vvEPA
United States
Environmental Protection
Agency
Contaminant Information Sheets for the
Final CCL 3 Chemicals
-------
Office of Water (4607M)
EPA815-R-09-012
August 2009
www.epa.gov/safewater
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EPA815-R-09-012 Final CCL 3 Chemicals August 2009
EPAOGWDW Contaminant Information Sheets Page 1 of 214
Contaminant Information Sheets for the Final CCL 3 Chemicals
This File contains Contaminant Information Sheets for 106 chemical contaminants that are listed
on the final third Contaminant Candidate List (CCL 3). (Note: there are 104 chemical entries
listed in the Federal Register Notice for the final CCL 3; cyanotoxins are listed as a group. In this
file, there are information sheets on three individual cyanotoxins that were evaluated in the CCL
3 process (Anatoxin-a, Cylindrospermopsin, and Microcystin-LR)). These sheets summarize
information about the chemicals that were considered during the development of the CCL 3. The
sheets are in alphabetical order. Each information sheet is two pages in length. There is an
index/bookmark in this PDF file that can be used to negotiate the file. The bookmarks are
hyperlinked. You can find the contaminant name in the bookmark list, click on it, and the
hyperlink will take you to that file.
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EPA815-R-09-012 Final CCL 3 Chemicals August 2009
EPA OGWDW Contaminant Information Sheets Page 2 of 214
This page intentionally left blank for double-sided printing
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1,1,1,2-Tetrachloroethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 3 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,1,1 ,2-Tetrachloroethane
9105
630206
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.03
0.03
0.03
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
2006
Critical Effect
Mineralization of the kidneys in males, hepatic clear cell
change in females
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.1
0.026
C
3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1989
1989
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
1
210
1
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude , „
36 L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 67.7
CAR HRL/NCOD R1 90%: 0.323
Notes
Reference Dose
Reference Dose; Basis LOAEL = 89.3 mg/kg-d (NTP 1983)
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
EPA; RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLswere calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.
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1,1,1,2-Tetrachloroethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 4 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
16,956
24,127
31
51
0.18
0.21
0.06
0.2
9.2
18
0.59
0.5
3.1
1.55
9.2
18
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309
Amount
Released
36
12,088
# PWSs/Sites
sampled
4
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.09
Number of
States
2
7
% PWSs/Sites
with detects
0.011
Units
States
States
States
Minimum value of
Detects
Non-cancer: 67.7
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.0644
Year
2004
2004
Maximum
value of
Detects
0.0275
0.0644
0.0644
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer: 0.323
Notes
Chemical intermed ate (NTP)
Value
60
93-399
2.66
2.70E-03
1,100
22
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
PBT; BST = biodegrades sometimes/recalcitrant
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1,1-Dichloroethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 5 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
1,1-Dichloroethane
2647
75343
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.2
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
Critical Effect
Decreased body weight gain
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0057
C
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1990
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
1,400
6.14
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
77 Li
HRL Ratio(s)
NC HRL/NCOD R1 90%: 250
CAR HRL/NCOD R1 90%: 1.1
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; basis NOAEL 71 4 mg/kg-d, UF = 3,000; Muralidhara, et al, 2001 .
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
OEHHA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
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1,1-Dichloroethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 6 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
20,483
24,808
233
184
1.14
0.74
0.01
0.0013
500
159
1.2
1
5.6
3.8
27
25
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,350
Amount
Released
63
17,368
# PWSs/Sites
sampled
135
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
3.103
Number of
States
3
5
% PWSs/Sites
with detects
0.008
Units
States
States
States
Minimum value of
Detects
Non-cancer: 250
Amount Range
>1M-10M
>500K - 1 M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
39
Year
2004
2004
Maximum
value of
Detects
0.05
0.316
5.6
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer: 1.1
Notes
Solvent (NTP)
Value
38
30
1.79
5.62E-03
5040
46
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = Biodegrades Slowly with Acclimation
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1,2,3-Trichloropropane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 7 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1 ,2,3-Trichloropropane
3817
96184
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.006
0.006
0.006
0.06
5.71
22.9
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
2006
1992
1987
Critical Effect
Alterations in clinical chemistry & reduction in RBC mass
Hepatic
Kidney, Ureter, Bladder - changes in bladder weight, Blood
- changes in serum composition (e.g. TP, bilirubin,
cholesterol), Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - other esterases
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
7
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.2
42
0.005
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude
3 6 Li
HRL Ratio(s)
NC HRL/NCOD R2 90%: 2.1
CAR HRL/NCOD R2 90% : 0.00025
Notes
Reference Dose
Reference Dose; NTP, 1983 ; rats; UF = 1,000; Basis NOAEL = 8 mg/kg-d
Reference Dose; F' 89
Reference Dose
Minimal Risk Level; Int-MRL; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; ITER NOAEL
Lowest Observed Adverse Effect Level; 1 7 week oral study in rats; NTPTR National Toxicology Program
Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-
TR-384,1993
Supplemental Data
HEAST
CACART, RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
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1,2,3-Trichloropropane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 8 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
17,392
24,088
44
19
0.25
0.079
0.1
0.03
112
3,000
0.92
0.5
6
20
112
3,000
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
4,309
Amount
Released
282
9,053
43
Units
Ibs/yr
Ibs/yr
Ibs/yr
1.0
Number of
States
1
2
0.05
Units
States
States
States
2.92
Year
2004
2004
0.4
0.97
2.92
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
Nominated data from NJDEP
HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
NJ study: Detected in excess of health-based drinking water guidance value in 30 of 2,640 private wells and 11 of approximately 260 community
water systems between 1999 and 2004 in NJ SOC Waiver Program sampling.
Non-cancer: 2.1
Amount Range
>10M-50M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.00025
Notes
Paint ingredient (NTP)
Value
38
77-95
2.27
3.43E-04
1,750
25
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
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1,3-Butadiene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 9 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,3-Butadiene
4578
106990
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude
10 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
3.4
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-'
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.0103
Y/N
Y/N
ug/L
ug/L
Teratogen List
3-model Categorical Prediction
L
HRL Ratio(s)
No Water Data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Vol.71; 1999
EPA, IARC, CACART, OEHHA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
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1,3-Butadiene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 10 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
493
1,964,956
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
8
34
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Rubber chemical (NTP)
Value
7-28
288
1.99
7.40E-02
735
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = biodegrades fast with acclimation
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1,3-Dinitrobenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 11 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,3-Dinitrobenzene
4045
99650
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0001
0.0001
0.0001
0.0005
1.73
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1988
2006
1995
Critical Effect
Increased spleen weight
Hemato.
Endocrine - changes in spleen weight, Blood -
methemoglobinemia-carboxyhemoglobin
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1991
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.005
0.7
Y/N
Y/N
mg/L
ug/L
ug/L
2006
male
Prevalence Magnitude
1 8 NLi
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; Cody etal., 1981; Rats; UF = 3,000; Basis NOAEL = 0.4 mg/kg-d
Reference Dose
Reference Dose; IRIS
Minimal Risk Level; Int-MRL; UF = 1 ,000
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90 day oral study in rats; TOXID9 Toxicologist. (Soc. of
Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year
30,200,1996
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
1,3-Dinitrobenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 12 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
2
528,962
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
1
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
ndustrial chemical (HSDB)
Value
38
150
1.49
4.90E-08
533
37
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
-------
1,4-Dioxane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 13 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,4-Dioxane
5539
123911
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.1
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.3
0.011
0.027
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1999
1987
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
700
3
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
9 8 L
HRL Ratio(s)
NC HRL/CAL DHS 90%: 92.1
CAR HRL/CAL DHS 90%: 0.395
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; ATSDR MRL-int = 0.6 mg/kg-d
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART; EPA; IARC; OEHHA; RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
1,4-Dioxane
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 14 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental water data
CAL DHS
HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
89,521
821,067
n
PWSs/Sites/Sa
mples
869
Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
89
Number of
States
7
22
%
PWSs/Sites/Sam
pies with
detects
10.2
Units
States
States
States
Minimum value of
Detects
0.001
Non-cancer: 92.1
Amount Range
>1M-10M
>1M-10M
Solvent (NTP); so
Value
1
-0.27
4.80E-06
1,000,000
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
46.2
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
2.1
90% of
Detects
7.6
Units
ug/L
Cancer: 0.395
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
vent stabilizer
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
BS = biodegrades slowly
-------
17 alpha-Estradiol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 15 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
17 alpha-Estradio
81747
57910
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
9 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormonal response in post-menopausal
women
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
3-model Categorical Prediction
L?
HRL Ratio(s)
NC HRL/Kolpin MAX: 4.7
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
17 alpha-Estradiol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 16 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, et al., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
5.7
Units
States
States
States
Minimum value of
Detects
Non-cancer: 4.7
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.074
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.03
90% of
Detects
Units for Mag
data
ug/L
Notes
National Surface Water Reconnaissance
Kolpin, D.W., et al., 2002. Env. Sci. STechnol., 36(6), pp. 1202-1211.
Cancer:
Pharmaceutical, hormone
Value
38
3.94
3.9
11
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slowly with acclimation
-------
1-Butanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 17 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
1-Butanol
2563
71363
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.1
0.1
0.2
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
Critical Effect
Hypoactivity, ataxia
Behavioral - somnolence (general depressed activity)
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1991
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
700
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude , „ ,
10 10 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; U.S. EPA, 1986; Basis NOAEL = 125 mg/kg-d, UF = 1,000; oral study in rats.
Reference Dose
Reference Dose; IRIS
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30 day oral study in rats; TOLED5 Toxicology Letters. (Elsevier
Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year
135,3122,2002
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
1-Butanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 18 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
22,011
17,648,846
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
20
44
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Paint solvent; chemical intermediate; food additive (HSDB)
Value
2.443
0.88
8.82E-06
63200
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades Fast
-------
2-Methoxyethanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 19 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
2-Methoxyethanol
4803
109864
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.003
Units
mg/kg-d
mg/kg-d
mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Reproductive effects
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
21
Y/N
Y/N
ug/L
ug/L
Teratogen / developmental, male
Prevalence Magnitude
9 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Unpublished NTP study - Gulati, et al, 1990.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
UMD / CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
2-Methoxyethanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 20 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
14,390
153,774
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
3
16
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>10M-50M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Consumer products; synthetic Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin Lot on (NTP)
Value
1
-0.77
3.30E-07
1000000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = Biodegrades Fast with acclimat on
-------
2-Propen-1-ol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 21 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
2-Propen-1-ol
4596
107186
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.005
0.005
2.5
52
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
Critical Effect
Impaired renal function & increased relative liver,
spleen & kidney weights
Liver - liver function tests impaired, Blood - changes in
serum composition (e.g. TP, bilirubin, cholesterol),
Biochemical - Metabolism (Intermediary) - Plasma proteins
not involvinq coaqulation
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
35
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
8 8 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; Carpanini et al., 1978; Rat; UF = 1,000; Basis NOAEL = 4.8 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; Rat; VCVGK "Vrednie chemichescie veshestva, galogen I
kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,121,1994
Supplemental Data
Rabbit; NTIS National Technical Information Serv ce. (Springfield, VA 22161) Formerly U.S.
Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0571508
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
2-Propen-1-ol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 22 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
10,971
604,872
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
4
13
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Manufacture of flavorings, perfumes; chemical intermediate (HSDB)
Value
1.325
0.17
5.00E-06
1,000,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
3-Hydroxycarbofuran
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 23 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
3-Hydroxycarbofuran
25541
16655826
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00006
7
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Inhibition of brain cholinesterase in pups - The RfD for
the parent covers the toxicity of the metabolite
Decreased body wt.
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.42
Y/N
Y/N
W/L
W/L
Prevalence Magnitude
2 7 Li
HRL Ratio(s)
NC HRL/NCOD R2 90%: 0.191
Notes
Reference Dose; Basis = BMDL10 0.03 mg/kg-d; UF = 500.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
PCBPBS Pesticde Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1971- Volume(issue)/page/year 3,435,1973
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
3-Hydroxycarbofuran
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 24 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
12,700
18
0.14
1
66.3
2.2
2.2
66.3
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,539
Amount
Released
n
PWSs/Sites/Sa
mples
1
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
1
0.022
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0
0.4
0.07
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.191
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.07
Year
Maximum
value of
Detects
0
0.062
0.07
0.07
0.07
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Pesticide degradate
Value
38
43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = Biodegrades Slowly with Acclimation
-------
4,4'-Methylenedianiline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 25 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
4,4'-Methylenedianiline
4202
101779
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.08
4.34
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1998
Critical Effect
ntense liver degenerative lesions, hyperplasia of the
stroma
Liver - fatty liver degeneration, Kidney, Ureter, Bladder -
interstitial nephritis, Blood - normocytic anemia
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.25
1.6
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
560
0.022
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,
7 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1 5 week oral study in dogs; JJATDK JAT, Journal of Applied
Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year 11,367,1991
Supplemental Data
Slope factor withdrawn
Vol. 39, Suppl. 7; 1987
IARC, CACART, OEHHA, RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
4,4'-Methylenedianiline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 26 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
96,446
168,919
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
2
10
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical intermed ate; corrosion nhibitor; curing agent for polyurethanes (HSDB)
Value
4,950
1.59
1.58E-11
1,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
-------
Acephate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 27 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acephate
31325
30560191
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0012
0.004
0.004
0.03
10
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1989
1990
Critical Effect
Brain ChE inhibition
Brain and Coverings - other degeneratve changes,
Autonomic Nervous System - sympathomimetic,
Biochemical - Metabolism (Intermediary) - amino acids
(including renal excretion)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.4
0.0087
C
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
1988
Liver
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
8.4
4
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 7 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 1.17
CAR HRL/SWC EEC: 0.556
Notes
Reference Dose; Basis = NOAEL 0.12 mg/kg-d; UF = 100.
Reference Dose; Basis = LOEL females = 0.15 mg/kg-d; LOEL males = 0.12 mg/kg-d; Adjusted Basis
Value = LOAEL 0.0004 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; ENVRAL Environmental Research. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1967- Volume(ssue)/page/year 43,342,1987
Supplemental Data
EPA; RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Acephate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 28 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
2,462,354
0
20,751
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
35
0
5
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 7.2 ug/L
Ground water chronic: 0.02 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.17
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.556
nsecticide (HSDB)
Value
21.8
-0.85
5.02E-13
818,000
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
Acetaldehyde
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 29 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Acetaldehyde
2622
75070
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
10
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Behavioral - changes in motoractivity (specific assay)
Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/DBP ICR MED: 3.15
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield,
VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issueXpage/year PB234-882; 22-wk guinea pig study
Supplemental Data
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
1988
1999
Vol. 36, Suppl. 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative
cancer risk data were identified for potency scoring.
