vvEPA United States Environmental Protection Agency Contaminant Information Sheets for the Final CCL 3 Chemicals ------- Office of Water (4607M) EPA815-R-09-012 August 2009 www.epa.gov/safewater ------- EPA815-R-09-012 Final CCL 3 Chemicals August 2009 EPAOGWDW Contaminant Information Sheets Page 1 of 214 Contaminant Information Sheets for the Final CCL 3 Chemicals This File contains Contaminant Information Sheets for 106 chemical contaminants that are listed on the final third Contaminant Candidate List (CCL 3). (Note: there are 104 chemical entries listed in the Federal Register Notice for the final CCL 3; cyanotoxins are listed as a group. In this file, there are information sheets on three individual cyanotoxins that were evaluated in the CCL 3 process (Anatoxin-a, Cylindrospermopsin, and Microcystin-LR)). These sheets summarize information about the chemicals that were considered during the development of the CCL 3. The sheets are in alphabetical order. Each information sheet is two pages in length. There is an index/bookmark in this PDF file that can be used to negotiate the file. The bookmarks are hyperlinked. You can find the contaminant name in the bookmark list, click on it, and the hyperlink will take you to that file. ------- EPA815-R-09-012 Final CCL 3 Chemicals August 2009 EPA OGWDW Contaminant Information Sheets Page 2 of 214 This page intentionally left blank for double-sided printing ------- 1,1,1,2-Tetrachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 3 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 1,1,1 ,2-Tetrachloroethane 9105 630206 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.03 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 Critical Effect Mineralization of the kidneys in males, hepatic clear cell change in females Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.1 0.026 C 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1989 1989 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1 210 1 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude , „ 36 L HRL Ratio(s) NC HRL/NCOD R1 90%: 67.7 CAR HRL/NCOD R1 90%: 0.323 Notes Reference Dose Reference Dose; Basis LOAEL = 89.3 mg/kg-d (NTP 1983) Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLswere calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- 1,1,1,2-Tetrachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 4 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,956 24,127 31 51 0.18 0.21 0.06 0.2 9.2 18 0.59 0.5 3.1 1.55 9.2 18 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released 36 12,088 # PWSs/Sites sampled 4 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.09 Number of States 2 7 % PWSs/Sites with detects 0.011 Units States States States Minimum value of Detects Non-cancer: 67.7 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.0644 Year 2004 2004 Maximum value of Detects 0.0275 0.0644 0.0644 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.323 Notes Chemical intermed ate (NTP) Value 60 93-399 2.66 2.70E-03 1,100 22 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- 1,1-Dichloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 5 of 214 Contaminant Substance Key: Contaminant ID (CASRN): 1,1-Dichloroethane 2647 75343 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Decreased body weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0057 C mg/L (mg/kg-d)-1 (mg/kg-d)-1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 1,400 6.14 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 77 Li HRL Ratio(s) NC HRL/NCOD R1 90%: 250 CAR HRL/NCOD R1 90%: 1.1 Notes Reference Dose Reference Dose Reference Dose Reference Dose; basis NOAEL 71 4 mg/kg-d, UF = 3,000; Muralidhara, et al, 2001 . Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,1-Dichloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 6 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,483 24,808 233 184 1.14 0.74 0.01 0.0013 500 159 1.2 1 5.6 3.8 27 25 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,350 Amount Released 63 17,368 # PWSs/Sites sampled 135 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3.103 Number of States 3 5 % PWSs/Sites with detects 0.008 Units States States States Minimum value of Detects Non-cancer: 250 Amount Range >1M-10M >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 39 Year 2004 2004 Maximum value of Detects 0.05 0.316 5.6 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 1.1 Notes Solvent (NTP) Value 38 30 1.79 5.62E-03 5040 46 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- 1,2,3-Trichloropropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 7 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 1 ,2,3-Trichloropropane 3817 96184 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.006 0.006 0.006 0.06 5.71 22.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 1992 1987 Critical Effect Alterations in clinical chemistry & reduction in RBC mass Hepatic Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 7 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.2 42 0.005 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 3 6 Li HRL Ratio(s) NC HRL/NCOD R2 90%: 2.1 CAR HRL/NCOD R2 90% : 0.00025 Notes Reference Dose Reference Dose; NTP, 1983 ; rats; UF = 1,000; Basis NOAEL = 8 mg/kg-d Reference Dose; F' 89 Reference Dose Minimal Risk Level; Int-MRL; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; ITER NOAEL Lowest Observed Adverse Effect Level; 1 7 week oral study in rats; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP- TR-384,1993 Supplemental Data HEAST CACART, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2,3-Trichloropropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 8 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 17,392 24,088 44 19 0.25 0.079 0.1 0.03 112 3,000 0.92 0.5 6 20 112 3,000 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total 4,309 Amount Released 282 9,053 43 Units Ibs/yr Ibs/yr Ibs/yr 1.0 Number of States 1 2 0.05 Units States States States 2.92 Year 2004 2004 0.4 0.97 2.92 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data Nominated data from NJDEP HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler NJ study: Detected in excess of health-based drinking water guidance value in 30 of 2,640 private wells and 11 of approximately 260 community water systems between 1999 and 2004 in NJ SOC Waiver Program sampling. Non-cancer: 2.1 Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.00025 Notes Paint ingredient (NTP) Value 38 77-95 2.27 3.43E-04 1,750 25 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- 1,3-Butadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 9 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 1,3-Butadiene 4578 106990 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 10 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3.4 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)-' 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.0103 Y/N Y/N ug/L ug/L Teratogen List 3-model Categorical Prediction L HRL Ratio(s) No Water Data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Vol.71; 1999 EPA, IARC, CACART, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Butadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 10 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 493 1,964,956 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 8 34 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber chemical (NTP) Value 7-28 288 1.99 7.40E-02 735 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- 1,3-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 11 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 1,3-Dinitrobenzene 4045 99650 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.0001 0.0001 0.0005 1.73 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 1995 Critical Effect Increased spleen weight Hemato. Endocrine - changes in spleen weight, Blood - methemoglobinemia-carboxyhemoglobin Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.005 0.7 Y/N Y/N mg/L ug/L ug/L 2006 male Prevalence Magnitude 1 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Cody etal., 1981; Rats; UF = 3,000; Basis NOAEL = 0.4 mg/kg-d Reference Dose Reference Dose; IRIS Minimal Risk Level; Int-MRL; UF = 1 ,000 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90 day oral study in rats; TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year 30,200,1996 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,3-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 12 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2 528,962 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 1 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (HSDB) Value 38 150 1.49 4.90E-08 533 37 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- 1,4-Dioxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 13 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 1,4-Dioxane 5539 123911 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.3 0.011 0.027 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 1999 1987 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 700 3 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 9 8 L HRL Ratio(s) NC HRL/CAL DHS 90%: 92.1 CAR HRL/CAL DHS 90%: 0.395 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; ATSDR MRL-int = 0.6 mg/kg-d Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; IARC; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,4-Dioxane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 14 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental water data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 89,521 821,067 n PWSs/Sites/Sa mples 869 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 89 Number of States 7 22 % PWSs/Sites/Sam pies with detects 10.2 Units States States States Minimum value of Detects 0.001 Non-cancer: 92.1 Amount Range >1M-10M >1M-10M Solvent (NTP); so Value 1 -0.27 4.80E-06 1,000,000 Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects 46.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 2.1 90% of Detects 7.6 Units ug/L Cancer: 0.395 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx vent stabilizer Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = biodegrades slowly ------- 17 alpha-Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 15 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 17 alpha-Estradio 81747 57910 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 9 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/Kolpin MAX: 4.7 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 17 alpha-Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 16 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, et al., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 5.7 Units States States States Minimum value of Detects Non-cancer: 4.7 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.074 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.03 90% of Detects Units for Mag data ug/L Notes National Surface Water Reconnaissance Kolpin, D.W., et al., 2002. Env. Sci. STechnol., 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 38 3.94 3.9 11 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- 1-Butanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 17 of 214 Contaminant Substance Key: Contaminant ID (CASRN): 1-Butanol 2563 71363 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Hypoactivity, ataxia Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 700 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 10 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S. EPA, 1986; Basis NOAEL = 125 mg/kg-d, UF = 1,000; oral study in rats. Reference Dose Reference Dose; IRIS Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30 day oral study in rats; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 135,3122,2002 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1-Butanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 18 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 22,011 17,648,846 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 20 44 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Paint solvent; chemical intermediate; food additive (HSDB) Value 2.443 0.88 8.82E-06 63200 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- 2-Methoxyethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 19 of 214 Contaminant Substance Key: Contaminant ID (CASRN): 2-Methoxyethanol 4803 109864 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 Units mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reproductive effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 21 Y/N Y/N ug/L ug/L Teratogen / developmental, male Prevalence Magnitude 9 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Unpublished NTP study - Gulati, et al, 1990. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD / CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Methoxyethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 20 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 14,390 153,774 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 3 16 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Consumer products; synthetic Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin Lot on (NTP) Value 1 -0.77 3.30E-07 1000000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with acclimat on ------- 2-Propen-1-ol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 21 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 2-Propen-1-ol 4596 107186 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.005 2.5 52 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Impaired renal function & increased relative liver, spleen & kidney weights Liver - liver function tests impaired, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Metabolism (Intermediary) - Plasma proteins not involvinq coaqulation Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 8 8 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Carpanini et al., 1978; Rat; UF = 1,000; Basis NOAEL = 4.8 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; Rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,121,1994 Supplemental Data Rabbit; NTIS National Technical Information Serv ce. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0571508 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-Propen-1-ol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 22 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 10,971 604,872 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 4 13 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Manufacture of flavorings, perfumes; chemical intermediate (HSDB) Value 1.325 0.17 5.00E-06 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- 3-Hydroxycarbofuran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 23 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 3-Hydroxycarbofuran 25541 16655826 Attribute Scores 3-model Categorical Prediction Potency Severity 7 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00006 7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Inhibition of brain cholinesterase in pups - The RfD for the parent covers the toxicity of the metabolite Decreased body wt. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.42 Y/N Y/N W/L W/L Prevalence Magnitude 2 7 Li HRL Ratio(s) NC HRL/NCOD R2 90%: 0.191 Notes Reference Dose; Basis = BMDL10 0.03 mg/kg-d; UF = 500. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PCBPBS Pesticde Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year 3,435,1973 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 3-Hydroxycarbofuran CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 24 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,700 18 0.14 1 66.3 2.2 2.2 66.3 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,539 Amount Released n PWSs/Sites/Sa mples 1 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 1 0.022 Number of States % PWSs/Sites/Sam pies with detects 0 0.4 0.07 Units States States States Minimum value of Detects Non-cancer: 0.191 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.07 Year Maximum value of Detects 0 0.062 0.07 0.07 0.07 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data ug/L ug/L Cancer: Notes Pesticide degradate Value 38 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- 4,4'-Methylenedianiline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 25 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): 4,4'-Methylenedianiline 4202 101779 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.08 4.34 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 Critical Effect ntense liver degenerative lesions, hyperplasia of the stroma Liver - fatty liver degeneration, Kidney, Ureter, Bladder - interstitial nephritis, Blood - normocytic anemia Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.25 1.6 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 560 0.022 Y/N Y/N ug/L ug/L Prevalence Magnitude , 7 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 5 week oral study in dogs; JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year 11,367,1991 Supplemental Data Slope factor withdrawn Vol. 39, Suppl. 7; 1987 IARC, CACART, OEHHA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4,4'-Methylenedianiline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 26 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 96,446 168,919 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 2 10 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; corrosion nhibitor; curing agent for polyurethanes (HSDB) Value 4,950 1.59 1.58E-11 1,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Acephate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 27 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acephate 31325 30560191 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0012 0.004 0.004 0.03 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 1990 Critical Effect Brain ChE inhibition Brain and Coverings - other degeneratve changes, Autonomic Nervous System - sympathomimetic, Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.4 0.0087 C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1988 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 8.4 4 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 7 L' L HRL Ratio(s) NC HRL/SWC EEC: 1.17 CAR HRL/SWC EEC: 0.556 Notes Reference Dose; Basis = NOAEL 0.12 mg/kg-d; UF = 100. Reference Dose; Basis = LOEL females = 0.15 mg/kg-d; LOEL males = 0.12 mg/kg-d; Adjusted Basis Value = LOAEL 0.0004 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(ssue)/page/year 43,342,1987 Supplemental Data EPA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acephate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 28 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 2,462,354 0 20,751 Units Ibsfyr Ibs/yr Ibs/yr Number of States 35 0 5 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 7.2 ug/L Ground water chronic: 0.02 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.17 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.556 nsecticide (HSDB) Value 21.8 -0.85 5.02E-13 818,000 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BF Notes BF = biodegrades fast ------- Acetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 29 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Acetaldehyde 2622 75070 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - changes in motoractivity (specific assay) Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/DBP ICR MED: 3.15 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issueXpage/year PB234-882; 22-wk guinea pig study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1988 1999 Vol. 36, Suppl. 