United States
Environmental Protection
Agency
Final Contaminant Candidate List 3
Chemicals: Screening to a PCCL
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Office of Water (4607M)
EPA815-R-09-007
August 2009
www.epa.gov/safewater
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Table of Contents
1.0 INTRODUCTION 1
2.0 HEALTH EFFECTS DATA ELEMENTS 3
2.1 Dose-Response Data Elements 4
2.2 Categorical Data Elements 5
2.3 Calibration of the Data for Partitioning into Toxicity Categories 6
2.3.1 Dose-Response Data 6
2.3.2 Categorical Data 9
2.4 Combining the Data Elements for Screening 12
3.0 OCCURRENCE DATA ELEMENTS 13
3.1 Finished Water Data 13
3.2 Ambient Water Data 15
3.3 Environmental Release Data 15
3.4 Production Data 16
3.5 Disinfection Byproducts (DBFs) and Drinking Water Treatment Chemicals 16
3.6 Combining the Data Elements for Screening 16
4.0 CRITERIA FOR SELECTING A PCCL 17
4.1 Finished and Ambient Water Concentration Data 17
4.2 Environmental Release Data 18
4.3 Production Data 19
4.4 DBFS and Drinking Water Additives 20
5.0 EFFICACY OF THE FRAMEWORK AS A SCREENING TOOL 20
6.0 REFERENCES 21
7.0 APPENDICES Al-1
Appendix 1. Criteria for Selecting the PCCL Al-1
Appendix 2. Chemicals Passing Screening to the PCCL A2-1
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Table of Exhibits
Exhibit 1: Partition for Screening the Universe 3
Exhibit 2: Potency Distributions for the Health Effects Test Set and Universe Chemicals 7
Exhibit 3: Hodge Sterner Scale for Categorizing Chemicals Based on LD50 Values
(Health Canada, 2005) 8
Exhibit 4: Potency Measures for Universe Data Element Partitioned Based on Toxicity
(mg/kg/day or mg/kg) 9
Exhibit 5: Cancer Grouping and Description under the U.S. EPA 1986 Guidelines 9
Exhibit 6: IARC Cancer Groupings (ITER, 2006) 10
Exhibit 7: Partitioning of Cancer Data Based on TDso Values and Weight of Evidence 11
Exhibit 8: Examples of Potency Data Elements for the Selected Chemical Drawn from
the Universe 12
Exhibit 9: Number of Chemicals with Median Concentrations Distributed through the
Screening Framework by Health Effects Category 14
Exhibit 10: Criteria for Screening Health Effects and Water Categories 18
Exhibit 11: Criteria for Screening Health Effects and Environmental Release Categories 19
Exhibit 12: Criteria for Screening Health Effects and Production Categories 19
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List of Acronyms and Abbreviations
< Less than
< Less than or equal to
> Greater than
> Greater than or equal to
|ig/L Micrograms per liter
CASRN Chemical Abstract Services Registry Number
CCL Contaminant Candidate List
CCL 1 EPA's first contaminant candidate list
CCL 3 EPA's third Contaminant Candidate List
CE Clear evidence of carcinogenicity
CUS/IUR Chemical Update System/Inventory Update Rule
DBFs Disinfection By-Products
DBF-CAN Disinfection By-Product with Carcinogenicity Estimates
DSS-Tox Distributed Structure-Searchable Toxicity
DWEL Drinking water equivalent level
E Equivocal
EE Equivocal evidence of carcinogenicity
EPA United States Environmental Protection Agency
FDA United States Food and Drug Administration
FW/AW Finished Water/Ambient Water
H High probability of causing cancer
HM High moderate probability of causing cancer
IRIS Integrated Risk Information System (EPA)
kg Kilogram
L Liter
L Low probability of causing cancer
LD50 Lethal dose 50; an estimate of a single dose that is expected to cause the
death of 50 percent of the exposed animals; it is derived from experimental
data.
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Ibs
LM
LOAEL
M
Mar
MCLG
MRDD
mg/kg
mg/kg/day
N
NAWQA
NCFAP
NCI
NDWAC
NE
NOAEL
NPDWR
NREC
NTP
NTPMSR
P
PCCL
PPMP
RfD
QSAR
RfD-eq
SE
Pounds
Low moderate probability of causing cancer
Lowest observed adverse effect level
Moderate probability of causing cancer
Marginal probability of causing cancer
Maximum contaminant level goal
Maximum recommended daily dose
Milligrams per kilogram body weight
Milligrams per kilogram body weight per day
Negative
National Water Quality Assessment Program (USGS)
National Center for Food and Agricultural Policy
National Cancer Institute
National Drinking Water Advisory Council
No evidence of carcinogenicity
No observed adverse effect level
National Primary Drinking Water Regulations
National Reconnaissance of Emerging Contaminants
National Toxicology Program
National Toxicology Program multi-species results
Positive
Preliminary CCL
Pesticide Pilot Monitoring Program
Reference dose
Quantitative Structure Activity Relationship
Reference Dose -equivalent
Some evidence of carcinogenicity
Tumorigenic dose 50; The dose-rate which if administered chronically for
the standard life-span of the species will have a 50% probability of causing
tumors at some point during that period.
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TRI Toxics Release Inventory
TS Test Set of chemicals
U Universe
USGS United States Geological Survey
yr Year
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1.0 Introduction
Every five years the United States Environmental Protection Agency (EPA) is required to
publish a list of contaminants (1) that are currently unregulated, (2) that are known or anticipated
to occur in public water systems, and (3) which may require regulations under the Safe Drinking
Water Act (SDWA). This list is known as the Contaminant Candidate List or CCL. SDWA
section 1412(b)(l) requires that in the development of the CCL, EPA consider specific data
sources and include the scientific community. EPA must evaluate substances identified in section
101(14) of the Comprehensive Environmental Response, Compensation, and Liability Act
(CERCLA) of 1980 and substances registered as pesticides under the Federal Insecticide,
Fungicide, and Rodenticide Act (FIFRA). SDWA also requires the Agency to consider the
National Contaminant Occurrence Database established under section 1445(g) of SDWA.
SDWA directs the Agency to consult with the scientific community, including the Science
Advisory Board (SAB). In addition, it directs the Agency to consider the health effects and
occurrence information for unregulated contaminants to identify those contaminants that present
the greatest public health concern related to exposure from drinking water.
EPA interprets the criterion that contaminants are known or anticipated to occur in public water
systems broadly. In evaluating this criterion, EPA considers not only public water system
monitoring data, but also data on concentrations in ambient surface and ground waters, releases
to the environment (e.g., Toxics Release Inventory), and production. While such data may not
establish conclusively that contaminants are known to occur in public water systems, EPA
believes these data are sufficient to anticipate that contaminants may occur in public water
systems and support their inclusion on the CCL. The Agency considered adverse health effects
that may pose a greater risk to life stages and other sensitive groups which represent a
meaningful portion of the population. Adverse health effects associated with infants, children,
pregnant women, the elderly, and individuals with a history of serious illness were evaluated. In
selecting contaminants for the CCL 3, each of the above requirements was met.
SDWA section 1412(b)(l) also requires EPA to determine whether to regulate at least five
contaminants from the CCL every five years. SDWA specifies that EPA shall regulate a
contaminant if the Administrator determines that:
• The contaminant may have an adverse effect on the health of persons;
• The contaminant is known to occur, or there is a substantial likelihood that the
contaminant will occur in public water systems with a frequency and at levels of public
health concern; and
• In the sole judgment of the Administrator, regulation of such contaminant presents a
meaningful opportunity for health risk reduction for persons served by public water
systems.
Once contaminants have been placed on the CCL, EPA identifies if there are any additional data
needs or if there are sufficient information to make a regulatory determination. EPA interprets
these criteria for regulatory determination as more rigorous than what is used to place
contaminants on the CCL.
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EPA developed a multi-step process, based on available data, to characterize occurrence and
adverse health risks a contaminant may pose to consumers of public water systems for inclusion
on the Contaminant Candidate Lists (CCL). The steps involve:
1) Building a broad CCL Universe of potential drinking water contaminants for
consideration (see "Final Contaminant Candidate List 3 Chemicals: Identifying the
Universe" (USEPA, 2009a));
2) Using straightforward screening criteria related to a contaminant's potential to occur in
drinking water and potential for public health concern to narrow the Universe to a
Preliminary CCL (PCCL), and;
3) Using a structured classification approach (e.g., a classification model) as a tool, along
with expert judgment, to develop a proposed CCL from the PCCL (see "Final
Contaminant Candidate List 3 Chemicals: Classification of the PCCL to the CCL "
(USEPA, 2009b)).
4) Providing opportunities for public comment and contaminant nomination (see "Summary
of Nominations for the Third Contaminant Candidate List" (USEPA, 2009c)).
This report focuses on the second step, in which EPA uses an approach to screen chemicals to a
PCCL using the data available from a set of data sources that EPA evaluated for health effects
and occurrence information to compile the CCL 3 Universe.
These data sources have yielded over 6,000 chemicals which populate the CCL 3 Chemical
Universe. Along with the names and identifying characteristics of these chemicals the Universe
is the repository for the health-related and occurrence-related information. This information was
used to screen individual contaminants to determine if they should advance from the Universe to
the PCCL. In the case of health effects, the Universe includes both quantitative and qualitative
information on the hazard and/or dose-response properties of the contaminants. For occurrence,
the Universe includes both quantitative and qualitative information on occurrence in water,
releases to the environment, and amount produced. The process for the selection of data sources
and Universe chemicals is detailed in the document entitled, "Contaminant Candidate List 3
Chemicals: Identifying the Universe " (USEPA, 2009a).
EPA based the screening approach, in part, on the National Drinking Water Advisory Council
(NDWAC) recommendation that screening the Universe of chemicals for selection of the PCCL
should be based on widely available data elements that represent important health effects and
occurrence properties (NDWAC, 2004). NDWAC also recommended that the screening be
versatile, yet as simple as possible, and facilitate the identification of those contaminants most in
need of further consideration through the PCCL to CCL process. EPA considered this an
important goal when establishing the screening criteria.
The basic framework developed by EPA for use in screening is shown in Exhibit 1. Applying
this framework to the CCL 3 Universe groups contaminants categorized by their toxicity along
the vertical axis and by their occurrence on the horizontal axis. It arrays the data in a way that
will allow for a separation of chemicals into those that move to the PCCL based on their toxicity
and occurrence properties (e.g., upper right in Exhibit 1) and those that are not further evaluated
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and remain in the CCL chemical universe (e.g., lower left in Exhibit 1). The type of available
data determines which chemicals move to the PCCL and those that remain in the universe.
Exhibit 1: Partition for Screening the Universe
Health Effects
Occurrence
Low to High Occurrence
Increasing
Toxicity
Do not pass to PCCL
Pass to the PCCL
To adequately represent the broad spectrum of health effects data elements at the screening level,
the toxicity categories must accommodate both dose-response and descriptive data. The
occurrence screening categories must also accommodate a variety of occurrence data elements
such as water concentration, environmental release, or production data.
