vvEPA
   United States
   Environmental Protection
   Agency
Contaminant Information Sheets for the
Final CCL 3 Chemicals

-------
Office of Water (4607M)
EPA815-R-09-012
August 2009
www.epa.gov/safewater

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EPA815-R-09-012                     Final CCL 3 Chemicals                                 August 2009
EPAOGWDW                      Contaminant Information Sheets                             Page 1 of 214

             Contaminant Information Sheets for the Final CCL 3 Chemicals

This File contains Contaminant Information Sheets for 106 chemical contaminants that are listed
on the final third Contaminant Candidate List (CCL 3).  (Note: there are 104 chemical entries
listed in the Federal Register Notice for the final CCL 3; cyanotoxins are listed as a group. In this
file, there are information sheets on three individual cyanotoxins that were evaluated in the CCL
3 process (Anatoxin-a, Cylindrospermopsin, and Microcystin-LR)).  These sheets summarize
information about the chemicals that were considered during the development of the CCL 3. The
sheets are in alphabetical order.  Each information sheet is two pages in length. There is an
index/bookmark in this PDF file that can be used to negotiate the file.  The bookmarks are
hyperlinked.  You can find the contaminant name in the bookmark list, click on it, and the
hyperlink will take you to that file.

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EPA815-R-09-012                          Final CCL 3 Chemicals                                       August 2009
EPA OGWDW                          Contaminant Information Sheets                                  Page 2 of 214
                     This page intentionally left blank for double-sided printing

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1,1,1,2-Tetrachloroethane
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
 August 2009
Page 3 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,1,1 ,2-Tetrachloroethane
9105
630206
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.03
0.03
0.03












Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987
2006













Critical Effect

Mineralization of the kidneys in males, hepatic clear cell
change in females














Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.1
0.026

C
3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1


1989


1989
1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y

1
210
1
Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude , „
36 L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 67.7
CAR HRL/NCOD R1 90%: 0.323
Notes
Reference Dose
Reference Dose; Basis LOAEL = 89.3 mg/kg-d (NTP 1983)
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










EPA; RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLswere calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.

-------
    1,1,1,2-Tetrachloroethane
    CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
 August 2009
Page 4 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

16,956
24,127


31
51


0.18
0.21


0.06
0.2


9.2
18


0.59
0.5


3.1
1.55


9.2
18

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309


Amount
Released

36
12,088
# PWSs/Sites
sampled

4


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

0.09


Number of
States

2
7
% PWSs/Sites
with detects

0.011


Units
States
States
States
Minimum value of
Detects

Non-cancer: 67.7
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.0644


Year
2004
2004

Maximum
value of
Detects

0.0275


0.0644


0.0644


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer: 0.323



Notes





Chemical intermed ate (NTP)
Value
60
93-399
2.66

2.70E-03
1,100
22
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
PBT; BST = biodegrades sometimes/recalcitrant







-------
1,1-Dichloroethane
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
 August 2009
Page 5 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
1,1-Dichloroethane
2647
75343
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.2












Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date



2001












Critical Effect



Decreased body weight gain












Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


0.0057
C

mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1990






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

1,400
6.14
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
77 Li
HRL Ratio(s)
NC HRL/NCOD R1 90%: 250
CAR HRL/NCOD R1 90%: 1.1
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; basis NOAEL 71 4 mg/kg-d, UF = 3,000; Muralidhara, et al, 2001 .
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










OEHHA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   1,1-Dichloroethane
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
 August 2009
Page 6 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

20,483
24,808


233
184


1.14
0.74


0.01
0.0013


500
159


1.2
1


5.6
3.8


27
25

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,350


Amount
Released

63
17,368
# PWSs/Sites
sampled

135


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

3.103


Number of
States

3
5
% PWSs/Sites
with detects

0.008


Units
States
States
States
Minimum value of
Detects

Non-cancer: 250
Amount Range
>1M-10M
>500K - 1 M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



39


Year

2004
2004
Maximum
value of
Detects

0.05


0.316


5.6


Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer: 1.1



Notes





Solvent (NTP)
Value
38
30
1.79

5.62E-03
5040
46
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = Biodegrades Slowly with Acclimation







-------
1,2,3-Trichloropropane
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
 August 2009
Page 7 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1 ,2,3-Trichloropropane
3817
96184
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.006
0.006
0.006
0.06





5.71
22.9




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987
2006

1992





1987





Critical Effect

Alterations in clinical chemistry & reduction in RBC mass


Hepatic






Kidney, Ureter, Bladder - changes in bladder weight, Blood
- changes in serum composition (e.g. TP, bilirubin,
cholesterol), Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - other esterases




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

7



mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y

0.2
42
0.005
Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude
3 6 Li
HRL Ratio(s)
NC HRL/NCOD R2 90%: 2.1
CAR HRL/NCOD R2 90% : 0.00025
Notes
Reference Dose
Reference Dose; NTP, 1983 ; rats; UF = 1,000; Basis NOAEL = 8 mg/kg-d
Reference Dose; F' 89
Reference Dose
Minimal Risk Level; Int-MRL; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; ITER NOAEL
Lowest Observed Adverse Effect Level; 1 7 week oral study in rats; NTPTR National Toxicology Program
Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-
TR-384,1993
Supplemental Data





HEAST




CACART, RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   1,2,3-Trichloropropane
   CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
 August 2009
Page 8 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

17,392
24,088


44
19


0.25
0.079


0.1
0.03


112
3,000


0.92
0.5


6
20


112
3,000

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
4,309


Amount
Released

282
9,053
43


Units
Ibs/yr
Ibs/yr
Ibs/yr
1.0


Number of
States

1
2
0.05


Units
States
States
States
2.92


Year

2004
2004
0.4


0.97


2.92


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Supplemental Water Data
Nominated data from NJDEP

HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
NJ study: Detected in excess of health-based drinking water guidance value in 30 of 2,640 private wells and 11 of approximately 260 community
water systems between 1999 and 2004 in NJ SOC Waiver Program sampling.

Non-cancer: 2.1
Amount Range
>10M-50M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.00025



Notes






Paint ingredient (NTP)
Value
38
77-95
2.27

3.43E-04
1,750
25
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
1,3-Butadiene
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
 August 2009
Page 9 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,3-Butadiene
4578
106990
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude
10 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


3.4
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-'






1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.0103
Y/N
Y/N

ug/L
ug/L






Teratogen List




3-model Categorical Prediction
L
HRL Ratio(s)
No Water Data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data








Vol.71; 1999

EPA, IARC, CACART, OEHHA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   1,3-Butadiene
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 10 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

493
1,964,956
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

8
34
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Rubber chemical (NTP)
Value
7-28
288
1.99

7.40E-02
735

Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = biodegrades fast with acclimation







-------
1,3-Dinitrobenzene
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 11 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,3-Dinitrobenzene
4045
99650
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.0001
0.0001
0.0001
0.0005






1.73




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1988
2006

1995











Critical Effect

Increased spleen weight


Hemato.






Endocrine - changes in spleen weight, Blood -
methemoglobinemia-carboxyhemoglobin




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)-1
(mg/kg-d)"1





1991






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y
0.005
0.7

Y/N
Y/N
mg/L
ug/L
ug/L


2006



male



Prevalence Magnitude
1 8 NLi
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; Cody etal., 1981; Rats; UF = 3,000; Basis NOAEL = 0.4 mg/kg-d
Reference Dose
Reference Dose; IRIS
Minimal Risk Level; Int-MRL; UF = 1 ,000
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90 day oral study in rats; TOXID9 Toxicologist. (Soc. of
Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year
30,200,1996
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   1,3-Dinitrobenzene
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 12 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

2
528,962
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
1
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





ndustrial chemical (HSDB)
Value
38
150
1.49

4.90E-08
533
37
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
1,4-Dioxane
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 13 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
1,4-Dioxane
5539
123911
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value




0.1











Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.3
0.011
0.027
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-1

1999
1987


1987






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

700
3
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
9 8 L
HRL Ratio(s)
NC HRL/CAL DHS 90%: 92.1
CAR HRL/CAL DHS 90%: 0.395
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; ATSDR MRL-int = 0.6 mg/kg-d
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










CACART; EPA; IARC; OEHHA; RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   1,4-Dioxane
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
  August 2009
Page 14 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental water data
CAL DHS

HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler


Amount
Released

89,521
821,067
n
PWSs/Sites/Sa
mples
869


Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
89


Number of
States

7
22
%
PWSs/Sites/Sam
pies with
detects
10.2


Units
States
States
States
Minimum value of
Detects
0.001

Non-cancer: 92.1
Amount Range
>1M-10M
>1M-10M
Solvent (NTP); so
Value

1
-0.27

4.80E-06
1,000,000

Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year

2004
2004
Maximum
value of
Detects
46.2






Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
2.1
90% of
Detects
7.6
Units
ug/L

Cancer: 0.395



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





vent stabilizer
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
BS = biodegrades slowly







-------
17 alpha-Estradiol
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 15 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
17 alpha-Estradio
81747
57910
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
9 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormonal response in post-menopausal
women










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.35

Y/N
Y/N
mg/L
ug/L
ug/L










3-model Categorical Prediction
L?
HRL Ratio(s)
NC HRL/Kolpin MAX: 4.7
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   17 alpha-Estradiol
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 16 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, et al., 2002

HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released


n
PWSs/Sites/Sa
mples
70






Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects







Number of
States


%
PWSs/Sites/Sam
pies with
detects
5.7






Units
States
States
States
Minimum value of
Detects


Non-cancer: 4.7
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year


Maximum
value of
Detects
0.074
















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
0.03

90% of
Detects


Units for Mag
data
ug/L
Notes
National Surface Water Reconnaissance
Kolpin, D.W., et al., 2002. Env. Sci. STechnol., 36(6), pp. 1202-1211.

Cancer:







Pharmaceutical, hormone
Value
38

3.94


3.9
11
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slowly with acclimation







-------
1-Butanol
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 17 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
1-Butanol
2563
71363
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.1

0.1







0.2




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987














Critical Effect

Hypoactivity, ataxia









Behavioral - somnolence (general depressed activity)




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)"1
(mg/kg-d)"1





1991






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

700

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude , „ ,
10 10 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; U.S. EPA, 1986; Basis NOAEL = 125 mg/kg-d, UF = 1,000; oral study in rats.
Reference Dose
Reference Dose; IRIS
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30 day oral study in rats; TOLED5 Toxicology Letters. (Elsevier
Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year
135,3122,2002
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   1-Butanol
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 18 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released

22,011
17,648,846
# PWSs/Sites
sampled






Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects






Number of
States

20
44
% PWSs/Sites
with detects






Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year

2004
2004
Maximum
value of
Detects
















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Paint solvent; chemical intermediate; food additive (HSDB)
Value

2.443
0.88

8.82E-06
63200

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades Fast







-------
2-Methoxyethanol
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 19 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
2-Methoxyethanol
4803
109864
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.003












Units
mg/kg-d
mg/kg-d
mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect



Reproductive effects












Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

21

Y/N
Y/N

ug/L
ug/L






Teratogen / developmental, male



Prevalence Magnitude
9 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Unpublished NTP study - Gulati, et al, 1990.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data











UMD / CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   2-Methoxyethanol
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 20 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

14,390
153,774
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

3
16
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>10M-50M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Consumer products; synthetic Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin Lot on (NTP)
Value

1
-0.77

3.30E-07
1000000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = Biodegrades Fast with acclimat on







-------
2-Propen-1-ol
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 21 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
2-Propen-1-ol
4596
107186
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.005

0.005







2.5



52
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987














Critical Effect

Impaired renal function & increased relative liver,
spleen & kidney weights









Liver - liver function tests impaired, Blood - changes in
serum composition (e.g. TP, bilirubin, cholesterol),
Biochemical - Metabolism (Intermediary) - Plasma proteins
not involvinq coaqulation



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



35

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
8 8 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; Carpanini et al., 1978; Rat; UF = 1,000; Basis NOAEL = 4.8 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; Rat; VCVGK "Vrednie chemichescie veshestva, galogen I
kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,121,1994
Supplemental Data


Rabbit; NTIS National Technical Information Serv ce. (Springfield, VA 22161) Formerly U.S.
Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0571508









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   2-Propen-1-ol
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 22 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

10,971
604,872
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

4
13
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Manufacture of flavorings, perfumes; chemical intermediate (HSDB)
Value

1.325
0.17

5.00E-06
1,000,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
3-Hydroxycarbofuran
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 23 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
3-Hydroxycarbofuran
25541
16655826
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00006














7
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
Inhibition of brain cholinesterase in pups - The RfD for
the parent covers the toxicity of the metabolite














Decreased body wt.
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.42

Y/N
Y/N

W/L
W/L










Prevalence Magnitude
2 7 Li
HRL Ratio(s)
NC HRL/NCOD R2 90%: 0.191
Notes
Reference Dose; Basis = BMDL10 0.03 mg/kg-d; UF = 500.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


PCBPBS Pesticde Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1971- Volume(issue)/page/year 3,435,1973









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   3-Hydroxycarbofuran
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                             EPA-OGWDW
  August 2009
Page 24 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


12,700



18



0.14



1



66.3



2.2



2.2



66.3

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water

HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,539



Amount
Released


n
PWSs/Sites/Sa
mples


1



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
1
0.022



Number of
States


%
PWSs/Sites/Sam
pies with
detects
0
0.4
0.07



Units
States
States
States
Minimum value of
Detects



Non-cancer: 0.191
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.07



Year


Maximum
value of
Detects
0
0.062
0.07



0.07



0.07



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects


95% of
Detects


Units for Mag
data
ug/L
ug/L

Cancer:



Notes







Pesticide degradate
Value
38





43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = Biodegrades Slowly with Acclimation







-------
4,4'-Methylenedianiline
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
  August 2009
Page 25 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
4,4'-Methylenedianiline
4202
101779
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value




0.08






4.34




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date




1998











Critical Effect




ntense liver degenerative lesions, hyperplasia of the
stroma






Liver - fatty liver degeneration, Kidney, Ureter, Bladder -
interstitial nephritis, Blood - normocytic anemia




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.25
1.6

2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1






1987





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


560
0.022
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,
7 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1 5 week oral study in dogs; JJATDK JAT, Journal of Applied
Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year 11,367,1991
Supplemental Data





Slope factor withdrawn


Vol. 39, Suppl. 7; 1987

IARC, CACART, OEHHA, RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   4,4'-Methylenedianiline
   CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 26 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

96,446
168,919
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

2
10
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical intermed ate; corrosion nhibitor; curing agent for polyurethanes (HSDB)
Value

4,950
1.59

1.58E-11
1,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
Acephate
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 27 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acephate
31325
30560191
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0012
0.004

0.004

0.03





10




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1989



1990










Critical Effect
Brain ChE inhibition










Brain and Coverings - other degeneratve changes,
Autonomic Nervous System - sympathomimetic,
Biochemical - Metabolism (Intermediary) - amino acids
(including renal excretion)




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.4
0.0087

C

mg/L
(mg/kg-d)"1
(mg/kg-d)-1





1988




Liver

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


8.4
4
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 7 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 1.17
CAR HRL/SWC EEC: 0.556
Notes
Reference Dose; Basis = NOAEL 0.12 mg/kg-d; UF = 100.
Reference Dose; Basis = LOEL females = 0.15 mg/kg-d; LOEL males = 0.12 mg/kg-d; Adjusted Basis
Value = LOAEL 0.0004 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; ENVRAL Environmental Research. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1967- Volume(ssue)/page/year 43,342,1987
Supplemental Data










EPA; RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Acephate
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 28 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
2,462,354
0
20,751



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
35
0
5



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 7.2 ug/L
Ground water chronic: 0.02 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.17
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.556







nsecticide (HSDB)
Value

21.8
-0.85

5.02E-13
818,000

Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
Acetaldehyde
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 29 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Acetaldehyde
2622
75070
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











10




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Behavioral - changes in motoractivity (specific assay)




Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/DBP ICR MED: 3.15
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield,
VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issueXpage/year PB234-882; 22-wk guinea pig study
Supplemental Data



Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification




B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1






1988
1999











Vol. 36, Suppl. 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative
cancer risk data were identified for potency scoring.
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

23.3

Y/N
Y/N

ug/L
ug/L






Teratogen list



IARC, EPA, CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Acetaldehyde
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
  August 2009
Page 30 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

DBF ICR




# PWSs/Sites
sampled
236




#with Detects
27




% PWSs/Sites
with detects
11.44




Minimum value of
Detects





Maximum
value of
Detects
18.3




Median value of
Detects
T.4




Mean value of
Detects
8.04




Units for Mag
data
ug/L
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
HRL Ratios (HRL/DBP ICR MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler

# Sam pies

Amount
Released

370,815
14,683,890
n
PWSs/Sites/Sa
mples
8

#with Detects

Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
3

% Samples with
detects

Number of
States

31
38
%
PWSs/Sites/Sam
pies with
detects
37.5

Minimum value of
Detects

Units
States
States
States
Minimum value of
Detects
1
Non-cancer: 3.15
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002




Maximum
value of
Detects

Year
1997
2004
2004
Maximum
value of
Detects
24

Median value of
Detects


90% of
Detects


99% of Detects

Units for Mag
data

ug/L
ug/L
ug/L

Notes





Notes


ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L


National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes



Median value of
Detects
2
90% of
Detects
4
Units for Mag
data
ug/L
Cancer:



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx




Pesticide; food additive; chemica intermediate (HSDB)
Value

1.498
-0.34

6.68E-05
1,000,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades fast (BIODEG)







-------
Acetamide
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 31 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetamide
2411
60355
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


o.or

2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-'












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.5
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
7 9 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










CACART; OEHHA; IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Acetamide
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 32 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

2,754
1,202,667
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

3
7
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Solvent; solubilizer; plasticizer; stabilizer (HSDB)
Value

5
-1.26

1.21E-08
2,250,000
39
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BF






Notes
BF = biodegrades fast







-------
Acetochlor
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 33 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor
32393
34256821
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.02

0.02







5.45




Units
mg/kg-d
mg*g-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1993














Critical Effect

Salivation, increased ALT & omithine carbamyl
transferase; increases in triglyceride & decreased blood
glucose levels; histopathological changes in kidneys &
testes









Brain and Coverings - other degenerative changes, Blood -
methemoglobinemia-carboxyhemoglobin, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - dehvdroaenases




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


140

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NC HRL/NAWQ 90% : 179
Notes
Reference Dose
Reference Dose; Basis NOAEL 2 mg*g-d; UF = 100. ICI, Inc., 1988a
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 42-day study in rat; PRKHDK Problemi na Khigienata. Problems in
Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, PI. Slaveikov 11, Sofia, Bulgaria) V.1- 1975-
Volume(issue)/page/year 15,96,1990
Supplemental Data










CACART

Drinking Water Equ valent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
        Acetochlor
        CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                                 EPA-OGWDW
  August 2009
Page 34 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615


0


0


Not Detected


Not Detected


Not Detected


Not Detected


Not Detected


Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water

CAL DHS
STORE!

HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529



Amount
Released
32,591,175

n
PWSs/Sites/Sa
mples


n
PWSs/Sites/Sa
mples
1,872
848
278



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
115
69
#with Detects
0
293
5.02



Number of
States
35

%
PWSs/Sites/Sam
pies with
detects
35.6
30.3
%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011



Units
States
States
States
Minimum value of
Detects


Minimum value of
Detects

0.026

Non-cancer: 179
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



30.4



Year
1997

Maximum value
of Detects
0.334
0.395
Maximum value
of Detects

21
0.032



0.784



8.49



Units for Mag No(es
data

ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes


Median value of
Detects


Median value of
Detects

0.022
95% of Detects
0.002
0.061
90% of Detects

1.5
Units
ug/L
ug/L
Units
ug/L
ug/L

Cancer:



Notes
Pesticide Pilot Mentoring Program (USGS/EPA)

Notes
Drinking water monitoring; http://www.cdph.ca.gov/certlic/
drinkingwater/Pages/Chemicalcontaminants.aspx






Herbicide (HSDB)
Value
4.3
98.5-239
3.03

5.4E-11
233
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast (half-life is for soil)







-------
Acetochlor ESA
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 35 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor ethanesulfonic acid (ESA)
79191
187022113
Attribute Scores
Potency Severity
5 3
Prevalence Magnitude
1 1
Scores based on parent
HEALTH EFFECTS DATA1 - See Acetochlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










23





Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










Reduced body weights and body weight gains in both
sexes





Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



161

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 205 (NAWQA data for acetochlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
      Acetochlor ESA
      CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                              EPA-OGWDW
  August 2009
Page 36 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data - FOR ACETOCHLOR - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615


0


0


Not Detected


Not Detected


Not Detected


Not Detected


Not Detected


Ambient Water Occurrence Data - FOR ACETOCHLOR - PARENT
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ACETOCHLOR ESA
POP finished water
FOR ACETOCHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529


Amount
Released
32,591,175

n
PWSs/Sites/Sa
mples
377
n
PWSs/Sites/Sa
mples
1,872
848
278


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
5
#with Detects
0
293
5.020


Number of
States
35

%
PWSs/Sites/Sam
pies with
detects
1.3
%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011


Units
States
States
States
Minimum value of
Detects
0.02
Minimum value of
Detects

0.026
Non-cancer: 205
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



30.4


Year
1997

Maximum value
of Detects
0.02
Maximum value
of Detects

21
0.032


0.784


8.49


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
FOR ACETOCHLOR - PARENT

Median value of
Detects

Median value of
Detects

0.022
95% of Detects

90% of Detects

1.5
Units
ug/L
Units
ug/L
ug/L
Cancer:



Notes
Pesticide Data Program (USD A); 2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx

NAWQA data for acetochlor - parent



Pesticide degradate
Value







Units
length of time
Ukg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Acetochlor OA
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 37 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acetochlor oxani ic acid (OA)
79193
194992444
Attribute Scores
Potency Severity
5 3
Prevalence Magnitude
1 1
Scores based on parent
HEALTH EFFECTS DATA1 - See Acetochlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










23





Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










Reduced body weights and body weight gains in both
sexes





Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



161

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 205 (NAWQA data for acetochlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR OA
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.

-------
      Acetochlor OA
      CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 38 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data FOR ACETOCHLOR - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,615



0



0



Not Detected



Not Detected



Not Detected



Not Detected



Not Detected



Ambient Water Occurrence Data FOR ACETOCHLOR - PARENT
N AWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
FRI Release - surface water
TRI Release - total
Supplemental wate data FOR
ACETOCHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
r,72, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
5,529

Amount
Released
32,591,175


n
PWSs/Sites/Sa
mples
1,872
848
278

Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
293
5.02

Number of
States
35


%
PWSs/Sites/Sam
pies with
detects
0
34.55
0.0011

Units
States
States
States
Minimum value of
Detects

0.026
Non-cancer: 205
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



30.4

Year
1997


Maximum value
of Detects

21
0.032

0.784

8.49

Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
FOR ACETOCHLOR - PARENT


Median value of
Detects

0.022
90% of Detects

1.5
Units
ug/L
ug/L
Cancer:



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx

NAWQA data for acetochlor - parent



Pesticide degradate
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Acrolein
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 39 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Acrolein
4581
107028
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.0005

0.0005
0.0005






0.5




Units
mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

2003


12/1990











Critical Effect

Decreased survival


Hemato.






Liver - liver function tests impaired, Kidney, Ureter,
Bladder - other changes




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification




3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1






1995





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



3.5

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
3 7 Li L
HRL Ratio(s)
NC HRL/NAWQA 90% : 1 .03
Notes
Reference Dose
Reference Dose; Basis = NOAEL 0.05 mg/kg-d; UF = 100. Parent, et. al, 1S92a
Reference Dose
Reference Dose (IRIS)
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26-week study in rat; VCVGK "Vrednie chemichescie veshestva,
galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,385,1994
Supplemental Data








Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Acrolein
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 40 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
1,108


Amount
Released

1
284,480
# PWSs/Sites
sampled

2


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

0.18


Number of
States

1
16
% PWSs/Sites
with detects

1.3


Units
States
States
States
Minimum value of
Detects

Non-cancer: 1.03
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



3.4


Year

2004
2004
Maximum
value of
Detects

2.35


3.4


3.4


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Aquatic herbicide; rodenticide; industrial chemical (HSDB)
Value
120-180
3
-0.01

1.22E-04
212,000

Units
hours in water
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BF






Notes
pH = 7; BF = biodegradesfast







-------
Alachlor ESA
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 41 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Alachlor ethanesulfonic acid (ESA)
71246
142363539
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










157





Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










ncreased incidence of clinical signs of toxicity in
males and females and decreased body weight gains
in males.





Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification
0.04




mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



1,100

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,,,
93 NL
Scores based on parent HRL Ratio(s)
NC HRL/NAWQA 90% : 4,300 (NAWQA data for
alachlor - parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP - FOR ALACHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data




FOR ALACHLOR - PARENT







Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.

-------
    Alachlor ESA
    CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                           EPA-OGWDW
  August 2009
Page 42 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data - FOR ALACHLOR PARENT
NAWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ALACHLOR ESA
POP finished water
POP finished water
FOR ALACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,166




Amount
Released



n
PWSs/Sites/Sa
mples
79
233
n
PWSs/Sites/Sa
mples
8,112
2,111
568




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
3
76
#with Detects
3
361
7.9




Number of
States



%
PWSs/Sites/Sam
pies with
detects
3.8
32.6
%
PWSs/Sites/Sam
pies with
detects
0.0003
17.1
0.0008




Units
States
States
States
Minimum value of
Detects
0.50
0.02
Minimum value of
Detects
0.24
0.0125
Non-cancer: 4,300
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



38.2




Year



Maximum
value of
Detects
0.50
1.44
Maximum
value of
Detects
14
10.78
0.015




0.256




3.33




Units for Mag No(es
data

ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes



Median value of
Detects


Median value of
Detects
4.29
0.06
95% of
Detects


90% of
Detects
11.09
0.55
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Pesticide Data Program (USD A); 2001
2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminant
s.aspx

NAWQA data for alachlor - parent



Pesticide degradate
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
AlachlorOA
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 43 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Alachlor oxanilic acid (OA)
79196
171262172
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
Scores based on parent
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.04




mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer




0.4
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
93 Li
Scores based on parent HRL Ratio(s)
CAR HRL/NAWQA 90% : 1 .56 (NAWQA data for
alachlor- parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data




FOR ALACHLOR - PARENT







Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   AlachlorOA
   CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                           EPA-OGWDW
  August 2009
Page 44 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data - FOR ALACHLOR PARENT
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data - FOR
ALACHLOR OA
POP finished water
POP finished water
FOR ALACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,166



Amount
Released


n
PWSs/Sites/Sa
mples
137
411
n
PWSs/Sites/Sa
mples
8,112
2,111
568



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
21
#with Detects
3
361
r.9



Number of
States


%
PWSs/Sites/Sam
pies with
detects
0.07
5.1
%
PWSs/Sites/Sam
pies with
detects
0.0003
17.1
0.0008



Units
States
States
States
Minimum value of
Detects
0.50
0.121
Minimum value of
Detects
0.24
0.0125
Non-cancer:
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



38.2



Year


Maximum
value of
Detects
0.50
0.392
Maximum
value of
Detects
14
10.8
0.015



0.256



3.33



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects


Median value of
Detects
4.29
0.06
95% of
Detects


90% of
Detects
11.09
0.55
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer: 1.56



Notes
Pesticide Data Program (USDA); 2001
2002
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx

NAWQA data for alachlor - parent



Pesticide degradate
Value







Units
ength of time
Ukg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
alpha-Hexachlorocyclohexane
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 45 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
alpha-Hexachlorocyclohexane
6535
319846
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value




0.008






1.2




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date




9/2003











Critical Effect




Hepatic






Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - hepatic microsomal mixed oxidase
(dealkylation, hydroxylation, etc.), Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels -
catalases, Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - other oxidoreductases




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0006
6.3
2.7
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


56
0.006
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
4 3 Li
HRL Ratio(s)
NC HRL/NAWQA 90% : 949
CAR HRL/NAWQA 90%: 0.102
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; Basis NOAEL 0.8 mg/kg-d; UF = 1 00.
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-day study in rat; TOLED5 Toxicology Letters. (Elsevier
Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year
56,137,1991
Supplemental Data





IRIS




EPA; RAIS; OEHHA; IARC

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   alpha-Hexachlorocyclohexane
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 46 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,113



Amount
Released


# PWSs/Sites
sampled

21



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

0.295



Number of
States


% PWSs/Sites
with detects

0.0004



Units
States
States
States
Minimum value of
Detects

Non-cancer: 949
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.21



Year


Maximum
value of
Detects

0.011



0.059



0.21



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer: 0.102



Notes





Component of benzene hexachloride (BHC) former insecticide (HSDB)
Value
1.2
641-1,995
3.8

6.70E-06
2

Units
years
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BST






Notes
hydrolysis only, pH = 7; BST = biodegrades sometimes/reca citrant







-------
Anatoxin-a
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 47 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Anatoxin-a
80772
64285069
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value








0.0005







Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date








2006







Critical Effect








Mortality







Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



3.5

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
9 8 L
Scores based on supplemental data HRL Ratio(s)
NC HRL/Cyano HABs MAX: -0.35
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis NOAEL 0.5 mg/kg-d. Astrachan, N.B. and B.G. Archer. 1981.
Simplified monitoring of anatoxin-a by reverse-phase high performance liquid chromatography
and the sub-acute effects of anatoxin-a in rats. In: The Water Environment: Algal Toxins and
Health, W.W. Carmichael, Ed. Plenum Press, New York, NY. p. 437-446. Astrachan, N.B., B.G,
Archer and D.R. Hilbelink. 1980, Evaluation of thesubacutetoxicity and teratogenicity of anatoxin-
a. Toxicon. 18(5-6): 684-688.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Anatoxin-a
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 48 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Prev: UCMR1 Meeting summary; Mag:
CyanoHABs - The Florida Experience
HRL Ratios (HRL/CyanoHABs MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



n
PWSs/Sites/Sa
mples




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



%
PWSs/Sites/Sam
pies with
detects
4



Units
States
States
States
Minimum value of
Detects

Non-cancer: -0.35
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects
~10









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data
ug/L
Cancer:



Notes
Prev: Lake Champlain, NY study; Mag: 2000 Florida study




Cyanobacterial toxin
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Aniline
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 49 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Aniline
2438
62533
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.007



0.007



2.5




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date







1993








Critical Effect



Blood- effects; Spleen-effects



spleen



Blood - pigmented or nucleated red blood cells, Blood -
methemoglobinemia-carboxyhemoglobin, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - other esterases




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.6
0.0057
0.0057
B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1






1987



spleen

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


49
6
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
98 L' L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Provisional value; 104-week chronic study in rat for aniline hydrochloride. CUT,
1982.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; CIIT.1982; Basis LOAEL 7.2 mg/kg-d; rat; UF = 1,000
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 12 week oral study in rats; GISAAA Gigiena i Sanitariya. For
English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 24(7), 44,1 959
Supplemental Data





from IRIS


Vol. 27, Suppl. 7; 1987

EPA, CACART, OEHHA, RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Aniline
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 50 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

1,903
937,263
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

7
20
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





ndustrial chemica ; as solvent; synthesis of explosives, rubber accelerators, isocyanates (HSDB)
Value

44.78
0.9

2.02E-06
36000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades Fast







-------
Bensulide
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 51 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Bensulide
9553
741582
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.005














271
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
Plasma & brain ChE inhibition, decreased body weight
gain














Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



35

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
10 6 Li
HRL Ratio(s)
NC HRL/SWC EEC: 0.224
Notes
Reference Dose; Basis = NOAEL 0.5 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
Volume(issue)/page/year-,C42,1991









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Bensulide
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 52 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
545,406





Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
34





Units
States
States
States



Year
1997











Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 158 ug/L
Ground water chronic: 1 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.224
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







Herbicide (HSDB)
Value




9.15E-09

15
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = Biodegrades Slowly with Acclimation







-------
Benzyl chloride
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 53 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Benzyl chloride
4107
100447
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











26.6




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Cardiac - other changes, Gastrointestinal - necrotic
changes, Related to Chronic Data - death




Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.02
0.17
0.17
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1989




Thyroid

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

62
0.2
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude , „ ,
75 L' L
HRL Ratio(s)
No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JJIND8 JNCI, Journal of the National Cancer Institute.
(Washington, DC) V. 61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year
76,1231,1986; 26 week oral study in rats
Supplemental Data






2B from IARC
Lijinsky, 1986


CACART, EPA, RAIS, OEHHA, IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Benzyl chloride
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 54 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Krasner, etal., 2006

HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler


Amount
Released

259
18,750
n
PWSs/Sites/Sa
mples
12


Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0


Number of
States

3
10
%
PWSs/Sites/Sam
pies with
detects
0


Units
States
States
States
Minimum value of
Detects
Not Detected

Non-cancer:
Amount Range
>50M-100M
>50M-100M
Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year

2004
2004
Maximum
value of
Detects
Not Detected






Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not Detected
90% of
Detects
Not Detected
Units for Mag
data

Notes
Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185.

Cancer:







Chemical intermed ate (NTP)
Value

517.8
2.3

4.11E-04
20
27
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly







-------
Butylated hydroxyanisole
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
  August 2009
Page 55 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Butylated hydroxyanisole
28160
25013165
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.249




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











1959




Critical Effect











Liver - changes in liver weight




Prevalence Magnitude
8 4 NLi
HRL Ratio(s)
NC HRL/NREC NA GW MED: 0.484
CAR HRL/NREC NA GW MED: 146
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; AJEBAK Australian Journal of Experimental Biology and
Medical Science. (Adelaide, S.A., Australia) V.1 -64, 1 924-86. Volume(issue);page/year 37,533,1 959
Supplemental Data



Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification


0.0002


2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1



















Vol. 40, Suppl. 7, 1987
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


0.581
175
Y/N
Y/N

ug/L
ug/L










CACART; OEHHA; IARC

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Butylated hydroxyanisole
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                              EPA-OGWDW
  August 2009
Page 56 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal.,2002
Focazio, etal., 2008
HRL Ratios (HRL/NREC NA GW MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler

85

# Sam pies

Amount
Released



n
PWSs/Sites/Sa
mples



2

#with Detects

Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects



2.4

% Samples with
detects
3
0.61
Number of
States



%
PWSs/Sites/Sam
pies with
detects





Minimum value of
Detects

Units
States
States
States
Minimum value of
Detects


Non-cancer: 0.484
Amount Range
>500K-1M
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Maximum
value of
Detects

Year
1997
2004
2004
Maximum
value of
Detects
0.2
Not detected

0.1

Median value of
Detects
0.2
1.2



90% of
Detects




99% of Detects

Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes






National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes



Median value of
Detects


99% of
Detects


Units for Mag
data
ug/L
ug/L
Cancer: 146



Notes
National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci.
&Technol.,36(6), pp. 1202-1211.
A national reconnaissance for Pharmaceuticals and other organic
wastewater contaminants in the United States ~ II. Untreated drinking
water sources. Focazio, etal., 2008. Sci. Tot. Env., 402(2-3), pp. 201-
216.




Food additive (antoxidant) (HSDB)
Value
38 days
1,390
3.5

1.17E-06

15
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slow with acclimation (PBT)







-------
Captan
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 57 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Captan
5825
133062
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.13


0.13

0.1





19.9




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999




1995










Critical Effect
Decreased pup body weight










Kidney, Ureter, Bladder - other changes in urine
composition, Blood - pigmented or nuceated red blood
cells, Biochemical - Enzyme inhibition, induction, or
change in blood or tissue levels - transaminases




Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0024
0.0035
0.0023

3
mg/L
(mgftg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1







1987






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

910
14.6
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/SWC EEC: 84.3
CAR HRL/SWC EEC: 1.35
Notes
Reference Dose; Basis = NOEL 12.5 mg/kg-d; UF = 100

Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see
HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 38(9), 24,1 973
Supplemental Data











CACART; EPA; OEHHA; RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Captan
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
  August 2009
Page 58 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
3,992,782
15
2,938



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
39
3
6



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 10.8 ug/L
Ground water chronic: 0 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 84.3
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 1.35







Fungicide (NTP)
Value

862.2
2.8

7.01 E-09
5.1

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = Biodegrades Sometimes/Reca citrant. However, hydrolysis half-life s 4.9 hrs - 1 8.8 hrs @ pH 7 and 5, respectively.