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 23.3 Y/N Y/N ug/L ug/L Teratogen list IARC, EPA, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acetaldehyde CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 30 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR # PWSs/Sites sampled 236 #with Detects 27 % PWSs/Sites with detects 11.44 Minimum value of Detects Maximum value of Detects 18.3 Median value of Detects T.4 Mean value of Detects 8.04 Units for Mag data ug/L Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 370,815 14,683,890 n PWSs/Sites/Sa mples 8 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 % Samples with detects Number of States 31 38 % PWSs/Sites/Sam pies with detects 37.5 Minimum value of Detects Units States States States Minimum value of Detects 1 Non-cancer: 3.15 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 24 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Notes Notes ug/L ug/L ug/L Units for Mag data ug/L ug/L National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2 90% of Detects 4 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide; food additive; chemica intermediate (HSDB) Value 1.498 -0.34 6.68E-05 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Acetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 31 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acetamide 2411 60355 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification o.or 2B mg/L (mg/kg-d)-1 (mg/kg-d)-' Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.5 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 7 9 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 32 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2,754 1,202,667 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 3 7 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; solubilizer; plasticizer; stabilizer (HSDB) Value 5 -1.26 1.21E-08 2,250,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes BF = biodegrades fast ------- Acetochlor CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 33 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor 32393 34256821 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 5.45 Units mg/kg-d mg*g-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect Salivation, increased ALT & omithine carbamyl transferase; increases in triglyceride & decreased blood glucose levels; histopathological changes in kidneys & testes Brain and Coverings - other degenerative changes, Blood - methemoglobinemia-carboxyhemoglobin, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - dehvdroaenases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 140 Y/N Y/N ug/L ug/L Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQ 90% : 179 Notes Reference Dose Reference Dose; Basis NOAEL 2 mg*g-d; UF = 100. ICI, Inc., 1988a Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 42-day study in rat; PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, PI. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year 15,96,1990 Supplemental Data CACART Drinking Water Equ valent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetochlor CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 34 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 115 69 #with Detects 0 293 5.02 Number of States 35 % PWSs/Sites/Sam pies with detects 35.6 30.3 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects Minimum value of Detects 0.026 Non-cancer: 179 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 0.334 0.395 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.022 95% of Detects 0.002 0.061 90% of Detects 1.5 Units ug/L ug/L Units ug/L ug/L Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/ drinkingwater/Pages/Chemicalcontaminants.aspx Herbicide (HSDB) Value 4.3 98.5-239 3.03 5.4E-11 233 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast (half-life is for soil) ------- Acetochlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 35 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor ethanesulfonic acid (ESA) 79191 187022113 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 1 1 Scores based on parent HEALTH EFFECTS DATA1 - See Acetochlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 23 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced body weights and body weight gains in both sexes Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 161 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 205 (NAWQA data for acetochlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acetochlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 36 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data - FOR ACETOCHLOR - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data - FOR ACETOCHLOR - PARENT NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ACETOCHLOR ESA POP finished water FOR ACETOCHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples 377 n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 5 #with Detects 0 293 5.020 Number of States 35 % PWSs/Sites/Sam pies with detects 1.3 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects 0.02 Minimum value of Detects 0.026 Non-cancer: 205 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 0.02 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes FOR ACETOCHLOR - PARENT Median value of Detects Median value of Detects 0.022 95% of Detects 90% of Detects 1.5 Units ug/L Units ug/L ug/L Cancer: Notes Pesticide Data Program (USD A); 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx NAWQA data for acetochlor - parent Pesticide degradate Value Units length of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Acetochlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 37 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor oxani ic acid (OA) 79193 194992444 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 1 1 Scores based on parent HEALTH EFFECTS DATA1 - See Acetochlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 23 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced body weights and body weight gains in both sexes Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 161 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 205 (NAWQA data for acetochlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR OA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Acetochlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 38 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data FOR ACETOCHLOR - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data FOR ACETOCHLOR - PARENT N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water TRI Release - total Supplemental wate data FOR ACETOCHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters r,72, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 293 5.02 Number of States 35 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects 0.026 Non-cancer: 205 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes FOR ACETOCHLOR - PARENT Median value of Detects 0.022 90% of Detects 1.5 Units ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx NAWQA data for acetochlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Acrolein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 39 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Acrolein 4581 107028 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 0.0005 0.0005 0.5 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2003 12/1990 Critical Effect Decreased survival Hemato. Liver - liver function tests impaired, Kidney, Ureter, Bladder - other changes Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1995 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 3 7 Li L HRL Ratio(s) NC HRL/NAWQA 90% : 1 .03 Notes Reference Dose Reference Dose; Basis = NOAEL 0.05 mg/kg-d; UF = 100. Parent, et. al, 1S92a Reference Dose Reference Dose (IRIS) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,385,1994 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acrolein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 40 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 1,108 Amount Released 1 284,480 # PWSs/Sites sampled 2 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.18 Number of States 1 16 % PWSs/Sites with detects 1.3 Units States States States Minimum value of Detects Non-cancer: 1.03 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 3.4 Year 2004 2004 Maximum value of Detects 2.35 3.4 3.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Aquatic herbicide; rodenticide; industrial chemical (HSDB) Value 120-180 3 -0.01 1.22E-04 212,000 Units hours in water L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes pH = 7; BF = biodegradesfast ------- Alachlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 41 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Alachlor ethanesulfonic acid (ESA) 71246 142363539 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 157 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased incidence of clinical signs of toxicity in males and females and decreased body weight gains in males. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification 0.04 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,100 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, 93 NL Scores based on parent HRL Ratio(s) NC HRL/NAWQA 90% : 4,300 (NAWQA data for alachlor - parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP - FOR ALACHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data FOR ALACHLOR - PARENT Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Alachlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 42 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data - FOR ALACHLOR PARENT NAWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ALACHLOR ESA POP finished water POP finished water FOR ALACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,166 Amount Released n PWSs/Sites/Sa mples 79 233 n PWSs/Sites/Sa mples 8,112 2,111 568 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 76 #with Detects 3 361 7.9 Number of States % PWSs/Sites/Sam pies with detects 3.8 32.6 % PWSs/Sites/Sam pies with detects 0.0003 17.1 0.0008 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.24 0.0125 Non-cancer: 4,300 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 38.2 Year Maximum value of Detects 0.50 1.44 Maximum value of Detects 14 10.78 0.015 0.256 3.33 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 4.29 0.06 95% of Detects 90% of Detects 11.09 0.55 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USD A); 2001 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminant s.aspx NAWQA data for alachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- AlachlorOA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 43 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Alachlor oxanilic acid (OA) 79196 171262172 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.04 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 Y/N Y/N ug/L ug/L Prevalence Magnitude 93 Li Scores based on parent HRL Ratio(s) CAR HRL/NAWQA 90% : 1 .56 (NAWQA data for alachlor- parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FOR ALACHLOR - PARENT Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- AlachlorOA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 44 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data - FOR ALACHLOR PARENT NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ALACHLOR OA POP finished water POP finished water FOR ALACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,166 Amount Released n PWSs/Sites/Sa mples 137 411 n PWSs/Sites/Sa mples 8,112 2,111 568 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 21 #with Detects 3 361 r.9 Number of States % PWSs/Sites/Sam pies with detects 0.07 5.1 % PWSs/Sites/Sam pies with detects 0.0003 17.1 0.0008 Units States States States Minimum value of Detects 0.50 0.121 Minimum value of Detects 0.24 0.0125 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 38.2 Year Maximum value of Detects 0.50 0.392 Maximum value of Detects 14 10.8 0.015 0.256 3.33 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 4.29 0.06 95% of Detects 90% of Detects 11.09 0.55 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: 1.56 Notes Pesticide Data Program (USDA); 2001 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx NAWQA data for alachlor - parent Pesticide degradate Value Units ength of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- alpha-Hexachlorocyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 45 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): alpha-Hexachlorocyclohexane 6535 319846 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.008 1.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 9/2003 Critical Effect Hepatic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0006 6.3 2.7 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 56 0.006 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 3 Li HRL Ratio(s) NC HRL/NAWQA 90% : 949 CAR HRL/NAWQA 90%: 0.102 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; Basis NOAEL 0.8 mg/kg-d; UF = 1 00. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 56,137,1991 Supplemental Data IRIS EPA; RAIS; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- alpha-Hexachlorocyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 46 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,113 Amount Released # PWSs/Sites sampled 21 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.295 Number of States % PWSs/Sites with detects 0.0004 Units States States States Minimum value of Detects Non-cancer: 949 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.21 Year Maximum value of Detects 0.011 0.059 0.21 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.102 Notes Component of benzene hexachloride (BHC) former insecticide (HSDB) Value 1.2 641-1,995 3.8 6.70E-06 2 Units years L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes hydrolysis only, pH = 7; BST = biodegrades sometimes/reca citrant ------- Anatoxin-a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 47 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Anatoxin-a 80772 64285069 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Mortality Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 Y/N Y/N ug/L ug/L Prevalence Magnitude 9 8 L Scores based on supplemental data HRL Ratio(s) NC HRL/Cyano HABs MAX: -0.35 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis NOAEL 0.5 mg/kg-d. Astrachan, N.B. and B.G. Archer. 1981. Simplified monitoring of anatoxin-a by reverse-phase high performance liquid chromatography and the sub-acute effects of anatoxin-a in rats. In: The Water Environment: Algal Toxins and Health, W.W. Carmichael, Ed. Plenum Press, New York, NY. p. 437-446. Astrachan, N.B., B.G, Archer and D.R. Hilbelink. 1980, Evaluation of thesubacutetoxicity and teratogenicity of anatoxin- a. Toxicon. 18(5-6): 684-688. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Anatoxin-a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 48 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Prev: UCMR1 Meeting summary; Mag: CyanoHABs - The Florida Experience HRL Ratios (HRL/CyanoHABs MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 4 Units States States States Minimum value of Detects Non-cancer: -0.35 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects ~10 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L Cancer: Notes Prev: Lake Champlain, NY study; Mag: 2000 Florida study Cyanobacterial toxin Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Aniline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 49 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Aniline 2438 62533 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.007 0.007 2.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect Blood- effects; Spleen-effects spleen Blood - pigmented or nucleated red blood cells, Blood - methemoglobinemia-carboxyhemoglobin, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other esterases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.6 0.0057 0.0057 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 spleen Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 49 6 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 98 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Provisional value; 104-week chronic study in rat for aniline hydrochloride. CUT, 1982. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; CIIT.1982; Basis LOAEL 7.2 mg/kg-d; rat; UF = 1,000 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 12 week oral study in rats; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 24(7), 44,1 959 Supplemental Data from IRIS Vol. 27, Suppl. 7; 1987 EPA, CACART, OEHHA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Aniline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 50 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 1,903 937,263 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 7 20 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemica ; as solvent; synthesis of explosives, rubber accelerators, isocyanates (HSDB) Value 44.78 0.9 2.02E-06 36000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- Bensulide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 51 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Bensulide 9553 741582 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 271 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma & brain ChE inhibition, decreased body weight gain Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 6 Li HRL Ratio(s) NC HRL/SWC EEC: 0.224 Notes Reference Dose; Basis = NOAEL 0.5 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year-,C42,1991 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bensulide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 52 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 545,406 Units Ibsfyr Ibs/yr Ibs/yr Number of States 34 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 158 ug/L Ground water chronic: 1 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.224 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide (HSDB) Value 9.15E-09 15 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- Benzyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 53 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Benzyl chloride 4107 100447 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 26.6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cardiac - other changes, Gastrointestinal - necrotic changes, Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.02 0.17 0.17 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1989 Thyroid Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 62 0.2 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 75 L' L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V. 61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year 76,1231,1986; 26 week oral study in rats Supplemental Data 2B from IARC Lijinsky, 1986 CACART, EPA, RAIS, OEHHA, IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 54 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, etal., 2006 HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 259 18,750 n PWSs/Sites/Sa mples 12 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 Number of States 3 10 % PWSs/Sites/Sam pies with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data Notes Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185. Cancer: Chemical intermed ate (NTP) Value 517.8 2.3 4.11E-04 20 27 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Butylated hydroxyanisole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 55 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Butylated hydroxyanisole 28160 25013165 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.249 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1959 Critical Effect Liver - changes in liver weight Prevalence Magnitude 8 4 NLi HRL Ratio(s) NC HRL/NREC NA GW MED: 0.484 CAR HRL/NREC NA GW MED: 146 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1 -64, 1 924-86. Volume(issue);page/year 37,533,1 959 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0002 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Vol. 40, Suppl. 