The challenge in screening is to group the chemicals into categories for health effects and
occurrence using the variety of data elements available in the Universe in a generally equivalent
manner. Section 2.0 describes the approach that was used for grouping the health effects data
elements into the separate toxicity-based categories. Section 3.0 describes the approach that is
used to group the occurrence data elements. The application of the screening framework as a
tool, and the results from screening are discussed in Section 4.0. Appendix 1 summarizes the
screening criteria for each type of data considered. Appendix 2 shows the contaminants and the
data EPA used that moved them to the PCCL for additional consideration in the CCL 3 process.
2.0 Health Effects Data Elements
The toxicity information and health effects data extracted from the data sources are quite varied
(USEPA, 2009a and b). The health data elements that provide toxicity information to populate
Exhibit 1 fall into two major categories:
• Data elements that provide dose-response information (potency)
• Categorical data elements on hazard (mostly related to carcinogenic potential).
Some chemicals come from data sources that provide dose-response data in the form of Lowest
Observable Adverse Effects Level (LOAELs), Lethal Dose 50 (LD50), or Reference Doses and
their equivalents (RfDs and RfD-eq). Some data sources only include descriptive data such as the
positive, negative, or equivocal results from National Toxicology Program (NTP) studies or
International Agency for Research on Cancer (IARC) carcinogen classifications. Still other
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chemicals are in the Universe by virtue of their being on a list, such as the State of California list
of reproductive or developmental toxicants ("Proposition 65") which does not have any
accompanying toxicological data. For this reason, it is important that the screening process for
deriving the PCCL be able to accommodate a variety of health effects data inputs.
After examining the breadth of available health effects data, EPA established five categories for
screening. The five categories are as follows:
• Toxicity Category 1
• Toxicity Category 2
• Toxicity Category 3 (the central tendency grouping)
• Toxicity Category 4
• Toxicity Category 5
The toxicity of the grouping decreases as the number for the grouping increases, with Toxicity
Category 1 being the most toxic grouping and Toxicity Category 5 the least toxic grouping.
Within each Toxicity Category, the partitioning criteria vary depending on the data element used.
The partitioning criteria that place a LOAEL in Toxicity Category 1 differ from the criteria used
for LD50 values that place it in the same category. Both criteria are intended to identify
contaminants of approximately equivalent toxicity. The following sections provide information
on the data elements available in the Universe that reflect the dose-response properties and
categorical or descriptive information for the chemicals in the Universe.
2.1 Dose-Response Data Elements
The NDWAC recommended that screening be based on data elements that demonstrate toxic
effects (i.e., LOAELs, LD50s, Cancer Slope Factors, etc.) rather than on data elements that are
based on no effects (i.e., No observed adverse effect level (NOAELs) or that include uncertainty
factors in their derivation (i.e., RfD-eq). However, because of the limitations on the types of data
available for many of the contaminants, it is not possible to be this restrictive. Of the chemicals
in the universe, about 500 had LOAEL data and about 2,000 had LD50 data. The remainder were
lacking the endpoints recommended by the NDWAC, so EPA used other data elements that
provide quantitative information on dose-response that can be partitioned into the five toxicity
groupings. Major endpoints that fall in this category, in addition to LOAELs and LD50s, are as
follows:
• RfDs and RfD-equivalents: RfDs, Minimal Risk Levels from the Agency for Toxic
Substance and Disease Registry, Tolerable Daily Intakes from the World Health
Organization (WHO), Acceptable Daily Intakes from WHO and the Food and Drug
Administration (FDA), Public Health Goals from California EPA, and Tolerable Upper
Intake Levels from the Institute of Medicine.
• NOAELs - No Observed Adverse Effect Levels.
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• TD50s - The dose-rate which if administered chronically for the standard life-span of the
species will have a 50% probability of causing tumors throughout that period. Chemicals
with TDso data have positive cancer results in at least one study.
• Maximum Recommended Daily Dose (MRDD) - Recommendations for the maximum
adult daily therapeutic doses for pharmaceuticals (FDA).
Including the measures of toxic potency listed above in the health effects screening framework
expands the number of chemicals from the Universe that can be screened on the basis of their
dose-response for possible inclusion in the PCCL. The approach used to partition each of these
toxicity measures for screening is described in Section 2.3.
2.2 Categorical Data Elements
There are three groups of categorical data elements and health effects information in the
Universe. These groups categorize chemicals according to their carcinogenic potential,
mutagenicity information, or classification as a developmental or reproductive toxicant.
Categorical data sets in the Universe include the following:
• U.S. EPA Cancer Groupings
• IARC Cancer Groupings
• NTP weight-of-evidence findings from cancer bioassays
• National Cancer Institute (NCI) weight-of-evidence findings from cancer bioassays
• California EPA list of chemicals suspected of causing cancer
• EPA Water Disinfection By-Products with Carcinogenicity Estimates (DBF-CAN)
groupings based on carcinogenic potential derived from Quantitative Structure Activity
Relationship (QSAR) projections and expert judgment
• California list of chemicals suspected of being developmental or reproductive toxicants
• U.S. EPA groupings of disinfection by-products (DBFs) based on QSAR predictions of
their ability to cause developmental or reproductive toxicity.
Even with the expansion of the types of dose-response data suitable for screening described in
Section 2.1, many chemicals in the Universe lack dose-response data elements making it
important to use the categorical information at this screening stage.
The categorical cancer information is amenable to the screening approach illustrated in Exhibit 1
because, in most cases, it includes subcategories related to the strength of the cancer data and its
applicability to humans.
The second group of categorical data elements provides information on genotoxicity and
mutagenicity. This group is considered categorical because results are classified as positive,
negative, or equivocal. However, it is common to have multiple genotoxicity assays for any
given chemical, and it is unusual for all assays of a given chemical to have the same result.
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Accordingly, there is a need to integrate all of the genotoxicity results and determine a
categorical weight-of-evidence if the data are to be useful for screening. However, the Universe
contained few weight-of-evidence findings on genotoxicity, and, when such results are available,
they are usually tied to cancer assessments with dose-response measures. Accordingly, the use of
the categorical cancer information along with TDso dose-response data reduces the importance of
including genotoxicity as a screening criterion. The genotoxicity data remain available as a
supplemental health effects element that can be applied in the evaluation of the PCCL and in
making decisions for chemicals that fall close to the screening barrier that separates the
chemicals that will move to the PCCL from those that will remain in the Universe.
The third type of categorical information in the database comes from the State of California's list
of reproductive and developmental toxicants or other similar lists. These lists are groupings that
are based on a single toxicological property, but not partitioned by the degree of hazard. In this
respect the lists are different from the cancer information that includes subdivisions based on the
hazard weight-of-evidence and supported by quantitative cancer slope factors and/or TD50
values. For this reason, the California list of developmental and reproductive toxicants and the
California list of carcinogens are not used for the screening framework but they are retained as
supplemental information that may be useful in the evaluation of the initial PCCL screening
results.
2.3 Calibration of the Data for Partitioning into Toxicity Categories
2.3.1 Dose-Response Data
As mentioned in the previous section, the health effects information found in the Universe is
diverse. Accordingly, the challenge in screening is to be able to partition each type of data
element into the five toxicity-based categories in a reproducible and logical manner. The main
data elements proposed for screening (RfD-eq, NOAEL, and LOAEL values) have been used by
EPA in establishing Maximum Contaminant Level Goals (MCLGs) or Lifetime Health
Advisories. Accordingly, it was possible to compile a set of test chemicals (TS) found in
drinking water that had multiple data elements from the set of toxicity data (i.e., RfD-eq,
NOAEL, LOAEL, LDso) and examine the range and distribution of values associated with each
dose-response data element. Distributions were also determined for the other measures of dose-
response found in the Universe (U) at the time the screening process was developed (i.e.,
LOAELs, LDsoS, MRDDs, TDsos). Each measure of toxicity covered a range of close to ten
orders of magnitude and had a roughly normal distribution when arrayed according to their logic
value rounded to a single significant figure (Exhibit 2). Each data set is skewed toward higher
potency chemicals due to the difficulty in identifying conventional toxicity data for many
chemicals that are slightly or practically nontoxic. The RfDs and NOAELs in the Universe were
not initially compiled.
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Exhibit 2: Potency Distributions for the Health Effects Test Set
and Universe Chemicals
Log
<-7
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
RfD-eq
TS
1
1
8
59
105
121
63
11
4
O
NOAEL
TS
5
21
45
92
106
29
13
LOAEL
TS
1
2
13
28
63
121
85
28
1
U
O
4
15
52
83
120
139
73
8
MRDD
U
3
4
15
53
183
271
453
223
12
TD50
U
3
8
17
53
184
266
272
139
25
1
LD50
TS
0
0
9
11
45
75
40
1
U
1
1
10
26
239
1023
672
19
TS = Test Set, U= Universe
The TS for RFDs includes chemicals on the IRIS as well as those with MCLGs
and/or Health Advisory values
A reference point for the potency of drinking water was established by converting the 2 L/day,
90 percentile drinking water intake (used by the Office of Water for risk analyses), into a
NOAEL equivalent mg/kg/day dose for 70 Kg adults. This dose equivalent, for perspective,
would occur in the Log 5 cell in the NOAEL health effects diagnostic set. Including this dose-
response value for drinking water allows all other contaminants to be viewed in perspective as
they relate to the CCL screening framework (in Exhibit 2).
EPA evaluated the distribution of the Test Set or the Universe dose-response parameters shown
in Exhibit 2. EPA defined the modal grouping from the distribution for each type of toxicity
parameter as Toxicity Category 3 for screening. The higher and lower screening toxicity
categories were partitioned from the remainder of the distribution based on its shape and the
numeric groupings of chemicals above and below the modal grouping. For most parameters other
than the LD50 values, partitioning was based on powers of 10 and a desire to be more inclusive
rather than exclusive during the screening process, especially during initial testing.
There is a discrepancy between the modal LOAEL in the Universe and that from the Test Set.
The data from the Universe have a modal value that is one logio unit less toxic than that for the
Test Set (Exhibit 2). A decision was made by EPA to base Toxicity Category 3 LOAEL
grouping on the Test Set rather than the universe because the combination of the Office of Water
Health Advisory chemicals and those on Integrated Risk Information System (IRIS) that made
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up that set is more representative of chemicals that EPA had found to be of environmental and/or
regulatory concern than the Universe compilation.
The partitioning for the LDso values was treated differently from the RfD-eq, NOAEL, and
LOAEL values because there has long been an accepted categorization of LDso values into six
categories. The Hodge Sterner scale is shown in Exhibit 3 (Hodge Sterner, 1956). The six
categories were reduced to the five screening categories by combining the two lowest toxicity
categories from the Hodge Sterner Scale.
Exhibit 3: Hodge Sterner Scale for Categorizing Chemicals
Based on LD50 Values (Health Canada, 2005)
Extremely Toxic
Highly Toxic
Moderately Toxic
Slightly Toxic
Practically nontoxic
Relatively harmless
<1 mg/kg
1 - <50 mg/kg
50 - <500 mg/kg
500 - <5000 mg/kg
5000 -<1 5000 mg/kg
> 15000 mg/kg
The MRDD values were partitioned as if they were LOAELs because the maximum therapeutic
doses are established by balancing their benefit with their risk. Accordingly, although MRDD
doses are safe for human consumption, some adverse effects are always possible, especially in
sensitive populations. This situation justifies considering them as LOAELs rather than NOAELs.
