vvEPA United States Environmental Protection Agency Contaminant Information Sheets for the PCCL Chemicals Considered for CCL 3 ------- Office of Water (4607M) EPA815-R-09-014 August 2009 www.epa.gov/safewater ------- EPA815-R-09-014 Final CCL 3 Chemicals August 2009 EPA OGWDW Contaminant Information Sheets Page 1 of 1124 Contaminant Information Sheets for the PCCL Chemicals Considered for CCL 3 This File contains Contaminant Information Sheets for 561 chemical contaminants on the Preliminary Contaminant Candidate List (PCCL 3). These sheets summarize information about the chemicals that were considered during the analysis for the development of the final third Contaminant Candidate List (CCL 3). The sheets are in alphabetical order. The first 106 Information Sheets are for the chemicals on the final CCL 3. (Note: there are 104 chemical entries listed in the Federal Register Notice for the final CCL 3; cyanotoxins are listed as a group. In this file, there are information sheets on three individual cyanotoxins that were evaluated in the CCL 3 process (Anatoxin-a, Cylindrospermopsin, and Microcystin-LR)). Following the CCL 3 chemicals, the Information Sheets for the remaining 455 chemicals on the PCCL are presented in alphabetical order. Each information sheet is two pages in length. There is an index/bookmark in this PDF file that can be used to negotiate the file. The bookmarks are hyperlinked. You can find the contaminant name in the bookmark list, click on it, and the hyperlink will take you to that file. ------- EPA815-R-09-014 Final CCL 3 Chemicals August 2009 EPAOGWDW Contaminant Information Sheets Page 2 of 1124 This page intentionally left blank for double-sided printing ------- 1,1,1,2-Tetrachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 3 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1,1,1 ,2-Tetrachloroethane 9105 630206 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.03 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 Critical Effect Mineralization of the kidneys in males, hepatic clear cell change in females Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.1 0.026 C 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1989 1989 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1 210 1 Y/N Y/N mg/L ug/L ug/L 2006 3-model Categorical Prediction [_•? HRL Ratio(s) NC HRL/NCOD R1 90%: 67.7 CAR HRL/NCOD R1 90%: 0.323 Notes Reference Dose Reference Dose; Basis LOAEL = 89.3 mg/kg-d (NTP 1983) Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,1,1,2-Tetrachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 4 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,956 24,127 31 51 0.18 0.21 0.06 0.2 9.2 18 0.59 0.5 3.1 1.55 9.2 18 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released 36 12,088 # PWSs/Sites sampled 4 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.09 Number of States 2 7 % PWSs/Sites with detects 0.011 Units States States States Minimum value of Detects Non-cancer: 67.7 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.0644 Year 2004 2004 Maximum value of Detects 0.0275 0.0644 0.0644 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.323 Notes Chemical intermed ate (NTP) Value 60 93-399 2.66 2.70E-03 1,100 22 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- 1,1-Dichloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 5 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1,1-Dichloroethane 2647 75343 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Decreased body weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0057 C mg/L (mg/kg-d)-1 (mg/kg-d)-1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 1,400 6.14 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 77 Li HRL Ratio(s) NC HRL/NCOD R1 90%: 250 CAR HRL/NCOD R1 90%: 1.1 Notes Reference Dose Reference Dose Reference Dose Reference Dose; basis NOAEL 71 4 mg/kg-d, UF = 3,000; Muralidhara, et al, 2001 . Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,1-Dichloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 6 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,483 24,808 233 184 1.14 0.74 0.01 0.0013 500 159 1.2 1 5.6 3.8 27 25 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,350 Amount Released 63 17,368 # PWSs/Sites sampled 135 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3.103 Number of States 3 5 % PWSs/Sites with detects 0.008 Units States States States Minimum value of Detects Non-cancer: 250 Amount Range >1M-10M >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 39 Year 2004 2004 Maximum value of Detects 0.05 0.316 5.6 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 1.1 Notes Solvent (NTP) Value 38 30 1.79 5.62E-03 5040 46 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- 1,2,3-Trichloropropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 7 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1 ,2,3-Trichloropropane 3817 96184 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.006 0.006 0.006 0.06 5.71 22.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 1992 1987 Critical Effect Alterations in clinical chemistry & reduction in RBC mass Hepatic Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 7 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.2 42 0.005 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 3 6 Li HRL Ratio(s) NC HRL/NCOD R2 90%: 2.1 CAR HRL/NCOD R2 90% : 0.00025 Notes Reference Dose Reference Dose; NTP, 1983 ; rats; UF = 1,000; Basis NOAEL = 8 mg/kg-d Reference Dose; F' 89 Reference Dose Minimal Risk Level; Int-MRL; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; ITER NOAEL Lowest Observed Adverse Effect Level; 1 7 week oral study in rats; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP- TR-384,1993 Supplemental Data HEAST CACART, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2,3-Trichloropropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 8 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 17,392 24,088 44 19 0.25 0.079 0.1 0.03 112 3,000 0.92 0.5 6 20 112 3,000 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total 4,309 Amount Released 282 9,053 43 Units Ibs/yr Ibs/yr Ibs/yr 1.0 Number of States 1 2 0.05 Units States States States 2.92 Year 2004 2004 0.4 0.97 2.92 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data Nominated data from NJDEP HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler NJ study: Detected in excess of health-based drinking water guidance value in 30 of 2,640 private wells and 1 1 of approximately 260 community water systems between 1999 and 2004 in NJ SOC Waiver Program sampling. Non-cancer: 2.1 Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.00025 Notes Paint ingredient (NTP) Value 38 77-95 2.27 3.43E-04 1,750 25 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- 1,3-Butadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 9 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1,3-Butadiene 4578 106990 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 10 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3.4 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)-' 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.0103 Y/N Y/N ug/L ug/L Teratogen List 3-model Categorical Prediction L HRL Ratio(s) No Water Data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Vol.71; 1999 EPA, IARC, CACART, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Butadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 10 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 493 1,964,956 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 8 34 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber chemical (NTP) Value 7-28 288 1.99 7.40E-02 735 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- 1,3-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 11 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1,3-Dinitrobenzene 4045 99650 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.0001 0.0001 0.0005 1.73 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 1995 Critical Effect Increased spleen weight Hemato. Endocrine - changes in spleen weight, Blood - methemoglobinemia-carboxyhemoglobin Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.005 0.7 Y/N Y/N mg/L ug/L ug/L 2006 male Prevalence Magnitude 1 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Cody etal., 1981; Rats; UF = 3,000; Basis NOAEL = 0.4 mg/kg-d Reference Dose Reference Dose; IRIS Minimal Risk Level; Int-MRL; UF = 1 ,000 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90 day oral study in rats; TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year 30,200,1996 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,3-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 12 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2 528,962 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 1 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (HSDB) Value 38 150 1.49 4.90E-08 533 37 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- 1,4-Dioxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 13 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1,4-Dioxane 5539 123911 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.3 0.011 0.027 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 1999 1987 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 700 3 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 9 8 L HRL Ratio(s) NC HRL/CAL DHS 90%: 92.1 CAR HRL/CAL DHS 90%: 0.395 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; ATSDR MRL-int = 0.6 mg/kg-d Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; IARC; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,4-Dioxane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 14 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental water data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 89,521 821,067 n PWSs/Sites/Sa mples 869 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 89 Number of States 7 22 % PWSs/Sites/Sam pies with detects 10.2 Units States States States Minimum value of Detects 0.001 Non-cancer: 92.1 Amount Range >1M-10M >1M-10M Solvent (NTP); so Value 1 -0.27 4.80E-06 1,000,000 Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects 46.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 2.1 90% of Detects 7.6 Units ug/L Cancer: 0.395 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx vent stabilizer Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = biodegrades slowly ------- 17 alpha-Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 15 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 17 alpha-Estradio 81747 57910 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 9 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/Kolpin MAX: 4.7 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 17 alpha-Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 16 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, et al., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 5.7 Units States States States Minimum value of Detects Non-cancer: 4.7 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.074 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.03 90% of Detects Units for Mag data ug/L Notes National Surface Water Reconnaissance Kolpin, D.W., et al., 2002. Env. Sci. STechnol., 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 38 3.94 3.9 11 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- 1-Butanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 17 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Butanol 2563 71363 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Hypoactivity, ataxia Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 700 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 10 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S. EPA, 1986; Basis NOAEL = 125 mg/kg-d, UF = 1,000; oral study in rats. Reference Dose Reference Dose; IRIS Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30 day oral study in rats; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 135,3122,2002 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1-Butanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 18 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 22,011 17,648,846 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 20 44 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Paint solvent; chemical intermediate; food additive (HSDB) Value 2.443 0.88 8.82E-06 63200 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- 2-Methoxyethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 19 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Methoxyethanol 4803 109864 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 Units mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reproductive effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 21 Y/N Y/N ug/L ug/L Teratogen / developmental, male Prevalence Magnitude 9 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Unpublished NTP study - Gulati, et al, 1990. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD / CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Methoxyethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 20 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 14,390 153,774 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 3 16 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Consumer products; synthetic Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin Lot on (NTP) Value 1 -0.77 3.30E-07 1000000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with acclimat on ------- 2-Propen-1-ol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 21 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 2-Propen-1-ol 4596 107186 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.005 2.5 52 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Impaired renal function & increased relative liver, spleen & kidney weights Liver - liver function tests impaired, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Metabolism (Intermediary) - Plasma proteins not involvinq coaqulation Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 8 8 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Carpanini et al., 1978; Rat; UF = 1,000; Basis NOAEL = 4.8 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; Rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,121,1994 Supplemental Data Rabbit; NTIS National Technical Information Serv ce. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0571508 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-Propen-1-ol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 22 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 10,971 604,872 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 4 13 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Manufacture of flavorings, perfumes; chemical intermediate (HSDB) Value 1.325 0.17 5.00E-06 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- 3-Hydroxycarbofuran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 23 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 3-Hydroxycarbofuran 25541 16655826 Attribute Scores 3-model Categorical Prediction Potency Severity 7 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00006 7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Inhibition of brain cholinesterase in pups - The RfD for the parent covers the toxicity of the metabolite Decreased body wt. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.42 Y/N Y/N W/L W/L Prevalence Magnitude 2 7 Li HRL Ratio(s) NC HRL/NCOD R2 90%: 0.191 Notes Reference Dose; Basis = BMDL10 0.03 mg/kg-d; UF = 500. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PCBPBS Pesticde Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year 3,435,1973 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 3-Hydroxycarbofuran CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 24 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,700 18 0.14 1 66.3 2.2 2.2 66.3 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,539 Amount Released n PWSs/Sites/Sa mples 1 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 1 0.022 Number of States % PWSs/Sites/Sam pies with detects 0 0.4 0.07 Units States States States Minimum value of Detects Non-cancer: 0.191 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.07 Year Maximum value of Detects 0 0.062 0.07 0.07 0.07 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data ug/L ug/L Cancer: Notes Pesticide degradate Value 38 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- 4,4'-Methylenedianiline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 25 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 4,4'-Methylenedianiline 4202 101779 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.08 4.34 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 Critical Effect ntense liver degenerative lesions, hyperplasia of the stroma Liver - fatty liver degeneration, Kidney, Ureter, Bladder - interstitial nephritis, Blood - normocytic anemia Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.25 1.6 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 560 0.022 Y/N Y/N ug/L ug/L Prevalence Magnitude , 7 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 5 week oral study in dogs; JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year 11,367,1991 Supplemental Data Slope factor withdrawn Vol. 39, Suppl. 7; 1987 IARC, CACART, OEHHA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4,4'-Methylenedianiline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 26 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 96,446 168,919 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 2 10 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; corrosion nhibitor; curing agent for polyurethanes (HSDB) Value 4,950 1.59 1.58E-11 1,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Acephate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 27 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acephate 31325 30560191 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0012 0.004 0.004 0.03 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 1990 Critical Effect Brain ChE inhibition Brain and Coverings - other degeneratve changes, Autonomic Nervous System - sympathomimetic, Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.4 0.0087 C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1988 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 8.4 4 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 7 L' L HRL Ratio(s) NC HRL/SWC EEC: 1.17 CAR HRL/SWC EEC: 0.556 Notes Reference Dose; Basis = NOAEL 0.12 mg/kg-d; UF = 100. Reference Dose; Basis = LOEL females = 0.15 mg/kg-d; LOEL males = 0.12 mg/kg-d; Adjusted Basis Value = LOAEL 0.0004 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(ssue)/page/year 43,342,1987 Supplemental Data EPA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acephate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 28 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 2,462,354 0 20,751 Units Ibsfyr Ibs/yr Ibs/yr Number of States 35 0 5 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 7.2 ug/L Ground water chronic: 0.02 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.17 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.556 nsecticide (HSDB) Value 21.8 -0.85 5.02E-13 818,000 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BF Notes BF = biodegrades fast ------- Acetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 29 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetaldehyde 2622 75070 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - changes in motoractivity (specific assay) Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/DBP ICR MED: 3.15 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issueXpage/year PB234-882; 22-wk guinea pig study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1988 1999 Vol. 36, Suppl. 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 23.3 Y/N Y/N ug/L ug/L Teratogen list IARC, EPA, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acetaldehyde CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 30 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR # PWSs/Sites sampled 236 #with Detects 27 % PWSs/Sites with detects 11.44 Minimum value of Detects Maximum value of Detects 18.3 Median value of Detects T.4 Mean value of Detects 8.04 Units for Mag data ug/L Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 370,815 14,683,890 n PWSs/Sites/Sa mples 8 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 % Samples with detects Number of States 31 38 % PWSs/Sites/Sam pies with detects 37.5 Minimum value of Detects Units States States States Minimum value of Detects 1 Non-cancer: 3.15 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 24 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Notes Notes ug/L ug/L ug/L Units for Mag data ug/L ug/L National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2 90% of Detects 4 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide; food additive; chemica intermediate (HSDB) Value 1.498 -0.34 6.68E-05 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Acetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 31 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acetamide 2411 60355 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification o.or 2B mg/L (mg/kg-d)-1 (mg/kg-d)-' Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.5 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 7 9 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 32 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2,754 1,202,667 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 3 7 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; solubilizer; plasticizer; stabilizer (HSDB) Value 5 -1.26 1.21E-08 2,250,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes BF = biodegrades fast ------- Acetochlor CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 33 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor 32393 34256821 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 5.45 Units mg/kg-d mg*g-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect Salivation, increased ALT & omithine carbamyl transferase; increases in triglyceride & decreased blood glucose levels; histopathological changes in kidneys & testes Brain and Coverings - other degenerative changes, Blood - methemoglobinemia-carboxyhemoglobin, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - dehvdroaenases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 140 Y/N Y/N ug/L ug/L Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQ 90% : 179 Notes Reference Dose Reference Dose; Basis NOAEL 2 mg*g-d; UF = 100. ICI, Inc., 1988a Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 42-day study in rat; PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, PI. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year 15,96,1990 Supplemental Data CACART Drinking Water Equ valent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetochlor CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 34 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 115 69 #with Detects 0 293 5.02 Number of States 35 % PWSs/Sites/Sam pies with detects 35.6 30.3 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects Minimum value of Detects 0.026 Non-cancer: 179 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 0.334 0.395 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.022 95% of Detects 0.002 0.061 90% of Detects 1.5 Units ug/L ug/L Units ug/L ug/L Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/ drinkingwater/Pages/Chemicalcontaminants.aspx Herbicide (HSDB) Value 4.3 98.5-239 3.03 5.4E-11 233 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast (half-life is for soil) ------- Acetochlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 35 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor ethanesulfonic acid (ESA) 79191 187022113 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 1 1 Scores based on parent HEALTH EFFECTS DATA1 - See Acetochlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 23 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced body weights and body weight gains in both sexes Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 161 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 205 (NAWQA data for acetochlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acetochlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 36 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data - FOR ACETOCHLOR - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data - FOR ACETOCHLOR - PARENT NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ACETOCHLOR ESA POP finished water FOR ACETOCHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples 377 n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 5 #with Detects 0 293 5.020 Number of States 35 % PWSs/Sites/Sam pies with detects 1.3 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects 0.02 Minimum value of Detects 0.026 Non-cancer: 205 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 0.02 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes FOR ACETOCHLOR - PARENT Median value of Detects Median value of Detects 0.022 95% of Detects 90% of Detects 1.5 Units ug/L Units ug/L ug/L Cancer: Notes Pesticide Data Program (USD A); 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx NAWQA data for acetochlor - parent Pesticide degradate Value Units length of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Acetochlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 37 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acetochlor oxani ic acid (OA) 79193 194992444 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 1 1 Scores based on parent HEALTH EFFECTS DATA1 - See Acetochlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 23 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced body weights and body weight gains in both sexes Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 161 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 205 (NAWQA data for acetochlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR ACETOCHLOR OA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Acetochlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 38 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data FOR ACETOCHLOR - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,615 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data FOR ACETOCHLOR - PARENT N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water TRI Release - total Supplemental wate data FOR ACETOCHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters r,72, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 5,529 Amount Released 32,591,175 n PWSs/Sites/Sa mples 1,872 848 278 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 293 5.02 Number of States 35 % PWSs/Sites/Sam pies with detects 0 34.55 0.0011 Units States States States Minimum value of Detects 0.026 Non-cancer: 205 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 30.4 Year 1997 Maximum value of Detects 21 0.032 0.784 8.49 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes FOR ACETOCHLOR - PARENT Median value of Detects 0.022 90% of Detects 1.5 Units ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx NAWQA data for acetochlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Acrolein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 39 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acrolein 4581 107028 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 0.0005 0.0005 0.5 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2003 12/1990 Critical Effect Decreased survival Hemato. Liver - liver function tests impaired, Kidney, Ureter, Bladder - other changes Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1995 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 3 7 Li L HRL Ratio(s) NC HRL/NAWQA 90% : 1 .03 Notes Reference Dose Reference Dose; Basis = NOAEL 0.05 mg/kg-d; UF = 100. Parent, et. al, 1S92a Reference Dose Reference Dose (IRIS) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,385,1994 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Acrolein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 40 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 1,108 Amount Released 1 284,480 # PWSs/Sites sampled 2 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.18 Number of States 1 16 % PWSs/Sites with detects 1.3 Units States States States Minimum value of Detects Non-cancer: 1.03 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 3.4 Year 2004 2004 Maximum value of Detects 2.35 3.4 3.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Aquatic herbicide; rodenticide; industrial chemical (HSDB) Value 120-180 3 -0.01 1.22E-04 212,000 Units hours in water L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes pH = 7; BF = biodegradesfast ------- Alachlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 41 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Alachlor ethanesulfonic acid (ESA) 71246 142363539 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 157 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased incidence of clinical signs of toxicity in males and females and decreased body weight gains in males. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification 0.04 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,100 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, 93 NL Scores based on parent HRL Ratio(s) NC HRL/NAWQA 90% : 4,300 (NAWQA data for alachlor - parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP - FOR ALACHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data FOR ALACHLOR - PARENT Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Alachlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 42 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data - FOR ALACHLOR PARENT NAWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ALACHLOR ESA POP finished water POP finished water FOR ALACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,166 Amount Released n PWSs/Sites/Sa mples 79 233 n PWSs/Sites/Sa mples 8,112 2,111 568 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 76 #with Detects 3 361 7.9 Number of States % PWSs/Sites/Sam pies with detects 3.8 32.6 % PWSs/Sites/Sam pies with detects 0.0003 17.1 0.0008 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.24 0.0125 Non-cancer: 4,300 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 38.2 Year Maximum value of Detects 0.50 1.44 Maximum value of Detects 14 10.78 0.015 0.256 3.33 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 4.29 0.06 95% of Detects 90% of Detects 11.09 0.55 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USD A); 2001 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminant s.aspx NAWQA data for alachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- AlachlorOA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 43 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Alachlor oxanilic acid (OA) 79196 171262172 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.04 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 Y/N Y/N ug/L ug/L Prevalence Magnitude 93 Li Scores based on parent HRL Ratio(s) CAR HRL/NAWQA 90% : 1 .56 (NAWQA data for alachlor- parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FOR ALACHLOR - PARENT Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- AlachlorOA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 44 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data - FOR ALACHLOR PARENT NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data - FOR ALACHLOR OA POP finished water POP finished water FOR ALACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,166 Amount Released n PWSs/Sites/Sa mples 137 411 n PWSs/Sites/Sa mples 8,112 2,111 568 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 21 #with Detects 3 361 r.9 Number of States % PWSs/Sites/Sam pies with detects 0.07 5.1 % PWSs/Sites/Sam pies with detects 0.0003 17.1 0.0008 Units States States States Minimum value of Detects 0.50 0.121 Minimum value of Detects 0.24 0.0125 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 38.2 Year Maximum value of Detects 0.50 0.392 Maximum value of Detects 14 10.8 0.015 0.256 3.33 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 4.29 0.06 95% of Detects 90% of Detects 11.09 0.55 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: 1.56 Notes Pesticide Data Program (USDA); 2001 2002 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx NAWQA data for alachlor - parent Pesticide degradate Value Units ength of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- alpha-Hexachlorocyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 45 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): alpha-Hexachlorocyclohexane 6535 319846 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.008 1.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 9/2003 Critical Effect Hepatic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0006 6.3 2.7 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 56 0.006 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 3 Li HRL Ratio(s) NC HRL/NAWQA 90% : 949 CAR HRL/NAWQA 90%: 0.102 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; Basis NOAEL 0.8 mg/kg-d; UF = 1 00. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 56,137,1991 Supplemental Data IRIS EPA; RAIS; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- alpha-Hexachlorocyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 46 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,113 Amount Released # PWSs/Sites sampled 21 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.295 Number of States % PWSs/Sites with detects 0.0004 Units States States States Minimum value of Detects Non-cancer: 949 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.21 Year Maximum value of Detects 0.011 0.059 0.21 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.102 Notes Component of benzene hexachloride (BHC) former insecticide (HSDB) Value 1.2 641-1,995 3.8 6.70E-06 2 Units years L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes hydrolysis only, pH = 7; BST = biodegrades sometimes/reca citrant ------- Anatoxin-a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 47 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Anatoxin-a 80772 64285069 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Mortality Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 Y/N Y/N ug/L ug/L Prevalence Magnitude 9 8 L Scores based on supplemental data HRL Ratio(s) NC HRL/Cyano HABs MAX: -0.35 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis NOAEL 0.5 mg/kg-d. Astrachan, N.B. and B.G. Archer. 1981. Simplified monitoring of anatoxin-a by reverse-phase high performance liquid chromatography and the sub-acute effects of anatoxin-a in rats. In: The Water Environment: Algal Toxins and Health, W.W. Carmichael, Ed. Plenum Press, New York, NY. p. 437-446. Astrachan, N.B., B.G, Archer and D.R. Hilbelink. 1980, Evaluation of thesubacutetoxicity and teratogenicity of anatoxin- a. Toxicon. 18(5-6): 684-688. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Anatoxin-a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 48 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Prev: UCMR1 Meeting summary; Mag: CyanoHABs - The Florida Experience HRL Ratios (HRL/CyanoHABs MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 4 Units States States States Minimum value of Detects Non-cancer: -0.35 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects ~10 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L Cancer: Notes Prev: Lake Champlain, NY study; Mag: 2000 Florida study Cyanobacterial toxin Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Aniline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 49 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Aniline 2438 62533 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.007 0.007 2.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect Blood- effects; Spleen-effects spleen Blood - pigmented or nucleated red blood cells, Blood - methemoglobinemia-carboxyhemoglobin, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other esterases Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.6 0.0057 0.0057 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 spleen Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 49 6 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 98 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Provisional value; 104-week chronic study in rat for aniline hydrochloride. CUT, 1982. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; CIIT.1982; Basis LOAEL 7.2 mg/kg-d; rat; UF = 1,000 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 12 week oral study in rats; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 24(7), 44,1 959 Supplemental Data from IRIS Vol. 27, Suppl. 7; 1987 EPA, CACART, OEHHA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Aniline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 50 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 1,903 937,263 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 7 20 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemica ; as solvent; synthesis of explosives, rubber accelerators, isocyanates (HSDB) Value 44.78 0.9 2.02E-06 36000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- Bensulide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 51 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Bensulide 9553 741582 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 271 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma & brain ChE inhibition, decreased body weight gain Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 6 Li HRL Ratio(s) NC HRL/SWC EEC: 0.224 Notes Reference Dose; Basis = NOAEL 0.5 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year-,C42,1991 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bensulide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 52 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 545,406 Units Ibsfyr Ibs/yr Ibs/yr Number of States 34 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 158 ug/L Ground water chronic: 1 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.224 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide (HSDB) Value 9.15E-09 15 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- Benzyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 53 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Benzyl chloride 4107 100447 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 26.6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cardiac - other changes, Gastrointestinal - necrotic changes, Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.02 0.17 0.17 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1989 Thyroid Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 62 0.2 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 75 L' L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V. 61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year 76,1231,1986; 26 week oral study in rats Supplemental Data 2B from IARC Lijinsky, 1986 CACART, EPA, RAIS, OEHHA, IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 54 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, etal., 2006 HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 259 18,750 n PWSs/Sites/Sa mples 12 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 Number of States 3 10 % PWSs/Sites/Sam pies with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data Notes Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185. Cancer: Chemical intermed ate (NTP) Value 517.8 2.3 4.11E-04 20 27 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Butylated hydroxyanisole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 55 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Butylated hydroxyanisole 28160 25013165 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.249 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1959 Critical Effect Liver - changes in liver weight Prevalence Magnitude 8 4 NLi HRL Ratio(s) NC HRL/NREC NA GW MED: 0.484 CAR HRL/NREC NA GW MED: 146 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1 -64, 1 924-86. Volume(issue);page/year 37,533,1 959 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0002 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Vol. 40, Suppl. 7, 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.581 175 Y/N Y/N ug/L ug/L CACART; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butylated hydroxyanisole CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 56 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal.,2002 Focazio, etal., 2008 HRL Ratios (HRL/NREC NA GW MED) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 85 # Sam pies Amount Released n PWSs/Sites/Sa mples 2 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2.4 % Samples with detects 3 0.61 Number of States % PWSs/Sites/Sam pies with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.484 Amount Range >500K-1M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.2 Not detected 0.1 Median value of Detects 0.2 1.2 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: 146 Notes National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci. &Technol.,36(6), pp. 1202-1211. A national reconnaissance for Pharmaceuticals and other organic wastewater contaminants in the United States ~ II. Untreated drinking water sources. Focazio, etal., 2008. Sci. Tot. Env., 402(2-3), pp. 201- 216. Food additive (antoxidant) (HSDB) Value 38 days 1,390 3.5 1.17E-06 15 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Captan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 57 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Captan 5825 133062 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.13 0.13 0.1 19.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1995 Critical Effect Decreased pup body weight Kidney, Ureter, Bladder - other changes in urine composition, Blood - pigmented or nuceated red blood cells, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0024 0.0035 0.0023 3 mg/L (mgftg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 910 14.6 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/SWC EEC: 84.3 CAR HRL/SWC EEC: 1.35 Notes Reference Dose; Basis = NOEL 12.5 mg/kg-d; UF = 100 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 38(9), 24,1 973 Supplemental Data CACART; EPA; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Captan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 58 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 3,992,782 15 2,938 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 3 6 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 10.8 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 84.3 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 1.35 Fungicide (NTP) Value 862.2 2.8 7.01 E-09 5.1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades Sometimes/Reca citrant. However, hydrolysis half-life s 4.9 hrs - 1 8.8 hrs @ pH 7 and 5, respectively. ------- Chlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 59 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Chlorate 24376 14866683 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 5 1.4 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 Critical Effect Thyroid hypertrophy and mineralization Bone marrow hyperplasia; thyroid folicular hypertrophy and mineralization Blood - pigmented or nucleated red blood cells, Blood - changes in erythrocyte (RBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Not likely to be carcinogenic at doses that do not alter thyroid Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 10 HRL Ratio(s) NC HRL/DBP ICR 90% : 0.656 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data - NTP Abstract for TR-51 7; 2-year rat study for sodium chlorate Lowest Observed Adverse Effect Level; 1-year oral rat study fopr sodium chlorate; Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 60 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 1,713 #with Detects 1,490 % PWSs/Sites with detects 86.7 Mean value of Detects 172 Maximum value of Detects 2,234 Median value of Detects 120 90% of Detects 320 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 7,261,557 n PWSs/Sites/Sa mples 116 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 66 Number of States 16 % PWSs/Sites/Sam pies with detects 56.9 Units States States States Median of Detects 110 Non-cancer: 0.656 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 1997 2004 2004 Maximum of Detects 747 Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes For sodium chlorate Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.aspx Cancer: Agricultural defol ant or desiccant and in the production of CIO 2 (HSDB). Value 1,000,000 Units days L/kg unitless cm3/g atm-m3/mol mg/L Degradation Code Notes For sodium chlorate ------- Chloromethane (Methyl chloride) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 61 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloromethane (Methyl chloride 2605 74873 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.004 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Mild neurological effects in humans occupationally exposed to Chloromethane Cancer Data EPA Lifetime Cancer Risk, ICT* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.013 D 3 mg/L (mg/kg-d)-' (mg/kg-d)"1 1981 2001 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 28 2.69 Y/N Y/N mg/L ug/L ug/L 2006 developmental Teratogen Prevalence Magnitude , „ , 87 L' L HRL Ratio(s) NC HRL/NCOD R1 90%: 2.15 CAR HRL/NCOD R1 90%: 0.207 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CUT, 1981 Vol. 41,Suppl. 7, Vol. 71; 1999 CACART, RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Chloromethane (Methyl chloride) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 62 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NGOD Round 2 finished water NIRS finished water 20,246 23,478 248 528 1.22 2.25 0.01 0.00073 550 312 1.9 1.4 13 5 120 29 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Krasneretal., 2006 HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 3,959 Amount Released 1,539 1,733,197 n PWSs/Sites/Sa mples 11,984 12 356 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 247 1 8.99 Number of States 10 26 % PWSs/Sites/Sam pies with detects 2.1 8 0.007 Units States States States Minimum value of Detects 0.25 Non-cancer: 2.15 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 21 Year 2004 2004 Maximum value of Detects 46 0.04 0.1 0.58 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.7 ND 90% of Detects 2 Units for Mag data ug/L ug/L Cancer: 0.207 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Krasner, etal., 2006. Env. Sci. &Technol., 40(23), pp. 7175-7185. Foaming agent; in organic synthes s (HSDB); naturally-occurring gas Value 15 14 0.91 8.82E-03 5320 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Clethodim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 63 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Clethodim 76719 110429624 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 0.01 1,360 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Increased liver weights increased liver enzymes and iver histopathology Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 6 Li HRL Ratio(s) NC HRL/SWC EEC: 9.21 Notes Reference Dose; Basis = NOEL 1 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Oral study in rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year -,C272,1991 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Clethodim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 64 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 670,721 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data: OPP Estimated Environmental Concentration Surface water chronic: 7.6 ug/L Ground water chronic: 0.49 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 9.21 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide; pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Cobalt CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 65 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Cobalt 18870 7440484 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.01 0.0014 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2004 2000 Critical Effect Blood-increased hemoglobin, polycythemia; respiratory-effects on lung function Heart Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, _ 4 8 NL' HRL Ratio(s) NCHRL/NIRS90%:6.67 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; 'multiple studies as cited in ATSDR, 1992; UF = 30; human study; RIVM; Basis LOAEL = 0.04 mg/kg-d Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Vol. 52; 1991; NB: Evaluated as a group; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cobalt CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 66 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 3 0.303 6.4 10.6 9.7 10.5 10.6 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 3,297 Amount Released 1,272 786,491 # PWSs/Sites sampled 782 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 23.7 Number of States 17 38 % PWSs/Sites with detects 0.007 Units States States States Minimum value of Detects Non-cancer: 6.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 684 Year 2004 2004 Maximum value of Detects 0.22 3.91 53.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for cobaltous chloride: Formerly in medicines; as germicide (HSDB); naturally-occurring Value 534,200 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for cobaltous chloride; BST = biodegrades sometimes/reca citrant ------- Cumene hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 67 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cumene hydroperoxide 2927 80159 Attribute Scores Potency Severity 4 9 Prevalence Magnitude 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 32.7 382 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Mortality Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 76.4 Y/N Y/N ug/L ug/L 3-model Categorical Prediction L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issueXpage/year 19,205,1958; 7 week oral study in rats Supplemental Data Oral study in rats Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cumene hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 68 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 96 443,772 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 15 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (HSDB) Value 2.16 4.71 E-08 13,900 25 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation; PBT ------- Cylindrospermopsin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 69 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Cylindrospermopsin 81115 143545908 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00003 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg*g-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Increased kidney weight Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.21 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 5 10 L' Scores based on supplemental data HRL Ratio(s) c^notoxTsuryr00" *"** °" ""** NC HRL/CyanoHABs MAX: -0.0021 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis LOAEL 60 ug/kg-d; NOAEL 3 ug/kg-d. Humpage, A.R. and I.R. Falconer. 2003. Oral toxicity of the cyanobacterial toxin Cylindrospermopsin in male Swiss albino mice: Determination of no observed adverse effect level for deriving a drinking water guideline value. Environ. Toxicol. 18(2):94-103. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cylindrospermopsin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 70 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CyanoHABs - The Florida Experience UCMR 1 Meeting summary HRL Ratios (HRL/CyanoHABs MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects Not Available Not Available Units States States States Minimum value of Detects Non-cancer: -0.0021 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects -100 90 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: Notes 2000 Florida study Florida survey Cyanobacterial toxin Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dicrotophos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 71 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dicrotophos 6098 141662 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00007 0.0001 0.0001 11 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Decreased plasma, RBC & brain ChE activity Decreased body weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification Suggestive evidence mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.49 Y/N Y/N ug/L ug/L Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 2.45 Notes Reference Dose; Basis = LOAEL 0.02 mg/kg-d; UF = 300. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont, Canada) Volume(issue)/page/year 6,196,1973 OPP; no quantif cation Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dicrotophos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 72 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 359,726 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 13 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year Maximum value of Detects 0 0 Surface water chronic: 0.2 ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects 0 0 Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA); 2002 2002 Ground water chronic: 0.005 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 2.45 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 366.2 -0.49 5.05E-11 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Dimethipin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 73 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dimethipin 36818 55290647 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0218 0.02 0.02 0.02 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1999 Critical Effect Kidney, lungs, duodenum, liver, glandular stomach, heart, aortic artery & testes toxicity. Decreased body weight gain. ncreased absolute and relative liver weight Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 153 Y/N Y/N ug/L ug/L Prevalence Magnitude 8 5 Li HRL Ratio(s) NC HRL/GWC EEC: 1.55 Notes Reference Dose; Basis = NOEL 2.1 8 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethipin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 74 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 282,458 0 250 Units Ibsfyr Ibs/yr Ibs/yr Number of States 14 0 1 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 7.3 ug/L Ground water chronic: 99 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.55 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Herbicide; plant growth regulator (HSDB) Value 27.41 -0.17 2.30E-11 4,600 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation; PBT ------- Dimethoate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 75 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dimethoate 2413 60515 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0022 0.0002 0.0002 0.002 3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2007 1988 1996 Critical Effect Brain cholinesterase inhibition Brain cholinesterase nhibition Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)"1 2006 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 15.4 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 7 Li L HRL Ratio(s) NC HRL/SWC EEC: 0.655 Notes Reference Dose; OPP RED Reference Dose; Basis NOEL 0.05 mg/kg-d; UF = 100. American Cyanamid Co., 1986a Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level - 52-week study in rat; BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year21,52,1964 Supplemental Data OPP UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dimethoate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 76 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! Amount Released 1,896,947 2,615 31,480 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 7,238 890 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 4 #with Detects 0 14 Number of States 44 2 4 % PWSs/Sites/Sam pies with detects 1.3 % PWSs/Sites/Sam pies with detects 0 1.57 Units States States States Minimum value of Detects Minimum value of Detects 0.055 Year 1997 2004 2004 Maximum value of Detects 0.022 Maximum value of Detects 0.21 Surface water chronic: 23.5 ug/L Non-cancer: 0.655 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.148 95% of Detects 90% of Detects 0.198 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.044 ug/L Cancer: Pesticide (NTP) Value 8 5.2-36 0.78 2.43E-10 23,800 36 Units weeks L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation ------- Disulfoton CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 77 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Disulfoton 6423 298044 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00013 0.00004 0.0001 0.00004 0.00006 0.0003 0.06 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2002 1986 2006 08/1995 1991 Critical Effect Plasma, RBC, brain & corneal ChE inhibition Brain and Coverings - other degenerative changes, Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification E mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0035 0.91 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 1 1 NL HRL Ratio(s) NCHRL/NAWQA90%: 1.1 Notes Reference Dose; Basis = NOAEL 0.013 mgrtsg-d; UF = 100. Reference Dose; Basis = LOAEL 0.04 mg/kg-d; UF = 1 ,000. Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue)/page/year35,101,1997 Supplemental Data, ITER Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Disulfoton CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 78 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 1,196,066 n PWSs/Sites/Sa mples 17 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 0.24 Number of States 33 % PWSs/Sites/Sam pies with detects 0 0 0.002 Units States States States Minimum value of Detects Non-cancer: 1.1 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 3.81 Year 1997 Maximum value of Detects Not Detected Not Detected 0.02 0.826 3.81 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA); 2002 2002 nsecticide (HSDB) Value 7-41 684-14,013 4.02 2.20E-06 16.3 17 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades Slowly ------- Diuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 79 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Diuron 6583 330541 Attribute Scores 3-model Categorical Prediction Potency Severity 6 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.002 0.003 0.002 1.75 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 Critical Effect Hemolytic anemia & compensatory hematopotesis (decreased erythrocyte count, hemoglobin level, etc). Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Liver - changes in liver weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases Cancer Data EPA Lifetime Cancer Risk, 104 EPA OPP Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0191 Known/Likely mg/L (mg/kg-d)-1 (mg/kg-d)-1 2003 2003 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 21 1.83 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 4 7 NL! HRL Ratio(s) NCHRL/UCMR90%: 10 CAR HRL/UCMR 90%: 0.871 Notes Reference Dose; du Pont, 1364a; Basis = LOAEL 1 .0 mg/kg-d; UF = 300. Reference Dose; Basis NOEL 0.625 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day study in rat; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year36,76,1990 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. EPA, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diuron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 80 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 298 1 0.34 2.1 2.1 2.1 2.1 2.1 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water PPMP ambient water PPMP finished water HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,552 Amount Released 4,370,448 10 798 n PWSs/Sites/Sa mples 270 319 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 117 13 7.00 Number of States 39 2 5 % PWSs/Sites/Sam pies with detects 0.4 37.5 5.8 0.0004 Units States States States Minimum value of Detects 0.058 Non-cancer: 10 Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 23.3 Year 1997 2004 2004 Maximum value of Detects 0.058 0.54 0.079 0.09 0.915 8.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects 0.319 0.079 Units ug/L ug/L ug/L Cancer: 0.871 Notes Pesticide Data Program (USDA); 2002 Herbicide (HSDB Value 224-879 2.68 5.8E-10 36.4 15 Units months L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes BST = biodegrades sometimes/recalcitrant ------- Equilenin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 81 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Equilenin 81750 517099 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 9 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) NC HRL/Kolpin MAX: 1.26 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Equilenin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 82 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 2.8 Units States States States Minimum value of Detects Non-cancer: 1.26 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.278 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.14 90% of Detects Units for Mag data ug/L Notes National Surfac Sci.&Technol e Water Reconnaissance; Kolpin, etal., 2002. Env. 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 3.93 1.52 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Equilin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 83 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Equilin 81748 474862 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 8 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) NC HRL/Kolpin MAX: 2.38 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Equilin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 84 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples ro Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 1.4 Units States States States Minimum value of Detects Non-cancer: 2.38 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.147 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.147 90% of Detects Units for Mag data ug/L Notes National Surfac Sci. & Technol e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Cancer: Pharmaceutical, hormone Value 38 3.35 1.41 13 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Erythromycin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 85 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Erythromycin 75632 114078 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0007 66.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Inhibition of beneficial gastrointestinal bacteria Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4.9 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 HRL Ratio(s) NC HRL/NREC MAX: 2.88 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Da ly Dose (MRDD) UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Erythromycin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 86 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Focazio, etal., 2008 HRL Ratios (HRL/NREC MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 104 90 Amount Released n PWSs/Sites/Sa mples 22 0 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 21.5 0.0 Number of States % PWSs/Sites/Sam pies with detects Not detected Units States States States Minimum value of Detects Non-cancer: 2.88 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.7 Not detected Year Maximum value of Detects 0.3 0.1 Not detected Not detected Not detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 90% of Detects Units for Mag data ug/L Notes Drinking water monitoring; Focazio, etal., 2008. Sci.Tot. Env. 402(2-3), pp. 201-216. Cancer: Pharmaceutica , antibiotic Value 180 3.06 5.20E-29 6 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Estradiol (17-beta estradiol) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 87 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Estradiol (17-beta estradiol) 2130 50282 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormona response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 39 1 mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.35 0.0009 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude , 10 5 L HRL Ratio(s) NC HRL/Kolpin MAX: 1.75 CAR HRL/Kolpin MAX: 0.0045 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IARC, CACART, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Estradiol (17-beta estradiol) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 88 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 10.6 Units States States States Minimum value of Detects Not detected Non-cancer: 1.75 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected 0.0064 0.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 0.16 90% of Detects Not detected Units for Mag No(es data ug/L ug/L ug/L Cancer: 0.0045 Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. National Surface Water Reconnaissance; Kolpin, et al., 2002. Env. Sci.&Techno ., 36(6), pp. 1202-1211. Pharmaceutical, hormone Value 38 4.01 6.40E-11 3.6 11 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Estriol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 89 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Estriol 75525 50271 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 10 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.35 Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/Kolpin MAX: 6.86 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Estriol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 90 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 0.0 21.4 Units States States States Minimum value of Detects Not detected Not detected Non-cancer: 6.86 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected Not detected 0.051 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected Not detected 0.019 90% of Detects Not detected Not detected Units for Mag data ug/L ug/L ug/L Cancer: Notes Finished Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al, 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. National Surfac Sci. & Techno . e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Pharmaceutica , hormone Value 38 2.45 1.33E-12 441 17 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Estrone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 91 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Estrone 2210 53167 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JECFA ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Estrogenic hormonal response in post-menopausal women Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.35 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 9 3 Li HRL Ratio(s) NC HRL/Swartz MAX: 2.92 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake for E2 Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Estrone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 92 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Boyd, etal.,2003 Snyder, 2008 Kolpin.etal., 2002 Swartz, etal.,2006 HRL Ratios (HRL/Swartz MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 7.1 Units States States States Minimum value of Detects Not detected Non-cancer: 2.92 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not detected 0.002 0.112 0.12 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 0.027 90% of Detects Not detected Units for Mag No(es data Finished Drinking Water; Boyd, etal, 2003. Sci. Tot. Env. 311(1-3): pp. 135-149. ug/L ug/L ug/L Cancer: Raw Drinking Water; Snyder, et al, 2008. Removal of Endocrine Disrupters and Pharmaceuticals during Water Treatment. In: Fate of Pharmaceuticals in the Environmental and in Water Treatment Systems. National Surfac Sci. & Technol e Water Reconnaissance; Kolpin, et al., 2002. Env. 36(6), pp. 1202-1211. Ambient Water (SW/GW); Swartz, et al., 2006. Env. Sci. & Technol. 40(16): pp. 4894-4902. Pharmaceutical, hormone Value 38 3.13 3.80E-10 30 13 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Ethinyl Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 93 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethinyl Estradiol (17-alpha ethynyl estradiol) 2327 57636 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GGT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.337 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, etal., 1981 as cited in Maier and Hermann, 2001. Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethinyl Estradiol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 94 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Snyder, etal., 2007 Kolpin, etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 0.0 0.0 5.7 Units States States States Minimum value of Detects (ug/L) Not detected Not detected Non-cancer: 0.337 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects (ug/L) Not detected Not detected 0.273 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects (ug/L) Not detected Not detected 0.094 90% of Detects (ug/L) Not detected Not detected Units for Mag data ug/L ug/L ug/L Cancer: Notes Finished Drinking Water; Snyder, et al., 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Raw Drinking Water; Snyder, et al., 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Response to Comment on National Surface Water Reconnaissance Kolpin et al., 2002: Env. Sci. & Technol., 36(18), pp. 4007-4008. Pharmaceutical, hormone Value 60 3.67 7.94E-12 11.3 9 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Ethoprop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 95 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethoprop 22682 13194484 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.0004 33 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Plasma ChE inhibition, Q1* 0.0281 (mg/kg-day)-1 - Likely. Behavioral - changes in motor activity (specific assay), Behavioral - muscle contraction or spasticity Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.12 0.0281 Likely mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.7 1.25 Y/N Y/N ug/L ug/L Prevalence Magnitude ,,, _ 7 3 NL' HRL Ratio(s) NC HRL/NAWQA 90%: 7.29 CAR HRL/NAWQA 90%: 13 Notes Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 1 ,693,2001 OPP RED and Ethoprop pesticide tolerances: 73 FR 53725, Spetember 17, 2008 CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethoprop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 96 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 1,010,807 0 77,786 n PWSs/Sites/Sa mples 84 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 1.18 Number of States 28 0 4 % PWSs/Sites/Sam pies with detects 0 0 0.002 Units States States States Minimum value of Detects Non-cancer: 7.29 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.95 Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected 0.011 0.096 0.8 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Cancer: 13 Notes Pesticide Pilot Mentoring Program (USGS/EPA); 2001 2001 nsecticide (HSDB) Value 75-133 70-120 3.59 1.70E-07 750 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes hydrolysis only: BST = biodegrades sometimes/recalcitrant ------- Ethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 97 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene glycol 4599 107211 Attribute Scores Potency Severity 3 9 Prevalence Magnitude 10 10 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2 2 2 0.8 0.05 600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2006 2007 2000 Critical Effect Kidney toxicity. Increased mortality, neutrophil count, kidney hemoglobin & hematocrit, chronic nephritis ncreased total malformations and incidence of extra rib 14 in developmental study Kidney Behavioral - fluid intake, Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 14,000 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen 3-model Categorical Prediction L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; DePass et al., 1986a; UF = 100; Rat; Basis NOAEL = 200 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Gaunt etal., 1974; UF = 1,000; Rat Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2 year oral study in rate; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year3,229,1965 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 98 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 576,990 10,076,483 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 31 49 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Antifreeze; cancelled pesticide; synthetic chemical used in textile manufacture (NTP) Value 1 -1.36 6.00E-08 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Ethylene Oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 99 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene Oxide 2635 75218 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 1.02 0.31 1 mg/L (mg/kg-d)-1 (mg/kg-d)-' 1994 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.113 Y/N Y/N ug/L ug/L Teratogen; Developmental Prevalence Magnitude 10 8 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HEAST CACART; RAIS; OEHHA; EPA; IARC UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylene Oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 100 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 4,761 374,110 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 4 38 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fumigant (NTP); gas Value 1.435 -0.3 1.48E-04 1,000,000 43 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes PBT; BS = biodegrades slowly ------- Ethylene thiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 101 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethylene thiourea 3836 96457 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0002 0.00008 0.00008 0.00008 0.004 1.34 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 2006 1993 Critical Effect Thyroid toxicity ncreased incidence of thyroid hyperplasia Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.006 0.06 0.045 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 1988 2001 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.003 1.4 0.06 Y/N Y/N mg/L W/L W/L 2006 Teratogen; Developmental Prevalence Magnitude 4 1 NLi HRL Ratio(s) NC HRL/GWC EEC: 6.67 CAR HRL/GWC EEC: 0.286 Notes Reference Dose Reference Dose; Basis LOAEL 0.25 mg/kg-d. Graham etal., 1975 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 8-week study in rat; JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/vear 21,324,1973 Supplemental Data OPP OPP EPA; RAIS; OEHHA; IARC; CACART UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ethylene thiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 102 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 5 299 Units Ibs/yr Ibs/yr Ibsfyr Number of States 1 4 Units States States States Year 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 0.1 ug/L Ground water chronic: 0.21 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 6.67 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.286 Pesticide (NTP) Accelerator; industrial intermediate (HSDB) Value 15 6.5 -0.66 3.40E-07 20,000 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly (at 30 C) ------- Fenamiphos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 103 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Fenamiphos 27401 22224926 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.00025 0.0001 0.00025 0.0008 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 2006 1997 Critical Effect Plasma ChE inhibition. Cholinesterase inhibit on Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification E mg/L (mg/kg-d)-1 (mg/kg-d)"1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0035 0.7 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 0.051 Notes Reference Dose; Basis = NOAEL 0.01 mg/kg-d; UF = 100. Reference Dose; Basis = NOEL 0.025 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. OPP changed cancer classification from D to E. