulfamide and thiencarbazone-methyl are not additive with regard to the
formation of urinary tract stones at anticipated exposure levels.
C. Handler and Worker Risk Assessments
1. Worker Exposure: Based on the proposed use patterns, there is a potential for
exposure to thiencarbazone-methyl during mixing, loading, and application activities.
Short-term and intermediate-term (1-30 days and 1-6 months), dermal, inhalation and
incidental oral (for toddlers) exposures were estimated. The proposed uses of
thiencarbazone-methyl involves application to agricultural crops as well as turf
(residential and commercial lawns) and ornamentals (landscapes, commercial
greenhouses, and nurseries). Thiencarbazone-methyl is also intended for non-
agricultural use sites (e.g., golf course) to which the WPS does not apply; the labels
appropriately contain language cautioning unprotected persons to keep out of treated
areas until sprays have dried.
2. Applicator and Mixer Loader Risk Assessment: There is a potential for exposure
to thiencarbazone-methyl during mixing, loading, and application activities. Chronic
exposure is not expected for the proposed use patterns associated with thiencarbazone
13
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-methyl. Estimated short- and intermediate-term dermal, inhalation and incidental
oral (for toddlers) exposures were compared to the oral NOAEL of 159 mg/kg/day
from a subchronic feeding - dog toxicity study in which no effects were observed at
highest dose tested. 100% absorption via the dermal and inhalation routes of
exposure is assumed, resulting in very conservative estimates of risk. Where
appropriate, dermal, inhalation, and incidental oral MOEs were combined into total
MOEs because the same dose and endpoint were chosen to evaluate all routes of
exposure. The FQPA safety factor was removed (i.e., reduced to Ix) for all potential
exposure scenarios; therefore, the level of concern (LOG) for both non-occupational
and occupational risk is for margins of exposure (MOEs) <100. The results of the
handler occupational exposure and risk assessment indicate that risks are not of
concern with baseline clothing, or when gloves are worn (which is required on the
proposed labels). The total short/intermediate-term MOEs range from 100 to
858,000; which reach or exceed the LOG of 100, and are not of concern.
Exposure/risks for short and intermediate-term dermal and inhalation exposures at
baseline are presented in Table 7 below:
Table 7 ~ Summary of Short- and Intermediate-Term Occupational Exposure and Risk
Estimates for Thiencarbazone-methyl
Table 7: Short and Intermediate-Term Risk Assessment For Agricultural Uses of Thiencarbazone -methyl
Exposure
Scenario
(Scenario #)
(1)
Mixing/Loading
Liquid for
Aerial
application
(2)
Mixing/Loading
Liquid for
Groundboom
application
(3)
Mixing/Loading
Liquid for
Aerial
application
(4)
Mixing/Loading
Liquid for
Groundboom
application
Dermal Unit
Exposure (mg/lb ai) 1
Baseline
2.9
2.9
2.9
2.9
PPE
(gloves)
0.023
0.023
0.023
0.023
Inhalation
Unit
Exposure
(mg/lb ai)2
0.0012
0.0012
0.0012
0.0012
Use Site
Com
Com
Spring wheat
Spring wheat
Application
Rate
(Ib ai/A)3
0.033
0.033
0.0044
0.0044
Area
Treated
(A/day)4
1200
200
1200
200
Total
Short-/Int-term MOE 5
Baseline
100
580
727
4,360
PPE
(gloves)
-
-
-
-
14
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Table 7: Short and Intermediate-Term Risk Assessment For Agricultural Uses of Thiencarbazone -methyl
Exposure
Scenario
(Scenario #)
(5)
Mixing/Loading
Water soluble
granular for
Aerial
application
(6)
Mixing/Loading
Water soluble
granular for
ground boom
application
(7) Applying
Sprays with
Fixed- wing
Aircraft (closed
cab)
(8) Applying
Sprays with
Open Cab
Groundboom
(9) Flagging to
Support Aerial
Applications
Dermal Unit
Exposure (mg/lb ai) 1
Baseline
0.066
0.066
0.005
Eng.C
0.005
Eng.C
0.014
0.014
0.011
0.011
PPE
(gloves)
0.066
0.066
-
-
Inhalation
Unit
Exposure
(mg/lb ai)2
0.00077
0.00077
0.000068
0.000068
0.00074
0.00074
0.00035
0.00035
Use Site
Com
Com
Com
Spring wheat
Com
Spring wheat
Com
Spring wheat
Application
Rate
(Ib ai/A)3
0.013
0.013
0.033
0.0044
0.033
0.0044
0.013
0.0044
Area
Treated
(A/day)4
1200
200
1200
1200
200
200
350
Total
Short-/Int-term MOE 5
Baseline
10,700
64,112
-
-
114,500
858,000
210,500
637,000
PPE
(gloves)
-
-
55,500
Eng.C
416,000
Eng.C
-
-
-
-
15
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Table 7: Short and Intermediate-Term Risk Assessment For Agricultural Uses of Thiencarbazone -methyl
Exposure
Scenario
(Scenario #)
(10)
Mixing/Loading
Liquid and
Applying with
Handgun
Sprayer
(11)
Mixing/Loading
Liquid and
Applying with
Low-Pressure
Handwand
(12)
Mixing/Loading
Liquid and
Applying with
High-Pressure
Handwand
(13)
Mixing/Loading
Liquid and
Applying with
Backpack
Sprayer
(14)
Mixing/Loading
water soluble
granular and
Applying with
Backpack
Sprayer,
handgun
sprayer, low
pressure
handwand or
high pressure
handwand.
Dermal Unit
Exposure (mg/lb ai) 1
Baseline
no data
100
no data
no data
no data
PPE
(gloves)
0.50
0.43
2.5
2.5
no data
Inhalation
Unit
Exposure
(mg/lb ai)2
0.0019
0.03
0.12
0.03
no data
Use Site
Turf
Turf
Ornamentals
Turf
Ornamentals
Turf
Application
Rate
(Ib ai/A)3
0.027
0.01
(Ib ai/gal)
0.01
(Ib ai/gal)
0.01(lb
ai/gal)
0 01
(Ib ai/gal)
O.OOSlb ai/A
Area
Treated
(A/day)4
5
40
(gal/day)
1,000
(gal/day)
40
(gal/day)
40
(gal/day)
40
(gal/day)
or
5A/Day
Total
Short-/Int-term MOE 5
Baseline
no data
278
no data
no data
no data
No
Assessment
PPE
(gloves)
164,000
-
425
11,000
11,000
No
Assessment
1 Baseline dermal unit exposure values represent long pants, long sleeved shirts, shoes, and socks; PPE values represent the addition of chemical-
resistant gloves for those scenarios in which the MOEs do not reach 100 at baseline or those for which data are not available without gloves.
Values are reported in the PHED Surrogate Exposure Guide dated August 1998, except for the handgun value which was obtained from ORETF.
2 Inhalation unit exposure values represent no respirator. Values are reported in the PHED Surrogate Exposure Guide dated August 1998.
3 Application rates are based on maximum values found in proposed labels
4 Daily area treated is based on the area or gallons that can be reasonably applied in a single day for each exposure scenario of concern based on
the application method and formulation/packaging type, (standard EPA/OPP/HED values).
5 ShorWIntermediate-Term MOE = NOAEL (159 mg/kg/day) / (Daily Dermal Dose + Daily Inhalation Dose). The LOC is 100.
Note. Daily Dose (mg/kg/day) was calculated by Unit Exposure * 100% Absorption * Application rate * Area treated} / 70 kg; where dermal
absorption is 100% and inhalation absorption is assumed to be 100%.
16
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3. Postapplication Handler Risk Assessment: Postapplication inhalation exposure is
expected to be negligible; however, dermal exposure is possible for workers entering
treated areas to tend or harvest crops, mow/maintain turfgrass, or tend ornamentals in
nurseries and greenhouses. In addition to DFR and TTR, transfer coefficients (Tc)
are used to relate the residue values to activity patterns, which take place after
application, to estimate potential human exposure. The transfer coefficients used in
this assessment are from an interim transfer coefficient guidance document developed
by HED's Science Advisory Council for Exposure using proprietary data from the
Agricultural Re-entry Task Force (ARTF) database (SOP# 3.1). A summary of
occupational short and intermediate-term post-application risks associated with the
proposed uses of thiencarbazone-methyl are presented in Table 8a and 8b below:
Table 8a & b Summary of Short and Intermediate-Term Occupational Post-Application
Risks for Thiencarbazone-methyl
Table 8a Summary of Estimated Post-application MOEs for Agricultural Crops
Crop
Spring Wheat
Corn
Application
Rate
(Ib ai/A) l
0.0044
0.033
DAT
2
0
0
DFR3
(jig/cm2)
0.0098
0.076
TC4
(cm2/hr)
100
1500
400
1000
17000
Activity 4
Hand weeding, scouting
Scouting, irrigation
Scouting
Irrigation
Hand harvesting,
Detasseling
Short-
/Int-
Term
MOE5
1,400,000
94,000
47,000
19,000
1,100
Maximum application rate from proposed labels
DAT = Days after treatment needed to reach the LOG of 100; DAT 0 = the day of treatment, after sprays have dried; assumed to be
approximately 12 hours.
3 DFR (ug/cm2) = dislodgeable foliar residues corresponding to DAT, based on 20% of application rate.
4 TC (cm2/hr) = transfer coefficients and associated activities from ExpoSAC Policy Memo #003.1 "Agricultural Transfer Coefficients",
8/17/2000.
5 MOE = MOE on the corresponding DAT. MOE = NOAEL / Daily Dose. Values in bold indicate when 1 day, or longer, is necessary
for the MOE to reach 100.
Daily Dose = [(TTR or DFR x TC x 100% Dermal absorption x 8-hr Exposure Time)] / [(CF: 1000 ug/mg) x (70-kg Body Weight)]
Short-/intermediate-term NOAEL = 159 mg/kg/day. The LOC is 100.
Table 8b. Summary of Estimated Post-application MOEs for Turf and Ornamentals
Crop
Application
Rate
(Ibai/A)1
DAT
2
TTR or
DFR3
(jig/cm2)
TC4
(cm2/hr)
Activity 4
Short-
/Int-
Term
MOE5
Turf
Turf
0.027
0
0.015
3,400
6,800
Mowing and other maintenance activities
Sod harvesting and transplanting
27,000
13,500
17
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Table 8b. Summary of Estimated Post-application MOEs for Turf and Ornamentals
Crop
Application
Rate
(Ibai/A)1
DAT
2
TTRor
DFR3
(jig/cm2)
TC4
(cm2/hr)
Activity 4
Short-
/Int-
Term
MOE5
Ornamentals - Nursery Stock
Nursery
Stock
0.027
0
0.015
100
400
Hand pruning containerized ornamentals
Harvesting, ball/burlap containerized
ornamentals
920,000
230,000
Ornamentals - Cut Flowers
Cut
Flowers
0.027
0
0
0.015
0.015
500
5,100
Pinching
Hand harvesting, pruning, thinning,
pinching
184,000
18,000
Maximum application rate from proposed labels
2 DAT = Days after treatment needed to reach the LOG of 100; DAT 0 = the day of treatment, after sprays have dried; assumed to be
approximately 12 hours.
3 Turf transferable residues: TTR (ug/cm2) = Application rate (Ib ai/A) x CF (4.54E+8 ug/lb) x CF (2.47E-8 A/cm2) x Initial Fraction of ai
Retained on the Foliage (standard assumptions of 5% for turf)]
4 TC (cm2/hr) = transfer coefficients and associated activities from ExpoSAC Policy Memo #003.1 "Agricultural Transfer Coefficients",
8/17/2000.
5 MOE = MOE on the corresponding DAT. MOE = NOAEL / Daily Dose.
Daily Dose = [(TTR x TC x 100% Dermal absorption x 8-hr Exposure Time)] / [(CF: 1000 ug/mg) x (70-kg Body Weight)]
Short-/intermediate-term NOAEL = 159 mg/kg/day. The LOC is 100.
4. Residential Exposure: Thiencarbazone-methyl has uses proposed for application to
residential turfgrass and recreational sites. The labels do not prohibit homeowners
from using these products; therefore, residential handlers may receive short-term
dermal and inhalation exposure to thiencarbazone methyl when mixing, loading and
applying the formulations; therefore, short-term non-occupational handler exposure
was evaluated. The Total MOEs for residential handlers are above the LOC of 100,
and are not of concern. Summaries of residential handler exposure and risk estimates
associated with the proposed uses of thiencarbazone-methyl are presented in Table 9
below:
Table 9 Handler Exposure and Risk Estimates for Residential Lawn Applicators
Handler Scenario
(1) Mix/load and spot application of liquid
formulation (low-pressure hand sprayer)
(2) Mix/load and broadcast application of
liquid formulation (garden hose-end sprayer)
Application
Rate1
(Ib ai/A)
0.027
0.027
Area
Treated2
(acres/day)
0.023
(1,000ft2)
0.50
Unit
Exposure 3
(mg/lb ai)
Dermal:
100
Inhalation:
0.030
Dermal:
11
Inhalation:
0.017
Short-Term
Daily Dose 4
(mg/kg/day)
Dermal:
0.00089
Inhalation:
2.6e-7
Dermal:
0.0021
Inhalation:
0.0000033
Total
MOE5
179,000
76,000
1 Application rate is based on maximum values found in proposed labels
2 Area treated is based on the area that can be reasonably treated in a single day based on the application method (standard EPA/OPP/HED
18
-------
values).
3 Dermal unit exposure values represent short pants and short-sleeved shirt; inhalation values represent no respirator. Values for low-pressure
handwand are reported in the PHED Surrogate Exposure Guide dated August 1998, and those for hose-end sprayer were obtained from the
ORETF data.
4 Daily Absorbed Dose (mg/kg/day) = ([unit exposure * 100 absorption] * Application rate * Area treated) / 70 kg;
where dermal absorption is 100% and inhalation absorption is assumed to be 100%.
5 Short-Term Total MOE = NOAEL (159 mg/kg/day) / Total Daily Absorbed Dose (dermal + inhalation). The LOC is 100.
Residential postapplication exposure via the inhalation route is expected to be negligible;
however, dermal exposure is likely for adults and children entering treated lawns.