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
23.3
Y/N
Y/N
ug/L
ug/L
Teratogen list
IARC, EPA, CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Acetaldehyde
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 30 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
DBF ICR
# PWSs/Sites
sampled
236
#with Detects
27
% PWSs/Sites
with detects
11.44
Minimum value of
Detects
Maximum
value of
Detects
18.3
Median value of
Detects
T.4
Mean value of
Detects
8.04
Units for Mag
data
ug/L
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
HRL Ratios (HRL/DBP ICR MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
# Sam pies
Amount
Released
370,815
14,683,890
n
PWSs/Sites/Sa
mples
8
#with Detects
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
3
% Samples with
detects
Number of
States
31
38
%
PWSs/Sites/Sam
pies with
detects
37.5
Minimum value of
Detects
Units
States
States
States
Minimum value of
Detects
1
Non-cancer: 3.15
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Maximum
value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
24
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag
data
ug/L
ug/L
ug/L
Notes
Notes
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes
Median value of
Detects
2
90% of
Detects
4
Units for Mag
data
ug/L
Cancer:
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Pesticide; food additive; chemica intermediate (HSDB)
Value
1.498
-0.34
6.68E-05
1,000,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades fast (BIODEG)
-------
Acetamide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 31 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetamide
2411
60355
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
o.or
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-'
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.5
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
7 9 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART; OEHHA; IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Acetamide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 32 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
2,754
1,202,667
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
3
7
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Solvent; solubilizer; plasticizer; stabilizer (HSDB)
Value
5
-1.26
1.21E-08
2,250,000
39
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BF
Notes
BF = biodegrades fast
-------
Acetochlor
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 33 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor
32393
34256821
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.02
0.02
5.45
Units
mg/kg-d
mg*g-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1993
Critical Effect
Salivation, increased ALT & omithine carbamyl
transferase; increases in triglyceride & decreased blood
glucose levels; histopathological changes in kidneys &
testes
Brain and Coverings - other degenerative changes, Blood -
methemoglobinemia-carboxyhemoglobin, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - dehvdroaenases
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
140
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NC HRL/NAWQ 90% : 179
Notes
Reference Dose
Reference Dose; Basis NOAEL 2 mg*g-d; UF = 100. ICI, Inc., 1988a
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 42-day study in rat; PRKHDK Problemi na Khigienata. Problems in
Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, PI. Slaveikov 11, Sofia, Bulgaria) V.1- 1975-
Volume(issue)/page/year 15,96,1990
Supplemental Data
CACART
Drinking Water Equ valent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Acetochlor
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 34 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615
0
0
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529
Amount
Released
32,591,175
n
PWSs/Sites/Sa
mples
n
PWSs/Sites/Sa
mples
1,872
848
278
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
115
69
#with Detects
0
293
5.02
Number of
States
35
%
PWSs/Sites/Sam
pies with
detects
35.6
30.3
%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011
Units
States
States
States
Minimum value of
Detects
Minimum value of
Detects
0.026
Non-cancer: 179
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
30.4
Year
1997
Maximum value
of Detects
0.334
0.395
Maximum value
of Detects
21
0.032
0.784
8.49
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.022
95% of Detects
0.002
0.061
90% of Detects
1.5
Units
ug/L
ug/L
Units
ug/L
ug/L
Cancer:
Notes
Pesticide Pilot Mentoring Program (USGS/EPA)
Notes
Drinking water monitoring; http://www.cdph.ca.gov/certlic/
drinkingwater/Pages/Chemicalcontaminants.aspx
Herbicide (HSDB)
Value
4.3
98.5-239
3.03
5.4E-11
233
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast (half-life is for soil)
-------
Acetochlor ESA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 35 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor ethanesulfonic acid (ESA)
79191
187022113
Attribute Scores
Potency Severity
5 3
Prevalence Magnitude
1 1
Scores based on parent
HEALTH EFFECTS DATA1 - See Acetochlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
23
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Reduced body weights and body weight gains in both
sexes
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
161
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 205 (NAWQA data for acetochlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Acetochlor ESA
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 36 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data - FOR ACETOCHLOR - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615
0
0
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data - FOR ACETOCHLOR - PARENT
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ACETOCHLOR ESA
POP finished water
FOR ACETOCHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529
Amount
Released
32,591,175
n
PWSs/Sites/Sa
mples
377
n
PWSs/Sites/Sa
mples
1,872
848
278
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
5
#with Detects
0
293
5.020
Number of
States
35
%
PWSs/Sites/Sam
pies with
detects
1.3
%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011
Units
States
States
States
Minimum value of
Detects
0.02
Minimum value of
Detects
0.026
Non-cancer: 205
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
30.4
Year
1997
Maximum value
of Detects
0.02
Maximum value
of Detects
21
0.032
0.784
8.49
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
FOR ACETOCHLOR - PARENT
Median value of
Detects
Median value of
Detects
0.022
95% of Detects
90% of Detects
1.5
Units
ug/L
Units
ug/L
ug/L
Cancer:
Notes
Pesticide Data Program (USD A); 2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx
NAWQA data for acetochlor - parent
Pesticide degradate
Value
Units
length of time
Ukg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Acetochlor OA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 37 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor oxani ic acid (OA)
79193
194992444
Attribute Scores
Potency Severity
5 3
Prevalence Magnitude
1 1
Scores based on parent
HEALTH EFFECTS DATA1 - See Acetochlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
23
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Reduced body weights and body weight gains in both
sexes
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
161
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 205 (NAWQA data for acetochlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR OA
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.
-------
Acetochlor OA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 38 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data FOR ACETOCHLOR - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615
0
0
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data FOR ACETOCHLOR - PARENT
N AWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
FRI Release - surface water
TRI Release - total
Supplemental wate data FOR
ACETOCHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
r,72, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529
Amount
Released
32,591,175
n
PWSs/Sites/Sa
mples
1,872
848
278
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
293
5.02
Number of
States
35
%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011
Units
States
States
States
Minimum value of
Detects
0.026
Non-cancer: 205
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
30.4
Year
1997
Maximum value
of Detects
21
0.032
0.784
8.49
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
FOR ACETOCHLOR - PARENT
Median value of
Detects
0.022
90% of Detects
1.5
Units
ug/L
ug/L
Cancer:
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
NAWQA data for acetochlor - parent
Pesticide degradate
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Acrolein
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 39 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acrolein
4581
107028
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0005
0.0005
0.0005
0.5
Units
mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2003
12/1990
Critical Effect
Decreased survival
Hemato.
Liver - liver function tests impaired, Kidney, Ureter,
Bladder - other changes
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1995
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
3.5
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
3 7 Li L
HRL Ratio(s)
NC HRL/NAWQA 90% : 1 .03
Notes
Reference Dose
Reference Dose; Basis = NOAEL 0.05 mg/kg-d; UF = 100. Parent, et. al, 1S92a
Reference Dose
Reference Dose (IRIS)
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26-week study in rat; VCVGK "Vrednie chemichescie veshestva,
galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,385,1994
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Acrolein
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 40 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
1,108
Amount
Released
1
284,480
# PWSs/Sites
sampled
2
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.18
Number of
States
1
16
% PWSs/Sites
with detects
1.3
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.03
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
3.4
Year
2004
2004
Maximum
value of
Detects
2.35
3.4
3.4
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Aquatic herbicide; rodenticide; industrial chemical (HSDB)
Value
120-180
3
-0.01
1.22E-04
212,000
Units
hours in water
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BF
Notes
pH = 7; BF = biodegradesfast
-------
Alachlor ESA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 41 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Alachlor ethanesulfonic acid (ESA)
71246
142363539
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
157
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
ncreased incidence of clinical signs of toxicity in
males and females and decreased body weight gains
in males.
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
0.04
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
1,100
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,,,
93 NL
Scores based on parent HRL Ratio(s)
NC HRL/NAWQA 90% : 4,300 (NAWQA data for
alachlor - parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP - FOR ALACHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data
FOR ALACHLOR - PARENT
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.
-------
Alachlor ESA
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 42 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data - FOR ALACHLOR PARENT
NAWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ALACHLOR ESA
POP finished water
POP finished water
FOR ALACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,166
Amount
Released
n
PWSs/Sites/Sa
mples
79
233
n
PWSs/Sites/Sa
mples
8,112
2,111
568
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
3
76
#with Detects
3
361
7.9
Number of
States
%
PWSs/Sites/Sam
pies with
detects
3.8
32.6
%
PWSs/Sites/Sam
pies with
detects
0.0003
17.1
0.0008
Units
States
States
States
Minimum value of
Detects
0.50
0.02
Minimum value of
Detects
0.24
0.0125
Non-cancer: 4,300
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
38.2
Year
Maximum
value of
Detects
0.50
1.44
Maximum
value of
Detects
14
10.78
0.015
0.256
3.33
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
4.29
0.06
95% of
Detects
90% of
Detects
11.09
0.55
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Pesticide Data Program (USD A); 2001
2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminant
s.aspx
NAWQA data for alachlor - parent
Pesticide degradate
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
AlachlorOA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 43 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Alachlor oxanilic acid (OA)
79196
171262172
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
Scores based on parent
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.04
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.4
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
93 Li
Scores based on parent HRL Ratio(s)
CAR HRL/NAWQA 90% : 1 .56 (NAWQA data for
alachlor- parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
FOR ALACHLOR - PARENT
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
AlachlorOA
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 44 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data - FOR ALACHLOR PARENT
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ALACHLOR OA
POP finished water
POP finished water
FOR ALACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,166
Amount
Released
n
PWSs/Sites/Sa
mples
137
411
n
PWSs/Sites/Sa
mples
8,112
2,111
568
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
21
#with Detects
3
361
r.9
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0.07
5.1
%
PWSs/Sites/Sam
pies with
detects
0.0003
17.1
0.0008
Units
States
States
States
Minimum value of
Detects
0.50
0.121
Minimum value of
Detects
0.24
0.0125
Non-cancer:
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
38.2
Year
Maximum
value of
Detects
0.50
0.392
Maximum
value of
Detects
14
10.8
0.015
0.256
3.33
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Median value of
Detects
4.29
0.06
95% of
Detects
90% of
Detects
11.09
0.55
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer: 1.56
Notes
Pesticide Data Program (USDA); 2001
2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
NAWQA data for alachlor - parent
Pesticide degradate
Value
Units
ength of time
Ukg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
alpha-Hexachlorocyclohexane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 45 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
alpha-Hexachlorocyclohexane
6535
319846
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.008
1.2
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
9/2003
Critical Effect
Hepatic
Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - hepatic microsomal mixed oxidase
(dealkylation, hydroxylation, etc.), Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels -
catalases, Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - other oxidoreductases
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0006
6.3
2.7
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
56
0.006
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
4 3 Li
HRL Ratio(s)
NC HRL/NAWQA 90% : 949
CAR HRL/NAWQA 90%: 0.102
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; Basis NOAEL 0.8 mg/kg-d; UF = 1 00.
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-day study in rat; TOLED5 Toxicology Letters. (Elsevier
Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year
56,137,1991
Supplemental Data
IRIS
EPA; RAIS; OEHHA; IARC
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
alpha-Hexachlorocyclohexane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 46 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,113
Amount
Released
# PWSs/Sites
sampled
21
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.295
Number of
States
% PWSs/Sites
with detects
0.0004
Units
States
States
States
Minimum value of
Detects
Non-cancer: 949
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.21
Year
Maximum
value of
Detects
0.011
0.059
0.21
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer: 0.102
Notes
Component of benzene hexachloride (BHC) former insecticide (HSDB)
Value
1.2
641-1,995
3.8
6.70E-06
2
Units
years
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BST
Notes
hydrolysis only, pH = 7; BST = biodegrades sometimes/reca citrant
-------
Anatoxin-a
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 47 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Anatoxin-a
80772
64285069
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Mortality
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
3.5
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
9 8 L
Scores based on supplemental data HRL Ratio(s)
NC HRL/Cyano HABs MAX: -0.35
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis NOAEL 0.5 mg/kg-d. Astrachan, N.B. and B.G. Archer. 1981.
Simplified monitoring of anatoxin-a by reverse-phase high performance liquid chromatography
and the sub-acute effects of anatoxin-a in rats. In: The Water Environment: Algal Toxins and
Health, W.W. Carmichael, Ed. Plenum Press, New York, NY. p. 437-446. Astrachan, N.B., B.G,
Archer and D.R. Hilbelink. 1980, Evaluation of thesubacutetoxicity and teratogenicity of anatoxin-
a. Toxicon. 18(5-6): 684-688.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Anatoxin-a
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 48 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Prev: UCMR1 Meeting summary; Mag:
CyanoHABs - The Florida Experience
HRL Ratios (HRL/CyanoHABs MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
4
Units
States
States
States
Minimum value of
Detects
Non-cancer: -0.35
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
~10
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
ug/L
Cancer:
Notes
Prev: Lake Champlain, NY study; Mag: 2000 Florida study
Cyanobacterial toxin
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Aniline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 49 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Aniline
2438
62533
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.007
0.007
2.5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1993
Critical Effect
Blood- effects; Spleen-effects
spleen
Blood - pigmented or nucleated red blood cells, Blood -
methemoglobinemia-carboxyhemoglobin, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - other esterases
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.6
0.0057
0.0057
B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1987
spleen
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
49
6
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
98 L' L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Provisional value; 104-week chronic study in rat for aniline hydrochloride. CUT,
1982.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; CIIT.1982; Basis LOAEL 7.2 mg/kg-d; rat; UF = 1,000
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 12 week oral study in rats; GISAAA Gigiena i Sanitariya. For
English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 24(7), 44,1 959
Supplemental Data
from IRIS
Vol. 27, Suppl. 7; 1987
EPA, CACART, OEHHA, RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Aniline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 50 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
1,903
937,263
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
7
20
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
ndustrial chemica ; as solvent; synthesis of explosives, rubber accelerators, isocyanates (HSDB)
Value
44.78
0.9
2.02E-06
36000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades Fast
-------
Bensulide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 51 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Bensulide
9553
741582
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.005
271
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Plasma & brain ChE inhibition, decreased body weight
gain
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
35
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
10 6 Li
HRL Ratio(s)
NC HRL/SWC EEC: 0.224
Notes
Reference Dose; Basis = NOAEL 0.5 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
Volume(issue)/page/year-,C42,1991
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Bensulide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 52 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
545,406
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
34
Units
States
States
States
Year
1997
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 158 ug/L
Ground water chronic: 1 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.224
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
Herbicide (HSDB)
Value
9.15E-09
15
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = Biodegrades Slowly with Acclimation
-------
Benzyl chloride
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 53 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Benzyl chloride
4107
100447
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
26.6
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cardiac - other changes, Gastrointestinal - necrotic
changes, Related to Chronic Data - death
Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.02
0.17
0.17
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1989
Thyroid
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
62
0.2
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude , „ ,
75 L' L
HRL Ratio(s)
No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JJIND8 JNCI, Journal of the National Cancer Institute.
(Washington, DC) V. 61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year
76,1231,1986; 26 week oral study in rats
Supplemental Data
2B from IARC
Lijinsky, 1986
CACART, EPA, RAIS, OEHHA, IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Benzyl chloride
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 54 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Krasner, etal., 2006
HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
259
18,750
n
PWSs/Sites/Sa
mples
12
Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0
Number of
States
3
10
%
PWSs/Sites/Sam
pies with
detects
0
Units
States
States
States
Minimum value of
Detects
Not Detected
Non-cancer:
Amount Range
>50M-100M
>50M-100M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Not Detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not Detected
90% of
Detects
Not Detected
Units for Mag
data
Notes
Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185.