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fenamiphos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 104 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 726,675 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 14 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 Maximum value of Detects Not Detected Not Detected Surface water chronic: 13.7 ug/L Non-cancer: 0.051 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.47 ug/L Cancer: nsecticide (HSDB) Value 225.1 3.23 1.21E-09 329 12 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation; PBT ------- Formaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 105 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Formaldehyde 2119 50000 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.2 0.2 0.2 12.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 2006 1999 Critical Effect Reduced weight gain, histopathology in rats. Decreased absolute heart, liver, testes & kidney weights. Increased relative brain, testes weights. Gastro. Liver - other changes, Blood - changes in spleen Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification B1 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 1993 1995 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 7 1,400 Y/N Y/N ug/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) NC HRL/DBP ICR MED: 184 Notes Reference Dose Reference Dose; Basis = NOAEL 15 mg/kg-d; UF = 100. Til etal., 1989 Reference Dose Reference Dose Minimal Risk Level; Basis = NOAEL 15 mg/kg-d; ATSDR MRL-int = 0.3 mg/kg-d (Til etal., 1989). Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,339,1994 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART; EPA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Formaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 106 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR # PWSs/Sites sampled 227 #with Detects 126 % PWSs/Sites with detects 55.5 Minimum value of Detects 5 Maximum value of Detects 30.6 Median value of Detects 7.6 99% of Detects 29.7 Units for Mag data ug/L Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 326,298 26,992,234 Units Ibs/yr Ibs/yr Ibs/yr Number of States 31 46 Units States States States Non-cancer: 184 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Units for Mag data ug/L ug/L ug/L Notes Notes ug/L ug/L ug/L ug/L ug/L National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Cancer: Naturally-occurring fungicide (NTP); Disinfection by-Product; gas Value 1 0.35 3.38E-07 400,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- Germanium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 107 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Germanium 18876 7440564 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.318 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.744 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 10 Li HRL Ratio(s) NC HRL/NIRS 90% : 0.003 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POBS272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page;year 30,67,1991. EPA believes the RTECS LOAEL may be incorrectly cited (should be 3.18 not 0.318). Both values suggest listing germanium. Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Germanium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 108 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 4 0.40 2B 230 220 220 230 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.003 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for germanium diox de: Phosphors, transistors and diodes; electroplating (HSDB); naturally-occurr ng Value 4,470 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for germanium dioxide; BST = biodegrades sometimes/reca citrant ------- Halon 1011 (bromochloromethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 109 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Halon 1011 (bromochloromethane) 2613 74975 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased liver-to-body weight ratio. Cloudy swelling and vacuolization of hepatocytes. Prevalence Magnitude 5 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 7 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.5 70 Y/N Y/N mg/L ug/L ug/L 2006 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For care nogens, the concentration at the 1 0 "6 cancer risk was used. ------- Halon 1011 (bromochloromethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 110 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NGOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,881 22,974 65 106 0.5 0.461 0.05 0.0023 210 33.4 1 1 10 6 210 27.9 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Krasner, etal., 2006 HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1/2, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,238 ^Samples Amount Released n PWSs/Sites/Sa mples 7 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.165 % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 0.1 0.0 0.01 Minimum value of Detects Units States States States Minimum value of Detects Not detected Non-cancer: 7 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.45 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not detected 0.2 Median value of Detects 0.422 90% of Detects 0.45 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1 Not detected 99% of Detects Not detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Krasner, etal., 2006. Env. Sci. &Technol. 40 (23): pp. 7175-7185. Fire extinguishing fluid; chemical intermediate (HSDB) Value 15 days 23.7 1.41 0.00146 16,700 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- HCFC-22 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 111 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): HCFC-22 2654 75456 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 13.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1983 Critical Effect Brain and Coverings - other degenerative changes, Blood - changes in other cell count (unspecified), Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 31.5 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 10 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 48(8),69,1983 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- HCFC-22 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 112 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 2,972 7,075,769 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 35 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Refrigerant; low-temperature solvent; fluorocarbon resins, especially tetrafluoroethylene polymers (HSDB); gas Value 15 35.04 1.08 4.07E-02 2,770 43 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Hexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 113 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Hexane 4858 110543 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.06 1,429 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 Critical Effect Decreased body weight gain Nutritional and Gross Metabolic - weight loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 420 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 10 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis LOAEL = 570 mg/kg-d, UF = 10,000, oral rat study. Health and Environmental Effects Document for n-Hexane, ECAO-CIN-Q076, Environmental Criteria and Assessment Office, Final Draft, September 1989. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year 1(3), 67,1985 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 114 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 14,489 39,844,882 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 38 53 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Naturally-occurring; solvent (NTP) Value 149 3.9 1.8 9.5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- Hydrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 115 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Hydrazine 6460 302012 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.001 3 3 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.01 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 9 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; IARC; OEHHA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 116 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 5 165,485 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 16 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; rocket propellant; oxygen/chlorine scavenger (HSDB) Value 14.3 -2.07 1.44E-08 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 117 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Mestranol 2581 72333 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL (for ethinyl estradiol) Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.00083 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanineaminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GOT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 94 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.688 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 . Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 118 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Mestranol 2581 72333 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL (for ethinyl estradiol) Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.015 0.00083 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1981 Critical Effect Hematalogical effects Increased serum levels of alanineaminotransferase (ALT), aspartate aminotransferase (AST) and y- glutamultransferase (GOT). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.28 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 94 Li HRL Ratio(s) NC HRL/Kolpin MAX: 0.688 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data; Maier and Hermann, 2001 . Regulatory Toxicology and Pharmacology, 34, pp 53-61 . Lowest Observed Adverse Effect Level Supplemental Data; Tennant, et al., 1981 as cited in Maier and Hermann, 2001 . Supplemental Data; Maximum Recommended Da ly Dose (MRDD) CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Mestranol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 119 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin.etal., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 4.3 Units States States States Minimum value of Detects Non-cancer: 0.688 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.407 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.017 90% of Detects Units for Mag data ug/L Notes Response to Comment on National Surface Water Reconnaissance Kolpin et al., 2002: Env. Sci. & Technol, 36(18), pp. 4007-4008. Cancer: Metabolite of ethinyl estradiol Value 60 4.68 Practically insoluble 9 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Methamidophos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 120 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 965,584 Units Ibsfyr Ibs/yr Ibs/yr Number of States 39 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 6.9 ug/L Ground water chronic: 3.8 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.304 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 3.848 -0.8 8.70E-10 1000000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Methanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 121 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methanol 2508 67561 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 0.5 3.13 5,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect ncreased SAP & SGPT& liver weight, decreased brain weight Liver - other changes Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 10 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S. EPA, 1986; Basis = NOEL 500 mg(kg-d; UF = 1,000; Rat Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 200 day oral study in rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year - ,89,1994 Supplemental Data Rats; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,87,1984 UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 122 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 10,966,234 201,697,278 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 41 52 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; gasoline additive (HSDB); anti-freeze Value 1 -0.77 4.56E-06 1000000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- Methyl bromide (Bromomethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 123 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Methyl bromide (Bromomethane 2601 74839 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0014 0.001 0.0014 0.003 1 29.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 9/1992 1966 Critical Effect Epithelial hyperplasia in theforestomach Gastro Kidney, Ureter, Bladder - other changes in urine composition, Skin and Appendages - hair, Nutritional and Gross Metabolic - we ght loss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 1989 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.05 9.8 Y/N Y/N mg/L ug/L ug/L 2006 Developmental Prevalence Magnitude , „ 67 L HRL Ratio(s) NC HRL/NCOD R1 90%: 0.891 Notes Reference Dose Reference Dose; Basis = NOAEL 1 .4 mg/kg-day; UF = 1 ,000; Rat. Danse et al.r 1984 Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year28,109,1990 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl bromide (Bromomethane) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 124 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,198 23,328 155 175 0.77 0.75 0.07 0.09 43 38.1 1 1.6 11 8.1 34 27.2 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,317 Amount Released 32,803,943 200 533,748 # PWSs/Sites sampled 3 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.069 Number of States 29 3 17 % PWSs/Sites with detects 0.04 Units States States States Minimum value of Detects Non-cancer: 0.891 Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.5 Year 1997 2004 2004 Maximum value of Detects 0.1 0.5 0.5 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled fumigant (NTP); gas Value 20-26.7 9-22 1.19 7.34E-03 13,400 42 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes hydrolysis only; BS = biodegrades slowly ------- Methyl tert-butyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 125 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Methyl tert-butyl ether 11918 1634044 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 0.01 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 8/1996 1991 Critical Effect Hepatic: Decreased blood urea nitrogen levels. Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - changes in calcium Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0018 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 2,100 19.4 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 58 L' HRL Ratio(s) NC HRL/UCMR 90%: 58.3 CAR HRL/UCMR 90%: 0.539 Notes Reference Dose Reference Dose Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Basis NOAEL 100 mg/kg-d Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in rat; JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year 9(5), 525, 1990 Supplemental Data OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl tert-butyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 126 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,617 17 0.47 5 49 9.2 36 49 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,328 Amount Released 40,177 2,040,906 # PWSs/Sites sampled 424 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 9.8 Number of States 17 42 % PWSs/Sites with detects 0.01 Units States States States Minimum value of Detects Non-cancer: 58.3 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 2,300 Year 2004 2004 Maximum value of Detects 0.3 7.85 1,800 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 0.539 Notes Octane booster in gasoline; manufacture of isobutene; extraction solvent (HSDB) Value 15 6 0.94 5.87E-04 51,000 46 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Metolachlor CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 127 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor 35270 51218452 Attribute Scores Potency Severity 4 3 Prevalence Magnitude 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.15 0.1 0.15 25 1,150 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 1988 2006 Critical Effect Decreased body weight gain Decreased body weight gain Behavioral - food intake (animal), Nutrtional and Gross Metabolic - weight loss or decreased weight gain, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 700 Y/N Y/N mg/L ug/L ug/L 2006 3-model Categorical Prediction NL? HRL Ratio(s) NC HRL/NCOD R2 90%: 321 Notes Reference Dose; Basis NOAEL = 9.7 mg/kg-d; UF = 100. OPP RED. Reference Dose; Basis = NOEL 15 mg/kg-d; UF = 100. Ciba-Geigy, 1983 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989 Supplemental Data NNGADV Nippon Noyaku Gakka shi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year 14,103,1989 Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 ~6 cancer risk was used. ------- Metolachlor CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 128 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,165 Amount Released 67,336,211 n PWSs/Sites/Sa mples 203 582 n PWSs/Sites/Sa mples 7,345 2,082 1,817 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 102 233 288 198 #with Detects 15 676 25.4 8.76 1.23 Number of States 48 % PWSs/Sites/Sam pies with detects 50.2 40 89.2 86.8 % PWSs/Sites/Sam pies with detects 0.2 32.5 0.0002 Units States States States Minimum value of Detects 0.01 0.005 Minimum value of Detects 0.05 0.00867 Non-cancer: 321 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 77.6 Year 1997 Maximum value of Detects 0.079 0.226 3.32 0.661 Maximum value of Detects 0.7 86 0.025 0.12 0.125 0.58 6.71 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 0.033 0.336 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 2002 Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 47;78 22-310 3.13 9.00E-09 530 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes aerobic;anaerobic; BSA = biodegrades slow with acclimaton ------- Metolachlor ESA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 129 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor ethanesulfonic acid (ESA) 79218 171118095 Attribute Scores Potency Severity 2 1 Prevalence Magnitude 6 6 Scores based on parent HEALTH EFFECTS DATA1 - See Metolachlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 21000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No biologically significant effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer >7,000 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : >3,210 (NAWQA data for metolachlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR ESA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Metolachlor ESA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 130 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag No(es data Finished Water Occurrence Data - FOR METOLACHLOR PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water FOR METOLACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NCOD R290%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 83 318 n PWSs/Sites/Sa mples 7,345 2,082 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 19 198 #with Detects 15 676 Number of States % PWSs/Sites/Samp les with detects 22.9 51.9 % PWSs/Sites/Samp les with detects 0.2 32.5 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.05 0.00867 Non-cancer: >3,210 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 2.21 2.24 Maximum value of Detects 0.7 86 ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR ESA 2002 - FOR METOLACHLOR ESA Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants.as px NCOD data for metolachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Metolachlor OA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 131 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Metolachlor oxani ic acid (OA) 79220 152019733 Attribute Scores Potency Severity 2 1 Prevalence Magnitude 6 6 Scores based on parent HEALTH EFFECTS DATA1 - See Metolachlor Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No biologically significant effects Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7,000 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) HRL/NAWQA 90% : 3,210 (NAWQA data for metolachlor parent) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; EPA OPP NOAEL - FOR METOLACHLOR OA Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Metolachlor OA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 132 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag No(es data Finished Water Occurrence Data - FOR METOLACHLOR PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,007 116 0.89 0.01 13.8 0.57 2.18 7.1 Ambient Water Occurrence Data N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water FOR METOLACHLOR - PARENT CAL DHS STORE! HRL Ratios (HRL/NCOD R290%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KQC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 138 404 n PWSs/Sites/Sa mples 7,345 2,082 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 14 152 #with Detects 15 676 Number of States % PWSs/Sites/Sam pies with detects 10.1 37.6 % PWSs/Sites/Sam pies with detects 0.2 32.47 Units States States States Minimum value of Detects 0.50 0.02 Minimum value of Detects 0.05 0.00867 Non-cancer: 3,210 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 4.42 1.41 Maximum value of Detects 0.7 86 ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.06 0.19 95% of Detects 90% of Detects 0.1 1.4 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 - FOR METOLACHLOR OA 2002 - FOR METOLACHLOR OA Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminants. aspx NCOD data for metolachlor - parent Pesticide degradate Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Microcystin-LR CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 133 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Microcystin-LR 76859 101043372 Attribute Scores 3-model Categorical Prediction Potency Severity 9 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.000003 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Liver effects Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.021 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 4 Scores based on supplemental data HRL Ratio(s) NC HRL/AWWARF Typical Range MAX: 0.21 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data - draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y., Y. Makita, S. Nagata et al. 1 999. No chronic oral toxicity of a low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female Balb/C mice. Environ. Toxicol. 14(1):45-55. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Microcystin-LR CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 134 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data US and Canadian drinking water (bloom area, source, finished water) US and Canadian drinking water (bloom area, source, finished water) HRL Ratios (HRL/AWWARF Typical Range MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 677 677 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 542 542 Number of States % PWSs/Sites/Sam pies with detects 80 80 Units States States States Minimum value of Detects 0.002 Non-cancer: 0.21 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.1 1,200 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: Notes Maximum of typical range of detects (AWWARF, Carmichael) Maximum and m numum of detects (AWWARF, Carmichael) Cyanobacterial toxin Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Molinate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 135 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Molinate 12912 2212671 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.002 0.002 13.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1988 Critical Effect Degeneration/demyelination in sciatic nerve and atrophy/reserve cell hyperplasia of muscle Reproductive toxicity. Alteration in sperm morphology, reduced number of viable fetuses/litter, increased number of resorptions/litter Endocrine - other changes, Blood - normocytic anemia, Nutritional and Gross Metabolic - body temperature decrease Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ 1 8 L' HRL Ratio(s) NCHRL/UCMR90%: 2.46 Notes Reference Dose; Basis LOAEL = 0.3 mg/kg-d, UF = 300, 2-year rat study. A Determination of the Existence of a Common Mechanism of Toxicity and a Screening Level Cumulative Food Risk Assessment, December 2001. OPP issued RfD as part of health assessment not the RED; http://epa.gov/oppsrrd1/cumulative/thiocarb.pdf Reference Dose; Basis NOEL 0.2 mg/kg-d; UF = 100. Stauffer Chemical Co., 1981 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 43 week study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(1 0) , 1 04, 1 975 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Molinate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 136 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,621 1 0.03 5.7 5.7 5.7 5.7 5.7 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 3,669,398 115 2,089 n PWSs/Sites/Sa mples 120 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 1.68 Number of States 6 1 2 % PWSs/Sites/Sam pies with detects 0.3 0.001 Units States States States Minimum value of Detects Non-cancer: 2.46 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 200 Year 1997 2004 2004 Maximum value of Detects 0.004 0.0372 3.41 47.9 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units ug/L Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA) Herbicide (HSDB) Value 40-160 80-120 3.21 4.10E-06 970 19 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation code BST Notes BST = biodegrades sometimes/recalcitrant ------- Molybdenum CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 137 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Molybdenum 18825 7439987 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.005 0.005 0.03 0.5 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2006 Critical Effect increased uric acid levels Effects on repro & fetal development (decreased gestational weight ga n, prolonged estrus cycle, failure to breed). Renal failure, diuresis, proteinuria Liver - other changes, Kidney, Ureter, Bladder - other changes, Nutritional and Gross Metabolic - weight loss or decreased weight ga n Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.2 35 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen List Prevalence Magnitude 98 Li HRL Ratio(s) NCHRL/NIRS90%: 1.17 Notes Reference Dose Reference Dose; Koval'skiy et al.( 1961; oral study in humans; UF = 30; Basis LOAEL = 0.14 mg/kd- d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; UL; IOM No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 9 week oral study in rabbits; VCVN5 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989. Volume(issue)/page/year -, 317, 1989 Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Molybdenum CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 138 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 77 7.79 6.1 180 10 30 110 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 1.17 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data for molybdenum trioxide: As steel alloy; chemical reagent (HSDB); naturally-occurring Value 1,066 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data for molybdenum trioxide; BST = biodegrades sometimes/reca citrant All use and env. fate data for molybdenum trioxide ------- Nitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 139 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Nitrobenzene 3998 98953 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.0005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2009 Critical Effect Increased reticulocytesand methemaglobinemia Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1990 1996 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 14 Y/N Y/N ug/L ug/L Teratogen List Prevalence Magnitude 1 10 NLi HRL Ratio(s) NCHRL/UCMRAM90%: 0.14 Notes Reference Dose Reference Dose; NTP, 1983; subchronic rat study; UF = 1,000; Basis BMDL = 1.8 mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. CACART, IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 140 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,064 2 0.065 21. 6 100 60.8 100 100 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data UCMR finished water HRL Ratios (HRL/UCMR AM 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 60 350,301 # PWSs/Sites sampled 338 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States 1 14 % PWSs/Sites with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: 0.14 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes Analyzed under UCMR 1 , List 1 , Assessment Monitoring with detection limit of 10 ug/L. National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data Not Detected Cancer: Notes Analyzed under UCMR 1, List 2, Screening Survey with detection limit of 0.5 ug/L. Solvent (NTP) Value 15 30.6-370 1.85 2.40E-05 1,800 31 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = biodegrades slowly ------- Nitroglycerin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 141 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Nitroglycerin 2252 55630 Attribute Scores Potency Severity 7 6 Prevalence Magnitude 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.125 0.008 105 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cardiac - cardiomyopathy including infarction, Cardiac - EKG changes not diagnostic of specified effects, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.2 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.292 2 Y/N Y/N ug/L ug/L Teratogen 3-model Categorical Prediction L?-L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26 week oral study in rats; FATOAO Farmakologiya i Toksikologiya (Moscow), For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year 48,76,1985 Supplemental Data; RTECS LOAEL, acute human study Oral study in rats; YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year 13,3649,1985 EPA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitroglycerin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 142 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0.2 55,979 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 9 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pharmaceutical/medication; production of explosives; Rocket propellants; (HSDB) Value 1.62 9.87E-08 1,380 32 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- N-Methyl-2-pyrrolidone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 143 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Methyl-2-pyrrolidone 9980 872504 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 120 3,914 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Decreased weight gain, neurobehavioral effects, sedative effects Endocrine - changes in spleen weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4,200 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 10 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Tolerable Daily Intake; Basis NOAEL = 169 mg/kg-d, UF = 300, 90-day rat study, WHO/UNEP CICAD TDI Study #35 No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientif c & Technical Information. Volume(issue)/page/year OTS0528073 Supplemental Data ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(ssue)/page/year 26,1581,1976 UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- N-Methyl-2-pyrrolidone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 144 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 17,972 6,311,503 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 13 42 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical industry solvent; solvent for pesticide appl cation for food packing materials (HSDB) Value -0.38 3.20E-09 1,000,000 42 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades Fast ------- N-Nitrosodiethylamine (NDEA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 145 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosodiethylamine (NDEA) 2243 55185 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.00002 150 36 B2 2A mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.0002 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 1 2 Li HRL Ratio(s) See also supplemental water data No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA; OEHHA; IARC; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosodiethylamine (NDEA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 146 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 1,000 n PWSs/Sites/Sa mples 26 26 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 0 Number of States 0 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Not Detected Not Detected Non-cancer: Amount Range Gasoline and lubr Value 38 142.7 0.48 3.63E-06 106,000 53 Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected Not Detected 90% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx cant additive; antioxidant; stabilizer n plastics (HSDB); Disinfection by-Product Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS/BSA Notes BS = Biodegrades Slowly; BSA = Biodegrades Slowly with Acclimation ------- N-Nitrosodimethylamine (NDMA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 147 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosodimethylamine (NDMA) 2446 62759 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.000008 0.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect mmunological Includ ng Allergic - decrease in cellular immune response, Immunological Including Allergic - decrease in humoral mmune response, Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.00007 51 16 B2 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 1986 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.056 0.00069 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude , „ , 10 2 L' L Scores based on supplemental data HRL Ratio(s) NC HRL/CAL DHS 90%: 0.329 CAR HRL/CAL DHS 90%: 0.004 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year 37,351 ,1992 Supplemental Data IRIS (Vol. 17, Suppl. 7; 1987) CACART; RAIS; EPA; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosodimethylamine (NDMA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 148 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 409 585 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 87 0 Number of States % PWSs/Sites/Sam pies with detects 21.3 0 Units States States States Minimum value of Detects 0.001 Not Detected Non-cancer: 0.329 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 440 Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.009 Not Detected 90% of Detects 0.17 Not Detected Units for Mag data ug/L ug/L Cancer: 0.004 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwaterfPages/Chemicalconta minants.aspx ndustrial solvent; antioxidant; formerly in the production of rocket fuel (HSDB); Disinfection by-Product Value 38 12 -0.57 1.82E-06 Soluble 52 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation @37°C ------- N-Nitroso-di-n-propylamine NDPA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 149 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitroso-di-n-propylamine (NDPA) 8798 621647 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0005 7 7 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.005 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude .,, „ 2 2 NL.-L, HRL Ratio(s) See also supplemental water data CAR HRL/STORET 90% : 0.00049 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS CACART; EPA; RAIS; OEHHA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitroso-di-n-propylamine NDPA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 150 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS STORE! HRL Ratios (HRL/STORET 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 506 n PWSs/Sites/Sa mples 127 1,309 Units Ibs/yr Ibs/yr Ibsfyr #with Detects 0 22 Number of States 0 2 % PWSs/Sites/Sam pies with detects 0 1.68 Units States States States Minimum value of Detects Not Detected 0.19 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected 20 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 10 90% of Detects Not Detected 10.24 Units ug/L ug/L Cancer: 0.00049 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Research chemical (HSDB); Disinfection by-Product? Value 38 130 1.36 5.38E-06 10,000 44 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation @37°C ------- N-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 151 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N-Nitrosodiphenylamine 3193 86306 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 20.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1966 Critical Effect Corneal opacities, epithelial hyperplasia of the bladder and decreased weight gain Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude ,,, 2 1 NL HRL Ratio(s) NC HRL/CAL DHS 90% : 1 .84 See also supplemental water data CAR HRL/CA|_ DH£. g()% . Q Og32 Notes Reference Dose Reference Dose Reference Dose Reference Dose; NC1 1979; Basis LOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 17-week oral study in rabbit; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/paae/vear 10(4). 60.1 966 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0049 0.009 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 IRIS Cited by OEHHA Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 140 7.1 Y/N Y/N ug/L ug/L CACART; EPA; OEHHA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- N-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 152 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 14 n PWSs/Sites/Sa mples 133 #with Detects Units Ibs/yr Ibs/yr Ibsfyr #with Detects 1 % Samples with detects Number of States 0 2 % PWSs/Sites/Sam pies with detects 0.75 Minimum value of Detects Units States States States Minimum value of Detects 76.2 Non-cancer: 1.84 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 76.2 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 76.2 90% of Detects 76.2 Units for Mag data ug/L Cancer: 0.0932 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Rubber and polymer additive; chemical reagent (HSDB); DBP Value 6,154 3.13 1.21E-06 35 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- N-Nitrosopyrrolidine (NPYR) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 153 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosopyrrolidine (NPYR) 10160 930552 Attribute Scores Potency Severity 7 8 Prevalence Magnitude HEALTH EFFECTS DATA1 See also supplemental water data Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.002 2.1 2.1 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 1986 1987 Liver Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.02 Y/N Y/N ug/L ug/L 3-model Categorical Prediction HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS CACART; EPA; OEHHA; RAIS; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosopyrrolidine (NPYR) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 154 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 27 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States % PWSs/Sites/Sam pies with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units ug/L Notes Cancer: Research chemical (HSDB) Value 38 19 -0.19 4.89E-08 1,000,000 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation @37°C ------- Norethindrone (19-Norethisteron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 155 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Norethindrone (19-Norethisterone) 2525 68224 Attribute Scores 3-model Categorical Prediction Potency Severity 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0167 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect The norethindrone abel indicates that if the drug is taken during the first trimester of pregnancy that the riskfor hypospadia in male offspring doubles. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification NTP Carcinogen Classification Reasonably antic carcinogenic mg/L (mg/kg-d)-1 (mg/kg-d)-1 Dated to be Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.04 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 4 HRL Ratio(s) NC HRL/Kolpin MAX: 0.0459 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Daily Dose (MRDD) NTP 1 1th Report on Carcinogens; no quantificatio of dose-response CACART UMD, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Norethindrone (19-Norethisteron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 156 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, et al., 2002 HRL Ratios (HRL/Kolpin MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 70 Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 12.8 Units States States States Minimum value of Detects Non-cancer: 0.0459 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.872 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.048 90% of Detects Units for Mag data ug/L Notes National Surface Water Reconnaissance; Kolpin, etal., 2002. Env. Sci.&Technol., 36(6), pp. 1202-1211. Cancer: Value 60 2.97 5.80E-10 7.04 12 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- n-Propylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 157 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): n-Propylbenzene 4328 103651 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2.5 6,040 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - changes in spleen Behavioral - somnolence (general depressed activity) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5.83 Y/N Y/N ug/L ug/L Prevalence Magnitude 4 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 1.21 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVQH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Qalogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. Volume(issue)/page/year -,167,1990; 24 week oral study in rat Supplemental Data Rats; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year 2,327,1964 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- n-Propylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 158 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,724 22,970 42 54 0.33 0.24 0.03 0.1 34 21 0.7 0.6 4.8 4 34 21 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released # PWSs/Sites sampled 53 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1.23 Number of States % PWSs/Sites with detects 0.004 Units States States States Minimum value of Detects Non-cancer: 1.21 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 47 Year Maximum value of Detects 0.024 5 47 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Manufacture of methylstyrene; text le dyeing; printing solvent; asphalt and naphtha constituent (HSDB) Value 15 495-955 3.69 1.05E-02 23.4 22 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- o-Toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 159 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): o-Toluidine 3768 95534 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 340 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Kidney, Ureter, Bladder - proteinuria, Blood - normocytic anemia, Nutritional and Gross Metabol c - weight loss or decreased weight ga n. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.24 0.18 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 2000 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 793 0.194 Y/N Y/N ug/L ug/L Teratogen list Prevalence Magnitude , „ , 7 5 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VINIT Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Vo ume(issue)/page Supplemental Data HEAST Vol. 77; 2000 IARC, RAIS, OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 160 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 5 10,774 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 9 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Intermediate in the manufacture of dyes, rubber, Pharmaceuticals and pesticides (HSDB) Value 74.04 1.32 1.98E-06 16,600 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Oxirane, methyl- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 161 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Oxirane, methyl- 2661 75569 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 26 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect ncreased combined incidence of hyperkeratosis, hyperplasia and papillomas. Brain and Coverings - other degeneratve changes, Liver - other changes, Blood - other changes Cancer Data EPA Lifetime Cancer Risk, 10"* OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.15 0.24 0.24 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1990 1994 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 60.7 0.233 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 10 8 HRL Ratio(s) No water data Notes Reference Dose; Basis = BMDL „ 1 .4 mg/kg-d; UF = 1 000. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 45-day study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 46(7), 76,1 981 Supplemental Data CACART; RAIS; OEHHA; EPA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Oxirane, methyl- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 162 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 28,761 433,536 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 5 28 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (NTP) Value 2.324 0.03 6.98E-05 590,000 44 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BS Notes PBT; BS = biodegrades slow ------- Oxydemeton-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 163 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Oxydemeton-methyl 6458 301122 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00013 0.0025 10 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect Decreased erythrocyte & brain ChE Decreased body weight Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.91 Y/N Y/N ug/L ug/L male, female Prevalence Magnitude 95 Li HRL Ratio(s) NC HRL/SWC EEC: 1.01 Notes Reference Dose; Basis = NOAEL 0.013 mgfkg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 85JDAH "Organophosphorus Pesticides Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974 Volume(issue)/page/year -,197,1974 CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Oxydemeton-methyl CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 164 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 154,227 0 0 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 19 0 0 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Surface water chronic: 0.9 ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.006 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1.01 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value -0.74 1.62E-13 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS =Biodegrades Slowly ------- Oxyfluorfen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 165 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Oxyfluorfen 34731 42874033 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect ncr. abs. liver weight; nonneoplastic lesions Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0732 C mg/L (mg/kg-d)-' (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 21 0.478 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 6 Li L HRL Ratio(s) NC HRL/SWC EEC: 3.0 CAR HRL/SWC EEC: 0.067 Notes Reference Dose Reference Dose; Basis = NOEL 0.3 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year 9,643,1991 EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Oxyfluorfen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 166 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 705,255 0 5 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 37 0 2 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Surface water chronic: 7.1 ug/L Non-cancer: 3.0 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.08 ug/L Cancer: 0.067 Pesticide; herbicide Value 46,800 4.73 8.23E-07 0.116 5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant; PBT ------- Perchlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 167 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Perchlorate 24310 14797730 Attribute Scores 3-model Categorical Prediction Potency Severity 6 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0007 6 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d ug/L mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 2000 Critical Effect Radioactive iodide uptake inhibition (RAIU) in the thyroid Decreased newborn TSH Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification See notes mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-lnterimHA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 15 4.9 Y/N Y/N ug/L ug/L ug/L Teratogen Prevalence Magnitude .,, „ 9 8 NL!'L! HRL Ratio(s) NCHRL/UCMR90%: 0.35 Notes Reference Dose Reference Dose; Basis NOEL 0.007mg/kg-d Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Brechner et al. 2000 No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and species differences in thyroid function (IRIS). UMD Interim Health Advisory; EPA is revisiting the intermin hHealth Advisory for perchlorate. The HRL for the CCL differs from the Interim HA based on the RSC used in the health advisory (0.62) and the default RSC (0.2) used for the CCL process. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perchlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 168 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,554 147 4.14 4 420 6.5 14 59 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.35 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Smokeless rocket and jet propellant; explosives; analytical chemistry, etch ng and engraving agent (HSDB) Value 200,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes All use and env. fate data are for ammonium perchlorate. ------- Perfluorooctane sulfonic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 169 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Perfluorooctane sulfonic acid (PFOS) 12176 1763231 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL EPA/FR NOAEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.03 251 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Reduced F2 Body Weight Decreased body weights, increased liver weights, lowered serum total cholesterol, lowered triiodothyronine (T3) concentration, and lowered estradiol levels Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-Provisional HA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.2 0.2 Y/N Y/N ug/L ug/L ug/L January 2008 Prevalence Magnitude , „ , 10 7 L' L HRL Ratio(s) NC HRL/MN MW MAX: 0.143 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level No Observed Adverse Effect Level in 2 generation reproductive study in rats. Supplemental Data - FR October 18, 2000 (Volume 65, Number 202)] Perfluorooctyl Sulfonates; Proposed Significant New Use Rule [Page 6231 9-62333] Supplemental Data - Seacat et al., 2002, Toxicol. Sci. 68, 249-264. EPA Provisional HA: http://www.epa.gOV/waterscience/criteria/d rinkinglpha-PFOA_PFOS.pdf Lowest Observed Adverse Effect Level Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). The HRL was calculated in a d fferent manner than EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to derive the provisional HA. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perfluorooctane sulfonic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 170 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Select New Jersey Water Systems Select Minnesota municipal wells Select Minnesota non-community wells Select Minnesota private wells Aggregate of above Minnesota wells HRL Ratios (HRL/MN MW MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 37 22 26 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 13 6 0 0 6 Number of States % PWSs/Sites/Sam pies with detects 57% 16.2% 0% 0% 7.1% Units States States States Range of Detects (ug/L) 0.0042-0.019 ND-1.4 ND ND ND-1.4 Non-cancer: 0.143 Amount Range 10-500K 0 Units Ibs/yr Ibs/yr Year 2002 2003 (EPA est.) Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Notes Targeted Sampl ng 2006 - Targeted study "Determination of Perfluorooctanoic Acid (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water Supply. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Cancer: Estimate of zero as phased out. Surface-active agents in aqueous media; chemical intermediate; in fire-fight ng applications, floor polish; metal plating baths; pest c de active ingred ent for ant bait traps. (HSDB) Value 100,000 370 Units length of time L/kg unitless cm3/g atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant ------- Perfluorooctanoic acid (PFOA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 171 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Perfluorooctanoic acid (PFOA) 6614 335671 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.46 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 Critical Effect Increased maternal liver weight at term Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-Provisional HA Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 1.1 Y/N Y/N ug/L ug/L ug/L January 2008 Prevalence Magnitude 10 6 Scores based on supplemental data HRL Ratio(s) NC HRL/MN MW MAX: 1.22 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (BMDL10), Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA: http://www.epa.goV/waterscience/criteria/d rinking/pha-PFOA_PFOS.pdf Provisional Health Advisory: http://www.epa. gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf Note: HRL is based on adult exposure factors (70 kg body weight and 2 L/d ingestion). This value differs from EPA's provisional HA because child exposure factors and toxicokinetic adjustments were used to derive the provisional HA. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Perfluorooctanoic acid (PFOA) CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 172 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data NJDEP - Jan 2007 Little Hocking, OH Municipal Wells (FW) Select Minnesota municipal wells Select Minnesota non-community wells Select Minnesota private wells Aggregate of above Minnesota wells HRL Ratios (HRL/MN MW MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 No data 37 22 26 85 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 18 6 0 1 7 Number of States % PWSs/Sites/Sam pies with detects 78 16.2% 0% 3.8% 8.2% Units States States States Range of Detects (ug/L) <0.004 - 0.039 1.5-7.2 ND-0.9 ND ND-0.67 ND-0.9 Non-cancer: 1.22 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Notes Targeted study ' Determination of Perfluorooctanoic Ac d (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water Supply. Emmett, et al., 2006. J. Occ. Env. Med. Little Hocking, OH; data from 2002-2005. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampl ng 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Cancer: Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire-fight ng applications, cosmetics, greases and lubricants, pa nts, polishes and adhesives (HSDB) Value 180 27,000 9.10E-02 1 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Permethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 173 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Permethrin 35815 52645531 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.25 0.05 0.05 0.2 0.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1999 Critical Effect Neurotox (aggression, abnormal/ decreased movement), increased body temperature. Q1* 0.0096 (mg/kg/day)-1. See CAR ncreased liver weight Neurol. Cancer Data EPA Lifetime Cancer Risk, 10"* OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0096 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,750 3.65 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 7 Li L HRL Ratio(s) NC HRL/SWC EEC: 1,944 CAR HRL/SWC EEC: 4.05 Notes Reference Dose; Basis = NOAEL 25 mg/kg-d; UF = 100. Reference Dose; Basis = NOEL 5 mg/kd-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level; ATSDR MRL-int. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Permethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 174 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 1,066,056 0 17,979 Units Ibsfyr Ibs/yr Ibs/yr Number of States 48 0 7 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 0.9 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 1,944 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 4.05 nsecticide (HSDB) Value 178,000 6.5 1.87E-06 0.006 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF/BST Notes BF = biodegrades fast; BST = biodegrades sometimes/reca c trant ------- Profenofos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 175 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Profenofos 34318 41198087 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.0004 0.05 162 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Inhibition of plasma & RBC ChE activity Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Behavioral - somnolence (general depressed activity), Behavioral - tremor, Gastrointestinal - changes in structure or function of salivary glands Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N ug/L ug/L Prevalence Magnitude 86 Li HRL Ratio(s) NC HRL/SWC EEC: 3.5 Notes Reference Dose; Basis = NOEL 0.005 mg*g-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 12,781,1987 Supplemental Data TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 73,16,1984 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Profenofos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 176 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 879,776 0 255 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 14 0 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Surface water chronic: 0.1 ug/L Non-cancer: 3.5 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0.03 ug/L Cancer: Pesticide, insecticide, acaricide (HSDB) Value 4.68 2.21 E-08 28 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant; PBT ------- Quinoline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 177 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Quinoline 3467 91225 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.001 3 B2 mg/L (mg/kg-d)-1 (mg/kg-d)"1 2001 2001 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.01 Y/N Y/N ug/L ug/L 3-model Categorical Prediction L?-L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS IRIS Hirao et al., 1976; oral study in rats CACART, EPA, RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Quinoline CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 178 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 62 28,629 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 8 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; pharmaceutical (anti-malarial); flavoring (HSDB) Value 1,837 2.03 1.67E-06 6,110 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- RDX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 179 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): RDX 5404 121824 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 0.003 0.03 40 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2006 6/1995 Critical Effect nflammation of the prostate. Cardiac - other changes, Blood - pigmented or nucleated red blood cells, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.03 0.11 c mg/L (mg/kg-d)-1 (mg/kg-d)-1 1988 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 21 0.3 Y/N Y/N mg/L ug/L ug/L 2006 Teratogen Prevalence Magnitude 5 5 Li HRL Ratio(s) NCHRL/STORET90%: 0.092 CARHRL/STORET90%: 0.0013 Notes Reference Dose Reference Dose; Basis NOEL 0.3 mg/kg-d. U.S. DOD, 1983 Reference Dose Reference Dose Int-Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year AD-A092-531 Supplemental Data EPAHA EPA; RAIS UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- RDX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 180 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental water data STORE! HRL Ratios (HRL/STORET 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 23 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 23 Number of States % PWSs/Sites/Sam pies with detects 100 Units States States States Minimum value of Detects 15 Non-cancer: 0.092 Amount Range >500K - 1 M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 270 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 140 90% of Detects 229 Units ug/L Cancer: 0.0013 Notes High explosive Value 195.4 0.87 6.30E-08 59.7 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = biodegrades fast with acclimation ------- sec-Butyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 181 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): sec-Butylbenzene 5904 135988 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4.42 2,240 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -alteration of classical conditioning Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 10.3 Y/N Y/N ug/L ug/L Prevalence Magnitude 3 6 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 1.03 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 24-week oral rat study; VCVGH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated hydrocarbons) Bandman A.L. etal., Chimia, 1990. Volume(issueXpage/year -,179,1990 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- sec-Butyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 182 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,343 22,974 28 34 0.227 0.148 0.03 0.1 19.8 22 0.7 0.6 10 4.6 19.8 22 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 Amount Released # PWSs/Sites sampled 25 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0.58 Number of States % PWSs/Sites with detects 0.005 Units States States States Minimum value of Detects Non-cancer: 1.03 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 11 Year Maximum value of Detects 0.39 2.81 11 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent for coating compositions, organic synthesis, plasticizer, and surface active agents (HSDB) Value 15 7,200 4.57 1.80E-02 17.6 15 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = biodegrades slowly ------- Strontium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 183 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Strontium 18848 7440246 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 0.6 0.6 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2006 2004 Critical Effect Rachitic bone Musculo-skeletal effects Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 20 4,200 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 10 10 Li HRL Ratio(s) NCHRL/NIRS90%:3.88 Notes Reference Dose Reference Dose; Storey, 1961 ; Marie et al., 1985; Skoryna, 1981; UF = 300; Rat; Basis NOAEL = 190 mg/kg-d Reference Dose Reference Dose; IRIS Minimal Risk Level; UF = 30; MRL-Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Strontium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 184 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 980 99.1 1.5 43,550 178 1,080 7,340 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 3.88 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for strontium carbonate: In pyrotechnics; steel production; catalyst; lead scavenger (HSDB); naturally-occurring Value 11 Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for strontium carbonate; BST = biodegrades sometimes/recalcitrant ------- Tebuconazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 185 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Tebuconazole 69191 107534963 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.029 0.03 1,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2008 1994 Critical Effect Decreased body weights, absolute brain weights, brain measurements and motor activity in offspring Behavioral - food intake (animal) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)-1 2008 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 96 L' L HRL Ratio(s) NC HRL/GWC EEC: 9.09 Notes Reference Dose; Basis = LOAEL 8.8 mg/kg-d; UF = 300. Federal Register: May 14, 2008 (Volume 74, Number 94), pp 27748-27756. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Oral study- rabbit; NTIS Nationa Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0545183 OPP; 73 FR No. 94, pp 27748-27756. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tebuconazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 186 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 478,568 Units Ibs/yr Ibs/yr Ibs/yr Number of States 16 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 14 ug/L Ground water chronic: 23.1 ug/L HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 9.09 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Fungicide (HSDB) Value 3.7 1.45E-10 36 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Tebufenozide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 187 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Tebufenozide 69514 112410238 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.018 0.02 8.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 2003 Critical Effect Growth retardation, alterations in hematology parameters, changes in organ weights, and histopathological lesions in the bone, spleen and liver Effect on erythrocytes, periferal hemolytic anaemia. Gross and histopathologica lesions in the spleen (congestion, pigment, and extra-medullary haematopoiesis) Blood - normocytic anemia, Blood - thrombocytopenia Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 126 Y/N Y/N ug/L ug/L Prevalence Magnitude 9 5 Li HRL Ratio(s) NC HRL/SWC EEC: 8.4 Notes Reference Dose; Basis NOAEL = 1 .8 mg/kg-d, UF = 100. Federal Register 64 FR, No. 203, pp 56690-56697, October 21, 1999. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year study in dog; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 64, 16851, 1999 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tebufenozide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 188 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 104,413 Units Ibsfyr Ibs/yr Ibs/yr Number of States 17 Units States States States Year 1997 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 15 ug/L Ground water chronic: 1.19ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.4 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide (HSDB) Value 4.25 1.26E-08 0.83 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes PBT; BST = biodegrades sometimes/recalcitrant ------- Tellurium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 189 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Tellurium 23035 13494809 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 25 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Maternal toxicity Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 175 Y/N Y/N ug/L ug/L Teratogen Prevalence Magnitude 49 Li HRL Ratio(s) NCHRL/NIRS 90%: 0.673 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; No Observed Effect Leve ; Johnson et al., 1988 Lowest Observed Adverse Effect Level Supplemental Data Mouse; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of Internatonal Projects, GKNT, 1982 Volume(issue)/page/year - ,107,1982 UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tellurium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 190 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 4 0.4 15 370 22 260 360 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.673 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for sodium tellurite: Bacteriology, medicine (HSDB); naturally-occurring Value Units length of time L/kg unitless L/kg unitless mg/L Degradation Code BST Notes assume persistent; All use and env. fate data are for sodium tellurite; BST = biodegrades sometimes/recalcitrant ------- Terbufos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 191 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Terbufos 22585 13071799 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic? NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.00005 0.000025 0.0002 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 1989 Critical Effect Plasma ChE inhibition Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 1988 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.002 0.35 Y/N Y/N mg/L ug/L ug/L 2006 Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQA 90% : 1.67 Notes Reference Dose; Basis = NOAEL 0.005 mgrtsg-d; UF = 100. Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Terbufos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 192 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water CAL DHS STORE! HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T,,2, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released 6,515,603 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 61 915 22 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 #with Detects 0 11 0.31 Number of States 37 % PWSs/Sites/Sam pies with detects 0 0 % PWSs/Sites/Sam pies with detects 0 1.2 0.0021 Units States States States Minimum value of Detects Minimum value of Detects 0.1 Non-cancer: 1.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.56 Year 1997 Maximum value of Detects Not Detected Not Detected Maximum value of Detects 3.2 0.017 0.21 0.56 Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 0.185 95% of Detects Not Detected Not Detected 90% of Detects 0.202 Notes ug/L ug/L Units for Mag data ug/L ug/L Cancer: Pesticide Pilot Mentoring Program (USGS/EPA) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx nsecticide (HSDB) Value 38 500-5,000 4.48 2.40E-05 5.07 14 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = biodegrades slowly with acclimation ------- Terbufos sulfone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 193 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Terbufos sulfone 37071 5607016 Attribute Scores Potency Severity 7 3 Prevalence Magnitude 1 1 Scores based on parent Scores based on parent HEALTH EFFECTS DATA1 - See parent Terbufos Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma ChE inhibition Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N ug/L ug/L 3-model Categorical Prediction NL HRL Ratio(s) NC HRL/NAWQA 90% : 1 .67 (NAWQA data and HRL for parent terbufos) Notes Reference Dose - FOR PARENT TERBUFOS Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level Based on data for parent terbufos 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Terbufos sulfone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 194 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Finished Water Occurrence Data FOR TERBUFOS - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 0 0 Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data FOR TERBUFOS - PARENT N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data FOR TERBUFOS - PARENT CAL DHS STORE! PPMP finished water PPMP ambient water HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 Amount Released n PWSs/Sites/Sa mples 61 915 22 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 11 2 0 0.31 Number of States % PWSs/Sites/Sam pies with detects 0 1.2 0.9 0 0.0021 Units States States States Minimum value of Detects 0.1 Non-cancer: 1.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.56 Year Maximum value of Detects 3.2 0.016 0.017 0.21 0.56 Units for Mag data ug/L mg/L mg/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.185 90% of Detects 0.202 Units for Mag No(es data ug/L ug/L ug/L ug/L Cancer: Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O- ANALOGUE SULFONE Pesticide Pilot Montoring Program (USGS/EPA) FROM TERBUFOS O- ANALOGUE SULFONE NAWQA data and HRL for Parent Terbufos Pesticide degradate Value 38 2.21 E-08 21 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with ace mation ------- Thiodicarb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 195 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Thiodicarb 38116 59669260 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 2000 Critical Effect Extramedulary hematapoesis and decreased red blood cell cholinesterase activity Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0188 B2 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 1.86 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 6 L' L HRL Ratio(s) NC HRL/SWC EEC: 8.1 CAR HRL/SWC EEC: 0.07 Notes Reference Dose; Basis NOEL = 3.3 mg/kg-d (males) and 4.5 mg/kg-d (females); UF = 100; chronic rat study. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data CACART; EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiodicarb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 196 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 821,267 0.05 1,430 Units Ibsfyr Ibs/yr Ibs/yr Number of States 27 1 3 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 26 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.1 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.07 nsecticide (HSDB) Value 1.7 9.33E-07 35 36 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Thiophanate-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 197 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Thiophanate-methyl 27753 23564058 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.08 0.08 0.08 0.08 1.2 2,270 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2004 1986 1998 Critical Effect Thyroid and liver effects and decreased body weight Decreased body weight, decreased spermatogenesis and histological evidence of hyperthyroidism Endocrine - evidence of thyroid hypofunction, Endocrine - changes in thyroid weight, Nutritional and Gross Metabolic - weight loss or decreased weight gain Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation), Behavioral - somno ence (general depressed activity), Behavioral - convulsions or effect on seizure threshold Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0116 C mg/L (mgftg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 560 3.02 Y/N Y/N ug/L ug/L Female & male reproductive toxicity Prevalence Magnitude , „ , 10 6 Li L HRL Ratio(s) NC HRL/SWC EEC: 45.9 CAR HRL/SWC EEC: 0.248 Notes Reference Dose; Basis NOEL = 8 mg/kg-d; UF = 100; chronic dog study. Reference Dose; Basis = NOEL 8 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 67,14944,2002 Supplemental Data TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 23,606,1972 OPP EPA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiophanate-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 198 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 453,792 0 92 Units Ibsfyr Ibs/yr Ibs/yr Number of States 40 0 3 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 12.2 ug/L Ground water chronic: 3.03 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 45.9 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.248 Fungicide (HSDB) Value 14.32 1.4 2.94E-13 438.9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = biodegrades fast ------- Toluene diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 199 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Toluene diisocyanate 29421 26471625 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD501 CTDJPN Lowest Oral LD501 RTECS Lowest Oral LD501 Value 30 85.