Toddlers may also experience exposure via incidental non-dietary ingestion (i.e., hand-to-
mouth, object-to-mouth (turfgrass), and soil ingestion) during postapplication activities
on treated turf. Summaries of residential postapplication risks associated with the
proposed uses of thiencarbazone-methyl are presented in Tables lOa, lOb, lOc and lOd
below:
Table lOa Postapplication Dermal Exposure and Risk from Treated Lawns
Subgroup
Exposed
Adults
Children
Application
Rate
(Ib ai/A)
0.027
Post-
application
day (t)
0
Fraction of
ai
Transferable
from the
Foliage
0.05
Turf
Transferable
Residue 1
(ug/cm2)
0.015
Dermal
Transfer
Coefficient
(cm2/hr)
14,500
5,200
Body
Weight
(kg)
70
15
Daily
Dermal
Dose2
(mg/kg/day)
0.00621
0.01040
Dermal
MOE3
Short-/
-term
26,000
15,000
Table lOb Postapplication Oral Hand-to-Mouth Exposure and Risk for Children from Treated Lawns
Application
Rate
(Ib ai/A)
0.027
Post-
application
day (t)
0
Fraction of
ai
Transferable
from the
Foliage
0.05
Turf
Transferable
Residue 1
(ug/cm2)
0.015
Hand
Surface
Area
(cm2/event)
20
Saliva
Extraction
Factor
50%
Frequency
(events/
hr)
20
Body
Weight
(kg)
15
Daily Dose2
(mg/kg/day)
0.00040
Oral
MOE3
Short-
term
394,000
Table lOc Postapplication Oral Object-to-Mouth (Turfgrass) Exposure and Risk for Children from Treated Lawns
Application
Rate
(Ib ai/A)
0.027
Post-
application
day
(t)
0
Fraction of
ai
Transferable
from the
Foliage
0.20
Grass/Object
Residue 1
(ug/cm2)
0.06
Ingestion
Rate
(cm2/day)
25
Body
Weight
(kg)
15
Daily Dose2
(mg/kg/day)
0.00010
Oral
MOE3
Short-
term
1,580,000
19
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Table lOd Postapplication Incidental Soil Ingestion Exposure and Risk for Children from Treated Lawns
Application
Rate
(Ib ai/A)
0.027
Fraction of ai
Retained in
the Soil
1
Soil
Residue 1
(M«/g)
0.2
Ingestion
Rate
(mg/day)
100
Body
Weight
(kg)
15
Daily Dose2
(mg/kg/day)
0.0000014
Oral MOE3
Short-term
118,000,000
Spray drift is always a potential source of exposure to residents nearby to spraying
operations. This is particularly the case with aerial application, but, to a lesser extent,
could also be a potential source of exposure from the ground application method
employed for thiencarbazone-methyl. However, thiencarbazone-methyl is directly
applied to residential turf and does not result in exposures of concern. It is unlikely that
the potential for risk of exposure to spray drift from the agricultural uses would be higher
than that estimated for contact with treated turf. Recreational exposures to turf (including
playing golf) are expected to be similar to, or in many cases less than, those evaluated for
residential postapplication exposure and risk; therefore, a separate recreational exposure
assessment was not needed.
V. ENVIRONMENTAL CHARACTERIZATION
A. Environmental Fate Characterization
Thiencarbazone-methyl is not expected to persist in aerobic soil environments, aerobic
aquatic or anaerobic aquatic environments, but may persist in anaerobic soil conditions.
Thiencarbazone-methyl is stable to both aqueous and soil photolysis and degrades slowly
via hydrolysis at environmentally relevant pHs. Under aerobic aquatic conditions
thiencarbazone-methyl will degrade moderately fast. Aerobic soil metabolism and
anaerobic aquatic metabolism are the primary routes of degradation for thiencarbazone-
methyl with half-lives ranging from 3.2 to 55 days. Thiencarbazone-methyl is not
expected to volatize, with a reported vapor pressure of 8.8 x 10"14 Pa at 20°C. According
to the Food and Agriculture Organization (FAO) classification scheme, thiencarbazone-
methyl is 'mobile' to 'moderately mobile' based on adsorption K0c values in all soils
ranging from 59.9 to 236. Thiencarbazone-methyl weakly sorbs to soil; however, the
compound's sorption correlates with organic matter. Spray drift, runoff and leaching
represent potential mechanisms of transport of thiencarbazone-methyl to aquatic and
terrestrial habitats. To address these concerns, label language will be required in the form
of surface and ground water advisories that stress the potential of runoff after treatment,
describe conditions that may promote leaching to groundwater, and suggest practices that
may reduce contamination of water.
B. Potential Risks to Non-Target Plants
As would be expected with any herbicide, Agency levels of concern were exceeded for
non-target terrestrial and aquatic vascular plants. The results of this risk assessment
indicate that the proposed uses of thiencarbazone-methyl have the potential for direct
adverse effects to non-listed aquatic plants from use of thiencarbazone-methyl on
20
-------
ornamentals and on corn and potential for risk to listed aquatic plants from all uses of
thiencarbazone-methyl. There is also potential risk of effects to non-listed and listed
terrestrial plants from exposures to thiencarbazone-methyl resulting from all uses.
The Agency strategy to mitigate these risks involve label language that is intended to
keep the pesticide on the intended treatment area, and therefore reduce the potential for
exposure to non-target plants. For example, spray drift management language will be
required on the labeling, which advises users of applicator responsibilities and offers
specific techniques to reduce the possibility of spray drift. In addition, the use of buffer
strips will be discussed in the surface water advisory language, which may further reduce
possible exposure to non-target plants.
C. Potential Risks to Non-Target Animals
Thiencarbazone-methyl is classified as practically non-toxic to fish, aquatic invertebrates,
birds, terrestrial mammals and terrestrial invertebrates on an acute basis, and therefore
RQ values were not calculated for acute exposures. For chronic risks to fish, aquatic-
phase amphibians, aquatic invertebrates, birds, mammals, terrestrial-phase amphibians
and reptiles inhabiting terrestrial habitats, resulting RQs do not exceed the chronic risk
LOG (RQ>1.0) for any proposed use of thiencarbazone-methyl. Although direct effects
to animals are not expected, potential effects to plants from the proposed uses of
thiencarbazone-methyl cannot be precluded and could indirectly affect animals through
loss of forage and habitat.
VI. Regulatory Decision
A. Conditional Registration: A conditional registration is issued for thiencarbazone-
methyl for control of certain broadleaf weeds in corn (field, sweet, pop) and wheat, and
in turf and ornamentals in residential settings.
1. Conditional Data (Confirmatory)
Guideline 830.1700: Submission of a 5-batch analysis reflecting commercial
scale production
Guideline 830.6317 Submission of a storage stability study conducted for a
minimum of one year at ambient warehouse conditions
Guideline 860.1380: Submission of additional storage stability data for the wheat
crop field trial study
Guideline 860.1650: Submission of analytical reference standards for
thiencarbazone-methyl and its metabolites BYH 18636-MMT-glucoside (M22),
and BYH 18636-MMT (M21) and labeled internal standards to the EPA National
Pesticide Standards Repository
21
-------
Guideline 870.7800: Submission of a immunotoxicity study, a new data
requirement under 40 CFR Part 158 as a part of the data requirements for
registration of a pesticide (food and non-food uses). The immunotoxicity study
prescribes functional immunotoxicity testing and is designed to evaluate the
potential of a repeated chemical exposure to produce adverse effects (i.e.,
suppression) on the immune system. Immunotoxicity studies provide critical
scientific information needed to characterize potential hazard to the human
population on the immune system from pesticide exposure. If the immunotoxicity
study shows that the test material poses either a greater or a diminished risk than
that given in the interim decision's conclusion, the risk assessments for the test
material may need to be revised to reflect the magnitude of potential risk derived
from the new data.
Guideline 835.6100: The Terrestrial Field Dissipation guideline is currently
classified as supplemental-upgradable pending review of recently submitted
additional soil storage stability data
Submission of the Analytical Method For The Determination of Residues of
BYH18636 And Its Metabolites BYH18636-carboxylic acid, BYH18636-
sulfonamide, BYH18636 sulfonamide-carboxylic acid, BYH18636-MMT, and
BYH18636-triazolinone carboxamide In Soil and Sediment Using LC/MS/MS
using an additional transition ion
Submission of the Independent Laboratory Validation of Method GS-004-W06-01
for the Determination of BYH18636 and Its Metabolites BYH18636-carboxylic
acid, BYH18636-sulfonamide, BYH18636-sulfonamide carboxylic acid,
BYH18636-MMT and BYH18636-dicarboxy sulfonamide in Water Using LC-
MS/MS
Submission of a copy of Analytical Method AM003506MP1 and samples to
EPA's Analytical Chemistry Laboratory for validation of the PAI
2. Public Interest Finding: A conditional registration under FIFRA Section 3(c)(7)(C)
may be granted if EPA determines that use of the pesticide during such period will
not cause any unreasonable adverse effect on the environment, and that use of the
pesticide is in the public interest.
B. TOLERANCES
Tolerance Levels: Tolerances are established for residues of thiencarbazone-methyl
per se, in or on corn, field, forage at 0.04 ppm; corn, field, grain at 0.01 ppm; corn,
pop, grain at 0.01 ppm; corn, field, stover at 0.02 ppm; corn, pop, stover at 0.01 ppm;
corn, sweet, kernel plus cob with husks removed at 0.01 ppm; corn, sweet, forage at
0.05 ppm; corn, sweet, stover at 0.05 ppm; wheat, forage at 0.10 ppm; wheat, grain at
0.01 ppm; wheat, hay at 0.01 ppm; and wheat, straw at 0.01 ppm.
22
-------
Tolerances are established for combined residues of thiencarbazone-methyl and BYH
18636-MMT [5-methoxy-4-methyl-2,4-dihydro-3H-l,2,4-triazol-3-one], calculated
as thiencarbazone-methyl in or on cattle, meat at 0.02 ppm; cattle, meat byproducts at
0.02 ppm; goat, meat byproducts at 0.02 ppm; goat, meat at 0.02 ppm; horse, meat
byproducts at 0.02 ppm; horse, meat at 0.02 ppm; milk at 0.02 ppm; sheep, meat at
0.02 ppm; and sheep, meat byproducts at 0.02 ppm.
Tolerances are established for for indirect or inadvertent combined residues of
thiencarbazone-methyl, and BYH 18636-MMT-glucoside [2-hexopyranosyl-5-
methoxy-4-methyl-2,4-dihydro-3H-l,2,4-triazol-3-one], calculated as
thiencarbazone-methyl in or on soybean, forage at 0.04 ppm; and soybean, hay at
0.15 ppm.
International MRLs: EPA established tolerances are harmonized with those being
established in Canada and those being recommended by the United Kingdom for
establishment in the European Union, except for EPA specific tolerances on livestock
commodities, livestock feedstuffs, and soybeans (as a rotational crop).
C. REQUIRED ENVIRONMENTAL LABEL STATEMENTS: End use products
containing thiencarbazone-methyl as an active ingredient will be required to add the
following protective language on the product labeling:
1. Environmental Hazards: "For terrestrial uses: Do not apply directly to water, or to
areas where surface water is present or to intertidal areas below the mean high tide
mark. Do not contaminate water when disposing of equipment wash water or rinsate.
2. Ground Water Advisory: "This chemical has properties and characteristics
associated with chemicals detected in ground water. This chemical may leach into
ground water if used in areas where soils are permeable, particularly where the water
table is shallow."
3. Surface Water Advisory:
a. For Agricultural Labels: "This product may impact surface water
quality due to runoff of rain water. This is especially true for poorly
draining soils and soils with shallow ground water. This product is
classified as having "high potential for reaching surface water via
runoff, according to the pesticide's "mean" soil partition coefficient
(Kd) for several days after application. A level, well-maintained
vegetative buffer strip between areas to which this product is applied
and surface water features such as ponds, streams, and springs will
reduce the potential loading of thiencarbazone-methyl from runoff
water and sediment. Runoff of this product will be reduced by avoiding
applications when rainfall is forecasted to occur within 48 hours."
23
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b. For Residential Labels: "This product may impact surface water quality
due to runoff of rain water. This is especially true for poorly draining
soils and soils with shallow ground water. This product is classified as
having "high potential for reaching surface water via runoff, according
to the pesticide's "mean" soil partition coefficient (Kd) for several days
after application. Avoid accidental or intentional application of this
product to ditches, swales, drainage ways or impervious surfaces such
as driveways. Runoff of this product to surface water will be reduced
by avoiding applications when rainfall is forecasted to occur within 48
hours."
4. Spray Drift Management
Spray drift is always a potential source of exposure to residents nearby to spraying
operations. This is particularly the case with aerial application, but, to a lesser extent,
could also be a potential source of exposure from the ground application method
employed for thiencarbazone-methyl. The Agency has been working with the Spray
Drift Task Force, EPA Regional Offices and State Lead Agencies for pesticide
regulation and other parties to develop the best spray drift management practices.
The Agency is now requiring interim mitigation measures for aerial applications that
must be placed on product labels/labeling. The Agency has completed its evaluation
of the new data base submitted by the Spray Drift Task Force, a membership of U.S.
pesticide registrants, and is developing a policy on how to appropriately apply the
data and the AgDRIFT computer model to its risk assessments for pesticides applied
by air, orchard airblast and ground hydraulic methods. After the policy is in place,
the Agency may impose further refinements in spray drift management practices to
reduce off-target drift and risks associated with aerial as well as other application
types where appropriate. Thiencarbazone-methyl may be directly applied to
residential turf, but does not result in exposures of concern. It is unlikely that the
potential for risk of exposure to spray drift from the agricultural uses would be higher
than that estimated for contact with treated turf.
Contact Person at EPA
Jim Tompkins
Product Manager 25
Herbicide Branch
Registration Division (7505P)
Office of Pesticide Programs
Environmental Protection Agency
Aerial Rios Building
1200 Pennsylvania Ave., NW
Washington, DC 20460
DISCLAIMER: The information presented in this Pesticide Fact Sheet is for informational purposes only
and may not be used to fulfill data requirements for pesticide registration and reregistration.
24
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Bibliography
61-1 Chemical Identity
MRID
Citation Reference
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M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
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47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
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61-2 Description of Beginning Materials and Manufacturing Process
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
61-3 Discussion of Formation of Impurities
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
25
-------
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
62-1 Preliminary Analysis
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
62-2 Certification of limits
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
62-3 Analytical Method
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
26
-------
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-2 Color
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-3 Physical State
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-4 Odor
27
-------
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-5 Melting Point
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-6 Boiling Point
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-7 Density
MRID Citation Reference
28
-------
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-8 Solubility
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-9 Vapor Pressure
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-10 Dissociation Constant
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
29
-------
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-11 Oct/Water partition Coef.
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-12 pH
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-13 Stability
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
30
-------
63-14 Oxidizing/Reducting Action
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-15 Flammability
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-16 Explodability
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
63-17 Storage stability
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
-------
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-18 Viscosity
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-19 Miscibility
MRID
Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-20 Corrosion characteristics
32
-------
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
63-21 Dielectric breakdown voltage
MRID Citation Reference
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
72-2 Acute Toxicity to Freshwater Invertebrates
MRID Citation Reference
47069903 Banman, C.; Lam, C. (2005) Acute Toxicity of BYH 18636 Technical to the
Daphnia magna Under Static Conditions. Project Number: EBGSM007.
Unpublished study prepared by Bayer Corp. 34 p.
123-1 Seed germination/seedling emergence and vegitative vigor
MRID Citation Reference
47070227 Pallet, K.; Nguyen, D.; Gosch, H.; et. al. (2006) BYH 18636 + AE0001789 SC
450 Effects on Eleven Species of Non-Target Terrestrial Plants: Seedling
Emergence and Seedling Growth Test (Tier 2). Project Number: SE06/001,
33
-------
EBGSM019, M/281379/01/2. Unpublished study prepared by Bayer
Cropscience Gmbh. 264 p.
47114002 Pallett, K.; Nguyen, D.; Gosch, H. (2006) BYH 18636 + AE 0001789 + IFT SC
465: Effects on Eleven Species of Non-Target Terrestrial Plants: Vegetative
Vigour Test (Tier 2). Project Number: VV/05/064, EBGSP025. Unpublished
study prepared by Bayer Cropscience Gmbh. 211 p.
47114003 Pallett, K.; Gosch, H.; Nguyen, D.; et al. (2006) BYH 18636 + (Inert Ingredient)
+ IFT SC 465: Effects on Eleven Species of Non-Target Terrestrial Plants:
Seeding Emergence and Seedling Growth Test (Tier 2). Project Number:
SE/05/063, EBGSP026. Unpublished study prepared by Bayer Cropscience
Gmbh. 281 p.