-------
Chlorate
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 59 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Chlorate
24376
14866683
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.03









5
1.4




Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date










2005





Critical Effect
Thyroid hypertrophy and mineralization









Bone marrow hyperplasia; thyroid folicular hypertrophy
and mineralization
Blood - pigmented or nucleated red blood cells, Blood -
changes in erythrocyte (RBC) count, Nutritional and Gross
Metabolic - weight loss or decreased weight gain




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



mg/L
(mg/kg-d)"1
(mg/kg-d)"1
Not likely to be carcinogenic at
doses that do not alter thyroid












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



210

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
10 10
HRL Ratio(s)
NC HRL/DBP ICR 90% : 0.656
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data - NTP Abstract for TR-51 7; 2-year rat study for sodium chlorate
Lowest Observed Adverse Effect Level; 1-year oral rat study fopr sodium chlorate; Journal of
Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466)
V.5(4)- 1984- Volume(issue)/page/year
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Chlorate
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
  August 2009
Page 60 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

DBP ICR finished water



# PWSs/Sites
sampled
1,713



#with Detects
1,490



% PWSs/Sites
with detects
86.7



Mean value of
Detects
172



Maximum
value of
Detects
2,234



Median value of
Detects
120



90% of
Detects
320



99% of Detects

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS

HRL Ratios (HRL/DBP ICR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released
7,261,557


n
PWSs/Sites/Sa
mples
116






Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
66






Number of
States
16


%
PWSs/Sites/Sam
pies with
detects
56.9






Units
States
States
States
Median of Detects
110

Non-cancer: 0.656
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year
1997
2004
2004
Maximum of
Detects
747
















Units for Mag
data

ug/L
ug/L
ug/L

Units for Mag
data
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes








National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes
For sodium chlorate


Units for Mag data
ug/L
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.aspx

Cancer:




Agricultural defol ant or desiccant and in the production of CIO 2 (HSDB).
Value





1,000,000

Units
days
L/kg
unitless
cm3/g
atm-m3/mol
mg/L

Degradation
Code







Notes





For sodium chlorate


-------
Chloromethane (Methyl chloride)
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 61 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Chloromethane (Methyl chloride
2605
74873
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value


0.004













Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date


2006













Critical Effect


Mild neurological effects in humans occupationally
exposed to Chloromethane













Cancer Data
EPA Lifetime Cancer Risk, ICT*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.013

D
3
mg/L
(mg/kg-d)-'
(mg/kg-d)"1



1981

2001
1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
28
2.69
Y/N
Y/N
mg/L
ug/L
ug/L


2006


developmental
Teratogen



Prevalence Magnitude , „ ,
87 L' L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 2.15
CAR HRL/NCOD R1 90%: 0.207
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data





CUT, 1981


Vol. 41,Suppl. 7, Vol. 71; 1999

CACART, RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Chloromethane (Methyl chloride)
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                             EPA-OGWDW
  August 2009
Page 62 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NGOD Round 2 finished water
NIRS finished water

20,246
23,478


248
528


1.22
2.25


0.01
0.00073


550
312


1.9
1.4


13
5


120
29

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
Krasneretal., 2006

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
3,959



Amount
Released

1,539
1,733,197
n
PWSs/Sites/Sa
mples
11,984
12
356



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
247
1
8.99



Number of
States

10
26
%
PWSs/Sites/Sam
pies with
detects
2.1
8
0.007



Units
States
States
States
Minimum value of
Detects
0.25


Non-cancer: 2.15
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002



21



Year

2004
2004
Maximum
value of
Detects
46

0.04



0.1



0.58



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
0.7
ND
90% of
Detects
2

Units for Mag
data
ug/L
ug/L

Cancer: 0.207



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx
Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185.





Foaming agent; in organic synthes s (HSDB); naturally-occurring gas
Value
15
14
0.91

8.82E-03
5320
43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = Biodegrades Slowly







-------
Clethodim
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 63 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Clethodim
76719
110429624
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.01




0.01









1,360
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect
Increased liver weights increased liver enzymes and
iver histopathology














Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



70

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
10 6 Li
HRL Ratio(s)
NC HRL/SWC EEC: 9.21
Notes
Reference Dose; Basis = NOEL 1 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


Oral study in rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH
44094) Volume(issue)/page/year -,C272,1991









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Clethodim
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 64 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
670,721





Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
39





Units
States
States
States



Year
1997











Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data:
OPP Estimated Environmental Concentration
Surface water chronic: 7.6 ug/L
Ground water chronic: 0.49 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 9.21
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







Herbicide; pesticide degradate
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Cobalt
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 65 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Cobalt
18870
7440484
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.02
0.01


0.0014








Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date




2004


2000








Critical Effect




Blood-increased hemoglobin, polycythemia;
respiratory-effects on lung function


Heart








Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification




2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1






1991





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


70

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,,, _
4 8 NL'
HRL Ratio(s)
NCHRL/NIRS90%:6.67
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; 'multiple studies as cited in ATSDR, 1992; UF = 30; human study; RIVM; Basis
LOAEL = 0.04 mg/kg-d
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data








Vol. 52; 1991; NB: Evaluated as a group; Cancer classifications were used for screening, but no related
quantitative cancer risk data were identified for potency scoring.

IARC, CACART

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Cobalt
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
  August 2009
Page 66 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water



989



3



0.303



6.4



10.6



9.7



10.5



10.6
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
3,297


Amount
Released

1,272
786,491
# PWSs/Sites
sampled

782


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

23.7


Number of
States

17
38
% PWSs/Sites
with detects

0.007


Units
States
States
States
Minimum value of
Detects

Non-cancer: 6.67
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



684


Year

2004
2004
Maximum
value of
Detects

0.22


3.91


53.2


Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data are for cobaltous chloride: Formerly in medicines; as germicide (HSDB); naturally-occurring
Value





534,200

Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BST






Notes
assumed persistent; All use and env. fate data are for cobaltous chloride; BST = biodegrades sometimes/reca citrant







-------
Cumene hydroperoxide
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 67 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Cumene hydroperoxide
2927
80159
Attribute Scores
Potency Severity
4 9
Prevalence Magnitude
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











32.7



382
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Mortality




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



76.4

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; AIHAAP American Industrial Hygiene Association Journal.
(AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issueXpage/year
19,205,1958; 7 week oral study in rats
Supplemental Data


Oral study in rats









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Cumene hydroperoxide
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 68 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

96
443,772
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
15
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





ndustrial chemical (HSDB)
Value


2.16

4.71 E-08
13,900
25
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades Slowly with Acclimation; PBT







-------
Cylindrospermopsin
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 69 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Cylindrospermopsin
81115
143545908
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value








0.00003







Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg*g-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date








2006







Critical Effect








Increased kidney weight







Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.21

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „
5 10 L'
Scores based on supplemental data HRL Ratio(s)
c^notoxTsuryr00" *"** °" ""** NC HRL/CyanoHABs MAX: -0.0021
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis LOAEL 60 ug/kg-d; NOAEL 3 ug/kg-d. Humpage, A.R. and I.R.
Falconer. 2003. Oral toxicity of the cyanobacterial toxin Cylindrospermopsin in male Swiss albino
mice: Determination of no observed adverse effect level for deriving a drinking water guideline
value. Environ. Toxicol. 18(2):94-103.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Cylindrospermopsin
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 70 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CyanoHABs - The Florida Experience
UCMR 1 Meeting summary

HRL Ratios (HRL/CyanoHABs MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



n
PWSs/Sites/Sa
mples






Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects






Number of
States



%
PWSs/Sites/Sam
pies with
detects
Not Available
Not Available




Units
States
States
States
Minimum value of
Detects



Non-cancer: -0.0021
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects
-100
90










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects



99% of
Detects



Units for Mag
data
ug/L
ug/L

Cancer:



Notes
2000 Florida study
Florida survey






Cyanobacterial toxin
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Dicrotophos
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 71 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dicrotophos
6098
141662
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00007
0.0001

0.0001











11
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1986














Critical Effect
Decreased plasma, RBC & brain ChE activity
Decreased body weight













Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



Suggestive
evidence

mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.49

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 2.45
Notes
Reference Dose; Basis = LOAEL 0.02 mg/kg-d; UF = 300.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa,
Ont, Canada) Volume(issue)/page/year 6,196,1973




OPP; no quantif cation




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Dicrotophos
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
  August 2009
Page 72 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water



Amount
Released
359,726


n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration



Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0



Number of
States
13


%
PWSs/Sites/Sam
pies with
detects
0
0



Units
States
States
States
Minimum value of
Detects





Year



Maximum
value of
Detects
0
0
Surface water chronic: 0.2 ug/L









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects
0
0
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA); 2002
2002
Ground water chronic: 0.005 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 2.45
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







nsecticide (HSDB)
Value

366.2
-0.49

5.05E-11
1,000,000
39
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = Biodegrades Slowly







-------
Dimethipin
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 73 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dimethipin
36818
55290647
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0218
0.02

0.02

0.02










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1986




1999










Critical Effect
Kidney, lungs, duodenum, liver, glandular stomach,
heart, aortic artery & testes toxicity. Decreased body
weight gain.
ncreased absolute and relative liver weight














Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



C

mg/L
(mg/kg-d)"1
(mg/kg-d)-1





1987






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



153

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
8 5 Li
HRL Ratio(s)
NC HRL/GWC EEC: 1.55
Notes
Reference Dose; Basis = NOEL 2.1 8 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Dimethipin
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 74 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
282,458
0
250



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
14
0
1



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 7.3 ug/L
Ground water chronic: 99 ug/L

HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.55
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







Herbicide; plant growth regulator (HSDB)
Value

27.41
-0.17

2.30E-11
4,600
46
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = biodegrades slowly with acclimation; PBT







-------
Dimethoate
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 75 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dimethoate
2413
60515
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0022
0.0002

0.0002

0.002





3




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2007
1988



1996










Critical Effect
Brain cholinesterase inhibition
Brain cholinesterase nhibition









Blood - other changes, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - true
cholinesterase




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



C

mg/L
(mg/kg-d)"1
(mg/kg-d)"1





2006






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

15.4

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude , „ ,
10 7 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 0.655
Notes
Reference Dose; OPP RED
Reference Dose; Basis NOEL 0.05 mg/kg-d; UF = 100. American Cyanamid Co., 1986a
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level - 52-week study in rat; BJIMAG British Journal of Industrial
Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
Volume(issue)/page/year21,52,1964
Supplemental Data







OPP



UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Dimethoate
   CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                           EPA-OGWDW
  August 2009
Page 76 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water

CAL DHS
STORE!




Amount
Released
1,896,947
2,615
31,480
n
PWSs/Sites/Sa
mples


n
PWSs/Sites/Sa
mples
7,238
890
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
4

#with Detects
0
14




Number of
States
44
2
4
%
PWSs/Sites/Sam
pies with
detects
1.3

%
PWSs/Sites/Sam
pies with
detects
0
1.57




Units
States
States
States
Minimum value of
Detects


Minimum value of
Detects

0.055




Year
1997
2004
2004
Maximum
value of
Detects
0.022

Maximum
value of
Detects

0.21
Surface water chronic: 23.5 ug/L
Non-cancer: 0.655
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002















Units for Mag No(es
data

ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes


Median value of
Detects


Median value of
Detects

0.148
95% of
Detects


90% of
Detects

0.198
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx

Ground water chronic: 0.044 ug/L
Cancer:







Pesticide (NTP)
Value
8
5.2-36
0.78

2.43E-10
23,800
36
Units
weeks
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = biodegrades slowly with acclimation







-------
Disulfoton
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 77 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Disulfoton
6423
298044
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00013
0.00004
0.0001
0.00004
0.00006
0.0003





0.06




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2002
1986
2006

08/1995
1991










Critical Effect
Plasma, RBC, brain & corneal ChE inhibition










Brain and Coverings - other degenerative changes, Blood -
other changes, Biochemical - Enzyme inhibition, induction,
or change in blood or tissue levels - true cholinesterase




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification



E

mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.0035
0.91

Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NCHRL/NAWQA90%: 1.1
Notes
Reference Dose; Basis = NOAEL 0.013 mgrtsg-d; UF = 100.
Reference Dose; Basis = LOAEL 0.04 mg/kg-d; UF = 1 ,000.
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press,
Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
Volume(issue)/page/year35,101,1997
Supplemental Data, ITER







Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for
potency scoring.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.

-------
      Disulfoton
      CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                              EPA-OGWDW
  August 2009
Page 78 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300



0



0



Not Detected



Not Detected



Not Detected



Not Detected



Not Detected



Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water

HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118


Amount
Released
1,196,066


n
PWSs/Sites/Sa
mples


17


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
0.24


Number of
States
33


%
PWSs/Sites/Sam
pies with
detects
0
0
0.002


Units
States
States
States
Minimum value of
Detects



Non-cancer: 1.1
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



3.81


Year
1997


Maximum value
of Detects
Not Detected
Not Detected
0.02


0.826


3.81


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of Detects
Not Detected
Not Detected
Units for Mag
data



Cancer:



Notes
Pesticide Pilot Mentoring Program (USGS/EPA); 2002
2002





nsecticide (HSDB)
Value
7-41
684-14,013
4.02

2.20E-06
16.3
17
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
BS = Biodegrades Slowly







-------
Diuron
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 79 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Diuron
6583
330541
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 4
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.003
0.002
0.003
0.002







1.75




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987
2006













Critical Effect
Hemolytic anemia & compensatory hematopotesis
(decreased erythrocyte count, hemoglobin level, etc).










Blood - changes in serum composition (e.g. TP, bilirubin,
cholesterol), Liver - changes in liver weight, Biochemical -
Enzyme inhibition, induction, or change in blood or tissue
evels - transaminases




Cancer Data
EPA Lifetime Cancer Risk, 104
EPA OPP Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0191

Known/Likely

mg/L
(mg/kg-d)-1
(mg/kg-d)-1



2003

2003






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
21
1.83
Y/N
Y/N
mg/L
ug/L
ug/L


2006



Teratogen



Prevalence Magnitude
4 7 NL!
HRL Ratio(s)
NCHRL/UCMR90%: 10
CAR HRL/UCMR 90%: 0.871
Notes
Reference Dose; du Pont, 1364a; Basis = LOAEL 1 .0 mg/kg-d; UF = 300.
Reference Dose; Basis NOEL 0.625 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-day study in rat; TXAPA9 Toxicology and Applied
Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year36,76,1990
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.


EPA, CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Diuron
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                           EPA-OGWDW
  August 2009
Page 80 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
298


1


0.34


2.1


2.1


2.1


2.1


2.1


Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,552



Amount
Released
4,370,448
10
798
n
PWSs/Sites/Sa
mples
270


319



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
117
13
7.00



Number of
States
39
2
5
%
PWSs/Sites/Sam
pies with
detects
0.4
37.5
5.8
0.0004



Units
States
States
States
Minimum value of
Detects
0.058


Non-cancer: 10
Amount Range
>1M-10M

Units
Ibs/yr
Ibs/yr
Year
1998
2002



23.3



Year
1997
2004
2004
Maximum
value of
Detects
0.058
0.54
0.079
0.09



0.915



8.4



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects



95% of
Detects

0.319
0.079
Units
ug/L
ug/L
ug/L
Cancer: 0.871



Notes

Pesticide Data Program (USDA); 2002





Herbicide (HSDB
Value

224-879
2.68

5.8E-10
36.4
15
Units
months
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BST






Notes
BST = biodegrades sometimes/recalcitrant







-------
Equilenin
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 81 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Equilenin
81750
517099
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
9 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormonal response in post-menopausal
women










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.35

Y/N
Y/N
mg/L
ug/L
ug/L










3-model Categorical Prediction
L?-L
HRL Ratio(s)
NC HRL/Kolpin MAX: 1.26
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Equilenin
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 82 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal., 2002

HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released


n
PWSs/Sites/Sa
mples
70






Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects







Number of
States


%
PWSs/Sites/Sam
pies with
detects
2.8






Units
States
States
States
Minimum value of
Detects


Non-cancer: 1.26
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year


Maximum
value of
Detects
0.278
















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
0.14

90% of
Detects


Units for Mag
data
ug/L
Notes
National Surfac
Sci.&Technol
e Water Reconnaissance; Kolpin, etal., 2002. Env.
36(6), pp. 1202-1211.

Cancer:







Pharmaceutical, hormone
Value


3.93


1.52

Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Equilin
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 83 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Equilin
81748
474862
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
8 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormonal response in post-menopausal
women










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.35

Y/N
Y/N
mg/L
ug/L
ug/L










3-model Categorical Prediction
L?-L
HRL Ratio(s)
NC HRL/Kolpin MAX: 2.38
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Equilin
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 84 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, etal., 2002

HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released


n
PWSs/Sites/Sa
mples
ro




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects





Number of
States


%
PWSs/Sites/Sam
pies with
detects
1.4




Units
States
States
States
Minimum value of
Detects


Non-cancer: 2.38
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year


Maximum
value of
Detects
0.147










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
0.147

90% of
Detects


Units for Mag
data
ug/L
Notes
National Surfac
Sci. & Technol
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.

Cancer:







Pharmaceutical, hormone
Value
38

3.35


1.41
13
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slowly with acclimation







-------
Erythromycin
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 85 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Erythromycin
75632
114078
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.0007






66.7



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





2006










Critical Effect





Inhibition of beneficial gastrointestinal bacteria










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

4.9

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
10 4
HRL Ratio(s)
NC HRL/NREC MAX: 2.88
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)











UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Erythromycin
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 86 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Focazio, etal., 2008

HRL Ratios (HRL/NREC MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler

104
90

Amount
Released



n
PWSs/Sites/Sa
mples



22
0

Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects



21.5
0.0

Number of
States



%
PWSs/Sites/Sam
pies with
detects




Not detected

Units
States
States
States
Minimum value of
Detects


Non-cancer: 2.88
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002




1.7
Not detected

Year



Maximum
value of
Detects
0.3


0.1
Not detected



Not detected



Not detected

Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


90% of
Detects


Units for Mag
data
ug/L
Notes
Drinking water monitoring; Focazio, etal., 2008. Sci.Tot. Env. 402(2-3),
pp. 201-216.