The partitioning of the TD50 values was unique in that they apply to the probability for tumor
development. They were, accordingly, combined with the categorical data elements that are
discussed in Section 2.3.2.
Exhibit 4 illustrates how the Universe dose-response data elements partition into their toxicity
categories for screening. The partitioning considered both the distribution of the data for each of
the health effects data elements and the number of contaminants that would fall in each of the
toxicity categories. The testing of the partitioning for the third CCL (CCL 3) Universe at the time
of protocol development suggested that the approach performed reasonably well. Its performance
can be further evaluated and modified if needed for future CCLs.
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Exhibit 4: Potency Measures for Universe Data Element Partitioned
Based on Toxicity (mg/kg/day or mg/kg)
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
RfD
O.0001
0.0001 -O.001
0.001 -<0.05
0.05 -<0.1
>0.1
NOAEL
<0.01
0.01 -< 1
1 -<10
10 -< 1000
>1000
LOAEL
<0.01
0.01 -<1
1 -<10
10-<1000
>1000
MRDD
<0.01
0.01 -<1
1 -<10
10 -< 1000
>1000
LD50
<1
1 -<50
50 - <500
500 - <5000
>5000
2.3.2 Categorical Data
As discussed in Section 2.0, the categorical data selected for screening were primarily those that
applied to cancer and provided a weight-of-evidence evaluation for the probability that the agent
was carcinogenic to humans. The data from the EPA include either an alpha-numeric grouping or
a weight-of-evidence statement on carcinogenic potential and often a cancer slope factor. The
alpha-numeric groupings (Exhibit 5) apply to the chemicals evaluated for their carcinogenicity
under the Guidelines for Carcinogen Risk Assessment (USEPA, 1986).
Exhibit 5: Cancer Grouping and Description under the
U.S. EPA 1986 Guidelines
Group
A
Bi
B2
C
D
E
Description
Human carcinogen
Probable human carcinogen
Limited evidence in animals and inadequate or no evidence
in humans
Possible human carcinogen
Not classifiable as to human carcinogenicity
Evidence of noncarcinogenicity in humans
In 1996 and 1999 the U.S. EPA issued draft updated guidelines for evaluating carcinogenicity.
EPA finalized the revised guidelines in 2005 (USEPA, 2005). Chemicals evaluated under the
2005 Guidelines and its drafts are grouped according to five weight-of-evidence descriptors as
follows:
• Carcinogenic to humans
• Likely to be carcinogenic to humans
• Suggestive evidence for carcinogenicity
• Insufficient evidence to determine carcinogenicity
• Not likely to be carcinogenic
IARC uses a Numeric-Alpha grouping for carcinogens (ITER, 2006) that is similar to the 1986
U.S. EPA groupings. Exhibit 6 summarizes the IARC cancer groupings. The Health Canada
groupings are derived from the IARC system but use Roman numerals I through V for the five
IARC groupings (ITER, 2006).
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Exhibit 6: IARC Cancer Groupings (ITER, 2006)
Group
1
2A
2B
O
4
Description
Carcinogenic to humans
Probably carcinogenic to humans
Possibly carcinogenic to humans
Not classifiable as to its carcinogenicity to humans
Probably not carcinogenic to humans
The data abstracted from the NTP database on cancer studies are those from studies conducted
by both the NTP and the NCI. The NTP (2005) describes the results of the studies as:
• Clear evidence of carcinogenicity (CE)
• Some evidence of carcinogenicity (SE)
• Equivocal evidence of carcinogenicity (EE)
• No evidence of carcinogenicity (NE)
The NTP studies are conducted using groups of male and female rats and/or mice. The results in
both species and both sexes have separate weight-of-evidence determinations. "Clear evidence"
in both species and both sexes is stronger evidence that a chemical could be a potential human
carcinogen than "clear evidence" in only two species-one sex, or in two sexes-one species. Clear
evidence is stronger than some evidence and some evidence stronger than equivocal evidence.
EPA took these distinctions into account when partitioning chemicals based on their NTP
categorical cancer data.
The NCI was responsible for conducting cancer studies for the U.S. Public Health Service prior
to the formation of the NTP. They used a simpler system (NTP, 2005) by reporting results from
cancer bioassays as either positive (P), negative (N) or equivocal (E). The NCI findings are
reported in the NTP database. NCI Studies were also conducted in both sexes for rats and mice.
The studies with positive results in both species and both sexes are those that present the highest
level of concern regarding the potential for human carcinogenicity.
The DBF-CAN data grouping within the EPA Distributed Structure-Searchable Toxicity (DSS-
Tox) database is a compilation of projections on carcinogenic potential, of an assortment of
unregulated DBFs, derived from QSAR modeling and expert judgment. The chemicals are
categorized according to the estimated probability that they will cause cancer from high (H) to
unlikely (L) with intermediary probabilities of high moderate (HM), moderate (M), low
moderate (LM) and marginal (Mar).
EPA placed the qualitative and quantitative data for carcinogenicity of chemicals only in the
upper three toxicity categories. Carcinogens are not generally considered as having low toxicity.
The cancer screening criteria are based on USEPA, IARC, and NTP cancer groupings for
screening rather than the cancer slope factors because many chemicals are categorized for cancer
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but do not have cancer slope factors. Therefore use of the categorical data is more inclusive than
use of slope-factor data.
An exception to using the categorical data for the screening for the cancer endpoint is the
data. The TDso data set includes quantitative estimates of cancer risk for some chemicals that are
not in the other data sets, and thus they will be used in screening in cases where no categorical
cancer data elements are available.
EPA partitioned the cancer-related data elements in the Universe as described in Exhibit 7.
Quantitative measures of dose-response for carcinogenicity will be used in scoring the Potency
attribute for potential carcinogens in the PCCL to CCL process (see the PCCL to CCL Report,
USEPA, 2009b) but not in screening at the Universe level.
Exhibit 7: Partitioning of Cancer Data Based on TD50
Values and Weight of Evidence
Toxicity
Category 1
Toxicity
Category 2
Toxicity
Category 3
TD50
<0.1
0.1 -
100
>100
EPA
Group A;
Human
Carcinogen
Groups B 1 and
B2; likely
carcinogens
Group C;
Suggestive
evidence of
carcinogenicity
IARC
/HC
Group 1
Group 2A
Group 2B
NTP
CE 2 species/2
sexes; or 2
species; or 2
sexes
Combinations
of CE, SE, EE,
andNE
Combinations
ofSE,EE, and
NE
NCI
P 2 species/2
sexes; or 2
species; or 2
sexes
Combinations
of P, Band N
Combinations
ofEandN
DSS-Tox
H
HM
Mand
LM
* * Cancer data placed chemicals in only the three highest Toxicity Categories
CE = clear evidence, SE = some evidence, EE = equivocal evidence, NE = no evidence
P= positive, N= Negative, E = equivocal
H = high probability, HM= high to medium probability, M = medium probability, LM = medium to
low probability
The U.S. EPA Groups D and E, "Insufficient Evidence" and "Not Likely" descriptors, as well as
the IARC Group 3 and 4 or Health Canada Groups IV or V, are not used when partitioning the
categorical data elements as described in Exhibit 7. The DSS-Tox, "unlikely" and TDso, "NP"
field entries are also not used. EPA's decision is based on the premise that low toxicity concerns
related to low tumorigenic properties do not mean there is no systemic toxicity for a
contaminant. In these cases, other non-cancer data were used for screening.
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2.4 Combining the Data Elements for Screening
As discussed in this report, there are a variety of data elements available in the Universe that can
be used to screen for adverse health effects. To avoid favoring chemicals with rich data sets, the
EPA evaluated all available dose-response and categorical data elements for a given chemical in
the screening process. When each of the data elements for a given chemical is placed in the
screening framework, the most conservative health effects category is identified. Accordingly, if
there is just one data element that places a chemical in Toxicity Category 1 it will be categorized
as such even if some of the other data elements for that same chemical place it a lower toxicity
category. For example, if a chemical is classified as a 2A carcinogen by IARC it will be placed
in Toxicity Category 2 even if its LOAEL from a different study places it in Toxicity Category 3.
Exhibit 8 includes several examples drawn from the Universe of chemicals that have either one
or multiple available potency data elements. The data elements used to evaluate the chemicals
are bolded.
Exhibit 8: Examples of Potency Data Elements for the Selected
Chemical Drawn from the Universe
Chemical
4-Biphenylamine
Hexane
Methylazoxy-
methanol acetate
Molybdenum oxide
3 -hydroxycarbofuran
Methylenediphenol
BMX-1
Primiphos methyl
Toxicity
Category 1
Group 1
Toxicity
Category 2
TD50
LD50
DBF-CAN
NOAEL
Toxicity
Category 3
Group 2B
NTP
LOAEL
RfD-eq
LOAEL
Toxicity
Category 4
LD50
LD50
LD50
LOAEL
Toxicity
Category 5
RfD-eq
Four of the contaminants in Exhibit 8 have more than one health effects data element. Each
health effects data element for a chemical will be used for the screening process but the one data
element demonstrating the highest potency in combination with its measure of occurrence will
determine if it is selected for the PCCL. For example, 4-biphenylamine falls in Toxicity
Category 1 because it has an IARC Group 1 classification even though its TD50 places it in
Toxicity Category 2. Hexane falls in Toxicity Category 4 based on its LDso value even though its
RfD-eq value would place it in Toxicity Category 5.
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3.0 Occurrence Data Elements
EPA found that data elements representing a chemical's potential to occur in drinking water vary
greatly in terms of the occurrence factor they represent. The goal was to determine which data
elements best represented the potential to occur in drinking water. EPA considered and evaluated
data elements in the following categories:
• Finished Water - measures concentration and frequency of detections
• Ambient Water - measures concentration and frequency of detections
• Total Releases in the Environment - measures pounds per year and number of states
• Pesticide Application Rates - measures pounds per year and number of states
• Production volume - measures pounds per year
In addition to evaluating quantitative data elements, EPA also analyzed chemicals with
descriptive data based upon their likelihood of occurring in drinking water. Examples of these
types of chemicals include disinfection byproducts and drinking water treatment additives. The
following sections describe the occurrence categories and how EPA utilized them in the
development of the screening criteria.
To analyze the occurrence data and develop the screening criteria, EPA assembled a diagnostic
test set of approximately 200 chemicals. Some of these chemicals were selected from past CCLs
and National Primary Drinking Water Regulations (NPDWRs), and some were randomly pulled
from the Universe of contaminants considered for the draft CCL 3. Most of them had data on
concentrations in water, environmental release and production, and as such constituted a
relatively complete set of occurrence data elements.