Cancer:
Chemical intermed ate (NTP)
Value
517.8
2.3
4.11E-04
20
27
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
-------
Butylated hydroxyanisole
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 55 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Butylated hydroxyanisole
28160
25013165
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.249
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1959
Critical Effect
Liver - changes in liver weight
Prevalence Magnitude
8 4 NLi
HRL Ratio(s)
NC HRL/NREC NA GW MED: 0.484
CAR HRL/NREC NA GW MED: 146
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; AJEBAK Australian Journal of Experimental Biology and
Medical Science. (Adelaide, S.A., Australia) V.1 -64, 1 924-86. Volume(issue);page/year 37,533,1 959
Supplemental Data
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification
0.0002
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
Vol. 40, Suppl. 7, 1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.581
175
Y/N
Y/N
ug/L
ug/L
CACART; OEHHA; IARC
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Butylated hydroxyanisole
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 56 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal.,2002
Focazio, etal., 2008
HRL Ratios (HRL/NREC NA GW MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
85
# Sam pies
Amount
Released
n
PWSs/Sites/Sa
mples
2
#with Detects
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
2.4
% Samples with
detects
3
0.61
Number of
States
%
PWSs/Sites/Sam
pies with
detects
Minimum value of
Detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.484
Amount Range
>500K-1M
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Maximum
value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
0.2
Not detected
0.1
Median value of
Detects
0.2
1.2
90% of
Detects
99% of Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
ug/L
ug/L
Cancer: 146
Notes
National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci.
&Technol.,36(6), pp. 1202-1211.
A national reconnaissance for Pharmaceuticals and other organic
wastewater contaminants in the United States ~ II. Untreated drinking
water sources. Focazio, etal., 2008. Sci. Tot. Env., 402(2-3), pp. 201-
216.
Food additive (antoxidant) (HSDB)
Value
38 days
1,390
3.5
1.17E-06
15
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slow with acclimation (PBT)
-------
Captan
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 57 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Captan
5825
133062
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.13
0.13
0.1
19.9
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
1995
Critical Effect
Decreased pup body weight
Kidney, Ureter, Bladder - other changes in urine
composition, Blood - pigmented or nuceated red blood
cells, Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - transaminases
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0024
0.0035
0.0023
3
mg/L
(mgftg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
910
14.6
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/SWC EEC: 84.3
CAR HRL/SWC EEC: 1.35
Notes
Reference Dose; Basis = NOEL 12.5 mg/kg-d; UF = 100
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see
HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 38(9), 24,1 973
Supplemental Data
CACART; EPA; OEHHA; RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Captan
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 58 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
3,992,782
15
2,938
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
39
3
6
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 10.8 ug/L
Ground water chronic: 0 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 84.3
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 1.35
Fungicide (NTP)
Value
862.2
2.8
7.01 E-09
5.1
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = Biodegrades Sometimes/Reca citrant. However, hydrolysis half-life s 4.9 hrs - 1 8.8 hrs @ pH 7 and 5, respectively.
-------
Chlorate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 59 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Chlorate
24376
14866683
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.03
5
1.4
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2005
Critical Effect
Thyroid hypertrophy and mineralization
Bone marrow hyperplasia; thyroid folicular hypertrophy
and mineralization
Blood - pigmented or nucleated red blood cells, Blood -
changes in erythrocyte (RBC) count, Nutritional and Gross
Metabolic - weight loss or decreased weight gain
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Not likely to be carcinogenic at
doses that do not alter thyroid
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
210
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
10 10
HRL Ratio(s)
NC HRL/DBP ICR 90% : 0.656
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data - NTP Abstract for TR-51 7; 2-year rat study for sodium chlorate
Lowest Observed Adverse Effect Level; 1-year oral rat study fopr sodium chlorate; Journal of
Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466)
V.5(4)- 1984- Volume(issue)/page/year
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Chlorate
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 60 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
DBP ICR finished water
# PWSs/Sites
sampled
1,713
#with Detects
1,490
% PWSs/Sites
with detects
86.7
Mean value of
Detects
172
Maximum
value of
Detects
2,234
Median value of
Detects
120
90% of
Detects
320
99% of Detects
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
HRL Ratios (HRL/DBP ICR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
7,261,557
n
PWSs/Sites/Sa
mples
116
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
66
Number of
States
16
%
PWSs/Sites/Sam
pies with
detects
56.9
Units
States
States
States
Median of Detects
110
Non-cancer: 0.656
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
1997
2004
2004
Maximum of
Detects
747
Units for Mag
data
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
For sodium chlorate
Units for Mag data
ug/L
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.aspx
Cancer:
Agricultural defol ant or desiccant and in the production of CIO 2 (HSDB).
Value
1,000,000
Units
days
L/kg
unitless
cm3/g
atm-m3/mol
mg/L
Degradation
Code
Notes
For sodium chlorate
-------
Chloromethane (Methyl chloride)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 61 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Chloromethane (Methyl chloride
2605
74873
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.004
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Mild neurological effects in humans occupationally
exposed to Chloromethane
Cancer Data
EPA Lifetime Cancer Risk, ICT*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.013
D
3
mg/L
(mg/kg-d)-'
(mg/kg-d)"1
1981
2001
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
28
2.69
Y/N
Y/N
mg/L
ug/L
ug/L
2006
developmental
Teratogen
Prevalence Magnitude , „ ,
87 L' L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 2.15
CAR HRL/NCOD R1 90%: 0.207
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CUT, 1981
Vol. 41,Suppl. 7, Vol. 71; 1999
CACART, RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Chloromethane (Methyl chloride)
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 62 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NGOD Round 2 finished water
NIRS finished water
20,246
23,478
248
528
1.22
2.25
0.01
0.00073
550
312
1.9
1.4
13
5
120
29
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
Krasneretal., 2006
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
3,959
Amount
Released
1,539
1,733,197
n
PWSs/Sites/Sa
mples
11,984
12
356
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
247
1
8.99
Number of
States
10
26
%
PWSs/Sites/Sam
pies with
detects
2.1
8
0.007
Units
States
States
States
Minimum value of
Detects
0.25
Non-cancer: 2.15
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
21
Year
2004
2004
Maximum
value of
Detects
46
0.04
0.1
0.58
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.7
ND
90% of
Detects
2
Units for Mag
data
ug/L
ug/L
Cancer: 0.207
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185.
Foaming agent; in organic synthes s (HSDB); naturally-occurring gas
Value
15
14
0.91
8.82E-03
5320
43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = Biodegrades Slowly
-------
Clethodim
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 63 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Clethodim
76719
110429624
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.01
0.01
1,360
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Increased liver weights increased liver enzymes and
iver histopathology
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
70
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
10 6 Li
HRL Ratio(s)
NC HRL/SWC EEC: 9.21
Notes
Reference Dose; Basis = NOEL 1 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Oral study in rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH
44094) Volume(issue)/page/year -,C272,1991
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Clethodim
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 64 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
670,721
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
39
Units
States
States
States
Year
1997
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data:
OPP Estimated Environmental Concentration
Surface water chronic: 7.6 ug/L
Ground water chronic: 0.49 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 9.21
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
Herbicide; pesticide degradate
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Cobalt
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 65 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Cobalt
18870
7440484
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.02
0.01
0.0014
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2004
2000
Critical Effect
Blood-increased hemoglobin, polycythemia;
respiratory-effects on lung function
Heart
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1991
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
70
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,,, _
4 8 NL'
HRL Ratio(s)
NCHRL/NIRS90%:6.67
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; 'multiple studies as cited in ATSDR, 1992; UF = 30; human study; RIVM; Basis
LOAEL = 0.04 mg/kg-d
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Vol. 52; 1991; NB: Evaluated as a group; Cancer classifications were used for screening, but no related
quantitative cancer risk data were identified for potency scoring.
IARC, CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Cobalt
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 66 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
3
0.303
6.4
10.6
9.7
10.5
10.6
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
3,297
Amount
Released
1,272
786,491
# PWSs/Sites
sampled
782
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
23.7
Number of
States
17
38
% PWSs/Sites
with detects
0.007
Units
States
States
States
Minimum value of
Detects
Non-cancer: 6.67
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
684
Year
2004
2004
Maximum
value of
Detects
0.22
3.91
53.2
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data are for cobaltous chloride: Formerly in medicines; as germicide (HSDB); naturally-occurring
Value
534,200
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BST
Notes
assumed persistent; All use and env. fate data are for cobaltous chloride; BST = biodegrades sometimes/reca citrant
-------
Cumene hydroperoxide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 67 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Cumene hydroperoxide
2927
80159
Attribute Scores
Potency Severity
4 9
Prevalence Magnitude
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
32.7
382
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Mortality
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
76.4
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; AIHAAP American Industrial Hygiene Association Journal.
(AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issueXpage/year
19,205,1958; 7 week oral study in rats
Supplemental Data
Oral study in rats
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Cumene hydroperoxide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 68 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
96
443,772
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
15
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
ndustrial chemical (HSDB)
Value
2.16
4.71 E-08
13,900
25
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades Slowly with Acclimation; PBT
-------
Cylindrospermopsin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 69 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Cylindrospermopsin
81115
143545908
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00003
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg*g-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Increased kidney weight
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.21
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „
5 10 L'
Scores based on supplemental data HRL Ratio(s)
c^notoxTsuryr00" *"** °" ""** NC HRL/CyanoHABs MAX: -0.0021
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis LOAEL 60 ug/kg-d; NOAEL 3 ug/kg-d. Humpage, A.R. and I.R.
Falconer. 2003. Oral toxicity of the cyanobacterial toxin Cylindrospermopsin in male Swiss albino
mice: Determination of no observed adverse effect level for deriving a drinking water guideline
value. Environ. Toxicol. 18(2):94-103.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Cylindrospermopsin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 70 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CyanoHABs - The Florida Experience
UCMR 1 Meeting summary
HRL Ratios (HRL/CyanoHABs MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
Not Available
Not Available
Units
States
States
States
Minimum value of
Detects
Non-cancer: -0.0021
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
-100
90
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
2000 Florida study
Florida survey
Cyanobacterial toxin
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Dicrotophos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 71 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dicrotophos
6098
141662
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00007
0.0001
0.0001
11
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
Critical Effect
Decreased plasma, RBC & brain ChE activity
Decreased body weight
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
Suggestive
evidence
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.49
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 2.45
Notes
Reference Dose; Basis = LOAEL 0.02 mg/kg-d; UF = 300.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa,
Ont, Canada) Volume(issue)/page/year 6,196,1973
OPP; no quantif cation
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Dicrotophos
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 72 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
359,726
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
13
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
Maximum
value of
Detects
0
0
Surface water chronic: 0.2 ug/L
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
0
0
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA); 2002
2002
Ground water chronic: 0.005 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 2.45
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
nsecticide (HSDB)
Value
366.2
-0.49
5.05E-11
1,000,000
39
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = Biodegrades Slowly
-------
Dimethipin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 73 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dimethipin
36818
55290647
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0218
0.02
0.02
0.02
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
1999
Critical Effect
Kidney, lungs, duodenum, liver, glandular stomach,
heart, aortic artery & testes toxicity. Decreased body
weight gain.
ncreased absolute and relative liver weight
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
C
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
153
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
8 5 Li
HRL Ratio(s)
NC HRL/GWC EEC: 1.55
Notes
Reference Dose; Basis = NOEL 2.1 8 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Dimethipin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 74 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
282,458
0
250
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
14
0
1
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 7.3 ug/L
Ground water chronic: 99 ug/L
HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.55
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
Herbicide; plant growth regulator (HSDB)
Value
27.41
-0.17
2.30E-11
4,600
46
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = biodegrades slowly with acclimation; PBT
-------
Dimethoate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 75 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dimethoate
2413
60515
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0022
0.0002
0.0002
0.002
3
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2007
1988
1996
Critical Effect
Brain cholinesterase inhibition
Brain cholinesterase nhibition
Blood - other changes, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - true
cholinesterase
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
C
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
2006
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
15.4
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude , „ ,
10 7 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 0.655
Notes
Reference Dose; OPP RED
Reference Dose; Basis NOEL 0.05 mg/kg-d; UF = 100. American Cyanamid Co., 1986a
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level - 52-week study in rat; BJIMAG British Journal of Industrial
Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
Volume(issue)/page/year21,52,1964
Supplemental Data
OPP
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Dimethoate
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 76 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
CAL DHS
STORE!
Amount
Released
1,896,947
2,615
31,480
n
PWSs/Sites/Sa
mples
n
PWSs/Sites/Sa
mples
7,238
890
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
4
#with Detects
0
14
Number of
States
44
2
4
%
PWSs/Sites/Sam
pies with
detects
1.3
%
PWSs/Sites/Sam
pies with
detects
0
1.57
Units
States
States
States
Minimum value of
Detects
Minimum value of
Detects
0.055
Year
1997
2004
2004
Maximum
value of
Detects
0.022
Maximum
value of
Detects
0.21
Surface water chronic: 23.5 ug/L
Non-cancer: 0.655
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.148
95% of
Detects
90% of
Detects
0.198
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Ground water chronic: 0.044 ug/L
Cancer:
Pesticide (NTP)
Value
8
5.2-36
0.78
2.43E-10
23,800
36
Units
weeks
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = biodegrades slowly with acclimation
-------
Disulfoton
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 77 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Disulfoton
6423
298044
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00013
0.00004
0.0001
0.00004
0.00006
0.0003
0.06
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2002
1986
2006
08/1995
1991
Critical Effect
Plasma, RBC, brain & corneal ChE inhibition
Brain and Coverings - other degenerative changes, Blood -
other changes, Biochemical - Enzyme inhibition, induction,
or change in blood or tissue levels - true cholinesterase
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
E
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.0035
0.91
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NCHRL/NAWQA90%: 1.1
Notes
Reference Dose; Basis = NOAEL 0.013 mgrtsg-d; UF = 100.
Reference Dose; Basis = LOAEL 0.04 mg/kg-d; UF = 1 ,000.
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press,
Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
Volume(issue)/page/year35,101,1997
Supplemental Data, ITER
Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for
potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.
-------
Disulfoton
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 78 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300
0
0
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118
Amount
Released
1,196,066
n
PWSs/Sites/Sa
mples
17
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
0.24
Number of
States
33
%
PWSs/Sites/Sam
pies with
detects
0
0
0.002
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.1
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
3.81
Year
1997
Maximum value
of Detects
Not Detected
Not Detected
0.02
0.826
3.81
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of Detects
Not Detected
Not Detected
Units for Mag
data
Cancer:
Notes
Pesticide Pilot Mentoring Program (USGS/EPA); 2002
2002
nsecticide (HSDB)
Value
7-41
684-14,013
4.02
2.20E-06
16.3
17
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
BS = Biodegrades Slowly
-------
Diuron
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 79 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Diuron
6583
330541
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.003
0.002
0.003
0.002
1.75
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
2006
Critical Effect
Hemolytic anemia & compensatory hematopotesis
(decreased erythrocyte count, hemoglobin level, etc).
Blood - changes in serum composition (e.g. TP, bilirubin,
cholesterol), Liver - changes in liver weight, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - transaminases
Cancer Data
EPA Lifetime Cancer Risk, 104
EPA OPP Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0191
Known/Likely
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
2003
2003
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
21
1.83
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Teratogen
Prevalence Magnitude
4 7 NL!
HRL Ratio(s)
NCHRL/UCMR90%: 10
CAR HRL/UCMR 90%: 0.871
Notes
Reference Dose; du Pont, 1364a; Basis = LOAEL 1 .0 mg/kg-d; UF = 300.