7, 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.581 175 Y/N Y/N ug/L ug/L CACART; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butylated hydroxyanisole CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 56 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal.,2002 Focazio, etal., 2008 HRL Ratios (HRL/NREC NA GW MED) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 85 # Sam pies Amount Released n PWSs/Sites/Sa mples 2 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2.4 % Samples with detects 3 0.61 Number of States % PWSs/Sites/Sam pies with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.484 Amount Range >500K-1M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.2 Not detected 0.1 Median value of Detects 0.2 1.2 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: 146 Notes National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci. &Technol.,36(6), pp. 1202-1211. A national reconnaissance for Pharmaceuticals and other organic wastewater contaminants in the United States ~ II. Untreated drinking water sources. Focazio, etal., 2008. Sci. Tot. Env., 402(2-3), pp. 201- 216. Food additive (antoxidant) (HSDB) Value 38 days 1,390 3.5 1.17E-06 15 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Captan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 57 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Captan 5825 133062 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.13 0.13 0.1 19.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1995 Critical Effect Decreased pup body weight Kidney, Ureter, Bladder - other changes in urine composition, Blood - pigmented or nuceated red blood cells, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0024 0.0035 0.0023 3 mg/L (mgftg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 910 14.6 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/SWC EEC: 84.3 CAR HRL/SWC EEC: 1.35 Notes Reference Dose; Basis = NOEL 12.5 mg/kg-d; UF = 100 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 38(9), 24,1 973 Supplemental Data CACART; EPA; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Captan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 58 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 3,992,782 15 2,938 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 3 6 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 10.8 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 84.3 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 1.35 Fungicide (NTP) Value 862.2 2.8 7.01 E-09 5.1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades Sometimes/Reca citrant. However, hydrolysis half-life s 4.9 hrs - 1 8.8 hrs @ pH 7 and 5, respectively. ------- Chlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 59 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Chlorate 24376 14866683 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 5 1.4 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 Critical Effect Thyroid hypertrophy and mineralization Bone marrow hyperplasia; thyroid folicular hypertrophy and mineralization Blood - pigmented or nucleated red blood cells, Blood - changes in erythrocyte (RBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Not likely to be carcinogenic at doses that do not alter thyroid Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 10 HRL Ratio(s) NC HRL/DBP ICR 90% : 0.656 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data - NTP Abstract for TR-51 7; 2-year rat study for sodium chlorate Lowest Observed Adverse Effect Level; 1-year oral rat study fopr sodium chlorate; Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 60 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 1,713 #with Detects 1,490 % PWSs/Sites with detects 86.7 Mean value of Detects 172 Maximum value of Detects 2,234 Median value of Detects 120 90% of Detects 320 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 7,261,557 n PWSs/Sites/Sa mples 116 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 66 Number of States 16 % PWSs/Sites/Sam pies with detects 56.9 Units States States States Median of Detects 110 Non-cancer: 0.656 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 1997 2004 2004 Maximum of Detects 747 Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes For sodium chlorate Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.aspx Cancer: Agricultural defol ant or desiccant and in the production of CIO 2 (HSDB). Value 1,000,000 Units days L/kg unitless cm3/g atm-m3/mol mg/L Degradation Code Notes For sodium chlorate ------- Chloromethane (Methyl chloride) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 61 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Chloromethane (Methyl chloride 2605 74873 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.004 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Mild neurological effects in humans occupationally exposed to Chloromethane Cancer Data EPA Lifetime Cancer Risk, ICT* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.013 D 3 mg/L (mg/kg-d)-' (mg/kg-d)"1 1981 2001 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 28 2.69 Y/N Y/N mg/L ug/L ug/L 2006 developmental Teratogen Prevalence Magnitude , „ , 87 L' L HRL Ratio(s) NC HRL/NCOD R1 90%: 2.15 CAR HRL/NCOD R1 90%: 0.207 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CUT, 1981 Vol. 41,Suppl. 7, Vol. 71; 1999 CACART, RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Chloromethane (Methyl chloride) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 62 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NGOD Round 2 finished water NIRS finished water 20,246 23,478 248 528 1.22 2.25 0.01 0.00073 550 312 1.9 1.4 13 5 120 29 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Krasneretal., 2006 HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 3,959 Amount Released 1,539 1,733,197 n PWSs/Sites/Sa mples 11,984 12 356 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 247 1 8.99 Number of States 10 26 % PWSs/Sites/Sam pies with detects 2.1 8 0.007 Units States States States Minimum value of Detects 0.25 Non-cancer: 2.15 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 21 Year 2004 2004 Maximum value of Detects 46 0.04 0.1 0.58 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.7 ND 90% of Detects 2 Units for Mag data ug/L ug/L Cancer: 0.207 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185. Foaming agent; in organic synthes s (HSDB); naturally-occurring gas Value 15 14 0.91 8.82E-03 5320 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Clethodim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 63 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Clethodim 76719 110429624 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 0.01 1,360 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Increased liver weights increased liver enzymes and iver histopathology Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 6 Li HRL Ratio(s) NC HRL/SWC EEC: 9.21 Notes Reference Dose; Basis = NOEL 1 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Oral study in rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year -,C272,1991 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Clethodim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 64 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 670,721 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data: OPP Estimated Environmental Concentration Surface water chronic: 7.6 ug/L Ground water chronic: 0.49 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 9.21 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide; pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Cobalt CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 65 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Cobalt 18870 7440484 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.01 0.0014 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2004 2000 Critical Effect Blood-increased hemoglobin, polycythemia; respiratory-effects on lung function Heart Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, _ 4 8 NL' HRL Ratio(s) NCHRL/NIRS90%:6.67 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; 'multiple studies as cited in ATSDR, 1992; UF = 30; human study; RIVM; Basis LOAEL = 0.04 mg/kg-d Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Vol. 52; 1991; NB: Evaluated as a group; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cobalt CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 66 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 3 0.303 6.4 10.6 9.7 10.5 10.6 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 3,297 Amount Released 1,272 786,491 # PWSs/Sites sampled 782 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 23.7 Number of States 17 38 % PWSs/Sites with detects 0.007 Units States States States Minimum value of Detects Non-cancer: 6.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 684 Year 2004 2004 Maximum value of Detects 0.22 3.91 53.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for cobaltous chloride: Formerly in medicines; as germicide (HSDB); naturally-occurring Value 534,200 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for cobaltous chloride; BST = biodegrades sometimes/reca citrant ------- Cumene hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 67 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Cumene hydroperoxide 2927 80159 Attribute Scores Potency Severity 4 9 Prevalence Magnitude 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 32.7 382 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Mortality Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 76.4 Y/N Y/N ug/L ug/L 3-model Categorical Prediction L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issueXpage/year 19,205,1958; 7 week oral study in rats Supplemental Data Oral study in rats Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cumene hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 68 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 96 443,772 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 15 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (HSDB) Value 2.16 4.71 E-08 13,900 25 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation; PBT ------- Cylindrospermopsin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 69 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Cylindrospermopsin 81115 143545908 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00003 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg*g-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Increased kidney weight Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.21 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 5 10 L' Scores based on supplemental data HRL Ratio(s) c^notoxTsuryr00" *"** °" ""** NC HRL/CyanoHABs MAX: -0.0021 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis LOAEL 60 ug/kg-d; NOAEL 3 ug/kg-d. Humpage, A.R. and I.R. Falconer. 2003. Oral toxicity of the cyanobacterial toxin Cylindrospermopsin in male Swiss albino mice: Determination of no observed adverse effect level for deriving a drinking water guideline value. Environ. Toxicol. 18(2):94-103. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cylindrospermopsin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 70 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CyanoHABs - The Florida Experience UCMR 1 Meeting summary HRL Ratios (HRL/CyanoHABs MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects Not Available Not Available Units States States States Minimum value of Detects Non-cancer: -0.0021 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects -100 90 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: Notes 2000 Florida study Florida survey Cyanobacterial toxin Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dicrotophos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 71 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Dicrotophos 6098 141662 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00007 0.0001 0.0001 11 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Decreased plasma, RBC & brain ChE activity Decreased body weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification Suggestive evidence mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.49 Y/N Y/N ug/L ug/L Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 2.45 Notes Reference Dose; Basis = LOAEL 0.02 mg/kg-d; UF = 300. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont, Canada) Volume(issue)/page/year 6,196,1973 OPP; no quantif cation Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dicrotophos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 72 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 359,726 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 13 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year Maximum value of Detects 0 0 Surface water chronic: 0.2 ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects 0 0 Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA); 2002 2002 Ground water chronic: 0.005 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 2.45 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 366.2 -0.49 5.05E-11 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Dimethipin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 73 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Dimethipin 36818 55290647 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0218 0.02 0.02 0.02 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1999 Critical Effect Kidney, lungs, duodenum, liver, glandular stomach, heart, aortic artery & testes toxicity. Decreased body weight gain. ncreased absolute and relative liver weight Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 153 Y/N Y/N ug/L ug/L Prevalence Magnitude 8 5 Li HRL Ratio(s) NC HRL/GWC EEC: 1.55 Notes Reference Dose; Basis = NOEL 2.1 8 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethipin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 74 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 282,458 0 250 Units Ibsfyr Ibs/yr Ibs/yr Number of States 14 0 1 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 7.3 ug/L Ground water chronic: 99 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.55 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide; plant growth regulator (HSDB) Value 27.41 -0.17 2.30E-11 4,600 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation; PBT ------- Dimethoate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 75 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Dimethoate 2413 60515 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0022 0.0002 0.0002 0.002 3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2007 1988 1996 Critical Effect Brain cholinesterase inhibition Brain cholinesterase nhibition Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)"1 2006 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 15.4 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 7 Li L HRL Ratio(s) NC HRL/SWC EEC: 0.655 Notes Reference Dose; OPP RED Reference Dose; Basis NOEL 0.05 mg/kg-d; UF = 100. American Cyanamid Co., 1986a Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level - 52-week study in rat; BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year21,52,1964 Supplemental Data OPP UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dimethoate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 76 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! Amount Released 1,896,947 2,615 31,480 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 7,238 890 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 4 #with Detects 0 14 Number of States 44 2 4 % PWSs/Sites/Sam pies with detects 1.3 % PWSs/Sites/Sam pies with detects 0 1.57 Units States States States Minimum value of Detects Minimum value of Detects 0.055 Year 1997 2004 2004 Maximum value of Detects 0.022 Maximum value of Detects 0.21 Surface water chronic: 23.5 ug/L Non-cancer: 0.655 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.148 95% of Detects 90% of Detects 0.198 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.044 ug/L Cancer: Pesticide (NTP) Value 8 5.2-36 0.78 2.43E-10 23,800 36 Units weeks L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation ------- Disulfoton CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 77 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Disulfoton 6423 298044 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00013 0.00004 0.0001 0.00004 0.00006 0.0003 0.06 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2002 1986 2006 08/1995 1991 Critical Effect Plasma, RBC, brain & corneal ChE inhibition Brain and Coverings - other degenerative changes, Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification E mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0035 0.91 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 1 1 NL HRL Ratio(s) NCHRL/NAWQA90%: 1.1 Notes Reference Dose; Basis = NOAEL 0.013 mgrtsg-d; UF = 100. Reference Dose; Basis = LOAEL 0.04 mg/kg-d; UF = 1 ,000. Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue)/page/year35,101,1997 Supplemental Data, ITER Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Disulfoton CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 78 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 1,196,066 n PWSs/Sites/Sa mples 17 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 0.24 Number of States 33 % PWSs/Sites/Sam pies with detects 0 0 0.002 Units States States States Minimum value of Detects Non-cancer: 1.1 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 3.81 Year 1997 Maximum value of Detects Not Detected Not Detected 0.02 0.826 3.81 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA); 2002 2002 nsecticide (HSDB) Value 7-41 684-14,013 4.02 2.20E-06 16.3 17 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades Slowly ------- Diuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 79 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Diuron 6583 330541 Attribute Scores 3-model Categorical Prediction Potency Severity 6 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.002 0.003 0.002 1.75 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 Critical Effect Hemolytic anemia & compensatory hematopotesis (decreased erythrocyte count, hemoglobin level, etc). Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Liver - changes in liver weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases Cancer Data EPA Lifetime Cancer Risk, 104 EPA OPP Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0191 Known/Likely mg/L (mg/kg-d)-1 (mg/kg-d)-1 2003 2003 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 21 1.83 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 4 7 NL! HRL Ratio(s) NCHRL/UCMR90%: 10 CAR HRL/UCMR 90%: 0.871 Notes Reference Dose; du Pont, 1364a; Basis = LOAEL 1 .0 mg/kg-d; UF = 300. Reference Dose; Basis NOEL 0.625 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day study in rat; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year36,76,1990 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. EPA, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diuron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 80 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 298 1 0.34 2.1 2.1 2.1 2.1 2.1 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water PPMP ambient water PPMP finished water HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,552 Amount Released 4,370,448 10 798 n PWSs/Sites/Sa mples 270 319 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 117 13 7.00 Number of States 39 2 5 % PWSs/Sites/Sam pies with detects 0.4 37.5 5.8 0.0004 Units States States States Minimum value of Detects 0.058 Non-cancer: 10 Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 23.3 Year 1997 2004 2004 Maximum value of Detects 0.058 0.54 0.079 0.09 0.915 8.