3.1 Finished Water Data
Using the Universe as a starting point, EPA considered data elements that are readily available
for chemicals in finished water. The finished water data elements are from the National
Contaminant Occurrence Database (unregulated contaminant monitoring) Rounds 1 and 2, the
National Inorganic Radionuclides Survey, the Unregulated Contaminant Monitoring Regulation
monitoring, the Information Collection Rule database for DBFs, U.S. Department of Agriculture
Pesticide Data Program (PDF), and Pesticides Pilot Monitoring Program (PPMP) (USGS and
USEPA).
The finished water data elements evaluated include:
• percent of samples with detections,
• percent of public water systems with detections,
• median concentration of detections,
• mean concentration of detections, and
• maximum concentration of detections.
The median, mean, and maximum concentration values are based on analytical detections only.
Non-detections were not included in these concentration measure calculations. In both the data
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sets for finished and ambient water (Section 3.2), some chemicals had no detections at any of the
sites surveyed. Some data sets included mean, median, and maximum values whereas others
included only one or two of the data elements.
For screening purposes, EPA determined that the concentration data were the most appropriate
data elements because they have a more direct relationship with dose-response than the detection
frequency. The concentration data ranged from <0.1 (ig/L to >10,000 ng/L. The range was
subdivided using powers often. Some chemicals had finished water data available from multiple
sources; in those cases, the highest value was used for the purposes of screening.
Using the toxicity categories EPA arrayed 107 chemicals with finished water data based on their
toxicity data elements and their median concentration in finished water as shown in Exhibit 9.
This Exhibit illustrates the distribution of chemicals across the categories. EPA developed
additional analyses that focused on the specific chemicals within the different occurrence
categories to set the screening criteria.
Exhibit 9: Number of Chemicals with Median Concentrations
Distributed through the Screening Framework by Health Effects
Category
Health Effects Categories
Toxicitv Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Total
Occurrence - Finished Water - Median (ug/L)
0-
<0.1
1
0
0
0
0
1
0.1-
<1
7
5
8
4
1
25
1-
<10
22
15
16
6
2
61
10-
<100
0
8
3
0
1
12
100-
<1,000
4
0
0
1
0
5
1K-
<10K
1
0
0
0
0
1
>10K
0
0
1
1
0
2
Totals
35
28
28
12
4
107
Exhibit 9 shows that about 82% (87 of 107) of the chemicals with finished water data have
median concentrations less than 10 |ig/L, a concentration that is not of high concern for Toxicity
Category 3 to Toxicity Category 5 chemicals. This grouping would have a maximum drinking
water equivalent level (DWEL) of > 40 |ig/L based on an RfD of 0.001 (see Section 4.1 for
additional information). However, these same concentrations for finished water are of greater
concern for chemicals with Toxicity Category 1 and Toxicity Category 2 RfDs. These types of
analyses helped EPA evaluate the effectiveness of the screening framework as a tool to separate
chemicals of high concern from those of low concern, especially for chemicals with finished
water data.
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3.2 Ambient Water Data
EPA obtained data on ambient water values from the United States Geological Survey (USGS)
National Water Quality Assessment Program (NAWQA), the USGS National Reconnaissance of
Emerging Contaminants (NREC), and the PPMP. The NAWQA data include all the nationwide
data from Cycle 1 of NAWQA, which encompasses data collected from 1992 to 2001. The
NRECs database includes occurrence data collected by the USGS Toxic Substances Hydrology
Program from 1999 to 2001 in samples from 142 streams, 55 wells, and seven effluent samples
from 36 states. The PPMP data includes pesticide concentrations in water, and the sampling
methods include 178 different pesticides and degradation products.
The ambient water data elements analyzed include:
• percent of samples with detections,
• percent of sites with detections,
• median concentration of detections,
• mean concentration of detections, and
• maximum concentration of detections.
As was the case for finished water, the median, mean, and maximum values are based on
analytical detections only. Non-detections were not included in the concentration datasets. The
subdivisions for the data were developed by first determining the range of available ambient
water concentration data, and then partitioning the range by powers often. In this case, the
concentration data ranged from <0.01 ng/L (for all concentration data) to >10,000 |J,g/L. One of
the data sources, NREC, did not contain mean or maximum concentration data, so it was only
represented in the percent of samples, percent of sites, and median concentrations. EPA
developed matrices similar to Exhibit 9 for all of the ambient water data elements using the set of
200 diagnostic chemicals.
3.3 Environmental Release Data
The environmental release data are those reported for 2002 from the Toxics Release Inventory
(TRI) and the National Pesticide Use Database, as created by the National Center for Food and
Agricultural Policy (NCFAP). The most recent version of the NCFAP database was released in
2000, and reflects pesticide use in 1997.
The environmental release data elements considered include:
• total releases to the environment (Ibs/yr)
• number of states with total releases
• pesticide application (Ibs/yr)
• number of states with pesticide application
As was the case for the finished and ambient water data, EPA chose to use the data on the
pounds per year released to the environment for screening rather than the number of states with
releases. The subdivisions used for release data were developed by first determining the range of
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release values represented by the data, and then partitioning the range based on powers often. In
this case, the release data ranged from less than 10 pounds per year to greater than 10 million
pounds per year. EPA developed matrices similar to Exhibit 9 for all of the environmental
release data elements.
3.4 Production Data
The data used to assess production volume are the Toxic Substances Control Act chemical
production volume ranges reported under the Chemical Update System/Inventory Update Rule
(CUS/IUR). EPA used the most recent year of data available for each particular chemical. Every
chemical on EPA's High Production Volume list is also in the CUS/IUR data source. Therefore,
CUS/IUR is the primary source for production data.
CUS/IUR reports chemical production data as ranges rather than as exact values. Therefore, EPA
chose to use those ranges as the subdivisions for the production occurrence data. The production
data ranges from less than 10,000 Ibs/yr to greater than 1 billion Ibs/yr. EPA developed matrices
similar to Exhibit 9 for all of the production data on the test set chemicals.
3.5 Disinfection Byproducts (DBFs) and Drinking Water Treatment
Chemicals
EPA recognized that two groupings of chemicals have water occurrence even in cases where
quantitative data were not available: the DBFs from the DSS-Tox data source and the treatment
chemicals from NSF Standard 60. In many cases there were finished water data or production
data for some of these chemicals, but some of the chemicals lacked quantitative data. Among the
Universe of chemicals that lacked the preferred data elements, both the DBFs and treatment
chemicals have a strong potential to be present in drinking water. Accordingly, EPA is moving
chemicals in these two categories forward to the PCCL for further evaluation, even when limited
health effects or occurrence information are available.
3.6 Combining the Data Elements for Screening
EPA selected the occurrence data elements for screening based upon their presence in the
universe and their suitability as a screening tool. Analyses were performed to see if the
occurrence could be correlated across the various data elements. The diagnostic chemicals were
used for the correlation analysis since most had data for the following data elements: mean,
median, or maximum concentrations in finished and/or ambient water, amount released to the
environment, and production volume. The analyses with the diagnostic chemicals demonstrated a
limited correlation across the data elements. A chemical with a high release to the environment
did not necessarily occur in finished or ambient water at a high concentration or even have a high
frequency of detections. As a result, EPA decided to apply the occurrence screening data
elements in a hierarchical manner.
Chemicals known to occur in finished or ambient water occupy the highest position in the
hierarchy and are most representative of a chemical's potential to occur in drinking water.
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Environmental releases and production are less reflective of a chemical's potential to occur in
drinking water. Accordingly, EPA selected the following hierarchy:
Finished Water = Ambient Water > Environmental Release Data > Production Data.
EPA also decided that when multiple values exist for the chemicals within a given component of
the hierarchy, the most conservative would be used as the occurrence screening element. For
example, in the case of a chemical that has finished water data and ambient water data, the
highest available numerical concentration value would be selected as the occurrence screening
data element.
4.0 Criteria for Selecting a PCCL
The last step in the screening process was to use the intersections between health effects and
occurrence data elements to establish the criteria for moving chemicals from the Universe to a
PCCL. EPA grouped the Universe of chemicals that had values for health effects and occurrence
data elements using the screening framework described in Section 1.0. Because the chemicals
would be evaluated using a hierarchical approach for their occurrence elements, separate criteria
were developed for each of the occurrence elements.
To test the criteria, EPA used the set of 200 diagnostic chemicals. As stated in Section 3.0, the
set of diagnostic contaminants included some chemicals regulated through NPDWRs, some from
past CCLs, and a few drawn from the Universe because they had fairly complete data for all of
the occurrence data elements. The selected regulated chemicals represented the characteristics of
chemicals that the screening process should move to the PCCL. Accordingly, the locations of
these chemicals in the completed screening framework were used to assist in placing the barrier
separating those chemical contaminants that would move to the PCCL from those that would not
be further evaluated. The series of criteria are described in the following sections and
summarized in Appendix 1.
4.1 Finished and Ambient Water Concentration Data
As mentioned earlier, the finished and ambient water data are those most representative of
contaminants likely to be found in drinking water. For this reason EPA scrutinized these data
elements more closely than the other occurrence data elements. Initially, the placement of the
bold black line on Exhibit 10 was positioned so that it would move the regulated chemicals and
most of the past CCL chemicals to the PCCL. Past CCL contaminants that remained in the
Universe and did not pass on to the PCCL (fell to the gray side of the black line) were ones
proven to be poor candidates for regulation.
The second tool used to evaluate the position of the black line was the DWEL. The DWEL is
calculated by multiplying the RfD in mg/kg/day by an adult body weight of 70 kg and dividing
by a drinking water intake of 2 L/day (rounded to one significant figure). The RfD is a dose that
is estimated to be without adverse effects for even sensitive populations. It includes a margin of
safety in the form of a composite uncertainty factor. Most often, the uncertainty factor is a value
of 100, 300, 1000 or 3000. For this exercise, the DWEL was derived from the lower RfD value
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in each Toxicity Category (See Exhibit 4) and then positioned in the appropriate toxicity and
occurrence cell of the framework.
Since all Toxicity Category 1 contaminants are moved to the PCCL, it is the DWELs for the
Toxicity Category 2 to Toxicity Category 5 groupings that are of interest for this analysis. The
calculated DWELs for the four toxicity categories of interest are as follows:
• Toxicity Category 2-4 |ig/L
• Toxicity Category 3-40 |ig/L
• Toxicity Category 4 - 2,000 |ig/L
• Toxicity Category 5 - 4,000 |ig/L
As shown in Exhibit 10 by the asterisk in the cells, three of the four DWELs fall in the drinking
water concentration range of the first cell that moves to the PCCL. The DWEL for the Toxicity
Category 4 grouping is one unit above the divider. This analysis combined with the positions of
the chemicals in the occurrence test set of chemicals provided support for the position of the
PCCL selection line for finished and ambient water.