Cancer:







Pharmaceutica , antibiotic
Value
180

3.06

5.20E-29

6
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = Biodegrades sometimes/recalcitrant







-------
Estradiol (17-beta estradiol)
CCL 3 Contaminant Information Sheet
                                                                                                EPA-OGWDW
  August 2009
Page 87 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estradiol (17-beta estradiol)
2130
50282
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormona response in post-menopausal women










Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


39

1
mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.35
0.0009
Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude ,
10 5 L
HRL Ratio(s)
NC HRL/Kolpin MAX: 1.75
CAR HRL/Kolpin MAX: 0.0045
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










IARC, CACART, OEHHA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
    Estradiol (17-beta estradiol)
    CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                                EPA-OGWDW
  August 2009
Page 88 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released


n
PWSs/Sites/Sa
mples


85




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects







Number of
States


%
PWSs/Sites/Sam
pies with
detects
0.0

10.6




Units
States
States
States
Minimum value of
Detects
Not detected


Non-cancer: 1.75
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year


Maximum
value of
Detects
Not detected
0.0064
0.2












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
Not detected

0.16
90% of
Detects
Not detected


Units for Mag No(es
data
ug/L
ug/L
ug/L
Cancer: 0.0045



Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
National Surface Water Reconnaissance; Kolpin, et al., 2002. Env.
Sci.&Techno ., 36(6), pp. 1202-1211.




Pharmaceutical, hormone
Value
38

4.01

6.40E-11
3.6
11
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slowly with acclimation







-------
Estriol
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 89 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estriol
75525
50271
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
10 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFAADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormonal response in post-menopausal
women










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

0.35

Y/N
Y/N
mg/L
ug/L
ug/L










3-model Categorical Prediction
L?
HRL Ratio(s)
NC HRL/Kolpin MAX: 6.86
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data











UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Estriol
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
  August 2009
Page 90 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



n
PWSs/Sites/Sa
mples


70



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects






Number of
States



%
PWSs/Sites/Sam
pies with
detects
0.0
0.0
21.4



Units
States
States
States
Minimum value of
Detects
Not detected
Not detected

Non-cancer: 6.86
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects
Not detected
Not detected
0.051









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not detected
Not detected
0.019
90% of
Detects
Not detected
Not detected

Units for Mag
data
ug/L
ug/L
ug/L
Cancer:



Notes
Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
National Surfac
Sci. & Techno .
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.




Pharmaceutica , hormone
Value
38

2.45

1.33E-12
441
17
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slowly with acclimation







-------
Estrone
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 91 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Estrone
2210
53167
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JECFA ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value





0.00005










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect





Estrogenic hormonal response in post-menopausal
women










Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.35

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
9 3 Li
HRL Ratio(s)
NC HRL/Swartz MAX: 2.92
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake for E2
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Estrone
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                           EPA-OGWDW
  August 2009
Page 92 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Boyd, etal.,2003
Snyder, 2008
Kolpin.etal., 2002
Swartz, etal.,2006
HRL Ratios (HRL/Swartz MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released



n
PWSs/Sites/Sa
mples


70





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects








Number of
States



%
PWSs/Sites/Sam
pies with
detects


7.1





Units
States
States
States
Minimum value of
Detects
Not detected



Non-cancer: 2.92
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year



Maximum
value of
Detects
Not detected
0.002
0.112
0.12












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not detected

0.027

90% of
Detects
Not detected



Units for Mag No(es
data
Finished Drinking Water; Boyd, etal, 2003. Sci. Tot. Env. 311(1-3): pp.
135-149.
ug/L
ug/L
ug/L
Cancer:



Raw Drinking Water; Snyder, et al, 2008. Removal of Endocrine
Disrupters and Pharmaceuticals during Water Treatment. In: Fate of
Pharmaceuticals in the Environmental and in Water Treatment Systems.
National Surfac
Sci. & Technol
e Water Reconnaissance; Kolpin, et al., 2002. Env.
36(6), pp. 1202-1211.
Ambient Water (SW/GW); Swartz, et al., 2006. Env. Sci. & Technol.
40(16): pp. 4894-4902.




Pharmaceutical, hormone
Value
38

3.13

3.80E-10
30
13
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades slowly with acclimation







-------
Ethinyl Estradiol
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
  August 2009
Page 93 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethinyl Estradiol (17-alpha ethynyl estradiol)
2327
57636
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.04

0.015
0.0005



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











2001

1981




Critical Effect











Hematalogical effects

Increased serum levels of alanine aminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GGT).




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.28

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
10 4 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.337
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, etal., 1981 as cited in Maier and Hermann, 2001.
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)










CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Ethinyl Estradiol
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 94 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Snyder, etal., 2007
Snyder, etal., 2007
Kolpin, etal., 2002
HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released


n
PWSs/Sites/Sa
mples


70




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects







Number of
States


%
PWSs/Sites/Sam
pies with
detects
0.0
0.0
5.7




Units
States
States
States
Minimum value of
Detects (ug/L)
Not detected
Not detected

Non-cancer: 0.337
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year


Maximum
value of
Detects (ug/L)
Not detected
Not detected
0.273












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects (ug/L)
Not detected
Not detected
0.094
90% of
Detects (ug/L)
Not detected
Not detected

Units for Mag
data
ug/L
ug/L
ug/L
Cancer:



Notes
Finished Drinking Water; Snyder, et al., 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Raw Drinking Water; Snyder, et al., 2007. Removal of EDCs and
Pharmaceuticals in Drinking and Reuse Treatment Processes. American
Water Works Association.
Response to Comment on National Surface Water Reconnaissance
Kolpin et al., 2002: Env. Sci. & Technol., 36(18), pp. 4007-4008.




Pharmaceutical, hormone
Value
60

3.67

7.94E-12
11.3
9
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = Biodegrades sometimes/recalcitrant







-------
Ethoprop
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 95 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethoprop
22682
13194484
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0001




0.0004









33
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1999










Critical Effect
Plasma ChE inhibition, Q1* 0.0281 (mg/kg-day)-1 -
Likely.














Behavioral - changes in motor activity (specific assay),
Behavioral - muscle contraction or spasticity
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.12


0.0281
Likely

mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-dr1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


0.7
1.25
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,,, _
7 3 NL'
HRL Ratio(s)
NC HRL/NAWQA 90%: 7.29
CAR HRL/NAWQA 90%: 13
Notes
Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
Volume(issue)/page/year 1 ,693,2001




OPP RED and Ethoprop pesticide tolerances: 73 FR 53725, Spetember 17, 2008



CACART

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Ethoprop
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
  August 2009
Page 96 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water
HRL Ratios (HRL/NAWQA 90% )
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118




Amount
Released
1,010,807
0
77,786
n
PWSs/Sites/Sa
mples


84




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
1.18




Number of
States
28
0
4
%
PWSs/Sites/Sam
pies with
detects
0
0
0.002




Units
States
States
States
Minimum value of
Detects


Non-cancer: 7.29
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



1.95




Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
0.011




0.096




0.8




Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer: 13



Notes
Pesticide Pilot Mentoring Program (USGS/EPA); 2001
2001




nsecticide (HSDB)
Value
75-133
70-120
3.59

1.70E-07
750

Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
hydrolysis only: BST = biodegrades sometimes/recalcitrant







-------
Ethylene glycol
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
  August 2009
Page 97 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene glycol
4599
107211
Attribute Scores
Potency Severity
3 9
Prevalence Magnitude
10 10
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

2
2
2
0.8


0.05



600




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1987
2006

2007


2000








Critical Effect

Kidney toxicity. Increased mortality, neutrophil count,
kidney hemoglobin & hematocrit, chronic nephritis


ncreased total malformations and incidence of extra rib 14
in developmental study


Kidney



Behavioral - fluid intake, Kidney, Ureter, Bladder - changes
in tubules (including acute renal failure, acute tubular
necrosis), Related to Chronic Data - death




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1987






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y
70
14,000

Y/N
Y/N
mg/L
ug/L
ug/L


2006



Teratogen




3-model Categorical Prediction
L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; DePass et al., 1986a; UF = 100; Rat; Basis NOAEL = 200 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; Gaunt etal., 1974; UF = 1,000; Rat
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 2 year oral study in rate; FCTXAV Food and Cosmetics
Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year3,229,1965
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Ethylene glycol
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
  August 2009
Page 98 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

576,990
10,076,483
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

31
49
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Antifreeze; cancelled pesticide; synthetic chemical used in textile manufacture (NTP)
Value

1
-1.36

6.00E-08
1,000,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
Ethylene Oxide
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
  August 2009
Page 99 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene Oxide
2635
75218
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

1.02
0.31

1
mg/L
(mg/kg-d)-1
(mg/kg-d)-'






1994





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.113
Y/N
Y/N

ug/L
ug/L






Teratogen; Developmental



Prevalence Magnitude
10 8
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data





HEAST




CACART; RAIS; OEHHA; EPA; IARC
UMD; CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Ethylene Oxide
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 100 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

4,761
374,110
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

4
38
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Fumigant (NTP); gas
Value

1.435
-0.3

1.48E-04
1,000,000
43
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BS






Notes
PBT; BS = biodegrades slowly







-------
Ethylene thiourea
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 101 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ethylene thiourea
3836
96457
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0002
0.00008
0.00008
0.00008

0.004





1.34




Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1991
2006


1993










Critical Effect
Thyroid toxicity
ncreased incidence of thyroid hyperplasia









Nutritional and Gross Metabolic - weight loss or decreased
weight gain




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.006
0.06
0.045
B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)"1





1988
2001





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.003
1.4
0.06
Y/N
Y/N
mg/L
W/L
W/L


2006



Teratogen; Developmental



Prevalence Magnitude
4 1 NLi
HRL Ratio(s)
NC HRL/GWC EEC: 6.67
CAR HRL/GWC EEC: 0.286
Notes
Reference Dose
Reference Dose; Basis LOAEL 0.25 mg/kg-d. Graham etal., 1975
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 8-week study in rat; JAFCAU Journal of Agricultural and Food
Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn.,
Washington, DC 20037) V.1- 1953- Volume(issue)/page/vear 21,324,1973
Supplemental Data




OPP
OPP




EPA; RAIS; OEHHA; IARC; CACART
UMD; CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Ethylene thiourea
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 102 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total




Amount
Released

5
299




Units
Ibs/yr
Ibs/yr
Ibsfyr




Number of
States

1
4




Units
States
States
States




Year

2004
2004












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 0.1 ug/L
Ground water chronic: 0.21 ug/L

HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 6.67
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.286







Pesticide (NTP)
Accelerator; industrial intermediate (HSDB)
Value
15
6.5
-0.66

3.40E-07
20,000
48
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly




(at 30 C)


-------
Fenamiphos
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 103 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Fenamiphos
27401
22224926
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0001
0.00025
0.0001
0.00025

0.0008










Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1986
2006


1997










Critical Effect
Plasma ChE inhibition.
Cholinesterase inhibit on














Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



E

mg/L
(mg/kg-d)-1
(mg/kg-d)"1





1988






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.0035
0.7

Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 0.051
Notes
Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100.
Reference Dose; Basis = NOEL 0.025 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring. OPP changed cancer classification from D to E.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Fenamiphos
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                           EPA-OGWDW
   August 2009
Page 104 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water



Amount
Released
726,675


n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0



Number of
States
14


%
PWSs/Sites/Sam
pies with
detects
0
0



Units
States
States
States
Minimum value of
Detects





Year
1997


Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 13.7 ug/L
Non-cancer: 0.051
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Ground water chronic: 0.47 ug/L
Cancer:







nsecticide (HSDB)
Value

225.1
3.23

1.21E-09
329
12
Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BSA






Notes
BSA = biodegrades slowly with acclimation; PBT







-------
Formaldehyde
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 105 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Formaldehyde
2119
50000
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.2
0.2
0.2
0.2






12.5




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1990
2006

1999











Critical Effect

Reduced weight gain, histopathology in rats.
Decreased absolute heart, liver, testes & kidney
weights. Increased relative brain, testes weights.


Gastro.






Liver - other changes, Blood - changes in spleen




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



B1
2A
mg/L
(mg/kg-d)"1
(mg/kg-d)"1





1993
1995





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
7
1,400

Y/N
Y/N
ug/L
ug/L
ug/L


2006



Teratogen



Prevalence Magnitude
10 8
HRL Ratio(s)
NC HRL/DBP ICR MED: 184
Notes
Reference Dose
Reference Dose; Basis = NOAEL 15 mg/kg-d; UF = 100. Til etal., 1989
Reference Dose
Reference Dose
Minimal Risk Level; Basis = NOAEL 15 mg/kg-d; ATSDR MRL-int = 0.3 mg/kg-d (Til etal., 1989).
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VCVGK Vrednie chemichescie veshestva, galogen I kislorod
sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing
substances), Bandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,339,1994
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.


CACART; EPA; IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Formaldehyde
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 106 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

DBP ICR




# PWSs/Sites
sampled
227




#with Detects
126




% PWSs/Sites
with detects
55.5




Minimum value of
Detects
5




Maximum
value of
Detects
30.6




Median value of
Detects
7.6




99% of
Detects
29.7




Units for Mag
data
ug/L
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total

HRL Ratios (HRL/DBP ICR MED)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

326,298
26,992,234



Units
Ibs/yr
Ibs/yr
Ibs/yr



Number of
States

31
46



Units
States
States
States

Non-cancer: 184
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004









Units for Mag
data

ug/L
ug/L
ug/L

Notes





Notes


ug/L
ug/L
ug/L
ug/L
ug/L


National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes




Cancer:







Naturally-occurring fungicide (NTP); Disinfection by-Product; gas
Value

1
0.35

3.38E-07
400,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = Biodegrades Fast with Acclimation







-------
Germanium
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 107 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Germanium
18876
7440564
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.318




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Kidney, Ureter, Bladder - changes in tubules (including
acute renal failure, acute tubular necrosis)




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.744

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
4 10 Li
HRL Ratio(s)
NC HRL/NIRS 90% : 0.003
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JJMDAT Japanese Journal of Medicine. (Nankodo Co.,
Ltd., POBS272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information,
see IEDIEP. Volume(issue)/page;year 30,67,1991. EPA believes the RTECS LOAEL may be
incorrectly cited (should be 3.18 not 0.318). Both values suggest listing germanium.
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Germanium
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 108 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water



989



4



0.40



2B



230



220



220



230
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer: 0.003
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data are for germanium diox de: Phosphors, transistors and diodes; electroplating (HSDB); naturally-occurr ng
Value





4,470

Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BST






Notes
assumed persistent; All use and env. fate data are for germanium dioxide; BST = biodegrades sometimes/reca citrant







-------
Halon 1011 (bromochloromethane)
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 109 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Halon 1011 (bromochloromethane)
2613
74975
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value


0.01













Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect


ncreased liver-to-body weight ratio. Cloudy swelling
and vacuolization of hepatocytes.













Prevalence Magnitude
5 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 7
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data



Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification




D

mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-d)"1




















Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.5
70

Y/N
Y/N
mg/L
ug/L
ug/L


2006









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For care nogens, the concentration at the 1 0 "6 cancer risk was used.

-------
    Halon 1011 (bromochloromethane)
    CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 110 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NGOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

12,881
22,974


65
106


0.5
0.461


0.05
0.0023


210
33.4


1
1


10
6


210
27.9

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
Krasner, etal., 2006
HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1/2, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,238
^Samples


Amount
Released



n
PWSs/Sites/Sa
mples


7
#with Detects


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects


0.165
% Samples with
detects


Number of
States



%
PWSs/Sites/Sam
pies with
detects
0.1
0.0
0.01
Minimum value of
Detects


Units
States
States
States
Minimum value of
Detects

Not detected
Non-cancer: 7
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.45
Maximum
value of
Detects


Year
1997
2004
2004
Maximum
value of
Detects

Not detected
0.2
Median value of
Detects


0.422
90% of
Detects


0.45
99% of Detects


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes



Median value of
Detects
1
Not detected
99% of
Detects

Not detected
Units for Mag
data
ug/L

Cancer:



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx
Krasner, etal., 2006. Env. Sci. &Technol. 40 (23): pp. 7175-7185.




Fire extinguishing fluid; chemical intermediate (HSDB)
Value
15 days
23.7
1.41

0.00146
16,700
40
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
BS = Biodegrades slow (PBT)







-------
HCFC-22
CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 111 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
HCFC-22
2654
75456
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











13.5




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











1983




Critical Effect











Brain and Coverings - other degenerative changes,
Blood - changes in other cell count (unspecified),
Nutritional and Gross Metabolic - weight loss or
decreased weight gain




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification




3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1






1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



31.5

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 10 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26-week study in rat; GISAAA Gigiena i Sanitariya. For
English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-
1936- Volume(issue)/page/year 48(8),69,1983
Supplemental Data








Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   HCFC-22
   CCL 3 Contaminant Information Sheet
                                                                                        EPA-OGWDW
   August 2009
Page 112 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

2,972
7,075,769
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
35
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Refrigerant; low-temperature solvent; fluorocarbon resins, especially tetrafluoroethylene polymers (HSDB); gas
Value
15
35.04
1.08

4.07E-02
2,770
43
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly







-------
Hexane
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 113 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Hexane
4858
110543
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.06







1,429




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date



1989












Critical Effect



Decreased body weight gain







Nutritional and Gross Metabolic - weight loss or decreased
weight gain




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1987






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

420

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
10 10 Li
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; Basis LOAEL = 570 mg/kg-d, UF = 10,000, oral rat study. Health and
Environmental Effects Document for n-Hexane, ECAO-CIN-Q076, Environmental Criteria and
Assessment Office, Final Draft, September 1989.
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; TIHEEC Toxicology and Industrial Health. (Princeton Scientific
Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year 1(3), 67,1985
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Hexane
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 114 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

14,489
39,844,882
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

38
53
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>100M-500M
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Naturally-occurring; solvent (NTP)
Value

149
3.9

1.8
9.5

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = biodegrades fast with acclimation







-------
Hydrazine
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 115 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Hydrazine
6460
302012
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.001
3
3
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1

1999










Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.01
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
9 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










CACART; EPA; IARC; OEHHA; RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Hydrazine
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 116 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

5
165,485
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
16
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range

>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical intermed ate; rocket propellant; oxygen/chlorine scavenger (HSDB)
Value

14.3
-2.07

1.44E-08
1,000,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
Mestranol
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 117 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Mestranol
2581
72333
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL (for ethinyl estradiol)
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.04

0.015
0.00083



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











2001

1981




Critical Effect











Hematalogical effects

Increased serum levels of alanineaminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GOT).




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.28

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
94 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.688
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 .
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)










CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
Mestranol
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 118 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Mestranol
2581
72333
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL (for ethinyl estradiol)
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.04

0.015
0.00083



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











2001

1981




Critical Effect











Hematalogical effects

Increased serum levels of alanineaminotransferase
(ALT), aspartate aminotransferase (AST) and y-
glutamultransferase (GOT).