47114032 Gosch, H.; Bach, F.; Nguyen, D. (2007) Isoxaflutole + Cyprosulfamide SC 240
+ 240 g/L Effects on Eleven Species of Non-Target Terrestrial Plants: Seedling
Emergence and Seedling Growth Test (Tier 2). Project Number: SE/06/033,
EBUBP062, M/283723/01/1. Unpublished study prepared by Bayer Ag, Institute
of Product Info. & Residue Anal. 247 p.
161-1 Hydrolysis
MRID Citation Reference
47070001 Sneikus, M. (2005) BYH18636: Hydrolytic Degradation. Project Number:
Ml 111344/5, M/259661/02/2, MEF/04/183. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 146 p.
161-3 Photodegradation-soil
MRID Citation Reference
47070003 Stupp, H. (2005) BYH18636: Phototransformation on Soil. Project Number:
Ml 131370/6, M/259443/01/2, MEF/04/561. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 97 p.
162-1 Aerobic soil metabolism
MRID Citation Reference
47070002 Sneikus, J. (2005) BYH 18636: Phototransformation in Water. Project Number:
Ml 121383/9, M/244065/02/2, MEF/04/381. Unpublished study prepared by
34
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Bayer Ag, Institute of Product Info. & Residue Anal. 82 p.
47070004 Fliege, R. (2005) [Dihydrotriazole-3-Carbon] and [Thiophene-4-Carbon] BYH
18636: Aerobic Soil Metabolism in One US Soil: Project Number: M1251357/4,
M/263213/01/2, MEF/05/224. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal. 119 p.
47070005 Nicolaus, B; Fliege, R. (2006) [Dihydrotriazole-3-(14-Carbon)] and [Thiophene-
4-(14-Carbon)] BYH 18636: Aerobic Soil Metabolism in Four Soils. Project
Number: M1251264/1, M/276687/01/2, MEF/05/532. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 168 p.
47070007 Heinemann, O. (2006) BYH18636-Trizolinone Carboxamide: Aerobic Soil
Degradation in 3 EU Soils. Project Number: M1251514/9, M/276814/01/2,
MEF/05/519. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 88 p.
162-2 Anaerobic soil metabolism
MRID Citation Reference
47070008 Fliege, R. (2007) [Dihydrotriazole-3-(14-Carbon)] and [Thiophene-4-(14-
Carbon)] BYH 18636: Anaerobic Soil Metabolism. Project Number:
M1261402/6, MEF/05/490, M/274584/01/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 125 p.
162-3 Anaerobic aquatic metab.
MRID Citation Reference
47070009 Arthur, E.; Shepherd, 1; Ripperger, R.; et. al. (2007) [Dihydrotriazole-3-(14-
Carbon) and Thiophene-4-(14-Carbon)] BYH18636: Anaerobic Aquatic
Metabolism. Project Number: MEGSM012, M/285668/01/1. Unpublished study
prepared by Bayer Corp. 118 p.
162-4 Aerobic aquatic metab.
MRID Citation Reference
47070010 Henk, F.; Haas, M. (2005) BYH18636: Aerobic Aquatic Metabolism. Project
Number: M1511345/0, MEGSM011, M/262178/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 139 p.
35
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163-1 Leach/adsorp/desorption
MRID
Citation Reference
47070011 Fliege, R. (2003) Adsorption/Desorption of BYH 18636 on Five Soils. Project
Number: M1311278/3, MO/03/013980, M/l 10732/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 85 p.
47070012 Henk, F.; Haas, M. (2004) GSE12201: Adsorption/Desorption on Five Soils: (Fs
500 Sorghum Seed Protectant). Project Number: M1311337/9, M/081509/01/2,
MEF/027/04. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 94 p.
47070013 Stupp, H. (2004) GSE28226: Adsorption/Desorption in Five Soils. Project
Number: M1311343/6, M/086868/01/2, MEF/191/04. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 84 p.
47070014 Fliege, R. (2004) GSE 18448: Adsorption/Desorption on Five Soils. Project
Number: M1311335/7, M/082278/01/2, MO/04/007461. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 104 p.
47070015 Simmonds, M.; Early, E. (2005) [14-Carbon]-BYH18636-[Inert Ingredient]-
Carboxylic Acid: Adsorption to and Desorption From Five Soils. Project
Number: CX/04/069, M/263558/01/2. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal. 96 p.
164-1 Terrestrial field dissipation
MRID
Citation Reference
47070016 Wyatt, D. (2007) Terrestrial Field Dissipation of BYH18636 in California Soil,
2005. Project Number: MEGSM013, M/285682/01/1. Unpublished study
prepared by Bayer Corp., Agvise Inc. and Research for Hire. 246 p.
47070017 Wyatt, D. (2007) Terrestrial Field Dissipation of BYH18636 in Nebraska Soil,
2005. Project Number: MEGSP002, M/285681/01/1, GS/003/S06/01.
Unpublished study prepared by Bayer Corp., Agvise Inc. and Midwest
Research, Inc. 236 p.
47070018 Wyatt, D. (2007) Terrestrial Field Dissipation of BYH18636 in Ontario, Canada
Soil, 2005. Project Number: MEGSP003, M/285678/01/1. Unpublished study
prepared by Bayer Corp., Agvise Inc. and Bayer CropScience Canada. 238 p.
47070019 Wyatt, D. (2007) Terrestrial Field Dissipation of BYH18636 in Illinois Soil,
2005. Project Number: MEGSP004, M/285673/01/1, GS/003/S06/01.
Unpublished study prepared by Bayer Corp., Agvise Inc. and Alvey Lab & Agr
36
-------
Research Services. 233 p.
810.2700 Products for treating water systems
MRID
Citation Reference
47070040 Heinemann, O. (2004) BYH18636: Determination of the Quantum Yield and
Assessment of the Environmental Half-life of the Direct Photodegradation in
Water. Project Number: MEF/04/200, M1431325/9, M/093045/02/2.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 24 p.
830.1550 Product Identity and composition
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1600 Description of materials used to produce the product
MRID
Citation Reference
37
-------
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1620 Description of production process
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1650 Description of formulation process
38
-------
MRID
Citation Reference
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1670 Discussion of formation of impurities
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
39
-------
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1700 Preliminary analysis
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1750 Certified limits
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
40
-------
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.1800 Enforcement analytical method
MRID
Citation Reference
47069901 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2558, VB1/AM003506MP1, ANR/05307. Unpublished
study prepared by Bayer Corp. 341 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.6302 Color
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
41
-------
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.6303 Physical state
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
42
-------
830.6304 Odor
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.6313
ions
Stability to sunlight, normal and elevated temperatures, metals, and metal
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.6314 Oxidizing or reducing action
MRID
Citation Reference
43
-------
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47492701 Smeykal, H. (2008) Thiencarbazone-Methyl (BYH 18636): Oxidizing
Properties: Final Report. Project Number: 20080269/01. Unpublished study
prepared by Siemens AG. 15 p.
830.6315 Flammability
MRID
Citation Reference
47069902
47070222
47070301
47070309
47114001
Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.6316 Explodability
MRID
Citation Reference
47069902
Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
44
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Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.6317 Storage stability of product
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
47487001 Tebbe, R. (2008) Storage Stability and Corrosion Characteristics of (Inert
Ingredient) + Thiencarbazone-Methyl WG 42+21. Project Number: 06SG002,
06MG006, 201765. Unpublished study prepared by Bayer CropScience. 28 p.
47487102 Tebbe, R. (2008) Storage Stability and Corrosion Characteristics of
Thiencarbazone-methyl + (Inert Ingredient) 10 + 60 g/1. Project Number:
06SG028, 06MG026, M/297478/01/1. Unpublished study prepared by Bayer
CropScience. 29 p.
830.6319 Miscibility
45
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MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.6320 Corrosion characteristics
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
47487001 Tebbe, R. (2008) Storage Stability and Corrosion Characteristics of (Inert
Ingredient) + Thiencarbazone-Methyl WG 42+21. Project Number: 06SG002,
06MG006, 201765. Unpublished study prepared by Bayer CropScience. 28 p.
47487102 Tebbe, R. (2008) Storage Stability and Corrosion Characteristics of
Thiencarbazone-methyl + (Inert Ingredient) 10 + 60 g/1. Project Number:
46
-------
06SG028, 06MG026, M/297478/01/1. Unpublished study prepared by Bayer
CropScience. 29 p.
830.6321 Dielectric breakdown voltage
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.7000 pH of water solutions or suspensions
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
47
-------
830.7050 UV/Visible absorption
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.7100 Viscosity
MRID
Citation Reference
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.7200 Melting point/melting range
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
48
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CropScience LP. 282 p.
830.7220 Boiling point/boiling range
MRID
Citation Reference
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
830.7300 Density/relative density
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070222 Mitchell, H. (2007) Product Chemistry of SC 450 Herbicide. Project Number:
FOR0852, BR2555, ANR/02207. Unpublished study prepared by Bayer Corp.
160 p.
47070301 Long, D. (2007) Product Chemistry of WG 63 Herbicide. Project Number:
BR/2557. Unpublished study prepared by Bayer Corp. 144 p.
47070309 Mitchell, H. (2007) Product Chemistry of SC 547 Herbicide. Project Number:
BR/2553. Unpublished study prepared by Bayer Corp. 237 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
47114022 Mitchell, H. (2007) Product Chemistry of SC 480 Herbicide. Project Number:
BR/2556, FOR0873/PC/01, FTA06/019. Unpublished study prepared by Bayer
Corp. 249 p.
830.7370 Dissociation constant in water
MRID
Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
49
-------
830.7520 Particle size, fiber length, and diameter distribution
MRID Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
830.7560 Partition coefficient (n-octanol/water), generator column method
MRID Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
830.7840 Water solubility: Column elution method, shake flask method
MRID Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
830.7950 Vapor pressure
MRID Citation Reference
47069902 Fontaine, L. (2007) Product Chemistry of Thiencarbazone-Methyl Technical.
Project Number: BR2559, PA05/089, 20050633/01. Unpublished study prepared
by Bayer Corp. 325 p.
47070243 Mitchell, H. (2007) Product Chemistry of OD 70 Herbicide. Project Number:
M/286092/01, BR/2552. Unpublished study prepared by Bayer CropScience LP.
172 p.
47114001 Mitchell, H. (2007) Product Chemistry of SC 465 Herbicide. Project Number:
BR/2554, ANR/01807, RM/G01437. Unpublished study prepared by Bayer
CropScience LP. 282 p.
835.1230 Sediment and soil absorption/desorption for parent and degradates
50
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MRID
Citation Reference
47070042 Koenig, H; Fliege, R. (2006) BHY 18636-Triazolinone-Carboxamide (AE
1430601): Estimation of the Adsorption Coefficient (KOC) on Soil Using High
Performance Liquid Chromatography. Project Number: MEF/05/417,
M1381518/7, M/268082/01/2. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal. 39 p.
835.4300 Aerobic aquatic metabolism
MRID
Citation Reference
47070041
Sneikus, J. (2006) BYH18636-MMT: Aerobic Aquatic Degradation. Project
Number: MEF/06/500, M1511573/3, M/281546/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 79 p.
850.1010 Aquatic invertebrate acute toxicity, test, freshwater daphnids
MRID
Citation Reference
47069903 Banman, C.; Lam, C. (2005) Acute Toxicity of BYH 18636 Technical to the
Daphnia magna Under Static Conditions. Project Number: EBGSM007.
Unpublished study prepared by Bayer Corp. 34 p.
47069904 Bruns, E. (2006) BYH 18636-Sulfonamide (tech): Comparative Toxicity of Two
Different Batches of the Test-Item to the Waterflea Daphnia magna in a Static
Laboratory Test System. Project Number: EBGSP081, M/271240/01/2.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 7 p.
47069905 Bruns, E. (2007) Acute Toxicity of BYH 18636-sulfonamide to the Waterflea
Daphnia magna in a Static Laboratory Test System: Limit-Test. Project Number:
E/320/3195/3, EBGSP087, 00991/MOO1. Unpublished study prepared by Bayer
Ag, Institute of Product Info. & Residue Anal. 42 p.
47069945 Banman, C.; Lam, C. (2007) Acute Toxicity of BYH 18636 [Inert Ingredient] to
the Daphnia magna Under Static Conditions. Project Number: EBGSP002/1,
M/261931/02/1. Unpublished study prepared by Bayer Corp. 37 p.
47070225 Bruns, E. (2007) Acute Toxicity of BYH 18636 and AE 0001789 SC 450 to the
Waterflea Daphnia magna in a Static Laboratory Test System. Project Number:
E/320/3081/7, EBGSP051, MR/06/106. Unpublished study prepared by Bayer
Ag, Institute of Product Info. & Residue Anal. 56 p.
51
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47114011 Grade, R.; Wydra, V. (2006) Acute Toxicity of Thiencarbazone-Methyl +
Isoxaflutole + (Inert Ingredient) SC (90 +225 + 150 g/L) Formulation to
Daphnia magna in a 48-Hour Immobilization Test: Final Report. Project
Number: 30172220. Unpublished study prepared by Institut fuer Biologische
Analytik und Consulting IBACON. 58 p.
47114029 Burns, E. (2007) Acute Toxicity of [inert ingredient] & Isoxaflutole SC 240 +
240 to the Waterflea Daphnia magna in a Static Laboratory Test System-Limit
Test. Project Number: E/320/3163/8, EBUBP106, 01001. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 48 p.
850.1025 Oyster acute toxicity test (shell deposition)
MRID
Citation Reference
47069907
Cafarella, M. (2006) BYH 18636 Technical - Acute Toxicity to Eastern Oyster
(Crassostrea virginica) Under Flow-Through Conditions. Project Number:
13798/6188, EBGSP010, M/281935/01/1. Unpublished study prepared by
Springborn Smithers Laboratories. 56 p.
850.1035 Mysid acute toxicity test
MRID
Citation Reference
47069906
Putt, A. (2006) BYH 18636 Technical - Acute Toxicity to Mysids
(Americamysis bahia) Under Flow-Through Conditions. Project Number:
13798/6189, EBGSP011. Unpublished study prepared by Springborn Smithers
Laboratories. 52 p.
850.1075 Fish acute toxicity test, freshwater and marine
MRID
Citation Reference
47069908
47069909
Banman, C.; Lam, C. (2005) Acute Toxicity of BYH 18636 Technical to the
Sheepshead Minnow (Cyprinodon variegatus) Under Static Conditions. Project
Number: EBGSM011, MO/05/008919. Unpublished study prepared by Bayer
Corp. 34 p.
Banman, C.; Lam, C. (2005) Acute Toxicity of BYH 18636 Technical to the
Bluegill (Lepomis macrochirus) Under Static Conditions. Project Number:
EBGSM013, M/257680/01/1. Unpublished study prepared by Bayer Corp. 37 p.
52
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47069910 Banman, C.; Lam, C. (2005) Acute Toxicity of BYH 18636 Technical to the
Rainbow Trout (Oncorhynchus mykiss) Under Static Conditions. Project
Number: EBGSM014, MO/05/009287. Unpublished study prepared by Bayer
Corp. 37 p.
47069944 Banman, C.; Roberts, I; Lam, C. (2007) Acute Toxicity of BYH 18636 [Inert
Ingredient] to the Rainbow Trout (Oncorhynchus mykiss) Under Static
Conditions. Project Number: EBGSP001/1, M/262252/02/01. Unpublished
study prepared by Bayer Corp. 38 p.