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Burns throat immediately. Related to Chronic Data - death Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.039 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 0.9 Y/N Y/N ug/L ug/L Prevalence Magnitude , 10 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-251,1986 Supplemental Data Applies to m ixture of 2,4- and 2,6- isomers. CACART; IARC; OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Toluene diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 200 of 1124 OCCURRENCE DATA # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 1 129,143 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 1 31 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M - 1 B >500M - 1 B Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n plastics manufacture (NTP) Value 9,114 3.74 1.11E-05 37.57 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Tribufos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 201 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Tribufos 2814 78488 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.00003 0.00003 4.08 77 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Plasma ChE inhibition Gastrointestinal - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - peptidases Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N ug/L ug/L Prevalence Magnitude 98 Li HRL Ratio(s) NC HRL/SWC EEC: 3.89 Notes Reference Dose; Basis = NOAEL 0.1 mg/kg-d; UF = 100. Reference Dose; Basis NOAEL 0.1 mg/kg-d; Abou-Donia etal., 1979 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 43 week study in rodent; FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year 38,96,1975 Supplemental Data 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,1188,1986 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tribufos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 202 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 4,918,265 4 7 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 16 1 1 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 2004 2004 Maximum value of Detects Surface water chronic 1.8ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 3.89 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: nsecticide; cotton defoliant (HSDB) Value 1,888 5.7 2.94E-07 2.3 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BF Notes BF = biodegrades fast ------- Triethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 203 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Triethylamine 5379 121448 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1 460 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Brain and Coverings - other degenerative changes Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2.33 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 9 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-week oral rat study; WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Du ixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987 Volume(issue)/page/year 4,45,1990 Supplemental Data AMIHBCAMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(ssue)/page/year 4,119,1951 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Triethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 204 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 12,000 1,167,219 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 14 35 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; stabilizer; in herbicides/pest c des; in consumer products; food addit ve; photographic chemical; in carpet c eaners (HSDB) Value 107.2 1.45 1.49E-04 73,700 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = biodegrades slowly with acclimation ------- Triphenyltin hydroxide (TPTH) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 205 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Triphenyltin hydroxide (TPTH) 2738 76879 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0003 0.0005 0.15 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1970 Critical Effect Decreased white blood cells Blood - changes in other cell count (unspecified), Blood - changes in leukocyte (WBC) count Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 18.3 B2 mg/L (mg/kg-d)-' (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 2.1 0.0019 Y/N Y/N ug/L ug/L Teratogen; Developmental Prevalence Magnitude 10 6 HRL Ratio(s) NC HRL/SWC EEC: 0.33 CAR HRL/SWC EEC: 0.0003 Notes Reference Dose; OPP RED Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day study in guinea pig; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year4,35,1966 Supplemental Data EPA; CACART UMD; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Triphenyltin hydroxide (TPTH) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 206 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 660,971 0 0 Units Ibsfyr Ibs/yr Ibs/yr Number of States 26 0 0 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic 6.4 ug/L Ground water chronic 0 ug/L Notes HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 0.33 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.0003 Pesticide (NTP) Value 2,000 3.53 4.26E-07 0.4 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Urethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 207 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Urethane 2189 51796 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.9 78 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2005 Critical Effect Decreased survival Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in leukocyte (WBC) count Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 1 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 6.3 0.035 Y/N Y/N ug/L ug/L Developmental Teratogen Prevalence Magnitude , 7 6 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Food and Chemical Toxicology 43 (2005) 1-19 Lowest Observed Adverse Effect Level; 1 3 week oral study in rats; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NIH-96- 3937 Supplemental Data Vol. 7, Suppl. 7; 1987 IARC; CACART; OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Urethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 208 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 96,050 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 0 7 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Paint ingredient (NTP) Value -0.15 6.40E-08 480,000 40 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- Vanadium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 209 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Vanadium 18882 7440622 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.007 0.003 1.8 960 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 2001 Critical Effect Minor renal effects (altered renal function as indicated by increased plasma urea, and mild histological changes). Kidney lesions and increases in plasma urea and uric acid Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21 Y/N Y/N ug/L ug/L Prevalence Magnitude , „ , 10 8 Li L HRL Ratio(s) NCHRL/NIRS90%:0.913 Notes Reference Dose Reference Dose Reference Dose Reference Dose; HEAST Minimal Risk Level; MRL-Int; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; IOM 2001 Dietary Reference ntakes No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; Domestic mammal Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vanadium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 210 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 146 14.76 3.1 70.4 7.27 23 45 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: 0.913 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for vanadium pentoxide: Chemical intermediate; catalyst; (HSDB); naturally-occurring Value 8,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; All use and env. fate data are for vanad um pentoxide; BST = biodegrades sometimes/recalcitrant ------- Vinclozolin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 211 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Vinclozolin 35005 50471448 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.012 0.025 0.025 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1995 Critical Effect Histopathological les ons in the lungs, iver, ovaries & eyes. Q1 * 0.0638 (mg/kg-day)-1 .Group C. See CAR Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor (oral) RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0638 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 84 0.549 Y/N Y/N ug/L ug/L Developmental Prevalence Magnitude , „ , 10 5 L' L HRL Ratio(s) NC HRL/SWC EEC: 8.94 CAR HRL/SWC EEC: 0.058 Notes Reference Dose; Basis = NOAEL 1 .2 mg/kg-d; UF = 1 00. Reference Dose; Basis = NOEL 2.5 mg/kg-d; UF = 100. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data EPA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vinclozolin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 212 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 121,959 0 0 Units Ibsfyr Ibs/yr Ibs/yr Number of States 26 0 0 Units States States States Year 1997 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration Surface water chronic: 9.4 ug/L Ground water chronic: 0 ug/L HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: 8.94 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: 0.058 Fungicide (HSDB) Value 289 3.1 1.33E-08 2.6 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = biodegrades sometimes/recalcitrant ------- Ziram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 213 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ziram 5947 137304 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.016 0.003 1.6 1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Decreased body weight gain Decreased body weight Gastrointestinal - hypermotility, diarrhea Cancer Data EPA Lifetime Cancer Risk, 104 OPP Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0611 Suggestive (not quantified) 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 112 0.57 Y/N Y/N ug/L ug/L Prevalence Magnitude , 10 7 L HRL Ratio(s) NC HRL/SWC EEC: 56.6 CAR HRL/SWC EEC: 0.288 Notes Reference Dose; Basis = NOAEL 1 .6 mg/kg-d; UF = 1 00. Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake; Group ADI for Ferbam and Ziram Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level OPP Lowest Observed Adverse Effect Level; NNG ADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 1 70, Japan) V.1- 1976- Volume(issue)/page/year 17,3155,1992 Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ziram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 214 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Amount Released 1,992,552 Units Ibsfyr Ibs/yr Ibs/yr Number of States 29 Units States States States Year Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Surface water chronic: 1 .98 ug/L Non-cancer: 56.6 Amount Range >500K - 1 M >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 Ground water chronic: 0.03 ug/L Cancer: 0.288 Synthetic rubber chemical (NTP); fungicide Value 6.20E-10 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades Fast with Acclimation ------- (d)-Limonene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 215 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): (d)-Limonene 17273 5989275 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI IPCS-CICAD TDI CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 500 30 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect ncreased relative liver weight Decreased body weight gain Kidney, Ureter, Bladder - other changes in urine composition, Kidney, Ureter, Bladder - other changes Prevalence Magnitude 9 6 NLi HRL Ratio(s) NC HRL/NREC ASW MED: 700 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake IPCS Tolerable Daily Intake No Observed Effect Level Supplemental Data; NTP Study Report TR-347 Lowest Observed Adverse Effect Level; oral study in rat; FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year31,125,1993 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 700 Y/N Y/N ug/L ug/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- (d)-Limonene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 216 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NREC ASW MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects 6.39 1.47 Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 700 Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 1 0.39 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Used in flavorings, fragrances, cosmetics, as a solvent, wetting agent and the manufacture of resins, insecticide, synthetic intermediate (HSDB) Value 1,300 4.57 0.026 13.8 19 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes Biodegrades slow (PBT) ------- (Hydroxyimino)cyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 217 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): (Hydro xyiminojcyclohexane 4125 100641 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 17.86 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Endocrine - changes in spleen weight, Blood - changes in erythrocyte (RBC) count, Blood - changes in leukocyte (WBC) count Prevalence Magnitude 8 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue);pagefyear5,117,1985 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 41.7 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- (Hydroxyimino)cyclohexane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 218 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 0.84 8.05E-06 18,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1,1,1 -Trichloropropanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 219 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): 1 ,1 ,1 -Trichloropropanone 10061 918003 Attribute Scores Potency Severity Prevalence Magnitude 10 7 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction HRL Ratio(s) No HRL data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 ~6 cancer risk was used. ------- 1,1,1 -Trichloropropanone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 220 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water 53 16.97 1.7 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al., 2006 and related documentation HRL Ratios (no HRL data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples 12 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 10 Number of States % PWSs/Sites/ Samples w/ Detects 83 Units States States States Minimum value of Detects Not detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 7 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.8 90% of Detects Units for Mag data ug/L Notes Finished drinking water monitoring; Krasner, et al., 2006. Env. Sci. & Technol., 40(23), pp. 7175-7185 (and related documentation). Cancer: Disinfection By-Product Value 60 days 8.7 1.12 2.20E-06 7,450 48 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- 1,1,2,2-Tetrachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 221 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,1 ,2,2-Tetrachloroethane 2878 79345 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.06 0.04 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Decreased body weights; increased white blood cell counts, hepatic fat content and pituitary ACTH content Hepatocellular vacuo zation and increases in absolute and relative Prevalence Magnitude 5 6 NLi HRL Ratio(s) NC HRL/NCOD R1 90%: 0.13 Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis NOAEL rat, Microbioligica Associates, 1994. UF = 300 Minimal Risk Level; Basis LOAEL 43, rat, NCI 1 987; UF = 1 ,000 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.02 0.2 0.27 C 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.002 0.35 Y/N Y/N mg/L ug/L ug/L EPA; RAISHE; OEHHA; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,1,2,2-Tetrachloroethane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 222 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,407 24,800 91 19 0.446 0.0766 0.05 0.1 200 2 0.5 0.5 2.74 1.5 112 2 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,317 # Sam pies Amount Released 5 3,185 # PWSs/Sites/ Samples 134 3 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0.069 % Samples with detects Number of States 1 5 % PWSs/Sites/ Samples with detects 0 0.02 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.13 Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.38 Maximum value of Detects Year 2004 2004 Maximum value of Detects 0.14 Median value of Detects 0.38 90% of Detects 0.38 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 90% of Detects Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx ndustrial solvent; former pesticide; in manufacture of paints, varnish, rust removers; in soil sterilization and weed k Her, insecticide formulations; chemical intermediate (HSDB) Value >58 days 106.8 2.39 0.00037 2,870 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- 1,2,3,4-Tetrahydronapthalene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 223 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,2,3,4-Tetrahydronaphthalene 5285 119642 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,860 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg mg/kg mg/kg Date 1982 Critical Effect Cataract Prevalence Magnitude 7 3 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Ref: Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London: Williams and Wilkins 1982., p.122 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2,3,4-Tetrahydronapthalene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 224 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; paint remover; nsecticide (HSDB) Value 1,800 0.0017 23 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) PBT ------- 1,2,3-Trichlorobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 225 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,2,3-Trichlorobenzene 3257 87616 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0015 7.7 77.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg(kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 1988 Critical Effect Mild to moderate histopathological changes in the liver, thyroid and Wdney Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 5 6 NLi HRL Ratio(s) NC HRL/NCOD R1 90%: 18 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; ITER. Ref: HC2004. Basis NOEL, rat, Cote, etal., 1988. UF =5000 Lowest Observed Adverse Effect Level; oral study in rat; DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year 11,11,1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 53.9 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,2,3-Trichlorobenzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 226 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,876 22,532 63 43 0.489 0.191 0.04 0.03 15 2.4 0.5 0.5 3 1.4 15 2.4 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 # Sam pies Amount Released # PWSs/Sites/ Samples 11,833 3 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 6 0.07 % Samples with detects Number of States % PWSs/Sites/ Sam pies with detects 0.05 0.02 Minimum value of Detects Units States States States Minimum value of Detects 0.6 Non-cancer: 18 Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.102 Maximum value of Detects Year 2004 2004 Maximum value of Detects 7 0.068 Median value of Detects 0.102 90% of Detects 0.102 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.7 90% of Detects 6.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx ndustrial solvent; chemical intermediate; termite control (HSDB) Value 2,500-63,000 4.05 0.0012 18 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- 1,2,4,5-Tetrachlorobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 227 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,2,4,5-Tetrachlorobenzene 3799 95943 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0003 0.003 0.00021 0.0432 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1992 1988 Critical Effect Kidney lesions Liver - changes in liver weight Prevalence Magnitude 5 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Basis NOAEL = 0.34, rat, Chu et al. 1984. UF = 1000 Reference Dose Reference Dose; Basis NOAEL, rat, Chu etal. 1984. UF = 1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; ITER. Basis NOAEL = 2.1 mg-kg/d, rat, NTP 1991. UF = 10,000 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in mouse; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB92-1 28388 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2.1 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2,4,5-Tetrachlorobenzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 228 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Chemical intermed ate for herbicides; former insectic Value 60 days 1,186 4.64 0.001 0.595 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes de (HSDB) Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- 1,2,4-Trimethyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 229 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,2,4-Trimethylbenzene 3775 95636 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 100 114 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect dec in body wt gain; clinical observations; inc iver/kidney wt Peripheral Nerve and Sensation - recording from afferent nerve, Peripheral Nerve and Sensation - recording from peripheral motor nerve, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 6 6 NLi HRL Ratio(s) NC HRL/NCOD R1 90%: 35 Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis NOAEL, rat, IITR1 1995. UF = 3000. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO191UD, UK) V.1- 1981- Volume(issue)/page/year 13,123,1993 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 350 Y/N Y/N ug/L ug/L 1987 EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2,4-Trimethyl benzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 230 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,755 22,968 106 177 0.831 0.771 0.02 0.1 77 137 1 0.8 10 5.6 65.6 70.6 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,233 # Sam pies Amount Released 5,676 7,700,757 # PWSs/Sites/ Samples 11,886 473 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 35 11.2 % Samples with detects Number of States 37 54 % PWSs/Sites/ Samples with detects 0.29 0.003 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Non-cancer: 350 Amount Range >50M-100M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 260 Maximum value of Detects Year 2004 2004 Maximum value of Detects 19 0.024 Median value of Detects 0.201 90% of Detects 10 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1 90% of Detects 5.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermed ate; vermifuge (HSDB) Value 718 3.63 0.0062 0.252 57 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- 1,2-Diphenylhydrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 231 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,2-Diphenylhydrazine 5454 122667 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude .,, .,, „ HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification 0.005 0.8 0.87 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 1986 IRIS Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.05 Y/N Y/N ug/L ug/L EPA; RAIS; OEHHA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2-Diphenylhydrazine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 232 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1C, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 5 # PWSs/Sites/ Samples 65 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 0 1 % PWSs/Sites/ Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermediate; evaluated as insecticide (HSDB) Value 3,481 2.94 4.38E-09 221 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades sow with acclimaton (BIODEG) ------- 1,2-Epoxy-4-(epoxyethyl)cyclohe CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 233 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1,2-Epoxy-4-(epoxyethyl)cyclohexane 4566 106876 Attribute Scores 3-model Categorical Prediction Potency Severity 8 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 1 7 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1994 Vol. 60; cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N ug/L ug/L IARC, CACART; Clear evidence of carcinogenicity in male and female rats and mice (NTP). Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,2-Epoxy-4-(epoxyethyl)cyclohe CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 234 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical and polymer intermediate (HSDB) Value 1 5 days 0.44 1.42E-07 35,200 42 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1,3-Cyclopentadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 235 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,3-Cyclopentadiene 7730 542927 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 113 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 8 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0535718 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7.91 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Cyclopentadiene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 236 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 89.7 2.25 0.00793 471 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1,3-Dibromo-5,5-dimethylhydanto CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 237 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1,3-Dibromo-5,5-dimethylhydantoin 2748 77485 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.437 250 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Endocrine - evidence of thyroid hypofunction Prevalence Magnitude 3 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; QISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volu me(issue)/page/year 36(1 0),1 08,1 971 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.02 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Dibromo-5,5-dimethylhydanto CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 238 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >500K-1 M Molluscicide; slim Value 38 days -0.94 51 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes cide (ChemlDPIus) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 1,3-Dichloropropene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 239 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,3-Dichloropropene 7722 542756 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 0.02 0.03 0.03 2.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Decreased body weight gain and increased incidence of basal cell hyperplasia of the nonglandular mucosa of the stomach forestomach chronic irritation Gastrointestinal - changes in structure or function of endocrine pancreas, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other hydrolases Prevalence Magnitude 4 6 Li HRL Ratio(s) NC HRL/NCOD R1 90%: 97.2 CAR HRL/NCOD R1 90%: 0.16 Notes Reference Dose; Stott, et al. 1995 Reference Dose, Stott etal., 1995, Basis BMD = 2.2 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose, Stott etal., 1995, BMDL/BMD, rat, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 39(1), 94,1 974 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) OPP Slope Factor EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.04 0.1 0.091 1.22 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 2000 1999 Vol. 41, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 WHODWQ Health Reference Level (HRL)2 cancer Y 1 175 20 0.287 Y/N Y/N mg/L ug/L ug/L ug/L EPA, RAISHE, OEHHA, OPP, IARC, CACART Drinking Water Equivalent Level Substance Guideline Value; For excess risk of 1 0-5 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Dichloropropene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 240 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 9,164 16,787 15 58 0.16 0.35 0.5 0.2 2.0 39.0 1.0 0.5 1.8 0.99 2.0 39.0 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 34,717,237 0 4,471 # PWSs/Sites/ Samples 12,117 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 4 % Samples with detects Number of States 20 0 9 % PWSs/Sites/ Sam pies with detects 0.03 Minimum value of Detects Units States States States Minimum value of Detects 0.86 Non-cancer: 97.2 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 130 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2.8 90% of Detects 92.1 Units for Mag data ug/L Cancer: 0.16 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx pesticide; in organic synthesis (HSDB) Value 38 days 80.8 2.03 0.00355 2,800 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 1,3-Diisopropyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 241 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,3-Diisopropylbenzene 4042 99627 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.25 3,100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - muscle contraction orspasticity, Behavioral - alteration of classical conditioning, Blood • changes in erythrocyte (RBC) count Prevalence Magnitude 5 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year36(9),18,1971 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.58 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,3-Diisopropyl benzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 242 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 38 4.9 2.00E-02 4.33 8 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 1,4-Benzoquinone dioxime CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 243 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,4-Benzoquinone dioxime 4434 105113 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5.94 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1964 Critical Effect Behavioral - alteration of classical conditioning, Nutritional and Gross Metabolic - weight loss or decreased weight gain, Biochemica - Enzyme inhibition, induction, or change in blood ortissue levels - true cholinesterase Prevalence Magnitude 3 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 29(10),15,1964 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol. 29, Suppl. 7; Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 13.9 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,4-Benzoquinone dioxime CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 244 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber additive (HSDB) Value 1 5 days 1.49 3.74E-10 4,550 29 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1,4-Butanediol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 245 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1,4-Butanediol 4866 110634 Attribute Scores 3-model Categorical Prediction Potency Severity 3 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.125 400 30 1,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1968 Critical Effect Reproductive and developmental toxicity Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase, Biochemical - Metabolism (Intermediary) - other carbohydrates Prevalence Magnitude .,,„,-, 9 5 NL-L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake; No severity information is available; Potency/Severity scored on CTDJPN NOEL. Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 33(1), 37,1 968 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,800 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,4-Butanediol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 246 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; humectant, Pharmaceuticals (HSDB) Value 18 1.30E-09 1,000,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- 1,4-Butynediol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 247 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1,4-Butynediol 4868 110656 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1968 1984 Critical Effect Blood -changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical -Enzyme inhibition, induction, or change in blood or tissue levels -true cholinesterase, Biochemical - Metabolism (Intermediary) - other carbohydrates Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year33(1),37,1968 Supplemental Data VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1 994. Volume(issue)/page/year -, 1 53, 1 984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4.67 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1,4-Butynediol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 248 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 8.7 days 1 -0.93 1.70E-11 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (PBT) ------- 1,4-Cyclohexanedimethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 249 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,4-Cyclohexanedimethanol 4431 105088 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mgflsg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 7 7 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data KODAK Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/pagefyear 21MAY1971 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,4-Cyclohexanedimethanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 250 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in films and coatings (HSDB) Value 15 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1,5,9-Cyclododecatriene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 251 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1 ,5,9-Cyclododecatriene 16316 4904614 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,780 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mgflsg Date Critical Effect Behavioral -tremor Prevalence Magnitude 7 5 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0557883 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1,5,9-Cyclododecatriene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 252 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Specialty petrochemical (NLM TOXNET) Value 15 5.5 4.99E-01 0.39 13 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 11-Aminoundecanoicacid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 253 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 11-Aminoundecanoic acid 13315 2432997 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 750 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Kidney, Ureter, Bladder -other changes Prevalence Magnitude 6 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-216,1982 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,750 Y/N Y/N ug/L ug/L IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 11-Aminoundecanoicacid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 254 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer initiator (HSDB) Value 15 -0.16 1,000 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 1-Amino-2,4-dibromoanthraquinon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 255 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Amino-2,4-dibromoanthraquinone 2996 81492 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 90 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - leukemia, Tumorigenic - active as anti-cancer agent Prevalence Magnitude 1 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB97-1 1 6636. 104-week rat study. Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Amino-2,4-dibromoanthraquinon CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 256 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate (HSDB) Value 60 days 18,000 5.31 1.78E-13 5 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- 1-Decanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 257 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Decanol 5018 112301 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4,720 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - somno ence (general depressed activity), Lungs, Thorax, or Respiration -dyspnea Prevalence Magnitude .,, .,, „ 7 3 NL-NL, HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issueypage/year 34,493,1973 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Decanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 258 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; chemica intermediate (HSDB) Value 7,300 4.57 3.20E-05 37 23 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 1-Dodecanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 259 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Dodecanol 5039 112538 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,170 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 7 3 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Sandman A.L. et al,, Ghimia, 1994. Volume(issue)/page/year -,1 19,1984 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Dodecanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 260 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; chemica intermediate; food additive (HSDB) Value 15,000 5.13 2.22E-05 4 16 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 1-Heptanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 261 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Heptanol 4965 111706 Attribute Scores 3-model Categorical Prediction Potency Severity 8 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 500 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Brain and Coverings - other degenerative changes, Liver - other changes, Kidney, Ureter, Bladder - other changes Prevalence Magnitude 3 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year -,113,1994 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.058 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 1-Heptanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 262 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent; cosmetic formulations; food additive (HSDB) Value 74 2.62 1.88E-05 1,670 28 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 1-Hexene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 263 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Hexene 8242 592416 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 Critical Effect Kidney, ureter, bladder, - changes in tubules including acute renal failure, acute tubilar necrosis Prevalence Magnitude 9 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year23,327,2000< LOAEL, rat Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,333 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Hexene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 264 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 8.7 days 1,660 3.39 0.41 50 78 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (PBT) ------- 1-Pentanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 265 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Pentanol 2564 71410 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data VCVQK "Vrednie chemichescie veshestva, galogen 1 kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Sandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,107,1984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Pentanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 266 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; synthetic flavor ng agent (HSDB) Value 4.51 1.51 1.30E-05 22,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 1-Propanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 267 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 1-Propanol 2560 71238 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 600 1,870 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1970 Critical Effect Endocrine - changes in adrenal weight Prevalence Magnitude 8 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; BIOFX BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbroolc, IL 60062) Volume(issue)/pagefyear 15-4/1970 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,400 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 1-Propanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 268 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units Cancer: Notes Solvent; chemica intermediate; former pesticide (HSDB) Value 33 0.25 7.41 E-06 1,000,000 46 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2-(Dimethylamino)ethyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 269 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-(Dimethylamino)ethyl acrylate 13333 2439352 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4 455 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Epithelial hyperplasia of the forestomach; hematological effects; decreased body weight gain. Lungs, Thorax, or Respiration - other changes Prevalence Magnitude 6 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data rat study; EPASR United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/paqe/year 8EHQ-1 190-1 1 1 9 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 28 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-(Dimethylamino)ethyl acrylate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 270 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial Chemical (EPA/SRS) Value 1 5 days 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2,3-Dibromopropanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 271 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,3-Dibromopropanol 3812 96139 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 681 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 1 7 Li HRL Ratio(s) No HRL/No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page;year OTS0528372 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N ug/L ug/L IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2,3-Dibromopropanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 272 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for flame retardants, insectic des, and pharmaceut cals (HSDB) Value 15 4 6.30E-08 52,000 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2,4,5-Trichlorophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 273 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4,5-Trichlorophenol 3800 95954 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 0.003 72 600 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 2000 1972 Critical Effect Liver & kidney pathology (degenerative changes) mmune system Liver - other changes, Liver - changes n liver weight Prevalence Magnitude .,, .,, „ HRL Ratio(s) No water data Notes Reference Dose Reference Dose; McCollisteret al., 1961. Basis NOEL 100, rat, UF = 1000 Reference Dose Reference Dose; McCollister et a ., 1961. Basis NOEL/LOEL, rat, UF = 1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Exon and Koller, 1985. Basis NOAEL, rat. Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in mouse; CMSHAF Chemosphere. (Pergamon Press nc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year 1,153,1972 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2,4,5-Trichlorophenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 274 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 4,689 18,879 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Fungicide, bacter Value 1,186 3.72 1.62E-06 1,200 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes cde; industrial preservative; chemical intermediate (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- 2,4,6-Trichlorophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 275 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4,6-Trichlorophenol 3282 88062 Attribute Scores 3-model Categorical Prediction Potency Severity 7 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0003 0.003 240 Units mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Increased pups liver weight mmune system Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Prevalence Magnitude 1 1 NL! HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose; EPA Health Advisory Reference Dose Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Exon and Koller, 1985. Basis NOAEL, rat. Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year 9(5), 497, 1990 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification 0.3 0.011 0.07 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL WHODWQ Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.01 200 2.1 Y/N Y/N mg/L mg/L ug/L ug/L 1994 EPA; RAISHE; OEHHA; IARC; CACART Drinking Water Equivalent Level World Health Organization Drinking Water Guideline Value 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2,4,6-Trichlorophenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 276 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 294 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 1,728 1,906 # PWSs/Sites/ Samples 210 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 3 3 % PWSs/Sites/ Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggragate Notes Median value of Detects 90% of Detects Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Fungicide, bactericide; industrial preservative; chem cal intermediate (HSDB) Value 1,186 3.69 2.59E-06 800 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (HSDB) ------- 2,4-Dimethylphenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 277 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4-Dimethylphenol 4471 105679 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 100 809 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1995 Critical Effect Clinical signs (lethargy, prostration, ataxia) & hematological changes Lethargy, prostration, ataxia, hematological changes Kidney, Ureter, Bladder - changes in kidney weight Prevalence Magnitude 8 7 Li HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose; U.S. EPA, 1989. Basis NOAEL 50, mouse. Reference Dose Reference Dose; U.S. EPA, 1989. Basis NOAEL/LOAEL, mouse, UF = 3000. Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; TOBHB TAT Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie Volume(issue)/page/year VI137, 1,1995 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,4-Dimethylphenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 278 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 1,137 168,992 # PWSs/Sites/ Samples 171 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 10 15 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx As a disinfectant/bacteriocide/germicide; chemical intermediate for Pharmaceuticals and pesticides; former insect c de/biocide (HSDB) Value 718 2.3 9.52E-07 7,870 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2,4-Dinitrophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 279 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4-Dinitropheno 2166 51285 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 10 0.0006 2 49 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1966 Critical Effect cataract formation in humans cataract formation Blood - other changes Prevalence Magnitude 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose; Horner, 1942. Basis LOAEL, human Reference Dose Reference Dose; Horner, 1942. Basis LOAEL, human, UF = 1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve ; oral study in rabbit; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year31(6),3,1966 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 14 Y/N Y/N ug/L ug/L teratogen UMD Drinking Water Equ valent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,4-Dinitrophenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 280 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 294 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1C, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 502 649 # PWSs/Sites/ Samples 134 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 3 % PWSs/Sites/ Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermediate; former pestcide (HSDB) Value 364 1.67 8.61 E-08 2,790 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- 2,4-Dinitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 281 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4-Dinitrotoluene 5365 121142 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 0.002 0.002 0.896 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 1998 1985 Critical Effect Neurotoxicity, hematological, and bilary effects Neurotoxicity, heinz bodies, and bilary tract hyperplasia Hematological Blood - normocytic anemia, Blood - methemoglobinemia- carboxyhemoglobin, Blood - changes in other cell count (unspecified) Prevalence Magnitude , „ , 1 10 Li L HRL Ratio(s) NC HRL/UCMR 90%: 0.042 CAR HRL/UCMR 90%: 0.00015 Notes Reference Dose Reference Dose; Ellis et al., 1985 Basis NOAEL 0.2, dog. Reference Dose Reference Dose; Ellis et al., 1985 Basis NOAEL, dog. UF = 100 Minimal Risk Level. Ellis etal., 1979, 1985 Basis NOAEL, dog. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in mouse; JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year 4(4), 257, 1985 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.005 0.68 0.31 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 EPAHA Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 14 0.05 Y/N Y/N mg/L ug/L ug/L Repro CACART; EPA; OEHHA; IARC CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,4-Dinitrotoluene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 282 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,621 1 0.028 333 333 333 333 333 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 14 6,702 # PWSs/Sites/ Samples 2,614 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 4 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: 0.042 Amount Range >500K-1M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: 0.00015 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermed ate; in propellants (HSDB) Value 364 1.98 5.41 E-08 270 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- 2,4-Toluenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 283 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,4-Toluenediamine 3790 95807 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 50 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Kidney, Ureter, Bladder - other changes, Related to Chronic Data - death Prevalence Magnitude 2 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; TAEHC Environmental Health Criteria (United Nations Environment Programme. Geneva, World Health Organization) 1- 1976- VolumefissueVoaae/vear -.1.1987 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3.2 3.8 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-' (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 117 0.0092 Y/N Y/N ug/L ug/L RAIS; OEHHA; EPA; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,4-Toluenediamine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 284 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 11,834 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in dyes and photographic developers (HSDB) Value 120 0.14 9.52E-10 74,800 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- 2,5-Xylenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 285 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,5-Xylenol 3795 95874 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 383 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1968 Critical Effect Behavioral - ataxia, Behavioral - muscle contraction or spasticity, Lungs, Thorax, or Respiration -dyspnea Prevalence Magnitude 6 5 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964- 71. Discontinued. Volume(issue)/page/year33(7-9), 329,1968. Mouse study. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,5-Xylenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 286 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Petroleum antiox dant; chemical intermediate (HSDB) Value 440 2.33 7.10E-06 3,540 29 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2,6-Dimethylphenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 287 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,6-Dimethylphenol 8028 576261 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0006 0.0006 0.6 6 296 Units mg/kg-d m g/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1968 Critical Effect Body weight & blood pressure changes; changes in protein sulfhydryl groups in blood serum & internal organs; histopatho ogical changes in liver, kidney & spleen. body weight changes, histopathological changes of internal organs Liver, kidney, spleen Liver - other changes, Blood - changes in spleen, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Prevalence Magnitude 8 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Veldre and Janes, 1979. Basis NOEL, rat Reference Dose Reference Dose; Veldre and Janes, 1979. Basis NOEL/LOEL, rat, UF = 1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; ITER; Veldre and Janes, 1979. Basis NOEL/LOEL, rat, UF = 1000 Lowest Observed Adverse Effect Level; oral study in rat; HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year 33(7- 9), 329,1968 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4.2 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,6-Dimethylphenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 288 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 733 2.36 6.66E-06 6,050 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- 2,6-Xylidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 289 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2,6-Xylidine 3258 87627 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 24 221 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Decreased survival and decreased body weights, deceases in red blood cell count, hemoglobin and hematocrit positive for cancer in male and female rats IVIice not tested. Brain and Coverings - changes in brain weight, Liver - changes in liver weight, Blood - changes in other cell count (unspecified) Prevalence Magnitude .,, „ 2 4 NL!'L! HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-278,1990 Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR- 278,1990 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 168 Y/N Y/N ug/L ug/L CACART; IARC; Note: Tested positive for cancer in male and female rats (NTP) Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2,6-Xylidine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 290 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,938 5,256 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; pesticide (HSDB) Value 52 1.84 2.50E-06 8,200 35 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST - Biodegrades sometimes/recalcitrant (PBT) ------- 2-Chloro-1-propanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 291 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Chloro-1-propanol 2842 78897 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 75 111 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Nutritional and Gross Metabolic - weight loss or decreased weight gain, Related to Chronic Data - death Details of toxic effects not reported other than lethal dose value. Prevalence Magnitude 9 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/paqe/year -,185,1994 Supplemental Data Clayton, QD.( FE. Clayton (eds). Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology 4th ed. New York, NY: John Wiley & Sons, Inc., 1993-1 994 p. 2736 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-Chloro-1-propanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 292 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1 B Units Ibs/yr Ibs/yr Year 1986 Maximum value of Detects Year Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 15 2 1.70E-06 43 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-Ethyl-3-propylacrolein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 293 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethyl-3-propylacrolein 9266 645625 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 7 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data JIHTABJourna of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume issue)/page/year 26,269, 1944 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethyl-3-propylacrolein CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 294 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for insecticides and other organics (HSDB) Value 15 70 24 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-Ethylhexanal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 295 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexana 5484 123057 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 7 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0534445, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethylhexanal CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 296 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; disinfectant (HSDB) Value 1 5 days 160 0.00076 400 25 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- 2-Ethylhexanoic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 297 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexanoic acid 6263 149575 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 61 629 3,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect increased liver weight, hepatocyrte hypertrophy cytoplamic vacuolization Behavioral - somnolence (general depressed activity), Liver - changes in liver weight, Skin and Appendages - hair Prevalence Magnitude 7 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Publication Juberg, et al., 1998 Lowest Observed Adverse Effect Level; oral study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0525547 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 427 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethylhexanoic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 298 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cosolvent and defoamer in pesticides; chemical intermediate (HSDB) Value 650 2.64 2.90E-06 1,400 28 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (BIODEG) ------- 2-Ethylhexanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 299 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexanol 4405 104767 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 125 100 2,053 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Decreased body weight, increased liver, kidney, stomach and testes weights, microscopic changes in the liver and forestomach Liver - other changes Prevalence Magnitude 9 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Publication Astill eral, 1996 Lowest Observed Adverse Effect Level; oral study in rat; VCVQK "Vrednie chemichescie veshestva, galogen I kislorod sodergashieorganicheskie soedinenia". (Hazardous substances. Halogen and oxygen containing substances), Bandman A.L. et al,, Chimia, 1994. Volume(issue)/page/year -,116,1994. The LOAEL was used for Potency scoring because it was lower than the NO(A)EL from other studies. Supplemental Data WHO: Environ Health Criteria Number 32: Toxicological Evaluation of Certain Food Additives and Contaminants. P. 39 (1993) Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 233 Y/N Y/N ug/L ug/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethylhexanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 300 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; plasticizer; wetting agent; dry cleaning (HSDB) Value 105 2.65E-05 880 2T Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2-Ethylhexenal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 301 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexena 29251 26266682 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Behavioral - altered sleep time, chages in motor activity, muscle contraction and spasticity (including change in righting reflex) Prevalence Magnitude .,, „ 8 5 NL!'L! HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data QTPZAB, rodent-rat; QTPZAB Qigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume issue)/page/year 32(3),48,1988 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethylhexenal CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 302 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1QOM-500M Units Ibs/yr Ibs/yr Year 1990 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 1 5 days 24 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- 2-Ethylhexyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 303 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexyl acrylate 4286 103117 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3 4,400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood ortissue levels - true cholinesterase Prevalence Magnitude 8 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; QISAAA Qigiena i Sanitariya. For English translation, see HYSAAV. (V/O MezhdunarodnayaKniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year -,16,1 993 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Ethylhexyl acrylate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 304 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes As monomer; in pa nts (HSDB) Value 15 430 4.09 0.00043 100 ir Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-Ethylhexyl thioglycolate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 305 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Ethylhexyl thioglycolate 19121 7659861 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 303 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 6 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year 20,575,1974) Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Leve 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- 2-Ethylhexyl thioglycolate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 306 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water FRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,E, Half life KQC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Year 1997 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggragate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Value 15 days 22 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- 2-Hydroxyethyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 307 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Hydroxyethyl acrylate 9783 818611 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Sense Organs and Special Senses (Eye) - ptosis, Behavioral - convulsions or effect on seizure threshold, Gastrointestinal -alteration in gastric secretion Prevalence Magnitude 6 5 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 24(4),56,1980 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Hydroxyethyl acrylate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 308 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Polymer intermec Value 18 -0.21 7.20E-10 39 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- 2-Mercaptobenzothiazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 309 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Mercaptobenzothiazole 6259 149304 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.65 134 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Decreased body weight. Liver toxicity, increased kidney weight with increased brown pigment. ncreased incidence of basophilic tubules in the kidney cortex. Liver - changes in liver weight Prevalence Magnitude 8 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-TR- 332,1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4,550 Y/N Y/N ug/L ug/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Mercaptobenzothiazole CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 31 Oof 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 23,624 644,590 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 15 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide; vulcanizer; veterinary medicine (HSDB) Value 2.41 3.63E-08 120 23 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- 2-Methylbutane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 311 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Methylbutane 2832 78784 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 357 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Nutritional and Gross Metabolic - weight loss or decreased weight gain, Related to Chronic Data - death Prevalence Magnitude 10 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year 1(3),67,1985 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 833 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Methylbutane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 312 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate; medication (HSDB) Value 15 520 2.72 1.4 48 55 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-Methylpyridine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 313 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Methylpyridine 4741 109068 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0099 674 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood -change in clotting factors, Blood - changes in other cell count (unspecified), Biochemical - Enzyme inhibition, induction, or change in blood ortissue evels - true cholinesterase Behavioral - somnolence (general depressed activity), Behavioral - convulsions or effect on seizure threshold, Behavioral - excitemen Prevalence Magnitude .,, „ 6 5 NLi~Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Qigiena i Sanitariya. ForEnglish translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volu me(issue)/page/year 33(1 2),1 8,1 968 Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 45(12), 62,1980 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0232 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-Methylpyridine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 314 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 5 27,839 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 96 1.11 9.96E-06 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2-Napthalenamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 315 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Naphthalenamine 3487 91598 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 1 1 NL! HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 1.8 1 mg/L (mg/kg-d)"1 (mg/kg-d)-' (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.0194 Y/N Y/N ug/L ug/L OEHHA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Napthalenamine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 316 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 5 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Research chemica ; formerly in dye manufacture (HSDB) Value 1,000 2.28 8.10E-08 6.4 25 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 2-Naphthalenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 317 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Naphthaleno 5876 135193 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 0.437 1,335 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1965 1965 Critical Effect Decreased motor activity Brain and Coverings -other degenerative changes, Behavioral -alteration of classical conditioning Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 3 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/OMezhdunarodnayaKniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 30(9),22,1965. The LOAEL was used for potency/severity scoring because it was lowerthan the NO(A)EL from other studies. Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 30(9), 22,1965 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.02 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Naphthalenol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 318 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr n dyes; as lubricant; former anthe Value 0.45 2.7 4.60E-08 756 24 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes mintic (HSDB) Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 2-Nitropropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 319 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Nitropropane 2889 79469 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 50 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased anemia, thrombocyte count, and heart weight Prevalence Magnitude , „ , 6 5 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; WHO EHC 130 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 9.5 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol.29, Suppl. 7; Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 117 0.0037 Y/N Y/N ug/L ug/L Teratogen CACART; EPA; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Nitropropane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 320 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 294 25,344 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Former pesticide; ndustrial solvent additive; chemica Value 15 days 24.95 0.93 0.000119 17,000 41 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes intermediate (HSDB) Notes BS = Biodegrades slow (PBT) ------- 2-Propanone oxime CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 321 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Propanone oxime 5638 127060 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 5 7 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Clear evidence of carcinogenicity in male/female rats and male/female mice (NTP) Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Propanone oxime CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 322 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 15 days 0.12 7.80E-06 106,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-Pyrrolidone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 323 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-Pyrrolidone 8675 616455 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 80.4 328 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1979 Critical Effect Behavioral - food intake (animal), Kidney, Ureter, Bladder -changes in bladder weight, Blood -changes in serum composition (e.g. TP, bilirubin, cholesterol) Behavioral - coma, Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude 6 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical nformation. Volume(issue)/page/yearOTS0521310-3 Supplemental Data TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Mediteinskogo Instituta. Transactions of the Volgograd State Medical Institute. (Volgogradsk Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR) 1 961 - Volume(issue)/page/year 31 , 1 60, 1 979 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 187.6 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 2-Pyrrolidone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 324 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in pharmaceutical preparations (HSDB) Value 1 5 days 17 -0.85 1.06E-09 1,000,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 2-tert-Butylhydroquinone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 325 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 2-tert-Butylhydroquinone 12479 1948330 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.7 0.2 178.6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgfltg mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg-d mg/kg mg/kg mg/kg Date 1998 1997 Critical Effect Decreased hemoglobin oand/or hematocritand RBC counts No evidence for cancer in mice or rats No evidence of cancer in male or female rats or mice Blood - changes in spleen, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 5 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental data; JEFCA and NTP ADI Maximum Recommended Daily Dose (MRDD); MRDDs were only used for screening, not for attribute scoring No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-TR- 459,1997 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4,900 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 2-tert-Butylhydroquinone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 326 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggragate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Antioxidants in fats and oils (HSDB) Value 38 days 13 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 3,3'-Dichlorobenzidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 327 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3,3'-Dichlorobenzidine 3511 91941 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 2 1 NLi HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.008 0.45 1.2 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1990 1987 Vol. 29, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.08 Y/N Y/N ug/L ug/L EPA, RAISHE, OEHHA, IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3,3'-Dichlorobenzidine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 328 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 2.01 # PWSs/Sites/ Samples 135 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 0 2 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >1M-10M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx n dyes; curing agent for polymers and rubber products (HSDB) Value 7,489 3.51 5.11E-11 3.1 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- 3,3'-Dimethylbenzidine dihydroc CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 329 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3,3'-Dimethylbenzidine dihydrochloride 8575 612828 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 200 1.8 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 1991 Critical Effect Endocrine - changes in thymus weight, Blood - changes in bone marrow (not otherwise specified), Blood - changes in erythrocyte (RBC) count ncreased T3, decreased T4 increased THF, cystic degeneration and foci of cellular alteration in the liver, nephropathy, hyperplasia of Zymbals gland preputial and clitoral glands and alveolar epithelium. Clear evidence of cancer in male and female mice. Prevalence Magnitude 1 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-TR- 390,1991 Supplemental Data; NTP; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page;year NTP-TR-390,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4.2 Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3,3'-Dimethylbenzidine dihydroc CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 330 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n dyes (NTP) Value 18 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (HSDB) ------- 3,4-Dichloro-1-butene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 331 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3,4-Dichloro-1 -butene 9586 760236 Attribute Scores 3-model Categorical Prediction Potency Severity 6 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2 943 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Increased liver weight; increased kidney weight; liver cell enlargement Prevalence Magnitude 8 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3,4-Dichloro-1-butene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 332 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 38 2.6 0.0086 420 61 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 3,6-Dichlorosalicylic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 333 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3,6-Dichlorosa icylic acid 14832 3401807 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3 660 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1978 1978 Critical Effect Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -true cholinesterase, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases, Biochemical - Enzyme inhibition, induction, or change in bl Brain and Coverings - recordings from specific areas of CNS Prevalence Magnitude 6 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issueXpage/year43(10),95,1978; 26-week rat study Supplemental Data mouse study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 43(10), 95,1978 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3,6-Dichlorosalicylic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 334 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (ChemlDPIus) Value 38 days 14 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 3-Chloro-2-methyl-1-propene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 335 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3-Chloro-2-methyl-1-propene 7957 563473 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 214 75 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Related to Chronic Data - death increased instance of forestomach inflammation; clear evidence of cancer in rats and mice Prevalence Magnitude 3 4 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week rat study; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP- TR-300,1986 Supplemental Data; NTP Report 209 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.14 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1995 Vol. 63 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 175 0.25 Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3-Chloro-2-methyl-1-propene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 336 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 6,635 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M nsecticide/fungic Value 81 0.0087 1,400 63 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes de (ChemlDPIus) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- 3-Methylpyridine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 337 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3-Methylpyridine 4735 108996 Attribute Scores 3-model Categorical Prediction Potency Severity 6 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 1986 Critical Effect increased latency on evoked potentials, increae latency of pentylenetetrazol-induged seizures. Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; NTP cites Dyer, et a\., 1 985 rat study; 85JCAE "Prehled PrumysloveToxikolog e; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,841,1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 233 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3-Methylpyridine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 338 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; chemical intermediate (HSDB) Value 110 1.2 7.73E-06 1,000,000 45 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (BIODEG) ------- 3-Pyridinecarbonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 339 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 3-Pyridinecarbonitrile 4116 100549 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5 1,455 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver cell enlargement or alteration, liver and kidney weights were increased. Prevalence Magnitude 6 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 3-Pyridinecarbonitrile CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 340 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide; chemical intermediate; former fumigant (HSDB) Value 38 days 37 0.36 2.74E-07 135,000 48 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4,4'-Bipyridine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 341 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4,4'-Bipyridine 7828 553264 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 172 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Sense Organs and Special Senses (Eye) - lacrimation, Behavioral -somnolence (general depressed activity), Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude 6 7 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year 10,363,1982. Rat study. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 4,4'-Bipyridine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 342 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 38 days 1.28 2.52E-09 4,530 3T Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4,4'-Diaminodiphenyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 343 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4,4'-Diaminodiphenyl ether 4204 101804 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Cardiac - EKG changes not diagnostic of specified effects, Vascular - BP elevation not characterized in autonomic section Prevalence Magnitude 2 2 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-wk rat study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year51(6),31,1986 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.14 2B mg/L (mg/kg-d)"1 (mg/kg-d)1 (mg/kg-d)-1 1987 Vol. 29, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7.9 0.25 Y/N Y/N ug/L ug/L OEHHA, IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4,4'-Diaminodiphenyl ether CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 344 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 621 985 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 38 days 315 2.06 1.50E-11 35 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4,4'-Dichlorodiphenyl sulfone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 345 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4,4'-Dichlorodiphenyl sulfone 2920 80079 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect ncreased incidence or severity of liver lesions;cetrilobular hypertrophy, centrilobilar degeneration and bile diet hyperplasia Brain and Coverings - recordings from specific areas of CNS, Liver - liver function tests impaired Prevalence Magnitude 6 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 47(2), 84,1 982 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4,4'-Dichlorodiphenyl sulfone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 346 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; polymer additive (HSDB) Value 60 days 7,600 3.9 1.40E-07 10 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- 4,4'-Methylenebis(N,N-dimethylb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 347 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4,4l-Methylenebis(N,N-dimethyl)benzenamine 4189 101611 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.08 0.046 0.046 B2 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1987 IRIS Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.8 Y/N Y/N ug/L ug/L RAISHE, EPA, OEHHA, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- 4,4'-Methylenebis(N,N-dimethylb CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 348 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for dyes (HSDB) Value 60 days 14,700 4.37 1.21E-07 4.14 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- 4,4'-Methylenedi(phenyl isocyan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 349 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4,4'-Methylenedi(phenyl isocyanate) 4194 101688 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 3 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," zmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year -,63,1 982. Mouse study. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification D 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1998 1999 Vol., 19, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- 4,4'-Methylenedi(phenyl isocyan CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 350 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data N AWQA ambient water MREC ambient surface water MREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,fl, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Constituent of adhesives and coat ngs (HSDB) Value 376,000 5.22 8.96E-07 0.829 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- 4-Aminobiphenyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 351 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Aminobiphenyl 3566 92671 Attribute Scores Potency Severity 8 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL? - L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 21 1 mg/L (mg/kg-d)"1 (mg/kg-d)1 (mg/kg-d)-1 1987 Vol. 1, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.00167 Y/N Y/N ug/L ug/L OEHHA, IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- 4-Aminobiphenyl CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 352 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 1 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; research chemical (HSDB) Value 38 days 857 2.86 1.50E-07 19 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4-Aminodiphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 353 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Aminodiphenylamine 4183 101542 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 150 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - food intake (animal), nutritional and gross metabolic weight loss of decreased weight gain, related to chronic data - death Prevalence Magnitude 7 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TOXID9 lexicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year 12,103,1992 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 350 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4-Aminodiphenylamine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 354 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye; chemical intermediate for Pharmaceuticals (HSDB) Value 38 days 3,100 3.70E-10 2T Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4-Chloro-1,2-diaminobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 355 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Chloro-1 ,2-diaminobenzene 3792 95830 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.016 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 1987 Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 2.19 Y/N Y/N ug/L ug/L CACART; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4-Chloro-1,2-diaminobenzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 356 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10K-500K Units Ibs/yr Ibs/yr Year 1986 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate and constituent (HSDB) Value 38 days 1.28 4.99E-10 6,590 sr Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4-Chlorobenzotrichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 357 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Chlorobenzotrichloride 16518 5216251 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude , 6 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 20 B2 mg/L (mg/kg-d)1 (mg/kg-d)-1 (mg/kg-d)"1 ung; adenocarcinoma USEPA, 1987 USEPA, 1987; mouse study Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.00175 Y/N Y/N ug/L ug/L EPA; CACART; RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4-Chlorobenzotrichloride CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 358 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 60 days 1,812 4.54 0.000193 4.04 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- 4-Hydroxy-4-methyl-2-pentanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 359 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Hydroxy-4-methyl-2-pentanone 5511 123422 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 40 2,520 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Functional and histopatological effects in the kidney Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 8 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day rat study; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0557741 Supplemental Data rat study; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informat on. Volume(issue)/page/year OTS0557732 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4-Hydroxy-4-methyl-2-pentanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 360 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 21 -0.098 4.24E-09 1,000,000 46 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- 4-Methyl-2-pentanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 361 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Methyl-2-pentanol 4665 108112 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Most likely CMS effects based on inhalation data Prevalence Magnitude ,,, 0 , „ 8 5 NL' L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 401 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 4-Methyl-2-pentanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 362 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; in lubricants and lacquers (HSDB) Value 143 1.43 16,400 35 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- 4-Methyl-3-thiosemicarbazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 363 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Methyl-3-th iosem icarbazide 18177 6610293 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 14 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -tremor, Gastrointestina -changes in structure orfunction of salivary glands, Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude , „ 57 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0571100 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 4-Methyl-3-thiosemicarbazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 364 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 1 5 days 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- 4-tert-Butylcyclohexanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 365 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-tert-Butylcyc ohexanone 3968 98533 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1975 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 9 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. Forpublisher information, see FGTOD7. Volume(issue)/page/year 13,729,1975 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 4-tert-Butylcyclohexanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 366 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 38 days 16 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 4-Vinylcyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 367 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 4-Vinylcyclohexene 4103 100403 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 500 200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg mg/kg Date Critical Effect Nutritional and Gross Metabolic - weight loss or decreased weight gain Inflamatory lesions and epithelial hyperplasia of the forestomach, cytologic alteration of the adrenal cortex • clear evidence of ovarian cancer in female mice and increased incicence of adrenal adenomas - mortality too high to make judgment on male and female Prevalence Magnitude ,,, _ 5 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB91211250 Supplemental Data; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB9121 1250 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1994 Vol. 60; cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 467 Y/N Y/N ug/L ug/L IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 4-Vinylcyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 368 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; polymer intermediate (HSDB) Value 3,300 3.93 0.045 50 35 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- 5-Chloro-o-toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 369 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 5-Chloro-o-toluidine 3789 95794 Attribute Scores Potency Severity 5 9 Prevalence Magnitude 1 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 464 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1973 Critical Effect Details of toxic effects not reported other than lethal dose value 3-model Categorical Prediction L? HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NCILB Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) Volume(issue)/page/year NCI-E-C-72-3252,1973 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 2000 Vol. 77 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 5-Chloro-o-toluidine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 370 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate; in dye formulations (HSDB) Value 38 days 234 2.58 26 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 5-Ethylidene-2-norbornene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 371 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 5-Ethylidene-2-norbornene 25357 16219753 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Hematological effects Prevalence Magnitude ,,, _ 6 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data Supplemental Data; CTDJPN; male Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 28 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 5-Ethylidene-2-norbornene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 372 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Polymer intermec Value 900 0.13 58 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- 5-Nitro-o-anisidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 373 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 5-Nitro-o-anisidine 4039 99592 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Liver - liver function tests impaired, Liver - changes in liver weight, Blood - other changes Prevalence Magnitude , „ 1 8 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day rat study; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 32(3), 48,1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.046 0.049 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 1987 Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,050 0.714 Y/N Y/N ug/L ug/L RAISHE, OEHHA, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- 5-Nitro-o-anisidine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 374 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate (HSDB) Value 38 37.53 1.47 1.47E-08 115 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- 5-Nitro-o-toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 375 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): 5-Nitro-o-toluidine 4036 99558 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL-NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.033 C 3 mg/L (mg/kg-d)1 (mg/kg-d)-1 (mg/kg-d)-1 1990 1990 iver Vol. 48; mouse study; USEPA 1987 USEPA1987 Vol. 48 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1.06 Y/N Y/N ug/L ug/L RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- 5-Nitro-o-toluidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 376 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 255 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate (HSDB) Value 38 days 85.4 1.87 1.94E-08 1,878 26 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodergades slow with acclimation (PBT) ------- Abamectin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 377 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Abamectin 61779 71751412 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 1.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1997 2001 Critical Effect Embryo- and fetotoxicity: increased mortality, reduced weight. Maternal toxicity: reduced body weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 9 3 Li HRL Ratio(s) NC HRL/SWC EEC: 57.4 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat study; HBPTO Handbook of pesticide toxico ogy. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year2,1160,2001 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Abamectin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 378 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total # Sam pies Amount Released 14,932 9 9.3 #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 24 1 2 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Surface water chronic: 0.244 ug/L Non-cancer: 57.4 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Ground water chronic: 0.00371 ug/L Cancer: Pesticide; anthelm ntic (HSDB) Value 5,000 1.70E-07 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (HSDB) ------- Acetaminophen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 379 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Acetaminophen 4349 103902 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL EMEAADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 747 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cholestatic effects Liver - other changes, Kidney, Ureter, Bladder - changes in bladder weight, Nutritional and Gross Metabolic - weight oss or decreased weight gain Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) DSSTOX TD50 EPA Carcinogen classification ARC Carcinogen Classification 495 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 mg/kg-d Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 350 Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude ,,, _ 10 5 NL' HRL Ratio(s) NC HRL/NREC SW MAX: 35 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake; The European Union European Medicines Agency (EIVIEA) Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-394,1992 Supplemental Data Tumorigenic Dose - 50 DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetaminophen CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 380 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, etal., 2007 Focazio, etal., 2008 HRL Ratios (HRL/NREC SW MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 84 Amount Released # PWSs/Sites/ Samples Units Ibs/yr Ibs/yr Ibs/yr #with Detects 23.8 Number of States % PWSs/Sites/ Samples with detects 0 Units States States States Minimum value of Detects Not detected Non-cancer: 35 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 10 Year Maximum value of Detects Not detected 0.16 0.11 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 90% of Detects Not detected Units for Mag data ug/L Notes Drinking water monitoring; Snyder, et al., 2007. Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association. Focazio, etal., 2008. Sci.Tot. Env., 402(2-3), pp. 201-216. Cancer: Pharmaceutical Value 15 41 0.46 6.42E-13 14,000 38 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow ------- Acetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 381 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetic acid 2464 64197 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1.47 3,310 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1972 1959 Critical Effect Gastrointestinal - changes in structure orfunction of esophagus, Gastrointestinal - ulceration or bleeding from small intestine, Gastrointestinal - ulceration or bleeding from large intestine Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 5 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AIHAAP American Industrial Hygiene Association Journal. (AIHA,475Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year 33,624,1972. Human study Supplemental Data rat study; DMDJAP Delaware State Medical Journal. (Wilmington, DE) V.1-32(1), 1929-60. For publisher information, see DSMJAA. Volume(issue)/page/year 31,276,1959 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.43 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 382 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; veterinary medicine; chemical reagent (HSDB) Value 6.5-228 -0.71 1,000,000 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Acetic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 383 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetic anhydride 4676 108247 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,780 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1951 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 10 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year4,119,1951; rat study Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 384 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; chemica reagent (HSDB) Value 4.4 minutes 120,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Acetone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 385 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetone 2510 67641 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.9 0.9 2 100 3,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2003 2003 1994 Critical Effect Nephrotoxicity Nephropathy Hemato. Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Blood - normocytic anemia Prevalence Magnitude 9 7 Li HRL Ratio(s) NC HRL/NAWQA 90% : 568 Notes Reference Dose Reference Dose; rat study; UF = 1000, MF = 1; Dietz, et., al, 1991; NTP, 1991 Reference Dose Reference Dose Minimal Risk Level, UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NIH-91-3122 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 6,300 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 386 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,605 # Sam pies Amount Released # PWSs/Sites/ Samples 653 168 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 25 6.45 % Samples with detects Number of States % PWSs/Sites/ Sam pies with detects 3.83 0.3 Minimum value of Detects Units States States States Minimum value of Detects 2 Non-cancer: 568 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 1,806 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 210 2.77 Median value of Detects 11.1 90% of Detects 52.4 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 11 90% of Detects 114 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Solvent; in PPCPs (HSDB) Value 1.98 -0.24 3.96E-05 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Acetone cyanohydrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 387 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetone cyanohydrin 2688 75865 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0008 14.8 1.90 Units mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1971 1994 Critical Effect increased relative weight; liver Gastrointestinal - ulceration or bleeding from stomach, Liver - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 4 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; UF = 3,000; Rat study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 35-wk rat study; AMPMAR Archives des Maladies Professionnelles de Medecine du Travail etde Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year 32,653,1971 Supplemental Data Mouse study; TOVEFN Toksikologicheskii Vestn k. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year (1), 29,1994 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5.6 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetone cyanohydrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 388 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 106,961 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 4 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; (HSDB) Value 1 -0.03 1.30E-05 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- Acetonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 389 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acetonitrile 2621 75058 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.006 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood- decreased hematocrit; Liver- increased relative weight; hepatic lesions; erythrocyes- decreased cell count Prevalence Magnitude 10 10 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 42 Y/N Y/N ug/L ug/L Teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acetonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 390 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 11,220 12,784,367 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 14 30 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; in PPCPs; chemical intermediate (HSDB) Value 4.5 -0.34 3.45E-05 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- Acrylic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 391 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acrylic acid 2862 79107 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 0.5 0.135 250 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1983 Critical Effect Reduced pup weight iver Behavioral - fluid intake, Kidney, Ureter, Bladder - changes in bladder weight, Related to Chronic Data - changes in testicular weight Prevalence Magnitude 10 10 HRL Ratio(s) No water data Notes Reference Dose Reference Dose. BASF, 1993. Rat study Reference Dose BASF, 1993. rat study, uf=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year 6,1,1983; oral study in rat Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol. 19, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N ug/L ug/L Teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acrylic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 392 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 19,798 6,817,569 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 9 30 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical and polymer intermediate (HSDB) Value 1.201 0.35 3.69E-07 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF/BST Notes BF = Biodegrades fast (BIODEG); BST = Biodegrades somet mes/recalcitrant (BIODEG) ------- Acrylonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 393 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Acrylonitrile 4592 107131 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.04 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1984 Critical Effect decreased sperm counts Hemato.; decreased red cell counts Endocrine - adrenal cortex hyperplasia, Endocrine - changes in adrenal weight, Blood - other changes Prevalence Magnitude 1 1 HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Leve ; Biodynamics, 1980b. Rat study; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year 4, 1 31 , 1 984; 60-day rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.006 0.54 1 B1 2A mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1990 1999 Biodynamics, 1980a,b; Quastetal., 1980a; rat study OEHHA lists IARC classification of 2B Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 7 0.06 Y/N Y/N ug/L ug/L Teratogen list EPA, RAISHE, OEHHA, IARC, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Acrylonitrile CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 394 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,614 # Sam pies Amount Released 21,559 7,925,644 # PWSs/Sites/ Samples 180 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 % Samples with detects Number of States 10 29 % PWSs/Sites/ Samples with detects 0 Not Detected Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range > 1B > 1B Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide/fumigant; polymer intermediate (HSDB) Value 8.3 0.25 0.000138 74,500 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Adipic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 395 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Adipic acid 5549 124049 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4,000 800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect gastrointestinal effects: hypermotility, diarrhea and weight ow or decreased we ght gain Chronic inflamatory alterations of the intestines Prevalence Magnitude ,,, ,,, _ 10 5 NL NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FAO Nutrition Meeting Reports 401 1 1 967 Supplemental Data; FDA/Informatics. NTIS PB230 305 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,867 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Adipic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 396 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; in PPCPs; polymer intermediate (HSDB) Value 26 0.08 4.70E-12 14,000-30,000 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Adiponitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 397 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Adiponitrile 4964 111693 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 22 22 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1996 1984 Critical Effect Maternal toxicity Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 10 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data. Journal. Johannsen et al 1986 Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J. Sax's Dangerous Properties of Industr al Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 73. Rabbit study. rabbit study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 49(12), 40,1984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Adiponitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 398 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical and polymer intermediate (HSDB) Value 16 -0.32 1.21E-09 80,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Aldrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 399 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Aldrin 6511 309002 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00003 0.00003 0.00003 0.00003 0.0001 0.0001 0.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1992 2000 1994 2000 1966 Critical Effect iver lesions, increased liver to body weight ratio iver iver Endocrine - other changes, Blood - other changes Prevalence Magnitude , „ 1 6 L' HRL Ratio(s) CAR HRL/NCOD R2 90% : 4.55 Notes Reference Dose Reference Dose; Fitzhugh et al., 1964; Basis LOAEL 0.025, rat, UF=1000. Reference Dose Reference Dose Minimal Risk Level; Fitzhugh et a ., 1964; Basis LOAEL 0.025; rat study; UF = 1,000 Acceptable Daily Intake; combined total for aldrin and dieldrin Acceptable Daily Intake Tolerable Daily Intake; Fitzhugh and Nelson, 1963; Fitzhugh etal., 1964; Basis LOAEL 0.025; rat study, dog study; UF = 250 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year31(4),13,1966; 26-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0002 17 17 B2 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1992 1992 1987 Vol. 5, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.21 0.002 Y/N Y/N ug/L ug/L Teratogen EPA, RAISHE, OEHHA, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Aldrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 400 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,221 12 0.0982 0.1 4.4 0.84 4.4 4.4 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS POP HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 2,961 # PWSs/Sites/ Samples 5,226 105 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 32 % Samples with detects Number of States 1 4 % PWSs/Sites/ Sam pies with detects 0.61 Minimum value of Detects Units States States States Minimum value of Detects 0.01 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 107 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99 90% of Detects 102 Units for Mag data ug/L ug/L Cancer: 4.55 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx 2002 Former insecticide (HSDB) Value 106,000 6.5 4.40E-05 0.017 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (HSDB) ------- alpha-Chlorohydrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 401 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): alpha-Chlorohydrin 3823 96242 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 5 26 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date 2000 1994 1982 Critical Effect Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count), Reproductive - Fertility - other measures of fertility Reproductive - Paternal Effects (sperm motility and count) Behavioral - somnolence (general depressed activity), Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , „ 5 7 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; rat study. REPTED Reproductive Toxicology. (Pergamon Press nc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year 15,11,2000 Supplemental Data; Reproductive Toxicology Volume 8, Issue 3, May^June 1994, Pages 237-250 rat study; IPCLBZ International Pest Control. (McDonald Pub., 238A High St., Uxbridge, Middx., UK) V.5- 1962- Volume(issue)/page/year 24,20,1982 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 11.7 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- alpha-Chlorohydrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 402 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; chemical intermediate (HSDB) Value 1 5 days 1 6.10E-08 1,000,000 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- alpha-Methylbenzenemethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 403 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): alpha-Methylbenzenemethanol 3990 98851 Attribute Scores 3-model Categorical Prediction Potency Severity 3 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 375 1,071 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1990 Critical Effect Decreased body weight gain, impaierd renal function, early mortality CancerPositive male rat and female mouse, negative female rat and male mouse Liver - changes in liver weight, Related to Chronic Data - death Prevalence Magnitude , „ 10 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue);pagefyear NTP-TR-369,1990 Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-369,1990; 13-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,625 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- alpha-Methylbenzenemethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 404 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B Units Ibs/yr Ibs/yr Year 1994 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flavoring agent; n PPCPs; laboratory reagent (HSDB) Value <5-52 2.90E-07 1,950 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- alpha-Methylstyrene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 405 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): alpha-Methylstyrene 3989 98839 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value o.or 1,000 50 4,500 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1990 1963 Critical Effect increased weight, liver reproductive/developmental Kidney, Ureter, Bladder - proteinuria, Blood - changes in eukocyte (WBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; rat study; UF = 1 ,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGH "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. Volume(issue)/page/year -,203,1990; 4-wk rat study Supplemental Data mouse study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 28(12), 14,1963 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 490 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- alpha-Methylstyrene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 406 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life KOC> Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Polymer intermec Value 817.2 3.48 0.00254 89 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate; UV degradaton inhibitor (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- Ametryn CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 407 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ametryn 9881 834128 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.072 0.009 0.009 0.009 25 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1988 1987 2001 Critical Effect Liver toxicity. Degenerative & inflam matory liver effects iver toxicity iver Nutritional and Gross Metabolic - weight loss or decreased weight gain; Blood - other changes Prevalence Magnitude ,,, _ 6 6 NL' HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose; Supplemental Data; OPP. Ciba-Geigy, 1961a Reference Dose; Ciba-Geigy, 1961 a. rat study; Basis NOEL 8.6 mg/kg-d; UF = 1,000 Reference Dose Reference Dose; Ciba-Geigy, 1961 a. rat study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 2,1 51 4,2001 ; 2-yr rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 504 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ametryn CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 408 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 445,571 31 409 # PWSs/Sites/ Samples 75 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 5 3 5 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 445 2.98 2.39E-09 209 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (HSDB) ------- Amitraz CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 409 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Amitraz 32124 3308961 1 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0125 0.0025 0.0025 0.01 100 Units mg(kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 1998 1978 Critical Effect Hypothermia, drowsiness, decreased blood pressure & heart rate blood sugar increase, hypothermia increased mean blood sugar concentration Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, _ 9 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Upjohn Co., 1972a; Basis NOEL = 0.25 mg/kg-d; Dog study; UF = 100 Reference Dose Reference Dose; Upjohn 1973; UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Dog study - SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year 78-1,22,1978 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 87.5 Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Amitraz CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 41 Oof 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 137,097 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 17 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide; veter nary medication (HSDB) Value 38 644,000 5.5 9.89E-06 1 7 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Ammonia CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 411 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ammonia 19125 7664417 Attribute Scores 3-model Categorical Prediction Potency Severity 6 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOAEL RTECS Lowest Oral Chronic LOAEL Supplemental LOEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6.18 0.9 Units mg/kg-d mg/kg-d mg/kg-d mg/L mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 2006 Critical Effect Gastrointestinal - other changes Taste threshold Prevalence Magnitude 10 10 HRL Ratio(s) NC HRL/DBP ICR MED: 150 Notes Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; DDSCDJ Digestive Diseases and Sciences. (Plenum Pub. Corp., 233 Spring St., New York, NY 1001 3) V.24- 1979- Volume(issue)/page/year 36,33,1991; 4-wk rat study Lowest Observed Effect Level. EPA: 2006 Edition of the Drinking Water Standards and Health Advisories. EPA 822-R-06-01 3. Note: Taste threshold of 30 mg/L converted to a dose using 2 L/d drinking water intake and 70 kg body weight. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1992 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 30,000 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level HRL set at taste threshold of 30 mg/L 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ammonia CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 412 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF IOR # PWSs/Sites sampled 68 #with Detects 58 % PWSs/Sites with detects 85.29 Minimum value of Detects Maximum value of Detects 1,100 Median value of Detects 200 Mean value of Detects 262 Units for Mag data ug/L Ambient Water Occurrence Data # PWSs/Sites sampled NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T1C, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects 8,185 # Sam pies Amount Released 6,284,889 172,424,459 n PWSs/Sites/Sa mples 535 % PWSs/Sites with detects 5,907 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 171 Minimum value of Detects 72.2 % Samples with detects Number of States 50 54 % PWSs/Sites/Sam pies with detects 32 Maximum value of Detects 2 Minimum value of Detects Units States States States Minimum value of Detects 10 Non-cancer: 150 Amount Range >10M-50M >500M - 1 B Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 34,000 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 15,000 90% of Detects 43 Median value of Detects 99% of Detects 284 90% of Detects Units for Mag data 2,400 99% of Detects Units for Mag data ug/L ug/L ug/L Notes Notes ug/L ug/L ug/L Units for Mag data ug/L ug/L Measured as N National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 231 99% of Detects 1,291 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermediate; defoliant; antifungal agent for produce (HSDB) Value 14.3 -1.38 3.45E-06 3,740 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Ammonium carbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 413 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ammonium carbamate 10601 1111780 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 681 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - somno ence (general depressed activity), Lungs, Thorax, or Respiration -dyspnea, Skin and Appendages - hair Prevalence Magnitude , „ 10 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issueXpage;yearOTSOS35595; rat study Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ammonium carbamate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 414 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in fertilizers (HSDB) Value 1 5 days -3.67 very soluble 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Ammonium thiosulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 415 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ammonium thiosulfate 19349 7783188 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,098 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 7 ncomplete data for scoring HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 1 13095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 26(6),54,1982. Guinea pig study Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ammonium thiosulfate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 416 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50-100M >50-1QOM Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide; defoliant; in PPCPs (HSDB) Value very soluble Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Aniline hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 417 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Aniline hydrochloride 6119 142041 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 NOTE: SK 61 19 s the salt of ani ine (SK 2438) Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 Critical Effect Endocrine - changes in spleen weight, Blood - methemoglobinemia-carboxyhemoglobin, Blood - changes in erythrocyte (RBC) count Prevalence Magnitude ,,, 1 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; AECTCV Archives of Environmental Contam ination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page;year 24,368,1993. 90-day rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 46.7 Y/N Y/N ug/L ug/L Teratogen list CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Aniline hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 418 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer and chemcal intermediate; in PPCPs, in inks (HSDB) Value 1 5 days 44-489 0.9 2.02E-06 36,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) Environmental fate parameters are for the free base, not the hydrochloride salt. ------- Anisole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 419 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Anisole 4127 100663 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.65 2,800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1946 Critical Effect Endocrine - other changes Behavioral - tremor, Behavioral - convulsions or effect on seizure threshold, Behavioral - excitement Prevalence Magnitude ,,, _ 3 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVQK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page7year -,290,1994. 26- wk rabbit study Supplemental Data mouse study; JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 88,400,1946 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.517 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Anisole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 420 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flavoring agent; n PPCPs; chem cal intermediate (HSDB) Value 35 2.11 0.00435 1,520 31 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Aspirin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 421 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Aspirin 2149 50782 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0021 66.7 200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2002 1969 Critical Effect Lungs, Thorax, or Respiration -tumors Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 1 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RQ21 2XS, UK) V.1- 1947- Volume(issue)/page/year 87,49,2002. 24-wk female human study Supplemental Data; Maximum Recommended Da ly Dose (MRDD) rat study; 34ZIAG "Toxicology of Drugs and Chemcals," Deichmann, W.B., New York, Academic Press, nc., 1969 Volume(issue)/page/year-,67,1969 Cancer Data - no quantitative risk estimate for the cancer effect was identified EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.005 Y/N Y/N ug/L ug/L Teratogen list CACART, UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Aspirin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 422 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Medication (HSDB) Value 5.4-6.3 days 42-106 1.19 1.30E-09 4,600 33 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Auramine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 423 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Auramine 7200 492808 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.168 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Prevalence Magnitude 1 1 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year 105,45,1974. 17-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.88 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1987 Vol. 1, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.392 Y/N Y/N ug/L ug/L OEHHA, CACART, IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Auramine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 424 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n dye manufacture; medication; fungicide; antiseptic (HSDB) Value 65-74 days 2,000 3.5 8.05E-08 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DST Notes Degrades sometimes/recalcitrant (HSDB) ------- Azinphos-methyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 425 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Azinphos-methyl 3200 86500 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00149 0.005 0.91 Units mgflsg mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 1997 Critical Effect RBC ChE inhibition, increased incidence of diarrhea Brain and Coverings - other degeneratve changes, Blood - other changes, Biochemical - Enzyme nhibition, induction, or change in blood or tissue levels - true cholinesterase Prevalence Magnitude 8 3 NLi HRL Ratio(s) NC HRL/NAWQA 90% : 68.9 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, seeTOSCF2 Volume(issue)/page/year35,101,1997; 1 3-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW MAC Y 10.4 0.2 Y/N Y/N ug/L ug/L mg/L UMD Drinking Water Equivalent Level Canadian Drink ng Water Maximum Allowable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Azinphos-methyl EPA-OGWDW August 2009 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,103 # Sam pies Amount Released 2,091,014 # PWSs/Sites/ Samples 283 669 12 145 #with Detects Units Ibs/yr Ibs/yr Ibs/yr # of detects 8 5 0 2.04 % Samples with detects Number of States 42 % PWSs/Sites/ Samples with detects 2.5 2.2 0 0.002 Minimum value of Detects Units States States States Minimum value of Detects 0.012 0.012 Non-cancer: 68.9 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 3.37 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.021 0.253 0.144 0.114 0.027 Median value of Detects 0.151 90% of Detects 0.932 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate National Aggragate Notes Median value of Detects 95th % lie value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 Pesticide Data Program (USDA); 2002 Pesticide Pilot Mentoring Program (USGS/EPA) raw water data Pesticide Pilot Mentoring Program (USGS/EPA) finished water data Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Insecticide (HSDB) Value 27.9 days 487-4,644 2.75 2.40E-08 20.9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DS Notes DS = Degrades slow (HSDB) ------- Bentazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 427 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bentazon 28242 25057890 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.03 0.03 0.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1998 1999 1989 1998 Critical Effect Blood loss into the gastrointestinal tract; Coagulation defect in male & female dogs, Circu atory system . blood loss in gastrointestinall tract; coagulation defect Prevalence Magnitude ,,, _ 9 4 NL' HRL Ratio(s) NC HRL/NAWQA 90% : 276 Notes Reference Dose Reference Dose; Allen et al., 1 989. Dog study; UF = 100, Basis NOAEL 3.2 mg/kg-d Reference Dose Reference Dose; UF = 100; dog study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification E mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1998 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer WHO DWQ 210 300 Y/N Y/N ug/L ug/L ug/L Drinking Water Equivalent Level World Health Organization Drink ng Water Guide 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bentazon EPA-OGWDW August 2009 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,540 # Sam pies Amount Released 7,749,130 # PWSs/Sites/ Samples 100 186 n PWSs/Sites/Sa mples 5,583 197 #with Detects Units Ibs/yr Ibs/yr Ibs/yr # of detects 1 14 80 21 n of detects 2 4.339 % Samples with detects Number of States 45 % PWSs/Sites/ Samples with detects 1 7.5 25.6 9.3 % PWSs/Sites/Sam pies with detects 0.04 0.002 Minimum value of Detects Units States States States Minimum value of Detects 0.0188 0.002 Minimum value of Detects 0.23 Non-cancer: 276 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 11.5 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.0188 0.018 0.344 0.019 Maximum value of Detects 6.2 0.1 Median value of Detects 0.76 90% of Detects 4.79 99% of Detects Units for Mag No(es data ug/L ug/L ug/L ug/L ug/L National Reconnaissance ug/L National Reconnaissance Units for Mag No(es data ug/L National Aggregate ug/L National Aggregate Notes Median value of Detects Median value of Detects 3.11 95th % lie value of Detects 0.021 0.019 90th % lie value of Detects 5.58 Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L Cancer: Notes Pesticide Data Program (USDA); 2002 Pesticide Data Program (USDA); 2002 Pesticide Pilot Mentoring Program (USGS/EPA) raw water Pesticide Pilot Mentoring Program (USGS/EPA) finished water Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former herbicide (HSDB) Value 6.7-50 days 37.5 2.34 2.18E-09 500 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (HSDB) ------- Benzaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 429 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzaldehyde 4114 100527 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 17.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1994 Critical Effect Forestomach hyperplasia & lesions, kidney toxicity renal tubular necrosis). Gl tract, Kidney forestomach, kidney; lesions, toxicity Lungs, Thorax, or Respiration - other changes, Liver - multiple effects Prevalence Magnitude .,, „ 6 7 NLi~Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Kluwe et al., 1 983; rat study; UF = 1 ,000; Basis NOEL 200 mg/kg-d Reference Dose Reference Dose; rat study; Kluwe, 1983; UF = 1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing substances), Sandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,396,1994; 5-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzaldehyde CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 430 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; chemical intermediate (HSDB) Value 32.7 1.48 2.67E-05 6,570 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Benzidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 431 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzidine 3586 92875 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 2.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect brain, liver brain, liver; cell vacuo izations, call alterations Prevalence Magnitude , „ 3 1 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Littlefield etal., 1983; mouse study Reference Dose Reference Dose; Littlefield etal., 1983; mouse study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.00002 230 500 A 1 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 IRIS Vol. 29, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 21 0.0002 Y/N Y/N ug/L ug/L EPA; RAIS; OEHHA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzidine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 432 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 66.61 82.92 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye manufacture; chemical intermediate (HSDB) Value 2,740 1.34 7.05E-11 322 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Benzofuran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 433 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzofuran 6383 271896 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 Critical Effect Nephropathy (males) chronic inflamation, ulcers and epitheliam hyperplasia of the stomach Clear evicence of cancer in male and female mice, some evidence in female rats, no evidence in male rats Prevalence Magnitude 1 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 3-wk rat study Supplemental Data; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/pagefyear NTP-TR-370,1 989 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1995 Vol. 63 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 Y/N Y/N ug/L ug/L IARC, CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzofuran CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 434 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n resin manufacture (HSDB) Value 1 5 days 680 2.67 0.00053 24 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Benzoic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 435 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzoic acid 2484 65850 Attribute Scores 3-model Categorical Prediction Potency Severity 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4 4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect No adverse effects observed. Decreased Potency Score by one integer Prevalence Magnitude ,,, 87 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose; FDA, 1973; human study; Basis NOAEL 34 mg/kg-d; UF = 1 Reference Dose Reference Dose; FDA, 1973; human study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 1989 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 28,000 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Benzoic acid CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 436 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total FRI Release - surface water FRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,E, Half life Koc, Organic Carbon Partition Coefficient og Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1DOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; food preservative; chemical intermediate (HSDB) Value 0.2-3.6 days 14.49 1.87 3.82E-08 3,400 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Benzotriazole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 437 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzotriazole 3739 95147 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.599 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect Endocrine - other changes, Blood - normocytic anemia, Blood - leukopenia Prevalence Magnitude 57 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 46(1 1 ),70,1 981 ; 26-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.4 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Benzotriazole CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 438 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Photographic chemical; chemical ntermediate; plastics stabilizer; corrosion nhibitor (HSDB) Value 145 1.44 3.17E-07 19,800 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (BIODEG) ------- Benzotrichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 439 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzotrichloride 3933 98077 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Liver - other changes, Liver - changes n liver weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Prevalence Magnitude 42 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing substances), Sandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,43,1994; 28-day rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0003 13 B2 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1990 ung IRIS Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.07 0.003 Y/N Y/N ug/L ug/L CACART; EPA; RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Benzotrichloride CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 440 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 745 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 4 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1,180 3.9 0.000259 21.7 8 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Benzyl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 441 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Benzyl alcohol 4113 100516 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 143 5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 Critical Effect Epithelial hyperplasia, forestomach Brain and Coverings - other degeneratve changes, Related to Chronic Data - death Prevalence Magnitude .,, „ 6 7 NLi~Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; NTP, 1988. rat study; UF = 1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-343,1989; 13-wk rat study Supplemental Data; Maximum Recommended Da ly Dose (MRDD) Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,100 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Benzyl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 442 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 15.7 1.1 3.38E-07 42,900 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast(BIODEG) ------- Bis(2-chloro-1-methylethyl) eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 443 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bis(2-ch loro-1 -m ethylethyl) ether 4702 108601 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 2 2 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 12.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 Critical Effect Blood - changes in leukocyte (WBC) count, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other Enzymes 3-model Categorical Prediction NL-NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 50(5), 69,1985; 26-wk rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification o.or c 3 mg/L (mg/kg-d)1 (mg/kg-d)-1 (mg/kg-d)"1 1999 Vol. 41, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 30.1 0.5 Y/N Y/N ug/L ug/L CACART; RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bis(2-chloro-1-methylethyl) eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 444 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 883 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent; medication (HSDB) Value 39.2 2.48 0.000113 1,700 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Bis(2-chloroethyl) ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 445 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bis(2-chloroethyl) ether 4939 111444 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 26 25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1981 Critical Effect Brain and Coverings - other degeneratve changes, Liver - multiple effects, Kidney, Ureter, Bladder - other changes Decreased body weight Prevalence Magnitude 4 2 Li HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGK Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soed nenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et a ., Chimia, 1994. Volume(issue)/page/year -,283,1994; 45 day oral study n rat ATSDR; Weisburger, etal., 1981. Journal of the National Cancer Institute, 67: 75-88. Cancer Data EPA Lifetime Cancer Risk, 104 ATSDR Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.003 0.3 1.1 2.5 B2 3 mg/L mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1988 1999 IRIS ATSDR Vol. 9, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 60.67 0.03 Y/N Y/N ug/L ug/L EPA; RAISHE; OEHHA; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bis(2-chloroethyl) ether CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 446 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2 478 # PWSs/Sites/ Samples 2,348 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 4 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; chemical intermediate; solvent; gasoline additive (HSDB) Value 14.95 1.29 1.70E-05 17,200 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA/BS/BST Notes BFA = Biodegrades fast with acclimat on; BS = Biodegrades slow; BST = B odegrades sometimes/recalcitrant (BIODEG) ------- Bis(2-ethylhexyl) sodium sulfos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 447 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bis(2-ethylhexyl) sodium sulfosuccinate 8032 577117 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 5 1,900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1943 1962 Critical Effect Behavioral -food intake (animal), Gastrointestinal - hypermotility, diarrhea, Related to Chronic Data - death Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 3 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year 25,175,1943; 24 wk rabbit study Supplemental Data; Maximum Recommended Da ly Dose (MRDD) Rat study; JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1 995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year 13,469,1962 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.17 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bis(2-ethylhexyl) sodium sulfos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 448 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; in PPCPs; medical on (HSDB) Value 9.37-1,041 5.00E-12 71,000 22 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Bis(chloromethyl) ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 449 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bis(chloromethyl) ether 7727 542881 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude , „ 1 1 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.000016 220 46 A 1 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1991 1987 ung IRIS Vol. 4, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.00016 Y/N Y/N ug/L ug/L EPA; RAISHE; OEHHA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bis(chloromethyl) ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 450 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Laboratory reagent; in polymer manufacture (HSDB) Value 4.395 0.58 0.000206 22,000 48 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Bisphenol A CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 451 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Bisphenol A (4,4'-lsopropylidenediphenol) 2918 80057 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 0.05 2.5 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Reduced body weight Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 350 Y/N Y/N ug/L ug/L Prevalence Magnitude 10 5 NLi HRL Ratio(s) NC HRL/NREC NA SW MED: 1,750 Notes Reference Dose Reference Dose; Basis = LOAEL 50 mgflsg-d; UF = 1,000 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat Supplemental Data UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bisphenol A CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 452 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Kolpin, etal.,2002 Stackelberg, etal., 2007 Stackelberg, etal., 2007 Focazio, etal., 2008 HRL Ratios (HRL/NREC NA SW MED) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 85 # Sam pies Amount Released 3,538 1,504,711 # PWSs/Sites/ Samples 73 35 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 7 41.2 % Samples with detects 21.07 10.78 Number of States 8 27 % PWSs/Sites/ Samples with detects 41.2 17 67 9.6 Minimum value of Detects Units States States States Maximum value of Detects 12 0.22 0.36 1.9 Non-cancer: 1,750 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Units for Mag data ug/L ug/L ug/L ug/L 0.14 Median value of 90% of „„„, . „ . . 99% of Detects Detects Detects 0.2 0.2 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Notes Surface water monitoring; Kolpin, eta., 2002. Env. Sci. &Technol., 36(6), pp. 1202-1211. New Jersey Finished Drinking Water; Stackelberg, etal., 2007. Sci. Tot. Environ., 377(2-3), pp. 255-272. New Jersey Surface Water; Stackelberg, et al., 2007. Sci. Tot. Environ., 377(2-3), pp. 255-272. NREC II Raw Drinking Water; Focazio, et al., 2008. Sci.Tot. Env., 402(2-3), pp. 201-216. Cancer: Production of polycarbonate and epoxy resins. Formely used as fungicide. (HSDB) Value 75,200 3.32 9.2E-12 120 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA-BST Notes BFA = Biodegrades fast with acclimat on; BST = Biodegrades sometimes/recalcitrant ------- BMX-1 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 453 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): BMX-1 (3-Chloro-4-(bromochloromethyl)-5- hydroxy-2(5H)-furanone) 78954 132059519 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification HM mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 1 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; HM = High to medium probability of be ng carcinogenic DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- BMX-1 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 454 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al., 2006 HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/ Samples with detects 44 Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.17 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.01 90% of Detects Units for Mag data ug/L Cancer: Notes Finished drinking water monitoring; Krasner, era./, 2006. Env. Sci. Technol. , 40(23), pp 7175-7185 (and related documentation). Disinfection By-Product Value Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- BMX-2 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 455 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): BMX-2 (3-Chloro-4-(dibromomethyl)-5-hydroxy- 2(5H)-furanone 74966 132059520 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification HM mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 1 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; HM = High to medium probability of be ng carcinogenic DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- BMX-2 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 456 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al., 2006 HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/ Sam pies with detects 33 Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.03 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects ND 90% of Detects Units for Mag data ug/L Cancer: Notes Finished drinking water monitoring; Krasner, et al., 2006. Env. Sci. Technol., 40(23), pp 7175-7185 (and related documentation). Disinfection By-Product Value Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- BMX-3 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 457 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): BMX-3 (3-Bromo-4-(dibromomethyl)-5-hydroxy- 2(5H)-furanone 78951 132059531 Attribute Scores Potency Severity Prevalence Magnitude 10 1 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification HM mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L ug/L ug/L 3-model Categorical Prediction HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; HM = High to medium probability of be ng carcinogenic DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- BMX-3 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 458 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al., 2006 HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/ Samples with detects 11 Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 0.