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects 0.319 0.079 Units ug/L ug/L ug/L Cancer: 0.871 Notes Pesticide Data Program (USDA); 2002 Herbicide (HSDB Value 224-879 2.68 5.8E-10 36.4 15 Units months L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes BST = biodegrades sometimes/recalcitrant ------- Equilenin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 81 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Equilenin 81750 517099 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 9 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) NC HRL/Kolpin MAX: 1.26 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Equilenin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 82 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 2.8 Units States States States Minimum value of Detects Non-cancer: 1.26 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.278 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.14 90% of Detects Units for Mag data ug/L Notes National Surfac Sci.&Technol e Water Reconnaissance; Kolpin, etal., 2002. Env. 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 3.93 1.52 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Equilin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 83 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Equilin 81748 474862 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 8 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) NC HRL/Kolpin MAX: 2.38 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Equilin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 84 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples ro Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 1.4 Units States States States Minimum value of Detects Non-cancer: 2.38 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.147 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.147 90% of Detects Units for Mag data ug/L Notes National Surfac Sci. & Technol e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 38 3.35 1.41 13 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Erythromycin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 85 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Erythromycin 75632 114078 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0007 66.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Inhibition of beneficial gastrointestinal bacteria Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4.9 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 HRL Ratio(s) NC HRL/NREC MAX: 2.88 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Da ly Dose (MRDD) UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Erythromycin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 86 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Focazio, etal., 2008 HRL Ratios (HRL/NREC MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 104 90 Amount Released n PWSs/Sites/Sa mples 22 0 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 21.5 0.0 Number of States % PWSs/Sites/Sam pies with detects Not detected Units States States States Minimum value of Detects Non-cancer: 2.88 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.7 Not detected Year Maximum value of Detects 0.3 0.1 Not detected Not detected Not detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 90% of Detects Units for Mag data ug/L Notes Drinking water monitoring; Focazio, etal., 2008. Sci.Tot. Env. 402(2-3), pp. 201-216. Cancer: Pharmaceutica , antibiotic Value 180 3.06 5.20E-29 6 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Estradiol (17-beta estradiol) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 87 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Estradiol (17-beta estradiol) 2130 50282 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormona response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 39 1 mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.35 0.0009 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude , 10 5 L HRL Ratio(s) NC HRL/Kolpin MAX: 1.75 CAR HRL/Kolpin MAX: 0.0045 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IARC, CACART, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Estradiol (17-beta estradiol) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 88 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 10.6 Units States States States Minimum value of Detects Not detected Non-cancer: 1.75 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected 0.0064 0.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 0.16 90% of Detects Not detected Units for Mag No(es data ug/L ug/L ug/L Cancer: 0.0045 Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci.&Techno ., 36(6), pp. 1202-1211. Pharmaceutical, hormone Value 38 4.01 6.40E-11 3.6 11 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Estriol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 89 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Estriol 75525 50271 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 10 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/Kolpin MAX: 6.86 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Estriol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 90 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 0.0 21.4 Units States States States Minimum value of Detects Not detected Not detected Non-cancer: 6.86 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected Not detected 0.051 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected Not detected 0.019 90% of Detects Not detected Not detected Units for Mag data ug/L ug/L ug/L Cancer: Notes Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. National Surfac Sci. & Techno . e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Pharmaceutica , hormone Value 38 2.45 1.33E-12 441 17 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Estrone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 91 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Estrone 2210 53167 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.35 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 9 3 Li HRL Ratio(s) NC HRL/Swartz MAX: 2.92 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Estrone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 92 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Boyd, etal.,2003 Snyder, 2008 Kolpin.etal., 2002 Swartz, etal.,2006 HRL Ratios (HRL/Swartz MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 7.1 Units States States States Minimum value of Detects Not detected Non-cancer: 2.92 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected 0.002 0.112 0.12 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 0.027 90% of Detects Not detected Units for Mag No(es data Finished Drinking Water; Boyd, etal, 2003. Sci. Tot. Env. 311(1-3): pp. 135-149. ug/L ug/L ug/L Cancer: Raw Drinking Water; Snyder, et al, 2008. Removal of Endocrine Disrupters and Pharmaceuticals during Water Treatment. In: Fate of Pharmaceuticals in the Environmental and in Water Treatment Systems. National Surfac Sci. & Technol e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Ambient Water (SW/GW); Swartz, et al., 2006. Env. Sci. & Technol. 40(16): pp. 4894-4902. Pharmaceutical, hormone Value 38 3.13 3.80E-10 30 13 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Ethinyl Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 93 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ethinyl Estradiol (17-alpha ethynyl estradiol) 2327 57636 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GGT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.337 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, etal., 1981 as cited in Maier and Hermann, 2001. Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethinyl Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 94 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 0.0 5.7 Units States States States Minimum value of Detects (ug/L) Not detected Not detected Non-cancer: 0.337 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects (ug/L) Not detected Not detected 0.273 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects (ug/L) Not detected Not detected 0.094 90% of Detects (ug/L) Not detected Not detected Units for Mag data ug/L ug/L ug/L Cancer: Notes Finished Drinking Water; Snyder, et al., 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al., 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Response to Comment on National Surface Water Reconnaissance Kolpin et al., 2002: Env. Sci. & Technol., 36(18), pp. 4007-4008. Pharmaceutical, hormone Value 60 3.67 7.94E-12 11.3 9 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Ethoprop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 95 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ethoprop 22682 13194484 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.0004 33 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Plasma ChE inhibition, Q1* 0.0281 (mg/kg-day)-1 - Likely. Behavioral - changes in motor activity (specific assay), Behavioral - muscle contraction or spasticity Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.12 0.0281 Likely mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.7 1.25 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, _ 7 3 NL' HRL Ratio(s) NC HRL/NAWQA 90%: 7.29 CAR HRL/NAWQA 90%: 13 Notes Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 1 ,693,2001 OPP RED and Ethoprop pesticide tolerances: 73 FR 53725, Spetember 17, 2008 CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethoprop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 96 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 1,010,807 0 77,786 n PWSs/Sites/Sa mples 84 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 1.18 Number of States 28 0 4 % PWSs/Sites/Sam pies with detects 0 0 0.002 Units States States States Minimum value of Detects Non-cancer: 7.29 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.95 Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected 0.011 0.096 0.8 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Cancer: 13 Notes Pesticide Pilot Mentoring Program (USGS/EPA); 2001 2001 nsecticide (HSDB) Value 75-133 70-120 3.59 1.70E-07 750 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes hydrolysis only: BST = biodegrades sometimes/recalcitrant ------- Ethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 97 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene glycol 4599 107211 Attribute Scores Potency Severity 3 9 Prevalence Magnitude 10 10 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2 2 2 0.8 0.05 600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 2007 2000 Critical Effect Kidney toxicity. Increased mortality, neutrophil count, kidney hemoglobin & hematocrit, chronic nephritis ncreased total malformations and incidence of extra rib 14 in developmental study Kidney Behavioral - fluid intake, Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 14,000 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen 3-model Categorical Prediction L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; DePass et al., 1986a; UF = 100; Rat; Basis NOAEL = 200 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Gaunt etal., 1974; UF = 1,000; Rat Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2 year oral study in rate; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year3,229,1965 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 98 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 576,990 10,076,483 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 31 49 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Antifreeze; cancelled pesticide; synthetic chemical used in textile manufacture (NTP) Value 1 -1.36 6.00E-08 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Ethylene Oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 99 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene Oxide 2635 75218 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 1.02 0.31 1 mg/L (mg/kg-d)-1 (mg/kg-d)-' 1994 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.113 Y/N Y/N ug/L ug/L Teratogen; Developmental Prevalence Magnitude 10 8 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HEAST CACART; RAIS; OEHHA; EPA; IARC UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylene Oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 100 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 4,761 374,110 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 4 38 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fumigant (NTP); gas Value 1.435 -0.3 1.48E-04 1,000,000 43 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes PBT; BS = biodegrades slowly ------- Ethylene thiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 101 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene thiourea 3836 96457 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0002 0.00008 0.00008 0.00008 0.004 1.34 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 2006 1993 Critical Effect Thyroid toxicity ncreased incidence of thyroid hyperplasia Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.006 0.06 0.045 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 1988 2001 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.003 1.4 0.06 Y/N Y/N mg/L W/L W/L 2006 Teratogen; Developmental Prevalence Magnitude 4 1 NLi HRL Ratio(s) NC HRL/GWC EEC: 6.67 CAR HRL/GWC EEC: 0.286 Notes Reference Dose Reference Dose; Basis LOAEL 0.25 mg/kg-d. Graham etal., 1975 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 8-week study in rat; JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/vear 21,324,1973 Supplemental Data OPP OPP EPA; RAIS; OEHHA; IARC; CACART UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ethylene thiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 102 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 5 299 Units Ibs/yr Ibs/yr Ibsfyr Number of States 1 4 Units States States States Year 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 0.1 ug/L Ground water chronic: 0.21 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 6.67 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.286 Pesticide (NTP) Accelerator; industrial intermediate (HSDB) Value 15 6.5 -0.66 3.40E-07 20,000 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly (at 30 C) ------- Fenamiphos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 103 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Fenamiphos 27401 22224926 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.00025 0.0001 0.00025 0.0008 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 2006 1997 Critical Effect Plasma ChE inhibition. Cholinesterase inhibit on Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification E mg/L (mg/kg-d)-1 (mg/kg-d)"1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0035 0.7 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 0.051 Notes Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100. Reference Dose; Basis = NOEL 0.025 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. OPP changed cancer classification from D to E. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fenamiphos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 104 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 726,675 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 14 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 Maximum value of Detects Not Detected Not Detected Surface water chronic: 13.7 ug/L Non-cancer: 0.051 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.47 ug/L Cancer: nsecticide (HSDB) Value 225.1 3.23 1.21E-09 329 12 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation; PBT ------- Formaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 105 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Formaldehyde 2119 50000 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.2 0.2 0.2 12.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 2006 1999 Critical Effect Reduced weight gain, histopathology in rats. Decreased absolute heart, liver, testes & kidney weights. Increased relative brain, testes weights. Gastro. Liver - other changes, Blood - changes in spleen Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification B1 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 1993 1995 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 7 1,400 Y/N Y/N ug/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/DBP ICR MED: 184 Notes Reference Dose Reference Dose; Basis = NOAEL 15 mg/kg-d; UF = 100. Til etal., 1989 Reference Dose Reference Dose Minimal Risk Level; Basis = NOAEL 15 mg/kg-d; ATSDR MRL-int = 0.3 mg/kg-d (Til etal., 1989). Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,339,1994 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART; EPA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Formaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 106 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR # PWSs/Sites sampled 227 #with Detects 126 % PWSs/Sites with detects 55.5 Minimum value of Detects 5 Maximum value of Detects 30.6 Median value of Detects 7.6 99% of Detects 29.7 Units for Mag data ug/L Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 326,298 26,992,234 Units Ibs/yr Ibs/yr Ibs/yr Number of States 31 46 Units States States States Non-cancer: 184 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Units for Mag data ug/L ug/L ug/L Notes Notes ug/L ug/L ug/L ug/L ug/L National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Cancer: Naturally-occurring fungicide (NTP); Disinfection by-Product; gas Value 1 0.35 3.38E-07 400,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- Germanium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 107 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Germanium 18876 7440564 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.318 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.744 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 10 Li HRL Ratio(s) NC HRL/NIRS 90% : 0.003 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POBS272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page;year 30,67,1991. EPA believes the RTECS LOAEL may be incorrectly cited (should be 3.18 not 0.318). Both values suggest listing germanium. Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Germanium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 108 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 4 0.40 2B 230 220 220 230 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.003 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for germanium diox de: Phosphors, transistors and diodes; electroplating (HSDB); naturally-occurr ng Value 4,470 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for germanium dioxide; BST = biodegrades sometimes/reca citrant ------- Halon 1011 (bromochloromethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 109 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Halon 1011 (bromochloromethane) 2613 74975 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased liver-to-body weight ratio. Cloudy swelling and vacuolization of hepatocytes. Prevalence Magnitude 5 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 7 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.5 70 Y/N Y/N mg/L ug/L ug/L 2006 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For care nogens, the concentration at the 1 0 "6 cancer risk was used. ------- Halon 1011 (bromochloromethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 110 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NGOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,881 22,974 65 106 0.5 0.461 0.05 0.0023 210 33.4 1 1 10 6 210 27.9 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Krasner, etal., 2006 HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1/2, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,238 ^Samples Amount Released n PWSs/Sites/Sa mples 7 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.165 % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 0.1 0.0 0.01 Minimum value of Detects Units States States States Minimum value of Detects Not detected Non-cancer: 7 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.45 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not detected 0.2 Median value of Detects 0.422 90% of Detects 0.45 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1 Not detected 99% of Detects Not detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Krasner, etal., 2006. Env. Sci. &Technol. 40 (23): pp. 7175-7185. Fire extinguishing fluid; chemical intermediate (HSDB) Value 15 days 23.7 1.41 0.00146 16,700 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- HCFC-22 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 111 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): HCFC-22 2654 75456 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 13.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1983 Critical Effect Brain and Coverings - other degenerative changes, Blood - changes in other cell count (unspecified), Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 31.5 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 10 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 48(8),69,1983 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- HCFC-22 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 112 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2,972 7,075,769 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 35 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Refrigerant; low-temperature solvent; fluorocarbon resins, especially tetrafluoroethylene polymers (HSDB); gas Value 15 35.04 1.08 4.07E-02 2,770 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Hexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 113 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Hexane 4858 110543 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.06 1,429 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 Critical Effect Decreased body weight gain Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 420 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 10 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis LOAEL = 570 mg/kg-d, UF = 10,000, oral rat study. Health and Environmental Effects Document for n-Hexane, ECAO-CIN-Q076, Environmental Criteria and Assessment Office, Final Draft, September 1989. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year 1(3), 67,1985 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 114 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 14,489 39,844,882 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 38 53 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Naturally-occurring; solvent (NTP) Value 149 3.9 1.8 9.5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- Hydrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 115 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Hydrazine 6460 302012 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.001 3 3 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.01 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 9 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; IARC; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 116 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 5 165,485 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 16 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; rocket propellant; oxygen/chlorine scavenger (HSDB) Value 14.3 -2.07 1.44E-08 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 117 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Mestranol 2581 72333 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL (for ethinyl estradiol) Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.00083 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanineaminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GOT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 94 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.688 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 . Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 118 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Mestranol 2581 72333 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL (for ethinyl estradiol) Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.00083 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanineaminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GOT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 94 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.688 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 . Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 119 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin.etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 4.3 Units States States States Minimum value of Detects Non-cancer: 0.688 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.407 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.017 90% of Detects Units for Mag data ug/L Notes Response to Comment on National Surface Water Reconnaissance Kolpin et al., 2002: Env. Sci. & Technol, 36(18), pp. 4007-4008. Cancer: Metabolite of ethinyl estradiol Value 60 4.68 Practically insoluble 9 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Methamidophos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 120 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 965,584 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 6.9 ug/L Ground water chronic: 3.8 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.304 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 3.848 -0.8 8.70E-10 1000000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Methanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 121 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Methanol 2508 67561 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 0.5 3.13 5,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect ncreased SAP & SGPT& liver weight, decreased brain weight Liver - other changes Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 10 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S. EPA, 1986; Basis = NOEL 500 mg(kg-d; UF = 1,000; Rat Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 200 day oral study in rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year - ,89,1994 Supplemental Data Rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,87,1984 UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 122 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 10,966,234 201,697,278 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 41 52 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; gasoline additive (HSDB); anti-freeze Value 1 -0.77 4.56E-06 1000000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- Methyl bromide (Bromomethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 123 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Methyl bromide (Bromomethane 2601 74839 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0014 0.001 0.0014 0.003 1 29.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 9/1992 1966 Critical Effect Epithelial hyperplasia in theforestomach Gastro Kidney, Ureter, Bladder - other changes in urine composition, Skin and Appendages - hair, Nutritional and Gross Metabolic - we ght loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1989 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.05 9.8 Y/N Y/N mg/L ug/L ug/L 2006 Developmental Prevalence Magnitude , „ 67 L HRL Ratio(s) NC HRL/NCOD R1 90%: 0.891 Notes Reference Dose Reference Dose; Basis = NOAEL 1 .4 mg/kg-day; UF = 1 ,000; Rat. Danse et al.r 1984 Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year28,109,1990 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl bromide (Bromomethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 124 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,198 23,328 155 175 0.77 0.75 0.07 0.09 43 38.1 1 1.6 11 8.1 34 27.2 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,317 Amount Released 32,803,943 200 533,748 # PWSs/Sites sampled 3 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.069 Number of States 29 3 17 % PWSs/Sites with detects 0.04 Units States States States Minimum value of Detects Non-cancer: 0.891 Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.5 Year 1997 2004 2004 Maximum value of Detects 0.1 0.5 0.5 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled fumigant (NTP); gas Value 20-26.7 9-22 1.19 7.34E-03 13,400 42 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes hydrolysis only; BS = biodegrades slowly ------- Methyl tert-butyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 125 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Methyl tert-butyl ether 11918 1634044 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 0.01 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 8/1996 1991 Critical Effect Hepatic: Decreased blood urea nitrogen levels. Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - changes in calcium Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0018 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 2,100 19.4 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 58 L' HRL Ratio(s) NC HRL/UCMR 90%: 58.3 CAR HRL/UCMR 90%: 0.539 Notes Reference Dose Reference Dose Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Basis NOAEL 100 mg/kg-d Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in rat; JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year 9(5), 525, 1990 Supplemental Data OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl tert-butyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 126 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,617 17 0.47 5 49 9.2 36 49 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,328 Amount Released 40,177 2,040,906 # PWSs/Sites sampled 424 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 9.8 Number of States 17 42 % PWSs/Sites with detects 0.01 Units States States States Minimum value of Detects Non-cancer: 58.3 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 2,300 Year 2004 2004 Maximum value of Detects 0.3 7.85 1,800 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.539 Notes Octane booster in gasoline; manufacture of isobutene; extraction solvent (HSDB) Value 15 6 0.94 5.87E-04 51,000 46 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Metolachlor CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 127 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor 35270 51218452 Attribute Scores Potency Severity 4 3 Prevalence Magnitude 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.15 0.1 0.15 25 1,150 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 1988 2006 Critical Effect Decreased body weight gain Decreased body weight gain Behavioral - food intake (animal), Nutrtional and Gross Metabolic - weight loss or decreased weight gain, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 700 Y/N Y/N mg/L ug/L ug/L 2006 3-model Categorical Prediction NL? HRL Ratio(s) NC HRL/NCOD R2 90%: 321 Notes Reference Dose; Basis NOAEL = 9.7 mg/kg-d; UF = 100. OPP RED. Reference Dose; Basis = NOEL 15 mg/kg-d; UF = 100. Ciba-Geigy, 1983 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989 Supplemental Data NNGADV Nippon Noyaku Gakka shi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989 Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 ~6 cancer risk was used. ------- Metolachlor CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 128 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,165 Amount Released 67,336,211 n PWSs/Sites/Sa mples 203 582 n PWSs/Sites/Sa mples 7,345 2,082 1,817 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 102 233 288 198 #with Detects 15 676 25.4 8.76 1.23 Number of States 48 % PWSs/Sites/Sam pies with detects 50.2 40 89.2 86.8 % PWSs/Sites/Sam pies with detects 0.2 32.5 0.0002 Units States States States Minimum value of Detects 0.01 0.005 Minimum value of Detects 0.05 0.00867 Non-cancer: 321 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 77.6 Year 1997 Maximum value of Detects 0.079 0.226 3.32 0.661 Maximum value of Detects 0.7 86 0.025 0.12 0.125 0.58 6.71 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 0.033 0.336 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 2002 Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 47;78 22-310 3.13 9.00E-09 530 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes aerobic;anaerobic; BSA = biodegrades slow with acclimaton ------- Metolachlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 129 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor ethanesulfonic acid (ESA) 79218 171118095 Attribute Scores Potency Severity 2 1 Prevalence Magnitude 6 6 Scores based on parent HEALTH EFFECTS DATA1 - See Metolachlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 21000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No biologically significant effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer >7,000 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : >3,210 (NAWQA data for metolachlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Metolachlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 130 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag No(es data Finished Water Occurrence Data - FOR METOLACHLOR PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water FOR METOLACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NCOD R290%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 83 318 n PWSs/Sites/Sa mples 7,345 2,082 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 19 198 #with Detects 15 676 Number of States % PWSs/Sites/Samp les with detects 22.9 51.9 % PWSs/Sites/Samp les with detects 0.2 32.5 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.05 0.00867 Non-cancer: >3,210 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 2.21 2.24 Maximum value of Detects 0.7 86 ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR ESA 2002 - FOR METOLACHLOR ESA Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.as px NCOD data for metolachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Metolachlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 131 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor oxani ic acid (OA) 79220 152019733 Attribute Scores Potency Severity 2 1 Prevalence Magnitude 6 6 Scores based on parent HEALTH EFFECTS DATA1 - See Metolachlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No biologically significant effects Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7,000 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 3,210 (NAWQA data for metolachlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR OA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Metolachlor OA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 132 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag No(es data Finished Water Occurrence Data - FOR METOLACHLOR PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water FOR METOLACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NCOD R290%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KQC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 138 404 n PWSs/Sites/Sa mples 7,345 2,082 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 14 152 #with Detects 15 676 Number of States % PWSs/Sites/Sam pies with detects 10.1 37.6 % PWSs/Sites/Sam pies with detects 0.2 32.47 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.05 0.00867 Non-cancer: 3,210 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 4.42 1.41 Maximum value of Detects 0.7 86 ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR OA 2002 - FOR METOLACHLOR OA Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants. aspx NCOD data for metolachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Microcystin-LR CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 133 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Microcystin-LR 76859 101043372 Attribute Scores 3-model Categorical Prediction Potency Severity 9 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.000003 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Liver effects Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.021 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 4 Scores based on supplemental data HRL Ratio(s) NC HRL/AWWARF Typical Range MAX: 0.21 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y., Y. Makita, S. Nagata et al. 1 999. No chronic oral toxicity of a low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female Balb/C mice. Environ. Toxicol. 14(1):45-55. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Microcystin-LR CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 134 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data US and Canadian drinking water (bloom area, source, finished water) US and Canadian drinking water (bloom area, source, finished water) HRL Ratios (HRL/AWWARF Typical Range MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 677 677 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 542 542 Number of States % PWSs/Sites/Sam pies with detects 80 80 Units States States States Minimum value of Detects 0.002 Non-cancer: 0.21 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.1 1,200 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: Notes Maximum of typical range of detects (AWWARF, Carmichael) Maximum and m numum of detects (AWWARF, Carmichael) Cyanobacterial toxin Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Molinate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 135 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Molinate 12912 2212671 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.002 0.002 13.