47070223 Nieden, D. (2006) Acute Toxicity of BYH 18636 & AE 0001789 SC 450 to Fish
(Oncorhynchus mykiss) under Static Conditions. Project Number: EBGSP049,
E/320/3097/9, MR/06/106. Unpublished study prepared by Bayer Ag, Institute
of Product Info. & Residue Anal. 57 p.
47114012 Grade, R.; Wydra, V. (2006) Acute Toxicity of Thiencarbazone-Methyl +
Isoxzflutole + (Inert Ingredient) SC (90 + 225 + 150 g/L) Formulation to
Rainbow Trout (Oncorhynchus mykiss) in a 96-Hour Static Test: Final Report.
Project Number: 30173230, M/278096/01/1. Unpublished study prepared by
Institut fuer Biologische Analytik und Consulting IBACON. 56 p.
47114030 Nieden, D. (2007) Acute Toxicity of Cyprosulfamide & Isoxaflutole SC
240+240 to Fish (Oncorhynchus mykiss) Under Static Conditions. Project
Number: EBUBP107, E/280/3207/2, 01001. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Analysis. 56 p.
850.1300 Daphnid chronic toxicity test
MRID
Citation Reference
47069911 Kern, M.; Lam, C. (2007) Chronic Toxicity of BYH 18636 Technical to the
Daphnia magna Under Static-renewal Conditions. Project Number: EBGSM008,
M/264057/02/1. Unpublished study prepared by Bayer Corp. 58 p.
850.1350 Mysid chronic toxicity test
MRID
Citation Reference
47069912 Putt, A. (2006) BYH 18636 Technical - Life-Cycle Toxicity Test with Mysids
(Americamysis bahia). Project Number: 13798/6190, EBGSP004,
M/281198/01/2. Unpublished study prepared by Springborn Smithers
Laboratories. 93 p.
850.1400 Fish early-life stage toxicity test
53
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MRID
Citation Reference
47069913 Kern, M.; Roberts, J.; Lam, C. (2006) Early Life Stage Toxicity of BYH 18636
Technical to the Fathead Minnow (Pimephales promelas) Under Flow-Through
Conditions. Project Number: EBGSP013, M/264063/01/1. Unpublished study
prepared by Bayer Corp. 77 p.
850.2100 Avian acute oral toxicity test
MRID
Citation Reference
47069914
Barfknecht, R. (2005) Acute Oral Toxicity for Bobwhite quail (Colinus
virginianus) with BYH 18636 a.s. Project Number: E/204/2985/0, BAR/LD075,
M/261212/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 30 p.
850.2200 Avian dietary toxicity test
MRID
Citation Reference
47069915
47069916
Stoughton, T. (2005) Technical BYH 18636: A Substance Dietary LC50 with
Northern Bobwhite. Project Number: EBGSM006, M/278496/01/1.
Unpublished study prepared by Bayer Corp. 52 p.
Stoughton, T. (2006) Technical BYH 18636: A Subacute Dietary LC50 with
Mallards. Project Number: EBGSP009, M/278504/01/1. Unpublished study
prepared by Bayer Corp. 53 p.
850.2300 Avian reproduction test
MRID
Citation Reference
47069917
47069918
Christ, M.; Lam, C. (2007) Effect of BYH 18636 Technical on Mallard
Reproduction. Project Number: EBGSP007, M/285456/01/1. Unpublished study
prepared by Bayer Corp. 111 p.
Christ, M.; Lam, C. (2007) Effect of Technical BYH 18636 on Northern
Bobwhite Reproduction. Project Number: EBGSP008. Unpublished study
prepared by Bayer Corp. 148 p.
850.3020 Honey bee acute contact toxicity
54
-------
MRID
Citation Reference
47069919 Earth, M. (2005) Acute Toxicity of BYH 18636 a.i. tech to the Honeybee Apis
mellifera L. Under Laboratory Conditions: Final Report. Project Number:
05/10/48/030, M/253914/01/2. Unpublished study prepared by Bayer
Cropscience Gmbh. 32 p.
47070231 Earth, M. (2006) Acute Toxicity of BYH 18636 & AE 0001789 SC 225 + 225
to the Honeybee Apis mellifera L. Under Laboratory Conditions: Final Report.
Project Number: 06/10/48/048, M/274661/01/2. Unpublished study prepared by
Bayer Cropscience Gmbh. 30 p.
47114004 Waltersdorfer, A. (2006) Toxicity to the Parasitoid Wasp Aphidius Rhopalosiphi
(DeStaphani-Perez) (Hymenoptera: Braconidae) in the Laboratory BYH 18636
and Isoxaflutole and (Inert Ingredient) SC 90 + 225 + 150g/l. Project Number:
CW05/090. Unpublished study prepared by Bayer Cropscience Gmbh. 28 p.
47114014 Earth, M. (2004) Acute Toxicity of BYH 18636 and Isoxaflutole and (Inert
Ingredient) SC 90 + 225 + 150 to the Honeybee Apis mellifera L. Under
Laboratory Conditions. Project Number: 06/10/48/049. Unpublished study
prepared by Biochem Agrar, Lab fuer Biologische und Chemische. 30 p.
47114023 Waltersdorfer, A. (2006) Toxicity to the Predatory Mite Typhlodromus pyri
Scheuten (Acari, Phytoseiidae) in the Laboratory Isoxaflutole & Cyprosulfamide
SC 240 + 240 g/1. Project Number: CW06/049, M/279415/01/1. Unpublished
study prepared by Bayer Cropscience Gmbh. 33 p.
47114026 Muther-Paul, J. (2006) Assessment of Side Effects of Isoxaflutole &
Cyprosulfamide SC 240+240 g/L to the Honey Bee, Apis mellifera L., in the
Laboratory: Final Report. Project Number: 20061213/01/BLEU,
M/278327/01/1. Unpublished study prepared by GAB Biotechnologie Gmbh. 30
P-
850.4100 Terrestrial plant toxicity, Tier 1 (seeding emergence)
MRID
Citation Reference
47070235 Bach, F.; Pallett, K. (2007) Higher Tier Non Target Terrestrial Plants Study on
the Seedling Emergence and Growth of 4 Plants Species Under Semi-Field
Conditions. The Phytotoxic Effects of TCM + CSA SC 225 + 225 G
(Thiencarbazone-Methyl + [Inert Ingredient] + 225 G/L). Project Number:
EBGSP082, HT06/041, M/282887/02/2. Unpublished study prepared by Bayer
Cropscience Gmbh. 158 p.
47114013 Bach, F.; Pallett, K. (2007) Higher Tier Non Target Terrestrial Plant Study on
the Seedling Emergence and Growth of 3 Plant Species Under Semi-Field
55
-------
Conditions: The Phytotoxic Effects of BYH 18636 + Isoxaflutole +(Inert
Ingredient) SC 90 + 225 + 150 ( TCM+IFT+CSA SC 90 + 225 + 150 G). Project
Number: HT06/055, EBGSP083. Unpublished study prepared by Bayer
Cropscience Gmbh. 137 p.
850.4150 Terrestrial plant toxicity, Tier 1 (vegetative vigor)
MRID
Citation Reference
47070233 Bach, F.; Pallett, K. (2006) Higher Tier Non Target Terrestrial Plant Study on
the Vegetative Vigour Test of 3 Plant Species Determined Under Semi-Field
Conditions. The Phytotoxic Effects of BYH 18636 + AE 0001789 SC 225 + 225
(Thiencarbazone-methyl + Cyprosulfamide SC 225 + 225 G, High load). Project
Number: HT06/040, EBGSP054, M/281484/02/2. Unpublished study prepared
by Bayer CropScience Gmbh. 109 p.
850.4225 Seedling emergence, Tier II
MRID
Citation Reference
47114003 Pallett, K.; Gosch, H.; Nguyen, D.; et al. (2006) BYH 18636 + (Inert Ingredient)
+ IFT SC 465: Effects on Eleven Species of Non-Target Terrestrial Plants:
Seeding Emergence and Seedling Growth Test (Tier 2). Project Number:
SE/05/063, EBGSP026. Unpublished study prepared by Bayer Cropscience
Gmbh. 281 p.
47376805 Gosch, H.; Nguyen, D. (2007) BYH 18636 + AE F107892 OD 10 + 60 g/L:
Effects on Ten Species of Non-Target Terrestrial Plants: Seedling Emergence
and Seedling Growth Test (Tier 2). Project Number: SE/07/023, EBGSP094.
Unpublished study prepared by Bayer Cropscience Gmbh. 181 p.
850.4250 Vegetative vigor, Tier II
MRID
Citation Reference
47070228 Pallett, K.; Nguyen, D.; Gosch, H. (2006) BYH18636 + AE 0001789 SC 450
Effects on Eleven Species of Non-Target Terrestrial Plants: Vegetative Vigour
Test (Tier 2). Project Number: VV/06/002, EBGSM020, M/281425/01/2.
Unpublished study prepared by Bayer Cropscience Gmbh. 229 p.
47114002 Pallett, K.; Nguyen, D.; Gosch, H. (2006) BYH 18636 + AE 0001789 + IFT SC
465: Effects on Eleven Species of Non-Target Terrestrial Plants: Vegetative
56
-------
Vigour Test (Tier 2). Project Number: VV/05/064, EBGSP025. Unpublished
study prepared by Bayer Cropscience Gmbh. 211 p.
47114003 Pallett, K.; Gosch, H.; Nguyen, D.; et al. (2006) BYH 18636 + (Inert Ingredient)
+ IFT SC 465: Effects on Eleven Species of Non-Target Terrestrial Plants:
Seeding Emergence and Seedling Growth Test (Tier 2). Project Number:
SE/05/063, EBGSP026. Unpublished study prepared by Bayer Cropscience
Gmbh. 281 p.
47114006 Bach, F.; Pallett, K. (2006) Higher Tier Non Target Terrestrial Plant Study on
the Vegetative Vigour Test of 3 Plant Species Determined Under Semi-Field
Conditions: The Phytotoxic Effects of IFT + TCM + CSA SC 225 + 90 + 225 +
150 G/L. Project Number: HT06/056, EBGSP057, M/281486/01/1. Unpublished
study prepared by Bayer Cropscience Gmbh. 114 p.
47376804 Gosch, H.; Nguyen, D. (2007) BYH 18636 + AE F107892 OD 10 + 60 g/L:
Effects on Ten Species of Non-Target Terrestrial Plants: Vegetative Vigor Test
(Tier 2). Project Number: VV/07/024, EBGSP095, M/291527/01/1.
Unpublished study prepared by Bayer Cropscience Gmbh. 204 p.
850.4400 Aquatic plant toxicity test using Lemna spp. Tiers I and II
MRID
Citation Reference
47069920 Kern, M.; Lam, C. (2006) Toxicity of BYH 18636 Technical to Duckweed
(Lemna gibba G3) Under Static-Renewal Conditions. Project Number:
EBGSM016, M/269681/01/1. Unpublished study prepared by Bayer Corp. 51 p.
47069921 Christ, M.; Lam, C. (2007) Exposure and Recovery with BYH 18636 Technical
to Duckweed (Lemna gibba G3). Project Number: EBGSP070, M/285458/01/1.
Unpublished study prepared by Bayer Corp. 47 p.
47069922 Banman, C.; Lam, C. (2005) Toxicity of BYH 18636 Carboxylic Acid to
Duckweek (Lemna gibba G3) Under Static-Renewal Conditions. Project
Number: EBGSP019, M/258496/01/1. Unpublished study prepared by Bayer
Corp. 50 p.
47069923 Christ, M.; Lam, C. (2006) Toxicity of BYH 18636 Sulfonamide (a Metabolite
of BYH 18636) to Duckweed (Lemna gibba G3) Under Static-Renewal
Conditions. Project Number: EBGSP029, M/284166/01/1. Unpublished study
prepared by Bayer Corp. 44 p.
47069924 Dorgerloh, M. (2006) Lemna gibba G3 Growth Inhibition Test with BYH
18636-Sulfonamide-Carboxylic Acid Under Static Conditions. Project Number:
E/412/3075/2, EBGSP042, M/273657/02/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 59 p.
47069925 Christ, M.; Hoffmann, I; Lam, C. (2007) Toxicity of BYH 18636-Dicarboxy-
57
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Sulfonamide (a Metabolite of BYH 18636) to Duckweed (Lemna gibba G3)
Under Static-Renewal Conditions. Project Number: EBGSP045,
M/283800/01/1. Unpublished study prepared by Bayer Corp. 45 p.
47069932 Christ, M.; Lam, C. (2007) Toxicity of BYH 18636 Technical to the Aquatic
Macrophyte, Myriophyllum spicatum, During a 14-Day Exposure and 14-Day
Recovery Period. Project Number: EGSP077, M/285462/01/1. Unpublished
study prepared by Bayer Corp. 70 p.
47069936 Christ, M.; Lam, C. (2007) Toxicity of BYH 18636 MMT (a Metabolite of BYH
18636) to Duckweed (Lemna gibba G3) Under Static-Renewal Conditions.
Project Number: EBGSP040, M/283972/01/1. Unpublished study prepared by
Bayer Corp. 44 p.
47070224 Dorgerloh, M. (2006) Pseudokirchneriella subcapitata Growth Inhibitor Test
with BYH 18636 and AE 0001789 SC 450. Project Number: E/323/3086/5,
EBGSP050, M/275768/01/2. Unpublished study prepared by Bayer Ag, Institute
of Product Info. & Residue Anal. 67 p.
47070226 Dorgerloh, M. (2007) Lemna gibba G3 Growth Inhibition Test with BYH 18636
+ AE 0001789 SC 225 + 225 Under Static Conditions. Project Number:
EBGSP052, E/412/3096/5, M/275696/02/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 81 p.
47114009 Grade, R. (2006) Toxicity of Thiencarbozone-Methyl + Isoxaflutole + (Inert
Ingredient) SC (90 + 225 + 150 g/L) Formulation to the Aquatic Plant Lemna
gibba in a Growth Inhibition Test: Final Report. Project Number: 30174240,
M/281518/01/1. Unpublished study prepared by Institut fuer Biologische
Analytik und Consulting IBACON. 70 p.
47114027 Dorgerloh, M. (2007) Lemna gibba G3 Growth Inhibition Test with (Inert
Ingredient) & Isoxaflutole SC 240 + 240 Under Static Conditions (spec No.:
102000014305). Project Number: EBUBP101, E/412/3168/5, M/284141/01/1.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 77 p.
47114028 Dorgerloh, M. (2007) Pseudokirchneriella subcapitata Growth Inhibition Test
with Cyprosulfamide & Isoxaflutole SC 480 (240 + 240) G: CSA & IFT SC 480
(240 + 240) G. Project Number: EBUBP104, E/323/3157/4, M/284638/01/1.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 70 p.
850.5400 Algal toxicity, Tiers 1 and II
MRID
Citation Reference
47069926
Christ, M.; Lam, C. (2006) Toxicity of BYH 18636 Technical to the Saltwater
58
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Diatom Skeletonema costatum. Project Number: EBGSM017, M/281203/01/1.
Unpublished study prepared by Bayer Corp. 46 p.
47069927 Kern, M.; Banman, C.; Lam, C. (2005) Toxicity of BYH 18636 Technical to the
Green Alga Pseudokirchneriella subcapitata. Project Number: EBGSM001,
M/256477/01/1. Unpublished study prepared by Bayer Corp. 51 p.
47069928 Kern, M.; Roberts, 1; Lam, C. (2005) Toxicity of BYH 18636 Technical to the
Freshwater Diatom Navicula pelliculosa. Project Number: EBGSM015,
M/257683/01/1. Unpublished study prepared by Bayer Corp. 49 p.