Reference Dose; Basis NOEL 0.625 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-day study in rat; TXAPA9 Toxicology and Applied
Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year36,76,1990
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
EPA, CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Diuron
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 80 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
298
1
0.34
2.1
2.1
2.1
2.1
2.1
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,552
Amount
Released
4,370,448
10
798
n
PWSs/Sites/Sa
mples
270
319
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
117
13
7.00
Number of
States
39
2
5
%
PWSs/Sites/Sam
pies with
detects
0.4
37.5
5.8
0.0004
Units
States
States
States
Minimum value of
Detects
0.058
Non-cancer: 10
Amount Range
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
23.3
Year
1997
2004
2004
Maximum
value of
Detects
0.058
0.54
0.079
0.09
0.915
8.4
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
0.319
0.079
Units
ug/L
ug/L
ug/L
Cancer: 0.871
Notes
Pesticide Data Program (USDA); 2002
Herbicide (HSDB
Value
224-879
2.68
5.8E-10
36.4
15
Units
months
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BST
Notes
BST = biodegrades sometimes/recalcitrant
-------
Equilenin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 81 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Equilenin
81750
517099
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
9 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormonal response in post-menopausal
women
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
3-model Categorical Prediction
L?-L
HRL Ratio(s)
NC HRL/Kolpin MAX: 1.26
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Equilenin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 82 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
2.8
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.26
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.278
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.14
90% of
Detects
Units for Mag
data
ug/L
Notes
National Surfac
Sci.&Technol
e Water Reconnaissance; Kolpin, etal., 2002. Env.
36(6), pp. 1202-1211.
Cancer:
Pharmaceutical, hormone
Value
3.93
1.52
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Equilin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 83 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Equilin
81748
474862
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
8 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormonal response in post-menopausal
women
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
3-model Categorical Prediction
L?-L
HRL Ratio(s)
NC HRL/Kolpin MAX: 2.38
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Equilin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 84 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
ro
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
1.4
Units
States
States
States
Minimum value of
Detects
Non-cancer: 2.38
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.147
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.147
90% of
Detects
Units for Mag
data
ug/L
Notes
National Surfac
Sci. & Technol
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.
Cancer:
Pharmaceutical, hormone
Value
38
3.35
1.41
13
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slowly with acclimation
-------
Erythromycin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 85 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Erythromycin
75632
114078
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0007
66.7
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Inhibition of beneficial gastrointestinal bacteria
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
4.9
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
10 4
HRL Ratio(s)
NC HRL/NREC MAX: 2.88
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Erythromycin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 86 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Focazio, etal., 2008
HRL Ratios (HRL/NREC MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
104
90
Amount
Released
n
PWSs/Sites/Sa
mples
22
0
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
21.5
0.0
Number of
States
%
PWSs/Sites/Sam
pies with
detects
Not detected
Units
States
States
States
Minimum value of
Detects
Non-cancer: 2.88
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
1.7
Not detected
Year
Maximum
value of
Detects
0.3
0.1
Not detected
Not detected
Not detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
90% of
Detects
Units for Mag
data
ug/L
Notes
Drinking water monitoring; Focazio, etal., 2008. Sci.Tot. Env. 402(2-3),
pp. 201-216.
Cancer:
Pharmaceutica , antibiotic
Value
180
3.06
5.20E-29
6
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = Biodegrades sometimes/recalcitrant
-------
Estradiol (17-beta estradiol)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 87 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estradiol (17-beta estradiol)
2130
50282
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormona response in post-menopausal women
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
39
1
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.35
0.0009
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude ,
10 5 L
HRL Ratio(s)
NC HRL/Kolpin MAX: 1.75
CAR HRL/Kolpin MAX: 0.0045
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
IARC, CACART, OEHHA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Estradiol (17-beta estradiol)
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 88 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
85
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0.0
10.6
Units
States
States
States
Minimum value of
Detects
Not detected
Non-cancer: 1.75
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Not detected
0.0064
0.2
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not detected
0.16
90% of
Detects
Not detected
Units for Mag No(es
data
ug/L
ug/L
ug/L
Cancer: 0.0045
Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
National Surface Water Reconnaissance; Kolpin, et al., 2002. Env.
Sci.&Techno ., 36(6), pp. 1202-1211.
Pharmaceutical, hormone
Value
38
4.01
6.40E-11
3.6
11
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slowly with acclimation
-------
Estriol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 89 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estriol
75525
50271
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
10 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormonal response in post-menopausal
women
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
3-model Categorical Prediction
L?
HRL Ratio(s)
NC HRL/Kolpin MAX: 6.86
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Estriol
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 90 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0.0
0.0
21.4
Units
States
States
States
Minimum value of
Detects
Not detected
Not detected
Non-cancer: 6.86
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Not detected
Not detected
0.051
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not detected
Not detected
0.019
90% of
Detects
Not detected
Not detected
Units for Mag
data
ug/L
ug/L
ug/L
Cancer:
Notes
Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
National Surfac
Sci. & Techno .
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.
Pharmaceutica , hormone
Value
38
2.45
1.33E-12
441
17
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slowly with acclimation
-------
Estrone
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 91 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estrone
2210
53167
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Estrogenic hormonal response in post-menopausal
women
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
9 3 Li
HRL Ratio(s)
NC HRL/Swartz MAX: 2.92
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Estrone
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 92 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Boyd, etal.,2003
Snyder, 2008
Kolpin.etal., 2002
Swartz, etal.,2006
HRL Ratios (HRL/Swartz MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
7.1
Units
States
States
States
Minimum value of
Detects
Not detected
Non-cancer: 2.92
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Not detected
0.002
0.112
0.12
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not detected
0.027
90% of
Detects
Not detected
Units for Mag No(es
data
Finished Drinking Water; Boyd, etal, 2003. Sci. Tot. Env. 311(1-3): pp.
135-149.
ug/L
ug/L
ug/L
Cancer:
Raw Drinking Water; Snyder, et al, 2008. Removal of Endocrine
Disrupters and Pharmaceuticals during Water Treatment. In: Fate of
Pharmaceuticals in the Environmental and in Water Treatment Systems.
National Surfac
Sci. & Technol
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.
Ambient Water (SW/GW); Swartz, et al., 2006. Env. Sci. & Technol.
40(16): pp. 4894-4902.
Pharmaceutical, hormone
Value
38
3.13
3.80E-10
30
13
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades slowly with acclimation
-------
Ethinyl Estradiol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 93 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethinyl Estradiol (17-alpha ethynyl estradiol)
2327
57636
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.04
0.015
0.0005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
1981
Critical Effect
Hematalogical effects
Increased serum levels of alanine aminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GGT).
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.28
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
10 4 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.337
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, etal., 1981 as cited in Maier and Hermann, 2001.
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)
CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Ethinyl Estradiol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 94 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0.0
0.0
5.7
Units
States
States
States
Minimum value of
Detects (ug/L)
Not detected
Not detected
Non-cancer: 0.337
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects (ug/L)
Not detected
Not detected
0.273
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects (ug/L)
Not detected
Not detected
0.094
90% of
Detects (ug/L)
Not detected
Not detected
Units for Mag
data
ug/L
ug/L
ug/L
Cancer:
Notes
Finished Drinking Water; Snyder, et al., 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al., 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Response to Comment on National Surface Water Reconnaissance
Kolpin et al., 2002: Env. Sci. & Technol., 36(18), pp. 4007-4008.
Pharmaceutical, hormone
Value
60
3.67
7.94E-12
11.3
9
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = Biodegrades sometimes/recalcitrant
-------
Ethoprop
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 95 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethoprop
22682
13194484
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0001
0.0004
33
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
Critical Effect
Plasma ChE inhibition, Q1* 0.0281 (mg/kg-day)-1 -
Likely.
Behavioral - changes in motor activity (specific assay),
Behavioral - muscle contraction or spasticity
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.12
0.0281
Likely
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-dr1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.7
1.25
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,,, _
7 3 NL'
HRL Ratio(s)
NC HRL/NAWQA 90%: 7.29
CAR HRL/NAWQA 90%: 13
Notes
Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
Volume(issue)/page/year 1 ,693,2001
OPP RED and Ethoprop pesticide tolerances: 73 FR 53725, Spetember 17, 2008
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Ethoprop
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 96 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118
Amount
Released
1,010,807
0
77,786
n
PWSs/Sites/Sa
mples
84
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
1.18
Number of
States
28
0
4
%
PWSs/Sites/Sam
pies with
detects
0
0
0.002
Units
States
States
States
Minimum value of
Detects
Non-cancer: 7.29
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
1.95
Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
0.011
0.096
0.8
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer: 13
Notes
Pesticide Pilot Mentoring Program (USGS/EPA); 2001
2001
nsecticide (HSDB)
Value
75-133
70-120
3.59
1.70E-07
750
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
hydrolysis only: BST = biodegrades sometimes/recalcitrant
-------
Ethylene glycol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 97 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene glycol
4599
107211
Attribute Scores
Potency Severity
3 9
Prevalence Magnitude
10 10
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
2
2
2
0.8
0.05
600
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1987
2006
2007
2000
Critical Effect
Kidney toxicity. Increased mortality, neutrophil count,
kidney hemoglobin & hematocrit, chronic nephritis
ncreased total malformations and incidence of extra rib 14
in developmental study
Kidney
Behavioral - fluid intake, Kidney, Ureter, Bladder - changes
in tubules (including acute renal failure, acute tubular
necrosis), Related to Chronic Data - death
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
70
14,000
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Teratogen
3-model Categorical Prediction
L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; DePass et al., 1986a; UF = 100; Rat; Basis NOAEL = 200 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; Gaunt etal., 1974; UF = 1,000; Rat
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 2 year oral study in rate; FCTXAV Food and Cosmetics
Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year3,229,1965
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Ethylene glycol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 98 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
576,990
10,076,483
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
31
49
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Antifreeze; cancelled pesticide; synthetic chemical used in textile manufacture (NTP)
Value
1
-1.36
6.00E-08
1,000,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
Ethylene Oxide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 99 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene Oxide
2635
75218
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
1.02
0.31
1
mg/L
(mg/kg-d)-1
(mg/kg-d)-'
1994
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.113
Y/N
Y/N
ug/L
ug/L
Teratogen; Developmental
Prevalence Magnitude
10 8
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
HEAST
CACART; RAIS; OEHHA; EPA; IARC
UMD; CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Ethylene Oxide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 100 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
4,761
374,110
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
4
38
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Fumigant (NTP); gas
Value
1.435
-0.3
1.48E-04
1,000,000
43
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BS
Notes
PBT; BS = biodegrades slowly
-------
Ethylene thiourea
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 101 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene thiourea
3836
96457
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0002
0.00008
0.00008
0.00008
0.004
1.34
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1991
2006
1993
Critical Effect
Thyroid toxicity
ncreased incidence of thyroid hyperplasia
Nutritional and Gross Metabolic - weight loss or decreased
weight gain
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.006
0.06
0.045
B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1988
2001
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.003
1.4
0.06
Y/N
Y/N
mg/L
W/L
W/L
2006
Teratogen; Developmental
Prevalence Magnitude
4 1 NLi
HRL Ratio(s)
NC HRL/GWC EEC: 6.67
CAR HRL/GWC EEC: 0.286
Notes
Reference Dose
Reference Dose; Basis LOAEL 0.25 mg/kg-d. Graham etal., 1975
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 8-week study in rat; JAFCAU Journal of Agricultural and Food
Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn.,
Washington, DC 20037) V.1- 1953- Volume(issue)/page/vear 21,324,1973
Supplemental Data
OPP
OPP
EPA; RAIS; OEHHA; IARC; CACART
UMD; CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Ethylene thiourea
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 102 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
5
299
Units
Ibs/yr
Ibs/yr
Ibsfyr
Number of
States
1
4
Units
States
States
States
Year
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 0.1 ug/L
Ground water chronic: 0.21 ug/L
HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 6.67
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.286
Pesticide (NTP)
Accelerator; industrial intermediate (HSDB)
Value
15
6.5
-0.66
3.40E-07
20,000
48
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
(at 30 C)
-------
Fenamiphos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 103 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Fenamiphos
27401
22224926
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0001
0.00025
0.0001
0.00025
0.0008
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
2006
1997
Critical Effect
Plasma ChE inhibition.
Cholinesterase inhibit on
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
E
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1988
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.0035
0.7
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 0.051
Notes
Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100.
Reference Dose; Basis = NOEL 0.025 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring. OPP changed cancer classification from D to E.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Fenamiphos
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 104 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
726,675
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
14
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
1997
Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 13.7 ug/L
Non-cancer: 0.051
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Ground water chronic: 0.47 ug/L
Cancer:
nsecticide (HSDB)
Value
225.1
3.23
1.21E-09
329
12
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BSA
Notes
BSA = biodegrades slowly with acclimation; PBT
-------
Formaldehyde
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 105 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Formaldehyde
2119
50000
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.2
0.2
0.2
0.2
12.5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1990
2006
1999
Critical Effect
Reduced weight gain, histopathology in rats.
Decreased absolute heart, liver, testes & kidney
weights. Increased relative brain, testes weights.
Gastro.
Liver - other changes, Blood - changes in spleen
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
B1
2A
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1993
1995
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
7
1,400
Y/N
Y/N
ug/L
ug/L
ug/L
2006
Teratogen
Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/DBP ICR MED: 184
Notes
Reference Dose
Reference Dose; Basis = NOAEL 15 mg/kg-d; UF = 100. Til etal., 1989
Reference Dose
Reference Dose
Minimal Risk Level; Basis = NOAEL 15 mg/kg-d; ATSDR MRL-int = 0.3 mg/kg-d (Til etal., 1989).
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VCVGK Vrednie chemichescie veshestva, galogen I kislorod
sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing
substances), Bandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,339,1994
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
CACART; EPA; IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Formaldehyde
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 106 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
DBP ICR
# PWSs/Sites
sampled
227
#with Detects
126
% PWSs/Sites
with detects
55.5
Minimum value of
Detects
5
Maximum
value of
Detects
30.6
Median value of
Detects
7.6
99% of
Detects
29.7
Units for Mag
data
ug/L
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
HRL Ratios (HRL/DBP ICR MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
326,298
26,992,234
Units
Ibs/yr
Ibs/yr
Ibs/yr
Number of
States
31
46
Units
States
States
States
Non-cancer: 184
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
Notes
Notes
ug/L
ug/L
ug/L
ug/L
ug/L
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Cancer:
Naturally-occurring fungicide (NTP); Disinfection by-Product; gas
Value
1
0.35
3.38E-07
400,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = Biodegrades Fast with Acclimation
-------
Germanium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 107 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Germanium
18876
7440564
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.318
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Kidney, Ureter, Bladder - changes in tubules (including
acute renal failure, acute tubular necrosis)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.744
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
4 10 Li
HRL Ratio(s)
NC HRL/NIRS 90% : 0.003
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JJMDAT Japanese Journal of Medicine. (Nankodo Co.,
Ltd., POBS272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information,
see IEDIEP. Volume(issue)/page;year 30,67,1991. EPA believes the RTECS LOAEL may be
incorrectly cited (should be 3.18 not 0.318). Both values suggest listing germanium.
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Germanium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 108 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
4
0.40
2B
230
220
220
230
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.003
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data are for germanium diox de: Phosphors, transistors and diodes; electroplating (HSDB); naturally-occurr ng
Value
4,470
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BST
Notes
assumed persistent; All use and env. fate data are for germanium dioxide; BST = biodegrades sometimes/reca citrant
-------
Halon 1011 (bromochloromethane)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 109 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Halon 1011 (bromochloromethane)
2613
74975
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.01
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
ncreased liver-to-body weight ratio. Cloudy swelling
and vacuolization of hepatocytes.