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.28

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
94 Li
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.688
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 .
Lowest Observed Adverse Effect Level
Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 .
Supplemental Data; Maximum Recommended Da ly Dose (MRDD)










CACART
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Mestranol
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 119 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin.etal., 2002

HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released


n
PWSs/Sites/Sa
mples
70





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects






Number of
States


%
PWSs/Sites/Sam
pies with
detects
4.3





Units
States
States
States
Minimum value of
Detects


Non-cancer: 0.688
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year


Maximum
value of
Detects
0.407













Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
0.017

90% of
Detects


Units for Mag
data
ug/L
Notes
Response to Comment on National Surface Water Reconnaissance
Kolpin et al., 2002: Env. Sci. & Technol, 36(18), pp. 4007-4008.

Cancer:







Metabolite of ethinyl estradiol
Value
60

4.68


Practically
insoluble
9
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = Biodegrades sometimes/recalcitrant







-------
   Methamidophos
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 120 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
965,584





Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
39





Units
States
States
States



Year
1997











Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 6.9 ug/L
Ground water chronic: 3.8 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.304
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







nsecticide (HSDB)
Value

3.848
-0.8

8.70E-10
1000000
39
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = Biodegrades Slowly







-------
Methanol
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 121 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Methanol
2508
67561
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.5

0.5







3.13



5,600
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1988














Critical Effect

ncreased SAP & SGPT& liver weight, decreased brain
weight









Liver - other changes



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

3,500

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude , „ ,
10 10 L' L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose; U.S. EPA, 1986; Basis = NOEL 500 mg(kg-d; UF = 1,000; Rat
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 200 day oral study in rats; VCVGK "Vrednie chemichescie
veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen
and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year -
,89,1994
Supplemental Data


Rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie
soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al.,
Chimia, 1994. Volume(issue)/page/year -,87,1984








UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Methanol
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 122 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

10,966,234
201,697,278
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

41
52
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





ndustrial solvent; gasoline additive (HSDB); anti-freeze
Value

1
-0.77

4.56E-06
1000000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades Fast







-------
Methyl bromide (Bromomethane)
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 123 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Methyl bromide (Bromomethane
2601
74839
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.0014
0.001
0.0014
0.003
1





29.9




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1988
2006

9/1992
1966










Critical Effect

Epithelial hyperplasia in theforestomach


Gastro






Kidney, Ureter, Bladder - other changes in urine
composition, Skin and Appendages - hair, Nutritional and
Gross Metabolic - we ght loss or decreased weight gain




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D
3
mg/L
(mg/kg-d)"1
(mg/kg-d)"1





1989
1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y
0.05
9.8

Y/N
Y/N
mg/L
ug/L
ug/L


2006



Developmental



Prevalence Magnitude , „
67 L
HRL Ratio(s)
NC HRL/NCOD R1 90%: 0.891
Notes
Reference Dose
Reference Dose; Basis = NOAEL 1 .4 mg/kg-day; UF = 1 ,000; Rat. Danse et al.r 1984
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 2-year oral study in rat; FCTOD7 Food and Chemical Toxicology.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
Volume(issue)/page/year28,109,1990
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Methyl bromide (Bromomethane)
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 124 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

20,198
23,328


155
175


0.77
0.75


0.07
0.09


43
38.1


1
1.6


11
8.1


34
27.2

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,317



Amount
Released
32,803,943
200
533,748
# PWSs/Sites
sampled

3



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

0.069



Number of
States
29
3
17
% PWSs/Sites
with detects

0.04



Units
States
States
States
Minimum value of
Detects

Non-cancer: 0.891
Amount Range
>10M-50M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.5



Year
1997
2004
2004
Maximum
value of
Detects

0.1



0.5



0.5



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Cancelled fumigant (NTP); gas
Value
20-26.7
9-22
1.19

7.34E-03
13,400
42
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BS






Notes
hydrolysis only; BS = biodegrades slowly







-------
Methyl tert-butyl ether
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 125 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Methyl tert-butyl ether
11918
1634044
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value




0.3


0.01



300




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date




8/1996


1991








Critical Effect




Hepatic: Decreased blood urea nitrogen levels.






Kidney, Ureter, Bladder - changes in bladder weight, Blood
- changes in serum composition (e.g. TP, bilirubin,
cholesterol), Nutritional and Gross Metabolic - changes in
calcium




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


0.0018

3
mg/L
(mg/kg-d)"1
(mg/kg-d)-1






1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


2,100
19.4
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „
58 L'
HRL Ratio(s)
NC HRL/UCMR 90%: 58.3
CAR HRL/UCMR 90%: 0.539
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake; Basis NOAEL 100 mg/kg-d
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in rat; JACTDZ Journal of the American College of
Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued. Volume(issue)/page/year 9(5), 525, 1990
Supplemental Data










OEHHA

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Methyl tert-butyl ether
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 126 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,617



17



0.47



5



49



9.2



36



49



Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,328


Amount
Released

40,177
2,040,906
# PWSs/Sites
sampled

424


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

9.8


Number of
States

17
42
% PWSs/Sites
with detects

0.01


Units
States
States
States
Minimum value of
Detects

Non-cancer: 58.3
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002



2,300


Year

2004
2004
Maximum
value of
Detects

0.3


7.85


1,800


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer: 0.539



Notes





Octane booster in gasoline; manufacture of isobutene; extraction solvent (HSDB)
Value
15
6
0.94

5.87E-04
51,000
46
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly







-------
Metolachlor
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 127 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor
35270
51218452
Attribute Scores
Potency Severity
4 3
Prevalence Magnitude
6 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.1
0.15
0.1
0.15







25



1,150
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1995
1988
2006













Critical Effect
Decreased body weight gain
Decreased body weight gain









Behavioral - food intake (animal), Nutrtional and Gross
Metabolic - weight loss or decreased weight gain,
Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - phosphatases



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



C

mg/L
(mg/kg-d)"1
(mg/kg-d)-1





1988






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


3.5
700

Y/N
Y/N
mg/L
ug/L
ug/L


2006








3-model Categorical Prediction
NL?
HRL Ratio(s)
NC HRL/NCOD R2 90%: 321
Notes
Reference Dose; Basis NOAEL = 9.7 mg/kg-d; UF = 100. OPP RED.
Reference Dose; Basis = NOEL 15 mg/kg-d; UF = 100. Ciba-Geigy, 1983
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989
Supplemental Data


NNGADV Nippon Noyaku Gakka shi. Journal of the Pesticide Science Society of Japan. (Nippon
Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
Volume(issue)/page/year 14,103,1989




Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 ~6 cancer risk was used.

-------
   Metolachlor
   CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                            EPA-OGWDW
   August 2009
Page 128 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


13,007



116



0.89



0.01



13.8



0.57



2.18



7.1

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
PPMP ambient water
PPMP finished water

CAL DHS
STORE!
HRL Ratios (HRL/NCOD R2 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,165



Amount
Released
67,336,211


n
PWSs/Sites/Sa
mples
203
582


n
PWSs/Sites/Sa
mples
7,345
2,082
1,817



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
102
233
288
198
#with Detects
15
676
25.4
8.76
1.23

Number of
States
48


%
PWSs/Sites/Sam
pies with
detects
50.2
40
89.2
86.8
%
PWSs/Sites/Sam
pies with
detects
0.2
32.5
0.0002



Units
States
States
States
Minimum value of
Detects
0.01
0.005


Minimum value of
Detects
0.05
0.00867
Non-cancer: 321
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



77.6



Year
1997


Maximum
value of
Detects
0.079
0.226
3.32
0.661
Maximum
value of
Detects
0.7
86
0.025
0.12
0.125

0.58



6.71



Units for Mag No(es
data

ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes



Median value of
Detects




Median value of
Detects
0.06
0.19
95% of
Detects


0.033
0.336
90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Pesticide Data Program (USDA); 2001
2002
Pesticide Pilot Mentoring Program (USGS/EPA)

Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





Herbicide (HSDB)
Value
47;78
22-310
3.13

9.00E-09
530
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
aerobic;anaerobic; BSA = biodegrades slow with acclimaton







-------
Metolachlor ESA
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 129 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor ethanesulfonic acid (ESA)
79218
171118095
Attribute Scores
Potency Severity
2 1
Prevalence Magnitude
6 6
Scores based on parent
HEALTH EFFECTS DATA1 - See Metolachlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










21000





Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










No biologically significant effects





Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)"1












Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



>7,000

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : >3,210 (NAWQA data for metolachlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR ESA
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.

-------
     Metolachlor ESA
     CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                            EPA-OGWDW
   August 2009
Page 130 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value
of Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag No(es
data
Finished Water Occurrence Data - FOR METOLACHLOR PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


13,007



116



0.89



0.01



13.8



0.57



2.18



7.1

Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
FOR METOLACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NCOD R290%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



n
PWSs/Sites/Sa
mples
83
318
n
PWSs/Sites/Sa
mples
7,345
2,082



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
19
198
#with Detects
15
676



Number of States



%
PWSs/Sites/Samp
les with detects
22.9
51.9
%
PWSs/Sites/Samp
les with detects
0.2
32.5



Units
States
States
States
Minimum value
of Detects
0.50
0.02
Minimum value
of Detects
0.05
0.00867
Non-cancer: >3,210
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects
2.21
2.24
Maximum
value of
Detects
0.7
86









ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes



Median value of
Detects


Median value of
Detects
0.06
0.19
95% of
Detects


90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR ESA
2002 - FOR METOLACHLOR ESA
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.as
px

NCOD data for metolachlor - parent



Pesticide degradate
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation Code







Notes








-------
Metolachlor OA
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 131 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Metolachlor oxani ic acid (OA)
79220
152019733
Attribute Scores
Potency Severity
2 1
Prevalence Magnitude
6 6
Scores based on parent
HEALTH EFFECTS DATA1 - See Metolachlor Parent
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










1,000





Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










No biologically significant effects





Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



7,000

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
NL
HRL Ratio(s)
HRL/NAWQA 90% : 3,210 (NAWQA data for metolachlor
parent)
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR OA
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used.

-------
     Metolachlor OA
     CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                            EPA-OGWDW
   August 2009
Page 132 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Units for Mag No(es
data
Finished Water Occurrence Data - FOR METOLACHLOR PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


13,007



116



0.89



0.01



13.8



0.57



2.18



7.1

Ambient Water Occurrence Data
N AWQA ambient water
MREC ambient surface water
MREC ambient ground water
MREC ambient surface water
MREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
FRI Release - surface water
TRI Release - total
Supplemental Water Data
POP finished water
POP finished water
FOR METOLACHLOR - PARENT
CAL DHS
STORE!
HRL Ratios (HRL/NCOD R290%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KQC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released


n
PWSs/Sites/Sa
mples
138
404
n
PWSs/Sites/Sa
mples
7,345
2,082




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
14
152
#with Detects
15
676




Number of
States


%
PWSs/Sites/Sam
pies with
detects
10.1
37.6
%
PWSs/Sites/Sam
pies with
detects
0.2
32.47




Units
States
States
States
Minimum value of
Detects
0.50
0.02
Minimum value of
Detects
0.05
0.00867
Non-cancer: 3,210
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year


Maximum
value of
Detects
4.42
1.41
Maximum
value of
Detects
0.7
86












ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes


Median value of
Detects


Median value of
Detects
0.06
0.19
95% of
Detects


90% of
Detects
0.1
1.4
Units for Mag
data
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR OA
2002 - FOR METOLACHLOR OA
Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.
aspx

NCOD data for metolachlor - parent



Pesticide degradate
Value







Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Microcystin-LR
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 133 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Microcystin-LR
76859
101043372
Attribute Scores 3-model Categorical Prediction
Potency Severity
9 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value








0.000003







Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date








2006







Critical Effect








Liver effects







Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.021

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
10 4
Scores based on supplemental data HRL Ratio(s)
NC HRL/AWWARF Typical Range MAX: 0.21
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data - draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y., Y. Makita, S. Nagata et al. 1 999.
No chronic oral toxicity of a low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female
Balb/C mice. Environ. Toxicol. 14(1):45-55.
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
    Microcystin-LR
    CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                             EPA-OGWDW
   August 2009
Page 134 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
US and Canadian drinking water (bloom
area, source, finished water)
US and Canadian drinking water (bloom
area, source, finished water)
HRL Ratios (HRL/AWWARF Typical Range
MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released



n
PWSs/Sites/Sa
mples
677
677





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
542
542





Number of
States



%
PWSs/Sites/Sam
pies with
detects
80
80





Units
States
States
States
Minimum value of
Detects

0.002
Non-cancer: 0.21
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year



Maximum
value of
Detects
0.1
1,200















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


99% of
Detects


Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Maximum of typical range of detects (AWWARF, Carmichael)
Maximum and m numum of detects (AWWARF, Carmichael)




Cyanobacterial toxin
Value







Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Molinate
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 135 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Molinate
12912
2212671
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001
0.002

0.002







13.1




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2001
1988














Critical Effect
Degeneration/demyelination in sciatic nerve and
atrophy/reserve cell hyperplasia of muscle
Reproductive toxicity. Alteration in sperm morphology,
reduced number of viable fetuses/litter, increased
number of resorptions/litter









Endocrine - other changes, Blood - normocytic anemia,
Nutritional and Gross Metabolic - body temperature
decrease




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



14

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „
1 8 L'
HRL Ratio(s)
NCHRL/UCMR90%: 2.46
Notes
Reference Dose; Basis LOAEL = 0.3 mg/kg-d, UF = 300, 2-year rat study. A Determination of the
Existence of a Common Mechanism of Toxicity and a Screening Level Cumulative Food Risk
Assessment, December 2001. OPP issued RfD as part of health assessment not the RED;
http://epa.gov/oppsrrd1/cumulative/thiocarb.pdf
Reference Dose; Basis NOEL 0.2 mg/kg-d; UF = 100. Stauffer Chemical Co., 1981
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 43 week study in rat; GISAAA Gigiena i Sanitariya. For English
translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 40(1 0) , 1 04, 1 975
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Molinate
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 136 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,621


1


0.03


5.7


5.7


5.7


5.7


5.7


Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water

HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118



Amount
Released
3,669,398
115
2,089
n
PWSs/Sites/Sa
mples

120



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
1
1.68



Number of
States
6
1
2
%
PWSs/Sites/Sam
pies with
detects
0.3
0.001



Units
States
States
States
Minimum value of
Detects


Non-cancer: 2.46
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



200



Year
1997
2004
2004
Maximum
value of
Detects
0.004
0.0372



3.41



47.9



Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects

95% of
Detects

Units
ug/L

Cancer:



Notes
Pesticide Pilot Mentoring Program (USGS/EPA)





Herbicide (HSDB)
Value
40-160
80-120
3.21

4.10E-06
970
19
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BST






Notes
BST = biodegrades sometimes/recalcitrant







-------
Molybdenum
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 137 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Molybdenum
18825
7439987
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.005
0.005
0.005




0.03


0.5




Units
mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1992
2006













Critical Effect

increased uric acid levels






Effects on repro & fetal development (decreased
gestational weight ga n, prolonged estrus cycle, failure to
breed). Renal failure, diuresis, proteinuria


Liver - other changes, Kidney, Ureter, Bladder - other
changes, Nutritional and Gross Metabolic - weight loss or
decreased weight ga n




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)-1
(mg/kg-d)"1





1993






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y
0.2
35

Y/N
Y/N
mg/L
ug/L
ug/L


2006



Teratogen List



Prevalence Magnitude
98 Li
HRL Ratio(s)
NCHRL/NIRS90%: 1.17
Notes
Reference Dose
Reference Dose; Koval'skiy et al.( 1961; oral study in humans; UF = 30; Basis LOAEL = 0.14 mg/kd-
d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; UL; IOM
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1 9 week oral study in rabbits; VCVN5 "Vrednie chemichescie
veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic
substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
Volume(issue)/page/year -, 317, 1989
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.



UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Molybdenum
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 138 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


989


77


7.79


6.1


180


10


30


110
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler


Amount
Released


# PWSs/Sites
sampled



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects



Number of
States


% PWSs/Sites
with detects



Units
States
States
States
Minimum value of
Detects

Non-cancer: 1.17
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year


Maximum
value of
Detects







Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data for molybdenum trioxide: As steel alloy; chemical reagent (HSDB); naturally-occurring
Value





1,066

Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BST






Notes
assumed persistent; All use and env. fate data for molybdenum trioxide; BST = biodegrades sometimes/reca citrant




All use and env. fate data for molybdenum trioxide


-------
Nitrobenzene
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 139 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Nitrobenzene
3998
98953
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.002

0.0005












Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

2009














Critical Effect

Increased reticulocytesand methemaglobinemia














Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1990
1996





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

14

Y/N
Y/N

ug/L
ug/L






Teratogen List



Prevalence Magnitude
1 10 NLi
HRL Ratio(s)
NCHRL/UCMRAM90%: 0.14
Notes
Reference Dose
Reference Dose; NTP, 1983; subchronic rat study; UF = 1,000; Basis BMDL = 1.8 mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.


CACART, IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Nitrobenzene
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 140 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,064


2


0.065


21. 6


100


60.8


100


100


Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
UCMR finished water

HRL Ratios (HRL/UCMR AM 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released

60
350,301
# PWSs/Sites
sampled
338





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0





Number of
States

1
14
% PWSs/Sites
with detects
0





Units
States
States
States
Minimum value of
Detects
Not Detected

Non-cancer: 0.14
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year

2004
2004
Maximum
value of
Detects
Not Detected















Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes

Analyzed under UCMR 1 , List 1 , Assessment
Monitoring with detection limit of 10 ug/L.





National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not Detected
99% of
Detects
Not Detected
Units for Mag
data
Not Detected

Cancer:



Notes
Analyzed under UCMR 1, List 2, Screening Survey with detection limit of
0.5 ug/L.