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1988 Critical Effect Degeneration/demyelination in sciatic nerve and atrophy/reserve cell hyperplasia of muscle Reproductive toxicity. Alteration in sperm morphology, reduced number of viable fetuses/litter, increased number of resorptions/litter Endocrine - other changes, Blood - normocytic anemia, Nutritional and Gross Metabolic - body temperature decrease Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 1 8 L' HRL Ratio(s) NCHRL/UCMR90%: 2.46 Notes Reference Dose; Basis LOAEL = 0.3 mg/kg-d, UF = 300, 2-year rat study. A Determination of the Existence of a Common Mechanism of Toxicity and a Screening Level Cumulative Food Risk Assessment, December 2001. OPP issued RfD as part of health assessment not the RED; http://epa.gov/oppsrrd1/cumulative/thiocarb.pdf Reference Dose; Basis NOEL 0.2 mg/kg-d; UF = 100. Stauffer Chemical Co., 1981 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 43 week study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(1 0) , 1 04, 1 975 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Molinate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 136 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,621 1 0.03 5.7 5.7 5.7 5.7 5.7 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 3,669,398 115 2,089 n PWSs/Sites/Sa mples 120 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 1.68 Number of States 6 1 2 % PWSs/Sites/Sam pies with detects 0.3 0.001 Units States States States Minimum value of Detects Non-cancer: 2.46 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 200 Year 1997 2004 2004 Maximum value of Detects 0.004 0.0372 3.41 47.9 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units ug/L Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA) Herbicide (HSDB) Value 40-160 80-120 3.21 4.10E-06 970 19 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes BST = biodegrades sometimes/recalcitrant ------- Molybdenum CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 137 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Molybdenum 18825 7439987 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.005 0.005 0.03 0.5 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2006 Critical Effect increased uric acid levels Effects on repro & fetal development (decreased gestational weight ga n, prolonged estrus cycle, failure to breed). Renal failure, diuresis, proteinuria Liver - other changes, Kidney, Ureter, Bladder - other changes, Nutritional and Gross Metabolic - weight loss or decreased weight ga n Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.2 35 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen List Prevalence Magnitude 98 Li HRL Ratio(s) NCHRL/NIRS90%: 1.17 Notes Reference Dose Reference Dose; Koval'skiy et al.( 1961; oral study in humans; UF = 30; Basis LOAEL = 0.14 mg/kd- d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; UL; IOM No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 9 week oral study in rabbits; VCVN5 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989. Volume(issue)/page/year -, 317, 1989 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Molybdenum CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 138 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 77 7.79 6.1 180 10 30 110 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 1.17 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data for molybdenum trioxide: As steel alloy; chemical reagent (HSDB); naturally-occurring Value 1,066 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data for molybdenum trioxide; BST = biodegrades sometimes/reca citrant All use and env. fate data for molybdenum trioxide ------- Nitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 139 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Nitrobenzene 3998 98953 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2009 Critical Effect Increased reticulocytesand methemaglobinemia Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1990 1996 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 14 Y/N Y/N ug/L ug/L Teratogen List Prevalence Magnitude 1 10 NLi HRL Ratio(s) NCHRL/UCMRAM90%: 0.14 Notes Reference Dose Reference Dose; NTP, 1983; subchronic rat study; UF = 1,000; Basis BMDL = 1.8 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART, IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 140 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,064 2 0.065 21. 6 100 60.8 100 100 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data UCMR finished water HRL Ratios (HRL/UCMR AM 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 60 350,301 # PWSs/Sites sampled 338 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States 1 14 % PWSs/Sites with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: 0.14 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes Analyzed under UCMR 1 , List 1 , Assessment Monitoring with detection limit of 10 ug/L. National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data Not Detected Cancer: Notes Analyzed under UCMR 1, List 2, Screening Survey with detection limit of 0.5 ug/L. Solvent (NTP) Value 15 30.6-370 1.85 2.40E-05 1,800 31 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = biodegrades slowly ------- Nitroglycerin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 141 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Nitroglycerin 2252 55630 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.125 0.008 105 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cardiac - cardiomyopathy including infarction, Cardiac - EKG changes not diagnostic of specified effects, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.2 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.292 2 Y/N Y/N ug/L ug/L Teratogen 3-model Categorical Prediction L?-L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26 week oral study in rats; FATOAO Farmakologiya i Toksikologiya (Moscow), For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year 48,76,1985 Supplemental Data; RTECS LOAEL, acute human study Oral study in rats; YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year 13,3649,1985 EPA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitroglycerin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 142 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0.2 55,979 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 9 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pharmaceutical/medication; production of explosives; Rocket propellants; (HSDB) Value 1.62 9.87E-08 1,380 32 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- N-Methyl-2-pyrrolidone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 143 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): N-Methyl-2-pyrrolidone 9980 872504 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 120 3,914 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Decreased weight gain, neurobehavioral effects, sedative effects Endocrine - changes in spleen weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4,200 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 10 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Tolerable Daily Intake; Basis NOAEL = 169 mg/kg-d, UF = 300, 90-day rat study, WHO/UNEP CICAD TDI Study #35 No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientif c & Technical Information. Volume(issue)/page/year OTS0528073 Supplemental Data ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(ssue)/page/year 26,1581,1976 UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- N-Methyl-2-pyrrolidone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 144 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 17,972 6,311,503 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 13 42 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical industry solvent; solvent for pesticide appl cation for food packing materials (HSDB) Value -0.38 3.20E-09 1,000,000 42 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- N-Nitrosodiethylamine (NDEA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 145 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosodiethylamine (NDEA) 2243 55185 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.00002 150 36 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.0002 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 1 2 Li HRL Ratio(s) See also supplemental water data No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; OEHHA; IARC; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosodiethylamine (NDEA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 146 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 1,000 n PWSs/Sites/Sa mples 26 26 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 0 Number of States 0 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Not Detected Not Detected Non-cancer: Amount Range Gasoline and lubr Value 38 142.7 0.48 3.63E-06 106,000 53 Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected Not Detected 90% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx cant additive; antioxidant; stabilizer n plastics (HSDB); Disinfection by-Product Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS/BSA Notes BS = Biodegrades Slowly; BSA = Biodegrades Slowly with Acclimation ------- N-Nitrosodimethylamine (NDMA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 147 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosodimethylamine (NDMA) 2446 62759 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.000008 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect mmunological Includ ng Allergic - decrease in cellular immune response, Immunological Including Allergic - decrease in humoral mmune response, Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.00007 51 16 B2 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 1986 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.056 0.00069 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 2 L' L Scores based on supplemental data HRL Ratio(s) NC HRL/CAL DHS 90%: 0.329 CAR HRL/CAL DHS 90%: 0.004 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year 37,351 ,1992 Supplemental Data IRIS (Vol. 17, Suppl. 7; 1987) CACART; RAIS; EPA; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosodimethylamine (NDMA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 148 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 409 585 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 87 0 Number of States % PWSs/Sites/Sam pies with detects 21.3 0 Units States States States Minimum value of Detects 0.001 Not Detected Non-cancer: 0.329 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 440 Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.009 Not Detected 90% of Detects 0.17 Not Detected Units for Mag data ug/L ug/L Cancer: 0.004 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwaterfPages/Chemicalconta minants.aspx ndustrial solvent; antioxidant; formerly in the production of rocket fuel (HSDB); Disinfection by-Product Value 38 12 -0.57 1.82E-06 Soluble 52 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation @37°C ------- N-Nitroso-di-n-propylamine NDPA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 149 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitroso-di-n-propylamine (NDPA) 8798 621647 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0005 7 7 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.005 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude .,, „ 2 2 NL.-L, HRL Ratio(s) See also supplemental water data CAR HRL/STORET 90% : 0.00049 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS CACART; EPA; RAIS; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitroso-di-n-propylamine NDPA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 150 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (HRL/STORET 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 506 n PWSs/Sites/Sa mples 127 1,309 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 22 Number of States 0 2 % PWSs/Sites/Sam pies with detects 0 1.68 Units States States States Minimum value of Detects Not Detected 0.19 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected 20 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 10 90% of Detects Not Detected 10.24 Units ug/L ug/L Cancer: 0.00049 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Research chemical (HSDB); Disinfection by-Product? Value 38 130 1.36 5.38E-06 10,000 44 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation @37°C ------- N-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 151 of 214 Contaminant Substance Key: Contaminant ID (CASRN): N-Nitrosodiphenylamine 3193 86306 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 20.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1966 Critical Effect Corneal opacities, epithelial hyperplasia of the bladder and decreased weight gain Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude ,,, 2 1 NL HRL Ratio(s) NC HRL/CAL DHS 90% : 1 .84 See also supplemental water data CAR HRL/CA|_ DH£. g()% . Q Og32 Notes Reference Dose Reference Dose Reference Dose Reference Dose; NC1 1979; Basis LOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 17-week oral study in rabbit; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/paae/vear 10(4). 60.1 966 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0049 0.009 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 IRIS Cited by OEHHA Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 140 7.1 Y/N Y/N ug/L ug/L CACART; EPA; OEHHA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- N-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 152 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 14 n PWSs/Sites/Sa mples 133 #with Detects Units Ibs/yr Ibs/yr Ibsfyr #with Detects 1 % Samples with detects Number of States 0 2 % PWSs/Sites/Sam pies with detects 0.75 Minimum value of Detects Units States States States Minimum value of Detects 76.2 Non-cancer: 1.84 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 76.2 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 76.2 90% of Detects 76.2 Units for Mag data ug/L Cancer: 0.0932 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Rubber and polymer additive; chemical reagent (HSDB); DBP Value 6,154 3.13 1.21E-06 35 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- N-Nitrosopyrrolidine (NPYR) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 153 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosopyrrolidine (NPYR) 10160 930552 Attribute Scores Potency Severity 7 8 Prevalence Magnitude HEALTH EFFECTS DATA1 See also supplemental water data Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.002 2.1 2.1 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1986 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.02 Y/N Y/N ug/L ug/L 3-model Categorical Prediction HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS CACART; EPA; OEHHA; RAIS; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosopyrrolidine (NPYR) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 154 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 27 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States % PWSs/Sites/Sam pies with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units ug/L Notes Cancer: Research chemical (HSDB) Value 38 19 -0.19 4.89E-08 1,000,000 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation @37°C ------- Norethindrone (19-Norethisteron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 155 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Norethindrone (19-Norethisterone) 2525 68224 Attribute Scores 3-model Categorical Prediction Potency Severity 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0167 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect The norethindrone abel indicates that if the drug is taken during the first trimester of pregnancy that the riskfor hypospadia in male offspring doubles. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification NTP Carcinogen Classification Reasonably antic carcinogenic mg/L (mg/kg-d)-1 (mg/kg-d)-1 Dated to be Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.04 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 HRL Ratio(s) NC HRL/Kolpin MAX: 0.0459 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Daily Dose (MRDD) NTP 1 1th Report on Carcinogens; no quantificatio of dose-response CACART UMD, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Norethindrone (19-Norethisteron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 156 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, et al., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 12.8 Units States States States Minimum value of Detects Non-cancer: 0.0459 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.872 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.048 90% of Detects Units for Mag data ug/L Notes National Surface Water Reconnaissance; Kolpin, etal., 2002. Env. Sci.&Technol., 36(6), pp. 1202-1211. Cancer: Value 60 2.97 5.80E-10 7.04 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- n-Propylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 157 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): n-Propylbenzene 4328 103651 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2.5 6,040 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - changes in spleen Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5.83 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 1.21 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVQH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Qalogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. Volume(issue)/page/year -,167,1990; 24 week oral study in rat Supplemental Data Rats; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year 2,327,1964 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- n-Propylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 158 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,724 22,970 42 54 0.33 0.24 0.03 0.1 34 21 0.7 0.6 4.8 4 34 21 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released # PWSs/Sites sampled 53 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1.23 Number of States % PWSs/Sites with detects 0.004 Units States States States Minimum value of Detects Non-cancer: 1.21 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 47 Year Maximum value of Detects 0.024 5 47 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Manufacture of methylstyrene; text le dyeing; printing solvent; asphalt and naphtha constituent (HSDB) Value 15 495-955 3.69 1.05E-02 23.4 22 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- o-Toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 159 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): o-Toluidine 3768 95534 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 340 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Kidney, Ureter, Bladder - proteinuria, Blood - normocytic anemia, Nutritional and Gross Metabol c - weight loss or decreased weight ga n. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.24 0.18 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 2000 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 793 0.194 Y/N Y/N ug/L ug/L Teratogen list Prevalence Magnitude , „ , 7 5 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VINIT Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Vo ume(issue)/page Supplemental Data HEAST Vol. 77; 2000 IARC, RAIS, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 160 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 5 10,774 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 9 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Intermediate in the manufacture of dyes, rubber, Pharmaceuticals and pesticides (HSDB) Value 74.04 1.32 1.98E-06 16,600 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Oxirane, methyl- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 161 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Oxirane, methyl- 2661 75569 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 26 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect ncreased combined incidence of hyperkeratosis, hyperplasia and papillomas. Brain and Coverings - other degeneratve changes, Liver - other changes, Blood - other changes Cancer Data EPA Lifetime Cancer Risk, 10"* OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.15 0.24 0.24 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1990 1994 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 60.7 0.233 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) No water data Notes Reference Dose; Basis = BMDL „ 1 .4 mg/kg-d; UF = 1 000. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 45-day study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 46(7), 76,1 981 Supplemental Data CACART; RAIS; OEHHA; EPA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Oxirane, methyl- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 162 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 28,761 433,536 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 5 28 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (NTP) Value 2.324 0.03 6.98E-05 590,000 44 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes PBT; BS = biodegrades slow ------- Oxydemeton-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 163 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Oxydemeton-methyl 6458 301122 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00013 0.0025 10 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect Decreased erythrocyte & brain ChE Decreased body weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.91 Y/N Y/N ug/L ug/L male, female Prevalence Magnitude 95 Li HRL Ratio(s) NC HRL/SWC EEC: 1.01 Notes Reference Dose; Basis = NOAEL 0.013 mgfkg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 85JDAH "Organophosphorus Pesticides Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974 Volume(issue)/page/year -,197,1974 CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Oxydemeton-methyl CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 164 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 154,227 0 0 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 19 0 0 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Surface water chronic: 0.9 ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.006 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.01 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value -0.74 1.62E-13 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS =Biodegrades Slowly ------- Oxyfluorfen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 165 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Oxyfluorfen 34731 42874033 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect ncr. abs. liver weight; nonneoplastic lesions Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0732 C mg/L (mg/kg-d)-' (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 21 0.478 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 6 Li L HRL Ratio(s) NC HRL/SWC EEC: 3.0 CAR HRL/SWC EEC: 0.067 Notes Reference Dose Reference Dose; Basis = NOEL 0.3 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year 9,643,1991 EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Oxyfluorfen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 166 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 705,255 0 5 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 37 0 2 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Surface water chronic: 7.1 ug/L Non-cancer: 3.0 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.08 ug/L Cancer: 0.067 Pesticide; herbicide Value 46,800 4.73 8.23E-07 0.116 5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant; PBT ------- Perchlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 167 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Perchlorate 24310 14797730 Attribute Scores 3-model Categorical Prediction Potency Severity 6 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0007 6 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d ug/L mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 2000 Critical Effect Radioactive iodide uptake inhibition (RAIU) in the thyroid Decreased newborn TSH Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification See notes mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-lnterimHA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 15 4.9 Y/N Y/N ug/L ug/L ug/L Teratogen Prevalence Magnitude .,, „ 9 8 NL!'L! HRL Ratio(s) NCHRL/UCMR90%: 0.35 Notes Reference Dose Reference Dose; Basis NOEL 0.007mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Brechner et al. 2000 No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and species differences in thyroid function (IRIS). UMD Interim Health Advisory; EPA is revisiting the intermin hHealth Advisory for perchlorate. The HRL for the CCL differs from the Interim HA based on the RSC used in the health advisory (0.62) and the default RSC (0.2) used for the CCL process. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perchlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 168 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,554 147 4.14 4 420 6.5 14 59 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.35 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Smokeless rocket and jet propellant; explosives; analytical chemistry, etch ng and engraving agent (HSDB) Value 200,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes All use and env. fate data are for ammonium perchlorate. ------- Perfluorooctane sulfonic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 169 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Perfluorooctane sulfonic acid (PFOS) 12176 1763231 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL EPA/FR NOAEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.03 251 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced F2 Body Weight Decreased body weights, increased liver weights, lowered serum total cholesterol, lowered triiodothyronine (T3) concentration, and lowered estradiol levels Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-Provisional HA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.2 0.2 Y/N Y/N ug/L ug/L ug/L January 2008 Prevalence Magnitude , „ , 10 7 L' L HRL Ratio(s) NC HRL/MN MW MAX: 0.143 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level No Observed Adverse Effect Level in 2 generation reproductive study in rats. Supplemental Data - FR October 18, 2000 (Volume 65, Number 202)] Perfluorooctyl Sulfonates; Proposed Significant New Use Rule [Page 6231 9-62333] Supplemental Data - Seacat et al., 2002, Toxicol. Sci. 68, 249-264. EPA Provisional HA: http://www.epa.gOV/waterscience/criteria/d rinkinglpha-PFOA_PFOS.pdf Lowest Observed Adverse Effect Level Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). The HRL was calculated in a d fferent manner than EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to derive the provisional HA. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perfluorooctane sulfonic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 170 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Select New Jersey Water Systems Select Minnesota municipal wells Select Minnesota non-community wells Select Minnesota private wells Aggregate of above Minnesota wells HRL Ratios (HRL/MN MW MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 37 22 26 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 13 6 0 0 6 Number of States % PWSs/Sites/Sam pies with detects 57% 16.2% 0% 0% 7.1% Units States States States Range of Detects (ug/L) 0.0042-0.019 ND-1.4 ND ND ND-1.4 Non-cancer: 0.143 Amount Range 10-500K 0 Units Ibs/yr Ibs/yr Year 2002 2003 (EPA est.) Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Notes Targeted Sampl ng 2006 - Targeted study "Determination of Perfluorooctanoic Acid (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water Supply. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Cancer: Estimate of zero as phased out. Surface-active agents in aqueous media; chemical intermediate; in fire-fight ng applications, floor polish; metal plating baths; pest c de active ingred ent for ant bait traps. (HSDB) Value 100,000 370 Units length of time L/kg unitless cm3/g atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant ------- Perfluorooctanoic acid (PFOA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 171 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Perfluorooctanoic acid (PFOA) 6614 335671 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.46 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Increased maternal liver weight at term Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-Provisional HA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 1.1 Y/N Y/N ug/L ug/L ug/L January 2008 Prevalence Magnitude 10 6 Scores based on supplemental data HRL Ratio(s) NC HRL/MN MW MAX: 1.22 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (BMDL10), Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA: http://www.epa.goV/waterscience/criteria/d rinking/pha-PFOA_PFOS.pdf Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). This value differs from EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to derive the provisional HA. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perfluorooctanoic acid (PFOA) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 172 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data NJDEP - Jan 2007 Little Hocking, OH Municipal Wells (FW) Select Minnesota municipal wells Select Minnesota non-community wells Select Minnesota private wells Aggregate of above Minnesota wells HRL Ratios (HRL/MN MW MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 No data 37 22 26 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 18 6 0 1 7 Number of States % PWSs/Sites/Sam pies with detects 78 16.2% 0% 3.8% 8.2% Units States States States Range of Detects (ug/L) <0.004 - 0.039 1.5-7.2 ND-0.9 ND ND-0.67 ND-0.9 Non-cancer: 1.22 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Notes Targeted study ' Determination of Perfluorooctanoic Ac d (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water Supply. Emmett, et al., 2006. J. Occ. Env. Med. Little Hocking, OH; data from 2002-2005. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Cancer: Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire-fight ng applications, cosmetics, greases and lubricants, pa nts, polishes and adhesives (HSDB) Value 180 27,000 9.10E-02 1 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Permethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 173 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Permethrin 35815 52645531 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.25 0.05 0.05 0.2 0.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1999 Critical Effect Neurotox (aggression, abnormal/ decreased movement), increased body temperature. Q1* 0.0096 (mg/kg/day)-1. See CAR ncreased liver weight Neurol. Cancer Data EPA Lifetime Cancer Risk, 10"* OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0096 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,750 3.65 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 7 Li L HRL Ratio(s) NC HRL/SWC EEC: 1,944 CAR HRL/SWC EEC: 4.05 Notes Reference Dose; Basis = NOAEL 25 mg/kg-d; UF = 100. Reference Dose; Basis = NOEL 5 mg/kd-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level; ATSDR MRL-int. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Permethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 174 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 1,066,056 0 17,979 Units Ibsfyr Ibs/yr Ibs/yr Number of States 48 0 7 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 0.9 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1,944 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 4.05 nsecticide (HSDB) Value 178,000 6.5 1.87E-06 0.006 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF/BST Notes BF = biodegrades fast; BST = biodegrades sometimes/reca c trant ------- Profenofos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 175 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Profenofos 34318 41198087 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.0004 0.05 162 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Inhibition of plasma & RBC ChE activity Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Behavioral - somnolence (general depressed activity), Behavioral - tremor, Gastrointestinal - changes in structure or function of salivary glands Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N ug/L ug/L Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 3.5 Notes Reference Dose; Basis = NOEL 0.005 mg*g-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 12,781,1987 Supplemental Data TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 73,16,1984 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Profenofos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 176 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 879,776 0 255 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 14 0 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Surface water chronic: 0.1 ug/L Non-cancer: 3.5 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.03 ug/L Cancer: Pesticide, insecticide, acaricide (HSDB) Value 4.68 2.21 E-08 28 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant; PBT ------- Quinoline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 177 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Quinoline 3467 91225 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.001 3 B2 mg/L (mg/kg-d)-1 (mg/kg-d)"1 2001 2001 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.01 Y/N Y/N ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS IRIS Hirao et al., 1976; oral study in rats CACART, EPA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Quinoline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 178 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 62 28,629 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 8 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; pharmaceutical (anti-malarial); flavoring (HSDB) Value 1,837 2.03 1.67E-06 6,110 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- RDX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 179 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): RDX 5404 121824 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 0.003 0.03 40 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 6/1995 Critical Effect nflammation of the prostate. Cardiac - other changes, Blood - pigmented or nucleated red blood cells, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.03 0.11 c mg/L (mg/kg-d)-1 (mg/kg-d)-1 1988 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 21 0.3 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 5 5 Li HRL Ratio(s) NCHRL/STORET90%: 0.092 CARHRL/STORET90%: 0.0013 Notes Reference Dose Reference Dose; Basis NOEL 0.3 mg/kg-d. U.S. DOD, 1983 Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year AD-A092-531 Supplemental Data EPAHA EPA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- RDX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 180 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental water data STORE! HRL Ratios (HRL/STORET 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 23 Number of States % PWSs/Sites/Sam pies with detects 100 Units States States States Minimum value of Detects 15 Non-cancer: 0.092 Amount Range >500K - 1 M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 270 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 140 90% of Detects 229 Units ug/L Cancer: 0.0013 Notes High explosive Value 195.4 0.87 6.30E-08 59.7 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- sec-Butyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 181 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): sec-Butylbenzene 5904 135988 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4.42 2,240 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -alteration of classical conditioning Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 10.3 Y/N Y/N ug/L ug/L Prevalence Magnitude 3 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 1.03 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 24-week oral rat study; VCVGH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated hydrocarbons) Bandman A.L. etal., Chimia, 1990. Volume(issueXpage/year -,179,1990 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- sec-Butyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 182 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,343 22,974 28 34 0.227 0.148 0.03 0.1 19.8 22 0.7 0.6 10 4.6 19.8 22 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released # PWSs/Sites sampled 25 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.58 Number of States % PWSs/Sites with detects 0.005 Units States States States Minimum value of Detects Non-cancer: 1.03 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 11 Year Maximum value of Detects 0.39 2.81 11 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent for coating compositions, organic synthesis, plasticizer, and surface active agents (HSDB) Value 15 7,200 4.57 1.80E-02 17.6 15 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Strontium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 183 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Strontium 18848 7440246 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 0.6 0.6 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2006 2004 Critical Effect Rachitic bone Musculo-skeletal effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 20 4,200 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 10 10 Li HRL Ratio(s) NCHRL/NIRS90%:3.88 Notes Reference Dose Reference Dose; Storey, 1961 ; Marie et al., 1985; Skoryna, 1981; UF = 300; Rat; Basis NOAEL = 190 mg/kg-d Reference Dose Reference Dose; IRIS Minimal Risk Level; UF = 30; MRL-Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Strontium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 184 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 980 99.1 1.5 43,550 178 1,080 7,340 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 3.88 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for strontium carbonate: In pyrotechnics; steel production; catalyst; lead scavenger (HSDB); naturally-occurring Value 11 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for strontium carbonate; BST = biodegrades sometimes/recalcitrant ------- Tebuconazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 185 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Tebuconazole 69191 107534963 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.029 0.03 1,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2008 1994 Critical Effect Decreased body weights, absolute brain weights, brain measurements and motor activity in offspring Behavioral - food intake (animal) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 2008 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 96 L' L HRL Ratio(s) NC HRL/GWC EEC: 9.09 Notes Reference Dose; Basis = LOAEL 8.8 mg/kg-d; UF = 300. Federal Register: May 14, 2008 (Volume 74, Number 94), pp 27748-27756. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Oral study- rabbit; NTIS Nationa Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0545183 OPP; 73 FR No. 94, pp 27748-27756. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tebuconazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 186 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 478,568 Units Ibs/yr Ibs/yr Ibs/yr Number of States 16 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 14 ug/L Ground water chronic: 23.1 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 9.09 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Fungicide (HSDB) Value 3.7 1.45E-10 36 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Tebufenozide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 187 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Tebufenozide 69514 112410238 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.018 0.02 8.