Exhibit 10: Criteria for Screening Health Effects and Water Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Finished Water - Concentration (^lg/L)
0-<0.1
0.1-<1
1-<10
*
—
10-<100
*
100-
<1,000
1K-<10K
*
*
>10K
4.2 Environmental Release Data
EPA used total releases to the environment (TRI) and pesticide application rate data to develop
the criteria for this category. To aid in setting the limits for the release category, EPA started
with criteria used to develop the first CCL (CCL 1): that a chemical had to be released in
quantities greater than 400,000 Ibs/yr to surface waters. EPA found that this CCL 1 criterion was
too stringent and only a few chemicals would have moved to the PCCL. Accordingly EPA used
the positions of the test set chemicals to position the Universe to PCCL barrier. The criterion for
moving a chemical with environmental release data to the PCCL is displayed in Exhibit 11.
Chemicals with environmental releases above the non-shaded area move to the PCCL.
Chemicals in the shaded area stay in the Universe.
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Exhibit 11: Criteria for Screening Health Effects and
Environmental Release Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Environmental Release Category -
Total Environmental Releases (Ibs/year)
0-<10
10-
<100
100 -<1K
1K-
<10K
10K-
<100K
100KX1M
1M-
<10M
>10M
II
4.3 Production Data
Similar to the release category, EPA started with the criteria used to develop CCL 1 that a
chemical be produced in quantities greater than 1 billion Ibs/yr. EPA decided that the CCL 1
guideline was too restrictive and proposed criteria that are less stringent for screening at this
stage of the process. The criterion for moving a chemical, with production data, to the PCCL is
displayed in Exhibit 12. Chemicals above the line move to the PCCL. Chemicals in the shaded
areas remain in the CCL Universe.
Exhibit 12: Criteria for Screening Health Effects and
Production Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Production Category (Ibs/year)
<10K
10K-
500K
>500K-
1M
>1M-
10M
>10M-
50M
>50M-
100M
^^
f
>100M-
500M
>500M
-IB
>1B
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4.4 DBFS and Drinking Water Additives
The DBFs and drinking water additives that lacked quantitative occurrence data but fell in the
Toxicity Category 1 or Toxicity Category 2 groupings based on their toxicity were added to the
PCCL because of their high probability for being present in disinfected and treated drinking
water.
5.0 Efficacy of the Framework as a Screening Tool
The proposed screening approach provides a data-driven, objective, and transparent process for
selecting the PCCL from the Universe. Chemicals are screened based on their data elements and
not based on their names or CAS numbers for the initial PCCL screen. All Toxicity Category 1
chemicals are captured no matter what the occurrence data element. The occurrence threshold
required for the PCCL selection become less inclusive as the contaminant toxicity decreases.
Once the initial screening is complete, the names of the PCCL chemicals are apparent. After the
initial screen, quality assurance measures were applied. EPA then conducted a detailed
examination of decisions that placed chemicals close to the borderline.
The screening approach on the CCL 3 Universe selected 561 chemical contaminants from the
approximately 6,000 chemicals in the CCL 3 Universe that were screened. (This includes
contaminant information that was compiled as part of EPA's nominations and surveillance
process and submitted in the public comments on the draft CCL 3.) Appendix 2 shows the
contaminants that moved to the PCCL for additional consideration and the data used in their
screening.
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6.0 References
Health Canada. 2005. What is an LDso and LCso. Canadian Center for Occupational Health and
Safety. Ontario Canada. Available at. http://www.ccohs.ca/oshanswers/chemicals/ld50.html
Hodge, H.C. and J.H. Sterner. 1956. Combined tabulation of toxicity classes. In: Spector, W.S.,
ed. Handbook of toxicology, Philadelphia, W.B. Saunders Company, Vol. 1.
International Toxicity Estimates for Risk (ITER). 2006. ITER Definitions (Classification).
Toxicology Excellence for Risk Assessment, Cincinnati, OH.
Available at: http://www/iter.ctcnet.net/publicurl.glossary.html
National Drinking Water Advisory Committee (NDWAC). 2004. CCL Classification Process.
Report from the NDWAC to the U.S. Environmental Protection Agency Office of Ground Water
and Drinking Water. May 19.
National Toxicology Program (NTP). 2005. Management Status Report Produced from the NTP
Chemtrack System. Central Data Management (EC-03) National Institute of Environmental
Health Services, Research Triangle Park, NC.
USEPA. 1986. United States Environmental Protection Agency. Guidelines for carcinogen risk
assessment. Fed. Reg. 51(185):33992-34003.
USEPA. 2005. United States Environmental Protection Agency. Guidelines for Carcinogen Risk
Assessment. EPA/630/P-03/001B. Risk Assessment Forum, Washington, DC.
USEPA. 2009a. Final Contaminant Candidate List 3 Chemicals: Identifying the Universe. EPA
815-R-09-006. August 2009.
USEPA. 2009b. Final Contaminant Candidate List 3 Chemicals: Classification of PCCL to the
CCL. EPA 815-R-09-008. August 2009.
USEPA. 2009c. Summary of Nominations for the Third Contaminant Candidate List. EPA-815-
R-09-01 I.August 2009.
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7.0 Appendices
Appendix 1. Criteria for Selecting the PCCL
Contains the series of criteria used to select the PCCL from the CCL Chemical Universe.
This criterion is based upon the following hierarchy: Concentrations in Water > Releases to
the Environment > Production
Concentrations in Water
Toxicity Category 1 chemicals with any concentration
Toxicity Category 2 chemicals with concentrations > 1 |j,g/l
Toxicity Category 3 chemicals with concentrations > 10 ng/1
Toxicity Category 4 chemicals with concentrations > 100 |j,g/l
Toxicity Category 5 chemicals with concentrations > 1000 |j,g/l
Releases to the Environment
Toxicity Category 1 chemicals with any amount released
Toxicity Category 2 chemicals with releases/application > 10,000 Ibs/yr
Toxicity Category 3 chemicals with releases/application > 100,000 Ibs/yr
Toxicity Category 4 chemicals with releases/application > 1 M Ibs/yr
Toxicity Category 5 chemicals with releases/application > 10 M Ibs/yr
Production
Toxicity Category 1 chemicals with any amount produced
Toxicity Category 2 chemicals production volumes > 500,000 Ibs/yr
Toxicity Category 3 chemicals with production volumes > 10 M Ibs/yr
Toxicity Category 4 chemicals with production volumes > 50 M Ibs/yr
Toxicity Category 5 chemicals with production volumes > 100 M Ibs/yr
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Appendix 2. Chemicals Passing Screening to the PCCL
The following table in Appendix 2 presents the CASRN, names of the contaminants listed on the
PCCL, and the health effects and occurrence data elements that were used in their screening. The
data elements are described in the text of this report.
For the Health Effects Data Element, Cancer Studies NTP, the Value is shown as the National
Toxicology Program multi-species results (NTPMSR), representing the more detailed criteria
and data used to derive the Toxicity Screening Category. They are described in detail in the text.
For the Occurrence data elements, the Release data may be either national TRI data or pesticide
application data. The notation "FW/AW" indicates the data are finished or ambient water data.
Also noted, for some pesticide degradates, data from the parent compound were used for
screening; for some contaminants supplemental data, compiled in the nominations and
surveillance process were also used.
Further data and information for the contaminants are available on the Contaminant Information
Sheets available in the CCL 3 water docket.
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Appendix 2
CASRN
5989275
100641
630206
918003
79345
75343
119642
87616
96184
95943
95636
122667
106876
106990
542927
77485
542756
99627
99650
105113
1 1 0634
110656
105088
123911
4904614
2432997
57910
81492
71363
112301
1 1 2538
111706
592416
71410
71238
2439352
96139
95954
88062
105679
51285
121142
95807
95874
576261
87627
96297
78897
Common Name
(d)-Limonene
(Hydroxyimino)cyclohexane
1 ,1,1 ,2-Tetrachloroethane
1,1,1 -Trichloropropanone
1,1,2,2-Tetrachloroethane
1,1-Dichloroethane
1 ,2, 3, 4-Tetra hydro naphthalene
1 , 2, 3-Trichloro benzene
1 ,2,3-Trichloropropane
1 ,2,4,5-Tetrachlorobenzene
1 ,2,4-Trimethylbenzene
1 ,2-Diphenylhydrazine
1,2-Epoxy-4-(epoxyethyl)cyclohexane
1,3- Butadiene
1 ,3-Cyclopentadiene
1,3-Dibromo-5,5-dimethylhydantoin
1,3-Dichloropropene
1 ,3-Diisopropylbenzene
1,3-Dinitro benzene
1 ,4-Benzoquinone dioxime
1,4-Butanediol
1,4-Butynediol
1 ,4-Cyclohexanedimethanol
1,4-Dioxane
1 ,5,9-Cyclododecatriene
1 1 -Aminoundecanoic acid
17alpha-estradiol
1-Amino-2,4-dibromoanthraquinone
1-Butanol
1-Decanol
1-Dodecanol
1-Heptanol
1-Hexene
1-Pentanol
1-Propanol
2-(Dimethylamino)ethyl acrylate
2,3-Dibromopropanol
2, 4,5-Trichloro phenol
2, 4,6-Trichloro phenol
2,4-Dimethylphenol
2,4-Dinitrophenol
2,4-Dinitrotoluene
2,4-Toluenediamine
2,5-Xylenol
2,6-Dimethylphenol
2,6-Xylidine
2-Butanone oxime
2-Chloro-1-propanol
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Class
Reference Dose (RfD)
Cancer Classification, EPA
Lethal Dose 50 (LD50)
Tolerable Daily Intake (TDI)
Cancer Studies, NTP
Reference Dose (RfD)
TD50