Solvent (NTP)
Value
15
30.6-370
1.85

2.40E-05
1,800
31
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
BS = biodegrades slowly







-------
Nitroglycerin
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
   August 2009
Page 141 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Nitroglycerin
2252
55630
Attribute Scores
Potency Severity
7 6
Prevalence Magnitude
7 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











0.125
0.008


105
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Cardiac - cardiomyopathy including infarction, Cardiac
- EKG changes not diagnostic of specified effects,
Biochemical - Enzyme inhibition, induction, or change
in blood or tissue levels - multiple enzyme effects



Behavioral - somnolence (general depressed activity)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.2




mg/L
(mg/kg-d)-1
(mg/kg-d)-1


1987









Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.292
2
Y/N
Y/N

ug/L
ug/L






Teratogen




3-model Categorical Prediction
L?-L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 26 week oral study in rats; FATOAO Farmakologiya i
Toksikologiya (Moscow), For English translation, see PHTXA6 and RPTOAN. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year
48,76,1985
Supplemental Data; RTECS LOAEL, acute human study


Oral study in rats; YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan
K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year 13,3649,1985







EPA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Nitroglycerin
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 142 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released

0.2
55,979
# PWSs/Sites
sampled





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects





Number of
States

1
9
% PWSs/Sites
with detects





Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1M-10M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year

2004
2004
Maximum
value of
Detects













Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Pharmaceutical/medication; production of explosives; Rocket propellants; (HSDB)
Value


1.62

9.87E-08
1,380
32
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades Fast







-------
N-Methyl-2-pyrrolidone
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 143 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Methyl-2-pyrrolidone
9980
872504
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value








0.6


120



3,914
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date








2001







Critical Effect








Decreased weight gain, neurobehavioral effects,
sedative effects


Endocrine - changes in spleen weight



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

4,200

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
10 10 Li
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Tolerable Daily Intake; Basis NOAEL = 169 mg/kg-d, UF = 300, 90-day rat study, WHO/UNEP CICAD
TDI Study #35
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA
22161) Formerly U.S. Clearinghouse for Scientif c & Technical Information. Volume(issue)/page/year
OTS0528073
Supplemental Data


ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(ssue)/page/year 26,1581,1976








UMD; CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   N-Methyl-2-pyrrolidone
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 144 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

17,972
6,311,503
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

13
42
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>100M-500M
>100M-500M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical industry solvent; solvent for pesticide appl cation for food packing materials (HSDB)
Value


-0.38

3.20E-09
1,000,000
42
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = Biodegrades Fast







-------
N-Nitrosodiethylamine (NDEA)
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 145 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodiethylamine (NDEA)
2243
55185
Attribute Scores 3-model Categorical Prediction
Potency Severity
9 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.00002
150
36
B2
2A
mg/L
(mg/kg-d)-1
(mg/kg-d)"1






1987





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.0002
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
1 2 Li
HRL Ratio(s)
See also supplemental water data No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data










CACART; EPA; OEHHA; IARC; RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   N-Nitrosodiethylamine (NDEA)
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 146 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler


Amount
Released

0
1,000
n
PWSs/Sites/Sa
mples
26
26


Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0
0


Number of
States

0
1
%
PWSs/Sites/Sam
pies with
detects
0
0


Units
States
States
States
Minimum value of
Detects
Not Detected
Not Detected
Non-cancer:
Amount Range


Gasoline and lubr
Value
38
142.7
0.48

3.63E-06
106,000
53
Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year

2004
2004
Maximum
value of
Detects
Not Detected
Not Detected






Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not Detected
Not Detected
90% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer:



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





cant additive; antioxidant; stabilizer n plastics (HSDB); Disinfection by-Product
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS/BSA






Notes
BS = Biodegrades Slowly; BSA = Biodegrades Slowly with Acclimation







-------
N-Nitrosodimethylamine (NDMA)
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 147 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodimethylamine (NDMA)
2446
62759
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.000008







0.2




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











mmunological Includ ng Allergic - decrease in cellular
immune response, Immunological Including Allergic -
decrease in humoral mmune response, Related to Chronic
Data - death




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.00007
51
16
B2
2A
mg/L
(mg/kg-d)"1
(mg/kg-d)"1





1986
1987



Liver

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.056
0.00069
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude , „ ,
10 2 L' L
Scores based on supplemental data HRL Ratio(s)
NC HRL/CAL DHS 90%: 0.329
CAR HRL/CAL DHS 90%: 0.004
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; JTEHD6 Journal of Toxicology and Environmental Health.
(Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year 37,351 ,1992
Supplemental Data




IRIS



(Vol. 17, Suppl. 7; 1987)

CACART; RAIS; EPA; OEHHA; IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   N-Nitrosodimethylamine (NDMA)
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 148 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released



n
PWSs/Sites/Sa
mples
409
585




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
87
0




Number of
States



%
PWSs/Sites/Sam
pies with
detects
21.3
0




Units
States
States
States
Minimum value of
Detects
0.001
Not Detected
Non-cancer: 0.329
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year



Maximum
value of
Detects
440
Not Detected












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
0.009
Not Detected
90% of
Detects
0.17
Not Detected
Units for Mag
data
ug/L
ug/L
Cancer: 0.004



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwaterfPages/Chemicalconta
minants.aspx





ndustrial solvent; antioxidant; formerly in the production of rocket fuel (HSDB); Disinfection by-Product
Value
38
12
-0.57

1.82E-06
Soluble
52
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = Biodegrades Slowly with Acclimation



@37°C



-------
N-Nitroso-di-n-propylamine NDPA
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 149 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitroso-di-n-propylamine (NDPA)
8798
621647
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.0005
7
7
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1





1987
1987



Liver

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y


0.005
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude .,, „
2 2 NL.-L,
HRL Ratio(s)
See also supplemental water data CAR HRL/STORET 90% : 0.00049
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data




IRIS





CACART; EPA; RAIS; OEHHA; IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   N-Nitroso-di-n-propylamine NDPA
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 150 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS
STORE!
HRL Ratios (HRL/STORET 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

0
506
n
PWSs/Sites/Sa
mples
127
1,309



Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
0
22



Number of
States

0
2
%
PWSs/Sites/Sam
pies with
detects
0
1.68



Units
States
States
States
Minimum value of
Detects
Not Detected
0.19
Non-cancer:
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects
Not Detected
20









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
Not Detected
10
90% of
Detects
Not Detected
10.24
Units
ug/L
ug/L
Cancer: 0.00049



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





Research chemical (HSDB); Disinfection by-Product?
Value
38
130
1.36

5.38E-06
10,000
44
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades Slowly with Acclimation



@37°C



-------
N-Nitrosodiphenylamine
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 151 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
N-Nitrosodiphenylamine
3193
86306
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.02







20.5




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date











1966




Critical Effect



Corneal opacities, epithelial hyperplasia of the bladder
and decreased weight gain







Nutritional and Gross Metabolic - weight loss or decreased
weight gain




Prevalence Magnitude ,,,
2 1 NL
HRL Ratio(s)
NC HRL/CAL DHS 90% : 1 .84
See also supplemental water data CAR HRL/CA|_ DH£. g()% . Q Og32
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; NC1 1979; Basis LOAEL, rat, UF=3000
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 17-week oral study in rabbit; GTPZAB Gigiena Truda i
Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya
Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/paae/vear 10(4). 60.1 966
Supplemental Data



Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Slope Factor
EPA Carcinogen classification
ARC Carcinogen Classification

0.0049
0.009

B2
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
(mg/kg-d)-1







1987







IRIS


Cited by OEHHA
Vol. 27, Suppl. 7
Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


140
7.1
Y/N
Y/N

ug/L
ug/L










CACART; EPA; OEHHA; RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   N-Nitrosodiphenylamine
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                             EPA-OGWDW
   August 2009
Page 152 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
CAL DHS

HRL Ratios (HRL/CAL DHS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



# Sam pies

Amount
Released

0
14
n
PWSs/Sites/Sa
mples
133



#with Detects

Units
Ibs/yr
Ibs/yr
Ibsfyr
#with Detects
1



% Samples with
detects

Number of
States

0
2
%
PWSs/Sites/Sam
pies with
detects
0.75



Minimum value of
Detects

Units
States
States
States
Minimum value of
Detects
76.2

Non-cancer: 1.84
Amount Range

10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Maximum
value of
Detects

Year
1997
2004
2004
Maximum
value of
Detects
76.2



Median value of
Detects




90% of
Detects




99% of Detects

Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Notes






National Reconnaissance
National Reconnaissance
Notes
National Aggregate
National Aggregate
Notes



Median value of
Detects
76.2
90% of
Detects
76.2
Units for Mag
data
ug/L

Cancer: 0.0932



Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





Rubber and polymer additive; chemical reagent (HSDB); DBP
Value

6,154
3.13

1.21E-06
35

Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = Biodegrades fast with acclimaton (BIODEG)







-------
N-Nitrosopyrrolidine (NPYR)
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 153 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
N-Nitrosopyrrolidine (NPYR)
10160
930552
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude

HEALTH EFFECTS DATA1 See also supplemental water data
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.002
2.1
2.1
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1986
1987



Liver

Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y



0.02
Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction

HRL Ratio(s)
No data for calculating HRL ratio
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data




IRIS





CACART; EPA; OEHHA; RAIS; IARC

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   N-Nitrosopyrrolidine (NPYR)
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 154 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
STORE!

HRL Ratios (No data for calculating HRL
ratio)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler





Amount
Released


n
PWSs/Sites/Sa
mples
27





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0





Number of
States


%
PWSs/Sites/Sam
pies with
detects
0





Units
States
States
States
Minimum value of
Detects
Not Detected

Non-cancer:
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002








Year


Maximum
value of
Detects
Not Detected















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
Not Detected
90% of
Detects
Not Detected
Units
ug/L
Notes


Cancer:







Research chemical (HSDB)
Value
38
19
-0.19

4.89E-08
1,000,000
48
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = Biodegrades Slowly with Acclimation



@37°C



-------
Norethindrone (19-Norethisteron
CCL 3 Contaminant Information Sheet
                                                                                              EPA-OGWDW
   August 2009
Page 155 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Norethindrone (19-Norethisterone)
2525
68224
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value













0.0167



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

















Critical Effect













The norethindrone abel indicates that if the drug is
taken during the first trimester of pregnancy that the
riskfor hypospadia in male offspring doubles.



Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
NTP Carcinogen Classification




Reasonably antic
carcinogenic
mg/L
(mg/kg-d)-1
(mg/kg-d)-1

Dated to be










Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

0.04

Y/N
Y/N
mg/L
ug/L
ug/L










Prevalence Magnitude
10 4
HRL Ratio(s)
NC HRL/Kolpin MAX: 0.0459
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data; Maximum Recommended Daily Dose (MRDD)








NTP 1 1th Report on Carcinogens; no quantificatio of dose-response

CACART
UMD, CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Norethindrone (19-Norethisteron
   CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 156 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Kolpin, et al., 2002

HRL Ratios (HRL/Kolpin MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler


Amount
Released


n
PWSs/Sites/Sa
mples
70



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States


%
PWSs/Sites/Sam
pies with
detects
12.8



Units
States
States
States
Minimum value of
Detects


Non-cancer: 0.0459
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002





Year


Maximum
value of
Detects
0.872







Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects
0.048

90% of
Detects


Units for Mag
data
ug/L
Notes
National Surface Water Reconnaissance; Kolpin, etal., 2002. Env.
Sci.&Technol., 36(6), pp. 1202-1211.

Cancer:








Value
60

2.97

5.80E-10
7.04
12
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = Biodegrades sometimes/recalcitrant







-------
n-Propylbenzene
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 157 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
n-Propylbenzene
4328
103651
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











2.5



6,040
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Blood - changes in spleen



Behavioral - somnolence (general depressed activity)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



5.83

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
4 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 1.21
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VCVQH "Vrednie chemichescie veshestva,
galogenproisvodnie uglevodorodov". (Hazardous substances Qalogenated hydrocarbons)
Bandman A.L. et al., Chimia, 1990. Volume(issue)/page/year -,167,1990; 24 week oral study in rat
Supplemental Data


Rats; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher
information, see FCTOD7. Volume(issue)/page/year 2,327,1964









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   n-Propylbenzene
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 158 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

12,724
22,970


42
54


0.33
0.24


0.03
0.1


34
21


0.7
0.6


4.8
4


34
21

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309


Amount
Released



# PWSs/Sites
sampled

53


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

1.23


Number of
States



% PWSs/Sites
with detects

0.004


Units
States
States
States
Minimum value of
Detects

Non-cancer: 1.21
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002



47


Year



Maximum
value of
Detects

0.024


5


47


Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Manufacture of methylstyrene; text le dyeing; printing solvent; asphalt and naphtha constituent (HSDB)
Value
15
495-955
3.69

1.05E-02
23.4
22
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly







-------
o-Toluidine
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 159 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
o-Toluidine
3768
95534
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











340




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Kidney, Ureter, Bladder - proteinuria, Blood - normocytic
anemia, Nutritional and Gross Metabol c - weight loss or
decreased weight ga n.




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.24
0.18

2A
mg/L
(mg/kg-d)-1
(mg/kg-d)-1

2000










Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

793
0.194
Y/N
Y/N

ug/L
ug/L






Teratogen list



Prevalence Magnitude , „ ,
7 5 Li L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; VINIT Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii
(VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information
broker to obtain publications. Vo ume(issue)/page
Supplemental Data





HEAST


Vol. 77; 2000

IARC, RAIS, OEHHA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   o-Toluidine
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 160 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

5
10,774
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
9
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>50M-100M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Intermediate in the manufacture of dyes, rubber, Pharmaceuticals and pesticides (HSDB)
Value

74.04
1.32

1.98E-06
16,600

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
Oxirane, methyl-
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 161 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxirane, methyl-
2661
75569
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001










26




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1981















Critical Effect
ncreased combined incidence of hyperkeratosis,
hyperplasia and papillomas.










Brain and Coverings - other degeneratve changes, Liver -
other changes, Blood - other changes




Cancer Data
EPA Lifetime Cancer Risk, 10"*
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.15
0.24
0.24
B2
2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1
1990






1994






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

60.7
0.233
Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
10 8
HRL Ratio(s)
No water data
Notes
Reference Dose; Basis = BMDL „ 1 .4 mg/kg-d; UF = 1 000.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 45-day study in rat; GISAAA Gigiena i Sanitariya. For English
translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year 46(7), 76,1 981
Supplemental Data











CACART; RAIS; OEHHA; EPA; IARC
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Oxirane, methyl-
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 162 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

28,761
433,536
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

5
28
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>1B
>1B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical intermed ate (NTP)
Value

2.324
0.03

6.98E-05
590,000
44
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BS






Notes
PBT; BS = biodegrades slow







-------
Oxydemeton-methyl
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 163 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxydemeton-methyl
6458
301122
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00013




0.0025









10
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1967










Critical Effect
Decreased erythrocyte & brain ChE




Decreased body weight









Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

0.91

Y/N
Y/N

ug/L
ug/L






male, female



Prevalence Magnitude
95 Li
HRL Ratio(s)
NC HRL/SWC EEC: 1.01
Notes
Reference Dose; Basis = NOAEL 0.013 mgfkg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


85JDAH "Organophosphorus Pesticides Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC
Press, Inc., 1974 Volume(issue)/page/year -,197,1974








CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Oxydemeton-methyl
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                           EPA-OGWDW
   August 2009
Page 164 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water



Amount
Released
154,227
0
0
n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration



Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0



Number of
States
19
0
0
%
PWSs/Sites/Sam
pies with
detects
0
0



Units
States
States
States
Minimum value of
Detects





Year
1997
2004
2004
Maximum
value of
Detects


Surface water chronic: 0.9 ug/L









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects


Units
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Ground water chronic: 0.006 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1.01
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







nsecticide (HSDB)
Value


-0.74

1.62E-13
1,000,000
39
Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS =Biodegrades Slowly







-------
Oxyfluorfen
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 165 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Oxyfluorfen
34731
42874033
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.003

0.003











5
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1986














Critical Effect

ncr. abs. liver weight; nonneoplastic lesions













Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0732


C

mg/L
(mg/kg-d)-'
(mg/kg-d)-1
(mg/kg-d)-1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


21
0.478
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 6 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 3.0
CAR HRL/SWC EEC: 0.067
Notes
Reference Dose
Reference Dose; Basis = NOEL 0.3 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4
7QG, UK) V.1- 1968- Volume(issue)/page/year 9,643,1991








EPA

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Oxyfluorfen
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 166 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water



Amount
Released
705,255
0
5
n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0



Number of
States
37
0
2
%
PWSs/Sites/Sam
pies with
detects
0
0



Units
States
States
States
Minimum value of
Detects





Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 7.1 ug/L
Non-cancer: 3.0
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Ground water chronic: 0.08 ug/L
Cancer: 0.067







Pesticide; herbicide
Value

46,800
4.73

8.23E-07
0.116
5
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = biodegrades sometimes/recalcitrant; PBT







-------
Perchlorate
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 167 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perchlorate
24310
14797730
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 1
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.0007






6







Units
mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

ug/L
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

2005






2000







Critical Effect

Radioactive iodide uptake inhibition (RAIU) in the
thyroid






Decreased newborn TSH







Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



See notes

mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-lnterimHA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y
15
4.9

Y/N
Y/N
ug/L
ug/L
ug/L






Teratogen



Prevalence Magnitude .,, „
9 8 NL!'L!
HRL Ratio(s)
NCHRL/UCMR90%: 0.35
Notes
Reference Dose
Reference Dose; Basis NOEL 0.007mg/kg-d
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; Brechner et al. 2000
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter
thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and
species differences in thyroid function (IRIS).



UMD
Interim Health Advisory; EPA is revisiting the intermin hHealth Advisory for perchlorate.
The HRL for the CCL differs from the Interim HA based on the RSC used in the health advisory (0.62)
and the default RSC (0.2) used for the CCL process.

1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Perchlorate
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 168 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
3,554



147



4.14



4



420



6.5



14



59



Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/UCMR 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer: 0.35
Amount Range
10K-500K

Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Smokeless rocket and jet propellant; explosives; analytical chemistry, etch ng and engraving agent (HSDB)
Value





200,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes





All use and env. fate data are for ammonium perchlorate.