Prevalence Magnitude
5 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 7
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.5
70
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For care nogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Halon 1011 (bromochloromethane)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 110 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NGOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
12,881
22,974
65
106
0.5
0.461
0.05
0.0023
210
33.4
1
1
10
6
210
27.9
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
Krasner, etal., 2006
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1/2, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,238
^Samples
Amount
Released
n
PWSs/Sites/Sa
mples
7
#with Detects
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.165
% Samples with
detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0.1
0.0
0.01
Minimum value of
Detects
Units
States
States
States
Minimum value of
Detects
Not detected
Non-cancer: 7
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.45
Maximum
value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
Not detected
0.2
Median value of
Detects
0.422
90% of
Detects
0.45
99% of Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes
Median value of
Detects
1
Not detected
99% of
Detects
Not detected
Units for Mag
data
ug/L
Cancer:
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx
Krasner, etal., 2006. Env. Sci. &Technol. 40 (23): pp. 7175-7185.
Fire extinguishing fluid; chemical intermediate (HSDB)
Value
15 days
23.7
1.41
0.00146
16,700
40
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
BS = Biodegrades slow (PBT)
-------
HCFC-22
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 111 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
HCFC-22
2654
75456
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
13.5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1983
Critical Effect
Brain and Coverings - other degenerative changes,
Blood - changes in other cell count (unspecified),
Nutritional and Gross Metabolic - weight loss or
decreased weight gain
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
31.5
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 10 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26-week study in rat; GISAAA Gigiena i Sanitariya. For
English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-
1936- Volume(issue)/page/year 48(8),69,1983
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
HCFC-22
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 112 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
2,972
7,075,769
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
35
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Refrigerant; low-temperature solvent; fluorocarbon resins, especially tetrafluoroethylene polymers (HSDB); gas
Value
15
35.04
1.08
4.07E-02
2,770
43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
-------
Hexane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 113 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Hexane
4858
110543
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.06
1,429
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1989
Critical Effect
Decreased body weight gain
Nutritional and Gross Metabolic - weight loss or decreased
weight gain
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
420
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
10 10 Li
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Basis LOAEL = 570 mg/kg-d, UF = 10,000, oral rat study. Health and
Environmental Effects Document for n-Hexane, ECAO-CIN-Q076, Environmental Criteria and
Assessment Office, Final Draft, September 1989.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; TIHEEC Toxicology and Industrial Health. (Princeton Scientific
Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year 1(3), 67,1985
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Hexane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 114 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
14,489
39,844,882
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
38
53
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>100M-500M
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Naturally-occurring; solvent (NTP)
Value
149
3.9
1.8
9.5
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = biodegrades fast with acclimation
-------
Hydrazine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 115 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Hydrazine
6460
302012
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.001
3
3
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.01
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
9 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART; EPA; IARC; OEHHA; RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Hydrazine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 116 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
5
165,485
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
16
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical intermed ate; rocket propellant; oxygen/chlorine scavenger (HSDB)
Value
14.3
-2.07
1.44E-08
1,000,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
Mestranol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 117 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Mestranol
2581
72333
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL (for ethinyl estradiol)
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.04
0.015
0.00083
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
1981
Critical Effect
Hematalogical effects
Increased serum levels of alanineaminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GOT).
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.28
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
94 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.688
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 .
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)
CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Mestranol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 118 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Mestranol
2581
72333
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL (for ethinyl estradiol)
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.04
0.015
0.00083
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
1981
Critical Effect
Hematalogical effects
Increased serum levels of alanineaminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GOT).
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.28
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
94 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.688
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 .
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)
CACART
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Mestranol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 119 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin.etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
4.3
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.688
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.407
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.017
90% of
Detects
Units for Mag
data
ug/L
Notes
Response to Comment on National Surface Water Reconnaissance
Kolpin et al., 2002: Env. Sci. & Technol, 36(18), pp. 4007-4008.
Cancer:
Metabolite of ethinyl estradiol
Value
60
4.68
Practically
insoluble
9
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = Biodegrades sometimes/recalcitrant
-------
Methamidophos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 120 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
965,584
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
39
Units
States
States
States
Year
1997
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 6.9 ug/L
Ground water chronic: 3.8 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.304
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
nsecticide (HSDB)
Value
3.848
-0.8
8.70E-10
1000000
39
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = Biodegrades Slowly
-------
Methanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 121 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Methanol
2508
67561
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.5
0.5
3.13
5,600
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1988
Critical Effect
ncreased SAP & SGPT& liver weight, decreased brain
weight
Liver - other changes
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
3,500
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude , „ ,
10 10 L' L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; U.S. EPA, 1986; Basis = NOEL 500 mg(kg-d; UF = 1,000; Rat
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 200 day oral study in rats; VCVGK "Vrednie chemichescie
veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen
and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year -
,89,1994
Supplemental Data
Rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie
soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al.,
Chimia, 1994. Volume(issue)/page/year -,87,1984
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Methanol
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 122 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
10,966,234
201,697,278
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
41
52
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
ndustrial solvent; gasoline additive (HSDB); anti-freeze
Value
1
-0.77
4.56E-06
1000000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades Fast
-------
Methyl bromide (Bromomethane)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 123 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Methyl bromide (Bromomethane
2601
74839
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0014
0.001
0.0014
0.003
1
29.9
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1988
2006
9/1992
1966
Critical Effect
Epithelial hyperplasia in theforestomach
Gastro
Kidney, Ureter, Bladder - other changes in urine
composition, Skin and Appendages - hair, Nutritional and
Gross Metabolic - we ght loss or decreased weight gain
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1989
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.05
9.8
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Developmental
Prevalence Magnitude , „
67 L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 0.891
Notes
Reference Dose
Reference Dose; Basis = NOAEL 1 .4 mg/kg-day; UF = 1 ,000; Rat. Danse et al.r 1984
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 2-year oral study in rat; FCTOD7 Food and Chemical Toxicology.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
Volume(issue)/page/year28,109,1990
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Methyl bromide (Bromomethane)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 124 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
20,198
23,328
155
175
0.77
0.75
0.07
0.09
43
38.1
1
1.6
11
8.1
34
27.2
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,317
Amount
Released
32,803,943
200
533,748
# PWSs/Sites
sampled
3
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.069
Number of
States
29
3
17
% PWSs/Sites
with detects
0.04
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.891
Amount Range
>10M-50M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.5
Year
1997
2004
2004
Maximum
value of
Detects
0.1
0.5
0.5
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Cancelled fumigant (NTP); gas
Value
20-26.7
9-22
1.19
7.34E-03
13,400
42
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BS
Notes
hydrolysis only; BS = biodegrades slowly
-------
Methyl tert-butyl ether
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 125 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Methyl tert-butyl ether
11918
1634044
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.3
0.01
300
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
8/1996
1991
Critical Effect
Hepatic: Decreased blood urea nitrogen levels.
Kidney, Ureter, Bladder - changes in bladder weight, Blood
- changes in serum composition (e.g. TP, bilirubin,
cholesterol), Nutritional and Gross Metabolic - changes in
calcium
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0018
3
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
2,100
19.4
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „
58 L'
HRL Ratio(s)
NC HRL/UCMR 90%: 58.3
CAR HRL/UCMR 90%: 0.539
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; Basis NOAEL 100 mg/kg-d
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in rat; JACTDZ Journal of the American College of
Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued. Volume(issue)/page/year 9(5), 525, 1990
Supplemental Data
OEHHA
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Methyl tert-butyl ether
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 126 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,617
17
0.47
5
49
9.2
36
49
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,328
Amount
Released
40,177
2,040,906
# PWSs/Sites
sampled
424
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
9.8
Number of
States
17
42
% PWSs/Sites
with detects
0.01
Units
States
States
States
Minimum value of
Detects
Non-cancer: 58.3
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
2,300
Year
2004
2004
Maximum
value of
Detects
0.3
7.85
1,800
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer: 0.539
Notes
Octane booster in gasoline; manufacture of isobutene; extraction solvent (HSDB)
Value
15
6
0.94
5.87E-04
51,000
46
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
-------
Metolachlor
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 127 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor
35270
51218452
Attribute Scores
Potency Severity
4 3
Prevalence Magnitude
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.1
0.15
0.1
0.15
25
1,150
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1995
1988
2006
Critical Effect
Decreased body weight gain
Decreased body weight gain
Behavioral - food intake (animal), Nutrtional and Gross
Metabolic - weight loss or decreased weight gain,
Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - phosphatases
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
C
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
1988
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
3.5
700
Y/N
Y/N
mg/L
ug/L
ug/L
2006
3-model Categorical Prediction
NL?
HRL Ratio(s)
NC HRL/NCOD R2 90%: 321
Notes
Reference Dose; Basis NOAEL = 9.7 mg/kg-d; UF = 100. OPP RED.
Reference Dose; Basis = NOEL 15 mg/kg-d; UF = 100. Ciba-Geigy, 1983
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989
Supplemental Data
NNGADV Nippon Noyaku Gakka shi. Journal of the Pesticide Science Society of Japan. (Nippon
Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
Volume(issue)/page/year 14,103,1989
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 ~6 cancer risk was used.
-------
Metolachlor
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 128 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
13,007
116
0.89
0.01
13.8
0.57
2.18
7.1
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
PPMP ambient water
PPMP finished water
CAL DHS
STORE!
HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,165
Amount
Released
67,336,211
n
PWSs/Sites/Sa
mples
203
582
n
PWSs/Sites/Sa
mples
7,345
2,082
1,817
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
102
233
288
198
#with Detects
15
676
25.4
8.76
1.23
Number of
States
48
%
PWSs/Sites/Sam
pies with
detects
50.2
40
89.2
86.8
%
PWSs/Sites/Sam
pies with
detects
0.2
32.5
0.0002
Units
States
States
States
Minimum value of
Detects
0.01
0.005
Minimum value of
Detects
0.05
0.00867
Non-cancer: 321
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
77.6
Year
1997
Maximum
value of
Detects
0.079
0.226
3.32
0.661
Maximum
value of
Detects
0.7
86
0.025
0.12
0.125
0.58
6.71
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.06
0.19
95% of
Detects
0.033
0.336
90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Pesticide Data Program (USDA); 2001
2002
Pesticide Pilot Mentoring Program (USGS/EPA)
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Herbicide (HSDB)
Value
47;78
22-310
3.13
9.00E-09
530
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
aerobic;anaerobic; BSA = biodegrades slow with acclimaton
-------
Metolachlor ESA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 129 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor ethanesulfonic acid (ESA)
79218
171118095
Attribute Scores
Potency Severity
2 1
Prevalence Magnitude
6 6
Scores based on parent
HEALTH EFFECTS DATA1 - See Metolachlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
21000
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
No biologically significant effects
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
>7,000
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : >3,210 (NAWQA data for metolachlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.
-------
Metolachlor ESA
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 130 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value
of Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag No(es
data
Finished Water Occurrence Data - FOR METOLACHLOR PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
13,007
116
0.89
0.01
13.8
0.57
2.18
7.1
Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
FOR METOLACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NCOD R290%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
83
318
n
PWSs/Sites/Sa
mples
7,345
2,082
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
19
198
#with Detects
15
676
Number of States
%
PWSs/Sites/Samp
les with detects
22.9
51.9
%
PWSs/Sites/Samp
les with detects
0.2
32.5
Units
States
States
States
Minimum value
of Detects
0.50
0.02
Minimum value
of Detects
0.05
0.00867
Non-cancer: >3,210
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
2.21
2.24
Maximum
value of
Detects
0.7
86
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.06
0.19
95% of
Detects
90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR ESA
2002 - FOR METOLACHLOR ESA
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.as
px
NCOD data for metolachlor - parent
Pesticide degradate
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation Code
Notes
-------
Metolachlor OA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 131 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor oxani ic acid (OA)
79220
152019733
Attribute Scores
Potency Severity
2 1
Prevalence Magnitude
6 6
Scores based on parent
HEALTH EFFECTS DATA1 - See Metolachlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
1,000
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
No biologically significant effects
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
7,000
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 3,210 (NAWQA data for metolachlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR OA
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.
-------
Metolachlor OA
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 132 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag No(es
data
Finished Water Occurrence Data - FOR METOLACHLOR PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
13,007
116
0.89
0.01
13.8
0.57
2.18
7.1
Ambient Water Occurrence Data
N AWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
FRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
FOR METOLACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NCOD R290%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KQC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
138
404
n
PWSs/Sites/Sa
mples
7,345
2,082
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
14
152
#with Detects
15
676
Number of
States
%
PWSs/Sites/Sam
pies with
detects
10.1
37.6
%
PWSs/Sites/Sam
pies with
detects
0.2
32.47
Units
States
States
States
Minimum value of
Detects
0.50
0.02
Minimum value of
Detects
0.05
0.00867
Non-cancer: 3,210
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
4.42
1.41
Maximum
value of
Detects
0.7
86
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.06
0.19
95% of
Detects
90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR OA
2002 - FOR METOLACHLOR OA
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.
aspx
NCOD data for metolachlor - parent
Pesticide degradate
Value
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Microcystin-LR
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 133 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Microcystin-LR
76859
101043372
Attribute Scores 3-model Categorical Prediction
Potency Severity
9 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.000003
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Liver effects
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.021
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
10 4
Scores based on supplemental data HRL Ratio(s)
NC HRL/AWWARF Typical Range MAX: 0.21
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y., Y. Makita, S. Nagata et al. 1 999.