47069929 Kern, M.; Lam, C. (2007) Toxicity of BYH 18636 Technical to the Blue-Green
Algae Anabaena flos-aquae. Project Number: EBGSP012, M/264060/02/2.
Unpublished study prepared by Bayer Corp. 49 p.
47114010 Grade, R.; Wydra, V. (2006) Toxicity of Thiencarbazone-Methyl + Isoxaflute +
(Inert Ingredient) SC (90 + 225 + 150 g/L) Formulation to Pseudokirchneriella
subcapitata in an Algal Growth Inhibition Test: Final Report. Project Number:
30171210, M/278975/01/1. Unpublished study prepared by Institut fuer
Biologische Analytik und Consulting IBACON. 67 p.
860.1000 Background
MRID
Citation Reference
47070104 Brumhard, B.; Auer, S.; Eberhardt, R. (2007) BYH 18636: Dairy Cattle Feeding
Study. Project Number: P673065520, MR/06/095. Unpublished study prepared
by Bayer Ag, Institute of Product Info. & Residue Anal. 207 p.
860.1300 Nature of the residue - plants, livestock
MRID
Citation Reference
47070021 Bongartz, R. (2005) Metabolism of [Dihydrotriazole-3- (14-Carbon)]
BYH18636 in Corn. Project Number: M1731294/7, M/266796/02/2,
MEF/04/182. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 177 p.
47070022 Schmeer, K.; Koester, J. (2006) Metabolism of [Dihydrotriazole-3-(14-Carbon)]
BYH18636 in the Laying Hen. Project Number: M1819158/3, MEF/05/259,
M/279676/03/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 98 p.
47070023 Koester, J. (2006) [Dihydrotriazole-3-(14-Carbon)] BYH 18636: Absorption,
Distribution, Excretion, and Metabolism in the Lactating Goat. Project Number:
59
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M61819151, M/276289/01/2, MEF/05/307. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 195 p.
47070024 Bongartz, R. (2005) Metabolism of [Dihydrotriazole-3-(14-Carbon)] BYH18636
in Corn in Combination with the Safener Isoxadifen-ethyl Following Two Post-
Emergence Applications at Growth Stages V6 and V12. Project Number:
M1731392/6, M/267247/01/2, MEF/05/006. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 85 p.
47070025 Bongartz, R. (2005) Metabolism of [Dihydrotriazole-3-(14-Carbon)] BYH18636
in Corn in Combination with the Safener AE 0001789 as a Pre-Emergence
Application. Project Number: M1731384/7, M/263042/01/2, MEF/05/004.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 68 p.
47070026 Sur, R. (2005) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in Wheat.
Project Number: M1731267/7, M/268145/01/2, MEF/05/042. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 154 p.
47070027 Schmeer, K.; Koester, J. (2006) Metabolism of [Thiophene-4-(14-Carbon)]
BYH18636 in the Laying Hen. Project Number: M1819164/0, M/279414/03/2,
MEF/05/260. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 87 p.
47070028 Schmeer, K.; Koester, J. (2006) [Thiophene-4-(14-Carbon)] BYH 18636:
Absorption, Distribution, Excretion, and Metabolism in the Lactating Goat.
Project Number: M1819162/8, M/278516/01/2, MEF/05/261. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 91 p.
47070029 Bongartz, R. (2006) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Corn in Combination with the Safener Isoxadifen-ethyl Following Two Post-
Emergence Applications at Growth Stages V6 and V12. Project Number:
M1731393/7, M/268530/01/2, MEF/05/005. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 90 p.
47070030 Bongartz, R. (2005) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Corn. Project Number: M1731293/6, M/256647/01/2, MEF/04/181.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 179 p.
47070031 Bongartz, R. (2005) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Corn in Combination with the Safener AE 0001789 as a Pre-Emergence
Application. Project Number: Ml731385/8, M/263405/01/2, MEF/05/003.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 77 p.
47070045 Sur, R. (2005) [Dihydrotriazole-3-(14-Carbon)] BYH18636 in Wheat. Project
Number: MEF/05/041, M/1731269/9, M/267443/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 176 p.
60
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47114034 Meyer, B.; Ripperger, R. (2006) The Metabolism of [Phenyl-UL-(carbon-14)]-
Isoxaflutole in Corn with Post -Emergence Application. Project Number:
MEUBY003, M/268739/01/1. Unpublished study prepared by Bayer Corp. 59 p.
860.1340 Residue analytical method
MRID
Citation Reference
47070032 Schmeer, K. (2007) [Dihydrotriazole-3-(14-Carbon)] BYH18636 and
[Thiophene-4-Carbon] BYH18636: Extraction Efficacy of the Residue
Analytical Method for the Determination of BYH18636 Residues in Animal
Matrices using Aged Radioactive Residues. Project Number: MEF/06/292,
M9991596/8, M/282899/01/2. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal. 53 p.
47070044 Brumhard, B.; Koch, V. (2007) Independent Laboratory Validation of Method
Gs-003-S06-01 For The Determination of BYH18636 and its Metabolites
BYH18636-Carboxylic acid, BYH18636-Sulfonamide, BYH18636-
Sulfonamide-Carboxylic acid, BYH18636-MMT, and BYH18636-Triazlinone
Carboxamide in Soil and Sediment Using LC/MS/MS. Project Number:
MR/06/155, P611060013, M/285008/01/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 52 p.
47070046 Bongartz, R. (2006) [Dihydrotriazole-3-(14-Carbon)] BYH18636: Extraction
Efficiency of the Residue Analytical Method for the Determination of
BYH18636 Residues in Plant Matrices Using Aged Radioactive Residues.
Project Number: MEF/05/504, M9991546/3, M/274486/01/2. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 52 p.
47070047 Zimmer, D.; Wieland, K. (2006) Analytical Method 00990 for the
Determination of Residues of BYH 18636 and its Metabolites in Animal
Matrices. Project Number: P603065518, M/281559/02/2, 00990. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 188 p.
47070048 Zimmer, D.; Kuppels, U. (2007) Analytical Method 01022 for the
Determination of Residues of BYH18636 and BYH18636-MMT in Animal
Matrices. Project Number: 01022, MR/06/175, D/40789. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 131 p.
47070049 Class, T. (2007) Independent Laboratory Validation of Bayer CropScience
Method No. 01022 for the Determination of Residues of BYH 18636 and its
Metabolite BYH 18636-MMT in Animal Matrices By LC/MS/MS. Project
Number: P1138G, P613065528, M/284346/02/2. Unpublished study prepared
by PTRL Europe Gmbh. 58 p.
47070050 Class, T. (2006) Independent Laboratory Validation of Bayer Cropscience
Method No. 00963 for the Determination of Residues of BYH 18636 and Its
61
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Metabolites BYH 18636-N-Desmethyl and BYH 18636-MMT-Glucoside in/on
Plant Materials by LC/MS/MS. Project Number: PI 125G, P612065524,
M/280706/01/2. Unpublished study prepared by PTRL Europe. 60 p.
47070101 Zimmer, D.; Philipowski, C. (2006) Analytical Method 00963 for the
Determination of Residues of BYH18636 and its Metabolites BYH18636-N-
desmethyl and BYH18636-MMT-glucoside in/on Plant Matrices by HPLC-
MS/MS. Project Number: P602055513, RAUBX009, 00963. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 172 p.
47070107 Billian, P.; Wolters, A. (2007) Magnitude of Residues in/on Wheat Treated with
One Application of the Herbicide AE 1162464 01 OD07 with a 60 Day PHI for
Grain: Analytical Report. Project Number: RAGSP015, MR/06/154,
P672060595. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 118 p.
47070114 Wade, J. (2007) In House Validation of the Analytical Method for the
Determination of Residues of BYH 18636 and its Metabolites BYH 18636-
carboxylic acid, BYH 18636-sulfonamide, BYH 18636-sulfonamide-carboxylic
acid, BYH 18636-MMT, and BYH 18636-dicarboxy Sulfonamide in Water
Using LC/MS/MS . Project Number: RAGSM001, GS/004/W06/02,
M/285955/01/1. Unpublished study prepared by Bayer Corp. 100 p.
47070116 Brumhard, B. (2005) Analytical Method 00893 for the Determination of
Residues of BYH18636 and BYH18636-carboxylic acid in Soil by HPLC-
MS/MS. Project Number: P601040006, 00893, MR/111/04. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 40 p.
860.1360 Multiresidue method
MRID
Citation Reference
47070102 Memmel, A. (2007) PAM I Multiresidue Protocol Testing of BYH18636 and its
Metabolites. Project Number: 1726, RAGSM007, M/285749/01/1. Unpublished
study prepared by Pyxant Labs Inc. 263 p.
860.1380 Storage stability data
MRID
Citation Reference
47070103 Brumhard, B.; Wolters, A. (2007) Storage Stability of BYH18636 and its
Metabolites BYH18636-N-desmethyl and BYH18636-MMT-glucoside in Plant
Matrices for 18 Months - Results for an Interval of 0 to 12 Months. Project
Number: P642055519, MR/186/05. Unpublished study prepared by Bayer Ag,
62
-------
Institute of Product Info. & Residue Anal. 176 p.
47070115 Netzband, D.; Wade, J. (2007) Stability of BYH 18636 and its Metabolites BYH
18636-carboxylic acid, BYH 18636-sulfonamide, BYH 18636 sulfonamide-
carboxylic acid, BYH 18636-MMT, and BYH 18636-triazolinone carboxamide
in Soil During Frozen Storage, USA, 2006 (Through a Maximum of 173 Days
Storage). Project Number: RAGSP041. Unpublished study prepared by Bayer
Corp. 56 p.
47070117 Brumhard, B.; Koch, V. (2007) Determination of the Storage Stability of
BYH18636 and its Metabolite BYH18636-carboxylic acid in Soil During
Freezer Storage of 24 Months Results for an Interval of 0 to 12 Months. Project
Number: P641050019, MR/06/204, M/284985/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 33 p.
47525801 Netzband, D.; Wade, J. (2008) Stability of BYH 18636 and Its Metabolites BYH
18636-carboxylic acid, BYH 18636-sulfonamide, BYH 18636 sulfonamide-
carboxylic acid, BHY 18636-MMT, and BYH 18636-triazolinone
Carboxoamide in Soil During Frozen Storage, USE, 2006. Project Number:
RAGSP041, M/285671/02/1. Unpublished study prepared by Bayer
CropScience. 56 p.
860.1480 Meat/milk/poultry/eggs
MRID
Citation Reference
47070104 Brumhard, B.; Auer, S.; Eberhardt, R. (2007) BYH 18636: Dairy Cattle Feeding
Study. Project Number: P673065520, MR/06/095. Unpublished study prepared
by Bayer Ag, Institute of Product Info. & Residue Anal. 207 p.
860.1500 Crop field trials
MRID
Citation Reference
47070105 Beedle, E.; Harbin, A. (2007) BYH 18636 450 SC and 63 WG - Magnitude of
the Residue in/on Field Corn, Sweet Corn, and Pop Corn. Project Number:
RAGSM010, M/285277/01/1. Unpublished study prepared by Bayer Corp.,
Crop Management Strategies, Inc. and Agricultural Chemistry Development
Services, Inc. (ACDS). 1015 p.
47070106 Vaughn, F. (2007) Magnitude of Residues in/on Wheat Treated with One
Application of the Herbicide AE 1162464 01 OD07 with a 60 Day PHI for
Grain: Final Study Report. Project Number: RAGSP015, MR/06/154,
M/285961/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
63
-------
Info. & Residue Anal., Vaughn Agricultural Research Services and Bayer
CropScience. 264 p.
47114035 Fischer, D. ; Helfrich, K. (2007) Isoxaflutole Plus (Inert Ingredient) - Magnitude
of the Isoxaflutole Residue in/on Field Corn. Project Number: RAUBP008,
Nl06807. Unpublished study prepared by Bayer Corp. and Battelle. 244 p.
860.1520 Processed food/feed
MRID
Citation Reference
47070108 Beedle, E. (2007) BYH 18636 450 SC and 63 WG - Request for Waiver of the
Study of the Magnitude of the Residue in/on Field Corn Processed
Commodities. Project Number: RAGSP005, M/285687/01/1. Unpublished study
prepared by Bayer Corp. and GLP Technologies. 80 p.
47070112 Krolski, M. (2007) BYH18636 63 WG: Magnitude of the Residue in/on Wheat
Processed Commodities. Project Number: RAGSP010, M/283804/01/1, 00963.
Unpublished study prepared by Bayer Corp., GLP Technologies and Bayer
Research Farm. 77 p.
47070113 Mackie, S. (2007) BYH18636 63 WG: Magnitude of the Residue in/on Soybean
Processed Commoities. Project Number: RAGSP011, M/286131/01/1, 00963.
Unpublished study prepared by Bayer Corp., GLP Technologies and Bayer
CropScience Mississippi Field Station. 78 p.
860.1850 Confined accumulation in rotational crops
MRID
Citation Reference
47070033 Reiner, H. (2005) Metabolism of [Dihydrotriazole-3-(14-Carbon)] BYH18636
in Confined Rotational Crops. Project Number: MEF/05/023, M1301272/6,
M/261209/02/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 134 p.
47070034 Justus, K (2006) Metabolsim of [Dihydrotriazole-3-(14-Carbon)] BYH18636 in
Confined Rotational Crops Following Co-application with Safener AE 0001789.
Project Number: MEF/06/215, M1301379/4, M/277504/01/2. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 137 p.
47070035 Justus, K. (2006) Metabolism of [Dihydrotriazole-3-(14-Carbon)] BYH 18636
in Confined Rotational Crops After an Application Rate of 30 g/ha in the
Presence of Safener AE 0001789. Project Number: MEF/06/258, M1301394/1,
M/278990/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 97 p.
64
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47070036 Reiner, H. (2005) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Confined Rotational Crops. Project Number: MEF/05/024, M/1301273/7,
M/260471/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 137 p.
47070037 Justus, K. (2006) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Confined Rotational Crops Following Co-application with Safener AE 0001789.
Project Number: MEF/05/297, M1301380/6, M/275070/01/2. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 128 p.
47070038 Justus, K. (2006) Metabolism of [Thiophene-4-(14-Carbon)] BYH18636 in
Confined Rotational Crops After an Application Rate of 30 g/ha in the Presence
of Safener AE0001789. Project Number: MEF/05/539, M1301395/2,
M/277462/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 97 p.
860.1900 Field accumulation in rotational crops
MRID
Citation Reference
47070109 Mosier, D. (2007) BY18636 63 WG - Magnitude of the Residue in Soybeans
(Rotational Crop Tolerance - 2 Month Plant-Back Interval). Project Number:
RAGSP009, M/285470/01/1. Unpublished study prepared by Bayer Corp.,
Bayer Research Farm and Aventis Cropscience. 351 p.
47070110 Mackie, S. (2007) BYH18636 63 WG - Magnitude of the Residue in Soybean
Rotational Crops (9-Month and 12-Month Plant Back Intervals). Project
Number: RAGSP013, RAGSP014, M/286131/01/1. Unpublished study prepared
by Bayer Corp., Bayer Research Farm and Bayer CropScience Mississippi Field
Station. 257 p.
47070111 Mosier, D. (2007) BYH18636 63 WG - Magnitude of the Residue in Wheat as a
Rotational Crop (Limited Rotational Crop - Wheat). Project Number:
RAGSP008. Unpublished study prepared by Bayer Corp. 310 p.