-------
Perfluorooctane sulfonic acid
CCL 3 Contaminant Information Sheet
                                                                                               EPA-OGWDW
   August 2009
Page 169 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perfluorooctane sulfonic acid (PFOS)
12176
1763231
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
EPA/FR NOAEL
Supplemental NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










0.1
0.03


251


Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

















Critical Effect










Reduced F2 Body Weight
Decreased body weights, increased liver weights,
lowered serum total cholesterol, lowered
triiodothyronine (T3) concentration, and lowered
estradiol levels





Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-Provisional HA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.2
0.2

Y/N
Y/N
ug/L
ug/L
ug/L


January 2008







Prevalence Magnitude , „ ,
10 7 L' L
HRL Ratio(s)
NC HRL/MN MW MAX: 0.143
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
No Observed Adverse Effect Level in 2 generation reproductive study in rats. Supplemental Data - FR
October 18, 2000 (Volume 65, Number 202)] Perfluorooctyl Sulfonates; Proposed Significant New Use
Rule [Page 6231 9-62333]
Supplemental Data - Seacat et al., 2002, Toxicol. Sci. 68, 249-264. EPA Provisional HA:
http://www.epa.gOV/waterscience/criteria/d rinkinglpha-PFOA_PFOS.pdf
Lowest Observed Adverse Effect Level













Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf
Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). The HRL was
calculated in a d fferent manner than EPA's provisional HA because child exposure factors and
toxicokinetic adjustments were used to derive the provisional HA.

1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
    Perfluorooctane sulfonic acid
    CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                               EPA-OGWDW
   August 2009
Page 170 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of 90% of „„„, . „ . .
99% of Detects
Detects Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
Select New Jersey Water Systems
Select Minnesota municipal wells
Select Minnesota non-community wells
Select Minnesota private wells
Aggregate of above Minnesota wells
HRL Ratios (HRL/MN MW MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released


n
PWSs/Sites/Sa
mples
23
37
22
26
85



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
13
6
0
0
6



Number of
States


%
PWSs/Sites/Sam
pies with
detects
57%
16.2%
0%
0%
7.1%



Units
States
States
States
Range of Detects
(ug/L)
0.0042-0.019
ND-1.4
ND
ND
ND-1.4
Non-cancer: 0.143
Amount Range
10-500K
0
Units
Ibs/yr
Ibs/yr
Year
2002
2003 (EPA est.)





Year





Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Notes
Targeted Sampl ng 2006 - Targeted study "Determination of Perfluorooctanoic Acid (PFOA) in Aqueous Samples, Final Report." Jan 2007,
NJDEP, Division of Water Supply.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Cancer:





Estimate of zero as phased out.
Surface-active agents in aqueous media; chemical intermediate; in fire-fight ng applications, floor polish; metal plating baths; pest c de active ingred ent for ant bait traps. (HSDB)
Value

100,000



370

Units
length of time
L/kg
unitless
cm3/g
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = biodegrades sometimes/recalcitrant







-------
Perfluorooctanoic acid (PFOA)
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 171 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perfluorooctanoic acid (PFOA)
6614
335671
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value












0.46



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date












2006



Critical Effect












Increased maternal liver weight at term



Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-Provisional HA
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.4
1.1

Y/N
Y/N
ug/L
ug/L
ug/L


January 2008







Prevalence Magnitude
10 6
Scores based on supplemental data HRL Ratio(s)
NC HRL/MN MW MAX: 1.22
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data (BMDL10), Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA:
http://www.epa.goV/waterscience/criteria/d rinking/pha-PFOA_PFOS.pdf












Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf
Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). This value differs
from EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to
derive the provisional HA.

1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Perfluorooctanoic acid (PFOA)
   CCL 3 Contaminant Information Sheet

OCCURRENCE DATA1
                                                                                             EPA-OGWDW
   August 2009
Page 172 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of 90% of „„„, . „ . .
99% of Detects
Detects Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water


















Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
NJDEP - Jan 2007
Little Hocking, OH Municipal Wells (FW)
Select Minnesota municipal wells
Select Minnesota non-community wells
Select Minnesota private wells
Aggregate of above Minnesota wells
HRL Ratios (HRL/MN MW MAX)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released



n
PWSs/Sites/Sa
mples
23
No data
37
22
26
85




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
18

6
0
1
7




Number of
States



%
PWSs/Sites/Sam
pies with
detects
78

16.2%
0%
3.8%
8.2%




Units
States
States
States
Range of Detects
(ug/L)
<0.004 - 0.039
1.5-7.2
ND-0.9
ND
ND-0.67
ND-0.9
Non-cancer: 1.22
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year







Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Notes
Targeted study ' Determination of Perfluorooctanoic Ac d (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water
Supply.
Emmett, et al., 2006. J. Occ. Env. Med. Little Hocking, OH; data from 2002-2005.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Cancer:







Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire-fight ng applications, cosmetics, greases and lubricants, pa nts, polishes and adhesives (HSDB)
Value
180
27,000


9.10E-02

1
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
PBT; BST = biodegrades sometimes/recalcitrant







-------
Permethrin
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 173 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Permethrin
35815
52645531
Attribute Scores 3-model Categorical Prediction
Potency Severity
4 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.25
0.05

0.05
0.2
0.05










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1986



1999










Critical Effect
Neurotox (aggression, abnormal/ decreased movement),
increased body temperature. Q1* 0.0096 (mg/kg/day)-1.
See CAR
ncreased liver weight


Neurol.











Cancer Data
EPA Lifetime Cancer Risk, 10"*
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0096



3
mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1







1991






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


1,750
3.65
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 7 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 1,944
CAR HRL/SWC EEC: 4.05
Notes
Reference Dose; Basis = NOAEL 25 mg/kg-d; UF = 100.
Reference Dose; Basis = NOEL 5 mg/kd-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level; ATSDR MRL-int.
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data











EPA

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Permethrin
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 174 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total




Amount
Released
1,066,056
0
17,979




Units
Ibsfyr
Ibs/yr
Ibs/yr




Number of
States
48
0
7




Units
States
States
States




Year
1997
2004
2004












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 0.9 ug/L
Ground water chronic: 0 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 1,944
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 4.05







nsecticide (HSDB)
Value

178,000
6.5

1.87E-06
0.006

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF/BST






Notes
BF = biodegrades fast; BST = biodegrades sometimes/reca c trant







-------
Profenofos
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 175 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Profenofos
34318
41198087
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005




0.0004





0.05



162
Units
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1990










Critical Effect
Inhibition of plasma & RBC ChE activity










Blood - other changes, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - true
cholinesterase



Behavioral - somnolence (general depressed activity),
Behavioral - tremor, Gastrointestinal - changes in structure
or function of salivary glands
Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.35

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
86 Li
HRL Ratio(s)
NC HRL/SWC EEC: 3.5
Notes
Reference Dose; Basis = NOEL 0.005 mg*g-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 12,781,1987
Supplemental Data


TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959- Volume(issue)/page/year 73,16,1984









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Profenofos
   CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                            EPA-OGWDW
   August 2009
Page 176 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water



Amount
Released
879,776
0
255
n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0



Number of
States
14
0
1
%
PWSs/Sites/Sam
pies with
detects
0
0



Units
States
States
States
Minimum value of
Detects





Year
1997
2004
2004
Maximum
value of
Detects
Not Detected
Not Detected
Surface water chronic: 0.1 ug/L
Non-cancer: 3.5
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects


95% of
Detects
Not Detected
Not Detected
Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Ground water chronic: 0.03 ug/L
Cancer:







Pesticide, insecticide, acaricide (HSDB)
Value


4.68

2.21 E-08
28
9
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = biodegrades sometimes/recalcitrant; PBT







-------
Quinoline
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 177 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Quinoline
3467
91225
Attribute Scores
Potency Severity
7 8
Prevalence Magnitude
7 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.001
3

B2

mg/L
(mg/kg-d)-1
(mg/kg-d)"1


2001


2001






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y



0.01
Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
L?-L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data




IRIS
IRIS

Hirao et al., 1976; oral study in rats


CACART, EPA, RAIS

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Quinoline
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 178 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

62
28,629
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
8
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year

2004
2004
Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical intermed ate; pharmaceutical (anti-malarial); flavoring (HSDB)
Value

1,837
2.03

1.67E-06
6,110

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = Biodegrades Fast with Acclimation







-------
RDX
CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 179 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
RDX
5404
121824
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.003
0.003
0.003
0.03






40




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1988
2006

6/1995











Critical Effect

nflammation of the prostate.









Cardiac - other changes, Blood - pigmented or nucleated
red blood cells, Biochemical - Enzyme inhibition, induction,
or change in blood or tissue levels - transaminases




Cancer Data
EPA Lifetime Cancer Risk, 10J
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification
0.03
0.11

c

mg/L
(mg/kg-d)-1
(mg/kg-d)-1


1988


1988






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y
0.1
21
0.3
Y/N
Y/N
mg/L
ug/L
ug/L


2006



Teratogen



Prevalence Magnitude
5 5 Li
HRL Ratio(s)
NCHRL/STORET90%: 0.092
CARHRL/STORET90%: 0.0013
Notes
Reference Dose
Reference Dose; Basis NOEL 0.3 mg/kg-d. U.S. DOD, 1983
Reference Dose
Reference Dose
Int-Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in rat; NTIS National Technical Information Service.
(Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year AD-A092-531
Supplemental Data




EPAHA





EPA; RAIS
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   RDX
   CCL 3 Contaminant Information Sheet
                                                                                        EPA-OGWDW
   August 2009
Page 180 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental water data
STORE!

HRL Ratios (HRL/STORET 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1E, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



n
PWSs/Sites/Sa
mples
23



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
23



Number of
States



%
PWSs/Sites/Sam
pies with
detects
100



Units
States
States
States
Minimum value of
Detects
15

Non-cancer: 0.092
Amount Range
>500K - 1 M
>1M-10M
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects
270









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects
140
90% of
Detects
229
Units
ug/L

Cancer: 0.0013



Notes






High explosive
Value

195.4
0.87

6.30E-08
59.7

Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = biodegrades fast with acclimation







-------
sec-Butyl benzene
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 181 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
sec-Butylbenzene
5904
135988
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











4.42

2,240


Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Behavioral -alteration of classical conditioning




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



10.3

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
3 6 NLi
HRL Ratio(s)
NCHRL/NCODR1 90%: 1.03
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 24-week oral rat study; VCVGH "Vrednie chemichescie
veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated
hydrocarbons) Bandman A.L. etal., Chimia, 1990. Volume(issueXpage/year -,179,1990
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   sec-Butyl benzene
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 182 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water

12,343
22,974


28
34


0.227
0.148


0.03
0.1


19.8
22


0.7
0.6


10
4.6


19.8
22

Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NCOD R1 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
4,309


Amount
Released



# PWSs/Sites
sampled

25


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects

0.58


Number of
States



% PWSs/Sites
with detects

0.005


Units
States
States
States
Minimum value of
Detects

Non-cancer: 1.03
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



11


Year



Maximum
value of
Detects

0.39


2.81


11


Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Solvent for coating compositions, organic synthesis, plasticizer, and surface active agents (HSDB)
Value
15
7,200
4.57

1.80E-02
17.6
15
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = biodegrades slowly







-------
Strontium
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 183 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Strontium
18848
7440246
Attribute Scores 3-model Categorical Prediction
Potency Severity
3 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value

0.6
0.6
0.6
2











Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1992
2006

2004











Critical Effect

Rachitic bone


Musculo-skeletal effects











Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



D

mg/L
(mg/kg-d)-1
(mg/kg-d)-1





1993






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


20
4,200

Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude
10 10 Li
HRL Ratio(s)
NCHRL/NIRS90%:3.88
Notes
Reference Dose
Reference Dose; Storey, 1961 ; Marie et al., 1985; Skoryna, 1981; UF = 300; Rat; Basis NOAEL = 190
mg/kg-d
Reference Dose
Reference Dose; IRIS
Minimal Risk Level; UF = 30; MRL-Int
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were
identified for potency scoring.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Strontium
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 184 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water



989



980



99.1



1.5



43,550



178



1,080



7,340
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer: 3.88
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data are for strontium carbonate: In pyrotechnics; steel production; catalyst; lead scavenger (HSDB); naturally-occurring
Value





11

Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BST






Notes
assumed persistent; All use and env. fate data are for strontium carbonate; BST = biodegrades sometimes/recalcitrant







-------
Tebuconazole
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 185 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tebuconazole
69191
107534963
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.029




0.03









1,000
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2008




1994










Critical Effect
Decreased body weights, absolute brain weights, brain
measurements and motor activity in offspring














Behavioral - food intake (animal)
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification



C

mg/L
(mg/kg-d)"1
(mg/kg-d)-1





2008






Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



210

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
96 L' L
HRL Ratio(s)
NC HRL/GWC EEC: 9.09
Notes
Reference Dose; Basis = LOAEL 8.8 mg/kg-d; UF = 300. Federal Register: May 14, 2008 (Volume
74, Number 94), pp 27748-27756.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data


Oral study- rabbit; NTIS Nationa Technical Information Service. (Springfield, VA 22161) Formerly U.S.
Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0545183




OPP; 73 FR No. 94, pp 27748-27756.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Tebuconazole
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 186 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total




Amount
Released
478,568





Units
Ibs/yr
Ibs/yr
Ibs/yr




Number of
States
16





Units
States
States
States




Year
1997













Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 14 ug/L
Ground water chronic: 23.1 ug/L

HRL Ratios (HRL/GWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 9.09
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







Fungicide (HSDB)
Value


3.7

1.45E-10
36
9
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
PBT; BST = biodegrades sometimes/recalcitrant







-------
Tebufenozide
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 187 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tebufenozide
69514
112410238
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 6
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.018




0.02





8.7




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999




2003










Critical Effect
Growth retardation, alterations in hematology
parameters, changes in organ weights, and
histopathological lesions in the bone, spleen and liver




Effect on erythrocytes, periferal hemolytic anaemia. Gross
and histopathologica lesions in the spleen (congestion,
pigment, and extra-medullary haematopoiesis)





Blood - normocytic anemia, Blood - thrombocytopenia




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



126

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
9 5 Li
HRL Ratio(s)
NC HRL/SWC EEC: 8.4
Notes
Reference Dose; Basis NOAEL = 1 .8 mg/kg-d, UF = 100. Federal Register 64 FR, No. 203, pp
56690-56697, October 21, 1999.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 1-year study in dog; FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year 64, 16851, 1999
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Tebufenozide
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 188 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
104,413





Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
17





Units
States
States
States



Year
1997











Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 15 ug/L
Ground water chronic: 1.19ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.4
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







nsecticide (HSDB)
Value


4.25

1.26E-08
0.83
11
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
PBT; BST = biodegrades sometimes/recalcitrant







-------
Tellurium
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 189 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tellurium
23035
13494809
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 7
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










25




20
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mgflsg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect










Maternal toxicity




Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer

Y

175

Y/N
Y/N

ug/L
ug/L






Teratogen



Prevalence Magnitude
49 Li
HRL Ratio(s)
NCHRL/NIRS 90%: 0.673
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; No Observed Effect Leve ; Johnson et al., 1988
Lowest Observed Adverse Effect Level
Supplemental Data


Mouse; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure,"
Izmerov, N.F., et al., Moscow, Centre of Internatonal Projects, GKNT, 1982 Volume(issue)/page/year -
,107,1982








UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Tellurium
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 190 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water



989



4



0.4



15



370



22



260



360
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer: 0.673
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data are for sodium tellurite: Bacteriology, medicine (HSDB); naturally-occurring
Value







Units
length of time
L/kg
unitless
L/kg
unitless
mg/L

Degradation
Code
BST






Notes
assume persistent; All use and env. fate data are for sodium tellurite; BST = biodegrades sometimes/recalcitrant







-------
Terbufos
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 191 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Terbufos
22585
13071799
Attribute Scores 3-model Categorical Prediction
Potency Severity
7 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic? NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005

0.00005
0.000025

0.0002










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date


2006


1989










Critical Effect
Plasma ChE inhibition















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification



D

mg/L
(mg/kg-d)"1
(mg/kg-d)"1





1988






Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer


0.002
0.35

Y/N
Y/N
mg/L
ug/L
ug/L


2006







Prevalence Magnitude
1 1 NL
HRL Ratio(s)
NC HRL/NAWQA 90% : 1.67
Notes
Reference Dose; Basis = NOAEL 0.005 mgrtsg-d; UF = 100.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data







Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for
potency scoring.




Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.

-------
      Terbufos
      CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                             EPA-OGWDW
   August 2009
Page 192 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300


0


0


Not Detected


Not Detected


Not Detected


Not Detected


Not Detected


Ambient Water Occurrence Data
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water

CAL DHS
STORE!
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T,,2, Half life
KOC, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118


Amount
Released
6,515,603

n
PWSs/Sites/Sa
mples


n
PWSs/Sites/Sa
mples
61
915
22


Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
0
#with Detects
0
11
0.31


Number of
States
37

%
PWSs/Sites/Sam
pies with
detects
0
0
%
PWSs/Sites/Sam
pies with
detects
0
1.2
0.0021


Units
States
States
States
Minimum value of
Detects


Minimum value of
Detects

0.1
Non-cancer: 1.67
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.56


Year
1997

Maximum value
of Detects
Not Detected
Not Detected
Maximum value
of Detects

3.2
0.017


0.21


0.56


Units for Mag No(es
data

ug/L
ug/L
ug/L


ug/L
ug/L National Reconnaissance
ug/L National Reconnaissance
ug/L National Aggregate
ug/L National Aggregate
Notes


Median value of
Detects


Median value of
Detects

0.185
95% of Detects
Not Detected
Not Detected
90% of Detects

0.202
Notes
ug/L
ug/L
Units for Mag
data
ug/L
ug/L
Cancer:



Pesticide Pilot Mentoring Program (USGS/EPA)

Notes
Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
ts.aspx





nsecticide (HSDB)
Value
38
500-5,000
4.48

2.40E-05
5.07
14
Units
days
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
BSA = biodegrades slowly with acclimation







-------
Terbufos sulfone
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 193 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Terbufos sulfone
37071
5607016
Attribute Scores
Potency Severity
7 3
Prevalence Magnitude
1 1
Scores based on parent Scores based on parent
HEALTH EFFECTS DATA1 - See parent Terbufos
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.00005















Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect
Plasma ChE inhibition















Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
IARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
Is contaminant on list of carcinogens?
Is the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



0.35

Y/N
Y/N

ug/L
ug/L











3-model Categorical Prediction
NL
HRL Ratio(s)
NC HRL/NAWQA 90% : 1 .67 (NAWQA data and HRL
for parent terbufos)
Notes
Reference Dose - FOR PARENT TERBUFOS
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Leve
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data












Drinking Water Equivalent Level
Based on data for parent terbufos

1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used.