Risk Specific Dose (RSD)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Acceptable Daily Intake (ADI)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
No Observed Adverse Effect Level (NOAEL)
Cancer Studies, NTP
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Value
NTPMSR
17.9
NTPMSR
LM
0.00005
C
2,860
0.0015
NTPMSR
0.0003
4,350
0.00001
NTPMSR
NTPMSR
113
0.44
NTPMSR
0.25
0.0001
NTPMSR
200
2
1,600
NTPMSR
1,780
NTPMSR
0.00005
NTPMSR
0.2
4,720
1,170
0.0251
1,000
200
600
4
NTPMSR
0.3
NTPMSR
0.02
0.0006
NTPMSR
NTPMSR
383
0.0006
NTPMSR
4
100
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
Toxlclty Screening
Category
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 5
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
1.0
>100M -500M
18
16.97
200
500
>50M-100M
15
3,000
>1M -10M
260
0
10K-500K
1,964,956
>10M -50M
>500K- 1M
39
>1M -10M
528,962
>500K - 1 M
>500M -1B
>100M-500M
>50M -100M
821,067
>50M -100M
>10M-50M
0.074
10K-500K
17,648,846
>50M-100M
>50M -100M
>500K-1M
>500M -1B
>10M-50M
>100M -500M
>10M-50M
10K-500K
18,879
0
168,992
0.0
333
11,834
>10M-50M
>100M -500M
5,256
>10M -50M
>500M-1B
A2-2
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
645625
123057
149575
104767
26266682
103117
7659861
818611
149304
109864
78784
109068
91598
135193
79469
127060
107186
616455
1948330
91941
612828
760236
3401807
132059531
563473
132059519
132059520
16655826
108996
100549
553264
101804
80079
101611
101688
101779
92671
101542
95830
5216251
1 23422
108112
6610293
Common Name
2-Ethyl-3-propylacrolein
2-Ethylhexanal
2-Ethylhexanoic acid
2-Ethylhexanol
2-Ethylhexenal
2-Ethylhexyl acrylate
2-Ethylhexyl thioglycolate
2-Hydroxyethyl acrylate
2-Mercaptobenzothiazole
2-Methoxyethanol
2-Methylbutane
2-Methylpyridine
2-Naphthalenamine
2-Naphthalenol
2-Nitropropane
2-Propanone oxime
2-Propen-1-ol
2-Pyrrolidone
2-tert-Butylhydroquinone
3,3'-Dichlorobenzidine
3,3'-Dimethylbenzidine dihydrochloride
3,4-Dichloro-1-butene
3,6-Dichlorosalicylic acid
3-Bromo-4-(dibromomethyl)-5-hydroxy-2(5H)-
furanone (BMX-3)
3-Chloro-2-methyl-1 -propene
3-Chloro-4-(bromochloromethyl)-5-hydroxy-
2(5H)-furanone(BMX-1)
3-Chloro-4-(dibromomethyl)-5-hydroxy-2(5H)-
furanone (BMX-2)
3-Hydroxycarbofuran
3-Methylpyridine
3-Pyridinecarbonitrile
4,4'-Bipyridine
4,4'-Diaminodiphenyl ether
4,4'-Dichlorodiphenyl sulfone
4,4'-Methylenebis(N,N-
dimethyljbenzenamine
4,4'-Methylenedi(phenyl isocyanate)
4,4'-Methylenedianiline
4-Aminobiphenyl
4-Aminodiphenylamine
4-Chloro-1 ,2-diaminobenzene
4-Chlorobenzotrichloride
4-Hydroxy-4-methyl-2-pentanone
4-Methyl-2-pentanol
4-Methyl-3-thiosemicarbazide
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
TD50
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, EPA
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Maximum Recommended Daily Dose (MRDD)
Risk Specific Dose (RSD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer class only
Cancer Studies, NTP
Cancer class only
Cancer class only
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Classification, EPA
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Value
3,000
2,600
885
2,053
2,005
3
303
300
344
0.001
357.1
0.0099
1
0.437
B2
12.1
0.05
328
0.2
0.000022
NTPMSR
2
3
HM
NTPMSR
HM
HM
7
400
5
172
NTPMSR
0.005
NTPMSR
2,200
4.3
1
150
NTPMSR
B2
30
2,600
14
Units
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
Toxlclty Screening
Category
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
>50M -100M
>50M-100M
>50M -100M
>500M-1B
>100M -500M
>100M-500M
>10M -50M
>10M -50M
644,590
153,774
>1B
27,839
5
>1M - 10M
25,344
>1M -10M
604,872
>10M -50M
>1M - 10M
2
10K-500K
>100M -500M
>10M -50M
0.04
6,635
0.17
0.03
66.3
>10M -50M
>10M-50M
>10M -50M
985
>10M -50M
10K-500K
>100M-500M
168,919
1
>50M-100M
10K-500K
>10M-50M
>100M -500M
>100M-500M
>1M -10M
A2-3
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
98533
100403
95794
16219753
99592
99558
71751412
30560191
75070
79027
60355
103902
64197
108247
34256821
187022113
184992444
67641
75865
75058
107028
79107
107131
1 24049
111693
142363539
171262172
309002
96242
319846
98851
98839
834128
33089611
7664417
1111780
7783188
64285069
62533
142041
100663
50782
492808
86500
741582
Common Name
4-tert-Butylcyclohexanone
4-Vinylcyclohexene
5-Chloro-o-toluidine
5-Ethylidene-2-norbornene
5-Nitro-o-anisidine
5-Nitro-o-toluidine
Abamectin
Acephate
Acetaldehyde
Acetaldehyde, dichloro-Dichloroacetaldehyde
Acetamide
Acetaminophen
Acetic acid
Acetic anhydride
Acetochlor
Acetochlor ethanesulfonic acid (ESA)
Acetochlor oxanilic acid (OA)
Acetone
Acetone cyanohydrin
Acetonitrile
Acrolein
Acrylic acid
Acrylonitrile
Adipicacid
Adiponitrile
Alachlor ethanesulfonic acid (ESA)
Alachlor oxanilic acid (OA)
Aldrin
alpha-Chlorohydrin
alpha-Hexachlorocyclohexane
alpha-Methylbenzenemethanol
alpha-Methylstyrene
Ametryn
Amitraz
Ammonia
Ammonium carbamate
Ammonium thiosulfate
Anatoxin-a
Aniline
Aniline hydrochloride
Anisole
Aspirin
Auramine
Azinphos-methyl
Bensulide
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Effect Level (LOEL)
Cancer Classification, EPA
Cancer Class
TD50
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
TD50
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Cancer Classification, EPA
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Value
5,000
NTPMSR
NTPMSR
4
NTPMSR
NTPMSR
2
0.12
B2
M
180
495
1.47
1,780
0.02
Parent data
Parent data
100
0.0008
0.006
0.0005
53
0.000019
4,000
22
Parent data
Parent data
0.00003
26
0.000002
458
0.07
0.009
0.25
6.2
681
1,098
0.0005
B2
NTPMSR
0.65
0.0021
1
0.91
271
Units
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
Toxlclty Screening
Category
Toxicity Category 5
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 5
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Value
>500M -1B
>1M-10M
10K-500K
>10M-50M
10K-500K
255
14,965
2,467,744
14,683,890
14
1,202,667
10
> 1B
> 1B
30.4
Parent
Parent
1,806
106,961
12,784,367
3.4
6,817,569
7,925,644
> 1B
> 1B
Parent
Parent
4.4
>1M - 10M
0.21
>1B
>100M -500M
446,546
137,397
34,000
> 1B
>50M -100M
Supplemental
937,263
10K-500K
>500K - 1 M
10K-500K
0
3.37
546,600
A2-4
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
25057890
100527
92875
271896
65850
95147
98077
100516
100447
108601
111444
577117
542881
80057
7440428
314409
7726956
108861
83463621
74964
1 09740
85687
25013165
107926
106310
6459945
2429745
28407376
2832408
5160021
842079
471341
1305620
1592230
105602
133062
63252
10605217
75150
120809
75694
75718
302170
1 4866683
Common Name
Bentazon
Benzaldehyde
Benzidine
Benzofuran
Benzoic acid
Benzotriazole
Benzotrichloride
Benzyl alcohol
Benzyl chloride
Bis(2-chloro-1 -methylethyl) ether
Bis(2-chloroethyl) ether
Bis(2-ethylhexyl) sodium sulfosuccinate
Bis(chloromethyl) ether
Bisphenol A -- BPA
Boron
Bromacil
Bromine
Bro mo benzene
Bromochloroacetonitrile (SCAN)
Bromoethane
Butanenitrile
Butyl benzyl phthalate
Butylated hydroxyanisole
Butyric acid
Butyric anhydride
C.I. Acid Red 114, disodium salt
C.I. Direct Blue 15
C.I. Direct Blue 218
C.I. Disperse Yellow 3
C.I. Pigment Red 53, barium salt (2:1)
C.I. Solvent Yellow 14
Calcium carbonate
Calcium hydroxide
Calcium octadecanoate
Caprolactam
Captan
Carbaryl
Carbendazim
Carbon disulfide
Catechol
CFC-11
CFC-12
Chloral hydrate
Chlorate
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
TD50
Risk Specific Dose (RSD)
Cancer Studies, NTP
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Maximum Recommended Daily Dose (MRDD)
Risk Specific Dose (RSD)
Cancer Studies, NTP
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Minimal Risk Level (MRL)
Cancer Classification, EPA
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Cancer class only
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Adverse Effect Level (NOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Minimal Risk Level (MRL)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Adverse Effect Level (NOAEL)
TD50
Cancer Studies, NTP
Value
0.03
1,490
0.000000043
NTPMSR
34
0.60
0.0000008
5
0.00006
NTPMSR
0.0000091
0.5
0.000000045
2.5
0.01
C
440
0.02
M
NTPMSR
28
NTPMSR
0.25
2,000
8,790
NTPMSR
NTPMSR
NTPMSR
NTPMSR
NTPMSR
NTPMSR
60,000
7,300
10,000
50
NTPMSR
0.23
0.59
0.01
84.7
349
15
106
NTPMSR
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 5
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 5
Toxicity Category 5
Toxicity Category 5
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Value
11.46
>10M -50M
83
10K-500K
>100M-500M
>1M -10M
745
>10M -50M
18,750
883
478
>10M -50M
0
12
3,950
57
381,257
40
13.4
>500K - 1 M
>500K- 1M
>50M-100M
1.2
>100M -500M
>100M-500M
10K-500K
>500K - 1 M
2,609
0
>1M -10M
10K-500K
>100M -500M
>100M-500M
>100M -500M
>1B
4,001,523
33.5
>1M -10M
34
35,911
1,444
404.9
92.2
2,234
A2-5
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
1 1 5286
54593838
107200
79049
510156
75003
74873
107302
25167800
76062
126998
1897456
1 04552
77929
110429624
81777891
7440484
91645
1319773
15096523
80159
135206
13752517
21725462
506774
108805
108770
113136779
1 1 0827
108930
108941
108918
68359375
143545908
52315078
66215278
1861321
1163195
541026
6190654
1007289
50997
Common Name
Chlorendic acid
Chlorethoxyfos
Chloroacetaldehyde
Chloroacetyl chloride
Chlorobenzilate
Chloroethane
Chloromethane (Methyl chloride)
Chloromethyl methyl ether
Chlorophenol
Chloropicrin
Chloroprene
Chlorothalonil
Cinnamaldehyde
Citric acid
Clethodim
Clomazone
Cobalt
Cobalt compounds
Coumarin
Cresol
Cryolite
Cumene hydroperoxide
Cupferron
Cure-Rite 18
Cyanazine
Cyanogen chloride
Cyanuric acid
Cyanuric chloride
Cyclanilide
Cyclohexane
Cyclohexanol
Cyclohexanone
Cyclohexylamine
Cyfluthrin
Cylindrospermopsin
Cypermethrin
Cyromazine
Dacthal
Dacthal mono/di-acid degradate