No chronic oral toxicity of a low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female
Balb/C mice. Environ. Toxicol. 14(1):45-55.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Microcystin-LR
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 134 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
US and Canadian drinking water (bloom
area, source, finished water)
US and Canadian drinking water (bloom
area, source, finished water)
HRL Ratios (HRL/AWWARF Typical Range
MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
677
677
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
542
542
Number of
States
%
PWSs/Sites/Sam
pies with
detects
80
80
Units
States
States
States
Minimum value of
Detects
0.002
Non-cancer: 0.21
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.1
1,200
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Maximum of typical range of detects (AWWARF, Carmichael)
Maximum and m numum of detects (AWWARF, Carmichael)
Cyanobacterial toxin
Value
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Molinate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 135 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Molinate
12912
2212671
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001
0.002
0.002
13.1
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
1988
Critical Effect
Degeneration/demyelination in sciatic nerve and
atrophy/reserve cell hyperplasia of muscle
Reproductive toxicity. Alteration in sperm morphology,
reduced number of viable fetuses/litter, increased
number of resorptions/litter
Endocrine - other changes, Blood - normocytic anemia,
Nutritional and Gross Metabolic - body temperature
decrease
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
14
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „
1 8 L'
HRL Ratio(s)
NCHRL/UCMR90%: 2.46
Notes
Reference Dose; Basis LOAEL = 0.3 mg/kg-d, UF = 300, 2-year rat study. A Determination of the
Existence of a Common Mechanism of Toxicity and a Screening Level Cumulative Food Risk
Assessment, December 2001. OPP issued RfD as part of health assessment not the RED;
http://epa.gov/oppsrrd1/cumulative/thiocarb.pdf
Reference Dose; Basis NOEL 0.2 mg/kg-d; UF = 100. Stauffer Chemical Co., 1981
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 43 week study in rat; GISAAA Gigiena i Sanitariya. For English
translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 40(1 0) , 1 04, 1 975
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Molinate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 136 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,621
1
0.03
5.7
5.7
5.7
5.7
5.7
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118
Amount
Released
3,669,398
115
2,089
n
PWSs/Sites/Sa
mples
120
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
1.68
Number of
States
6
1
2
%
PWSs/Sites/Sam
pies with
detects
0.3
0.001
Units
States
States
States
Minimum value of
Detects
Non-cancer: 2.46
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
200
Year
1997
2004
2004
Maximum
value of
Detects
0.004
0.0372
3.41
47.9
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Units
ug/L
Cancer:
Notes
Pesticide Pilot Mentoring Program (USGS/EPA)
Herbicide (HSDB)
Value
40-160
80-120
3.21
4.10E-06
970
19
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BST
Notes
BST = biodegrades sometimes/recalcitrant
-------
Molybdenum
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 137 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Molybdenum
18825
7439987
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.005
0.005
0.005
0.03
0.5
Units
mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1992
2006
Critical Effect
increased uric acid levels
Effects on repro & fetal development (decreased
gestational weight ga n, prolonged estrus cycle, failure to
breed). Renal failure, diuresis, proteinuria
Liver - other changes, Kidney, Ureter, Bladder - other
changes, Nutritional and Gross Metabolic - weight loss or
decreased weight ga n
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1993
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.2
35
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Teratogen List
Prevalence Magnitude
98 Li
HRL Ratio(s)
NCHRL/NIRS90%: 1.17
Notes
Reference Dose
Reference Dose; Koval'skiy et al.( 1961; oral study in humans; UF = 30; Basis LOAEL = 0.14 mg/kd-
d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; UL; IOM
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1 9 week oral study in rabbits; VCVN5 "Vrednie chemichescie
veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic
substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
Volume(issue)/page/year -, 317, 1989
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Molybdenum
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 138 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
77
7.79
6.1
180
10
30
110
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.17
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data for molybdenum trioxide: As steel alloy; chemical reagent (HSDB); naturally-occurring
Value
1,066
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BST
Notes
assumed persistent; All use and env. fate data for molybdenum trioxide; BST = biodegrades sometimes/reca citrant
All use and env. fate data for molybdenum trioxide
-------
Nitrobenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 139 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Nitrobenzene
3998
98953
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.002
0.0005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2009
Critical Effect
Increased reticulocytesand methemaglobinemia
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1990
1996
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
14
Y/N
Y/N
ug/L
ug/L
Teratogen List
Prevalence Magnitude
1 10 NLi
HRL Ratio(s)
NCHRL/UCMRAM90%: 0.14
Notes
Reference Dose
Reference Dose; NTP, 1983; subchronic rat study; UF = 1,000; Basis BMDL = 1.8 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
CACART, IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Nitrobenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 140 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,064
2
0.065
21. 6
100
60.8
100
100
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
UCMR finished water
HRL Ratios (HRL/UCMR AM 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
60
350,301
# PWSs/Sites
sampled
338
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
Number of
States
1
14
% PWSs/Sites
with detects
0
Units
States
States
States
Minimum value of
Detects
Not Detected
Non-cancer: 0.14
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Not Detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
Analyzed under UCMR 1 , List 1 , Assessment
Monitoring with detection limit of 10 ug/L.
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not Detected
99% of
Detects
Not Detected
Units for Mag
data
Not Detected
Cancer:
Notes
Analyzed under UCMR 1, List 2, Screening Survey with detection limit of
0.5 ug/L.
Solvent (NTP)
Value
15
30.6-370
1.85
2.40E-05
1,800
31
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
BS = biodegrades slowly
-------
Nitroglycerin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 141 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Nitroglycerin
2252
55630
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.125
0.008
105
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cardiac - cardiomyopathy including infarction, Cardiac
- EKG changes not diagnostic of specified effects,
Biochemical - Enzyme inhibition, induction, or change
in blood or tissue levels - multiple enzyme effects
Behavioral - somnolence (general depressed activity)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.2
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.292
2
Y/N
Y/N
ug/L
ug/L
Teratogen
3-model Categorical Prediction
L?-L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26 week oral study in rats; FATOAO Farmakologiya i
Toksikologiya (Moscow), For English translation, see PHTXA6 and RPTOAN. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year
48,76,1985
Supplemental Data; RTECS LOAEL, acute human study
Oral study in rats; YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan
K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year 13,3649,1985
EPA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Nitroglycerin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 142 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
0.2
55,979
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
9
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Pharmaceutical/medication; production of explosives; Rocket propellants; (HSDB)
Value
1.62
9.87E-08
1,380
32
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades Fast
-------
N-Methyl-2-pyrrolidone
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 143 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Methyl-2-pyrrolidone
9980
872504
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.6
120
3,914
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
Critical Effect
Decreased weight gain, neurobehavioral effects,
sedative effects
Endocrine - changes in spleen weight
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
4,200
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
10 10 Li
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Tolerable Daily Intake; Basis NOAEL = 169 mg/kg-d, UF = 300, 90-day rat study, WHO/UNEP CICAD
TDI Study #35
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA
22161) Formerly U.S. Clearinghouse for Scientif c & Technical Information. Volume(issue)/page/year
OTS0528073
Supplemental Data
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(ssue)/page/year 26,1581,1976
UMD; CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
N-Methyl-2-pyrrolidone
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 144 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
17,972
6,311,503
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
13
42
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical industry solvent; solvent for pesticide appl cation for food packing materials (HSDB)
Value
-0.38
3.20E-09
1,000,000
42
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = Biodegrades Fast
-------
N-Nitrosodiethylamine (NDEA)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 145 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodiethylamine (NDEA)
2243
55185
Attribute Scores 3-model Categorical Prediction
Potency Severity
9 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.00002
150
36
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.0002
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
1 2 Li
HRL Ratio(s)
See also supplemental water data No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART; EPA; OEHHA; IARC; RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
N-Nitrosodiethylamine (NDEA)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 146 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
0
1,000
n
PWSs/Sites/Sa
mples
26
26
Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0
0
Number of
States
0
1
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Not Detected
Not Detected
Non-cancer:
Amount Range
Gasoline and lubr
Value
38
142.7
0.48
3.63E-06
106,000
53
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not Detected
Not Detected
90% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer:
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
cant additive; antioxidant; stabilizer n plastics (HSDB); Disinfection by-Product
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS/BSA
Notes
BS = Biodegrades Slowly; BSA = Biodegrades Slowly with Acclimation
-------
N-Nitrosodimethylamine (NDMA)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 147 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodimethylamine (NDMA)
2446
62759
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.000008
0.2
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
mmunological Includ ng Allergic - decrease in cellular
immune response, Immunological Including Allergic -
decrease in humoral mmune response, Related to Chronic
Data - death
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.00007
51
16
B2
2A
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1986
1987
Liver
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.056
0.00069
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude , „ ,
10 2 L' L
Scores based on supplemental data HRL Ratio(s)
NC HRL/CAL DHS 90%: 0.329
CAR HRL/CAL DHS 90%: 0.004
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JTEHD6 Journal of Toxicology and Environmental Health.
(Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year 37,351 ,1992
Supplemental Data
IRIS
(Vol. 17, Suppl. 7; 1987)
CACART; RAIS; EPA; OEHHA; IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
N-Nitrosodimethylamine (NDMA)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 148 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
409
585
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
87
0
Number of
States
%
PWSs/Sites/Sam
pies with
detects
21.3
0
Units
States
States
States
Minimum value of
Detects
0.001
Not Detected
Non-cancer: 0.329
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
440
Not Detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.009
Not Detected
90% of
Detects
0.17
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer: 0.004
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwaterfPages/Chemicalconta
minants.aspx
ndustrial solvent; antioxidant; formerly in the production of rocket fuel (HSDB); Disinfection by-Product
Value
38
12
-0.57
1.82E-06
Soluble
52
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = Biodegrades Slowly with Acclimation
@37°C
-------
N-Nitroso-di-n-propylamine NDPA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 149 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitroso-di-n-propylamine (NDPA)
8798
621647
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0005
7
7
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1987
1987
Liver
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.005
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude .,, „
2 2 NL.-L,
HRL Ratio(s)
See also supplemental water data CAR HRL/STORET 90% : 0.00049
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
IRIS
CACART; EPA; RAIS; OEHHA; IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
N-Nitroso-di-n-propylamine NDPA
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 150 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (HRL/STORET 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
0
506
n
PWSs/Sites/Sa
mples
127
1,309
Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0
22
Number of
States
0
2
%
PWSs/Sites/Sam
pies with
detects
0
1.68
Units
States
States
States
Minimum value of
Detects
Not Detected
0.19
Non-cancer:
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Not Detected
20
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not Detected
10
90% of
Detects
Not Detected
10.24
Units
ug/L
ug/L
Cancer: 0.00049
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Research chemical (HSDB); Disinfection by-Product?
Value
38
130
1.36
5.38E-06
10,000
44
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades Slowly with Acclimation
@37°C
-------
N-Nitrosodiphenylamine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 151 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodiphenylamine
3193
86306
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.02
20.5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1966
Critical Effect
Corneal opacities, epithelial hyperplasia of the bladder
and decreased weight gain
Nutritional and Gross Metabolic - weight loss or decreased
weight gain
Prevalence Magnitude ,,,
2 1 NL
HRL Ratio(s)
NC HRL/CAL DHS 90% : 1 .84
See also supplemental water data CAR HRL/CA|_ DH£. g()% . Q Og32
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; NC1 1979; Basis LOAEL, rat, UF=3000
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 17-week oral study in rabbit; GTPZAB Gigiena Truda i
Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya
Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/paae/vear 10(4). 60.1 966
Supplemental Data
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification
0.0049
0.009
B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
(mg/kg-d)-1
1987
IRIS
Cited by OEHHA
Vol. 27, Suppl. 7
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
140
7.1
Y/N
Y/N
ug/L
ug/L
CACART; EPA; OEHHA; RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
N-Nitrosodiphenylamine
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 152 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
# Sam pies
Amount
Released
0
14
n
PWSs/Sites/Sa
mples
133
#with Detects
Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
1
% Samples with
detects
Number of
States
0
2
%
PWSs/Sites/Sam
pies with
detects
0.75
Minimum value of
Detects
Units
States
States
States
Minimum value of
Detects
76.2
Non-cancer: 1.84
Amount Range
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Maximum
value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
76.2
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes
Median value of
Detects
76.2
90% of
Detects
76.2
Units for Mag
data
ug/L
Cancer: 0.0932
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Rubber and polymer additive; chemical reagent (HSDB); DBP
Value
6,154
3.13
1.21E-06
35
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = Biodegrades fast with acclimaton (BIODEG)
-------
N-Nitrosopyrrolidine (NPYR)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 153 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosopyrrolidine (NPYR)
10160
930552
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude
HEALTH EFFECTS DATA1 See also supplemental water data
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.002
2.1
2.1
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1986
1987
Liver
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.02
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
HRL Ratio(s)
No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
IRIS
CACART; EPA; OEHHA; RAIS; IARC
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
N-Nitrosopyrrolidine (NPYR)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 154 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
STORE!
HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
27
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0
Units
States
States
States
Minimum value of
Detects
Not Detected
Non-cancer:
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Not Detected
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
Not Detected
90% of
Detects
Not Detected
Units
ug/L
Notes
Cancer:
Research chemical (HSDB)
Value
38
19
-0.19
4.89E-08
1,000,000
48
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = Biodegrades Slowly with Acclimation
@37°C
-------
Norethindrone (19-Norethisteron
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 155 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Norethindrone (19-Norethisterone)
2525
68224
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0167
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
The norethindrone abel indicates that if the drug is
taken during the first trimester of pregnancy that the
riskfor hypospadia in male offspring doubles.
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
NTP Carcinogen Classification
Reasonably antic
carcinogenic
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Dated to be
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.04
Y/N
Y/N
mg/L
ug/L
ug/L
Prevalence Magnitude
10 4
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.0459
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data; Maximum Recommended Daily Dose (MRDD)
NTP 1 1th Report on Carcinogens; no quantificatio of dose-response
CACART
UMD, CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Norethindrone (19-Norethisteron
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 156 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, et al., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
70
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
%
PWSs/Sites/Sam
pies with
detects
12.8
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.0459
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
0.872
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.048
90% of
Detects
Units for Mag
data
ug/L
Notes
National Surface Water Reconnaissance; Kolpin, etal., 2002. Env.
Sci.&Technol., 36(6), pp. 1202-1211.
Cancer:
Value
60
2.97
5.80E-10
7.04
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = Biodegrades sometimes/recalcitrant
-------
n-Propylbenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 157 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
n-Propylbenzene
4328
103651
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
2.5
6,040
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Blood - changes in spleen
Behavioral - somnolence (general depressed activity)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
5.83
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
4 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 1.21
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VCVQH "Vrednie chemichescie veshestva,
galogenproisvodnie uglevodorodov". (Hazardous substances Qalogenated hydrocarbons)
Bandman A.L. et al., Chimia, 1990. Volume(issue)/page/year -,167,1990; 24 week oral study in rat
Supplemental Data
Rats; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher
information, see FCTOD7. Volume(issue)/page/year 2,327,1964
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
n-Propylbenzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 158 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
12,724
22,970
42
54
0.33
0.24
0.03
0.1
34
21
0.7
0.6
4.8
4
34
21
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309
Amount
Released
# PWSs/Sites
sampled
53
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1.23
Number of
States
% PWSs/Sites
with detects
0.004
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.21
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
47
Year
Maximum
value of
Detects
0.024
5
47
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Manufacture of methylstyrene; text le dyeing; printing solvent; asphalt and naphtha constituent (HSDB)
Value
15
495-955
3.69
1.05E-02
23.4
22
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
-------
o-Toluidine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 159 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
o-Toluidine
3768
95534
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
340
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Kidney, Ureter, Bladder - proteinuria, Blood - normocytic
anemia, Nutritional and Gross Metabol c - weight loss or
decreased weight ga n.
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.24
0.18
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
2000
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
793
0.194
Y/N
Y/N
ug/L
ug/L
Teratogen list
Prevalence Magnitude , „ ,
7 5 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VINIT Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii
(VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information
broker to obtain publications. Vo ume(issue)/page
Supplemental Data
HEAST
Vol. 77; 2000
IARC, RAIS, OEHHA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
o-Toluidine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 160 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
5
10,774
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
9
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>50M-100M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Intermediate in the manufacture of dyes, rubber, Pharmaceuticals and pesticides (HSDB)
Value
74.04
1.32
1.98E-06
16,600
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
Oxirane, methyl-
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 161 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxirane, methyl-
2661
75569
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001
26
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1981
Critical Effect
ncreased combined incidence of hyperkeratosis,
hyperplasia and papillomas.