-------
      Terbufos sulfone
      CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                              EPA-OGWDW
   August 2009
Page 194 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Finished Water Occurrence Data FOR TERBUFOS - PARENT
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
300


0
0
0

0


Minimum value of
Detects
Maximum value
of Detects
Median value of
Detects
90% of Detects
99% of Detects

Not Detected


Not Detected


Not Detected


Not Detected


Not Detected


Ambient Water Occurrence Data FOR TERBUFOS - PARENT
N AWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
FOR TERBUFOS - PARENT
CAL DHS
STORE!
PPMP finished water
PPMP ambient water
HRL Ratios (HRL/NAWQA 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
KOC, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
7,118



Amount
Released



n
PWSs/Sites/Sa
mples
61
915


22



Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects
0
11
2
0
0.31



Number of
States



%
PWSs/Sites/Sam
pies with
detects
0
1.2
0.9
0
0.0021



Units
States
States
States
Minimum value of
Detects

0.1


Non-cancer: 1.67
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



0.56



Year



Maximum value
of Detects

3.2
0.016

0.017



0.21



0.56



Units for Mag
data

ug/L
mg/L
mg/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

0.185


90% of Detects

0.202


Units for Mag No(es
data
ug/L
ug/L
ug/L
ug/L
Cancer:



Drinking water monitoring;
http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan
te.aspx

Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O-
ANALOGUE SULFONE
Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O-
ANALOGUE SULFONE
NAWQA data and HRL for Parent Terbufos



Pesticide degradate
Value
38



2.21 E-08

21
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with ace mation







-------
Thiodicarb
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 195 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Thiodicarb
38116
59669260
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.03




0.03










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1998




2000










Critical Effect
Extramedulary hematapoesis and decreased red blood cell
cholinesterase activity















Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0188


B2

mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


210
1.86
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 6 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 8.1
CAR HRL/SWC EEC: 0.07
Notes
Reference Dose; Basis NOEL = 3.3 mg/kg-d (males) and 4.5 mg/kg-d (females); UF = 100; chronic rat
study.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data











CACART; EPA

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Thiodicarb
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 196 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
821,267
0.05
1,430



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
27
1
3



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 26 ug/L
Ground water chronic: 0 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.1
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.07







nsecticide (HSDB)
Value


1.7

9.33E-07
35
36
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
Thiophanate-methyl
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 197 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Thiophanate-methyl
27753
23564058
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.08
0.08

0.08

0.08





1.2



2,270
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
2004
1986



1998










Critical Effect
Thyroid and liver effects and decreased body weight
Decreased body weight, decreased spermatogenesis and
histological evidence of hyperthyroidism









Endocrine - evidence of thyroid hypofunction, Endocrine -
changes in thyroid weight, Nutritional and Gross Metabolic
- weight loss or decreased weight gain



Sense Organs and Special Senses (Eye) - mydriasis
(pupillary dilation), Behavioral - somno ence (general
depressed activity), Behavioral - convulsions or effect on
seizure threshold
Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0116


C

mg/L
(mgftg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

560
3.02
Y/N
Y/N

ug/L
ug/L






Female & male reproductive toxicity



Prevalence Magnitude , „ ,
10 6 Li L
HRL Ratio(s)
NC HRL/SWC EEC: 45.9
CAR HRL/SWC EEC: 0.248
Notes
Reference Dose; Basis NOEL = 8 mg/kg-d; UF = 100; chronic dog study.
Reference Dose; Basis = NOEL 8 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; FEREAC Federal Register. (U.S. Government Printing Office,
Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 67,14944,2002
Supplemental Data


TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959- Volume(issue)/page/year 23,606,1972





OPP


EPA
CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Thiophanate-methyl
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 198 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
453,792
0
92



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
40
0
3



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 12.2 ug/L
Ground water chronic: 3.03 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 45.9
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.248







Fungicide (HSDB)
Value

14.32
1.4

2.94E-13
438.9

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BF






Notes
BF = biodegrades fast







-------
Toluene diisocyanate
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 199 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Toluene diisocyanate
29421
26471625
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD501
CTDJPN Lowest Oral LD501
RTECS Lowest Oral LD501
Value









30

85.7




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect









Burns throat immediately.

Related to Chronic Data - death




Cancer Data
EPA Lifetime Cancer Risk, 10"*
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


0.039

2B
mg/L
(mg/kg-d)"1
(mg/kg-d)-1






1999





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y


210
0.9
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,
10 7 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series.
(Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-251,1986
Supplemental Data






Applies to m ixture of 2,4- and 2,6- isomers.



CACART; IARC; OEHHA

Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Toluene diisocyanate
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 200 of 214
OCCURRENCE DATA

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released

1
129,143
# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States

1
31
% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>500M - 1 B
>500M - 1 B
Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





n plastics manufacture (NTP)
Value

9,114
3.74

1.11E-05
37.57
17
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
Tribufos
CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 201 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Tribufos
2814
78488
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 3
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.001
0.00003

0.00003







4.08



77
Units
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1988














Critical Effect
Plasma ChE inhibition










Gastrointestinal - other changes, Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels -
other hydrolases, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue evels - peptidases



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)"1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



7

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
98 Li
HRL Ratio(s)
NC HRL/SWC EEC: 3.89
Notes
Reference Dose; Basis = NOAEL 0.1 mg/kg-d; UF = 100.
Reference Dose; Basis NOAEL 0.1 mg/kg-d; Abou-Donia etal., 1979
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 43 week study in rodent; FATOAO Farmakologiya i Toksikologiya
(Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.2- 1939- Volume(issue)/page/year 38,96,1975
Supplemental Data


85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986 Volume(issue)/page/year -,1188,1986









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Tribufos
   CCL 3 Contaminant Information Sheet
OCCURRENCE DATA1
                                                                                            EPA-OGWDW
   August 2009
Page 202 of 214

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data
PPMP ambient water
PPMP finished water




Amount
Released
4,918,265
4
7
n
PWSs/Sites/Sa
mples


OPP Estimated Environmental Concentration




Units
Ibsfyr
Ibs/yr
Ibs/yr
#with Detects
0
0




Number of
States
16
1
1
%
PWSs/Sites/Sam
pies with
detects
0
0




Units
States
States
States
Minimum value of
Detects






Year
1997
2004
2004
Maximum
value of
Detects


Surface water chronic 1.8ug/L












Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Median value of
Detects


95% of
Detects


Units for Mag
data
ug/L
ug/L
Notes
Pesticide Pilot Montoring Program (USGS/EPA)

Ground water chronic 0 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 3.89
Amount Range
10K-500K
10K-500K
Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer:







nsecticide; cotton defoliant (HSDB)
Value

1,888
5.7

2.94E-07
2.3

Units
ength of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
code
BF






Notes
BF = biodegrades fast







-------
Triethylamine
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 203 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Triethylamine
5379
121448
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value











1



460
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
















Critical Effect











Brain and Coverings - other degenerative changes



Details of toxic effects not reported other than lethal dose
value
Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)"1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



2.33

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude
10 9
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 30-week oral rat study; WDZAEK Weisheng Dulixue Zazhi.
Journal of Health Toxicology. (Weisheng Du ixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai,
Beijing, Peop. Rep. China) V.1- 1987 Volume(issue)/page/year 4,45,1990
Supplemental Data


AMIHBCAMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU. Volume(ssue)/page/year 4,119,1951









Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Triethylamine
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 204 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released

12,000
1,167,219
# PWSs/Sites
sampled





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects





Number of
States

14
35
% PWSs/Sites
with detects





Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range
>10M-50M
>10M-50M
Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year

2004
2004
Maximum
value of
Detects













Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Chemical intermed ate; stabilizer; in herbicides/pest c des; in consumer products; food addit ve; photographic chemical; in carpet c eaners (HSDB)
Value

107.2
1.45

1.49E-04
73,700
46
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BSA






Notes
PBT; BSA = biodegrades slowly with acclimation







-------
Triphenyltin hydroxide (TPTH)
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 205 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Triphenyltin hydroxide (TPTH)
2738
76879
Attribute Scores 3-model Categorical Prediction
Potency Severity
8 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.0003




0.0005





0.15




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date
1999




1970










Critical Effect
Decreased white blood cells










Blood - changes in other cell count (unspecified), Blood -
changes in leukocyte (WBC) count




Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

18.3


B2

mg/L
(mg/kg-d)-'
(mg/kg-d)-1
(mg/kg-d)-1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

2.1
0.0019
Y/N
Y/N

ug/L
ug/L






Teratogen; Developmental



Prevalence Magnitude
10 6
HRL Ratio(s)
NC HRL/SWC EEC: 0.33
CAR HRL/SWC EEC: 0.0003
Notes
Reference Dose; OPP RED
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; 90-day study in guinea pig; FCTXAV Food and Cosmetics
Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year4,35,1966
Supplemental Data











EPA; CACART
UMD; CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used.

-------
   Triphenyltin hydroxide (TPTH)
   CCL 3 Contaminant Information Sheet
                                                                                            EPA-OGWDW
   August 2009
Page 206 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total





Amount
Released
660,971
0
0





Units
Ibsfyr
Ibs/yr
Ibs/yr





Number of
States
26
0
0





Units
States
States
States





Year
1997
2004
2004















Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic 6.4 ug/L
Ground water chronic 0 ug/L
Notes


HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 0.33
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.0003







Pesticide (NTP)
Value

2,000
3.53

4.26E-07
0.4

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code







Notes








-------
Urethane
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 207 of 214
Contaminant
Substance Key:
Contaminant ID (CASRN):
Urethane
2189
51796
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 9
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value










0.9
78




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mgJkg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date










2005





Critical Effect










Decreased survival
Liver - changes in liver weight, Kidney, Ureter, Bladder -
changes in bladder weight, Blood - changes in leukocyte
(WBC) count




Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification


1

2B
mg/L
(mg/kg-d)-1
(mg/kg-d)"1






1987





Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

6.3
0.035
Y/N
Y/N

ug/L
ug/L





Developmental
Teratogen



Prevalence Magnitude ,
7 6 L
HRL Ratio(s)
No water data
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data; Food and Chemical Toxicology 43 (2005) 1-19
Lowest Observed Adverse Effect Level; 1 3 week oral study in rats; NTPTR National Toxicology Program
Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NIH-96-
3937
Supplemental Data








Vol. 7, Suppl. 7; 1987

IARC; CACART; OEHHA
UMD
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Urethane
   CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 208 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (No water data)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log KOW, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler




Amount
Released

0
96,050
# PWSs/Sites
sampled





Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects





Number of
States

0
7
% PWSs/Sites
with detects





Units
States
States
States
Minimum value of
Detects

Non-cancer:
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002







Year

2004
2004
Maximum
value of
Detects













Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Paint ingredient (NTP)
Value


-0.15

6.40E-08
480,000
40
Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BS






Notes
PBT; BS = Biodegrades Slowly







-------
Vanadium
CCL 3 Contaminant Information Sheet
                                                                                          EPA-OGWDW
   August 2009
Page 209 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Vanadium
18882
7440622
Attribute Scores 3-model Categorical Prediction
Potency Severity
6 5
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value



0.007
0.003



1.8


960




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d

mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date




1992



2001







Critical Effect




Minor renal effects (altered renal function as indicated
by increased plasma urea, and mild histological
changes).



Kidney lesions and increases in plasma urea and uric acid







Cancer Data
EPA Lifetime Cancer Risk, 104
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification





mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



21

Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude , „ ,
10 8 Li L
HRL Ratio(s)
NCHRL/NIRS90%:0.913
Notes
Reference Dose
Reference Dose
Reference Dose
Reference Dose; HEAST
Minimal Risk Level; MRL-Int; UF = 100
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data; IOM 2001 Dietary Reference ntakes
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level; Domestic mammal
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Vanadium
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 210 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water



989



146



14.76



3.1



70.4



7.27



23



45
Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total
Supplemental Water Data

HRL Ratios (HRL/NIRS 90%)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler



Amount
Released



# PWSs/Sites
sampled




Units
Ibs/yr
Ibs/yr
Ibs/yr
#with Detects




Number of
States



% PWSs/Sites
with detects




Units
States
States
States
Minimum value of
Detects

Non-cancer: 0.913
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002






Year



Maximum
value of
Detects










Units for Mag
data

ug/L
ug/L
ug/L
ug/L

ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Median value of
Detects

99% of
Detects

Units for Mag
data

Cancer:



Notes





Use data are for vanadium pentoxide: Chemical intermediate; catalyst; (HSDB); naturally-occurring
Value





8,000

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
assumed persistent; All use and env. fate data are for vanad um pentoxide; BST = biodegrades sometimes/recalcitrant







-------
Vinclozolin
CCL 3 Contaminant Information Sheet
                                                                                             EPA-OGWDW
   August 2009
Page 211 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Vinclozolin
35005
50471448
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
Supplemental NOEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.012
0.025

0.025

0.01










Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date

1986



1995










Critical Effect
Histopathological les ons in the lungs, iver, ovaries &
eyes. Q1 * 0.0638 (mg/kg-day)-1 .Group C. See CAR















Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor (oral)
RAISHE Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0638




mg/L
(mg/kg-d)-1
(mg/kg-d)"1
(mg/kg-d)"1














Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer
Y
Y

84
0.549
Y/N
Y/N

ug/L
ug/L






Developmental



Prevalence Magnitude , „ ,
10 5 L' L
HRL Ratio(s)
NC HRL/SWC EEC: 8.94
CAR HRL/SWC EEC: 0.058
Notes
Reference Dose; Basis = NOAEL 1 .2 mg/kg-d; UF = 1 00.
Reference Dose; Basis = NOEL 2.5 mg/kg-d; UF = 100.
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
Supplemental Data
Lowest Observed Adverse Effect Level
Supplemental Data











EPA
CACART
Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Vinclozolin
   CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 212 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
































Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total



Amount
Released
121,959
0
0



Units
Ibsfyr
Ibs/yr
Ibs/yr



Number of
States
26
0
0



Units
States
States
States



Year
1997
2004
2004









Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes



Supplemental Water Data
OPP Estimated Environmental Concentration
Surface water chronic: 9.4 ug/L
Ground water chronic: 0 ug/L

HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T1n, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Non-cancer: 8.94
Amount Range


Units
Ibs/yr
Ibs/yr
Year
1998
2002



Cancer: 0.058







Fungicide (HSDB)
Value

289
3.1

1.33E-08
2.6

Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BST






Notes
BST = biodegrades sometimes/recalcitrant







-------
Ziram
CCL 3 Contaminant Information Sheet
                                                                                           EPA-OGWDW
   August 2009
Page 213 of 214
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Ziram
5947
137304
Attribute Scores 3-model Categorical Prediction
Potency Severity
5 8
HEALTH EFFECTS DATA1
Non-cancer data
EPA OPP RfD
EPA IRIS (ITER) RfD
EPA HA RfD
RAISHE RfD
ATSDR (ITER), MRL
JMPR, maximum ADI
CEDIADI, ADI
ITER, TDI
Supplemental RfD-like value
CTDJPN Highest Chronic NOEL
NOAEL
RTECS Lowest Oral Chronic LOAEL
Supplemental LOAEL
HSDB Lowest Oral LD50
CTDJPN Lowest Oral LD50
RTECS Lowest Oral LD50
Value
0.016




0.003




1.6
1




Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d


mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg
Date





1996










Critical Effect
Decreased body weight gain




Decreased body weight





Gastrointestinal - hypermotility, diarrhea




Cancer Data
EPA Lifetime Cancer Risk, 104
OPP Slope Factor
OEHHA Slope Factor (oral)
EPA Carcinogen classification
ARC Carcinogen Classification

0.0611

Suggestive (not
quantified)
3
mg/L
(mg/kg-d)-1
(mg/kg-d)-1












Other Supporting Data
s contaminant on list of carcinogens?
s the contaminant on a list of reproductive
toxins?
EPAHA-DWEL
Health Reference Level (HRL)2
Health Reference Level (HRL)2 cancer



112
0.57
Y/N
Y/N

ug/L
ug/L










Prevalence Magnitude ,
10 7 L
HRL Ratio(s)
NC HRL/SWC EEC: 56.6
CAR HRL/SWC EEC: 0.288
Notes
Reference Dose; Basis = NOAEL 1 .6 mg/kg-d; UF = 1 00.
Reference Dose
Reference Dose
Reference Dose
Minimal Risk Level
Acceptable Daily Intake; Group ADI for Ferbam and Ziram
Acceptable Daily Intake
Tolerable Daily Intake
Supplemental Data
No Observed Effect Level
OPP
Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide
Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70,
Japan) V.1- 1976- Volume(issue)/page/year 17,3155,1992
Supplemental Data












Drinking Water Equivalent Level


1 Bolded data indicate value was used in attribute scoring
2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used.

-------
   Ziram
   CCL 3 Contaminant Information Sheet
                                                                                         EPA-OGWDW
   August 2009
Page 214 of 214
OCCURRENCE DATA1

# PWSs/Sites
sampled
#with Detects
% PWSs/Sites
with detects
Minimum value of
Detects
Maximum
value of
Detects
Median value of
Detects
90% of
Detects
99% of Detects
Finished Water Occurrence Data
UCMR finished water
NCOD Round 1 finished water
NCOD Round 2 finished water
NIRS finished water
























Ambient Water Occurrence Data
NAWQA ambient water
NREC ambient surface water
NREC ambient ground water
NREC ambient surface water
NREC ambient ground water
Application/Release
NCFAP Pesticide Application - total
TRI Release - surface water
TRI Release - total




Amount
Released
1,992,552





Units
Ibsfyr
Ibs/yr
Ibs/yr




Number of
States
29





Units
States
States
States




Year














Units for Mag
data

ug/L
ug/L
ug/L


ug/L
ug/L
ug/L
ug/L
ug/L
Notes







National Reconnaissance
National Reconnaissance
National Aggregate
National Aggregate
Notes


Supplemental Water Data
OPP Estimated Environmental Concentration
HRL Ratios (HRL/SWC EEC)
Production
CUSIUR Production Data
Use
Environmental Fate Parameters
T172, Half life
Koc, Organic Carbon Partition Coefficient
log Kow, Octanol Water Partition Coeff.
Kd, Distribution coefficient
HLC, Henry's Law Constant
Water Solubility
% water PBT profiler
Surface water chronic: 1 .98 ug/L
Non-cancer: 56.6
Amount Range
>500K - 1 M
>500K - 1 M
Units
Ibs/yr
Ibs/yr
Year
1998
2002



Ground water chronic: 0.03 ug/L
Cancer: 0.288







Synthetic rubber chemical (NTP); fungicide
Value




6.20E-10


Units
length of time
L/kg
unitless
L/kg
atm-m3/mol
mg/L

Degradation
Code
BFA






Notes
BFA = Biodegrades Fast with Acclimation







-------