Decabromodiphenyl ether
Decamethylcyclopentasiloxane
Desethylatrazine
Desisopropylatrazine
D-Glucose
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Classification, EPA
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Maximum Recommended Daily Dose (MRDD)
Acceptable Daily Intake (ADI)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Adverse Effect Level (NOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Maximum Recommended Daily Dose (MRDD)
Value
NTPMSR
0.05
36.1
208
NTPMSR
NTPMSR
0.004
A
0.3
32
NTPMSR
NTPMSR
0.21
100
0.01
1,369
0.04
150
13.9
177
23.1
382
NTPMSR
90.8
0.98
0.05
600
350
208
813
1,400
462
11
0.025
0.00003
24.6
0.75
0.01
Parent data
0.01
24,134
Parent data
Parent data
100
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 5
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW
FW/AW
Production Volume (Ibs/year)
Value
0
253,345
2.4
>100M-500M
5
288.2
550
1,085
43,439
13,912,578
925,010
0.71
>1M - 10M
>100M-500M
672,189
2,536,701
684
6,910,811
>1M-10M
1,475,929
2,565,970
443,722
0
>1M -10M
160
20.6
>100M -500M
>100M-500M
177,474
4,761,999
4,538,466
> 1B
>10M-50M
178,171
Supplemental
188,403
14,328
100
190
953,472
>100M-500M
Parent
Parent
>500M-1B
A2-6
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
142223
7398698
333415
3252435
74953
683181
818086
99309
3018120
594047
62737
115322
141662
77736
60571
111422
64675
25340174
111466
112345
111400
68479981
43222486
101906
55290647
60515
868859
112185
77781
120616
124403
75785
753731
25321146
122394
1 42847
25265718
2764729
928723
298044
330541
27176870
2439103
115297
Common Name
Diallyl glycol carbonate
Diallyldimethylammonium chloride
Diazinon
Diazinon oxygen analog
Dibromoacetonitrile (DBAN)
Dibromomethane
Dibutyltin dichloride
Dibutyltin oxide
Dichloran
Dichloroacetonitrile (DCAN)
Dichloroiodo methane
Dichlorvos
Dicofol
Dicrotophos
Dicyclopentadiene
Dieldrin
Diethanolamine
Diethyl sulfate
Diethylbenzene
Diethylene glycol
Diethylene glycol monobutyl ether
Diethylenetriamine
Diethyltoluenediamine
Difenzoquat methyl sulfate
Diglycidyl resorcinol ether
Dimethipin
Dimethoate
Dimethyl hydrogen phosphite
Dimethyl laurylamine
Dimethyl sulfate
Dimethyl terephthalate
Dimethylamine
Dimethyldichlorosilane
Dimethyltin dichloride
Dinitrotoluene
Diphenylamine
Dipropylamine
Dipropylene glycol
Diquat
Disodium iminodiacetate
Disulfoton
Diuron
Dodecylbenzenesulfonic acid
Dodine
Endosulfan
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Acceptable Daily Intake (ADI)
Cancer Class
Cancer Class
Risk Specific Dose (RSD)
TD50
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Classification, IARC
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Value
279
1,000
0.00009
Parent data
NTPMSR
0.01
0.05
0.17
0.01
LM
M
0.00003
32.9
0.0001
0.03
0.00005
20
2A
0.64
1,660
0.01
10
472
206
NTPMSR
0.02
0.0002
NTPMSR
740
2A
NTPMSR
0.347
800
73.9
0.00001
0.83
5
14,850
30
8,070
0.00004
0.63
650
0.004
0.7
Units
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 5
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 5
Toxicity Category 2
Toxicity Category 5
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Value
>10M -50M
>100M -500M
19
Parent
24
21.1
>1M -10M
>1M -10M
189,096
24.6
11
264
788,527
360,513
392,668
5.6
1,396,761
10,644
>10M -50M
>500M -1B
>100M-500M
>100M -500M
>10M -50M
347,066
1
283,076
1,896,947
>1M -10M
>50M-100M
10,221
>1B
618,880
>500M -1B
>10M-50M
6,802
414,131
>10M -50M
>100M-500M
267,442
>500M-1B
3.81
23.3
>100M -500M
151,870
1,604,700
A2-7
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
759944
517099
474862
114078
66230044
50282
140670
50271
53167
64175
16672870
57636
563122
13194484
141786
140885
75047
107211
111762
75218
96457
107153
60004
22224926
13356086
14484641
2164172
144490
72178020
944229
50000
23422539
64186
1 1 0009
98011
96480
7440564
111308
56815
556525
107222
74975
75887
75456
142825
Common Name
EPIC
equilenin
equilin
Erythromycin
Esfenvalerate
Estradiol (17-beta estradiol)
Estragole
Estriol
Estrone
Ethanol
Ethephon
Ethinyl Estradiol (17-alpha ethynyl estradiol)
Ethion
Ethoprop
Ethyl acetate
Ethyl acrylate
Ethylamine
Ethylene glycol
Ethylene glycol monobutyl ether
Ethylene oxide
Ethylene thiourea
Ethylenediamine
Ethylenediaminetetraacetic acid
Fenamiphos
Fenbutatin oxide
Ferbam
Fluometuron
Fluoroacetic acid
Fomesafen
Fonofos
Formaldehyde
Formetanate hydrochloride
Formic acid
Furan
Furfural
gamma-Butyrolactone
Germanium
Glutaraldehyde
Glycerine
Glycidol
Glyoxal
Halon1011
HCFC-133a
HCFC-22
Heptane
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Maximum Recommended Daily Dose (MRDD)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
TD50
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Effect Level (LOEL)
Maximum Recommended Daily Dose (MRDD)
Reference Dose (RfD)
Acceptable Daily Intake (ADI)
Maximum Recommended Daily Dose (MRDD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Tolerable Daily Intake (TDI)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
No Observed Effect Level (NOEL)
TD50
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Maximum Recommended Daily Dose (MRDD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Reference Dose (RfD)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Value
0.025
0.00005
0.00005
66.7
325
0.00005
51.8
0.00005
0.00005
1.43
0.5
0.0005
0.0005
0.0004
25
NTPMSR
400
0.05
5.1
1
0.00008
0.09
30
0.00025
0.03
0.003
0.01
0.47
0.00005
0.2
2.19
18
360
NTPMSR
NTPMSR
160.7
0.32
0.3
999
NTPMSR
200
0.01
87.3
13.5
2,857
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 5
Occurrence Data Element Used For Screening
Occurrence Data Element
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Supp
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Value
40
0.278
0.147
229,386
0.2
>1M -10M
0.051
0.12
> 1B
5,419,825
0.831
505,639
1.95
>100M -500M
152,024
>10M -50M
10,076,483
>100M -500M
374,110
299
>100M-500M
>10M -50M
728,266
265,856
317,819
37.8
>1M -10M
1,102,750
1.2
26,992,234
134,821
10,144,003
>10M -50M
>10M-50M
>50M -100M
225.1
>10M -50M
>100M-500M
10K-500K
>10M -50M
210
56,253
7,075,769
>100M-500M
A2-8
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
87683
67721
471 9044
111499
822060
1 24094
100970
110543
2691410
302012
7647010
6386385
7783064
123319
868779
1 3463406
78831
115117
110190
78820
29590429
121915
78795
67630
625558
75310
6846500
77501634
78977
91465086
1335326
330552
554132
7447418
121755
108316
123331
109773
1 2427382
94746
108394
541731
108781
24307264
Common Name
Hexachlorobutadiene
Hexachloroethane
Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-
triazine
Hexahydroazepine
Hexamethylene-1 ,6-diisocyanate
Hexamethylenediamine
Hexamethylenetetramine
Hexane
HMX
Hydrazine
Hydrochloric acid
Hydrocinnamic acid, 3,5-di-tert-butyl-4-
hydroxy-, methyl ester
Hydrogen sulfide
Hydroquinone
Hydroxyethyl methacrylate
Iron pentacarbonyl
Isobutanol
Isobutene
Isobutyl acetate
Isobutyronitrile
Isooctyl acrylate
Isophthalic acid
Isoprene
Isopropanol
Isopropyl formate
Isopropylamine
Kodaflex txib
Lactofen
Lactonitrile
lambda-Cyhalothrin
Lead acetate
Linuron
Lithium carbonate
Lithium chloride
Malathion
Maleic anhydride
Maleic hydrazide
Malononitrile
Maneb
MCPA
m-Cresol
m-Dichloro benzene
Melamine
Mepiquat chloride
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Classification, EPA
Lowest Observed Effect Level (LOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lowest Observed Effect Level (LOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Classification, EPA
Minimal Risk Level (MRL)
Cancer Studies, NTP
Reference Dose (RfD)
Value
0.0002
NTPMSR
1.99
20.7
350
750
569
0.06
0.99
0.0000033
900
600
0.003
82.8
2.50
12
74.1
NTPMSR
4,763
25
5,000
10,400
NTPMSR
18
1.4
111
30
0.002
31
56
B
0.63
0.017
0.009
0.23
390
500
0.0001
0.005
0.0005
C
0.03
NTPMSR
0.03
Units
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 5
Toxicity Category 5
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
10
1,015
>10M -50M
>1M -10M
>50M-100M
> 1B
>50M-100M
39,844,882
>500K - 1 M
165,485
> 1B
>50M-100M
>1B
574,933
>10M-50M
43,517
>100M-500M
> 1B
>50M-100M
>1M - 10M
>100M-500M
>100M -500M
>100M-500M
> 1B
>1M - 10M
>100M -500M
>50M-100M
390,240
>10M-50M
321,987
>1M -10M
1.4
211,661
10K-500K
9.58
769,446
2,147,846
854,039
3,046,585
18.6
374,903
22.4
>100M-500M
182,976
A2-9
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
68111
150505
72333
79390
79414
126987
10265926
67561
3268493
16752775
59052
79209
96333
74839
598550
74931
80626
1 634044
74895
12108133
93152
4553622
75796
9006422
51218452
171118095
152019733
21087649
101043372
2212671
7439987
1313275
105555
127195
108010
300765
91203
123864
97881
126307
7440020
7440031
139139
98953
Common Name
Mercaptoacetic acid
Merphos
Mestranol
Methacrylamide
Methacrylic acid
Methacrylonitrile
Methamidophos
Methanol
Methional
Methomyl
Methotrexate
Methyl acetate
Methyl acrylate
Methyl bromide (Bromomethane)
Methyl carbamate
Methyl mercaptan
Methyl methacrylate
Methyl tert-butyl ether
Methylamine
Methylcyclopentadienyl manganese
tricarbonyl
Methyleugenol
Methylglutaronitrile
Methyltrichlorosilane
Metiram
Metolachlor
Metolachlor ethanesulfonic acid (ESA)
Metolachlor oxanilic acid (OA)
Metribuzin
Microcystin-LR
Molinate
Molybdenum
Molybdenum trioxide
N.N'-Diethylthiourea
N, N-Dimethylacetamide
N.N-Dimethylethanolamine
Naled
Naphthalene
n-Butyl acetate
N-Butyl methacrylate
Neopentyl glycol
Nickel
Nickel compounds
Niobium
Nitrilotriacetic acid
Nitrobenzene
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Maximum Recommended Daily Dose (MRDD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Tolerable Daily Intake (TDI)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Cancer Classification, EPA