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects ND 90% of Detects Units for Mag data ug/L Cancer: Notes Finished drinking water monitoring; Krasner, et al., 2006. Env. Sci. Technol., 40(23), pp 7175-7185 (and related documentation). Disinfection By-Product Value Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Boron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 459 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Boron 18864 7440428 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.09 0.09 0.01 31 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 1970 Critical Effect Decreased fetal weight (developmental) Atrophy and spermatigenetic arrest Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other transferases Prevalence Magnitude 10 10 HRL Ratio(s) NCHRL/NIRS90%:2.95 Notes Reference Dose Reference Dose; Price etal., 1996a; Heindel etal., 1992 Reference Dose Reference Dose; Basis = NOAEL/LEL, MF = 1, UF= 100, dog, testicle (Weir & Fisher, 1972) Minimal Risk Level - Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rabbit; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 35(1 1 ) , 1 1 , 1 970 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer WHODWQ CADW MAC 3 1,400 0.5 5 Y/N Y/N mg/L ug/L ug/L mg/L mg/L 1992 Drinking Water Equivalent Level World Health Organization Drink ng Water Guide Canadian Drink ng Water Maximum Allowable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Boron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 460 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 810 81.9 5 3,950 46.8 475 2,585 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites/ Samples 9,360 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 4,841 % Samples with detects Number of States % PWSs/Sites/ Sam pies with detects 51.7 Minimum value of Detects Units States States States Minimum value of Detects 0.01 Non-cancer: 2.95 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 800,800 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 180 90% of Detects 730 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; oxygen scavenger; catalyst; in composite structural mater als (HSDB) Value 14.3 0.23 0.0245 43,700 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- Bromacil CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 461 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bromacil 6526 314409 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 62.5 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1970 Critical Effect Decreased body weight gain Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 8 5 NLi HRL Ratio(s) NC HRL/NAWQA 90% : 206 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 35(1 1 ) , 1 1 , 1 970 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 5 700 Y/N Y/N mg/L ug/L ug/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Bromacil CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 462 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,555 # Sam pies Amount Released 614,219 0 0 # PWSs/Sites/ Samples 100 197 # PWSs/Sites/ Samples 7,392 108 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 2 49 #with Detects 3 2.37 % Samples with detects 15.2 0.61 Number of States 4 0 0 % PWSs/Sites/ Sam pies with detects 0 0 0.9 15.7 % PWSs/Sites/ Samples with detects 0.04 0.001 Minimum value of Detects Units States States States Minimum value of Detects Minimum value of Detects 0.93 Non-cancer: 206 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 57 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.481 0.481 Maximum value of Detects 4 0.245 Median value of Detects 0.675 0.57 3.4 90% of Detects 25.9 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 1.5 95% of Detects 0.081 90% of Detects 3.18 Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L Cancer: Notes Pesticide Data Program (USDA); 2001 Pesticide Data Program (USDA); 2002 Pesticide Pilot Mentoring Program (USGS/EPA) finished water data Pesticide Pilot Mentoring Program (USGS/EPA) ambient water data Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 64-275 days 2.3-289 2.11 1.29E-10 815 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Bromine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 463 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bromine 19194 7726956 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 440 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 8 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issueXpage/year 39(4),86,1974 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Bromine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 464 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 5 381,257 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 15 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n water disinfect on; flame retardant; chemical intermediate; in dyes; med cation (HSDB) Value 33,600 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Bromobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 465 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bromobenzene 4724 108861 Attribute Scores Potency Severity 5 6 Prevalence Magnitude 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver lesions 3-model Categorical Prediction NL? HRL Ratio(s) NC HRL/NCOD R1 90%: 21.4 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bromobenzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 466 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,450 24,125 32 31 0.195 0.128 0.04 0.05 40 4.69 1 0.5 6.55 3 40 4.69 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 # Sam pies Amount Released # PWSs/Sites/ Samples 11,878 3 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 0.07 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 0.03 0.009 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Non-cancer: 21.4 Amount Range >500K-1M >500K-1M Units Ibs/yr Ibs/yr Year 1998 2002 0.4 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 83 0.012 Median value of Detects 0.4 90% of Detects 0.4 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.74 90% of Detects 66.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx n organic synthesis; as solvent (HSDB) Value 268 2.99 0.00269 446 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Bromochloroacetonitrile (SCAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 467 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Bromochloroacetonitrile (BCAN) 66739 83463621 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification 3 M mg/L (mg/kg-d)"1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L ug/L ug/L Prevalence Magnitude 10 7 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; M = Medium probability of being carcinogenic DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bromochloroacetonitrile (SCAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 468 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR finished water # PWSs/Sites sampled #with Detects % PWSs/Sites with detects 62.5 Mean value of Detects 1.63 Maximum value of Detects 13.4 Median value of Detects 1.29 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # Sam pies Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % Samples w/ Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data Notes Cancer: Disinfection By-Product Value 38 13 0.38 1.20E-06 18,700 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation. Note: may hydrolyze ------- Bromoethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 469 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Bromoethane 2612 74964 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 WHO LD50 Value 1,350 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg mgJkg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 3 7 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data WHO CICAD 42 2002, LD50 1350 mg/kg/day Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N ug/L ug/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Bromoethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 470 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent; refrigerant; fumigant; medication (HSDB) Value 40 days 179 1.61 0.00741 9,000 43 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DSA Notes DSA = Degrades s ow with acclimation ------- Butanenitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 471 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Butanenitrile 4791 109740 Attribute Scores 3-model Categorical Prediction Potency Severity 7 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 28 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg mg/kg mg/kg Date 1996 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 3 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, RJ. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 609 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butanenitrile CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 472 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 15 days 46 0.53 5.23E-05 33,000 43 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Butyl benzyl phthalate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 473 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Butyl benzyl phthalate 3168 85687 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.2 0.2 1.3 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 1998 2000 Critical Effect Significantly increased liver-to-body weight & liver-to- brain weight ratios Significantly increased liver-to-body weight & liver-to-brain weight ratios Gastrointestinal - changes in structure or function of salivary glands, Kidney, Ureter, Bladder - changes in kidney weight; endocrine - other changes Prevalence Magnitude 7 3 NL HRL Ratio(s) NC HRL/CAL DHS 90%: 23.7 Notes Reference Dose Reference Dose; NTP, 1985; Basis NOAEL 159 mg/kg/day, rat, UF=1000, pancreas (NTP, 1985) Reference Dose Reference Dose; NTP, 1985; Basis NOAEL/LEL, rat, liver, brain, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Basis = BMD 132 mg/kd/day, UF = 100, rat (Hammond et al 1987) Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year 14,513,2000 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification C 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1988 Vol. 73, 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 1,400 Y/N Y/N mg/L ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butyl benzyl phthalate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 474 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites/ Samples 851 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 24 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 2.82 Minimum value of Detects Units States States States Minimum value of Detects 0.004 Non-cancer: 23.7 Amount Range 100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 124 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.2 90% of Detects 59 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermed ate; plasticizer (HSDB) Value 9,359 4.73 1.26E-06 2.69 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Butyric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 475 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Butyric acid 4649 107926 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 8,790 2,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 8 5 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Budavari, S. (ed.). 1989. The Merck Index - Encycopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., p. 243. 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1 982 Volume(issue)/page/year -,30,1 982 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butyric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 476 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 100M-500M 100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; food additve; varnish manufacture (HSDB) Value 64 0.79 5.35E-07 60,000 sr Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Butyric anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 477 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Butyric anhydride 4521 106310 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 8,790 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 8 7 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issueypage/year -,321, 1986; Ratstudy Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Butyric anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 478 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 1.39 0.000111 4,560 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- C.I. Acid Red 114, disodium sal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 479 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Acid Red 114, disodium salt 18026 6459945 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 8 120 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Decreased body weight gain shortened lifespan at higher doses. Clear evidence of carcinogenicity in male and female rats (mice not tested) Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Prevalence Magnitude 1 10 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP Report 405 Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP-TR- 405,1991 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Vol.57, 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 56 Y/N Y/N ug/L ug/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- C.I. Acid Red 114, disodium sal CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 480 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Textile dye (HSDB) Value 180 7.86 5.05E-31 2.50E-06 54 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades slow/recalcitrant (PBT) ------- C.I. Direct Blue 15 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 481 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Direct Blue 15 13296 2429745 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 45 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 22 month study: decreased surviva Prevalence Magnitude , „ 37 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; NTP; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/pagefyear NTP-TR-397,1992 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 105 Y/N Y/N ug/L ug/L EPA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- C.I. Direct Blue 15 CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 482 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life K0c« Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Notes ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye; biological stain (HSDB) Value 136,000,000 0.71 8.56E-44 0.0059 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- C.I. Direct Blue 218 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 483 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Direct Blue 21 8 30455 28407376 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 40 500 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1994 Critical Effect Squamous and basal hyperplasia of the forestomach - clear evidence of cancer in male and female mice, some evidence in male rats and no evidence in female rats Liver - other changes, Kidney, Ureter, Bladder - changes in bladder weight, Blood - pigmented or nucleated red blood cells Prevalence Magnitude ,,, 23 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-430,1994 Lowest Observed Adverse Effect Level; oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR- 430,1994 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 280 Y/N Y/N ug/L ug/L CACART; clear evidence of cancer in male and female mice, some evidence in male rats and no evidence in female rats (NTP) Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- C.I. Direct Blue 218 CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 484 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 2,609 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 140 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Textile dye (HSDB) Value 180 54 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades slow/recalcitrant (PBT) ------- C.I. Disperse Yellow 3 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 485 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Disperse Yellow 3 13973 2832408 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Decreased weight gain throughout the study; a dose related increase in renal pigmentation was observed in the females- Cancer was positive for male rats and female mice and negative for female rats and male mice Prevalence Magnitude 1 1 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; NTP; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year NTP- TR-222,1982 Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Vol. 48, 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 933 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- C.I. Disperse Yellow 3 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 486 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2002 2002 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Textile dye (HSDB) Value 60 3.98 1.50E-11 1.18 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades slow/recalcitrant (PBT) ------- C.I. Pigment Red 53, barium sal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 487 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Pigment Red 53, barium salt (2:1) 16485 5160021 Attribute Scores Potency Severity 5 5 Prevalence Magnitude 5 ncomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Haematological effects; spleen, kidney, and liver effects- unspecified. 3-model Categorical Prediction HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; SIDS Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.005 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Vol.57, 1993 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 58.3 Y/N Y/N ug/L ug/L CACART; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- C.I. Pigment Red 53, barium sal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 488 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in paints and inks (HSDB) Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- C.I. Solvent Yellow 14 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 489 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): C.I. Solvent Yellow 14 9896 842079 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date Critical Effect Cardiac valve fibrosis. Nephropathy, Atrophy of pancreatic acinus Prevalence Magnitude ,,, _ 1 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; NTP; Study Report TR-226 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Vol. 8, Suppl. 7, 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 46.7 Y/N Y/N ug/L ug/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- C.I. Solvent Yellow 14 CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 490 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye for organic so utions (HSDB) Value 38 5.51 2.62E-11 0.674 5 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades with acclimation (PBT) ------- Calcium carbonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 491 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Calcium carbonate 7087 471341 Attribute Scores 3-model Categorical Prediction Potency Severity 1 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 60,000 6,450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1972 Critical Effect Gastrointestinal - hypermotility, diarrhea, Gastrointestinal - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 7 NL HRL Ratio(s) NC HRL/CAL DHS 90%: 0.36 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; EPASR United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year#86940001000,1994 Supplemental Data 28ZPAK"SbornikVysledkuToxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., InstitutPro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year -, 267, 1972 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140,000 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Calcium carbonate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 492 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites/ Samples 11,848 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 11,811 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 99.7 Minimum value of Detects Units States States States Minimum value of Detects 100 Non-cancer: 0.36 Amount Range >10M-50M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 426,000,000 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 158,000 90% of Detects 389,000 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Antacid; food additive; pesticide; chemical intermed ate (HSDB) Value In sol. Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Calcium hydroxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 493 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Calcium hydroxide 11051 1305620 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 7,300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mgflsg Date 1981 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 10 HRL Ratio(s) No HRL/No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1 -1 1, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volumefissuej/page/year 32,1477,1981 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Calcium hydroxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 494 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; lubricant; veterinary medication; chemical intermediate (HSDB) Value 1,730 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/reca citrant ------- Calcium octadecanoate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 495 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Calcium octadecanoate 11834 1592230 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mgfltg Date 1992 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 85 L' HRL Ratio(s) No HRL/No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 36(4),17,1992 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Calcium octadecanoate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 496 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer stabilizer; food additive; waterproofing (HSDB) Value 38 40 2 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Caprolactam CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 497 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Caprolactam 4466 105602 Attribute Scores Potency Severity 3 7 Prevalence Magnitude 10 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 0.5 482 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Reduced offspring body weight Reduced offspring body weight Nutritional and Gross Metabolic - weight loss or decreased weight gain 3-model Categorical Prediction L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Serotta etal., 1984 Basis NOAEL 50 mgflsgWay, rat, UF=100 Reference Dose Reference Dose; Serotta et al., 1984; Basis NOAEL/LOAEL, rat, UF=100, MF = 1 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0555505 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 4 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Vol. 39, Suppl. 7; Vol. 71; 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N ug/L ug/L Teratogen IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- Caprolactam CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 498 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life KOC. Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n polymer synthes s (HSDB) Value 57.4 0.66 2.52E-08 772,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Carbaryl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 499 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Carbaryl 2448 63252 Attribute Scores Potency Severity 3 8 Prevalence Magnitude 1 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 0.1 0.01 0.1 0.008 0.23 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 2006 1975 Critical Effect Plasma & brain ChE inhibition. Q1* 0.000875 (mg/kg-day)- 1 - Likely. Kidney; liver mmunological Includ ng Allergic - decrease in humoral immune response 3-model Categorical Prediction NL-NL? HRL Ratio(s) NCHRL/NCODR290%:70 CAR HRL/NCOD R2 90% : 40 Notes Reference Dose Reference Dose; Carpenter et a ., 1961; Basis NOAEL9.6 mg/kg/day, rat, UF=100, kidney & liver Reference Dose Reference Dose; Carpenter et a ., 1961; Basis NOAEL/LOAEL, rat, UF=100, kidney & liver Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; ora Pharmacology. (Academic Press, Inc., 1 E. Volume(issue)/paqe/year32,587,1975 study in rabbit; TXAPA9 Toxicology and Applied First St., Duluth, MN 55802) V.1- 1959- Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.000875 Likely to be carcinogenic in humans 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mgflsg-d)-1 2003 2007 incidence of hemangiosarcomas in mice 2002 and 2007 Carbaryl Occupational Risk Assessment in August 2008 Amended RED 2003 and 2007 Carbaryl Occupational Risk Assessment in August 2008 Amended RED Vol. 12, Suppl. 7, 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW MAC Y 0.4 70 40 0.09 Y/N Y/N mg/L ug/L ug/L mg/L 2006 Teratogen EPA; IARC UMD Drinking Water Equivalent Level Canadian Drink ng Water Maximum Allowable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Carbaryl EPA-OGWDW August 2009 CCL 3 Contaminant Information Sheet Page 500 of 1 124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,679 13 0.103 0.18 3 0.18 1 3 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratio (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,142 85 # Sam pies 85 Amount Released 4,857,542 25 3,475 # PWSs/Sites/ Samples 0.296 0.550 4,671 697 14 #with Detects 14 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2 0 1 9.76 16.5 % Samples with detects 17 0.12 Number of States 48 3 7 % PWSs/Sites/ Samples with detects 0.9 0 0.02 0.0005 Minimum value of Detects Units States States States Minimum value of Detects 3.5 Non-cancer: 70 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 33.5 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.041 Not Detected 3.5 0.0167 0.04 Median value of Detects 0.17 0.9 0.138 90% of Detects 1.2 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 3.5 90% of Detects 3.5 Units for Mag data ug/L ug/L ug/L ug/L ug/L Cancer: 40 Notes Pesticide Data Program (USDA); 2001 Pesticide Data Program (USDA); 2002 Pesticide Pilot Mentoring Program (USGS/EPA) 2001 (GCMS) Pesticide Pilot Mentoring Program (USGS/EPA) 9060 (HPLC/MS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Insecticide; veter nary medication (HSDB) Value 38 242 2.36 4.36E-09 110 18 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation ------- Carbendazim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 501 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Carbendazim 21347 10605217 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.588 2,500 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 1989 1991 Critical Effect Liver effects: hepatic cirrhosis, swollen, vacuolated hepatic cells, & mild chronic hepatitis Brain and Coverings - other degeneratve changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; TXCYAC Toxicology. (Elsevier Scientific Pub. reland, Ltd., POB85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year 57,173,1989 Supplemental Data Dog; PEMNDP Pesticide Manua . (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR47QG, UK) V.1- 1968- Vo ume(issue)/page/year 9,123,1991 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Carbendazim CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 502 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide (HSDB) Value >35days 350 2.10E-11 33 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DS Notes DS = Degrades slow (HSDB) ------- Carbon disulfide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 503 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Carbon disulfide 2629 75150 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 139 1,200 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1966 Critical Effect Fetal toxicity/malformations Fetal toxicity/malformations Cardiac - changes in heart weight, Endocrine - hyperglycemia, Immunological Including Allergic - decrease in cellular immune response Details of toxic effects not reported other than lethal dose value Prevalence Magnitude .,, „ 10 3 NL!'L! HRL Ratio(s) NC HRL/NAWQA 90%: 5,426 Notes Reference Dose Reference Dose; Basis NOEL = 1 1 mg/kg-d, rabbit, oral, UF = 1 00 (Hardin et al., 1 981 ) Reference Dose Reference Dose; Basis NOEL, MF= 1, UF = 100, rabbit (Hardin et al., 1981) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rabbit; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 31 (1 ), 1 3, 1 966 Supplemental Data INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- Volume(issue)/page/year 32,145,1994 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 700 Y/N Y/N ug/L ug/L Developmental (male & female); Teratogen CACART; UMD CACART; UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Carbon disulfide CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 504 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,606 # Sam pies Amount Released 6,902 26,946,784 # PWSs/Sites/ Samples 1,075 606 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 4 23.3 % Samples with detects Number of States 11 32 % PWSs/Sites/ Samples with detects 0.37 0.001 Minimum value of Detects Units States States States Minimum value of Detects 0.55 Non-cancer: 5,426 Amount Range >100-500M >10-50M Units Ibs/yr Ibs/yr Year 1998 2002 34 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 34 0.02 Median value of Detects 0.129 90% of Detects 3.4 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 14.4 90% of Detects 29.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former insecticide/fumigant; rubber additive; industria solvent; chemical intermediate (HSDB) Value 1 1.94 0.0144 1,180 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS =Biodegrades s ow (BIODEG) ------- Catechol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 505 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Catechol 5350 120809 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 65 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Blood -changes in serum composition (e.g. TP, bilirubin, cholesterol) IARC say that it causes hyperplacia of the fore stomach and pyloric mucosa which is consistent with the cancer response but does not identify the study or dose. Prevalence Magnitude ,,, _ 10 6 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nfshi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 Volume(issue)/page/y ear 29,180,2001 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 152 Y/N Y/N ug/L ug/L IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Catechol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 506 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 26,494 35,91 1 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 25 30 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical antiox dant; chemical intermediate for insecticides and PPCPs (HSDB) Value 118 0.88 1.20E-09 461,000 37 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- CFC-11 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 507 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): CFC-1 1 2673 75694 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 0.3 0.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Survival & histopathology. Increased mortality, incidence of pleuritis & pericalditis Survival & histopathoogy Prevalence Magnitude , „ , 8 7 Li L HRL Ratio(s) NC HRL/NCOD R1 90%: 247 Notes Reference Dose Reference Dose; Basis LOAEL = 488 mg/kg-d, Adjusted Basis LOAEL = 349 mg/kg-d, UF = 1 000, rat, oral (NCI, 1978) Reference Dose Reference Dose; Basis LOAEL, MF = 1, UF = 1000, rat& mouse (NCI, 1978) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 10 2,100 Y/N Y/N mg/L ug/L ug/L EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- CFC-11 CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 508 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,851 23,341 249 265 1.48 1.14 0.01 0.0014 1,444 105 1.3 0.85 8.5 5 72 24.9 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,340 # Sam pies Amount Released 54 266,643 # PWSs/Sites/ Samples 12,179 104 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 51 2.4 % Samples with detects Number of States 3 13 % PWSs/Sites/ Sam pies with detects 0.42 0.007 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Non-cancer: 247 Amount Range 100M-500M 50M-100M Units Ibs/yr Ibs/yr Year 1990 1994 24 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 46 0.143 Median value of Detects 1.1 90% of Detects 17 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1.8 90% of Detects 13.4 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; chemical intermediate; in fire extinguishers; in insulation blowing; in aerosols - major uses now phased out (HSDB); gas Value 48.6 2.53 0.0971 1,100 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- CFG-12 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 509 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): CFC-12 2674 75718 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.2 0.2 14 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Reduced body weight Reduced body weight Behavioral - alteration of classical conditioning, Blood - changes in erythrocyte (RBC) count, Bochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Prevalence Magnitude 8 7 NLi HRL Ratio(s) NC HRL/NCOD R1 90%: 77.8 Notes Reference Dose Reference Dose; Basis NOAEL = 15 mg/kg-d, rat, UF = 100, oral (Sherman, 1974) Reference Dose Reference Dose; Basis NOAEL/LOAEL, MF = 1, UF = 100, rat, whole body (Sherman, 1974) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 52(3), 73,1 987 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5 1,400 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- CFG-12 CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 51 Oof 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,076 22,145 221 285 1.37 1.29 0.1 0.1 405 230 2 1.22 18 8 200 27.7 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,341 # Sam pies Amount Released 10 224,225 n PWSs/Sites/Sa mples 12,205 108 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 271 2.49 % Samples with detects Number of States 2 15 /O PWSs/Sites/Sam pies with detects 2.22 0.01 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Non-cancer: 77.8 Amount Range 100M-500M 100M-500M Units Ibs/yr Ibs/yr Year 1990 1994 38 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 160 0.2 Median value of Detects 0.6 90% of Detects 4.3 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2.4 90% of Detects 6.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; n insulation blowing; in aerosols - major uses now phased out (HSDB); gas Value 38 days 48.6 2.16 0.343 280 48 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Chloral Hydrate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 511 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Chloral Hydrate 6463 302170 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 1 Units mg/kg-d mg/Kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 Critical Effect CNS depression and Gl irritation Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) DSSTOX TD50 EPA Carcinogen classification ARC Carcinogen Classification 106 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 mg/kg-d 1995 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N mg/L W/L W/L Prevalence Magnitude 10 8 Li HRL Ratio(s) NCHRL/DBPICR90%: 58.3 Notes Reference Dose Reference Dose; basis LOAEL - 10.7 mg/kg-d, UF = 100, oral human study; Goodman and Oilman, 1985. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Supplemental Data Tumorigenic Dose - 50 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chloral Hydrate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 512 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 10,911 #with Detects 7,913 % PWSs/Sites with detects 72.5 Mean value of Detects 5.47 Maximum value of Detects 92.2 Median value of Detects 4 90% of Detects 12 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, etal., 2006 HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 75 Units States States States Minimum value of Detects Non-cancer: 58.3 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 16 Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 1 90% of Detects Units for Mag data ug/L Notes Finished drinking water monitoring; Krasner, et a/, 2006. Env.Sc/. Techno!. , 40, pp 71 75-71 85 (and related documentation). Cancer: Sedative; hypnotc; in organic synthesis (HSDB) Value 38 82 0.99 5.71 E-09 793,000 41 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Chlorendicacid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 513 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chlorendic acid 5103 115286 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL-NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.091 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 1990 Vol. 48 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.385 Y/N Y/N W/L W/L CACART; IARC; OEHHA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorendicacid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 514 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K - 1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame retardant in textiles and building materials (HSDB) Value 180 days 49 2.3 3.00E-14 6 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Chlorethoxyfos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 515 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chlorethoxyfos 36627 54593838 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0006 0.0495 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d 1996 mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma, RBC, and/or Brain ChE inhibition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Behavioral - somnolence (general depressed activity), Behavioral - food intake (animal), Gastrointestinal - changes in structure or function of salivary glands Prevalence Magnitude , „ 7 5 L' HRL Ratio(s) NC HRL/SW Chronic EEC: 52.5 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data TOXID9Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year30,124,1996 Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0536238 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4.2 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorethoxyfos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 516 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 252,792 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 10 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 Surface water chronic: 0.08 ug/L Non-cancer: 52.5 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 0.002 ug/L Cancer: nsecticide (HSDB) Value 4.3-59 days 890 4.20E-06 5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DST Notes DST = Degrades sometimes/recalcitrant (HSDB) ------- Ch loroacetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 517 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Chloroacetaldehyde 4598 107200 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) DSSTOX TD50 EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification 36.1 LM mg/L (mg/kg-d)-1 (mg/kg-d)-1 mg/kg-d Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L W/L W/L Prevalence Magnitude 10 5 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Tumorigenic Dose - 50 DSSTOX; LM = Low to medium probability of being carcinogenic DSSTOX Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ch loroacetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 518 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Krasner, et al. HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % PWSs/Sites/Sam pies with detects 50 Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 2.4 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0,2 90% of Detects Units for Mag data ug/L Notes Finished drinking water monitoring; Krasner, eta/, 2006. Env. Sci. Technol. , 40, pp 7175-7185 (and related documentation). Cancer: Disinfection By-Product Value 15 39 0.39 2.39E-05 111,000 45 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades Slow ------- Chloroacetyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 519 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloroacetyl chloride 2856 79049 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Supplemental Lowest Oral LD50 Value 208 207 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg mg/kg Date 1991 Critical Effect Weakness and collapse; effects on ungs liver and gastrointestinal tract on necropsy Prevalence Magnitude , „ 85 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat (American Conference of Governmental Industril Hygeinists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. OPPTS; Monsanto study 1992 OST0536760 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 14.5 Y/N Y/N W/L W/L UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Chloroacetyl chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 520 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data N AWQA ambient water MREC ambient surface water MREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,fl, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; tear gas (HSDB) Value 4 -0.22 0.00023 43 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Chlorobenzilate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 521 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chlorobenzilate 7384 510156 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 0.02 35.3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 1980 1972 Critical Effect Decreased food intake, weight gain, stool quantity, and hyperirritablility mmunological Includ ng Allergic - decrease in cellular immune response 3-model Categorical Prediction NL-NL? HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose; Basis NOEL = 5 mg/kg-d, rabbit, oral (Ciba-Geigy, 1984a) Reference Dose Reference Dose; Basis NOEL/LEL, MF = 1, UF = 300, rabbit (Ciba-Geigy Corp., 1984) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 17-week oral study in rat; FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.2- 1939- Vo ume(issue)/page/year 35(3), 352,1972 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.27 0.11 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 Vol. 30, Suppl. 7, 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 140 0.318 Y/N Y/N W/L W/L CACART; IARC; OEHHA; RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorobenzilate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 522 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 5 n PWSs/Sites/Sa mples 117 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 0 1 % PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide (HSDB) Value 1,263 4.74 7.24E-08 13 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Chloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 523 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloroethane 2616 75003 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 4 7 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol. 52, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L CACART; Equivocal evidence of carcinogenicity in male and female rats; clear evidence in female mice; nadequate study in male mice (NTP). Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chloroethane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 524 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,236 24,433 78 84 0.385 0.344 0.10 0 112 288 1.00 1.30 9.7 6.85 64 84.5 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,271 # Sam pies Amount Released 586 732,853 n PWSs/Sites/Sa mples 11,930 39 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 44 0.913 % Samples with detects Number of States 5 15 % PWSs/Sites/Sam pies with detects 0.37 0.0175 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 40 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 46 0.06 Median value of Detects 1 90% of Detects 40 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1.3 90% of Detects 2.3 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermed ate; solvent; refrigerant; medication (HSDB); gas Value 23.7 1.43 0.0111 6.71 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Chloromethyl methyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 525 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloromethyl methyl ether 4605 107302 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 2 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL? - L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2A A 1 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 1988 Oral Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.0146 Y/N Y/N W/L W/L EPA; UMD; IARC;OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chloromethyl methyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 526 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 1,085 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 2.38 0.32 0.000303 69,400 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Chlorophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 527 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chlorophenol 28429 25167800 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.003 570 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 Critical Effect Reproductive effects - Ortho isomer mmune system- Rat Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 66 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Basis NOAEL = 0.3 mg/kg-d, rat, UF = 100, oral (Exon and Koller, 1985) Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat, oral; BSLIB Biochemistry Section, Laboratory Investigations Branch, DRDS, ALOSH, NIOSH Volume(issue)/page/year -,1,1979 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 528 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 76 43,439 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; disinfectant; veterinary med cation (HSDB - uses for 2-chloropheno , 3-chlorophenol and 4-chlorophenol) Value 15 days 2.16 4.15E-07 28,500 29 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Chloropicrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 529 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloropicrin 2704 76062 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 32 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1965 Critical Effect Gastrointestinal - other changes, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 10 6 NLi HRL Ratio(s) NC HRL/DBP ICR 90% : 93.4 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; (DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year 17,125,1994) Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 74.7 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chloropicrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 530 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR # PWSs/Sites sampled 10,905 #with Detects 2,837 % PWSs/Sites with detects 26.02 Mean value of Detects 1 Maximum value of Detects 13.6 Median value of Detects 0.8 90% of Detects 1.61 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Supplemental Water Data Krasner, et al. HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 13,882,188 0 14,865 n PWSs/Sites/Sa mples 4 # PWSs/Sites sampled 12 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 #with Detects 6 % Samples with detects Number of States 29 0 8 % PWSs/Sites/Sam pies with detects 25 % PWSs/Sites with detects 50 Minimum value of Detects Units States States States Minimum value of Detects 0.5 Minimum value of Detects Non-cancer: 93.4 Amount Range 1M-10M Units Ibs/yr Ibs/yr Year 1986 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 1.5 Maximum value of Detects 2 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Notes Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1 Median value of Detects 0.2 99% of Detects 1.4 75% of Detects 0.4 Units for Mag data ug/L Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Notes Finished drinking water monitoring; Krasner, et al, 2006. Env. Sci. Techno!. , 40, pp 71 75-71 85 (and related documentation). Rodenticide; fumgant; tear gas (HSDB) Value 81 2.09 0.00205 1,621 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Chloroprene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 531 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chloroprene 5636 126998 Attribute Scores 3-model Categorical Prediction Potency Severity 5 2 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.05 Units mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1980 Critical Effect Alopecia Liver - changes in liver weight, Endocrine - changes in spleen weight, Biochemical - Enzyme nhibition, induction, or change in blood or tissue levels - dehydrogenases Prevalence Magnitude ,,, „ 3 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis NOAEL, MF = 1 , hair, rat, UF = 1 00 (USEPA, 1 989). Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 45(2), 17,1 980 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 140 Y/N Y/N W/L W/L CACART; IARC CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chloroprene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 532 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 74 925,010 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in adhesives (HSDB) Value 15 days 67.7 2.53 0.056 875 74 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Chlorothalonil CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 533 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Chlorothalonil 12375 1897456 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.015 0.015 0.015 0.03 1.5 75 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1994 1990 Critical Effect Increased kidney weights & hyperplasia of the proximal convoluted tubules in the kidneys, ulcers & forestomach hyperplasia. Q1 * 0.00766 (mg/kg-day)-1 . Group B2. See CAR Renal tubular epithel al vacuolation Tubular epithelial vacuolation Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Kidney, Ureter, Bladder - changes in bladder weight Prevalence Magnitude ,,, „ 4 4 HRL Ratio(s) NCHRL/NAWQA90%: 342 CAR HRL/NAWQA 90% : 3.66 Notes Reference Dose Reference Dose; Basis NOEL =1.5 mg/kg/day, UF = 100, kidney, dog, oral (Diamod Shamrock Chemical, 1970a) Reference Dose Reference Dose; Basis NOEL/LEL, MF = 1, kidney, dog, UF = 100 (Diamod Shamrock Chemical, 1970) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; OPP RfD No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 53,155,1990 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* EPA Lifetime Cancer Risk, 1CT5 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.15 0.5 0.011 0.0031 0.00766 B2 2B mg/L mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1999 Corresponds with OPP slope factor. OPP Vol. 73, 1999; note: OEHHA lists lARCs cancer class as 3. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.5 140 1.5 Y/N Y/N mg/L W/L W/L CACART; IARC; EPA; OEHHA; RAIS CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Chlorothalonil CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 534 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS POP PPMP PPMP HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,547 # Sam pies Amount Released 11,916,713 6 303,181 n PWSs/Sites/Sa mples 4,099 29 15 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 0 0.33 % Samples with detects Number of States 48 2 7 % PWSs/Sites/Sam pies with detects 0 0.007 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Not Detected Not Detected Not Detected Non-cancer: 342 Amount Range Fungicide; bacter Value 2,392 3.05 2.00E-06 0.6 Units Ibs/yr Ibs/yr Year 1998 2002 0.71 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Not Detected Not Detected 0.05 Median value of Detects 0.41 90% of Detects 0.71 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected Not Detected Not Detected Not Detected 90% of Detects Not Detected Not Detected Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L Cancer: 3.66 Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide Data Program (USDA) Pesticide Pilot Monitoring Program (USGS/EPA) Ambient (HPLC/MS) Pesticide Pilot Monitoring Program (USGS/EPA) Finished (HPLC/MS) ocide (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cinnamaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 535 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cinnamaldehyde 4388 104552 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 550 0.208 1,160 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 Critical Effect Slight decrease in body weight Liver - changes in liver weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.), Related to Chronic Data - death Behavioral - coma Prevalence Magnitude ,,, 5 7 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Journal; Bickers, et al. Food and Chemical Toxicology 43 (2005) 799-836 Lowest Observed Adverse Effect Level; 24-week oral study in rat; BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year 49,306,1992 Supplemental Data FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year 2,327,1964 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3,850 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cinnamaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 536 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; attractant in insect control (HSDB) Value 1 5 days 0.19 1,420 33 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Citric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 537 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Citric acid 2776 77929 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 620 3,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 85 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Maximum Recommended Da ly Dose (MRDD); MRDDs were only used for screening, not for attribute scoring. No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O MezhdunarodnayaKniga, 113095 Moscow, USSR) V,1- 1936- Volume(issueXpage/y ear -,65,1993 Supplemental Data OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 1 80, Sendai 980-91 , Japan) V.1- 1967- Voume(issue)/page/year 43,561, 1992 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,447 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Citric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 538 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; medication; pesticde (HSDB) Value 3.1 -1.64 4.30E-14 383,000 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Clomazone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 539 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Clomazone 66450 81777891 Attribute Scores 3-model Categorical Prediction Potency Severity 3 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.84 1,369 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Hydronephrotic kidneys in male offspring, decreased body weight, decreased pup weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 7 Li HRL Ratio(s) NC HRL/ SW Chronic EEC: 256 Notes Reference Dose; TRED Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year 9,178,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5,880 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Clomazone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 540 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 2,531,160 OPP Estimated Environmental Concentration HRL Ratios (HRL/ SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 36 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 23 ug/L Non-cancer: 256 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 2.4 ug/L Cancer: Herbicide (HSDB) Value 60-573 2.5 4.13E-08 1,100 18 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Co bait compounds CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 541 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cobalt compounds 38 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 72 150 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect decreased fertility and preimplantation loss Prevalence Magnitude 10 10 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Journal; Pedogo and Vernon 1993; Chemical tested forthe supplemental LOAEL was CoCI2. Speijers, G., et al; Food Chem Toxicol., 20(3): 311-314. Rat study Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 168 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Co bait compounds CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 542 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 86,313 6,910,811 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 30 45 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additives as drying agents; glass additives; catalysis (HSDB) Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- Coumarin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 543 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Coumarin 3492 91645 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 16 1.67 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg mg/kg mg/kg Date 1956/1982 2006 Critical Effect Liver -jaundice, other or unclassified, Blood - hemorrhage, Related to Chronic Data - death; Liver - hepatitis (hepatocellular necrosis), diffuse, Liver - iver function tests impaired, Blood - changes in platelet count Hepatotoxicity; liver effects. Prevalence Magnitude ,,, „ 5 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake No Observed Effect Level (2006) Supplemental Data (2006) Lowest Observed Adverse Effect Level from two studies: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 118,348,1956. NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0555582. Supplemental Data; Journal; Food and Chemical Toxicology 44 (2006) 462-475 Supplemental Data; Maximum Recommended Da ly Dose (MRDD) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 37.3 Y/N Y/N W/L W/L Teratogen IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Coumarin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 544 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; former food additive (suspended 1954); in PPCPs (HSDB) Value 140 1.39 9.90E-08 1,900 38 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cresol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 545 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cresol 11192 108394 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 256 760 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date Critical Effect Increased absolute and relative liver weight Prevalence Magnitude 10 9 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; NTP; NTP Tox-09 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 597 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cresol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 546 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 61,486 1,475,929 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 23 35 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; chemical intermediate; degreaser; veterinary medicaton (HSDB) Value 22 1.95 1.20E-06 25,900 32 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cryolite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 547 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cryolite 24566 15096523 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 23.1 95 5,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - food intake (animal), Liver - other changes, Kidney, Ureter, Bladder - other changes Increases in emesis, nucleated cells in males, renal lesions, and a decrease in urine specific gravity. Gastrointestinal - changes in structure or function of salivary glands, Skin and Appendages - hair Prevalence Magnitude , „ 87 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; BGTOX BG Chemie Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. (Springer- Verlag New York, POB 2485, Secaucus, NJ 07096). Supplemental Data; EPA OPP (RED) BAYER (Bayer. AG, Institute fur Toxikologie, Wuppertal, Germany) Volume(issue)/page/year #15722,1987 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 222 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cryolite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 548 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,560,365 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 13 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide; industrial electrolyte; medication (HSDB) Value Assumed persistent 250-320 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Cupferron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 549 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cupferron 5877 135206 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude ,,, ,,, „ 1 1 NL NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.22 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.159 Y/N Y/N W/L W/L OEHHA; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cupferron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 550 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Laboratory reagent (HSDB) Value 15 days Freely soluble 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Cure-Rite 18 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 551 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cure-Rite 18 23329 13752517 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 35.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Kidney, Ureter, Bladder -other changes, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 5 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0536514 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 82.7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cure-Rite 18 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 552 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber accelerator (West Coast Polychem.com - manufacturer) Value 38 days 47 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Cyanazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 553 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyanazine 27282 21725462 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 0.985 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 Critical Effect Reduced body weight and body weight gain, increased platelet count, decreased protein, albumin and calcium Behavioral - food intake (animal), Reproductive - Maternal Effects- breasts, lactation (prior to or during pregnancy), Tumorigenic - carcinogenic by RTECS criteria Prevalence Magnitude , „ , 94 L' L HRL Ratio(s) NC HRL/NAWQA 90% : 16.5 CAR HRL/NAWQA 90% : 0.049 Notes Reference Dose Reference Dose Reference Dose Reference Dose; USEPA, 1993; Basis NOEL, dog, UF = 300 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 371 -day oral study in rat; JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year 60,567,2000 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.84 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer WHODWQ CADWIMAC Y Y 0.07 14 0.042 0.6 0.01 Y/N Y/N mg/L W/L W/L W/L mg/L Developmental; Teratogen RAIS CACART; UMD Drinking Water Equivalent Level World Health Organization Drink ng Water Guide Canadian Drink ng Water Interim Maximum Allowable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cyanazine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 554 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,164 # Sam pies Amount Released 20,233,056 0 370 n PWSs/Sites/Sa mples 317 33 590 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 145 3 0 8.24 % Samples with detects Number of States 48 0 1 % PWSs/Sites/Sam pies with detects 44.9 42.1 0 0.002 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: 16.5 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 160 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.332 0.355 Not Detected 0.039 Median value of Detects 0.849 90% of Detects 6.7 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 95% of Detects 0.007 0.128 Not Detected Units for Mag data ug/L ug/L ug/L ug/L Cancer: 0.049 Notes Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Ambient Pesticide Pilot Monitoring Program (USGS/EPA) Finished Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Cancelled herbicide (HSDB) Value 124 2.22 2.96E-12 170 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Cyanogen chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 555 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Cyanogen chloride 7358 506774 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI WHO TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 0.054 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 Critical Effect Weight loss, thyroid effects and myelin degenration Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2 350 Y/N Y/N mg/L W/L W/L Prevalence Magnitude 10 7 Li HRL Ratio(s) NCHRL/DBPICR90%: 43.8 Notes Reference Dose Reference Dose; basis NOAEL = 25.3 mg/kg-d, UF/MF = 500; chronic oral rat study; Howard and Han zal, 1955. Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cyanogen chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 556 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 1,745 #with Detects 1,358 % PWSs/Sites with detects 78 Mean value of Detects 3.69 Maximum value of Detects 21 Median value of Detects 2.7 90% of Detects 8 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # Sam pies Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % Samples w/ Detects Units States States States Minimum value of Detects Non-cancer: 43.8 Amount Range Military gas; warn Value 15 -0.38 2.50E-02 60,000 44 Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data Notes Cancer: ng agent in fumgants; in chemica sysnthesis (HSDB) Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades Slowly ------- Cyanuric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 557 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyanuric acid 4719 108805 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 150 30 3,400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1962 Critical Effect Functional and histopatological effects in the kidney; increases in absolute and relative kidney weights and relative adrenal weights. Kidney, Ureter, Bladder - other changes, Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 8 3 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat; QISAAA Qigiena i Sanitariya. For English translation, see HYSAAV. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 27(1 2),1 3,1 962; The LOAEL was used for Potency scoring because it was lower than the NOEL from other studies. Supplemental Data ZKMAAXZhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year25,345,1985 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyanuric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 558 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100-500M >100-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; laboratory reagent (HSDB) Value 66-124 1.38E-18 2,000 23 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cyanuric chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 559 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyanuric chloride 4716 108770 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 350 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1392 Critical Effect Liver - changes in liver weight, Blood - pigmented or nucleated red blood cells, Related to Chronic Data - death Behavioral - somnolence (general depressed activity), Behavioral - food intake (animal), Nutrtional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude ,,, „ 8 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TOXID9 lexicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue);page;year 12,119,1992; 28 day study in rat Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Vo ume(issue)/page/year 12(81,35,1968 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 233 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cyanuric chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 560 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10M-50M 100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 60 124 4.90E-07 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- Cyclanilide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 561 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyclanilide 69562 113136779 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 21.2 208 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1997 Critical Effect Liver- liverfunction tests impaired, Liver-other changes, Liver - changes in liver weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „, „ , „ 7 5 NL' L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 62,28350,1997 Supplemental Data FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 62,28350,1997 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 49.5 Y/N Y/N W/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyclanilide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 562 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 177,086 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 9 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide; plant growth regulator (HSDB) Value 95 days 194-565 3.25 7.31 E-10 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reclaitrant (HSDB) ------- Cyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 563 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyclohexane 4884 110827 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 813 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg*g Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 10 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NPIRI Raw Material Data Handbook, Vol.1 Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 1801 5) Volume(issueXpage/year 1 ,17,1 974 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 56.9 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyclohexane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 564 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 10,761 4,761 ,999 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 26 49 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Year 1997 2004 2004 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggragate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Value 15 days 160 3.44 0.15 54 Units length of time cm3/g unitless cm3/g atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Cyclohexanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 565 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyclohexanol 4730 108930 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -somnolence (general depressed activity), Lungs, Thorax, or Respiration - other changes, Nutritional and Gross Metabolic -weight loss or decreased weight gain Prevalence Magnitude , „ , 8 10 Li L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS053861 7 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 98 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Cyclohexanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 566 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 9,053 4,538,466 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 3 13 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >500M-1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate (HSDB) Value 13-111 1.23 0.00012 42,000 41 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Cyclohexanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 567 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyclohexanone 4731 108941 Attribute Scores 3-model Categorical Prediction Potency Severity 2 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5 5 0.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1994 Critical Effect Body weight depression Body weight depression Behavioral - alteration of classical conditioning Prevalence Magnitude 10 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Lijinsky and Kovatch, 1986; Basis NOAEL =462 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose; Lijinsky and Kovatch, 1986; Bass NOAEL/LOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year - ,455,1994 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35,000 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyclohexanone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 568 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; degreasing agent; solvent; chem cal intermediate (HSDB) Value 15.2 0.81 9.00E-06 25,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cyclohexylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 569 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyclohexylamine 4729 108918 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.2 97.8 11 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1958 Critical Effect Testicular damage. Testicular atrophy, decreased fertility & live young/litter Testicle Liver - other changes, Kidney, Ureter, Bladder - other changes Behavioral - food intake (animal), Lungs, Thorax, or Respiration - pulmonary emboli, Gastrointestinal - other changes Prevalence Magnitude , „ 67 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Gaunt el al., 1976; Basis NOAEL = 18 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose; Gaunt et al., 1976; Basis NOAEL/LOAEL, rat, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year oral study in rat;VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V. 1-10, 1928-37; V.1- 1955- Volume(issue)/paqe/year 4,659,1958 Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0534836 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,400 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyclohexylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 570 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; boiler water additive; rubber accelerant (HSDB) Value 40.4 1.49 4.16E-06 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Cyfluthrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 571 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyfluthrin 48890 68359375 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 0.025 0.02 300 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Decreased body weights in males, inflam matory foci in kidneys of females Decreased body weights in males, inflammatory foci in kidneys of females Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 10 5 L' HRL Ratio(s) NCHRL/SW Chronic EEC: 1,346 Notes Reference Dose Reference Dose; Mobay Chemical, 1983a; Basis NOEL = 2.5 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose; Mobay Chemical, 1983a; Basis NOEL/LEL, rat, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake; from JECFA evaluation Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 85KYAH "Merck Index; an Encyc opedia of Chem cals, Drugs, and Biologicals", 1 1th ed., Rahway, NJ 07065, Merck&Co., Inc. 1989 Volume(issue)/page/year 11,432,1989 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 175 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyfluthrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 572 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP # Sam pies Amount Released 177,782 0 0 n PWSs/Sites/Sa mples 134 265 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 29 0 0 % PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Surface water chronic: 0.13 ug/L Non-cancer: 1,346 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Finished and Ambient Ground water chronic: 0.00336 ug/L Cancer: nsecticide; medication (HSDB) Value 179,000 5.95 1.50E-10 0.003 1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Cypermethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 573 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cypermethrin 35676 52315078 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.06 0.01 0.01 0.05 25 24.6 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 1996 1985 Critical Effect Clinical signs of neurotoxicity & mortality; decreased body weight £ body weight gain G.I tract disturbances G.I tract mmunological Includ ng Allergic - decrease in cellular immune response, Immunological Including Allergic - decrease in humoral mmune response Behavioral - somnolence (general depressed activity), Behavioral - convulsions or effect on seizure threshold, Gastrointestinal - changes in structure or function of salivary glands Prevalence Magnitude , „ , 10 5 L"L HRL Ratio(s) NC HRL/SW Chronic EEC: 32,308 Notes Reference Dose; ICI Americas, Inc., 1982a Reference Dose; ICI Americas, Inc., 1982a; Basis NOEL = 1 mg/kg-d, dog, UF = 100 Reference Dose Reference Dose; ICI Americas, Inc., 1982a; Basis NOEL/LEL, dog, UF = 100 Minimal Risk Level Acceptable Daily Intake; from JECFA evaluation Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 3-week oral study in rat; ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year 8,305,1985 Supplemental Data JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1- 1980- Volume(issue)/page/year 11,331,1990 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 420 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cypermethrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 574 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP # Sam pies Amount Released 187,991 n PWSs/Sites/Sa mples 134 380 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 29 /O PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Surface water chronic: 0.013 ug/L Non-cancer: 32,308 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L Notes Pesticide Data Program 2001 Pesticide Data Program 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Finished and Ambient Ground water chronic: 0.0036 ug/L Cancer: nsecticide; veter nary medication (HSDB) Value 108,000 6.06 4.21 E-07 0.004 1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Cyromazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 575 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Cyromazine 42395 66215278 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0075 0.0075 0.02 3,387 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Effects on hematocrit & hemoglobin levels Blood Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, ,,, „ 7 3 NL NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Ciba-Qeigy, 1980; Basis NOEL = 0.75 mg/kg-d, dog, UF = 100 Reference Dose Reference Dose; Ciba-Geigy, 1980; Basis NOEL/LEL, dog, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year 9,217,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 52.5 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Cyromazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 576 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 14,297 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide; medication (HSDB) Value 60 days 2,104 0.96 5.65E-14 13,000 44 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Dacthal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 577 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dacthal 12322 1861321 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 0.01 0.01 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Effects on the lungs, liver, kidney (chronic nephropathy), thyroid. Decreased T4 & T3. Centrilobular hepatocyte swelling (hepatocytic hypertrophy) Lungs; liver; kidney; thyroid; eyes Lungs; liver; kidney; thyroid; Prevalence Magnitude ,,, „ 9 2 NL' HRL Ratio(s) NC HRL/NAWQA 90%: 2,800 Notes Reference Dose; ISK Biotech Corp., 1993 Reference Dose; ISK Biotech Corp., 1993; Basis NOAEL = 1 mg/kg-d, rat, UF = 100 Reference Dose; ISK Biotech Corp., 1993; Basis NOAEL/LOAEL, rat, UF = 100 Reference Dose; ISK Biotech Corp., 1993; Basis NOAEL/LOAEL, rat, UF = 101 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 70 Y/N Y/N mg/L W/L W/L 1988 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dacthal CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 578 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 # Sam pies Amount Released 596,723 n PWSs/Sites/Sa mples 288 582 286 445 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 16 8 1 6.25 % Samples with detects Number of States 38 % PWSs/Sites/Sam pies with detects 5 3.5 0.35 0.000004 Minimum value of Detects Units States States States Minimum value of Detects 0.21 Non-cancer: 2,800 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 100 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.014 0.004 0.21 0.003 Median value of Detects 0.025 90% of Detects 1 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.21 95% of Detects 0.002 0.21 Units for Mag data ug/L ug/L ug/L ug/L ug/L Cancer: Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Ambient 2001 (GC/MS) Pesticide Pilot Monitoring Program (USGS/EPA) Finished 2001 (GC/MS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 60 days 283 4.28 2.18E-06 0.5 12 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Dacthal mono di-acid degradate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 579 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dacthal mono/di-acid degradate 79261 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 Scores based on parent HEALTH EFFECTS DATA1 See Dacthal parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Effects on the lungs, liver, kidney (chronic nephropathy), thyroid. Decreased T4 & T3. Centrilobular hepatocyte swelling (hepatocytic hypertrophy) Prevalence Magnitude , „ 97 L HRL Ratio(s) NCHRL/UCMR90%: 11.1 (HRL for parent Dacthal) Notes Reference Dose (for parent, dacthal); ISK Biotech Corp., 1993 Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on data for parent Dacthal 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dacthal mono di-acid degradate CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 580 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,612 171 4.73 1 190 2 6.3 18 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 # Sam pies Amount Released n PWSs/Sites/Sa mples 2,217 445 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 39 6.25 % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 1.76 0.000004 Minimum value of Detects Units States States States Minimum value of Detects 1 Non-cancer: 11.1 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 100 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 13 0.003 Median value of Detects 0.025 90% of Detects 1 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes Analytical method reports mono- and di- as total. (data for parent, dacthal) National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1.9 90% of Detects 5.3 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx HRL for parent Dacthal Degradates of the herbicide dimethyl tetrachloroterephthalate (HSDB) Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Decabromodiphenyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 581 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Decabromodiphenyl ether 10800 1163195 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL-Int JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.007 0.01 10 1 800 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2008 2004 1975, 1994 Critical Effect Neurobehavioral effects Liver - other changes, Kidney, Ureter, Bladder - other changes, Endocrine - changes in thyrod weight (goiter) Prevalence Magnitude , „ , 10 8 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Basis NOEL = 2.2 mg/kg, UF = 300, single-dose gavage in mice. Viberg, et al, 2003. Reference Dose Reference Dose; Kociba et al., 1975; Basis NOAEL, rat, UF=100 Minimal Risk Level-lnt Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day oral study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994. Volume(issue)/page/year - ,316,1994. Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 5 0.0007 Suggestive evidence 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 2008 2008 2008 IRIS IRIS IRIS Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 50 Y/N Y/N W/L W/L EPA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Decabromodiphenyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 582 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,827 953,472 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 9 26 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame retardant; polymer intermediate (HSDB) Value 409,000 12.1 4.45E-08 0.025 1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Decamethylcyclopentasiloxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 583 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Decamethylcyclopentasiloxane 7678 541026 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 24,134 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 8 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information, Volume issue)/page/year OTS0572801 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,689 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Decamethylcyclopentasiloxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 584 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n PPCPs; chemical intermediate; in petroleum processing (HSDB) Value 38 days 16,000 5.2 0.306 0.017 12 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Desethylatrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 585 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Desethylatrazine 17458 6190654 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.018 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Attenuation of preovultory luteinizing hormone (LH) surge, as a biomarker indicative of hypothalmic function disruption Prevalence Magnitude 10 3 HRL Ratio(s) NC HRL/NAWQA 90% : 881 (HRL for parent Atrazine) Notes Reference Dose; evaluation is based on the RfD for parent (Atrazine). Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 126 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on data for parent Atrazine 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Desethylatrazine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 586 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,151 # Sam pies Amount Released n PWSs/Sites/Sa mples 317 154 2,963 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 154 75 203 167 41.4 % Samples with detects Number of States /o PWSs/Sites/Sam pies with detects 48.6 48.7 89 74.6 Not Detected Minimum value of Detects Units States States States Minimum value of Detects 0.0413 0.0413 Non-cancer: 881 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 10 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.19 0.22 0.352 0.267 0.017 Median value of Detects 0.143 90% of Detects 0.738 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 95th % lie value of Detects 0.265 0.201 Units for Mag data ug/L ug/L ug/L ug/L Cancer: Notes 2002 2001 HRL for parent Atrazine Degradation product of atrazine (HSDB) Value 24-30,000 1.51 1.50E-09 3,200 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- Desisopropylatrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 587 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Desisopropylatrazine 10412 1007289 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.018 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Attenuation of preovultory luteinizing hormone (LH) surge, as a biomarker indicative of hypothalmic function disruption Prevalence Magnitude , „ 10 4 L' HRL Ratio(s) NC HRL/NAWQA 90% : 200 (HRL for parent Atrazine) Notes Reference Dose; evaluation is based on the RfD for parent (Atrazine) Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 126 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on data for parent Atrazine 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Desisopropylatrazine CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 588 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 418 # Sam pies Amount Released n PWSs/Sites/Sa mples 317 154 94 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 127 64 250 146 22.5 % Samples with detects Number of States /o PWSs/Sites/Sam pies with detects 40.1 41.6 80.1 64.9 0.003 Minimum value of Detects Units States States States Minimum value of Detects 0.0163 0.0163 Non-cancer: 200 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 3.69 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.0832 0.073 0.386 0.178 0.1 Median value of Detects 0.63 90% of Detects 2.04 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 95% value of Detects 0.195 0.081 Units for Mag data ug/L ug/L ug/L ug/L Cancer: Notes 2002 2001 HRL for parent Atrazine Degradation product of atrazine Value 60 days 1.15 1.16E-09 670 41 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- D-Glucose CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 589 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): D-Glucose 2156 50997 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 714 100 25,800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Increased heart rate; early dumping syndrome Behavioral - coma, Lungs, Thorax, or Respiration - cyanosis, Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude ,,, ,,, „ 95 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Journal -Andrew Ukleja. Feb 2006. "Dumping Syndrome." Practical Gastroenterology. Series 35: Nutrition Issues in Gastroenterology. pp 32-46. (Series Editor: Carol Rees Parrish, RD, MS) Supplemental Data; Maximum Recommended Da ly Dose (MRDD) 85AIAL "Toxicity of Pure Foods," Boyd, E.M., Cleveland, OH, CRC Press, 1973 Volume(issue)/page/year - ,39,1973 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,666 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- D-Glucose CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 590 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; in medical nutrient solutions; chemica ntermediate (HSDB) Value 8.7 days -3.24 1,200,000 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (PBT) ------- Diallyl glycol carbonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 591 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diallyl glycol carbonate 6128 142223 Attribute Scores Potency Severity 4 6 Prevalence Magnitude 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 42.6 279 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Brain and Coverings - recordings from specific areas of CNS, Liver - liver function tests impaired, Kidney, Ureter, Bladder - renal function tests depressed Brain and Coverings - recordings from specific areas of CNS, Behavioral - somnolence (general depressed activity), Lungs, Thorax, or Respiration - other changes 3-model Categorical Prediction NL7-L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year(2),35,1999 Supplemental Data TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year (2), 35, 1999 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 99.4 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diallyl glycol carbonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 592 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Polymer intermec Value 38 days 40 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Diallyldimethylammonium chlorid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 593 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diallyldimethylammonium chloride 18770 7398698 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,000 7,100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1984 Critical Effect Liver -other changes, Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, „ 8 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect level, GTPZAB Qigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 1 13095 Moscow, USSR) V.1 -36, 1957-1992. For publisher information, see MTPEEI Volume(issueXpage/year 28(7),53,1 984; 6 week mammal study Supplemental Data rodent-mouse; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 28(7), 53, 1984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,333 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diallyldimethylammonium chlorid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 594 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >1QOM-500M Polymer intermec Value 1 5 days -2.49 1,000,000 39 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Diazinon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 595 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diazinon 6596 333415 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0002 0.00009 0.0009 0.0002 0.002 0.143 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Plasma CUE inhibition Decreased cholinesterase activity Liver - fatty liver degeneration, Nutritional and Gross Metabolic - weight loss or decreased we ght gain Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQA 90% : 1 3.2 Notes Reference Dose Reference Dose Reference Dose Reference Dose; USEPA, 1984; Basis NOAEL, UF = 100 Minimal Risk Leve ; Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 28-week oral study in rat; BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year 37,501,1986 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW MAC Y 0.003 1.4 0.02 Y/N Y/N mg/L M/L M/L mg/L Teratogen UMD Drinking Water Equivalent Level Canadian Drinking Water Maximum Acceptable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Diazinon CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 596 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life KOC, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,115 85 # Samples Amount Released 918,087 10,287 23,769 n PWSs/Sites/Sa mples 283 658 6,743 815 22 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 1 114 6 11.45 25.9 % Sam pies with detects 4.89 0.49 Number of States 37 2 7 % PWSs/Sites/Sam pies with detects 0.4 0.2 35.3 0.09 0.0009 Minimum value of Detects Units States States States Minimum value of Detects 0.01 0.01 0.01 Non-cancer: 13.2 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 19 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.01 0.01 0.101 507 0.014 0.07 Median value of Detects 0.125 0.18 0.106 90% of Detects 0.63 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.12 90% of Detects 203 95% of Detects 0.002 Cancer: Units for Mag data ug/L ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Ambient Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Che micalcontaminants.aspx Pesticide; veterinary medication (HSDB) Value 38 days 1,337 3.81 1.13E-07 40 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Diazinon oxygen analog CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 597 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diazinon oxygen analog 79205 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 Scores based on parent HEALTH EFFECTS DATA1 See Diazinon Parent Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0002 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma ChE inhibition Prevalence Magnitude ,,, 1 1 NL Scores based on parent HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose (for parent) Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.4 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on data for Parent Diazinon 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diazinon oxygen analog CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 598 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data- FOR DIAZINON PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released n PWSs/Sites/Sa mples 283 664 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 3 % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 0.4 0.5 Minimum value of Detects Units States States States Minimum value of Detects 0.04 0.015 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.04 0.037 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes (Data for parent) National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Cancer: Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Analog of the pestcide diazinon Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dibromoacetonitrile (DBAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 599 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dibromoacetonitrile (DBAN) 14629 3252435 Attribute Scores Potency 5 Severity Prevalence 10 Magnitude 7 3-model Categorical Prediction Incomplete data for scoring HEALTH EFFECTS DATA1 NCHRL/DBPICR90%: 14.7 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification IARC Carcinogen Classification NTP Carcinogen Studies 3 Some evidence - Clear evidence mg/L (mg/kg-d)"1 (mg/kg-d)-1 1999 2008 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 45.5 Y/N Y/N mg/L M/L M/L Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data National Toxicology Program TR-544 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Dibromoacetonitrile (DBAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 600 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBPICR # PWSs/Sites sampled #with Detects % PWSs/Sites with detects 48.6 Mean value of Detects 1.61 Maximum value of Detects 24 Median value of Detects 1.2 90% of Detects 3.1 99% of Detects Ambient Water Occurrence Data N AWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/DBP ICR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # Sam pies Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % Sam pies w/ Detects Units States States States Minimum value of Detects Non-cancer: 14.7 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data Notes Cancer: Disinfection By-Product Value 38 13 0.47 4.06E-07 9,600 48 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation. Note: may hydrolyze ------- Dibromomethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 601 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dibromomethane 2611 74953 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHERfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 11.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect increased carboxyhemoglobin Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases; plasma urea and mild histological changes Prevalence Magnitude 5 7 NLi HRL Ratio(s) NCHRL/NCODR1 90%: 10.9 Notes Reference Dose Reference Dose Reference Dose Reference Dose; USEPA, 1987; Basis NOAEL, UF= 1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 28-day oral study in rat; BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year 41,515,1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dibromomethane CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 602 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 16,549 23,006 60 108 0.363 0.469 0.1 0.00055 21.1 16.2 1.4 1.1 6.4 5.3 21.1 16 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS Krasner, et al. HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,308 # Sam pies Amount Released 0 24,935 n PWSs/Sites/Sa mples 11,883 12 5 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 16 1 0.116 % Samples with detects Number of States 0 4 % PWSs/Sites/Sam pies with detects 0.13 8.33 0.01 Minimum value of Detects Units States States States Minimum value of Detects 0.55 Non-cancer: 10.9 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 0.2 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 14 0.1 Median value of Detects 0.1 90% of Detects 0.2 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.895 ND 90% of Detects 2.45 Units for Mag data ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Finished drinking water monitoring; Krasner, et al, 2006. Env. Sci. Techno!. , 40, pp 71 75-71 85 (and related documentation). Organic synthesis; solvent (HSDB) Value 15 days 23.7 1.7 0.000822 11,900 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slowly ------- Dibutyltin dichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 603 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dibutyltin dichloride 9364 683181 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL-Int JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 2.5 5 0.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2003 1977 Critical Effect depressed humoral response against SRBC mmunological Includ ng Allergic - decrease in humoral immune response Complete resorption of implanted embryos, increased incidence of post implantation loss, cleft jaw, decreased weight gain. Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 ncomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 4-week oral study in rat; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year42,213,1977 Supplemental Data; Toxicol letters 58:347-356, 1991 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,1248,1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dibutyltin dichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 604 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; polymer intermediate; chemical intermediate (HSDB) Value 1.56 92 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dibutyltin oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 605 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dibutyltin oxide 9781 818086 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0,171 44.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1977 Critical Effect Behavioral -alteration of classical conditioning, Blood • normocytic anemia, Blood -changes in erythrocyte (RBC) count Prevalence Magnitude 5 ncomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (VYOMezhdunarodnayaKniga, 113095 Moscow, USSR) V,1- 1936- Volume(issueXpage/year 42(4), 14, 1977, 26-week, rodent-rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.4 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dibutyltin oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 606 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial Chemical (EPA/SRS) Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dichloran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 607 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dichloran 4022 99309 Attribute Scores Potency Severity 5 7 Prevalence Magnitude 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 74.8 1,450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1968 Critical Effect ncreased alkaline phosphatase & cholesterol, increased liver weights, hepatocyte hypertrophy, vacuolar alterations of the brain and spinal cord, prostate atrophy, degeneration of the seminiferous tubules, & hypospermia in the epididymides Liver - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases, Related to Chronic Data - death Details of toxic effects not reported other than lethal dose value 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/SW Chronic EEC: 97.2 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve Pharmacology. (Academic Press, Inc. Volume(issue)/page/year 1 2,31 4,1 968 ; 2 year dog study; TXAPA9 Toxicology and Applied 1 E. First St., Duluth, MN 55802) V.1- 1959- Supplemental Data rodent-guinea pig; PCOC Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year -,343,1966 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 175 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dichloran CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 608 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total CAL DHS # Sam pies Amount Released 188,683 0 0 n PWSs/Sites/Sa mples 11 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 2 0 0 % PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Surface water chronic: 1 .8 ug/L Non-cancer: 97.2 Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 1 .3 ug/L Cancer: Fungicide; in dyes (HSDB) Value 6.3 12 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Dichloroacetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 609 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dichloroacetaldehyde 2854 79027 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification M mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N mg/L W/L W/L Prevalence Magnitude 10 6 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; M = Medium probability of being carcinogenic Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dichloroacetaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 61 Oof 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al. and related documentation HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 12 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 12 Number of States % PWSs/Sites/Sam pies with detects 100 Units States States States Minimum value of Detects ND Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 14 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 1 90% of Detects Units for Mag data ug/L Notes Finished drinking water monitoring; Krasner, et al, 2006. Env. Sci. Technol., 40, pp 71 75-7185 (and related documentation). Cancer: Disinfection By-Product Value 38 4.3 0.27 8.40E-06 140,000 52 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation ------- Dichloroacetonitrile (DCAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 611 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dichloroacetonitrile (DCAN) 14263 3018120 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 1999 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L W/L W/L Teratogen Prevalence Magnitude 10 7 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dichloroacetonitrile (DCAN) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 612 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR # PWSs/Sites sampled #with Detects % PWSs/Sites with detects 70.1 Mean value of Detects 2.59 Maximum value of Detects 24.6 Median value of Detects 1.97 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al. and related documentation HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 12 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 12 Number of States /o PWSs/Sites/Sam pies with detects 100 Units States States States Minimum value of Detects ND Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 12 Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 1 90% of Detects Units for Mag data ug/L Cancer: Notes Finished drinking water monitoring; Krasner, et al, 2006. Env. Sci. Technol., 40, pp 7175-7185 (and related documentation). Disinfection By-Product Value 38 13 0.29 3.79E-06 33,500 51 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation. Note: may hydrolyze ------- Dichloroiodomethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 613 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Dichloroiodomethane 8286 594047 Attribute Scores Potency Severity Prevalence Magnitude 10 5 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification DSSTOX Carcinogen Classification M mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N mg/L W/L W/L 3-model Categorical Prediction HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DSSTOX; M = Medium probability of being carcinogenic Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dichloroiodomethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 614 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Krasner, et al., (and related documentation) HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released n PWSs/Sites/Sa mples 12 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 12 Number of States /o PWSs/Sites/Sam pies with detects 100 Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects 11 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 0.3 90% of Detects Units for Mag data ug/L Notes Finished drinking water monitoring; Krasner, et al, 2006. Env. Sci. Technol., 40, pp 7175-7185 (and related documentation). Cancer: Disinfection By-Product Value 38 2.03 33 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation ------- Dichlorvos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 615 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dichlorvos 2444 62737 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 0.0005 0.0005 0.004 0.625 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 1990 1997 1993 Critical Effect Cholinesterase inhibit on Plasma and RBC ChE inhibition; blood Neurol. Brain and Coverings - other degeneratve changes, Kidney, Ureter, Bladder - urine volume increased, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true Cholinesterase Prevalence Magnitude ,, 1 1 HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose, AMVAC Chemical Corporation, 1990, NOAEL, dog, UF=100; Basis NOAEL = 0.05 mq/kq-d Reference Dose Reference Dose, AMVAC Chemical Corporation, 1990, NOAEL/LOAEL, dog, UF=100 Minimal Risk Level; UF = 100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day dog study; NYZZA3 Nippon Yakuzaishikai Zasshi. Journal of the Japan Pharmaceutical Association. (Nippon Yakuznishikai, 2-1 2-1 5 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1949- Volume(issue)/page/year 26,739,1974 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 1014 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.01 0.29 0.41 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1989 1991 Gl, pancreas, leukemia IRIS NTP, 1986 Vol. 53 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.1 Y/N Y/N W/L W/L Teratogen list EPA, RAISHE, OEHHA, IARC, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dichlorvos CCL 3 Contaminant Information Sheet OCCURRENCE DATAT EPA-OGWDW August 2009 Page 616 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP PPMP CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 264 n PWSs/Sites/Sa mples n PWSs/Sites/Sa mples 107 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 #with Detects % Samples with detects 0 0 Number of States 0 3 /O PWSs/Sites/Sam pies with detects 0 0 % PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Not Detected Not Detected Units States States States Minimum value of Detects 0 0 Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Not Detected Not Detected Year 1997 2004 2004 Maximum value of Detects 0 0 Maximum value of Detects Not Detected Median value of Detects Not Detected Not Detected 90% of Detects Not Detected Not Detected 99% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0 0 Median value of Detects Not Detected 99% of Detects 0 0 90% of Detects Not Detected Units for Mag data ug/L ug/L Units for Mag data ug/L Cancer: Notes Pesticide Pilot Mentoring Program (USGS/EPA) 9002(GC/MS); Ambient Pesticide Pilot Mentoring Program (USGS/EPA)9002(GC/MS); Finished Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Insecticide; veter nary medicine (HSDB) Value <1 -3. 5 days 40.2 1.47 5.75E-07 8,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Dicofol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 617 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dicofol 5106 115322 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0012 0.002 22.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Adrenal effect: Inhibition of adrenal cortical trophic hormone (ACTH), stimulated release of cortisol Related to Chronic Data - death Prevalence Magnitude 10 6 HRL Ratio(s) NCHRL/SW Chronic EEC: 16.8 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; one year dog study; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 2,1342,2001 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 8.4 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dicofol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 618 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS # Sam pies Amount Released 786,805 0 33 n PWSs/Sites/Sa mples 21 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 36 0 2 /O PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Surface water chronic: 0.5 ug/L Non-cancer: 16.8 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.069 ug/L Cancer: nsecticide; (HSDB) Value 10,500 5.02 2.42E-07 0.8 3 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Dicyclopentadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 619 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dicyclopentadiene 2762 77736 Attribute Scores 3-model Categorical Prediction Potency Severity 4 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHERfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 100 1 190 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1986 Critical Effect None observed reproductive/developmental Behavioral - alteration of classical conditioning, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, 0 9 8 NL: HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA, NOEL, rat, UF=1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26 week rat study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year51(2),77,1986 Supplemental Data mouse study; 40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, nc., 1978 Volume(issue)/paqe/year-, 448, 1978 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dicyclopentadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 620 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 5,234 392,668 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 22 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in flame retardants; animal repellant (HSDB) Value 15 days 1,800 3.16 6.26E-02 51.9 75 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Dieldrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 621 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dieldrin 2415 60571 Attribute Scores 3-model Categorical Prediction Potency Severity 8 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 0.00005 0.00005 0.00005 0.0001 0.0001 0.0083 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 2000 1994 2000 1973 Critical Effect rritability, tremors, occasional convulsions. Increased absolute & relative liver weights. Liver parenchyma cell changes including focal proliferation & focal hyperplasia iver iver Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Immunological Including Allergic - decrease in humoral immune response, Biochemical - Metabolism (Intermediary) - other proteins iver Prevalence Magnitude , „ , 36 L' L HRL Ratio(s) NC HRL/NCOD R2 90% : 0.8 CAR HRL/NCOD R2 90% : 4.5 Notes Reference Dose Reference Dose; Walker et al., 1969, Basis NOAEL = 0.005 mg/kg-d, rat, UF=100 Reference Dose Reference Dose, Walker et al., 1969, Basis NOAEL/LOAEL, rat, UF=100 Minimal Risk Level, Walker et al., 1969, Basis NOAEL = 0.005 mg/kg-d, rat, UF=100 Acceptable Daily Intake; combined total Aldrin + Dieldrin; see also Aldrin Acceptable Daily Intake Tolerable Daily Intake; Fitzhugh et al., 1964; Treon & Cleaveland, 1955, Basis LOAEL = 0.025 mg/kg-d; UF = 250; rat and dog study Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13 week rabbit study; BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year 10,42,1973 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10" RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0002 16 16 B2 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 1987 IRIS Vol. 5, Suppl 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.002 0.35 0.002 Y/N Y/N W/L W/L teratogen list CACART; EPA; RAISHE; OEHHA UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dieldrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 622 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 1 1 ,843 21 0.177 0.02 4.4 0.5 4.4 4.4 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP PPMP CAL DHS HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,100 85 # Sam pies Amount Released n PWSs/Sites/Sa mples # Sites 5,212 205 4 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 0 #with Detects 4 2.89 4.70 % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 0.3 0 % Sites with detects 0.08 0.001 Minimum value of Detects Units States States States Minimum value of Detects Minimum value of Detects 0.01 Non-cancer: 0.8 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 5.60 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Maximum value of Detects 7 0.0097 0.180 Median value of Detects 0.034 90% of Detects 2.48 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 0.0225 99% of Detects 90% of Detects 4.91 Units for Mag data ug/L ug/L Units for Mag data ug/L Cancer: 4.5 Notes Pesticide Pilot Mentoring Program (USGS/EPA) Ambient Pesticide Pilot Mentoring Program (USGS/EPA) Finished Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Restricted insecticide (HSDB) Value 10,600 5.2 1.00E-05 0.25 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DST Notes DST = Degrades sometimes/recalcitrant (HSDB) ------- Diethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 623 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethanolamine 4937 111422 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 10 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect changes in liver and kidney weights 3-model Categorical Prediction L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, NTP information from HSDB, NOAEL Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 2000 Vol. 77 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 624 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 55,403 1,396,761 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 14 29 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Chemical intermed ate; in cutting oi s and PPCPs; in Value 4 -1.43 1,000,000 34 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF/BFA/BSA Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ubricant production (HSDB) Notes BF = Biodegrades fast/BFA = Biodegrades fast with acclimation/BSA = Biodegrades slow with acclimation (BIODEG) ------- Diethyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 625 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethyl sulfate 2468 64675 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 647 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 5 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/pagefyear PB214-270 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1999 Vol. 54, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y Y/N Y/N M8/L W/L Teratogen list IARC, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 626 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 10,644 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1.7 hours 1.14 7,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Chemical intermediate (HSDB) DF = Degrades fast (HSDB) ------- Diethylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 627 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethylbenzene 28613 25340174 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.643 3,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg mg/kg Date 1975 1975 Critical Effect Vascular- regional or general arteriolar or venous dilation, Liver - other changes, Blood - changes in serum composition e.g. TP, bilirubin, cholesterol) Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(6), 90,1 975; 6-wk rabbit study Supplemental Data rabbit study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(6), 90,1975 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.50 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethylbenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 628 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 1 5 days 4.07 0.021 31.9 14 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Diethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 629 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethylene glyco 4941 111466 Attribute Scores 3-model Categorical Prediction Potency Severity 3 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 1,250 375 2,300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1937 Critical Effect Maternal toxicity; increases in absolute and relative kidney weights Related to Chronic Data - death Brain and Coverings - other degeneratve changes, Liver - other changes, Kidney, Ureter, Bladder - other changes Prevalence Magnitude , „ 9 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake; No Severity information available; scored on CTDJPN NOEL. Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP study TER89001 Lowest Observed Adverse Effect Level; 7 week rat study; JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/vear 1 09, 1 51 7, 1 937 Supplemental Data Mouse study; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,145,1984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 8,750 Y/N Y/N W/L W/L teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Diethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 630 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; humectant; antifreeze; in PPCPs (HSDB) Value 1 1.47 2.00E-09 1,000,000 35 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Diethylene glycol monobutyl eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 631 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethylene glyco monobutyl ether 5022 112345 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect hematological effects Prevalence Magnitude „,, „ 8 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, Hobson et al.r 1987, NOAELJADJ, rat, UF=3,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 70 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethylene glycol monobutyl eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 632 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; chemical intermediate; industrial so vent (HSDB) Value 10 0.56 4.45E-11 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Diethylenetriamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 633 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethylenetriamine 4935 111400 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 1,080 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1372 Critical Effect Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -transaminases Behavioral - convulsions or effect on seizure threshold Prevalence Magnitude 8 5 NU HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 37(7),103,1 972, LOAEL, 26 week rabbit study Supplemental Data AMIHABAMA Archives of Industrial Health. (Ch cago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year 17,129,1958 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 23 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethylenetriamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 634 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L u ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; industrial solvent; chelating agent (HSDB) Value -2.13 3.15E-07 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Diethyltoluenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 635 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diethyltoluenediamine 51017 68479981 Attribute Scores Potency Severity 5 5 Prevalence Magnitude 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 472 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Sense Organs and Special Senses (Eye) - lacrimation, Behavioral - somno ence (general depressed activity), Musculoskeletal - other changes 3-model Categorical Prediction NL? HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issuej/page/year OTS0537598, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diethyltoluenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 636 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial Chemical (EPA/SRS) Value 38 days 20 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Difenzoquat methyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 637 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Difenzoquat methyl sulfate 34821 43222486 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 0.08 0.08 25 40 40 206 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1983 Critical Effect Decreased body weight gain Decreased body weight Decreased weight Blood - pigmented or nucleated red blood cells, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Liver - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, „ 8 6 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose, American Cyanamide Co., 1975, Basis NOEL=25 mg/kg-d, rat, UF=300 Reference Dose Reference Dose, American Cyanamide Co., 1975, Basis NOEL, LEL, rat, UF=300 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26 week rat study; KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V. 9- 1966- Volume(issue)/page/year 29(6), 42,1983 Supplemental Data rat study; KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year 29(6), 42,1983 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,400 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Difenzoquat methyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 638 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 346,308 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 11 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (ChemlDPIus) Value 118,000 -0.02 5,553 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Diglycidyl resorcinol ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 639 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diglycidyl resorcinol ether 4212 101906 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 143 12 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Related to Chronic Data - death Decreased survival in males. (Cancer results positive in both sexes mice and rats). Prevalence Magnitude 1 1 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13 week rat study; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/year NTP- TR-257,1986 Supplemental Data; NTP Rep # 257 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 1.7 2B mg/L (mg/kg-d)-1 (mg/kg-d)-' (mg/kg-d)"1 1999 Vol. 36, Suppl. 7; Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 334 0.021 Y/N Y/N W/L W/L OEHHA; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Diglycidyl resorcinol ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 640 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 1 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n resins; rubber additive (HSDB) Value 38 days 1.23 38 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Dimethyl hydrogen phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 641 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyl hydrogen phosphite 9953 868859 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 50 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect noneoplastic lesions of the lungs (rats) - Testicular atrophy in male mice at a dose of 100 mg/kg Clear evidence of cancer in male rats, equivocal evidence in female rats and no evidence in mice Prevalence Magnitude „,, „ 5 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data, NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27T09) No.206- Volume(issue)/page/year NTP-TR-287,1985 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol. 48, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 117 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethyl hydrogen phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 642 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10K-500K XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n lubricants; flame retardant; chemcal intermediate (HSDB) Value 1 9 days >1 00,000 46 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DS Notes DS = Degrades slow (HSDB) ------- Dimethyl laurylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 643 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyl laurylamine 5006 112185 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 740 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 75 L' L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1322 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethyl laurylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 644 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units Cancer: Notes Chemical intermed ate; corrosion nhibitor (HSDB) Value 15 21,700 5.4 0.0049 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Dimethyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 645 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyl sulfate 2767 77781 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 140 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1979 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 5 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GTPZAB Qigiena Truda i Professional' nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 23(3),28,1979 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification B2 2A mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 1988 1999 Vol. 4, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y Y/N Y/N M8/L W/L Teratogen list EPA, IARC, CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethyl sulfate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 646 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 10,221 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 11 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; former war gas (HSDB) Value 1.2 hours 24.2 0.16 4.01 E-06 28,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Dimethyl terephthalate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 647 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyl terephthalate 5339 120616 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 588 125 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 1973 Critical Effect Chronic kidney inflammation kidney; chronic inflammation Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , 0 10 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose, NCI, 1979, Basis LOAEL = 125 mg/kg-d, rat, UF=1,000 Reference Dose Reference Dose, NCI, 1979 , LOAEL, rat, UF=1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 14 week rat study; AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year34,455,1973 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dimethyl terephthalate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 648 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Polymer intermec Value 1 5 days 36.3 2.25 0.000134 19 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Dimethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 649 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethylamine 5570 124403 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0,347 240 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect Behavioral - alteration of classical conditioning, Liver - changesin liver weight, Immunological Including Allergic -decrease in cellular immune response Behavioral - excitement, Behavioral - muscle weakness, Gastrointestinal - ulceration or bleeding from stomach Prevalence Magnitude 10 8 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, QISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/0 Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 32(6), 12,1967, 35 week rat study Supplemental Data rabbit and guinea pig studies; HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year 32(6), 329,1967 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.81 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 650 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 25,286 618,880 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 7 26 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber additive; chemical intermed ate; fuel additive; photographic chemical (HSDB) Value 435 -0.38 49 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Dimethyldichlorosilane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 651 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyldichlorosilane 2681 75785 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 9 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2398 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethyldichlorosilane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 652 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; laboratory chemical (HSDB) Value 1 5 days 2.24 0.019 1,120 42 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Dimethyltin dichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 653 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dimethyltin dichloride 9560 753731 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Supplemental LD50 Value 73.9 14 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg mg/kg Date 1973 1986 Critical Effect Details of toxic effects not reported other than lethal dose value Neurological damamge to the brain Prevalence Magnitude 6 Incomplete data for scoring HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data rodent-rat; TRIPA7 Tin Research Institute, Publication. (Middlesex, UK) 1934-76. For publisher nformation, see IRIPDP. Volume(issue)/page/year -,1,1973 Aldridgeetal, 1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dimethyltin dichloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 654 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n plastics, food packaging, plastics, pesticides and pa nts (organotins) Value -1.06 20,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Dinitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 655 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dinitrotoluene 28581 25321146 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.025 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1977 Critical Effect Weakness, ataxia, tremors, and neurotoxicity Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other esterases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Prevalence Magnitude „,, „ , „ 2 4 NL' L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26 week rat study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 42(1 0) , 1 7, 1 977 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10J RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.005 0.68 B2 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 19990 Liver, mammary gland EPAHA Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 14 0.05 Y/N Y/N W/L W/L teratogen list EPA, RAISHE UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dinitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 656 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 13 6,802 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; plasticizer (HSDB) Value 38 days 372 2.18 3.96E-07 270 21 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Diphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 657 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diphenylamine 5436 122394 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 0.025 0.025 0.08 2.5 0.833 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Alterations in clinical chemistry parameters. Increased absolute & relative kidney, liver & spleen weights Decreased body weight gain, increased liver and kidney weights Gastrointestinal - alteration in gastric secretion, Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Kidney, Ureter, Bladder - proteinuria Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 88 ' HRL Ratio(s) No water data Notes Reference Dose Reference Dose, Thomas et al., 1967, Basis NOEL=2.5 mg/kg-d, dog, UF=100 Reference Dose Reference Dose, Thomas et al., 1967, NOEL/LEL, dog, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30 day rat study Supplemental Data guinea pig study; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year -,C1 12,1 991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 210 Y/N Y/N W/L W/L teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Diphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 658 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 97 414,131 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 3 15 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide/herbicide; polymer stab lizer; rubber additve; topical veterinary agent (HSDB) Value 1,887 3.5 3.40E-06 53 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Dipropylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 659 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dipropylamine 6158 142847 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1970 Critical Effect Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Behavioral - changes in motor activity (specific assay), Behavioral - muscle weakness Prevalence Magnitude Kll 0 6 7 NL" HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 35(4),103,1970, 26 week rat and rabbit study Supplemental Data rat study; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informat on. Volume(issue)/page/year OTS0544865 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 11.7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dipropylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 660 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 190 1.67 35,100 sr Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Dipropylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 661 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dipropylene glycol 28536 25265718 Attribute Scores 3-model Categorical Prediction Potency Severity 2 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6,200 14.8 14,850 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mL/kg mg/kg mg/kg Date Critical Effect Kidney lesions Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 7 NU HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, SIDS Summary Lowest Observed Adverse Effect Level Supplemental Data Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 11 (1980) 936 rodent-rat; 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, nc., 1969 Volume(issue)/page/year -, 731, 1969 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 43,400 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dipropylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 662 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; antifreeze; in PPCPs; medication (HSDB) Value 1 0.64 5.60E-09 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Diquat CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 663 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Diquat 13896 2764729 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 0.002 30 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Lens opacities cataracts decreased organ weights epidymusadenals Behavioral - somnolence (general depressed activity), Lungs, Thorax, or Respiration - dyspnea, Nutritional and Gross Metabolic - we ght loss or decreased weight gain Prevalence Magnitude 10 5 HRL Ratio(s) NC HRL/CAL DHS 90% : 0.3 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake; as diquat ion Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year 27,51,1970 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW MAC WHOWQ Y 35 0.07 10 Y/N Y/N W/L W/L mg/L Mg/L teratogen list UMD Drinking Water Equivalent Level Provisional Guideline value 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Diquat CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 664 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS # Sam pies Amount Released 266,858 n PWSs/Sites/Sa mples 4,867 OPP Estimated Environmental Concentration HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr #with Detects 9 % Samples with detects Number of States 28 % PWSs/Sites/Sam pies with detects 0.18 Minimum value of Detects Units States States States Minimum value of Detects 0.08 Maximum value of Detects Year 1997 Maximum value of Detects 549 Surface water chronic: 0.4 ug/L Non-cancer: 0.3 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 4.9 90% of Detects 115 Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.006 ug/L Cancer: Herbicide (for diquat dibromide, CASRN 85-00-7) Value 15 2,000 -4.6 1.40E-13 708,000 20 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) For diquat dibromide For diquat dibromide For diquat dibromide For diquat dibromide ------- Disodium iminodiacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 665 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Disodium iminodiacetate 10140 928723 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 8,070 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1972 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 0 , 97 L" L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year -,128,1972, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Disodium iminodiacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 666 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >500M-1 B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial Chemical (EPA/SRS) Value 1 5 days 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Dodecylbenzenesulfonic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 667 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dodecylbenzenesulfonic acid 29930 27176870 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 650 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 85 L' L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger PI. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- VoIume(issueXpage/year 32,245,1974, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Dodecylbenzenesulfonic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 668 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Laboratory chem cal; fungicide stabilizer; in electron cs cleaners (HSDB) Value 1 5 days 4.78 6.27E-08 0.703 ir Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Dodine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 669 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Dodine 13332 2439103 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.004 0.004 0.1 1.25 48 176 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2000 1961 Critical Effect Body weight loss Thyroid Behavioral - food intake (animal), Nutrtional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, 0 10 5 NL: HRL Ratio(s) No water data Notes Reference Dose, American Cyanamid, 1958 Reference Dose, American Cyanamid, 1958, Bass NOEL = 1.25 mg/kg-d, dog, UF=300 Reference Dose Reference Dose; American Cyanamid, 1958, UF=300, dog Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2 year rat study; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 3,127,1961 Supplemental Data rodent-guinea pig; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year-, 64,1 982 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Dodine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 670 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 151,538 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 28 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fungicide (HSDB) Value 15 days 15,500 1.32 6.02E-19 630 31 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Endosulfan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 671 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Endosulfan 5104 115297 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.006 0.006 0.006 0.002 0.006 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 2000 Critical Effect Reduced body weight gain, enlarged kidneys, increased incidences of marked progressive glomerulonephrosis, & blood vessel aneurysms red. body weight gain, glomerular nephrosis red body weight, increased marked progressive glomrulonephrosis hepatic; liver Prevalence Magnitude , „ 10 7 L' HRL Ratio(s) NC HRL/SW Chronic EEC: 28 Notes Reference Dose Reference Dose; Basis NOAEL = 0.7 female and 0.6 male mg/kg-d, Hoechst, 1989a; UF=100 Reference Dose Reference Dose, Hoechst Celanese Corp. 1989, NOAEL/LOAEL, rat, UF=100 Minimal Risk Level, Hoechst, 1989c, Basis NOAEL = 0.18 mg/kg-d, dog, UF=100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 42 Y/N Y/N W/L W/L teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Endosulfan CCL 3 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW August 2009 Page 672 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 1,601,195 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 44 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 1 .5 ug/L Non-cancer: 28 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Ground water chronic: 0.01 2 ug/L Cancer: nsecticide (HSDB) Value 22,000 3.83 6.51 E-05 0.45 5 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- EPIC CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 673 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): EPTC 9581 759944 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 0.025 2.5 112 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1971 Critical Effect Degenerative cardiomyopathy Degenerative cardiomyopathy Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose, PPG Industries, 1986a, Basis NOEL = 2.5 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose, PPG Industries, 1986, NOEL/LEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data mammal- cat; HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(ssue)/page/year 36(1-3), 196, 1971 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 175 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- EPIC CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 674 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,621 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP PPMP CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 # Sam pies Amount Released 8,791,984 12 1,204 n PWSs/Sites/Sa mples 115 12 2,243 406 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 5.7 % Samples with detects Number of States 42 3 3 % PWSs/Sites/Sam pies with detects 5.3 0 Not Detected Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 40 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.03 Not Detected 0.01 Median value of Detects 0.086 90% of Detects 1.5 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L Cancer: Notes Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001(GC/MS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 38 days 258 3.21 1.59E-05 375 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Esfenvalerate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 675 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Esfenvalerate 42403 66230044 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 325 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Maternal toxicity - abnormal gait and mobility Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 5 HRL Ratio(s) NC HRL/SW Chronic EEC: 26.4 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data rodent-rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year -,C287,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Esfenvalerate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 676 of 1124 OCCURRENCE DATA # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 228,885 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 47 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 5.3 ug/L Non-cancer: 26.4 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Ground water chronic: 0.009 ug/L Cancer: nsecticide; medication (HSDB) Value 16. 3 days 100,000-398,000 <1 2 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DFA Notes DFA = Degrades slow with acclimation (HSDB) ------- Estragole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 677 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Estragole 6041 140670 Attribute Scores 3-model Categorical Prediction Potency Severity 2 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 1,230 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect decreased body weight, increased liver weight increased liver enzymes, hematoloficla effects Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, 5 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data, RfD eq, Smith et al 2002, Adbo et al abstract No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data rodent-rat; FCTXAV Food and Cosmetics Toxicoogy. (London, UK) V. 1-19, 1963-81. For publisher nformation, see FCTOD7. Volume(issue)/page/year 14,603,1976 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70,000 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Estragole CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 678 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flavoring agent; n PPCPs (HSDB) Value 38 days 3.47 178 12 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Ethanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 679 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethanol 2462 64175 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1.43 100 3,450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1976 Critical Effect Behavioral - changes in motor activity (specific assay), Behavioral - ataxia, Behavioral - antipsychotic Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 5 HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wllkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 197,488,1976; human study Supplemental Data; Maximum Recommended Da ly Dose (MRDD) Rodent-mouse; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 32(3), 31, 1967 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3.34 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ethanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 680 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released n PWSs/Sites/Sa mples 2 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide; beverage/food additive; medication; solvent (HSDB); gasoline additive Value 1 -0.31 5.00E-06 1,000,000 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Ethephon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 681 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethephon 25550 16672870 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.018 0.005 0.005 0.05 1,250 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1983 Critical Effect Diarrhea, urinary & bowel movements urgency, stomach cramps Plasma cholinesterase inhibition blood Brain and Coverings - recordings from specific areas of CNS, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase, Related to Chronic Data - death Prevalence Magnitude 10 8 HRL Ratio(s) NCHRL/SW Chronic EEC: 18.8 Notes Reference Dose Reference Dose, Union Carbide, 1977a, Basis LEL, human, UF=100 Reference Dose Reference Dose; Union Carbide, 1977, Basis LEL, human, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 8 week rat study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 48(8), 79,1 983 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 126 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethephon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 682 of 1124 OCCURRENCE DATA # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 5,407,986 OPP Estimated Environmental Concentration HRL Ratios (HRL/SW Chronic EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 32 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 6.7 ug/L Non-cancer: 18.8 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Ground water chronic: 0.67 ug/L Cancer: Plant growth regulator (HSDB) Value 3.57 0.05 5.70E-12 1,000,000 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Ethion CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 683 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Ethion 7949 563122 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 0.0005 0.0005 0.0004 0.002 0.5 13 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 2000 1990 Critical Effect Plasma, RBC & brain ChE inhibition Decreased body weight Brain acetylcholinesterase inhibition Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - true cholinesterase Details of toxic effects not reported other than lethal dose value Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3.5 Y/N Y/N W/L W/L Prevalence Magnitude , „ 66 L HRL Ratio(s) NC HRL/SWC EEC: 0.53 Notes Reference Dose; Basis = NOAEL 0.05 mg/kg-d; UF = 100. Reference Dose; Basis = NOEL 0.05 mg/kg-d Reference Dose Reference Dose Minimal Risk Level; Basis = NOAEL 0.06 mg/kg-d Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year 8,173,1988 Supplemental Data PHJOAV Pharmaceutical Journa . (Pharmaceutcal Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933- Volume(issue)/page/year 185,361, 1960 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethion CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 684 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP ambient water PPMP finished water Amount Released 504,535 n PWSs/Sites/Sa mples OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Units Ibsfyr Ibs/yr Ibs/yr #with Detects 0 0 Number of States 2 % PWSs/Sites/Sam pies with detects 0 0 Units States States States Minimum value of Detects Year 1997 Maximum value of Detects Not Detected Not Detected Surface water chronic: 6.6 ug/L Non-cancer: 0.53 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Not Detected Not Detected Units ug/L ug/L Notes Pesticide Pilot Montoring Program (USGS/EPA) Ground water chronic: 0 ug/L Cancer: nsecticide (HSDB) Value 13,200 5.07 9.56E-07 2 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- Ethyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 685 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethyl acetate 6103 141786 Attribute Scores 3-model Categorical Prediction Potency Severity 3 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.9 0.9 25 900 4,100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1986 Critical Effect Mortality & body weight loss mortality and weight loss Behavioral - somnolence (general depressed activity), Behavioral - changes in motor activity (specific assay), Behavioral - coma Prevalence Magnitude , 0 8 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose, U.S. EPA, 1986, Basis NOEL=900 mg/kg-d, rat, UF=1,000 Reference Dose Reference Dose; UF = 1,000; USEPA1986; rat study Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Maximum Recommended Da ly Dose (MRDD) No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data mouse study; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnay Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 6,300 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 686 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; food additive; solvent; medication (HSDB) Value 6.13 0.73 0.000134 80,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Ethyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 687 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethyl acrylate 6050 140885 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 71.