Brain and Coverings - other degeneratve changes, Liver -
other changes, Blood - other changes
Cancer Data
EPA Lifetime Cancer Risk, 10"*
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.15
0.24
0.24
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
1990
1994
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
60.7
0.233
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
10 8
HRL Ratio(s)
No water data
Notes
Reference Dose; Basis = BMDL „ 1 .4 mg/kg-d; UF = 1 000.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 45-day study in rat; GISAAA Gigiena i Sanitariya. For English
translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 46(7), 76,1 981
Supplemental Data
CACART; RAIS; OEHHA; EPA; IARC
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Oxirane, methyl-
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 162 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
28,761
433,536
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
5
28
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical intermed ate (NTP)
Value
2.324
0.03
6.98E-05
590,000
44
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BS
Notes
PBT; BS = biodegrades slow
-------
Oxydemeton-methyl
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 163 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxydemeton-methyl
6458
301122
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00013
0.0025
10
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1967
Critical Effect
Decreased erythrocyte & brain ChE
Decreased body weight
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.91
Y/N
Y/N
ug/L
ug/L
male, female
Prevalence Magnitude
95 Li
HRL Ratio(s)
NC HRL/SWC EEC: 1.01
Notes
Reference Dose; Basis = NOAEL 0.013 mgfkg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
85JDAH "Organophosphorus Pesticides Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC
Press, Inc., 1974 Volume(issue)/page/year -,197,1974
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Oxydemeton-methyl
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 164 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
154,227
0
0
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
19
0
0
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
Surface water chronic: 0.9 ug/L
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Units
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Ground water chronic: 0.006 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.01
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
nsecticide (HSDB)
Value
-0.74
1.62E-13
1,000,000
39
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS =Biodegrades Slowly
-------
Oxyfluorfen
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 165 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxyfluorfen
34731
42874033
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.003
0.003
5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
Critical Effect
ncr. abs. liver weight; nonneoplastic lesions
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0732
C
mg/L
(mg/kg-d)-'
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
21
0.478
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 6 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 3.0
CAR HRL/SWC EEC: 0.067
Notes
Reference Dose
Reference Dose; Basis = NOEL 0.3 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4
7QG, UK) V.1- 1968- Volume(issue)/page/year 9,643,1991
EPA
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Oxyfluorfen
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 166 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
705,255
0
5
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
37
0
2
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 7.1 ug/L
Non-cancer: 3.0
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Ground water chronic: 0.08 ug/L
Cancer: 0.067
Pesticide; herbicide
Value
46,800
4.73
8.23E-07
0.116
5
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = biodegrades sometimes/recalcitrant; PBT
-------
Perchlorate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 167 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perchlorate
24310
14797730
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 1
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0007
6
Units
mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
ug/L
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2005
2000
Critical Effect
Radioactive iodide uptake inhibition (RAIU) in the
thyroid
Decreased newborn TSH
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
See notes
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-lnterimHA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
15
4.9
Y/N
Y/N
ug/L
ug/L
ug/L
Teratogen
Prevalence Magnitude .,, „
9 8 NL!'L!
HRL Ratio(s)
NCHRL/UCMR90%: 0.35
Notes
Reference Dose
Reference Dose; Basis NOEL 0.007mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; Brechner et al. 2000
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter
thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and
species differences in thyroid function (IRIS).
UMD
Interim Health Advisory; EPA is revisiting the intermin hHealth Advisory for perchlorate.
The HRL for the CCL differs from the Interim HA based on the RSC used in the health advisory (0.62)
and the default RSC (0.2) used for the CCL process.
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Perchlorate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 168 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,554
147
4.14
4
420
6.5
14
59
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.35
Amount Range
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Smokeless rocket and jet propellant; explosives; analytical chemistry, etch ng and engraving agent (HSDB)
Value
200,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
All use and env. fate data are for ammonium perchlorate.
-------
Perfluorooctane sulfonic acid
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 169 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perfluorooctane sulfonic acid (PFOS)
12176
1763231
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
EPA/FR NOAEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.1
0.03
251
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Reduced F2 Body Weight
Decreased body weights, increased liver weights,
lowered serum total cholesterol, lowered
triiodothyronine (T3) concentration, and lowered
estradiol levels
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-Provisional HA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.2
0.2
Y/N
Y/N
ug/L
ug/L
ug/L
January 2008
Prevalence Magnitude , „ ,
10 7 L' L
HRL Ratio(s)
NC HRL/MN MW MAX: 0.143
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
No Observed Adverse Effect Level in 2 generation reproductive study in rats. Supplemental Data - FR
October 18, 2000 (Volume 65, Number 202)] Perfluorooctyl Sulfonates; Proposed Significant New Use
Rule [Page 6231 9-62333]
Supplemental Data - Seacat et al., 2002, Toxicol. Sci. 68, 249-264. EPA Provisional HA:
http://www.epa.gOV/waterscience/criteria/d rinkinglpha-PFOA_PFOS.pdf
Lowest Observed Adverse Effect Level
Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf
Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). The HRL was
calculated in a d fferent manner than EPA's provisional HA because child exposure factors and
toxicokinetic adjustments were used to derive the provisional HA.
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Perfluorooctane sulfonic acid
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 170 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of 90% of „„„, . „ . .
99% of Detects
Detects Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Select New Jersey Water Systems
Select Minnesota municipal wells
Select Minnesota non-community wells
Select Minnesota private wells
Aggregate of above Minnesota wells
HRL Ratios (HRL/MN MW MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
23
37
22
26
85
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
13
6
0
0
6
Number of
States
%
PWSs/Sites/Sam
pies with
detects
57%
16.2%
0%
0%
7.1%
Units
States
States
States
Range of Detects
(ug/L)
0.0042-0.019
ND-1.4
ND
ND
ND-1.4
Non-cancer: 0.143
Amount Range
10-500K
0
Units
Ibs/yr
Ibs/yr
Year
2002
2003 (EPA est.)
Year
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Notes
Targeted Sampl ng 2006 - Targeted study "Determination of Perfluorooctanoic Acid (PFOA) in Aqueous Samples, Final Report." Jan 2007,
NJDEP, Division of Water Supply.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Cancer:
Estimate of zero as phased out.
Surface-active agents in aqueous media; chemical intermediate; in fire-fight ng applications, floor polish; metal plating baths; pest c de active ingred ent for ant bait traps. (HSDB)
Value
100,000
370
Units
length of time
L/kg
unitless
cm3/g
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = biodegrades sometimes/recalcitrant
-------
Perfluorooctanoic acid (PFOA)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 171 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perfluorooctanoic acid (PFOA)
6614
335671
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.46
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
Critical Effect
Increased maternal liver weight at term
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-Provisional HA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.4
1.1
Y/N
Y/N
ug/L
ug/L
ug/L
January 2008
Prevalence Magnitude
10 6
Scores based on supplemental data HRL Ratio(s)
NC HRL/MN MW MAX: 1.22
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data (BMDL10), Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA:
http://www.epa.goV/waterscience/criteria/d rinking/pha-PFOA_PFOS.pdf
Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf
Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). This value differs
from EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to
derive the provisional HA.
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Perfluorooctanoic acid (PFOA)
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 172 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of 90% of „„„, . „ . .
99% of Detects
Detects Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
NJDEP - Jan 2007
Little Hocking, OH Municipal Wells (FW)
Select Minnesota municipal wells
Select Minnesota non-community wells
Select Minnesota private wells
Aggregate of above Minnesota wells
HRL Ratios (HRL/MN MW MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
23
No data
37
22
26
85
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
18
6
0
1
7
Number of
States
%
PWSs/Sites/Sam
pies with
detects
78
16.2%
0%
3.8%
8.2%
Units
States
States
States
Range of Detects
(ug/L)
<0.004 - 0.039
1.5-7.2
ND-0.9
ND
ND-0.67
ND-0.9
Non-cancer: 1.22
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Notes
Targeted study ' Determination of Perfluorooctanoic Ac d (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water
Supply.
Emmett, et al., 2006. J. Occ. Env. Med. Little Hocking, OH; data from 2002-2005.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Cancer:
Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire-fight ng applications, cosmetics, greases and lubricants, pa nts, polishes and adhesives (HSDB)
Value
180
27,000
9.10E-02
1
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
PBT; BST = biodegrades sometimes/recalcitrant
-------
Permethrin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 173 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Permethrin
35815
52645531
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.25
0.05
0.05
0.2
0.05
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
1999
Critical Effect
Neurotox (aggression, abnormal/ decreased movement),
increased body temperature. Q1* 0.0096 (mg/kg/day)-1.
See CAR
ncreased liver weight
Neurol.
Cancer Data
EPA Lifetime Cancer Risk, 10"*
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0096
3
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
1991
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
1,750
3.65
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 7 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 1,944
CAR HRL/SWC EEC: 4.05
Notes
Reference Dose; Basis = NOAEL 25 mg/kg-d; UF = 100.
Reference Dose; Basis = NOEL 5 mg/kd-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level; ATSDR MRL-int.
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
EPA
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Permethrin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 174 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
1,066,056
0
17,979
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
48
0
7
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 0.9 ug/L
Ground water chronic: 0 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1,944
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 4.05
nsecticide (HSDB)
Value
178,000
6.5
1.87E-06
0.006
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF/BST
Notes
BF = biodegrades fast; BST = biodegrades sometimes/reca c trant
-------
Profenofos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 175 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Profenofos
34318
41198087
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
0.0004
0.05
162
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1990
Critical Effect
Inhibition of plasma & RBC ChE activity
Blood - other changes, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - true
cholinesterase
Behavioral - somnolence (general depressed activity),
Behavioral - tremor, Gastrointestinal - changes in structure
or function of salivary glands
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.35
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 3.5
Notes
Reference Dose; Basis = NOEL 0.005 mg*g-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 12,781,1987
Supplemental Data
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959- Volume(issue)/page/year 73,16,1984
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Profenofos
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 176 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
879,776
0
255
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
14
0
1
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 0.1 ug/L
Non-cancer: 3.5
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Ground water chronic: 0.03 ug/L
Cancer:
Pesticide, insecticide, acaricide (HSDB)
Value
4.68
2.21 E-08
28
9
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = biodegrades sometimes/recalcitrant; PBT
-------
Quinoline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 177 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Quinoline
3467
91225
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.001
3
B2
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
2001
2001
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
0.01
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
L?-L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
IRIS
IRIS
Hirao et al., 1976; oral study in rats
CACART, EPA, RAIS
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Quinoline
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 178 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
62
28,629
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
8
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical intermed ate; pharmaceutical (anti-malarial); flavoring (HSDB)
Value
1,837
2.03
1.67E-06
6,110
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = Biodegrades Fast with Acclimation
-------
RDX
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 179 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
RDX
5404
121824
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.003
0.003
0.003
0.03
40
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1988
2006
6/1995
Critical Effect
nflammation of the prostate.
Cardiac - other changes, Blood - pigmented or nucleated
red blood cells, Biochemical - Enzyme inhibition, induction,
or change in blood or tissue levels - transaminases
Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.03
0.11
c
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1988
1988
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
21
0.3
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Teratogen
Prevalence Magnitude
5 5 Li
HRL Ratio(s)
NCHRL/STORET90%: 0.092
CARHRL/STORET90%: 0.0013
Notes
Reference Dose
Reference Dose; Basis NOEL 0.3 mg/kg-d. U.S. DOD, 1983
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in rat; NTIS National Technical Information Service.
(Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year AD-A092-531
Supplemental Data
EPAHA
EPA; RAIS
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
RDX
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 180 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental water data
STORE!
HRL Ratios (HRL/STORET 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1E, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
n
PWSs/Sites/Sa
mples
23
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
23
Number of
States
%
PWSs/Sites/Sam
pies with
detects
100
Units
States
States
States
Minimum value of
Detects
15
Non-cancer: 0.092
Amount Range
>500K - 1 M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
270
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
140
90% of
Detects
229
Units
ug/L
Cancer: 0.0013
Notes
High explosive
Value
195.4
0.87
6.30E-08
59.7
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = biodegrades fast with acclimation
-------
sec-Butyl benzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 181 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
sec-Butylbenzene
5904
135988
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
4.42
2,240
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Behavioral -alteration of classical conditioning
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
10.3
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
3 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 1.03
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 24-week oral rat study; VCVGH "Vrednie chemichescie
veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated
hydrocarbons) Bandman A.L. etal., Chimia, 1990. Volume(issueXpage/year -,179,1990
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
sec-Butyl benzene
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 182 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
12,343
22,974
28
34
0.227
0.148
0.03
0.1
19.8
22
0.7
0.6
10
4.6
19.8
22
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309
Amount
Released
# PWSs/Sites
sampled
25
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0.58
Number of
States
% PWSs/Sites
with detects
0.005
Units
States
States
States
Minimum value of
Detects
Non-cancer: 1.03
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
11
Year
Maximum
value of
Detects
0.39
2.81
11
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Solvent for coating compositions, organic synthesis, plasticizer, and surface active agents (HSDB)
Value
15
7,200
4.57
1.80E-02
17.6
15
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = biodegrades slowly
-------
Strontium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 183 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Strontium
18848
7440246
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.6
0.6
0.6
2
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1992
2006
2004
Critical Effect
Rachitic bone
Musculo-skeletal effects
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
D
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
1993
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
20
4,200
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude
10 10 Li
HRL Ratio(s)
NCHRL/NIRS90%:3.88
Notes
Reference Dose
Reference Dose; Storey, 1961 ; Marie et al., 1985; Skoryna, 1981; UF = 300; Rat; Basis NOAEL = 190
mg/kg-d
Reference Dose
Reference Dose; IRIS
Minimal Risk Level; UF = 30; MRL-Int
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Strontium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 184 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
980
99.1
1.5
43,550
178
1,080
7,340
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 3.88
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data are for strontium carbonate: In pyrotechnics; steel production; catalyst; lead scavenger (HSDB); naturally-occurring
Value
11
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BST
Notes
assumed persistent; All use and env. fate data are for strontium carbonate; BST = biodegrades sometimes/recalcitrant
-------
Tebuconazole
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 185 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tebuconazole
69191
107534963
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.029
0.03
1,000
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2008
1994
Critical Effect
Decreased body weights, absolute brain weights, brain
measurements and motor activity in offspring
Behavioral - food intake (animal)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
C
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
2008
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
210
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
96 L' L
HRL Ratio(s)
NC HRL/GWC EEC: 9.09
Notes
Reference Dose; Basis = LOAEL 8.8 mg/kg-d; UF = 300. Federal Register: May 14, 2008 (Volume
74, Number 94), pp 27748-27756.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Oral study- rabbit; NTIS Nationa Technical Information Service. (Springfield, VA 22161) Formerly U.S.
Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0545183
OPP; 73 FR No. 94, pp 27748-27756.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Tebuconazole
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 186 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
478,568
Units
Ibs/yr
Ibs/yr
Ibs/yr
Number of
States
16
Units
States
States
States
Year
1997
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 14 ug/L
Ground water chronic: 23.1 ug/L
HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 9.09
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
Fungicide (HSDB)
Value
3.7
1.45E-10
36
9
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
PBT; BST = biodegrades sometimes/recalcitrant
-------
Tebufenozide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 187 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tebufenozide
69514
112410238
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.018
0.02
8.7
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
2003
Critical Effect
Growth retardation, alterations in hematology
parameters, changes in organ weights, and
histopathological lesions in the bone, spleen and liver
Effect on erythrocytes, periferal hemolytic anaemia. Gross
and histopathologica lesions in the spleen (congestion,
pigment, and extra-medullary haematopoiesis)
Blood - normocytic anemia, Blood - thrombocytopenia
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
126
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
9 5 Li
HRL Ratio(s)
NC HRL/SWC EEC: 8.4
Notes
Reference Dose; Basis NOAEL = 1 .8 mg/kg-d, UF = 100. Federal Register 64 FR, No. 203, pp
56690-56697, October 21, 1999.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1-year study in dog; FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year 64, 16851, 1999
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Tebufenozide
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 188 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
104,413
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
17
Units
States
States
States
Year
1997
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 15 ug/L
Ground water chronic: 1.19ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.4
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
nsecticide (HSDB)
Value
4.25
1.26E-08
0.83
11
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
PBT; BST = biodegrades sometimes/recalcitrant
-------
Tellurium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 189 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tellurium
23035
13494809
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
25
20
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Maternal toxicity
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
175
Y/N
Y/N
ug/L
ug/L
Teratogen
Prevalence Magnitude
49 Li
HRL Ratio(s)
NCHRL/NIRS 90%: 0.673
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; No Observed Effect Leve ; Johnson et al., 1988
Lowest Observed Adverse Effect Level
Supplemental Data
Mouse; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure,"
Izmerov, N.F., et al., Moscow, Centre of Internatonal Projects, GKNT, 1982 Volume(issue)/page/year -
,107,1982
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Tellurium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 190 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
4
0.4
15
370
22
260
360
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.673
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data are for sodium tellurite: Bacteriology, medicine (HSDB); naturally-occurring
Value
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L
Degradation
Code
BST
Notes
assume persistent; All use and env. fate data are for sodium tellurite; BST = biodegrades sometimes/recalcitrant
-------
Terbufos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 191 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Terbufos
22585
13071799
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
0.00005
0.000025
0.0002
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2006
1989
Critical Effect
Plasma ChE inhibition
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
D
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
1988
Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.002
0.35
Y/N
Y/N
mg/L
ug/L
ug/L
2006
Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NC HRL/NAWQA 90% : 1.67
Notes
Reference Dose; Basis = NOAEL 0.005 mgrtsg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for
potency scoring.