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 2003 Critical Effect Growth retardation, alterations in hematology parameters, changes in organ weights, and histopathological lesions in the bone, spleen and liver Effect on erythrocytes, periferal hemolytic anaemia. Gross and histopathologica lesions in the spleen (congestion, pigment, and extra-medullary haematopoiesis) Blood - normocytic anemia, Blood - thrombocytopenia Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 126 Y/N Y/N ug/L ug/L Prevalence Magnitude 9 5 Li HRL Ratio(s) NC HRL/SWC EEC: 8.4 Notes Reference Dose; Basis NOAEL = 1 .8 mg/kg-d, UF = 100. Federal Register 64 FR, No. 203, pp 56690-56697, October 21, 1999. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year study in dog; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 64, 16851, 1999 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tebufenozide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 188 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 104,413 Units Ibsfyr Ibs/yr Ibs/yr Number of States 17 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 15 ug/L Ground water chronic: 1.19ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.4 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 4.25 1.26E-08 0.83 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Tellurium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 189 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Tellurium 23035 13494809 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 25 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Maternal toxicity Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 175 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 49 Li HRL Ratio(s) NCHRL/NIRS 90%: 0.673 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; No Observed Effect Leve ; Johnson et al., 1988 Lowest Observed Adverse Effect Level Supplemental Data Mouse; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of Internatonal Projects, GKNT, 1982 Volume(issue)/page/year - ,107,1982 UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tellurium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 190 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 4 0.4 15 370 22 260 360 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.673 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for sodium tellurite: Bacteriology, medicine (HSDB); naturally-occurring Value Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assume persistent; All use and env. fate data are for sodium tellurite; BST = biodegrades sometimes/recalcitrant ------- Terbufos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 191 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Terbufos 22585 13071799 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.00005 0.000025 0.0002 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 1989 Critical Effect Plasma ChE inhibition Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 1988 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.002 0.35 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQA 90% : 1.67 Notes Reference Dose; Basis = NOAEL 0.005 mgrtsg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Terbufos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 192 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T,,2, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 6,515,603 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 61 915 22 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 #with Detects 0 11 0.31 Number of States 37 % PWSs/Sites/Sam pies with detects 0 0 % PWSs/Sites/Sam pies with detects 0 1.2 0.0021 Units States States States Minimum value of Detects Minimum value of Detects 0.1 Non-cancer: 1.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.56 Year 1997 Maximum value of Detects Not Detected Not Detected Maximum value of Detects 3.2 0.017 0.21 0.56 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.185 95% of Detects Not Detected Not Detected 90% of Detects 0.202 Notes ug/L ug/L Units for Mag data ug/L ug/L Cancer: Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx nsecticide (HSDB) Value 38 500-5,000 4.48 2.40E-05 5.07 14 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation ------- Terbufos sulfone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 193 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Terbufos sulfone 37071 5607016 Attribute Scores Potency Severity 7 3 Prevalence Magnitude 1 1 Scores based on parent Scores based on parent HEALTH EFFECTS DATA1 - See parent Terbufos Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma ChE inhibition Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) NC HRL/NAWQA 90% : 1 .67 (NAWQA data and HRL for parent terbufos) Notes Reference Dose - FOR PARENT TERBUFOS Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level Based on data for parent terbufos 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Terbufos sulfone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 194 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Finished Water Occurrence Data FOR TERBUFOS - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 0 0 Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data FOR TERBUFOS - PARENT N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data FOR TERBUFOS - PARENT CAL DHS STORE! PPMP finished water PPMP ambient water HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released n PWSs/Sites/Sa mples 61 915 22 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 11 2 0 0.31 Number of States % PWSs/Sites/Sam pies with detects 0 1.2 0.9 0 0.0021 Units States States States Minimum value of Detects 0.1 Non-cancer: 1.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.56 Year Maximum value of Detects 3.2 0.016 0.017 0.21 0.56 Units for Mag data ug/L mg/L mg/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.185 90% of Detects 0.202 Units for Mag No(es data ug/L ug/L ug/L ug/L Cancer: Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O- ANALOGUE SULFONE Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O- ANALOGUE SULFONE NAWQA data and HRL for Parent Terbufos Pesticide degradate Value 38 2.21 E-08 21 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with ace mation ------- Thiodicarb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 195 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Thiodicarb 38116 59669260 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 2000 Critical Effect Extramedulary hematapoesis and decreased red blood cell cholinesterase activity Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0188 B2 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 1.86 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 6 L' L HRL Ratio(s) NC HRL/SWC EEC: 8.1 CAR HRL/SWC EEC: 0.07 Notes Reference Dose; Basis NOEL = 3.3 mg/kg-d (males) and 4.5 mg/kg-d (females); UF = 100; chronic rat study. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiodicarb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 196 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 821,267 0.05 1,430 Units Ibsfyr Ibs/yr Ibs/yr Number of States 27 1 3 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 26 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.1 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.07 nsecticide (HSDB) Value 1.7 9.33E-07 35 36 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Thiophanate-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 197 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Thiophanate-methyl 27753 23564058 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.08 0.08 0.08 0.08 1.2 2,270 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2004 1986 1998 Critical Effect Thyroid and liver effects and decreased body weight Decreased body weight, decreased spermatogenesis and histological evidence of hyperthyroidism Endocrine - evidence of thyroid hypofunction, Endocrine - changes in thyroid weight, Nutritional and Gross Metabolic - weight loss or decreased weight gain Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation), Behavioral - somno ence (general depressed activity), Behavioral - convulsions or effect on seizure threshold Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0116 C mg/L (mgftg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 560 3.02 Y/N Y/N ug/L ug/L Female & male reproductive toxicity Prevalence Magnitude , „ , 10 6 Li L HRL Ratio(s) NC HRL/SWC EEC: 45.9 CAR HRL/SWC EEC: 0.248 Notes Reference Dose; Basis NOEL = 8 mg/kg-d; UF = 100; chronic dog study. Reference Dose; Basis = NOEL 8 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 67,14944,2002 Supplemental Data TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 23,606,1972 OPP EPA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiophanate-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 198 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 453,792 0 92 Units Ibsfyr Ibs/yr Ibs/yr Number of States 40 0 3 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 12.2 ug/L Ground water chronic: 3.03 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 45.9 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.248 Fungicide (HSDB) Value 14.32 1.4 2.94E-13 438.9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Toluene diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 199 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Toluene diisocyanate 29421 26471625 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD501 CTDJPN Lowest Oral LD501 RTECS Lowest Oral LD501 Value 30 85.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Burns throat immediately. Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.039 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 0.9 Y/N Y/N ug/L ug/L Prevalence Magnitude , 10 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-251,1986 Supplemental Data Applies to m ixture of 2,4- and 2,6- isomers. CACART; IARC; OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Toluene diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 200 of 214 OCCURRENCE DATA # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 1 129,143 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 31 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M - 1 B >500M - 1 B Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n plastics manufacture (NTP) Value 9,114 3.74 1.11E-05 37.57 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Tribufos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 201 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Tribufos 2814 78488 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.00003 0.00003 4.08 77 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Plasma ChE inhibition Gastrointestinal - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - peptidases Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N ug/L ug/L Prevalence Magnitude 98 Li HRL Ratio(s) NC HRL/SWC EEC: 3.89 Notes Reference Dose; Basis = NOAEL 0.1 mg/kg-d; UF = 100. Reference Dose; Basis NOAEL 0.1 mg/kg-d; Abou-Donia etal., 1979 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 43 week study in rodent; FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year 38,96,1975 Supplemental Data 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,1188,1986 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tribufos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 202 of 214 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 4,918,265 4 7 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 16 1 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Surface water chronic 1.8ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 3.89 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide; cotton defoliant (HSDB) Value 1,888 5.7 2.94E-07 2.3 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes BF = biodegrades fast ------- Triethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 203 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Triethylamine 5379 121448 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1 460 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Brain and Coverings - other degenerative changes Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2.33 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 9 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-week oral rat study; WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Du ixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987 Volume(issue)/page/year 4,45,1990 Supplemental Data AMIHBCAMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(ssue)/page/year 4,119,1951 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Triethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 204 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 12,000 1,167,219 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 14 35 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; stabilizer; in herbicides/pest c des; in consumer products; food addit ve; photographic chemical; in carpet c eaners (HSDB) Value 107.2 1.45 1.49E-04 73,700 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Triphenyltin hydroxide (TPTH) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 205 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Triphenyltin hydroxide (TPTH) 2738 76879 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0003 0.0005 0.15 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1970 Critical Effect Decreased white blood cells Blood - changes in other cell count (unspecified), Blood - changes in leukocyte (WBC) count Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 18.3 B2 mg/L (mg/kg-d)-' (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 2.1 0.0019 Y/N Y/N ug/L ug/L Teratogen; Developmental Prevalence Magnitude 10 6 HRL Ratio(s) NC HRL/SWC EEC: 0.33 CAR HRL/SWC EEC: 0.0003 Notes Reference Dose; OPP RED Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in guinea pig; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year4,35,1966 Supplemental Data EPA; CACART UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Triphenyltin hydroxide (TPTH) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 206 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 660,971 0 0 Units Ibsfyr Ibs/yr Ibs/yr Number of States 26 0 0 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic 6.4 ug/L Ground water chronic 0 ug/L Notes HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.33 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.0003 Pesticide (NTP) Value 2,000 3.53 4.26E-07 0.4 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Urethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 207 of 214 Contaminant Substance Key: Contaminant ID (CASRN): Urethane 2189 51796 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.9 78 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 Critical Effect Decreased survival Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in leukocyte (WBC) count Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 1 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 6.3 0.035 Y/N Y/N ug/L ug/L Developmental Teratogen Prevalence Magnitude , 7 6 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Food and Chemical Toxicology 43 (2005) 1-19 Lowest Observed Adverse Effect Level; 1 3 week oral study in rats; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NIH-96- 3937 Supplemental Data Vol. 7, Suppl. 7; 1987 IARC; CACART; OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Urethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 208 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 96,050 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 0 7 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Paint ingredient (NTP) Value -0.15 6.40E-08 480,000 40 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Vanadium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 209 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Vanadium 18882 7440622 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.007 0.003 1.8 960 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2001 Critical Effect Minor renal effects (altered renal function as indicated by increased plasma urea, and mild histological changes). Kidney lesions and increases in plasma urea and uric acid Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 8 Li L HRL Ratio(s) NCHRL/NIRS90%:0.913 Notes Reference Dose Reference Dose Reference Dose Reference Dose; HEAST Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; IOM 2001 Dietary Reference ntakes No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; Domestic mammal Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vanadium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 210 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 146 14.76 3.1 70.4 7.27 23 45 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.913 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for vanadium pentoxide: Chemical intermediate; catalyst; (HSDB); naturally-occurring Value 8,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for vanad um pentoxide; BST = biodegrades sometimes/recalcitrant ------- Vinclozolin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 211 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Vinclozolin 35005 50471448 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.012 0.025 0.025 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1995 Critical Effect Histopathological les ons in the lungs, iver, ovaries & eyes. Q1 * 0.0638 (mg/kg-day)-1 .Group C. See CAR Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0638 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 84 0.549 Y/N Y/N ug/L ug/L Developmental Prevalence Magnitude , „ , 10 5 L' L HRL Ratio(s) NC HRL/SWC EEC: 8.94 CAR HRL/SWC EEC: 0.058 Notes Reference Dose; Basis = NOAEL 1 .2 mg/kg-d; UF = 1 00. Reference Dose; Basis = NOEL 2.5 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vinclozolin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 212 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 121,959 0 0 Units Ibsfyr Ibs/yr Ibs/yr Number of States 26 0 0 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 9.4 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.94 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.058 Fungicide (HSDB) Value 289 3.1 1.33E-08 2.6 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant ------- Ziram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 213 of 214 Contaminant: Substance Key: Contaminant ID (CASRN): Ziram 5947 137304 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.016 0.003 1.6 1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Decreased body weight gain Decreased body weight Gastrointestinal - hypermotility, diarrhea Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0611 Suggestive (not quantified) 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 112 0.57 Y/N Y/N ug/L ug/L Prevalence Magnitude , 10 7 L HRL Ratio(s) NC HRL/SWC EEC: 56.6 CAR HRL/SWC EEC: 0.288 Notes Reference Dose; Basis = NOAEL 1 .6 mg/kg-d; UF = 1 00. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake; Group ADI for Ferbam and Ziram Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level OPP Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 17,3155,1992 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ziram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 214 of 214 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 1,992,552 Units Ibsfyr Ibs/yr Ibs/yr Number of States 29 Units States States States Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Surface water chronic: 1 .98 ug/L Non-cancer: 56.6 Amount Range >500K - 1 M >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 Ground water chronic: 0.03 ug/L Cancer: 0.288 Synthetic rubber chemical (NTP); fungicide Value 6.20E-10 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- |