47070112 Krolski, M. (2007) BYH18636 63 WG: Magnitude of the Residue in/on Wheat
Processed Commodities. Project Number: RAGSP010, M/283804/01/1, 00963.
Unpublished study prepared by Bayer Corp., GLP Technologies and Bayer
Research Farm. 77 p.
47070113 Mackie, S. (2007) BYH18636 63 WG: Magnitude of the Residue in/on Soybean
Processed Commoities. Project Number: RAGSP011, M/286131/01/1, 00963.
Unpublished study prepared by Bayer Corp., GLP Technologies and Bayer
CropScience Mississippi Field Station. 78 p.
870.1100 Acute oral toxicity
65
-------
MRID
Citation Reference
47070119 Schungel, M. (2004) BYH 18636: Acute Toxicity in the Rat After Oral
Administration. Project Number: AT01452, TXGSX006, T/5074266.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 28 p.
47070120 Schungel, M. (2007) BYH 18636 N-desmethyl: Acute Toxicity in the Rat After
Oral Administration. Project Number: TXGSP055, AT03550, T/l077241.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 29 p.
47070121 Schungel, M. (2006) BYH 18636-carboxylic acid (AE 1394083): Acute
Toxicity in the Rat After Oral Administration. Project Number: TXGSP028,
AT02902, T/3076352. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 26 p.
47070205 Schugel, M. (2006) BYH 18636: Acute Toxicity in the Rat after Oral
Administration. Project Number: AT03457, TXGSP054, T5077100.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 26 p.
47070210 Schungel, M. (2006) BYH 18636-Sulfonamide: Acute Toxicity in the Rat After
Oral Administration. Project Number: AT03210, T/8076771, M/277277/01/2.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 26 p.
47070240 Schungel, M. (2006) BYH 18636 + AE 0001789 SC 225 + 225 g/L: Acute
Toxicity in the Rat After Oral Administration. Project Number: AT03052,
T/0076610, M/273331/01/2. Unpublished study prepared by Bayer Ag. 28 p.
47070242 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
47070249 Eiben, R. (2006) BYH 18636 + Mefenpyr-diethyl OD 70: Acute Toxicity in the
Rat After Oral Administration. Project Number: AT03394, T/9077050,
M/279810/01/2. Unpublished study prepared by Bayer Ag. 29 p.
47070250 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070302 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Acute Oral
Toxicity Up and Down Procedure in Rats: (WG 63 Herbicide). Project Number:
20219, P320/UDP. Unpublished study prepared by Product Safety Laboratories.
15 p.
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
66
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prepared by Bayer CropScience LP. 24 p.
47070310 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Acute
Oral Toxicity Up and Down Procedure in Rats: (SC 547 Herbicide). Project
Number: 21163, P320/UDP, M/284724/01/1. Unpublished study prepared by
Product Safety Laboratories. 15 p.
47070316 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP 102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114015 Schungel, M. (2006) BYH 18636 + Isoxaflutole + (Inert Ingredient) SC 90 +
225 150 g/1: Acute Toxicity in the Rat after Oral Administration. Project
Number: AT03049, T/7076608, M/273329/01/1. Unpublished study prepared by
Bayer Ag Inst. of Toxicology. 29 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114036 Schungel, M. (2006) Acute Toxicity in the Rat After Oral Administration:
Isoxaflutole + (Inert Ingredient). Project Number: ATO3188, T5076813,
TXUBP029. Unpublished study prepared by Bayer HealthCare AG. 27 p.
870.1200 Acute dermal toxicity
MRID
Citation Reference
47070122 Schungel, M. (2004) BYH 18636: Acute Toxicity in the Rat After Dermal
Application. Project Number: TXGSX007, AT01445, T/0074270. Unpublished
study prepared by Bayer Ag Inst. of Toxicology. 28 p.
47070211 Schungel, T. (2006) BYH 18636-Sulfonamide: Acute Toxicity in the Rat After
Dermal Application. Project Number: AT03211, T/9076772, M/277279/01/2.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 27 p.
47070241 Schungel, M. (2006) BYH 18636 + AE 0001789 SC 225 + 225 g/L: Acute
Toxicity in the Rat After Dermal Application. Project Number: AT03050,
T/1076611, M/279823/01/2. Unpublished study prepared by Bayer Ag. 28 p.
47070242 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
67
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47070248 Eiben, R. (2006) BYH 18636 + Mefenpyr-diethyl OD 70: Acute Toxicity in the
Rat After Dermal Application. Project Number: AT03393, T0077051,
M/279812/01/2. Unpublished study prepared by Bayer Ag. 30 p.
47070250 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070303 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Acute Dermal
Toxicity Study in Rats - Limit Test: (WG 63 Herbicide). Project Number:
20220, P322/RAT. Unpublished study prepared by Product Safety Laboratories.
15 p.
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
prepared by Bayer CropScience LP. 24 p.
47070311 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Acute
Dermal Toxicity Study in Rats - Limit Test: (SC 547 Herbicide). Project
Number: 21164, P322/RAT, M/284725/01/1. Unpublished study prepared by
Product Safety Laboratories. 15 p.
47070316 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP 102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114016 Schungel, M. (2006) HYN 18636 + Isoxaflutole + (Inert Ingredient) SC 90 +
225 +150 g/1: Acute Toxicity in the Rat After Dermal Application. Project
Number: T/8076609, AT03067, M/279655/01/1. Unpublished study prepared by
Bayer Ag Inst. of Toxicology. 29 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114037 Schungel, M. (2007) Acute Toxicity in the Rat after Dermal Application:
Isoxaflutole + (Inert Ingredient). Project Number: AT03187, TXUBP030,
T/6076814. Unpublished study prepared by Bayer HealthCare AG. 28 p.
870.1300 Acute inhalation toxicity
MRID
Citation Reference
68
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47070123 Pauluhn, J. (2004) BYH 18636: Acute Inhalation Toxicity in Rats. Project
Number: TXGSX008, AT01473, T2073309. Unpublished study prepared by
Bayer Ag Inst. of Toxicology. 84 p.
47070239 Pauluhn, J. (2006) BYH 18636 + AE 0001789 SC 225 + 225 g/L: Acute
Inhalation Toxicity in Rats. Project Number: AT03250, T0076809,
M/277825/01/2. Unpublished study prepared by Bayer Ag. 71 p.
47070242 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
47070247 Folkerts, A. (2006) BYH 18636 + Mefenpyr-diethyl OD 70 (Thiencarbazone-
methyl + Mefenpyr-diethyl OD 10 + 60 G/L): Acute Inhalation Toxicity in Rats.
Project Number: AT03452, M/280714/01/2, T1077052. Unpublished study
prepared by Bayer Ag. 74 p.
47070250 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070304 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Acute Inhalation
Toxicity Study in Rats - Limit Test: (WG 63 Herbicide). Project Number:
20221, P330. Unpublished study prepared by Product Safety Laboratories. 23 p.
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
prepared by Bayer CropScience LP. 24 p.
47070312 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Acute
Inhalation Toxicity Study in Rats - Limit Test: (SC 547 Herbicide). Project
Number: 21165, P330, M/284727/01/1. Unpublished study prepared by Product
Safety Laboratories. 22 p.
47070316 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP 102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114017 Pauluhn, J. (2006) BYH 18636 + Isoxaflutole + (Inert Ingredient) SC 30 + 225 +
150 G/L: Acute Inhalation Toxicity in Rats. Project Number: T2076810,
TXGSP043, M/279825/01/1. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 71 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
69
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M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114038 Pauluhn, J. (2006) Acute Inhalation Toxicity in Rats: Isoxaflutole & (Inert
Ingredient). Project Number: AT03351, TXUBP028, T8076807. Unpublished
study prepared by Bayer HealthCare AG. 72 p.
870.2400 Acute eye irritation
MRID
Citation Reference
47070124 Schungel, M. (2006) BYH 18636: Acute Eye Irritation on Rabbits. Project
Number: TXGSP006, AT02437, T/4075381. Unpublished study prepared by
Bayer Ag Inst. of Toxicology. 22 p.
47070206 Gmelin, C. (2006) BYH 18636-[Inert Ingredient]: Acute Eye Irritation on
Rabbits. Project Number: AT03432, T/4076579, M/280712/01/2. Unpublished
study prepared by Bayer Ag Inst. of Toxicology. 22 p.
47070238 Schungel, M. (2006) BYH 18636 + AE 0001789 SC 225 +225 g/L: Acute Eye
Irritation on Rabbits. Project Number: T/8076555, AT03001, M/272093/01/2.
Unpublished study prepared by Bayer Ag. 23 p.
47070242 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
47070246 Gmelin, C. (2006) BYH 18636 + Mefenpyr-diethyl OD 70: Acute Eye Irritation
on Rabbits. Project Number: AT03305, T/7076590, M/279251. Unpublished
study prepared by Bayer Ag. 23 p.
47070250 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070306 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Primary Eye
Irritation Study in Rabbits: (WG 63 Herbicide). Project Number: 20222, P324.
Unpublished study prepared by Product Safety Laboratories. 18 p.
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
prepared by Bayer CropScience LP. 24 p.
47070313 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Primary
Eye Irritation Study in Rabbits: (SC 547 Herbicide). Project Number: 21166,
70
-------
P324, M/284730/01/1. Unpublished study prepared by Product Safety
Laboratories. 16 p.
47070316 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114018 Gmelin, C. (2006) BYH 18636 + Isoxaflutole + (Inert Ingredient) SC 90 + 225 +
150 g/1: Acute Eye Irritation on Rabbits. Project Number: T/0076584, AT03244,
M/277838/01/1. Unpublished study prepared by Bayer Ag Inst. of Toxicology.
23 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114039 Schungel, M. (2006) Acute Eye Irritation on Rabbits: Isoxaflutole + (Inert
Ingredient). Project Number: AT03287, T/0076575, TXUBP031. Unpublished
study prepared by Bayer HealthCare AG. 23 p.
870.2500 Acute dermal irritation
MRID
Citation Reference
47070203 Schungel, M. (2004) Acute Skin Irritation/Corrosion on Rabbits: BTH 18636.
Project Number: T/3073788, AT01648, M/129093/01/2. Unpublished study
prepared by Bayer Ag Inst. of Toxicology. 21 p.
47070207 Gmelin, C. (2006) BYH 18636-[Inert Ingredient]: Acute Skin
Irritation/Corrosion on Rabbits. Project Number: T/3076578, AT03439,
M/280713/01/2. Unpublished study prepared by Bayer Ag Inst. of Toxicology.
22 p.
47070236 Schungel, M. (2006) BYH 18636 + AE 0001789 SC 225 + 225 G/L: Acute Skin
Irritation/Corrosion on Rabbits. Project Number: T/6076553, AT03000,
M/272076/01/2. Unpublished study prepared by Bayer Ag. 23 p.
47070242 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
47070245 Gmelin, C. (2006) BYH 18636 + Mefenpyr-diethyl OD 70: Acute Skin
Irritation/Corrosion on Rabbits. Project Number: M/279231/01/2, AT03304.
Unpublished study prepared by Bayer Ag. 23 p.
71
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47070250 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070307 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Primary Skin
Irritation Study in Rabbits: (WG 63 Herbicide). Project Number: 20223, P326,
M/283921/01/1. Unpublished study prepared by Product Safety Laboratories. 16
P-
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
prepared by Bayer CropScience LP. 24 p.
47070314 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Primary
Skin Irritation Study in Rabbits: (SC 547 Herbicide). Project Number: 21167,
P326, M/284732/01/1. Unpublished study prepared by Product Safety
Laboratories. 16 p.
47070316 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP 102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114019 Gmelin, C. (2006) BYH 18636 + Isoxaflutole +(Inert Ingredient) SC + 90 + 225
+150 g/1: Acute Skin Irritation/Corrosion on Rabbits. Project Number:
T/9076583, AT03245, M/278731/01/1. Unpublished study prepared by Bayer
Ag Inst. of Toxicology. 23 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114040 Gmelin, C. (2006) Acute Skin Irritation/Corrosion on Rabbits: Isoxaflutole +
(Inert Ingredient). Project Number: AT03299A, TXUBP032, T/9076574.
Unpublished study prepared by Bayer HealthCare AG. 30 p.
870.2600 Skin sensitization
MRID
Citation Reference
47070204 Vohr, H. (2004) BYH 18636: Study for the Skin Sensitization Effect in Guinea
Pigs (Maximization Test According to Magnus and Kilgman). Project Number:
AT01388, M/083284/01/2, T/5073096. Unpublished study prepared by Bayer
72
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Ag Inst. of Toxicology. 31 p.
47070209 Repetto-Larsay, M. (2007) BYH 18636-[Inert Ingredient]: Evaluation of
Potential Dermal Sensitization in the Local Lymph Node Assay in the Mouse.
Project Number: SA/06367, TXGSP004, M/284449/01/2. Unpublished study
prepared by Bayer Cropscience. 36 p.
47070237 Larsay, M. (2006) BYH 18636 + AE 0001789 SC 450 Evaluation of Potential
Dermal Sensitization in the Local Lymp Node Assay in the Mouse. Project
Number: SA/06028, M/279626/01/2. Unpublished study prepared by Bayer
Cropscience. 41 p.
47070242 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-Methyl + Cyprosulfamide SC 225 + 225
g/L: Specification: 102000013579. Project Number: M/284195/01/1.
Unpublished study prepared by Bayer CropScience LP. 24 p.
47070244 Larsay, M. (2006) BYH 18636 + Mefenpyr-Diethyl OD 70 Evaluation of
Potential Dermal Sensitization in the Local Lymp Node Assay in the Mouse.
Project Number: SA/06185, M/279620/01/2. Unpublished study prepared by
Bayer Cropscience. 39 p.
47070250 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product Thiencarbazone-methyl + Mefenpyr-diethyl OD 10 + 60 g/L:
Specification: 102000014337. Project Number: M/284192/01/1. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47070305 Lowe, C. (2006) (Inert Ingredient) + BYH 18636 WG 42 + 21: Dermal
Sensitization Study in Guinea Pigs (Buehler Method): (WG 63 Herbicide).
Project Number: 20224, P328. Unpublished study prepared by Product Safety
Laboratories. 24 p.
47070308 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: (Inert Ingredient) + Thiencarbazone-methyl WG 42 + 21:
(WG 63 Herbicide). Project Number: M/284183/01/1. Unpublished study
prepared by Bayer CropScience LP. 24 p.
47070315 Durando, J. (2007) SP102000016695 (636+747+(Inert Ingredient) SC): Dermal
Sensitization Study in Guinea Pigs (Buehler Method): (SC 547 Herbicide).
Project Number: 21168, P328, M/284733/01/1. Unpublished study prepared by
Product Safety Laboratories. 23 p.
47070316 Zhou, J.; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: SP 102000016695 (636+747+(Inert Ingredient) SC): (SC
547 Herbicide). Project Number: M/284201/01/1. Unpublished study prepared
by Bayer CropScience LP. 24 p.
47114020 Repetto-Larsay, M. (2006) BYH 18636 + IFT + (Inert Ingredient) SC 90 + 225
+ 150 g/1: Evaluation of Potential Dermal Sensitization in the Local Lymph
Node Assay in the Mouse. Project Number: SA/06027, M/271415/01/1.
73
-------
Unpublished study prepared by Bayer Cropscience. 41 p.
47114021 Cunny, H.; Zhou, J. (2007) Summary of the Toxilogical Studies on the Plant
Protection Product Thiencarbazon-methyl + Isoxaflutole + (Inert Ingredient) SC
90 + 225 +150 g/L: Specification: 102000013459. Project Number:
M/284204/01/1, 102000013459. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal.. 24 p.