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.
-------
Terbufos
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 192 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300
0
0
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T,,2, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118
Amount
Released
6,515,603
n
PWSs/Sites/Sa
mples
n
PWSs/Sites/Sa
mples
61
915
22
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
#with Detects
0
11
0.31
Number of
States
37
%
PWSs/Sites/Sam
pies with
detects
0
0
%
PWSs/Sites/Sam
pies with
detects
0
1.2
0.0021
Units
States
States
States
Minimum value of
Detects
Minimum value of
Detects
0.1
Non-cancer: 1.67
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.56
Year
1997
Maximum value
of Detects
Not Detected
Not Detected
Maximum value
of Detects
3.2
0.017
0.21
0.56
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes
Median value of
Detects
Median value of
Detects
0.185
95% of Detects
Not Detected
Not Detected
90% of Detects
0.202
Notes
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:
Pesticide Pilot Mentoring Program (USGS/EPA)
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
nsecticide (HSDB)
Value
38
500-5,000
4.48
2.40E-05
5.07
14
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
BSA = biodegrades slowly with acclimation
-------
Terbufos sulfone
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 193 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Terbufos sulfone
37071
5607016
Attribute Scores
Potency Severity
7 3
Prevalence Magnitude
1 1
Scores based on parent Scores based on parent
HEALTH EFFECTS DATA1 - See parent Terbufos
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Plasma ChE inhibition
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
0.35
Y/N
Y/N
ug/L
ug/L
3-model Categorical Prediction
NL
HRL Ratio(s)
NC HRL/NAWQA 90% : 1 .67 (NAWQA data and HRL
for parent terbufos)
Notes
Reference Dose - FOR PARENT TERBUFOS
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
Drinking Water Equivalent Level
Based on data for parent terbufos
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.
-------
Terbufos sulfone
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 194 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Finished Water Occurrence Data FOR TERBUFOS - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300
0
0
0
0
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Not Detected
Not Detected
Not Detected
Not Detected
Not Detected
Ambient Water Occurrence Data FOR TERBUFOS - PARENT
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
FOR TERBUFOS - PARENT
CAL DHS
STORE!
PPMP finished water
PPMP ambient water
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118
Amount
Released
n
PWSs/Sites/Sa
mples
61
915
22
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
11
2
0
0.31
Number of
States
%
PWSs/Sites/Sam
pies with
detects
0
1.2
0.9
0
0.0021
Units
States
States
States
Minimum value of
Detects
0.1
Non-cancer: 1.67
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
0.56
Year
Maximum value
of Detects
3.2
0.016
0.017
0.21
0.56
Units for Mag
data
ug/L
mg/L
mg/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
0.185
90% of Detects
0.202
Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
Cancer:
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx
Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O-
ANALOGUE SULFONE
Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O-
ANALOGUE SULFONE
NAWQA data and HRL for Parent Terbufos
Pesticide degradate
Value
38
2.21 E-08
21
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with ace mation
-------
Thiodicarb
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 195 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Thiodicarb
38116
59669260
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.03
0.03
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1998
2000
Critical Effect
Extramedulary hematapoesis and decreased red blood cell
cholinesterase activity
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0188
B2
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
210
1.86
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 6 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 8.1
CAR HRL/SWC EEC: 0.07
Notes
Reference Dose; Basis NOEL = 3.3 mg/kg-d (males) and 4.5 mg/kg-d (females); UF = 100; chronic rat
study.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
CACART; EPA
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Thiodicarb
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 196 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
821,267
0.05
1,430
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
27
1
3
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 26 ug/L
Ground water chronic: 0 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.1
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.07
nsecticide (HSDB)
Value
1.7
9.33E-07
35
36
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
-------
Thiophanate-methyl
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 197 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Thiophanate-methyl
27753
23564058
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.08
0.08
0.08
0.08
1.2
2,270
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2004
1986
1998
Critical Effect
Thyroid and liver effects and decreased body weight
Decreased body weight, decreased spermatogenesis and
histological evidence of hyperthyroidism
Endocrine - evidence of thyroid hypofunction, Endocrine -
changes in thyroid weight, Nutritional and Gross Metabolic
- weight loss or decreased weight gain
Sense Organs and Special Senses (Eye) - mydriasis
(pupillary dilation), Behavioral - somno ence (general
depressed activity), Behavioral - convulsions or effect on
seizure threshold
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0116
C
mg/L
(mgftg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
560
3.02
Y/N
Y/N
ug/L
ug/L
Female & male reproductive toxicity
Prevalence Magnitude , „ ,
10 6 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 45.9
CAR HRL/SWC EEC: 0.248
Notes
Reference Dose; Basis NOEL = 8 mg/kg-d; UF = 100; chronic dog study.
Reference Dose; Basis = NOEL 8 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; FEREAC Federal Register. (U.S. Government Printing Office,
Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 67,14944,2002
Supplemental Data
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959- Volume(issue)/page/year 23,606,1972
OPP
EPA
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Thiophanate-methyl
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 198 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
453,792
0
92
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
40
0
3
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 12.2 ug/L
Ground water chronic: 3.03 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 45.9
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.248
Fungicide (HSDB)
Value
14.32
1.4
2.94E-13
438.9
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BF
Notes
BF = biodegrades fast
-------
Toluene diisocyanate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 199 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Toluene diisocyanate
29421
26471625
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD501
CTDJPN Lowest Oral LD501
RTECS Lowest Oral LD501
Value
30
85.7
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Burns throat immediately.
Related to Chronic Data - death
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.039
2B
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
1999
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
210
0.9
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,
10 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series.
(Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-251,1986
Supplemental Data
Applies to m ixture of 2,4- and 2,6- isomers.
CACART; IARC; OEHHA
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Toluene diisocyanate
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 200 of 214
OCCURRENCE DATA
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
1
129,143
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
1
31
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>500M - 1 B
>500M - 1 B
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
n plastics manufacture (NTP)
Value
9,114
3.74
1.11E-05
37.57
17
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
-------
Tribufos
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 201 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tribufos
2814
78488
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001
0.00003
0.00003
4.08
77
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1988
Critical Effect
Plasma ChE inhibition
Gastrointestinal - other changes, Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels -
other hydrolases, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - peptidases
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
7
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
98 Li
HRL Ratio(s)
NC HRL/SWC EEC: 3.89
Notes
Reference Dose; Basis = NOAEL 0.1 mg/kg-d; UF = 100.
Reference Dose; Basis NOAEL 0.1 mg/kg-d; Abou-Donia etal., 1979
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 43 week study in rodent; FATOAO Farmakologiya i Toksikologiya
(Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.2- 1939- Volume(issue)/page/year 38,96,1975
Supplemental Data
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986 Volume(issue)/page/year -,1188,1986
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Tribufos
CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
EPA-OGWDW
August 2009
Page 202 of 214
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
Amount
Released
4,918,265
4
7
n
PWSs/Sites/Sa
mples
OPP Estimated Environmental Concentration
Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0
Number of
States
16
1
1
%
PWSs/Sites/Sam
pies with
detects
0
0
Units
States
States
States
Minimum value of
Detects
Year
1997
2004
2004
Maximum
value of
Detects
Surface water chronic 1.8ug/L
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
95% of
Detects
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)
Ground water chronic 0 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 3.89
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer:
nsecticide; cotton defoliant (HSDB)
Value
1,888
5.7
2.94E-07
2.3
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
code
BF
Notes
BF = biodegrades fast
-------
Triethylamine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 203 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Triethylamine
5379
121448
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
1
460
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
Critical Effect
Brain and Coverings - other degenerative changes
Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
2.33
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude
10 9
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-week oral rat study; WDZAEK Weisheng Dulixue Zazhi.
Journal of Health Toxicology. (Weisheng Du ixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai,
Beijing, Peop. Rep. China) V.1- 1987 Volume(issue)/page/year 4,45,1990
Supplemental Data
AMIHBCAMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU. Volume(ssue)/page/year 4,119,1951
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Triethylamine
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 204 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
12,000
1,167,219
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
14
35
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
>10M-50M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Chemical intermed ate; stabilizer; in herbicides/pest c des; in consumer products; food addit ve; photographic chemical; in carpet c eaners (HSDB)
Value
107.2
1.45
1.49E-04
73,700
46
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BSA
Notes
PBT; BSA = biodegrades slowly with acclimation
-------
Triphenyltin hydroxide (TPTH)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 205 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Triphenyltin hydroxide (TPTH)
2738
76879
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0003
0.0005
0.15
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999
1970
Critical Effect
Decreased white blood cells
Blood - changes in other cell count (unspecified), Blood -
changes in leukocyte (WBC) count
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
18.3
B2
mg/L
(mg/kg-d)-'
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
2.1
0.0019
Y/N
Y/N
ug/L
ug/L
Teratogen; Developmental
Prevalence Magnitude
10 6
HRL Ratio(s)
NC HRL/SWC EEC: 0.33
CAR HRL/SWC EEC: 0.0003
Notes
Reference Dose; OPP RED
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in guinea pig; FCTXAV Food and Cosmetics
Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year4,35,1966
Supplemental Data
EPA; CACART
UMD; CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.
-------
Triphenyltin hydroxide (TPTH)
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 206 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
660,971
0
0
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
26
0
0
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic 6.4 ug/L
Ground water chronic 0 ug/L
Notes
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.33
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.0003
Pesticide (NTP)
Value
2,000
3.53
4.26E-07
0.4
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
Notes
-------
Urethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 207 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Urethane
2189
51796
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.9
78
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2005
Critical Effect
Decreased survival
Liver - changes in liver weight, Kidney, Ureter, Bladder -
changes in bladder weight, Blood - changes in leukocyte
(WBC) count
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
1
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
6.3
0.035
Y/N
Y/N
ug/L
ug/L
Developmental
Teratogen
Prevalence Magnitude ,
7 6 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; Food and Chemical Toxicology 43 (2005) 1-19
Lowest Observed Adverse Effect Level; 1 3 week oral study in rats; NTPTR National Toxicology Program
Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NIH-96-
3937
Supplemental Data
Vol. 7, Suppl. 7; 1987
IARC; CACART; OEHHA
UMD
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Urethane
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 208 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
0
96,050
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
0
7
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer:
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
2004
2004
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Paint ingredient (NTP)
Value
-0.15
6.40E-08
480,000
40
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BS
Notes
PBT; BS = Biodegrades Slowly
-------
Vanadium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 209 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Vanadium
18882
7440622
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.007
0.003
1.8
960
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1992
2001
Critical Effect
Minor renal effects (altered renal function as indicated
by increased plasma urea, and mild histological
changes).
Kidney lesions and increases in plasma urea and uric acid
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
21
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude , „ ,
10 8 Li L
HRL Ratio(s)
NCHRL/NIRS90%:0.913
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; HEAST
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; IOM 2001 Dietary Reference ntakes
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; Domestic mammal
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Vanadium
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 210 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
989
146
14.76
3.1
70.4
7.27
23
45
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Amount
Released
# PWSs/Sites
sampled
Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
Number of
States
% PWSs/Sites
with detects
Units
States
States
States
Minimum value of
Detects
Non-cancer: 0.913
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Year
Maximum
value of
Detects
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Median value of
Detects
99% of
Detects
Units for Mag
data
Cancer:
Notes
Use data are for vanadium pentoxide: Chemical intermediate; catalyst; (HSDB); naturally-occurring
Value
8,000
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
assumed persistent; All use and env. fate data are for vanad um pentoxide; BST = biodegrades sometimes/recalcitrant
-------
Vinclozolin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 211 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Vinclozolin
35005
50471448
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.012
0.025
0.025
0.01
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986
1995
Critical Effect
Histopathological les ons in the lungs, iver, ovaries &
eyes. Q1 * 0.0638 (mg/kg-day)-1 .Group C. See CAR
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0638
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
84
0.549
Y/N
Y/N
ug/L
ug/L
Developmental
Prevalence Magnitude , „ ,
10 5 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 8.94
CAR HRL/SWC EEC: 0.058
Notes
Reference Dose; Basis = NOAEL 1 .2 mg/kg-d; UF = 1 00.
Reference Dose; Basis = NOEL 2.5 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data
EPA
CACART
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
-------
Vinclozolin
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 212 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
121,959
0
0
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
26
0
0
Units
States
States
States
Year
1997
2004
2004
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 9.4 ug/L
Ground water chronic: 0 ug/L
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.94
Amount Range
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Cancer: 0.058
Fungicide (HSDB)
Value
289
3.1
1.33E-08
2.6
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BST
Notes
BST = biodegrades sometimes/recalcitrant
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Ziram
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 213 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ziram
5947
137304
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.016
0.003
1.6
1
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1996
Critical Effect
Decreased body weight gain
Decreased body weight
Gastrointestinal - hypermotility, diarrhea
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0611
Suggestive (not
quantified)
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
112
0.57
Y/N
Y/N
ug/L
ug/L
Prevalence Magnitude ,
10 7 L
HRL Ratio(s)
NC HRL/SWC EEC: 56.6
CAR HRL/SWC EEC: 0.288
Notes
Reference Dose; Basis = NOAEL 1 .6 mg/kg-d; UF = 1 00.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake; Group ADI for Ferbam and Ziram
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
OPP
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 17,3155,1992
Supplemental Data
Drinking Water Equivalent Level
1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.
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Ziram
CCL 3 Contaminant Information Sheet
EPA-OGWDW
August 2009
Page 214 of 214
OCCURRENCE DATA1
# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Amount
Released
1,992,552
Units
Ibsfyr
Ibs/yr
Ibs/yr
Number of
States
29
Units
States
States
States
Year
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Notes
National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
Supplemental Water Data
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Surface water chronic: 1 .98 ug/L
Non-cancer: 56.6
Amount Range
>500K - 1 M
>500K - 1 M
Units
Ibs/yr
Ibs/yr
Year
1998
2002
Ground water chronic: 0.03 ug/L
Cancer: 0.288
Synthetic rubber chemical (NTP); fungicide
Value
6.20E-10
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L
Degradation
Code
BFA
Notes
BFA = Biodegrades Fast with Acclimation
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