Reference Dose (RfD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Maximum Recommended Daily Dose (MRDD)
Maximum Recommended Daily Dose (MRDD)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Cancer Classification, IARC
Cancer Classification, IARC
Cancer Classification, EPA
Cancer Studies, NTP
Reference Dose (RfD)
Value
114
0.00003
0.00083
451
5
0.0001
0.00005
3.1
1.52
0.1
0.00435
3,705
0.03
0.001
NTPMSR
61
0.36
0.01
100
8
NTPMSR
10
800
0.03
C
Parent data
Parent data
0.62
0.000003
0.2
0.14
NTPMSR
NTPMSR
0.58
15
0.2
NTPMSR
14,000
3.57
100
1
1
A
NTPMSR
0.0005
Units
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 5
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
FW/AW
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Value
>10M -50M
12
0.407
>50M-100M
>100M -500M
89,330
967,698
201,697,278
>100M-500M
3
ND
> 1B
206,487
43
>1M -10M
> 1B
3,657,567
23,000
>50M -100M
>1M - 10M
10K-500K
>10M -50M
>100M-500M
1,388,363
77.6
Parent
Parent
6.61
Supplemental
200
4,733
2,102,324
10K-500K
>10M -50M
>50M-100M
606,781
906
>100M-500M
>10M -50M
>100M-500M
666
34,676,669
>1M -10M
30,679
100
A2-10
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
1836755
55630
75525
872504
924425
55185
62759
924163
621647
86306
10595956
684935
930552
68224
27314132
103651
88733
95498
556672
20325400
528290
88722
95534
636215
19666309
75569
301122
42874033
10028156
72559
4685147
100005
106434
120718
100254
32534819
76017
115775
3296900
110623
14797730
52645531
335671
1763231
77098
101848
Common Name
Nitrofen
Nitroglycerin
Nitro methane
N-Methyl-2-pyrrolidone
N-Methylolacrylamide
N-Nitrosodiethylamine (NDEA)
N-nitrosodimethylamine (NDMA)
N-Nitroso-di-n-butylamine (NDBA)
N-Nitroso-di-n-propylamine (NDPA)
N-Nitrosodiphenylamine
N-Nitrosomethylethylamine (NMEA)
N-Nitroso-N-methylurea
N-nitrosopyrrolidine (NPYR)
Norethindrone (19-Norethisterone)
Norflurazon
n-Propylbenzene
o-Chloronitrobenzene
o-Chlorotoluene
Octamethylcyclotetrasiloxane
o-Dianisidine dihydrochloride
o-Dinitrobenzene
o-Nitrotoluene
o-Toluidine
o-Toluidine hydrochloride
Oxadiazon
Oxirane, methyl-
Oxydemeton-methyl
Oxyfluorfen
Ozone
p.p'-DDE
Paraquat
p-Chloronitrobenzene
p-Chlorotoluene
p-Cresidine
p-Dinitro benzene
Pentabromodiphenyl ethers
Pentachloroethane
Pentaerythritol
Pentaerythritol dibromide
Pentanal
Perchlorate
Permethrin
Perfluorooctanoic acid (PFOA)
Perfluorooctane sulfonic acid (PFOS)
Phenolphthalein
Phenyl ether
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Risk Specific Dose (RSD)
Reference Dose (RfD)
Risk Specific Dose (RSD)
Risk Specific Dose (RSD)
Cancer Studies, NTP
Risk Specific Dose (RSD)
TD50
Risk Specific Dose (RSD)
Maximum Recommended Daily Dose (MRDD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Studies, NTP
Cancer Classification, IARC
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Risk Specific Dose (RSD)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
TD50
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Value
NTPMSR
0.008
NTPMSR
120
NTPMSR
0.00000007
0.000008
0.000002
0.000001
NTPMSR
0.0000004
0.093
0.000005
0.0167
0.04
2.5
0.001
0.02
1,540
NTPMSR
0.0001
NTPMSR
2A
NTPMSR
0.5
0.000042
10
0.3
1.9
0.000029
0.93
473
0.02
NTPMSR
0.0001
0.002
NTPMSR
100
NTPMSR
5.66
0.007
5
1.0
251.0
NTPMSR
2,450
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
Toxlclty Screening
Category
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW
Release (Ibs/yr)
FW/AW
Fails screen
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
25,300
55,979
>10M-50M
6,311,503
12,306
1,000
DBP
5
506
14
DBP
5
DBP
44.0
47
>10M-50M
52.4
>100M-500M
46
105,280
>10M-50M
10,774
22
28,822
433,536
154,565
706,799
715,830
0.062
6,899,701
>10M -50M
22.5
0
28,711
>10M -50M
865
>100M -500M
>1M-10M
>50M -100M
420
1,068,390
Supplemental
10K-500K
10K-500K
>50M-100M
A2-11
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
62384
57410
732116
7723140
88993
110894
156105
99990
26062793
7440097
156434
41198087
1610180
107120
2312358
107197
123386
79094
1639607
57556
107982
108656
57018527
1698608
110861
2176627
14808607
91225
76578126
121824
793248
135988
74051802
7440213
7440235
26628228
532321
7647156
7775099
3926623
128041
25155300
62748
Common Name
Phenylmercury acetate
Phenytoin
Phosmet
Phosphorus
Phthalic acid
Piperidine
p-Nitrosodiphenylamine
p-Nitrotoluene
Poly(dimethyl diallyl ammonium chloride)
Potassium
p-Phenetidine
Profenofos
Prometon
Propanenitrile
Propargite
Propargyl alcohol
Propionaldehyde
Propionic acid
Propoxyphene hydrochloride
Propylene glycol
Propylene glycol 1 -methyl ether
Propylene glycol monomethyl ether acetate
Propylene glycol mono-t-butyl ether
Pyrazon
Pyridine
Pyridine, pentachloro-
Quartz (SiO2)
Quinoline
Quizalofop
RDX (Hexahydro-1 ,3,5-trinitro-1 ,3,5-triazine)
Santoflex 13
sec-Butylbenzene
Sethoxydim
Silicon
Sodium
Sodium azide
Sodium benzoate
Sodium bromide
Sodium chlorate
Sodium chloroacetate
Sodium dimethyldithiocarbamate
Sodium dodecylbenzenesulfonate
Sodium fluoroacetate
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
TD50
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Cancer Classification, DSSTOX
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Classification, IARC
Risk Specific Dose (RSD)
Reference Dose (RfD)
Risk Specific Dose (RSD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Value
0.00008
59.1
26
0.00002
0.56
22.4
NTPMSR
0.01
290
0.94
0.24
0.05
0.015
35.8
0.02
20
LM
1,640
0.0013
5
0.7
300
NTPMSR
493
NTPMSR
435
1
0.0000033
Surrogate data
0.00009
6
4.42
8.9
3,160
9.4
0.25
1,600
0.13
1.4
95
300
438
0.00002
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 5
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
>1M -10M
15,981
1,336,387
52,750
>1M - 10M
>1M -10M
0
>10M-50M
>50M -100M
23,955
>1M - 10M
881,702
40
>10M -50M
20
64,096
699,803
>100M -500M
10K-500K
>1B
>100M -500M
>50M-100M
>1M-10M
118,553
1,302,842
>10M -50M
10K-500K
28,629
341,564
>1M - 10M
>50M -100M
22
1,721,030
98,916
1,541,000
66,425
>50M -100M
>1M - 10M
7,277,453
>10M -50M
129,318
>50M -100M
0
A2-12
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
7681529
137428
1313822
13718268
50704
131929607
57114
7440246
7782992
2699798
35400432
1934210
107534963
112410238
34014181
1 3494809
13071799
56070167
56070156
100210
75650
75912
75649
98066
78002
1 1 61 43
109999
75570
75592
64028
25265774
79277671
2231574
59669260
23564058
108985
137268
7440291
26471625
66841256
75967
78488
1461229
545062
Common Name
Sodium hypochlorite
Sodium methyldithiocarbamate
Sodium sulfide
Sodium vanadate
Sorbitol
Spinosyn A
Stearic acid
Strontium
Sulfurous acid
Sulfuryl fluoride
Sulprofos
fartrazine
febuconazole
febufenozide
febuthiuron
Tellurium
ferbufos
ferbufos sulfone
ferbufos-O-analogue sulfone
ferephthalic acid
tert-Butanol
tert-Butyl hydroperoxide
tert-Butylamine
tert-Butylbenzene
fetraethyl lead
fetrafluoroethene
fetrahydrofuran
retramethylammonium chloride
retramethylammonium hydroxide
fetrasodium EDTA
fexanol
fhifensulfuron
fhiocarbazide
fhiodicarb
fhiophanate-methyl
fhiophenol
fhiram
rhorium-232
Toluene diisocyanate
fralomethrin
fribromoacetic Acid (TBAA)
fribufos
fributyltin chloride
frichloroacetonitrile
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Maximum Recommended Daily Dose (MRDD)
Acceptable Daily Intake (ADI)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Classification, EPA
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Cancer Class
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Cancer Class
Value
2.2
50
205
0.62
833
0.02
1,490.5
190
0.5
100
0.6
0.014
0.03
0.02
7
20
0.000025
Parent data
Parent data
142.5
64.6
320
44
4.42
0.0000001
NTPMSR
NTPMSR
50
34
2,000
3,200
Surrogate data
6
0.03
8
0.00001
0.005
A
NTPMSR
0.75
LM
0.00003
0.03
LM
Units
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 5
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Value
>10M -50M
60,154,489
>100M-500M
>1M - 10M
>50M-100M
117,572
>100M-500M
43,550
>1M - 10M
142,720
308,713
>1M - 10M
479,616
104,642
17.3
365.4
0.56
Surrogate
0.016
> 1B
1,548,617
>10M -50M
>10M -50M
77.5
>1M-10M
>50M -100M
1,430
>10M -50M
>10M -50M
>100M -500M
>100M -500M
105,375
>1M - 10M
823,065
454,785
10K-500K
180,203
61.7
129,143
23,819
19
4,929,032
>1M - 10M
41.54
A2-13
-------
EPA-OGWDW
Final CCL 3 Chemicals:
Screening to a PCCL
EPA815-R-09-007
August 2009
Appendix 2
CASRN
102716
121448
1 1 2276
1582098
552307
512561
75503
77996
118967
101020
76879
126727
140089
1 1 5968
1120214
57136
51796
7440622
1314621
1929777
50471448
108054
75025
25013154
137304
Common Name
friethanolamine
friethylamine
friethylene glycol
frifluralin
frimellitic anhydride
frimethyl phosphate
frimethylamine
frimethylolpropane
Trinitrotoluene
friphenyl phosphite
friphenyltin hydroxide (TPTH)
rris(2,3-dibromopropyl) phosphate
fris(2-chloroethyl) phosphite
fris(chloroethyl)phosphate
Undecane
Urea
Urethane
Vanadium
Vanadium pentoxide
Vernolate
Vinclozolin
Vinyl acetate
Vinyl fluoride
Vinyltoluene
Ziram
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
TD50
Cancer Classification, IARC
Reference Dose (RfD)
TD50
Value
100
1
3.6
0.75
1,900
NTPMSR
397
0.05
0.0005
444
0.0005
NTPMSR
100
NTPMSR
100
200
16.9
0.007
NTPMSR
0.001
0.025
341
2A
0.006
10.7
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
Toxlclty Screening
Category
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
>100M -500M
1,167,219
>100M -500M
1.74
>100M-500M
10K-500K
>50M -100M
>50M-100M
>1M-10M
>10M -50M
662,418
500
>10M -50M
0.20
>100M-500M
> 1B
96,050
70.4
>1M-10M
182,187
122,226
3,068,589
>1M-10M
>10M -50M
1,996,914
A2-14
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