47114041 Steiblen, G. (2006) Isoxaflutole & (Inert Ingredient) Evaluation of Potential
Dermal Sensitization in the Local Lymph Node Assay in the Mouse. Project
Number: SA/06149, M/278552/01/1. Unpublished study prepared by Bayer
Cropscience. 39 p.
47487101 Zhou, J. (2008) Bayer CropScience to EPA Inquiries Regarding LLNA Studies
on BYH 18636 OD70 Herbicide. Project Number: BCS/08/JZ/0625,
M/303583/01/1. Unpublished study prepared by Bayer Cropscience LP. 16 p.
870.3100 90-Day oral toxicity in rodents
MRID
Citation Reference
47070126 McElligott, A. (2003) BYH 18636: 90-Day Toxicity Study in the Rat by Dietary
Administration. Project Number: SA/02446, M/l04311/01/2. Unpublished study
prepared by Bayer Cropscience. 541 p.
47070127 Carole, L. (2004) BYH 18636: 90-Day Toxicity Study in the Mouse by Dietary
Administration. Project Number: SA/03086, M/000411/01/2. Unpublished study
prepared by Bayer Cropscience. 280 p.
47070128 Odin-Feurtet, M. (2007) BYH 18636-carboxylic acid: 90-Day Toxicity Study in
the Rat by Dietary Administration. Project Number: SA/06035,
LYNX/PSI/N/TXGSP029, M/2892943/01/2. Unpublished study prepared by
Bayer Cropscience. 414 p.
47070220 Lunchick, C. (2007) Assessment of the Non-Dietary Exposure to
Thiencarbazone-methyl from Use on Corn, Wheat, Non-Crop Areas, Turf and
Ornamentals in the United States. Project Number: G201672, M/286068/01/1.
Unpublished study prepared by Bayer CropScience LP. 18 p.
870.3150 90-day oral toxicity in nonrodents
MRID
Citation Reference
47070129 Eigenberg, D. (2007) A 90-Day Toxicity Feeding Study in the Beagle Dog with
Technical Grade BYH 18636: Amended Report. Project Number: 04/S76/WH,
74
-------
201290/1, M/261742/02/1. Unpublished study prepared by Bayer Corp. 587 p.
47070220 Lunchick, C. (2007) Assessment of the Non-Dietary Exposure to
Thiencarbazone-methyl from Use on Corn, Wheat, Non-Crop Areas, Turf and
Ornamentals in the United States. Project Number: G201672, M/286068/01/1.
Unpublished study prepared by Bayer CropScience LP. 18 p.
870.3200 21/28-day dermal toxicity
MRID
Citation Reference
47070213 Zhou, J. (2005) Waiver Request for 21-Day Dermal Study on BYH 18636.
Project Number: BCS/07/JZ/01, M/285873/01/1. Unpublished study prepared by
Bayer CropScience LP. 6 p.
870.3700 Prenatal developmental toxicity study
MRID
Citation Reference
47070130 Langewische, F. (2005) BYH 18636: Developmental Toxicity Study in Rats
After Oral Administration. Project Number: TXGSX012, AT02339, T4062961.
Unpublished study prepared by Bayer Ag Inst. of Toxicology. 845 p.
47070131 Wason, S. (2006) BYH 18636: Developmental Toxicity Study in the Rabbit by
Gavage. Project Number: SA/03350, M/263644/01/2. Unpublished study
prepared by Bayer Cropscience. 268 p.
47070220 Lunchick, C. (2007) Assessment of the Non-Dietary Exposure to
Thiencarbazone-methyl from Use on Corn, Wheat, Non-Crop Areas, Turf and
Ornamentals in the United States. Project Number: G201672, M/286068/01/1.
Unpublished study prepared by Bayer CropScience LP. 18 p.
870.3800 Reproduction and fertility effects
MRID
Citation Reference
47070132 Eiben, R. (2006) BYH 18636: Two-Generation Reproduction Study in the
Wistar Rat by Administration in the Diet. Project Number: TXGSX017,
T7063198, AT03180. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 1170 p.
47070220 Lunchick, C. (2007) Assessment of the Non-Dietary Exposure to
Thiencarbazone-methyl from Use on Corn, Wheat, Non-Crop Areas, Turf and
75
-------
Ornamentals in the United States. Project Number: G201672, M/286068/01/1.
Unpublished study prepared by Bayer CropScience LP. 18 p.
870.4100 Chronic toxicity
MRID
Citation Reference
47070133 Eigenberg, D. (2007) A Chronic Toxicity Feeding Study in the Beagle Dog with
Technical Grade BYII 18636: Amended Report. Project Number: 201497/1,
05/C76/YO, M/284899/02/1. Unpublished study prepared by Bayer Corp. 1033
P-
870.4200 Carcinogenicity
MRID
Citation Reference
47070135
Wason, S. (2006) Carcinogenicity Study of BYH 18636 in the C57BL/6J Mouse
by Dietary Administration. Project Number: SA/04062, M/280301/01/1.
Unpublished study prepared by Bayer Cropscience. 2339 p.
870.4300 Combined chronic toxicity/carcinogenicity
MRID
Citation Reference
47070134 Schladt, L.; Ruhl-Fehlert, C.; Hartmann, E. (2007) BYH 18636: Combined
Chronic Toxicity and Carcinogenicity Study in Wistar Rats (Dietary
Administration for 2 Years). Project Number: TXGSX001, T3073715,
AT03629. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 3111
P-
870.5100 Bacterial reverse mutation test
MRID
Citation Reference
47070136 Herbold, B. (2007) BYH 18636: Salmonella/Microsome Test: Plate
Incorporation and Preincubation Method. Project Number: TXGSP030,
AT03630, T/4076830. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 63 p.
47070137 Wirnitzer, U. (2005) BYH 18636: Salmonella/Microsome Test: Plate
76
-------
Incorporation and Preincubation Method. Project Number: TXGSX019,
AT02274, T/0073262. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 62 p.
47070138 Herbold, B. (2006) BYH 18636 N-desmethyl: Salmonella/Microsome Test:
Plate Incorporation and Preincubation Method. Project Number: TXGSP058,
AT03497, T/9076880. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 63 p.
47070139 Wirnitzer, U. (2006) BYH 18636-carboxylic acid: Salmonella/Microsome Test:
Plate Incorporation and Preincubation Method. Project Number: TXGSX029,
AT01522A, T/6073259. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 62 p.
47070208 Herbold, B. (2006) BYH 18636-[Inert Ingredient]: Salmonella/Microsome Test
Plate Incorporation and Preincubation Method (Project: BYH 18636). Project
Number: AT03605, T/5076444, M/283583/01/2. Unpublished study prepared by
Bayer Ag Inst. of Toxicology. 64 p.
47376806 Herbold, B. (2008) BYH 18636: Salmonella/Microsome Test Using S9 of Male
Mice: Plate Incorporation and Preincubation Method: TXGSP088. Project
Number: AT04414, T/5078019. Unpublished study prepared by Bayer
Healthcare AG. 65 p.
870.5300 In vitro mammalian cell gene mutation test
MRID
Citation Reference
47070140 Herbold, B. (2007) BYH 18636: V79/HPRT-Test in Vitro for the Detection of
Induced Forward Mutations. Project Number: TXGSP053, AT03686,
T/6076832. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 43 p.
47070141 Herbold, B. (2005) BYH 18636: V79/HPRT-Test in Vitro for the Detection of
Induced Forward Mutations. Project Number: TXGSX021, AT02752,
T/l 073263. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 40 p.
47070142 Herbold, B. (2007) BYH 18636 N-desmethyl: V79/HPRT-Test in Vitro for the
Detection of Induced Forward Mutations. Project Number: TXGSP056,
AT03687, T/0076881. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 45 p.
47070143 Herbold, B. (2005) BYH 18636-carboxylic acid: V79/HPRT-Test in Vitro for
the Detection of Induced Forward Mutations. Project Number: TXGSX030,
AT02038, T/9073261. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 38 p.
870.5375 In vitro mammalian chromosome aberration test
77
-------
MRID
Citation Reference
47070144 Thum, M. (2007) BYH 18636: In Vitro Chromosome Aberration Test with
Chinese Hamster V79 Cells. Project Number: TXGSP052, AT03625,
T/5076831. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 51 p.
47070145 Thum, M. (2005) BYH 18636: In Vitro Chromosome Aberration Test with
Chinese Hamster V79 Cells. Project Number: TXGSX020, T/l074271,
AT02499. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 46 p.
47070146 Nern, M. (2007) BYH 18636 N-desmethyl: In Vitro Chromosome Aberration
Test with Chinese Hamster V79 Cells. Project Number: TXGSP059, AT03678,
T/1076882. Unpublished study prepared by Bayer Ag Inst. of Toxicology. 52 p.
47070147 Herbold, B. (2005) BYH 18636-carboxylic acid: In Vitro Chromosome
Aberration Test with Chinese Hamster V79 Cells. Project Number: TXGSX031,
AT01980, T/8073260. Unpublished study prepared by Bayer Ag Inst. of
Toxicology. 54 p.
870.5395 Mammalian erythrocyte micronucleus test
MRID
Citation Reference
47070214 Herbold, B. (2004) Micronucleus-Test on the Male Mouse: (Project: BYH
18636). Project Number: T/2074272, AT01568, M/123179/01/2. Unpublished
study prepared by Bayer Ag Inst. of Toxicology. 49 p.
870.6200 Neurotoxicity screening battery
MRID
Citation Reference
47070148 Gilmore, R.; Hoss, H. (2006) An Acute Oral Neurotoxicity Screening Study
with Technical Grade BYH 18636 in Wistar Rats. Project Number: 05/N12/ZI,
201512, M/279833/01/1. Unpublished study prepared by Bayer Corp. 464 p.
47070149 Gilmore, R.; Hoss, H. (2006) A Subchronic Neurotoxicity Screening Study with
Technical Grade BYH 18636 in Wistar Rats. Project Number: 201518,
05/N72/AD, M/281238/01/1. Unpublished study prepared by Bayer Corp. 645 p.
870.7485 Metabolism and pharmacokinetics
MRID
Citation Reference
78
-------
47070150 Justus, K.; Spiegel, K. (2006) [Dihydrotriazole-3-(Carbon 14)]BYH 18636:
Absorption, Distribution, Excretion and Metabolism in the Rat. Project Number:
M21819148, MEF/06/049, M/275826/01/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal.. 121 p.
47070201 Justus, K. (2006) [Thiophene-(Carbon-14)] BYH18636: Adsorption,
Distribution, Excretion, and Metabolism in the Rat. Project Number:
M41819131, MEF/05/176, M/268447/01/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 153 p.
870.7600 Dermal penetration
MRID
Citation Reference
47070202 Capt, A. (2006) [Carbon 14]- BYH 18636 in SC450 Formulation: Comparative
In Vitro Dermal Absorption Study Using Human and Rat Skin. Project Number:
SA/06151. Unpublished study prepared by Bayer Cropscience. 69 p.
850.6200 Earthworm subchronic toxicity test
MRID
Citation Reference
47069934 Heimbach, F. (2005) BYH 18636 (tech.): Acute Toxicity to Earthworms
(Eisenia fetida) Tested in Artificial Soil. Project Number: E/310/3019/7,
RG/10/05, M/262506/01/2. Unpublished study prepared by Bayer Ag, Institute
of Product Info. & Residue Anal. 22 p.
850.7100 Data reporting for environmental chemistry methods
MRID
Citation Reference
47070043 Netzband, D.; Wade, J. (2007) In House Laboratory Validation of An Analytical
Method For The Determination of Residues of BYH 18636 And Its Metabolites
BYH 18636-Carboxylic Acid, BYH 18636-Sulfonamide, BYH 18636-
Sulfonamide-Carboxylic acid, BYH 18636-MMT, and BYH 18636-
Triazolinone Carboxamide in Soil and Sediment Using LC/MS/MS. Project
Number RAGSP007, M/285741/01/1. Unpublished study prepared by Bayer
Corp. 107 p.
47070044 Brumhard, B.; Koch, V. (2007) Independent Laboratory Validation of Method
79
-------
Gs-003-S06-01 For The Determination of BYH18636 and its Metabolites
BYH18636-Carboxylic acid, BYH18636-Sulfonamide, BYH18636-
Sulfonamide-Carboxylic acid, BYH18636-MMT, and BYH18636-Triazlinone
Carboxamide in Soil and Sediment Using LC/MS/MS. Project Number:
MR/06/155, P611060013, M/285008/01/2. Unpublished study prepared by
Bayer Ag, Institute of Product Info. & Residue Anal. 52 p.
47070114 Wade, J. (2007) In House Validation of the Analytical Method for the
Determination of Residues of BYH 18636 and its Metabolites BYH 18636-
carboxylic acid, BYH 18636-sulfonamide, BYH 18636-sulfonamide-carboxylic
acid, BYH 18636-MMT, and BYH 18636-dicarboxy Sulfonamide in Water
Using LC/MS/MS . Project Number: RAGSM001, GS/004/W06/02,
M/285955/01/1. Unpublished study prepared by Bayer Corp. 100 p.
47070118 Krebber, R.; Leppelt, L. (2007) Independent Laboratory Validation of Method
GS-004-W06-01 for the Determination of BYH18636 and its Metabolites
BYH18636-carboxylic acid, BYH18636-sulfonamide, BYH18636-sulfonamide
carboxylic acid, BYH18636-MMT and BYH18636-dicarboxy sulfonamide in
Water Using LC-MS/MS. Project Number: P/614/067075, GS/004/W06/01,
MR/07/218. Unpublished study prepared by Bayer Ag, Institute of Product Info.
& Residue Anal. 53 p.
870.3050 Repeated dose 28-day oral toxicity in rodents
MRID
Citation Reference
47070125 Rascle, J. (2007) BYH 18636-n-desmethyl (AE 1417257): 28-Day Toxicity
Study in the Rat by Dietary Administration. Project Number: SA/06247,
LYNX/PSI/N/TXGSP057, M/284133/01/2. Unpublished study prepared by
Bayer Cropscience. 382 p.
47070212 Rascle, J. (2007) BYH 18636-Sulfonamide: 28-Day Toxicity Study in the Rat
by Dietary Administration. Project Number: SA/06084, TXGSX032.
Unpublished study prepared by Bayer Cropscience. 300 p.
850.6200 Earthworm subchronic toxicity test
MRID
Citation Reference
47070232 Leicher, T. (2006) BYH 18636 & AE 0001789 SC 450: Acute Toxicity to
Earthworms (Eisenia fetida) Tested in Artificial Soil. Project Number:
E/3103135/6, M/273369/01/2, RG/09/06. Unpublished study prepared by Bayer
Ag, Institute of Product Info. & Residue Anal. 23 p.
80
-------
47070234 Friedrich, S. (2006) BYH 18636 & AE 0001789 SC 450: Sublethal Toxicity to
the Earthworm Eisenia fetida in Artificial Soil: Final Report. Project Number:
M/277481/01/2, 06/10/48/099, ELECTRONIC/COPY. Unpublished study
prepared by BioChem agrar. 32 p.
47114008 Leicher, T. (2006) Thiencarbazone-methyl and Isoxaflutole and (Inert
Ingredient) SC 90 and 225 and 150 g/1: Acute Toxicity to Earthworms (Eisenia
fetida) Tested in Artificial Soil with 5% Peat. Project Number: E/310/3203/2.
Unpublished study prepared by Bayer Ag. 24 p.
Non-Guideline Study
MRID
Citation Reference
47069900 Bayer CropScience LP. (2007) Submission of Product Chemistry, Toxicity,
Fate, Residue, and Risk and Exposure Data in Support of the Applications for
Registration of Thiencarbazone-methyl Technical, SC 450 Herbicide, SC 450
Turf and Ornamental Herbicide, OD 70 Herbicide, SC 547 Herbicide, WG 63
Herbicide and WG 63 Turf and Ornamental Herbicide. Transmittal of 50 of 215
Studies.
47069930 Bruns, E. (2006) Acute Toxicity of BYH 18636 (tech.) to Larvae of Chironomus
riparius in a 48 h Static Laboratory Test System (Limit-Test). Project Number:
E/322/3131/5, EBGSP037. Unpublished study prepared by Bayer Ag, Institute
of Product Info. & Residue Anal. 48 p.
47069931 Frommholz, U. (2006) BYH 18636 tech: Influence on the Reproduction of the
Collembola Species Folsomia Candida Tested in Artificial Soil. Project Number:
E314/3119/2, M/275211/01/2. Unpublished study prepared by Bayer Ag,
Institute of Product Info. & Residue Anal. 26 p.
47069933 Hoberg, J. (2007) BYH 18636 - Comparative Toxicity to Three Aquatic
Macrophytes During a 14-Day Exposure Followed by a 14-Day Recovery
Period. Project Number: EBGSP084, EBGSP085, EBGSP086. Unpublished
study prepared by Springborn Smithers Laboratories. 106 p.
47069935 Luhrs, U. (2006) BYH 18636-MMT: Effects on Reproduction and Growth of
Earthworms Eisenia fetida in Artificial Soil: Final Report. Project Number:
28461022, M/269458/01/2. Unpublished study prepared by Institut fuer
Biologische Analytik und Consulting IBACON. 36 p.
47069937 Friedrich, S. (2006) BYH 18636-MMT: Effects on the Reproduction of the
Collembolans Folsomia Candida: Final Report. Project Number: 06/10/48/167,
M/280552/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 24 p.
47069938 Leicher, T. (2006) BYH 18636-Carboxylic Acid: Effects on Soil Litter
81
-------
Degredation. Project Number: E/427/3060/2, LRT/SLD/30/60, M/280506/02/2.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 57 p.
47069939 Bruns, E. (2006) Acute Toxicity of BYH 18636-Carboxylic Acid to Larvae of
Chironomus riparius in a 48 h Static Laboratory Test System (Limit Test).
Project Number: E/322/3133/7, EBGSP079, M/281173/01/2. Unpublished study
prepared by Bayer Ag, Institute of Product Info. & Residue Anal. 48 p.
47069940 Friedrich, S. (2005) BYH 18636 Carboxylic Acid: Final Report. Project
Number: 05/10/48/058, M/259511/01/2. Unpublished study prepared by Bayer
Ag, Institute of Product Info. & Residue Anal. 28 p.
47069941 Frommholz, U. (2005) BYH 18636-Carboxylic Acid: Influence on the
Reproduction of the Collembola Species Folsomia Candida Tested in Artificial
Soil. Project Number: E/314/2970/6, LKC/COLL/44/05, M/262498/01/2.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 24 p.
47069942 Lechelt-Kunze, C. (2005) BYH 18636-Carboxylic Acid (technical): Effects on
Survival, Growth and Reproduction on the Earthworm Eisenia fetida Tested in
Artificial Soil. Project Number: E/312/2965/8, RG/32/05, LKC/RG/R/17/05.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 42 p.
47069943 Friedrich, S. (2006) BYH 18636-Sulfonamide: Sublethal Toxicity to the
Earthworm Eisenia fetida in Artificial Soil: Final Report. Project Number:
06/10/48/063, M/275605/01/2. Unpublished study prepared by Bayer
Cropscience Gmbh. 34 p.
47069946 Banman, C.; Lam, C. (2005) Toxicity of BYH 18636 [Inert Ingredient] to the
Green Alga Pseudokirchneriella subcapitata. Project Number: EBGSP003,
M/262576/01/1. Unpublished study prepared by Bayer Corp. 45 p.
47069947 Luhrs, U. (2006) BYH 18636-[Inert IngredientJ-Carboxylic Acid: Effects on
Reproduction and Growth of Earthworms Eisenia fetida in Artificial Soil: Final
Report. Project Number: 28471022, M/269975/01/2. Unpublished study
prepared by Institut fuer Biologische Analytik und Consulting IBACON. 39 p.
47069948 Bruns, E. (2006) Acute Toxicity of BYH 18636-[Inert IngredientJ-Carboxylic
Acid to Larvae of Chironomus riparius in a 48 h Static Laboratory Test System
(Limit-Test). Project Number: E/322/3134/8, EBGSP078, MR/06/051.
Unpublished study prepared by Bayer Ag, Institute of Product Info. & Residue
Anal. 49 p.
47069949 Friedrich, S. (2006) BYH 18636-[Inert IngredientJ-Carboxylic Acid: Effects on
the Reproduction of the collembolans Folsomia Candida: Final Report. Project
Number: 06/10/48/168. Unpublished study prepared by Bayer Cropscience
Gmbh. 24 p.
82
-------
47069950 Friedrich, S. (2006) BYH 18636-Triazolinone-Carboxamide: Effects on the
Reproduction of the Collembolans Folsomia Candida: Final Report. Project
Number: 06/10/48/169. Unpublished study prepared by Bayer Cropscience
Gmbh. 24 p.
47070000 Bayer CropScience LP (2007) Submission of Product Chemistry, Toxicity, Fate,
Residue and Risk and Exposure Data in Support of the Applications for
Registration of Thiencarbazone-methyl Technical, SC 450 Herbicide, SC 450
Turf and Ornamental Herbicide, OD 70 Herbicide, SC 547 Herbicide, WG 63
Herbicide and WG 63 Turf and Ornamental Herbicide. Transmittal of 49 of 215
Studies.
47070020 Coukell, G. (2007) Field Dissipation of BYH 18636 in Three Canadian Soils.
Project Number: MEGSP019, M/285968/01/2. Unpublished study prepared by
Bayer CropScience LP, Bayer Corp. and ICMS, Inc. 296 p.
47070039 Fliege, R. (2005) BYH 18636 (AE 1162464): Calculation of the Chemical
Lifetime in the Troposphere. Project Number: MEF/05/299, M1451481/4,
M/267793/01/2. Unpublished study prepared by Bayer Ag, Institute of Product
Info. & Residue Anal. 18 p.
47070100 Bayer CropScience LP (2007) Submission of Product Chemistry, Toxicity, Fate,
Residue and Risk and Exposure Data in Support of the Applications for
Registration of Thiencarbazone-methyl Technical Herbicide, SC 450 Herbicide,
SC 450 Turf and Ornamental Herbicide, OD 70 Herbicide, SC 547 Herbicide,
WG 63 Herbicide, and WG 63 Turf and Ornamental Herbicide. Transmittal of
50 of 215 Studies.
47070200 Bayer CropScience LP. (2007) Submission of Product Chemistry, Toxicity,
Fate, Residue, and Risk and Exposure Data in Support of the Applications for
Registration of Thiencarbazone-methyl Technical, SC 450 Herbicide, SC 450
Turf and Ornamental Herbicide, OD 70 Herbicide, SC 547 Herbicide, WG 63
Herbicide, and WG 63 Turf and Ornamental Herbicide. Transmittal of 50 of 215
Studies.
47070215 Sabbagh, G.; Arthur, E.; Desmarteau, D. (2007) Expected Environmental
Exposure of the Anaerobic Aquatic Degredation BYH 18636-NMT. Project
Number: 201667, M/285652/01/1. Unpublished study prepared by Bayer Corp.
25 p.
47070216 Sabbagh, G.; Arthur, E.; Dallstream, K.; et al. (2007) Drinking Water Exposure
Assessment for BYH 18636. Project Number: MEGSX036. Unpublished study
prepared by Bayer Corp. 94 p.
47070217 Sabbogh, G.; Arthur, E.; Desmarteau, D. (2007) Aquatic Exposure Assessment
for BYH 18636. Project Number: MEGSM007, M/285667/01/1. Unpublished
study prepared by Bayer Corp. 33 p.
47070218 Bowers, L.; Arthur, E.; Dallstream, K.; et. al. (2007) Environmental Fate and
Ecological Risk Assessment for Thiencarbazone-methyl (BYH 18636) for the
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USA and Canada. Project Number: EBGSP036, M/286001/01/1. Unpublished
study prepared by Bayer Corp. 116 p.
47070219 Lemke, V. (2007) Evaluation of the Dietary Exposure to Thiencarbazone-methyl
(BYH 18636) and Assessment of Potential Risk for the U.S. and Canada. Project
Number: RAGSP043, M/285991/01/1. Unpublished study prepared by Bayer
Corp. 57 p.
47070221 Arthur, E. (2007) Bayer CropScience Position and Rationale Document for
Rotational Crop Label Statements Following the Use of Thienecarbazone-
methyl Herbicide. Project Number: 201684. Unpublished study prepared by
Bayer Corp. 14 p.
47070229 Waltersdorfer, A. (2006) Toxicity to the Parasitoid Wasp Aphidius rhopalosiphi
(Destephani-Perez) (Hymenoptera: Braconidae) in the Laboratory BYH 18636
& AE 0001789 SC 225 + 225 g/1. Project Number: CW06/004, M/269942/01/2.
Unpublished study prepared by Bayer Cropscience Gmbh. 28 p.
47070230 Waltersdorfer, A. (2006) Toxicity to the Predatory Mite Typlodromus pyri
Scheuten (Acari, Phytoseiidae) in the Laboratory BYH 18636 & AE 0001789
SC 225 + 225 g/1. Project Number: CW06/006, M/270231/01/3. Unpublished
study prepared by Bayer Cropscience Gmbh. 34 p.
47070300 Bayer CropScience LP (2007) Submission of Product Chemistry, Toxicity, Fate,
Residue, and Risk and Exposure Data in Support of the Applications for
Registration of Thiencarbazone-methyl Technical Herbicide, SC 450 Herbicide,
SC 450 Turf and Ornamental Herbicide, OD 70 Herbicide, SC 547 Herbicide,
WG 63 Herbicide, WG 63 Turf and Ornamental Herbicide. Transmittal of 16 of
215 Studies.
47114000 Bayer CropScience LP. (2007) Submission of Product Chemistry, Toxicity and
Fate Data in Support of the Applications for Registration of SC 465 Herbicide
and SC 480 Herbicide. Transmittal of 42 Studies.
47114005 Waltersdorfer, A. (2006) Toxicity to the Predatory Mite Typhlodromus pryi
Scheuten (Acari, Phytoseiidae) in the Laboratory BYH 18636 and Isoxaflutole
and (Inert Ingredient) SC 90 + 225 + 150 g/1. Project Number: CW06/008.
Unpublished study prepared by Bayer Cropscience Gmbh. 39 p.
47114007 Friedrich, S. (2006) BYH 18636 and (Inert Ingredient) and Isoxaflutole SC 465:
Sublethal Toxicity to the Earthworm Eisenia fetida in Artificial Soil with 5%
Peat: Final Report. Project Number: 06/10/48/100, M/279980/01/1. Unpublished
study prepared by Biochem Agrar, Lab fuer Biologische und Chemische. 34 p.
47114024 Waltersdorfer, A (2006) Toxicity to the Parasitoid Wasp Aphidius rhopalosiphi
(Destephani-Perez) (Hymenoptera: Braconidae) Using an Extended Laboratory
Test Isoxaflutole & Cyprosulfamide SC 240 + 240 g/1. Project Number:
CW06/064, M/279708/01/1. Unpublished study prepared by Bayer Cropscience
Gmbh. 32 p.
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47114025 Waltersdorfer, A. (2006) Toxicity to the Green Lacewig Chysoperla carnea
Steph. (Neuroptera, Chrysopidae) Using an Extended Laboratory Test
Isoxaflutole & Cyprosulfamide SC 240 + 240 g/1. Project Number: CW06/065,
M/279861/01/1. Unpublished study prepared by Bayer Cropscience Gmbh. 27 p.
47114031 Leicher, T. (2006) Isoxaflutole & Cyprosulfamide SC 240 & 240 g/1: Acute
Toxicity to Earthworms (Eisenia fetida) Tested in Artificial Soil with 5% Peat.
Project Number: RG/20/06, E/310/3187/3, LRT/RG/A/74/06. Unpublished
study prepared by Bayer Ag, Institute of Product Info. & Residue Analysis. 23
P-
47114042 Zhou, 1; Cunny, H. (2007) Summary of the Toxicological Studies of the Plant
Protection Product: Isoxaflutole + Cyprosulfamide SC 240+240 g/L. Project
Number: 102000014305, M/283769/02/1, ELECTRONIC/COPY. Unpublished
study prepared by Bayer CropScience LP. 24 p.
47376800 Bayer Cropscience LP (2008) Submission of Efficacy, Toxicity, and Exposure
and Risk Data in Support of the Application for Registration of Thiencarbazone-
methyl Technical Herbicide and the Petition for Tolerance of Thiencarbazone-
methyl for Use on Corn and Wheat. Transmittal of 6 Studies.
47376801 Zhou, J. (2008) Bayer Cropscience Response to US EPA Request for Historical
Control Data in Support of Toxicology Studies Conducted with BYH 18636 and
AE 0001789 - Amended. Project Number: BCS/07/JZ/06, AT/O3629, SA03277.
Unpublished study prepared by Bayer Cropscience LP. 12 p.
47376803 Bowers, L.; Lam, C.; Christ, M. (2007) Bayer Response to PMRA Request for
Clarification with Respect to the BYH 18636 Submission. Project Number:
EBGSY001. Unpublished study prepared by Bayer CropScience. 8 p.
47376807 Kemman, R.; McGaughey, B.; Frank, A.; et al. (2008) Thiencarbazone-methyl
(BYH18636): An Assessment of Risk to Endangered Species Associated with
Corn and Wheat. Project Number: 08706, EBGSP113, EA/00529/00.
Unpublished study prepared by Compliance Services International. 498 p.
47433700 Bayer Cropscience LP (2008) Submission of Toxicity Data in Support of the
Application for Registration of Thiencarbazone-methyl Technical Herbicide.
Transmittal of 1 Study.
47433701 Zhou, J. (2008) Bayer Cropscience Response to PMRA Comments Regarding
Inhalation and LLNA Studies on BYH18636 OD70 Herbicide - EPA Version.
Project Number: BCS/07/JZ/05/EPA, SA/06185, TXGSP050. Unpublished
study prepared by Bayer Cropscience, LP. 14 p.
47487000 Bayer CropScience (2008) Submission of Product Chemistry Data in Support of
the Application for Registration of WG 63 Herbicide. Transmittal of 1 Study.
47487100 Bayer CropScience (2008) Submission of Toxicity and Product Chemistry Data
in Support of the Application for Registration of OD 70 Herbicide. Transmittal
of 2 Studies.
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47492700 Bayer CropScience (2008) Submission of Product Chemistry Data in Support of
the Application for Registration of Thiencarbazone-Methyl Technical Herbicide
(BYH 18636) and the Petition for Tolerance of Thiencarbazone-methyl.
Transmittal of 1 Study.
47525800 Bayer CropScience (2008) Submission of Residue Data in Support of the
Application for Registration of Thiencarbazone-methyl Technical Herbicide and
the Petition for Tolerance of Thiencarbazone-methyl Technical Herbicide.
Transmittal of 1 Study.
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