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Gastrointestinal - other changes Prevalence Magnitude , 9 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13 week rat study; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0540988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.048 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol. 39, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 167 0.729 Y/N Y/N W/L W/L RAISHE; IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 688 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 249 152,024 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 24 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer additive; former food and PPCP additive (HSDB) Value 11.9 1.32 0.00034 15,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- Ethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 689 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethylamine 2620 75047 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 71.4 400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Gastrointestinal - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 6 8 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0540988 Supplemental Data Lewin, F.J. Saxs, Dangerous Properties of Industiral Materials. 9th ed. Volumes 1-3. New York, NY:Van Norstrand Reinhold, 1996., pi 1517, LD50, rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 690 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL/No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 20 -0.13 1,000,000 48 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (BIODEG) ------- Ethylene glycol monobutyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 691 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethylene glyco monobutyl ether 4970 111762 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 0.5 0.07 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1998 Critical Effect Changes in blood mean corpuscular volume (MCV) changes in mean corpuscular volume Prevalence Magnitude ,,, „ 8 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; NT, 1993, BMD, rat, UF=10 Refernce Dose Reference Dose.NTP, 1993, BMD, mouse, rat, UF=10 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylene glycol monobutyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 692 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n hydraulic fluids; industrial solvent; in PPCPs (HSDB) Value 1 0.83 1.60E-06 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Ethylenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 693 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethylenediamine 4594 107153 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.09 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect iverand kidney toxicity Prevalence Magnitude , „ 87 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Hermanskyet al 1999; Basis NOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 630 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 694 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; ndustrial solvent; in prep of dyes, synthetic waxes, resins, insecticides; veterinary medicine (HSDB) Value 24.7 -2.04 1.73E-09 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Ethylenediaminetetraacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 695 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ethylenediaminetetraacetic acid 2393 60004 Attribute Scores 3-model Categorical Prediction Potency Severity 3 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 250 30 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1966 1991 Critical Effect NOAEL without a LOAEL Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 67 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, Oser et al. 1 966 Lowest Observed Adverse Effect Level Supplemental Data FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year 29,845,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,750 Y/N Y/N W/L W/L Teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ethylenediaminetetraacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 696 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; antioxidant; chelating agent; in PPCPs; veterinary medicine (HSDB) Value 98 -3.86 7.70E-16 1,000 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Fenbutatin oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 697 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Fenbutatin oxide 22779 13356086 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.017 0.03 15 1,450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1991 Critical Effect Decreased pup body weight gain Blood - changes in leukocyte (WBC) count Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 95 L' HRL Ratio(s) No water data Notes Reference Dose; May 31 2002 certified letter to the registrant Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 2,1219,2001 Supplemental Data rodent, mouse; PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR47QG, UK) V.1- 1968- Vo ume(issue)/page/year 9,364,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 119 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fenbutatin oxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 698 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 265,275 0 1,158 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 23 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Acaricide (HSDB) Value 5.2 2.00E-09 0.0127 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Ferbam CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 699 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ferbam 24121 14484641 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.015 0.003 25 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1956 Critical Effect Developmental Neurotoxicity Behavioral - convulsions or effect on seizure threshold, Related to Chronic Data - death Prevalence Magnitude , „ , 9 6 L"L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose, OPP RED Fact Sheet RfD for Thiram Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake, Group ADI for Ferbam and Ziram Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year oral study in dog; JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 118,174,1956 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 105 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Ferbam CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 700 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 317,125 0 0 OPP Estimated Environmental Concentration #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 24 0 0 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 0 ug/L Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 0 ug/L HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Cancer: Fungicide (HSDB) Value 300 -1.6 130 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- Fluometuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 701 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Fluometuron 12839 2164172 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0055 0.013 0.01 0.013 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased body weight gain and discoloration in the spleen. No adverse effects. Decreased Potency Score by one nteger Endocrine - changes n spleen weight, Blood - changes in spleen, Nutritional and Gross Metabol c - weight loss or decreased weight gain Prevalence Magnitude , „ , 95 L' L HRL Ratio(s) NC HRL/NAWQA AW 90% : 19.25 CAR HRL/NAWQA AW 90% : 0.97 Notes Reference Dose Reference Dose, NCI, 1980, NOAEL 12.5, rat, UF=1000 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB80-21 7904 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification 0.018 c 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 OPP Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.5 38.5 1.94 Y/N Y/N mg/L M/L M/L EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Reative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Fluometuron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 702 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP PPMP PPMP HRL Ratios (HRL/NAWQA AW 90%) Production CUSIUR Production Data Use Environmental Fate Parameters r,,2, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,600 ^Samples Amount Released 5,313,290 1,736 1,776 n PWSs/Sites/Sa mples 345 130 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 24 19 2.83 % Samples with detects Number of States 15 1 3 % PWSs/Sites/Sam pies with detects 7.7 8.4 0.003 Minimum value of Detects Units States States States Minimum value of Detects 0.0018 Non-cancer: 19.25 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 37.8 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.0105 0.264 0.1 0.22 Median value of Detects 2 90% of Detects 8.34 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 95% of Detects 0.145 0.062 Units for Mag data ug/L ug/L ug/L Cancer: 0.97 Notes Pesticide Data Program (USDA); 2002 Pesticide Pilot Monitoring Program (USGS/EPA) raw water, 9060(HPLC/MS) Pesticide Pilot Monitoring Program (USGS/EPA) finished water, 9060(HPLC/MS) Herbicide (HSDB) Value 363 2.42 1.80E-09 110 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Fluoroacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 703 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Fluoroacetic acid 6203 144490 Attribute Scores 3-model Categorical Prediction Potency Severity 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00002 0.468 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Increased heart weight, decreased testes weight and spermatogenisis - Sodium salt This is essentially the same as sodium fluoroacetate Prevalence Magnitude , „ , 5 5 Li~L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, R. J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1671 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fluoroacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 704 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former rodenticide (HSDB) Value 500 0.03 50 38 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Fomesafen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 705 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Fomesafen 62548 72178020 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Attribute Scores Potency Severity 6 8 Prevalence Magnitude 9 7 Critical Effect 3-model Categorical Prediction L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.19 C mg/L (mg/kg-d)1 (mg/kg-d)-1 (mg/kg-d)-1 1988 adenoma and carcinoma; liver Huntingdon, 1985; mouse study Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.184 Y/N Y/N W/L W/L RAISHE; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fomesafen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 706 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 1,100,341 2,342 42,651 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 24 2 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (HSDB) Value 6-12 months 11,000 2.9 7.54E-13 50 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (HSDB) ------- Fonofos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 707 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Fonofos 10236 944229 Attribute Scores Potency Severity 6 5 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 0.002 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect RBC ChE inhibition, cholinergic symptoms (tremors, acrimation, salivation), increased liver weight RBC ChE inhibition, cholinergic symptoms (tremors, acrimation, salivation), increased liver weight 3-model Categorical Prediction NL HRL Ratio(s) NC HRL/NAWQA 90% : 31 1 Notes Reference Dose Reference Dose, Stauffer Chemical Co, 1969, NOEL 0.2, dog, UF=100 Reference Dose Reference Dose, Stauffer Chem cal Co, 1969, NOEL/LEL, dog, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.07 14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Fonofos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 708 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,116 # Sam pies Amount Released 417,372 n PWSs/Sites/Sa mples 283 669 3 95 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 1.3 1.34 % Samples with detects Number of States 33 /O PWSs/Sites/Sam pies with detects 0.1 0.001 Minimum value of Detects Units States States States Minimum value of Detects 0.0075 0.04 Non-cancer: 311 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.2 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.0075 0.007 Median value of Detects 0.045 90% of Detects 0.21 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2002(GC/MS) Cancer: Restricted use insecticide; fumigant (HSDB) Value 38 days 864 3.94 6.97E-06 15.7 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Formetanate hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 709 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Formetanate hydrochloride 27710 23422539 Attribute Scores 3-model Categorical Prediction Potency Severity 6 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00065 18 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1979 Critical Effect Cholinesterase inhibition in the pup brain Prevalence Magnitude , „ , 10 5 L' L HRL Ratio(s) NC HRL/SWC EEC: 56.9 Notes Reference Dose; IRED Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data mouse; Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, 1979., p. 284 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4.55 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Formetanate hydrochloride CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 710 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 134,527 # PWSs/Sites sampled OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 27 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Surface water chronic: 0.08 ug/L Non-cancer: 56.9 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Notes Ground water chronic: Cancer: nsecticide (HSDB) Value 3.2-212 2.30E-19 >500,000 42 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Formic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 711 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Formic acid 2463 64186 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2 360 700 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1921 1979 Critical Effect Decreased growth Behavioral - food intake (animal), Nutrtional and Gross Metabolic - weight loss or decreased weight gain Behavioral - somnolence (general depressed activity), Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude 10 10 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA, NOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 9-week oral study in rat; JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 16,463,1921 Supplemental Data rodent, mouse; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 23(12), 49, 1979 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14,000 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Formic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 712 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 240,191 10,144,003 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 22 38 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; chemical intermediate; pesticide; in pa nt strippers (HSDB) Value 1 -0.54 1.67E-07 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Furan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 713 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Furan 4814 110009 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.001 21.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1993 Critical Effect Minimal to mild liver lesions. Increased relative liver weight iver Liver - other changes, Liver - changes n liver weight, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , „ 68 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose, NTP, 1982, NOAEL 2, mouse, UF=1000 Reference Dose Reference Dose, NTP, 1982, NOAEL/LOAEL, mouse, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in mouse; NTPTR National Toxicology Program Techn cal Report Series. (Research Tr angle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-402,1993 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7 Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Furan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 714 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 89.7 1.34 0.00541 10,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (HSDB) ------- Furfural CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 715 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Furfural 3927 98011 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.003 53.6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1990 Critical Effect Mild hepatocellular vacuolization iver Liver - changes in liver weight Prevalence Magnitude 6 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose, NTP, 1981a, LOAEL 11, rat. UF=3000 Reference Dose Reference Dose, NTP, 1981, LOAEL, rat. UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in mouse; NTPTR National Toxicology Program Techn cal Report Series. (Research Tr angle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-382,1990 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Furfural CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 716 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; flavoring; chemical intermediate (HSDB) Value 17.7 0.41 3.38E-06 77,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Furfuryl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 717 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Furfuryl alcohol 3826 96297 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4 75 930 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Hematological effects, increase in spleen relative and absolute weights. Endocrine - changes in spleen weight, Blood - pigmented or nucleated red blood cells, Blood - changes in erythrocyte (RBC) count Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „,, 0 6 7 NL: HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientif c & Technical Information. Volume(issue)/page/year OTS0524679; 13 week rat study Supplemental Data Rodent-rat; TSCAT Office of Tox c Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year OTS 513319 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 28 Y/N Y/N ug/L ug/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Furfuryl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 718 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Antioxidant (ChemlDPIus); Industr Value 0.63 1.04E-05 100,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes al chemical (EPA/SRS) Degradation Code BS Notes BS = Biodegrades s ow (BIODEG) ------- gam ma-Butyrolactone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 719 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): gam m a-Butyrolactone 3838 96480 Attribute Scores Potency Severity 4 5 Prevalence Magnitude 7 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 175 262 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased respiration and activity in mice. Hyperplasia of the adrenal medula (males) decreased body weight gain (females). Cancer equivocal evidence male mice. No evidence male or fema e rats and female mice 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP Report 406 Lowest Observed Adverse Effect Level Supplemental Data; NTP Report 406 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1999 Vol. 11, Suppl. 7, Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,225 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- gam ma-Butyrolactone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 720 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent in PPCPs (HSDB) Value 1 5 days 7.1 -0.64 5.30E-08 1,000,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Glutaraldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 721 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Glutaraldehyde 4927 111308 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Liver - fatty liver degeneration, Nutritional and Gross Metabolic - weight loss or decreased weight gain, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Prevalence Magnitude 6 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (VTO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue);pagefyear52(3),77,1987 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.7 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Glutaraldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 722 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; embalm ng fluid; chemical intermediate (HSDB) Value -0.18 1.10E-07 1,000,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Glycerine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 723 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Glycerine 2289 56815 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 16 850 4,090 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 1977 Critical Effect Skin and Appendages - tumors, Tumorigenic - facilitates action of known carcinogen Ql tract: hyperaemia, petechial haemorrhage or erosions (DR) Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 8 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 25-week study in mouse. CALEDQ Cancer Letters (Shannon, reland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year 1 55,61 ,2000 Supplemental Data, SIDS rodent, mouse; FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year (6), 56,1977 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,217 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Glycerine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 724 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; in PPCPs; food additive; in res ns (HSDB) Value -1.76 1.75E+11 1,220,000 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Glycidol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 725 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Glycidol 7880 556525 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 19 150 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Effects on sperm count and testicular histopathology Brain and Coverings - demyelination, Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) testicular atrophy, reduced survival, Related to Chronic Data - death Clear evidence of carcinogenicity in mice and rats 2 species and 2-sexes Prevalence Magnitude 1 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; NTP Lowest Observed Adverse Effect Level Supplimental Data, NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-374,1990 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 133 Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Glycidol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 726 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; stabilizer (HSDB) Value 1 5 days -0.95 5.84E-09 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Glyoxal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 727 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Glyoxal 4600 107222 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.2 297 200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect decreased body weight gain Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - weight loss or decreased weight gain, Biochemica - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases Behavioral - muscle weakness Prevalence Magnitude ,,, „ 6 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; IPCSCICAD2004 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher nformation, see TOSCF2 Volume(issue)/page/year 16,763,1991 Supplemental Data rodent, rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informaton. Volume(issue)/page/year OTS0533618 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,400 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Glyoxal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 728 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n textiles; chemical intermediate (HSDB) Value 1 5 days 1 -1.66 3.33E-09 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- HCFC-133a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 729 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): HCFC-133a 2690 75887 Attribute Scores Potency Severity Prevalence Magnitude 3 6 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol. 41,Suppl7, Vol71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- HCFC-133a CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 730 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 23 56,253 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Refrigerant; chemical intermediate (HSDB); gas Value 38 30 0.27 9,200 47 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Heptane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 731 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Heptane 6156 142825 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2.86 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver -changes in liver weight Prevalence Magnitude 8 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issueXpage;yearOTS0571116 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 6.67 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Heptane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 732 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Gasoline standard; anesthetic, solvent, in organic synthesis (HSDB) Value 275 4.66 2.00E+00 3.4 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Hexachlorobutadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 733 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexachlorobutadiene 3263 87683 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0002 0.0002 0.0002 0.00034 2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 1965 Critical Effect ncrease in urinary coproporphyrin excretion & increase in renal tubular epithelial hyperplasiafproliferation regeneration kidney Liver - other changes, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Immunological ncluding Allergic - increase in cellular mmune response Prevalence Magnitude , „ 45 L' HRL Ratio(s) NC HRL/NCOD R1 90%: 0.28 Notes Reference Dose Reference Dose Reference Dose Reference Dose, USEPA, 1993; Basis LOAEL, mouse, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake, .Yangetal., 1989, NTP1991, BMLD(50), mouse, UF=100 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-week oral study in guinea pig; GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 9(1 11,50,1965 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.05 0.078 C 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1.4 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexachlorobutadiene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 734 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,284 22,736 43 41 0.35 0.18 0.05 0.1 10 1.5 0.25 0.3 5 0.8 10 1.5 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,310 # Sam pies Amount Released 5 742 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 3 % PWSs/Sites with detects 0.14 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.28 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; chlorine gas scavenger; solvent; hydraulic fluids (HSDB) Value 994 4.78 0.0103 3.2 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Hexachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 735 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexachloroethane 2514 67721 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.001 0.001 0.01 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Renal lesions, including renal atrophy, degeneration, hypertrophy, & dilation kidney, atrophy and degeneration of renal tubules Prevalence Magnitude ,,, 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Referenc Dose, Gorzinski et al., 1985, NOAEL 1 mg/kg-d, rat, UF=1000 Reference Dose Reference Dose.Gorzinski et al., 1985, NOAEL/LOAEL, rat, UF=1000 Minimal Risk Level; Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.3 0.014 0.039 C 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7 3 Y/N Y/N W/L W/L CACART; EPA; RAISHE; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 736 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,618 # Sam pies Amount Released 5 1,015 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 8 % PWSs/Sites with detects 0.05 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M >10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame inhibitor/retardant; polymer additive; in organic synthesis (HSDB) Value 10,600 5.2 1.00E-05 0.25 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Hexahydro-1,3,5-tris(2-hydroxye CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 737 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine 16177 4719044 Attribute Scores 3-model Categorical Prediction Potency Severity 8 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1.99 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value - Dermal sensitization Prevalence Magnitude 6 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year #3824309 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexahydro-1,3,5-tris(2-hydroxye CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 738 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Bacteriocide (ChemlDPIus) Value 38 days 47 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Hexahydroazepine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 739 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexahydroazepine 4944 111499 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 90 20.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Some discomfort on dosing Behavioral - food intake (animal), Lungs, Thorax, or Respiration - pulmonary emboli, Liver - other changes Prevalence Magnitude ,,, _ 5 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; OPPT Summary, NOAEL Lowest Observed Adverse Effect Level Supplemental Data Rodent, rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Informat on. Volume(issue)/page/year OTS0534842 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 630 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexahydroazepine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 740 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 170 6.10E-06 31,900 36 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Hexamethylene-1,6-diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 741 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexamethylene-1 ,6-diisocyanate 9801 822060 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 350 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 7 3 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Supplemental Data LD50.TAKHAA Takeda Kenkyusho Ho. Journa of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year 39,202,1980, rodent, mouse Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexamethylene-1,6-diisocyanate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 742 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer additive; adhesive; chemcal intermediate (HSDB) Value 5,864 3.2 4.80E-05 117 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Hexamethylenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 743 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexamethylenediamine 5553 124094 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 150 750 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1977 Critical Effect 2-generation study; reduced litter size, reduced maternal and pup weights Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, Short el a , 1991 , NOAEL Lowest Observed Adverse Effect Level Supplemental Data rodent, rat; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 42,417,1977 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,050 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Hexamethylenediamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 744 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 286 3.20E-09 2,460,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Hexamethylenetetramine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 745 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hexamethylenetetramine 4151 100970 Attribute Scores 3-model Categorical Prediction Potency Severity 3 2 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,234 569 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1970 Critical Effect Yellow discoloration of fur Behavioral - excitement, Behavioral - muscle contraction or spasticity Prevalence Magnitude ,,, „ 7 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data, Porta, 1965, LOAEL Rodent, mouse; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 35(3), 115,1970 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,879 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hexamethylenetetramine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 746 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Adhesives/coatings; medications; catalyst (HSDB) Value 553 1.60E-09 667,000 98 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- HMX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 747 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): HMX 13804 2691410 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 0.05 0.05 0.05 0.994 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1988 1997 1975 Critical Effect Hepatic lesions Hepatic lesions Hepatic Brain and Coverings - other degeneratve changes, Behavioral - alteration of classical conditioning Prevalence Magnitude ,,, „ 3 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S. DOD, 1985a; Basis NOAEL 50 mg/kg-d, rat, UF=1000 Reference Dose Reference Dose; U.S. DOD, 1985a; Basis NOAEL/LOAEL 50 mg/kg-d, rat, UF=1000 Minimal Risk Level; Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 22-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/vear 40(1 1 ), 1 7, 1 975 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1989 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2 350 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- HMX CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 748 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >500K-1 M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Explosive (HSDB) Value 38 days 1,853 0.82 8.66E-10 2,556 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Hydrochloric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 749 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hydrochloric acid 19106 7647010 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg mg/kg mg/kg Date 1996 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 10 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1835, rabbit Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L Teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Hydrochloric acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 750 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in food processing (HSDB) Value 14.3 0.54 0.0245 42,400 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Hydrocinnamic acid, 3,5-di-tert CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 751 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hydrocinnamic acid, 3,5-di-tert-butyl-4-hydroxy-, methyl ester 17833 6386385 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - food intake (animal), Liver - other changes, Blood -changes in leukocyte (WBC) count Prevalence Magnitude 7 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 221 61) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0539881; 90-day rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,400 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydrocinnamic acid, 3,5-di-tert CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 752 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate; in etching (HSDB - uses for 1,2-, 1,3- and 1,4-diethylbenzene) Value 60 days 6 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- Hydrogen sulfide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 753 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hydrogen sulfide 19345 7783064 Attribute Scores Potency Severity 6 3 Prevalence Magnitude 10 ncomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 0.03 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Gastrointestinal disturbance. RfD withdrawn in IRIS 2003. Questionable study. 3-model Categorical Prediction HRL Ratio(s) No water data Notes Reference Dose Reference Dose, Watterau etal., 1964, NOAEL, pig, UF=1000 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydrogen sulfide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 754 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; disinfectant (HSDB) Value 14.3 -1.38 0.00869 3,740 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Hydroquinone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 755 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hydroquinone 5502 123319 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 35.7 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Hematological effects Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - multiple enzyme effects Prevalence Magnitude 8 8 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, Carlson and Brewer, NOAEL, human, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 6-week oral study in rat; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher nformation, see TOSCF2 Volume(issue)/page/year 23,397,1994 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.056 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 280 0.625 Y/N Y/N W/L W/L RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydroquinone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 756 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 11,265 574,933 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 14 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Photographic chemical; antioxidant; chemical intermediate; medication (HSDB) Value 434 0.59 4.72E-11 72,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Hydroxyethyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 757 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Hydroxyethyl methacrylate 9951 868779 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 2.5 3,275 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1989 Critical Effect Decreased relative organ weight Liver - other changes, Blood - changes in spleen Behavioral - coma Prevalence Magnitude 6 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 35-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 52(11), 81, 1987 Supplemental Data Rodent-mouse; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 54(9), 75,1989 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Hydroxyethyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 758 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10M-50M >10M-50M Polymer intermec Value 43 0.47 4.60E-09 1,000,000 39 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Iron pentacarbonyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 759 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): ron pentacarbonyl 22932 13463406 Attribute Scores 3-model Categorical Prediction Potency Severity 7 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 12 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Nanomaterial - no information provided Prevalence Magnitude , „ , 2 6 Li L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1946, rabbit Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Iron pentacarbonyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 760 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 43,51 r # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Gasoline additive; chemical intermediate (HSDB) Value 3 50-100 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Isobutanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 761 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): sobutanol 2836 78831 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 3 1,022 74.1 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1984 Critical Effect Hypoactivity & ataxia Behavioral - somnolence (general depressed activity), Nutritional and Gross Metabolic - changes in potassium, Related to Chronic Data - death Details of toxic effects not reported other than lethal dose value Prevalence Magnitude „, „ , „ 8 7 NL' L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose, U.S.EPA, 1986, NOEL 316 mgrtsg-d, rat, UF=1000 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0531 063 Supplemental Data VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1 994. Volume(issue)/page/year -, 1 02, 1 984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,100 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Isobutanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 762 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; solvent; flavoring (HSDB) Value 2.05 0.76 9.79E-06 85,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Isobutene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 763 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): sobutene 5093 115117 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 10 8 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Some evidence of carcinogenicity in male rats (NTP) Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isobutene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 764 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units Cancer: Notes Chemical intermed ate; octane enhancer; in polymers (HSDB) Value 15 450 2.34 0.218 263 88 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Isobutyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 765 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): sobutyl acetate 4829 110190 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4,763 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mgflsg Date 1972 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 75 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rodent-rabbit; IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.1 8-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year 41,31, 1972 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isobutyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 766 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; so vent (HSDB) Value 200 1.78 0.00045 6,300 sr Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Isobutyronitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 767 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Isobutyronitrile 2835 78820 Attribute Scores 3-model Categorical Prediction Potency Severity 7 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 55 L' L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1960, mouse Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isobutyronitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 768 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; gasoline additive (HSDB) Value 42 0.46 5.39E-05 43 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Isooctyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 769 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): sooctyl acrylate 30980 29590429 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Behavioral -somnoence (general depressed activity), Behavioral - ataxia, Gastrointestina - hypermotility, diarrhea Prevalence Magnitude 8 5 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC20005) V.1- 1975/76- Volume(issue)/page/year34,297,1991, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isooctyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 770 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemical (EPA/SRS) Value 1 5 days 16 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Isophthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 771 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Isophthalic acid 5410 121915 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 250 10,400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Kidney effects - crystalluria, mild hydronephrosis, pelvic calcification Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 0 , „ 8 7 NL' L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, Sid assessment Lowest Observed Adverse Effect Level Supplemental Data rodent-rat; 85JCAE "Prehled Prumyslove Toxikoogie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,317,1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,750 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isophthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 772 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical and polymer intermediate (HSDB) Value 1 5 days 72 1.66 2.90E-13 130 27 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Isoprene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 773 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Isoprene 2833 78795 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2.49 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgftg-d mg/kg-d mg/kg mg/kg mg/kg Date 1959 Critical Effect Behavioral - alteration of classical conditioning Prevalence Magnitude , „ , 88 L' L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (WOMezhdunarodnayaKniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year24(6),8,1959 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 5.81 Y/N Y/N M8/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isoprene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 774 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n synthesis of rubber and natural products (HSDB) Value 1 5 days 490 2.42 0.077 642 89 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Isopropanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 775 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Isopropanol 2509 67630 Attribute Scores 3-model Categorical Prediction Potency Severity 3 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI BMDL CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 407 18 4.5 3,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1993-1994 Critical Effect Decrease in male mating index.(another study- Gentry, et al. give 500mg/kg NOAEL and also add decreased fetal body weight). Endocrine - effect on menstrual cycle; Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Behavioral - altered sleep time (including change in righting reflex), Behavioral - somnolence (general depressed activity); AND Behavioral - general anesthetic Prevalence Magnitude 10 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data (Benchmark Dose), BMDL10, Shipp et al. 1996 No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 122-day oral study in rat; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia Supplemental Data mouse; Clayton, G. D., F. E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994, p. 2630 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 11 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 43(1), 8,1 978; AND VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Ga ogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/vear -, 97,1 984 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 2,849 Y/N Y/N W/L W/L teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Isopropanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 776 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; food additive; solvent (HSDB) Value 1.06 0.05 8.10E-06 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Isopropyl formate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 777 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Isopropyl formate 8937 625558 Attribute Scores 3-model Categorical Prediction Potency Severity 8 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1969 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 5 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 28ZEAL "Pesticide Index," Frear, E.H., ed.( State College, PA, College Science Pub., 1969 Volume(issue)/page/year 4,256,1969, rodent-guinea pig Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isopropyl formate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 778 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fumigant; chemica intermediate (HSDB) Value 1 5 days 18 0.000775 20,700 49 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Isopropylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 779 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): sopropylamine 2645 75310 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 111 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - somno ence (general depressed activity), Lungs, Thorax, or Respiration -dyspnea, Gastrointestinal - other changes Prevalence Magnitude , „ , 88 L' L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/pagefyear OTS054201 1 , rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Isopropylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 780 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate (HSDB) Value 30 0.26 1,000,000 49 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (BIODEG) ------- Kodaflex txib CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 781 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Kodaflex txib 18352 6846500 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Attribute Scores Potency Severity 5 6 Prevalence Magnitude 7 5 Critical Effect Increased liver weight; Increase in grade of change of renal tubular epithe ium and hyaline droplet degeneration. 3-model Categorical Prediction NL"7 - L"7 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Kodaflex txib CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 782 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Plasticizer in food packaging (ChemlDPIus) Value 38 days 12 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Lactofen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 783 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Lactofen 65964 77501634 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.008 0.002 0.002 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Kidney lesions and weight changes to the thyroid and adrenal glands ncr. abs./rel. liver weight; hepatocytomegaly-M ncreased absolute and relative weight; hepatocytomegaly in males Prevalence Magnitude , „ , 10 6 L' L HRL Ratio(s) NC HRL/SWC EEC: 4,667 Notes Reference Dose Reference Dose, PPG Industries, 1985a, LEL 1.5 mg/kg-d, mouse, UF=1000 Reference Dose Reference Dose, PPG Industries, 1985a, LEL, mouse, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 56 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Lactofen CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 784 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP # Sam pies Amount Released 389,388 0 0 n PWSs/Sites/Sa mples 115 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 26 0 0 % PWSs/Sites/Sam pies with detects Minimum value of Detects Units States States States Minimum value of Detects Maximum value of Detects Year 1997 2002 2002 Maximum value of Detects Surface water chronic: 0.012 ug/L Non-cancer: 4,667 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Notes Pesticide Data Program (USDA) 2002 Ground water chronic: Cancer: Herbicide (HSDB) Value 25,400 4.81 5.73E-10 0.1 3 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Lactonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 785 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Lactonitrile 2849 78977 Attribute Scores Potency Severity 5 4 Prevalence Magnitude 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6 31 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver cell enlargement or alteration, Blood- signif decreases in GOT and signif increases in total protein, albumin, and Ca. Swelling of Liver. 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data male' Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 42 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Lactonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 786 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1994 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate (HSDB) Value 9 min 1 -0.94 9.80E-06 1,000,000 45 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- lambda-Cyhalothrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 787 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): lambda-Cyhalothrin 67650 91465086 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 56 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Decreased maternal weight gain during pregnancy; decreased neonatal weight gain during weaning Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 10 6 L"L HRL Ratio(s) NC HRL/SWC EEC: 357 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year 9,203,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- lambda-Cyhalothrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 788 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP # Sam pies Amount Released 321,284 n PWSs/Sites/Sa mples 0 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 43 /o PWSs/Sites/Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 Maximum value of Detects Not Detected Surface water chronic: 0.098 ug/L Non-cancer: 357 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L Notes Pesticide Pilot Monitoring Program (USGS/EPA) 9002(GC/MS) Ground water chronic: 0.01 2 ug/L Cancer: nsecticide (HSDB - data for cyhalothrin, CASRN 68085-85-8) Value 7 1.35E-05 8,530 1 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Lead acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 789 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Lead acetate 11430 1335326 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude , 5 10 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.038 B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 From OEHHA Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.921 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Lead acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 790 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Analytical reagent (HSDB) Value -4 250,000 Units ength of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Linuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 791 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Linuron 6584 330552 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.008 0.002 0.002 4.93 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1975 Critical Effect Decreased RBC count, hematocrit& hemoglobin levels Abnormal blood pigment Abnormal blood pigment Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes Prevalence Magnitude 1 1 NL HRL Ratio(s) NC HRL/NAWQA 90% : 21 5 Notes Reference Dose; du Pont, 1962 Reference Dose Reference Dose; du Pont, 1962; Basis LEL 0.625 mg/kg-d, dog, UF=300 Reference Dose; du Pont, 1962; Basis LEL, dog, UF=300 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 31-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(7), 46,1 975 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 1989 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 56 Y/N Y/N W/L W/L Developmental CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Linuron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 792 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 298 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,142 # Sam pies Amount Released 516,133 0 11 n PWSs/Sites/Sa mples 154 339 # Sites 142 105 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 0 #with Detects 0 1.47 % Samples with detects Number of States 35 0 2 % PWSs/Sites/Sam pies with detects 0.3 0 % PWSs/Sites with detects 0 0.0005 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Minimum value of Detects Not Detected Non-cancer: 215 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 1.4 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Maximum value of Detects Not Detected 0.03 Median value of Detects 0.26 90% of Detects 0.74 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected Median value of Detects Not Detected 99% of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L Cancer: Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA)2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001 (GC/MS) Pesticide Pilot Monitoring Program (USGS/EPA) 9060 (HPLC/MS) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 60 days 350 3.2 6.26E-09 75 12 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Lithium carbonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 793 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Lithium carbonate 7842 554132 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 404 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1998 Critical Effect Brain and Coverings - recordings from specific areas of CNS, Liver - liver function tests impaired, Blood - pigmented or nucleated red blood cells Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthes a, Behavioral - tetany, Cardiac - arrhythmias (including changes in conduction) Prevalence Magnitude 87 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) PotentsiaPno Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999 Supplemental Data VCVN1 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988. Volume(issue)/page/year -, 25,1 998 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 23.3 Y/N Y/N M8/L W/L Developmental CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Lithium carbonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 794 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 5 21 1 ,661 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 14 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Coatings; chemica intermediate; medication (HSDB) Value 13,100 Units length of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Lithium chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 795 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Lithium chloride 18915 7447418 Attribute Scores 3-model Categorical Prediction Potency Severity 8 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.009 526 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1998 Critical Effect Cardiac - pulse rate increase, without fall in BP, Liver - iverfunction tests impaired, Blood - changes in erythrocyte (RBC) count Behavioral - tetany, Lungs, Thorax, or Respiration - respiratory depression, Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude 1 Incomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, ZhivopisnayaSt., 123182, Moscow, Russia, IzdAT 1999 Supplemental Data VCVN1 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988. Volume(issue)/page/year -, 26,1 998 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.021 Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Lithium chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 796 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; salt baths; dessicant; in welding (HSDB) Value 832,000 Units length of time Ukg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Malathion CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 797 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Malathion 5402 121755 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.07 0.02 0.02 0.02 0.02 0.3 0.34 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 2001 Critical Effect RBC ChE inhibition Red blood cell cholinesterase inhibition RDB ChE depression cholinesterase inhibit on Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Prevalence Magnitude 9 3 NL HRL Ratio(s) NC HRL/NAWQA 90%: 5,698 Notes Reference Dose, Moeller and Rider, 1962 Reference Dose, Moeller and Rider, 1962, basis NOEL 0.23 mg/kg-d, human, UF=10 Reference Dose Reference Dose, Moeller and Rider, 1 962, basis NOEL/LEL, human, UF=1 0 Minimal Risk Level, Daly, 1996, basis NOAEL 2 mg/kg-d, rat, UF=100 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 56-day oral study in human; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 1 ,59,2001 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW MAC Y 0.8 490 0.19 Y/N Y/N mg/L W/L W/L mg/L teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Malathion CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 798 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - total Supplemental Water Data POP POP PPMP CAL DHS HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,117 # Sam pies Amount Released 5,809,943 10,288 24,199 n PWSs/Sites/Sa mples 283 669 271 344 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 4.83 % Samples with detects Number of States 42 2 8 /O PWSs/Sites/Sam pies with detects 0 0 0.0015 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Not Detected Non-cancer: 5,698 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 9.58 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected 0.014 Median value of Detects 0.086 90% of Detects 0.39 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected Not Detected 99% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001(GC/MS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Cancer: Insecticide; veter nary medicine (HSDB) Value 11 days 30.5 2.36 4.89E-09 143 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Maleic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 799 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Maleic anhydride 4681 108316 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.1 390 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1982 Critical Effect Renal lesions Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose U.S. EPA, 1982, NOAEL 10mg/kg-d, rat, UF=100 Reference Dose Reference Dose, EPA 1983, NOAEL/LOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rodent, guinea pig; 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year -, 79,1 982 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Maleic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 800 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,185 769,446 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 31 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; petroleum additive (HSDB) Value 0.37 minutes 1 1.62 3.94E-06 4,912 35 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Maleic hydrazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 801 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Maleic hydrazide 5504 123331 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.25 0.5 0.5 0.5 0.3 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1996 Critical Effect Decreased body weight gain Kidney Renal dysfunction Prevalence Magnitude ,,, „ 10 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose, Uniroyal Chemical, 1981, basis LEL 500 mg/kg-d, rat, UF=1000 Reference Dose Reference Dose; Uniroyal Chemical, 1981, basis LEL, rat, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 20 1,750 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Maleic hydrazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 802 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,143,154 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 36 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (HSDB) Value 10.4 -0.84 2.64E-11 4,510 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- Malononitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 803 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Malononitrile 4794 109773 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 5.86 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect hepatic effects Liver - other changes, Kidney, Ureter, Bladder - other changes Prevalence Magnitude 2 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, Lonza 1989, NOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 28-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0526327 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Malononitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 804 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 854,039 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L s ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; petroleum additive (HSDB) Value 15 days 15.3 -0.6 1.27E-08 133,00 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Maneb CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 805 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Maneb 22381 12427382 Attribute Scores 3-model Categorical Prediction Potency Severity 4 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 0.005 0.005 0.03 0.05 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1977 1988 1993 Critical Effect ncreased thyroid weight &follicular cell hypertrophy, decreased T4 increased thyroid we ght increased weight thyroid Prevalence Magnitude , „ 10 8 L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose, Rohm and Haas Co., 1977; Maneb Task Force, 1986, Reference Dose, Rohm and Haas Co., 1977; Maneb Task Force, 1986, NOEL 5mg/kg-d, primate, UF=100 Reference Dose Reference Dose; Maneb Task Force, 1986, NOEL/LEL, monkey, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake, NOAEL, Ulrich, 1986 and 1987 as cited in JMPR, 1984, rat, UF=100 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 350 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Maneb CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 806 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 3,039,930 0 335 OPP Estimated Environmental Concentration HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 43 0 1 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 0 ug/L Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 0 ug/L Cancer: Fungicide (HSDB) Value 10 0.62 5.65E-07 6.2 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- MCPA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 807 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): MCPA 3709 94746 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0044 0.0005 0.0005 3.9 439 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1980 Critical Effect Hepatotoxicity & nephrotoxicity kidney, liver Tumorigenic - carcinogenic by RTECS criteria, Blood - eukemia Details of toxic effects not reported other than lethal dose value Prevalence Magnitude .,, „ 6 5 NL--L- HRL Ratio(s) NC HRL/NAWQA AW 90% : 45.29 Notes Reference Dose Reference Dose, Industry Task Force on MCPA, 1986a, Basis NOEL 0.15 mg/kg-d, dog, UF=300 Reference Dose Reference Dose, Industry Task Force on MCPA, 1986a, Basis NOEL/LEL, dog, UF=300 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 78-week oral study in mouse; TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept, P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year 160,97,1990 Supplemental Data RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1 , Poland) V.1- 1950- Volume(issue)/page/year31, 373,1980 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer WHODWQ Y 0.02 30.8 2 Y/N Y/N mg/L W/L W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- MCPA CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 808 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP CAL DHS HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,548 # Sam pies Amount Released 5,360,932 0 221 n PWSs/Sites/Sa mples 163 285 1 20 44 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 4 0 0.97 % Samples with detects Number of States 31 0 3 % PWSs/Sites/Sam pies with detects 1.4 0.4 0 0.006 Minimum value of Detects Units States States States Minimum value of Detects 0.012 Non-cancer: 45.29 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 18.6 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.012 0.17 Median value of Detects 0.68 90% of Detects 18.6 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 9060(HPLS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalconta minants.aspx Cancer: Herbicide (HSDB) Value 15 days 29.4 3.25 1.33E-09 630 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- m-Cresol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 809 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): m-Cresol 4686 108394 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 0.05 300 1,500 2,007 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased body weights & neurotoxicity Decreased weight and neurotoxicity Brain and Coverings - changes in brain weight, Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight Prevalence Magnitude 8 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose, U.S. EPA, 1986, 1987, NOAEL, rat, UF=1000 Reference Dose Reference Dose, U.S. EPA, 1987, NOAEL/LOAEL, rat, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 28-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB92-1 74242 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification C mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 350 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- m-Cresol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 81 Oof 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 2,547 374,903 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 3 15 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr nsecticide; disinfectant; chemica Value 434 1.96 8.56E-07 22,700 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ntermediate (HSDB) Degradation Code BF/BFA Notes BF = Biodegrades fast/BFA = biodegrades fast with acclimat on (BIODEG) ------- m-Dichlorobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 811 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): m-Dichlorobenzene 7698 541731 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.09 0.03 37 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 Critical Effect Hepatic necrosis, porphyria Endocrine - other changes, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - dehydrogenases Prevalence Magnitude ,,, „ 4 7 NL' HRL Ratio(s) NC HRL/NCOD R1 90%: 70 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level; Int Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year 18,201,1995 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3 630 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- m-Dichlorobenzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 812 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NGOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 20,429 24,119 51 62 0.25 0.26 0.03 0.1 22.4 15 1.1 0.6 9.1 2.8 22 15 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,353 # Sam pies Amount Released 377 1,939 n PWSs/Sites/Sa mples 11,938 29 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 0.67 % Samples with detects Number of States 3 6 /O PWSs/Sites/Sam pies with detects 0.01 0.001 Minimum value of Detects Units States States States Minimum value of Detects 0.64 Non-cancer: 70 Amount Range >500K-1M Units Ibs/yr Ibs/yr Year 1998 2002 0.1 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.64 0.017 Median value of Detects 0.06 90% of Detects 0.1 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.64 90% of Detects 0.64 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Fumigant/insecticide; chemical intermediate (HSDB) Value 38 days 434 3.53 0.00264 125 14 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Melamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 813 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Melamine 4717 108781 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 178 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1983 Critical Effect Kidney, Ureter, Bladder chronic inflamation in females; nephropathy- other changes at both doses - suvival decreased at high dose (males) - Cancer positive for males rats and negative forfemale rats and mice Prevalence Magnitude , „ 8 7 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data, NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue);page/yearNTP-TR-245,1983 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol73 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 415 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Melamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 814 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E> Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in resins; eather tanning (HSDB) Value -1.37 1.80E-14 3,240 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- Mepiquat chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 815 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Mepiquat chloride 27927 24307264 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 0.03 0.03 75 464 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1992 1991 Critical Effect Impaired neurological function; vacuolization of the renal distal tubules; increased hemosiderin functions Sedation Stonodonic spasms, dec food intake & body wt Blood - other changes, Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 9 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose; BASF Wyandotte Chemical 1977a; Basis NOEL 25 mg/kg-d, dog, UF=1000 Reference Dose Reference Dose, BASF WyandotteChemical 1977, NOEL/LEL, dog, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in dog; NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Vo ume(issue)/page/year 17,3269,1992 Supplemental Data FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year-,C241,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 4,200 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Mepiquat chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 816 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 182,576 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 16 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Plant growth regulator (HSDB) Value 15 days 174 -2.82 4.31 E-1 2 500,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Mercaptoacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 817 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Mercaptoacetic acid 2522 68111 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 114 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/Kg Date Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 6 8 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data ZHYGAM Zeitschrift fuer die Qesamte Hygiene und Ihre Qrenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year 20,575,1974 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Mercaptoacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 818 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Chemical intermed ate; electroplat Value 27 0.09 1.90E-08 1,000,000 36 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Year 1998 2002 Maximum value of Detects Year 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units Cancer: Notes ng; plasticizer (HSDB) Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Merphos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 819 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Merphos 6275 150505 Attribute Scores 3-model Categorical Prediction Potency Severity 8 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00003 0.00003 170 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1962 Critical Effect Ataxia, delayed neurotoxicity & weight loss ataxia, delayed neurotoxicity, weight loss Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 1 1 NL' HRL Ratio(s) NC HRL/CAL DHS 90%: 0.05 Notes Reference Dose Reference Dose, Abou-Donia et al., 1980; Basis NOEL 0.1 mgftg-d, hen, UF=3000 Reference Dose Reference Dose, Abou-Donia et al., 1980 , NOEL/LOAEL, hen, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 27(8), 97,1962 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.21 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Merphos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 820 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 9 12 # PWSs/Sites/ Samples 94 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2 % Samples with detects Number of States 1 1 % PWSs/Sites/ Sam pies with detects 2.13 Minimum value of Detects Units States States States Minimum value of Detects 1.5 Non-cancer: 0.05 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 4.3 Median value of Detects 90% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L 99% of Detects ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2.9 90% of Detects 4.02 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Cancelled herbicde (HSDB) Value 8.7 days 62,400 7.67 2.27E-05 0.0035 6 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (PBT) ------- Methacrylamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 821 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methacrylamide 2883 79390 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 12.5 451 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect Decreased body weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, _ 7 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger PI. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year 47,179,1981 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 87.5 Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methacrylamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 822 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Polymer intermec Value 15 days 40 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (OECD/SIDS) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Methacrylic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 823 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methacrylic acid 2885 79414 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5 1,060 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1973 1976 Critical Effect Behavioral - alteration of classical conditioning Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 0 , „ 8 5 NL' L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see H YSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)Jpage/year 38(8),13,1973 Supplemental Data GISAAA Gigiena i Sanitariya. For English translaton, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095Moscow, USSR) V.1- 1936- Volume(issue)/page/year 41(4), 6,1976 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 11.7 Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of wa er consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methacrylic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 824 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Polymer intermediate for resins and coatings (HSDB) Value 15 0.93 3.90E-07 89,000 40 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Methacrylonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 825 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methacrylonitri e 5635 126987 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 0.001 7.5 60 64 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Transient increase in SGOT & SGPT (liver enzyme) levels; liver enzyme changes increased SGOT and SGPT levels Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose, Pozzani et al., 1968, NOAEL 9 mg/m3. Dog, UF=3000 Reference Dose Reference Dose, Pozzani, 1968, NOAEL/LOAEL.dog, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB97-1 76390 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methacrylonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 826 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,603 # Sam pies Amount Released 0 89,330 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 0 3 % PWSs/Sites with detects Not Detected Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-500M >10M-500M Polymer intermec Value 15 days 12.8 0.68 2.47E-04 25,400 49 Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Methional CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 827 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methional 14647 3268493 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,580 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 Critical Effect Sense Organs and Special Senses (Eye) - lacrimation, Lungs, Thorax, or Respiration - dyspnea, Lungs, Thorax, or Respiration -other changes Prevalence Magnitude 8 7 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year 42,77,2000, LD50 of 1.52 mL/kg converted to mg/kg using a density of 1.041 g/mL (Aldrich Chemical). Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methional CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 828 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Natural flavoring agent; (American Chemical Society/C&E News) Value 1 5 days 47 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Methomyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 829 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methomyl 25598 16752775 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.025 0.025 0.025 0.025 0.02 0.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 1989 Critical Effect Histopathological effects in the kidney kidney, spleen kidney, spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 2 7 NLi HRL Ratio(s) NC HRL/NCOD R2 90%: 106 Notes Reference Dose Reference Dose, duPont 1968, NOEL 2.5 mg/kg-d, dog, UF=100 Reference Dose Reference Dose, duPont 1968, NOEL/LEL, dog, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; JDGRAX Journal of Drug Research. (National Organ zation for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issueVoaae/vear 18.145.1989 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification E mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1988 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.9 175 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methomyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 830 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,659 18 0.1422 Not Detected 3 1.65 1.65 3 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,506 # Sam pies Amount Released 1,997,489 # PWSs/Sites sampled 134 495 # PWSs/Sites/ Samples 4,611 17 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 #with Detects 1 0.377 % Samples with detects Number of States 42 % PWSs/Sites with detects 0 % PWSs/Sites/ Sam pies with detects 0.02 0.0044 Minimum value of Detects Units States States States Minimum value of Detects Minimum value of Detects 15 Non-cancer: 106 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.0 Maximum value of Detects Year 1997 Maximum value of Detects Maximum value of Detects 15 0.22 Median value of Detects 0.47 90% of Detects 1.0 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 15 99% of Detects 90% of Detects 15 Units for Mag data Units for Mag data ug/L Cancer: Notes 2001 2002 9060 (HPLC/MS) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Insecticide (HSDB) Value 5 days 12.01 0.6 1.97E-11 58,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Methotrexate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 831 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Methotrexate 2369 59052 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.1 0.00435 0.5 180 135 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 1981 1982 Critical Effect Liver - hepatitis (hepatocellular necrosis), zonal Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.23 Y/N Y/N mg/L W/L W/L Developmental; Teratogen Prevalence Magnitude ,,, „ 1 1 NL' HRL Ratio(s) No data for calcuating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; HPTLD9 Hepatology (Baltimore). (Williams & Wilkins Co., Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/pagefyear 14,906,1991; 6-week study in rat Maximum Recommended Daily Dose (MRDD) IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V26 275 (1981); Study in rat Lowest Observed Adverse Effect Level; NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year 6,841,1982; Oral study in rat CACART CACART; UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Methotrexate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 832 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREG ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Focazio, etal., 2008 HRL Ratios (No data for calcuating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 26 Amount Released # PWS/Sites/ Samples 0 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States % PWS/Sites/ Samples with detects Not detected Units States States States Minimum value of Detects Not detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Not detected Year Maximum value of Detects Not detected Not detected Not detected Not detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects Not detected 90% of Detects Not detected Units for Mag data ug/L Notes Raw drinking water monitoring; Focazio, etal, 2008. Sci. Tot. Env ., 402(2-3): 201 -21 6. Cancer: Pharmaceutical Value 38 1 -1.85 1.50E-31 2,600 46 Units days L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades Slowly with Acclimation ------- Methyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 833 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyl acetate 2868 79209 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1 3,705 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1972 Critical Effect Increased alkaline phosphatase; liver Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA 1986, NOEL, Increased alkaline phosphatase, rat, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rabbit; IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher nformation, see IOHSA5. Volume(issue)/page/year 41,31,1972 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7,000 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 834 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; food additve; industrial solvent (HSDB) Value 1 5 days 3.32 0.18 0.000115 243,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Methyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 835 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyl acrylate 3829 96333 Attribute Scores Potency Severity 4 1 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 149 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1964 Critical Effect None observed Behavioral - fluid intake, Kidney, Ureter, Bladder - changes in bladder weight, Nutritional and Gross Metabolic - weight oss or decreased weight gain 3-model Categorical Prediction NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA, 1987, NOEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year6,29,1964 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 1990 1999 Vol. 39, Suppl. 7; Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl acrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 836 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,603 # Sam pies Amount Released 728 206,487 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 5 20 % PWSs/Sites with detects Not Detected Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Polymer intermec Value 6.42 0.8 0.000197 49,400 Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate; in adhesive formulations (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Methyl carbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 837 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyl carbamate 8351 598550 Attribute Scores 3-model Categorical Prediction Potency Severity 4 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 71.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - leukemia, Tumorigenic - active as anti-cancer agent Prevalence Magnitude 5 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)Apage/yearPB88-168570/AS Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 1987 Vol. 12, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 167 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl carbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 838 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 1 5 days 10 -0.66 4.00E-08 691,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Methyl mercaptan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 839 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyl mercaptan 2609 74931 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 61 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Prevalence Magnitude 10 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 688 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl mercaptan CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 840 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; natural gas additive (HSDB); gas Value 14.3 0.78 3.13E-03 15,400 75 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Methyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 841 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyl methacrylate 2958 80626 Attribute Scores 3-model Categorical Prediction Potency Severity 2 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1.4 1.4 0.05 0.357 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 1976 Critical Effect None, Marginally significant increase in kidney to body weight ratio. Decreased Potency Score by one integer kidney Brain and Coverings - other degeneratve changes, Liver - other changes, Biochemical - Enzyme nhibition, induction, or change in blood or tissue levels - transaminases Prevalence Magnitude ,,, 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Borzelleca et al., 1864, NOEL 136 mg/kg-d, rat, UF=100 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake, Borzelleca et al., 1964, NOEL, rat, UF=100 Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 39-week oral study in rabbit; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year41(4),6,1976 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification E 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1997 1994 Vol. 60 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 9,800 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 842 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,603 # Sam pies Amount Released 2,408 3,657,567 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 8 39 % PWSs/Sites with detects Not Detected Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Polymer intermec Value 10.14 1.38 0.000338 15,000 Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Methylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 843 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methylamine 2607 74895 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1390 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 75 L' L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 1 1 New Fetter Lane, London EC4P4EEJV.1- 1989- Volume(issue)/page/year 2,29,1990 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 844 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ntermediate for accelerators, dyes, Pharmaceuticals, insecticides, tanning; fuel additive (HSDB) Value 389 0.57 1.11E-05 1,250,000 48 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Methylcyclopentadienyl manganes CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 845 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methylcyclopentadienyl manganese tricarbonyl 22045 12108133 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20T 8 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 1976 Critical Effect Kidney, Ureter, Bladder - other changes in urine composition, Blood - changes in serum composition e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 Incomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year 23,473,1 992 Supplemental Data TMMT "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976 Volume(ssue)/page/year -,-,1976 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 482 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methylcyclopentadienyl manganes CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 846 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Fuel additive (HSDB); gas Value 3.7 29 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Methyleugenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 847 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyleugenol 3608 93152 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 0.0714 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 2001 Critical Effect Increased liver weights, decreased body weight gain Endocrine - changes in spleen weight, Blood - changes in platelet count, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Prevalence Magnitude ,,, 1 3 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental NOEL, Abdo, et al. 2001. Food and Chemical Toxicology 39 (2001) 303-316. Lowest Observed Adverse Effect Level; 1 4-week oral study in rat; FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year39,303,2001 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 Y/N Y/N M8/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyleugenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 848 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10K-500K >10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; flavorant; insect attractant (HSDB) Value 34 hours 140 3.03 5.60E-06 500 19 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Methylglutaronitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 849 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methylglutaronitrile 16055 4553622 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1969 Critical Effect Behavioral - convulsions or effect on seizure threshold, Behavioral - excitement, Lungs, Thorax, or Respiration - cyanosis. Prevalence Magnitude , „ , 6 7 L"L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.I -25, 1951-75. Volume(issue)/page/year 19,225,1969 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methylglutaronitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 850 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; solvent (HSDB) Value 15 days 10.7 -0.644 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Methyltrichlorosilane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 851 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Methyltrichlorosilane 2682 75796 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981-1982 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 8 5 L"L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2398 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Methyltrichlorosilane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 852 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 50M-10M 100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value rapid 40 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Metiram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 853 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Metiram 20233 9006422 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.004 0.03 73.9 620 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993 2000 1980 Critical Effect Decrease forelimb grip strength Endocrine - changes in thyroid weight, Blood - changes in erythrocyte (RBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 9 7 L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake, Group ADI with MANCOZED, MANEB AND ZINEB Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in rat; TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41 , Jan. 1 998- Volume(issue)/page/year 54,481 ,2000 Supplemental Data VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year 56(6),59,1980 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 28 Y/N Y/N W/L W/L Developmental CACART CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Metiram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 854 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 1,385,330 OPP Estimated Environmental Concentration HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr % Samples with detects Number of States 24 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 Surface water chronic: 0 ug/L Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 0 ug/L Cancer: Fungicide (HSDB) Value 100,000 0.3 9.30E-18 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Metribuzin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 855 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Metribuzin 27143 21087649 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.013 0.025 0.025 0.025 0.617 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect ncreased absolute & relative thyroid weight, increased T4, decreased T3 in blood. Liver; kidney; body weight; mortality Brain and Coverings - other degeneratve changes Prevalence Magnitude 1 7 HRL Ratio(s) NC HRL/NAWQA AW 90% : 45.5 Notes Reference Dose, Mobay Chemical, 1974a Reference Dose, Mobay Chemical, 1974a, NOEL 2.5 mg/kg-d, dog, UF=100 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1 5-week oral study in rat; JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volumefissuel/Daae/vear 30.209.1990 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL CADW MAC Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.9 80 91 Y/N Y/N W/L W/L W/L Drinking Water Equivalent Level Canadian Drink ng Water Maximum Acceptable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Metribuzin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 856 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,568 9 0.0663 0.1 2 1.1 2 2 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP Supplemental Water Data PPMP PPMP Supplemental Water Data CAL DHS HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,165 # Sam pies Amount Released 3,320,231 24 847 # PWSs/Sites/ Samples 288 582 # PWSs/Sites/ Samples # PWSs/Sites/ Samples 7,281 459 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 1 #with Detects 47 0 #with Detects 1 6.41 % Samples with detects Number of States 48 2 3 % PWSs/Sites/ Sam pies with detects 0.3 % PWSs/Sites/ Samples with detects 14.6 0 % PWSs/Sites/ Samples with detects 0.01 0.002 Minimum value of Detects Units States States States Minimum value of Detects 0.042 Minimum value of Detects Minimum value of Detects 4 Non-cancer: 45.5 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 6.61 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.042 Maximum value of Detects Maximum value of Detects 4 0.022 Median value of Detects 0.24 90% of Detects 2.26 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.042 Median value of Detects Median value of Detects 4 99% of Detects 0.042 95% of Detects 0.004 90% of Detects 4 Units for Mag data ug/L ug/L Units for Mag data ug/L ug/L Units for Mag data ug/L Cancer: Notes 2001 2002 Notes 2001 raw water (GC/MS) 2001 finished water (GC/MS) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Herbicide (HSDB) Value 1,196 1.7 1.17E-10 1,050 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Molybdenum trioxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 857 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Molybdenum trioxide 11108 1313275 Attribute Scores Potency Severity 5 5 Prevalence Magnitude 9 8 Scores based on parent Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased uric acid levels (for molybdenum) 3-model Categorical Prediction L? HRL Ratio(s) NCHRL/NIRS90%: 1.10 Notes Reference Dose Reference Dose, U.S. EPA, 2003 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Molybdenum trioxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 858 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 77 7.79 6.1 180 10 30 110 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 36,579 2,102,324 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 18 36 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 1.10 Amount Range 10M-50M Catalyst; chemica Value 1,066 Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes Scores based on parent (molybdenum) National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes intermediate (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- N.N'-Diethylthiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 859 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N.N'-Diethylthiourea 4461 105555 Attribute Scores Potency Severity 6 9 Prevalence Magnitude 1 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 316 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1973 Critical Effect Details of toxic effects not reported other than lethal dose value 3-model Categorical Prediction L? HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (NCILB Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) Volume(issue)/page/year NCI-E-C-72-3252,1 973) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Vol 79; 2001 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N M8/L W/L IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- N.N'-Diethylthiourea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 860 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rubber accelerator; corrosion inh bitor (HSDB) Value 1 5 days 49 0.57 6.85E-08 4,555 47 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- N, N-Dimethylacetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 861 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N, N-Dimethylacetamide 5644 127195 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.583 65 2 4,390 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1980 Critical Effect decreased fetal body weights in the absence of maternal toxicity Liver - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - other esterases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Prevalence Magnitude 6 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Maximum Recommended Da ly Dose (MRDD) No Observed Effect Level Supplemental Data, Johannsen etal 1987 Lowest Observed Adverse Effect Level; 26 week rat study Supplemental Data Kennedy, GL Jr, Sherman H; Drug ChemToxicol9 (2): 147-70(1986); Prager, J.C. Environmental Contaminant Reference Databook, Volume 1. New York, NY: Van Nostrand Reinhold; rat Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 455 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N, N-Dimethylacetamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 862 of 1124 OCCURRENCE DATA # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent (HSDB) Value 9 -0.77 1.31E-08 1,000,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (HSDB) ------- N,N-Dimethylethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 863 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N,N-Dimethylethanolamine 4658 108010 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 450 15 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect increased liver and kidney weights Prevalence Magnitude 7 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, NTP summary of tox literature. NOAEL 450 mg/kg/day (Smyth etal, 1951 Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Da ly Dose (MRDD) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3,150 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- N,N-Dimethylethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 864 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Medication; chem Value -0.94 3.73E-07 1,000,000 40 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L u ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes cal intermediate; stabilizer (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Naled CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 865 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Naled 6448 300765 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 21.4 92 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1969 1990 Critical Effect Brain ChE inhibition Brain cholinesterase nhibition ChE inhibintion Nutritional and Gross Metabolic - body temperature decrease, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase, Related to Chronic Data - death Behavioral - tremor, Gastrointestinal - changes in structure or function of salivary glands, Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude , „ 96 L HRL Ratio(s) NC HRL/SWC EEC: 25 Notes Reference Dose Reference Dose, Chevron Chem cal Co., 1984a, NOEL 0.2 mg/kg-d, rat, UF=100 Reference Dose Reference Dose, Chevron Chem cal Co., 1984a, NOEL/LEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 9-week oral study in rat; RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB1001, 00-068 Warsaw 1 , Poland) V.1- 1950- Volume(issue)/page/year20,463,1969 Supplemental Data Rat; ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year 1,90,1990 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Naled CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 866 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS # Sam pies Amount Released 605,456 0 0 # PWSs/Sites/ Samples 14 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 16 0 0 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Surface water chronic: 0.56 ug/L Non-cancer: 25 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.005 ug/L Cancer: nsecticide; veter nary medicine (HSDB) Value 96.03 1.38 6.51 E-05 1.5 37 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Naphthalene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 867 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Naphthalene 3465 91203 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 0.02 0.6 60 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1970 Critical Effect Decreased terminal body weight Decreased mean terminal body weight in males Neurol. Endocrine - changes in adrenal weight Prevalence Magnitude 7 6 NLi HRL Ratio(s) NC HRL/NCOD R1 90%: 17.5 Notes Reference Dose Reference Dose, BCL 1980, NOAEL 100 mgflsg-d; adjusted NOAEL 71 mg/kg-d, rat, UF=3000 Reference Dose Reference Dose, BCL 1980, NOAEL/LOAEL, rat, UF=3000 Minimal Risk Level-lnt. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 28-day oral study in rat; BIOFX BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year 16- 4/1970 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification C 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.7 140 Y/N Y/N W/L W/L Teratogen CACART; IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Naphthalene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 868 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 13,452 22,926 159 176 1.18 0.768 0.03 0.07 906 90 1 0.736 8 3.1 900 73 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,310 85 # Sam pies Amount Released 17,809 3,456,696 # PWSs/Sites/ Samples sampled 10,913 83 14 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 20 1.926 16.5 % Samples with detects 6.31 1.35 Number of States 41 53 % PWSs/Sites/ Samples with detects 0.18 0.005 Minimum value of Detects Units States States States Minimum value of Detects 0.008 Non-cancer: 17.5 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 70 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 7 0.072 0.020 Median value of Detects 0.135 0.9 0.7 90% of Detects 43 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.88 90% of Detects 4.07 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; chemical intermediate; moth repellant (HSDB) Value 38 days 1,837 3.3 0.00044 31 13 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- n-Butyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 869 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): n-Butyl acetate 5537 123864 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 14,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1993-1994 Critical Effect Paper by Davis et al, suggests that n-butanol data are appropriate for the effects of n-butylacetate since n- butylacetate are readily hydrolyzed to n-butanol. In an inhalation study, there was some minor evidence of gastric irritation from the n-butyl acetate. Prevalence Magnitude 8 5 NLi HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, ZC, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2980 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- n-Butyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 870 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; flavoring additive; industrial solvent (HSDB) Value 200 1.78 0.00028 14,000 33 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- n-Butyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 871 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): n-Butyl methacrylate 3916 97881 Attribute Scores Potency Severity 5 6 Prevalence Magnitude 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 30 3.57 12,900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1976 1976 Critical Effect Spleen toxicity, decreased absolute and relative weights of the spleen. Brain and Coverings - recordings from specific areas of CNS, Behavioral - alteration of classical conditioning, Liver - other changes; Blood - pigmented or nucleated red blood cells, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - catalases Details of toxic effects not reported other than lethal dose value 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 39-week oral study in rat and rabbit; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 41(4), 6,1976 Supplemental Data Mouse; GISAAA Gigiena i Sanitariya. Kniga, 113095 Moscow, USSR) V.1- -or English translation, see HYSAAV. (V/O Mezhdunarodnaya 1 936- Vo ume(issue)/page/year 41 (4) ,6, 1 976 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- n-Butyl methacrylate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 872 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-SOM Polymer intermec Value 8.7 days 880 2.88 0.00079 24 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Neopentyl glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 873 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Neopentyl glyco 5606 126307 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased liver weight; increased kidney weight Prevalence Magnitude 8 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Neopentyl glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 874 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (Merck Index, 1983) Value 0.16 44 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Nickel CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 875 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Nickel 18829 7440020 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 Critical Effect Decreased organ (kidney, liver & spleen) & body weights Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 1 mg/L (mg/kg-d)-1 (mg/kg-d)-1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.7 140 Y/N Y/N mg/L W/L W/L 1995 Teratogen Prevalence Magnitude , „ 98 L HRL Ratio(s) NCHRL/NIRS90%: 0.74 Notes Reference Dose Reference Dose Reference Dose Reference Dose; IRIS Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data OEHHA, Class A Vol. 49; 1 997; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Nickel CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 876 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 47 4.75 5 150 7.6 190 110 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 3,298 Amount Released 29,802 6,119,051 # PWSs/Sites sampled 2,171 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 65.8 Number of States 37 49 % PWSs/Sites with detects 0.03 Units States States States Minimum value of Detects Non-cancer: 0.74 Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 666 Year 2004 2004 Maximum value of Detects 2 6 29.7 Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggragate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Use data are for n ckel sulfate: Steel making, catalysts, storage batteries, specialty chemica s, and specialty ceramics (HSDB); naturally-occurring Value 389,900 Units length of time cm3/g unitless cm3/g unitless mg/L Degradation Code BST Notes assume persistent; all use and env. fate data are for nickel sulfate; BST = biodegrades sometimes/recalcitrant ------- Nickel compounds CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 877 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Nickel compounds 44 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 10 10 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased body and organ weights 3-model Categorical Prediction L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose, Rat chronic oral study, Ambrose et al, 1 976 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 1 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1990 Vol. 49 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 140 Y/N Y/N W/L W/L Teratogen IARC UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nickel compounds CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 878 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 170,937 34,676,669 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 45 52 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Electroplating; steel additives (HSDB) Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Niobium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 879 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Niobium 18830 7440031 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 316 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect hyperplasia and hyperkeratosis of the stomach Prevalence Magnitude 5 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data, OPPTS summary LOAEL 316 mg/kg/day ammonium niobium dioxylate oxide pentahydrate. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 8.03E-13 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 22.1 Y/N Y/N W/L W/L RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Niobium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 880 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n alloys; in nuclear reactions (Merck Index, 1983) Value 350 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Nitrilotriacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 881 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Nitrilotriacetic acid 5991 139139 Attribute Scores Potency Severity 5 6 Prevalence Magnitude 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 1.05 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1979 Critical Effect Increased incidence of nephritis & nephrosis, hyperglycaemia Kidney, Ureter, Bladder - other changes in urine composition, Kidney, Ureter, Bladder - changes in bladder weight, Nutritional and Gross Metabolic - changes in calcium 3-model Categorical Prediction NL? - L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data, Health Canada ADI No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 4-week oral study in rat; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year 17,137,1979 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0053 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol. 73 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL WHODWQ Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 200 70 Y/N Y/N W/L W/L W/L CACART; IARC; OEHHA Drinking Water Equivalent Level World Health Organization Drink ng Water Quality Value 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- Nitrilotriacetic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 882 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 14,494 30,679 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M >10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chelating agent; in detergents (HSDB) Value 8.7 days <286 -3.8 59,100 34 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- Nitrofen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 883 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Nitrofen 12291 1836755 Attribute Scores 3-model Categorical Prediction Potency Severity 7 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.17 49.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1983 Critical Effect Neonatal effects Liver - changes in liver weight Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.082 B2 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1.19 0.427 Y/N Y/N M8/L W/L Prevalence Magnitude , „ 1 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Toxicology Volume 29, Issue 1-2, December 1983, Pages 1-37; Lowest Observed Adverse Effect Level; 2-year oral study in mammal; FCTXAV Food and Cosmetics Toxicology. (London, UK) V. 1-1 9, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year 10,427,1972 Supplemental Data CACART; EPA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitrofen CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 884 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 25,300 # PWSs/Sites sampled Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States 0 1 % PWSs/Sites with detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2002 2002 Maximum value of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (NTP) Value 4,400 5.534 6.74 E-05 0.7-1.2 9 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation code BSA Notes BSA = biodegrades slowly with acclimation ------- Nitromethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 885 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Nitromethane 2658 75525 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 12.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect Behavioral - alteration of classical conditioning, Blood • changes in serum composition (e.g. TP, bilirubin, cholesterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Prevalence Magnitude 6 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/pagefyear32(9),9,1967; 26-week oral study in rabbit Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 2000 Vol. 77 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 29.2 Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Nitromethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 886 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rocket fuel; industrial solvent (HSDB) Value 15 -0.35 2.86E-05 111,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (HSDB) ------- N-Methylolacrylamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 887 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N-Methylolacrylamide 10095 924425 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 12.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1989 Critical Effect Behavioral - ataxia, Liver - changes in liver weight, Related to Chronic Data - changes in testicularweight Prevalence Magnitude .,,„,-, 8 5 NL!'L! HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year NTP-TR-352,1989 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)-1 1994 Vol. 60 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 29.2 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Methylolacrylamide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 888 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 1,121 12,306 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 3 13 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Monomer; proposed for use in sunscreen (HSDB) Value 15 days -1.81 9.45E-12 653,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- N-Nitroso-di-n-butylamine (NDBA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 889 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitroso-di-n-butylamine (NDBA) 10094 924163 Attribute Scores 3-model Categorical Prediction Potency Severity 7 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0006 5.4 11 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1986 1987 Bladder, esophagus Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.006 Y/N Y/N W/L W/L Prevalence Magnitude 1 1 NLi HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data OEHHA incorrectly lists EPA cancer classification as "A." CACART; EPA; OEHHA; RAIS; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitroso-di-n-butylamine (NDBA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 890 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released 0 5 # PWSs/Sites/ Samples 131 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States 0 1 % PWSs/Sites/ Samples with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year 2004 2004 Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggragate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units ug/L Notes Cancer: Research chemical (HSDB) Value 15 642 2.63 1.32E-05 1,200 26 Units days cm3/g unitless cm3/g atm-m3/mol mg/L Degradation Code BS Notes PBT; BS = Biodegrades Slowly ------- N-Nitrosomethylethylamine (NMEA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 891 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): N-Nitrosomethylethylamine (NMEA) 21341 10595956 Attribute Scores Potency Severity 8 8 Prevalence Magnitude Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 0.0002 22 22 B2 2B mg/L (mg/kg-d)-1 (mg/kg-d)"1 1987 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.0016 Y/N Y/N W/L W/L 3-model Categorical Prediction HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data IRIS CACART; EPA; RAIS; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitrosomethylethylamine (NMEA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 892 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data STORE! HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples 21 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 Number of States % PWSs/Sites/ Samples with detects 0 Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggragate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units ug/L Notes Cancer: Research chemical (HSDB) Value 38 25 0.04 1.40E-06 300,000 52 Units days cm3/g unitless cm3/g atm-m3/mol mg/L Degradation Code BSA Notes PBT; BSA = Biodegrades Slowly with Acclimation ------- N-Nitroso-N-methylurea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 893 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): N-Nitroso-N-methylurea 9372 684935 Attribute Scores 3-model Categorical Prediction Potency Severity 9 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2.86 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 Critical Effect Musculoskeletal - changes in teeth and supporting structures Prevalence Magnitude 1 1 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 16-week oral study in hamster; TOPADD Toxicologic Pathology. (c/o Dr. F.A. de a Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, Ml 48106) V.6(3/4)- 1978- Volume(issue)/page/year 27,226,1999 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 120 B2 2A mg/L (mg/kg-d)-1 (mgftg-d)-1 (mg/kg-d)"1 1987 Vol. 17, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.000292 Y/N Y/N W/L W/L Teratogen OEHHA; EPA; IARC; CACART UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- N-Nitroso-N-methylurea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 894 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 5 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Synthetic intermediate; potential anti-neoplastic (HSDB) Value 15 days 18.55 -0.03 9.91 E-11 14,400 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Norflurazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 895 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Norflurazon 30023 27314132 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.015 0.04 0.04 8,000 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1977 Critical Effect Increased cholesterol, absolute & relative liver weight Liver; thyroid Liver; thyroid Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 5 NLi HRL Ratio(s) NC HRL/NAWQA AW 90% : 84.7 Notes Reference Dose Reference Dose; Sandoz-Wander, 1973; Basis NOEL 3.75 mg/kg-d, dog, UF = 100 Reference Dose Reference Dose; Sandoz-Wander, 1973; Basis NOEL/LEL, dog, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat; 85ARAE "Agricultural Chemicals, "Thomson, W.T., 4vols., Fresno, CA, Thomson Publications, 1976/^ Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 105 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Norflurazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 896 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP finished water POP finished water PPMP finished water HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,557 # Sam pies Amount Released 2,459,703 0 0 # PWS/Sites/ Samples 154 288 71 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 1.56 % Samples with detects Number of States 30 0 0 % PWS/Sites/ Samples with detects 0 0.004 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 84.7 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 44 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected 0.21 Median value of Detects 1.24 90% of Detects 26.5 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Cancer: Herbicide (HSDB) Value 60 days 5,674 2.3 3.43E-10 33.7 17 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- o-Chloronitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 897 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Chloronitro benzene 3327 88733 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 88.9 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect methemoglobinemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude 6 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Bio/Dynamics, Inc. 1985; Basis NOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 27-week oral study in mouse; NTIS National Technical nformation Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical nformation. Volume(issue)/page/year PB92-187608/AS Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0097 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1996 Vol65 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7 Y/N Y/N W/L W/L RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Chloronitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 898 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 315.5 2.24 9.30E-06 441 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- o-Chlorotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 899 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Chlorotoluene 3764 95498 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.02 0.02 570 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1981 Critical Effect Decreased body weight gain Decreased body weight gain Liver - liver function tests impaired, Kidney, Ureter, Bladder - renal function tests depressed, Blood - other changes Prevalence Magnitude ,,, „ 3 6 NL' HRL Ratio(s) NC HRL/NCOD R2 90%: 46.7 Notes Reference Dose Reference Dose; Gibson et al., 1974a Basis NOAEL 20 mg/kg-d, rat, UF=1000 Reference Dose Reference Dose; Gibson et al., 1974a Basis NOAEL/LOAEL 20 mg/kg-d, rat, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 9-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 46(2), 67,1 981 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.7 140 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- o-Chlorotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 900 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 15,721 24,118 32 34 0.204 0.141 0.06 0.3 16.4 52.4 0.57 0.68 3 4.4 16.4 52.4 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R2 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 # Sam pies Amount Released # PWS/Sites/ Samples 11,883 19 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 6 0.441 % Samples with detects Number of States % PWS/Sites/ Samples with detects 0.05 0.004 Minimum value of Detects Units States States States Minimum value of Detects 0.6 Non-cancer: 46.7 Amount Range >10M-50M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 0.356 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 24 0.0195 Median value of Detects 0.05 90% of Detects 0.356 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 7.9 90% of Detects 17.5 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Solvent; chemica intermediate; insecticide (HSDB) Value 443 3.42 0.00357 374 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- Octamethylcyclotetrasiloxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 901 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Octamethylcyclotetrasiloxane 7887 556672 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,540 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -tremor Prevalence Magnitude .,, „ 8 5 NL!'L! HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0538262 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 108 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Octamethylcyclotetrasiloxane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 902 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in PPCPs; food additive; in fermentation (HSDB) Value 38 days 14,000 5.1 0.117 0.005 10 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- o-Dianisidine dihydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 903 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Dianisidine dihydrochloride 26927 20325400 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 33 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Blood - other changes, Liver - changes in liver weight, Kidney, Ureter, Bladder - changes in bladder weight Prevalence Magnitude 1 1 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issueypagefyear NTP-TR-372,1990. 39 week study in rat. Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 77 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Dianisidine dihydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 904 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 29 46 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Biochemical reagent (SigmaAldrich - manufacturer) Value 38 days 44 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- o-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 905 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Dinitrobenzene 7498 528290 Attribute Scores Potency Severity 7 3 Prevalence Magnitude 1 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHERfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased spleen weight 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Cody etal. 1981; Basis NOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1992 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.7 Y/N Y/N W/L W/L Reproductive CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- o-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 906 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release -total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 102,329 105,280 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 225 1.69 3.69E-07 500 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- o-Nitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 907 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Nitrotoluene 3326 88722 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 37.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 2003 Critical Effect Blood- elevated methemoglobin, anemia. Spleen- splenic hemosiderosis, splenomegaly, splenic histopathology Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , „ 6 5 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; USEPA 1986; Basis LOAEL, rat, UF=10000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 15-week oral study in rat; TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ire and) V.1- 1973- Volume(issue)/page/year 183.221.2003 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.23 3 mg/L (mgftg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1996 Vol. 65 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 70 0.15 Y/N Y/N W/L W/L CACART; RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Nitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 908 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for petrochemicals, pesticides, dyes and Pharmaceuticals. n(HSDB) Value 315.5 2.3 1.25E-05 650 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- o-Toluidine hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 909 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): o-Toluidine hydrochloride 9161 636215 Attribute Scores 3-model Categorical Prediction Potency Severity 6 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver - other changes, Liver - changes n liver weight, Related to Chronic Data - changes in testicular weight; Kidney, Ureter, Bladder - changes in bladder weight, Endocrine - changes in spleen weight, Nutritional and Gross Metabolic - we ght loss or decreased weight gain Prevalence Magnitude 2 1 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week and 13-week oral study in rat; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- Volume(issue)/page/yearNIH-96-3936 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.18 0.13 B2 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 700 0.27 Y/N Y/N W/L W/L CACART; RAISHE; OEHHA; EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- o-Toluidine hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 91 Oof 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 22 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Dye intermediate (HSDB) Value 15 days 74.04 1.32 1.98E-06 16,600 41 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Oxadiazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 911 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Oxadiazon 26706 19666309 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0036 0.005 0.005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect ncreased level of serum protein increased liver weight, incidence of swollen cells in central lobe of the liver. ncr. serum proteins; ncr. liver weights ncreased levels of serum protein and increased liver weight 3-model Categorical Prediction NL? HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose; OPP Reference Dose; Rhone-Poulenc, 1981; Basis NOEL 0.5 mg/kg-d, rat, UF=100 Reference Dose Reference Dose; Rhone-Poulenc, 1981; Basis NOEL/LEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.071 1 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 25.2 0.49 Y/N Y/N W/L W/L Reproductive CACART; EPA CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Oxadiazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 912 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release -total Supplemental Water Data POP POP HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 28,822 # PWS/Sites/ Samples 154 317 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWS/Sites/ Samples with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Cancer: Herbicide (HSDB) Value 3,500 4.8 7.27E-08 0.7 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- Ozone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 913 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Ozone 20667 10028156 Attribute Scores Potency Severity Prevalence Magnitude 9 8 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Ozone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 914 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 715,830 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 20 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Air and water dis nfectant; chemica intermediate (HSDB); Naturally-occurring gas Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- p,p'-DDE CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 915 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p,p'-DDE 2587 72559 Attribute Scores Potency Severity 6 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 0.0005 12 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1984 2000 1996 Critical Effect Liver - changes in liver weight, Immunological Including Allergic - decrease in cellular immune response, mmunological Includ ng Allergic - decrease in humoral immune response 3-model Categorical Prediction NL-NL? HRL Ratio(s) NC HRL/UCMR 90%: 0.03 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 6-week oral study in rat Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.01 0.34 0.34 B2 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1988 IRIS Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.1 Y/N Y/N W/L W/L CACART; EPA; RAISHE; OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- p,p'-DDE CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 916 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 3,867 1 0.0259 3 3 3 3 3 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS POP POP PPMP HRL Ratios (HRL/UCMR 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,117 # Sam pies Amount Released # PWSs/Sites/ Samples 2,672 288 688 457 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 6 6.42 % Samples with detects Number of States % PWSs/Sites/ Sam pies with detects 0 2.6 0.001 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: 0.03 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.062 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected 0.006 0.002 Median value of Detects 0.0095 90% of Detects 0.025 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Prgram (USGS/EPA) 2001(GC/MS) Product of degradation of DDT (HSDB) Value 180 days 153,000 6.51 4.16E-05 0.04 1 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Paraquat CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 917 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Paraquat 16146 4685147 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0045 0.004 0.93 25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 2001 1979 Critical Effect Lungs, Thorax, or Respiration - other changes, chronic pneumonitis Lungs, Thorax, or Respiration - other changes Prevalence Magnitude , „ , 10 8 L' L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year oral study in dog; FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year 66, 48593, 2001 Supplemental Data IYKEDH lyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year 10,520,1979 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 31.5 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Paraquat CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 918 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 6,884,630 # PWSs/Sites/ Samples 519 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 48 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former herbicide (HSDB) Value 38 days 15,473-1,000,000 -4.22 <1E-09 46 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- p-Chloronitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 919 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Chloronitro benzene 4072 100005 Attribute Scores Potency Severity 7 3 Prevalence Magnitude 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.177 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg mg/kg mg/kg Date ZOOS Critical Effect Decreased red blood cell count 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve Supplemental Data; Journal; Matsumoto et al., 2006 BMDL10=0.177 mg/kg/day Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1996 Vol. 65 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.41 Y/N Y/N W/L M8/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- p-Chloronitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 920 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (HSDB) Value 151-476 2.39 453 22 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- p-Chlorotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 921 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Chlorotoluene 4533 106434 Attribute Scores Potency Severity 5 3 Prevalence Magnitude 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect Decreased body weight gain. Brain and Coverings - recordings from specific areas of CNS, Liver - hepatitis (hepatocellular necrosis), zonal, Liver - liver function tests impaired 3-model Categorical Prediction NL? HRL Ratio(s) NCHRL/NCODR1 90%: 70 Notes Reference Dose Reference Dose Reference Dose IRIS Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in rat Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.7 140 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- p-Chlorotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 922 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 15,612 21,378 27 25 0.173 0.117 0.02 0.2 6.4 22.5 0.5 0.5 2 5 6.4 22.5 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 # Sam pies Amount Released # PWSs/Sites/ Samples 11,879 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2 0 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 0.02 Not Detected Minimum value of Detects Units States States States Minimum value of Detects 0.4 Non-cancer: 70 Amount Range >10M-50M >500K-1M Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 3 Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 1.7 90% of Detects 2.74 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Solvent; chemica intermediate (HSDB) Value 38 days 340 3.33 0.0044 106 20 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- p-Cresidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 923 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Cresidine 5344 120718 Attribute Scores Potency Severity 6 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL-NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.15 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1987 Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.23 Y/N Y/N W/L W/L CACART; OEHHA; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- p-Cresidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 924 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500K-1M 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; dye intermediate (HSDB) Value 38 days 53 1.74 1.20E-07 36 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- p-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 925 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Dinitrobenzene 4094 100254 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0001 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect ncreased spleen weight Prevalence Magnitude ,,, „ 1 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Codyetal 1981; Basis NOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.7 Y/N Y/N W/L W/L CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- p-Dinitrobenzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 926 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release -total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 28,100 28,71 1 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 1 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; dye constituent (HSDB) Value 221 1.46 3.69E-07 69 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Pentabromodiphenyl ethers CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 927 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pentabromodiphenyl ethers 31963 32534819 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 0.007 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 2004 Critical Effect Induction of hepatic enzymes nduction of hepatic enzymes Hepatic Prevalence Magnitude ,,, „ 6 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Carlson, 1980; Basis NOAEL 1.77 mgflsg-d, rat, UF=1000 Reference Dose Reference Dose; Carlson, 1980; Basis NOAEL/LOAEL, rat, UF=1000 Minimal Risk Level; Int. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pentabromodiphenyl ethers CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 928 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame retardant (HSDB) Value 30,500 7.66 3.55E-06 0.000079 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant ------- Pentachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 929 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pentachloroethane 2699 76017 Attribute Scores Potency Severity 4 3 Prevalence Magnitude 4 2 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 126 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect increased glucose excretion 3-model Categorical Prediction NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Lowest Observed Adverse Effect Level Supplemental Data, NTP, NIH Pub 96-3935, 1996 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1999 Vol. 41, Suppl. 7; Vol. 71 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 294 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 ~B cancer risk was used. ------- Pentachloroethane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 930 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 5 865 # PWSs/Sites/ Samples 429 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 1 4 % PWSs/Sites/ Sam pies with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range >1M-10M >10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 90% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.asox ndustrial solvent; chemical intermediate (HSDB) Value 180 days 1 1 7-244 500 13 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reclacitrant (PBT) ------- Pentaerythritol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 931 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pentaerythritol 5114 115775 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 2,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Diarrhea Prevalence Magnitude ,,, „ 8 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pentaerythritol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 932 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for resins, paints, Pharmaceuticals, insecticides (HSDB) Value 9 -1.69 4.10E-10 72,300 34 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (BIODEG) ------- Pentaerythritol dibromide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 933 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pentaerythritol dibromide 14700 3296900 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1980 Critical Effect Sense Organs and Special Senses (Eye) - effect, not otherwise specified Prevalence Magnitude ,,, „ 5 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82. Volume(issue);page/year 7,77,1980 Supplemental Data; Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 No quantitative data for the cancer endpoint were identified; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring." Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 233 Y/N Y/N M8/L W/L IARC; CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pentaerythritol dibromide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 934 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame retardant; polymer intermediate (HSDB) Value 420 2.29 4.10E-09 38,000 34 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (BIODEG) ------- Pentanal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 935 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pentanal 4865 110623 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No effect reported other than lethality. Prevalence Magnitude 4 8 Li HRL Ratio(s) NC HRL/NAWQA 90%: 26.4 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 2716 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 224 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pentanal CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 936 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR # PWSs/Sites sampled 236 #with Detects 1 % PWSs/Sites with detects 0.42 Mean value of Detects 8.5 Maximum value of Detects 8.5 Median value of Detects 8.5 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Mean value of Detects Non-cancer: 26.4 Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; rubber additive (HSDB) Value 8.7 1,040 1.31 0.000147 13.5 41 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BF = Biodegrades fast with acclimation ------- Phenolphthalein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 937 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phenolphthalein 2743 77098 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 400 400 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Liver - tumors, Tumorigenic - active as anti-cancer agent Hyperplasi of the parathyroid, fibrous osteodystrophy of the bone, hypersplais of the thyroid advanced nephropathy - clear evidence of cancer in mice and male rats-some evidence in female rats. Prevalence Magnitude ,,, 1 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/paqe/year Supplemental Data; NTP report TR-465. Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 2000 Vol. 76; Cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 933 Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phenolphthalein CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 938 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1994 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical reagent; medical indicator (HSDB) Value 38 days 490 2.41 9.00E-16 400 13 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Phenyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 939 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phenyl ether 4208 101848 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 2,450 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - food intake (animal), Behavioral - muscle weakness, Gastrointestinal - other changes Prevalence Magnitude ,,, „ 7 5 NL' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/pagefyear OTS0518143 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phenyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 940 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Synthetic intermediate; in PPCPs (Merck Index, 1983) Value 1,950 4.21 0.00028 18 ir Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Phenylmercury acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 941 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phenylmercury acetate 2433 62384 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00008 0.00008 0.625 13.3 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 2001 1980 Critical Effect Kidney damage at the LOAEL, kidney lesions at higher doses Kidney, Ureter, Bladder - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 5 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Fitzhugh et al., 1950; Basis NOAEL 0.0084 mg/kg-d, rat, UF=100 Reference Dose Reference Dose; Fitzhugh etal., 1950; Basis NOAEL/LOAEL, rat, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 2,1380,2001 Supplemental Data YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year 22,291,1980 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.56 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phenylmercury acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 942 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; disinfectant; drug preservative (HSDB) Value 171.8 0.71 5.65E-10 4,370 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Phenytoin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 943 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phenytoin 2317 57410 Attribute Scores 3-model Categorical Prediction Potency Severity 5 Prevalence Magnitude 1 5 Incomplete data for scoring HRL Ratio(s) HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL Supplemental ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20.5 5 4.3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Nutritional and Gross Metabolic - weight loss or decreased weight gain NC HRL/Vanderford MAX: 68.8 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; NTPTR National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Vo ume(issue)/page/year NTP-TR-404,1993 Maximum Recommended Daily Dose (MRDD) Minimum Therapeutic Dose (MTD) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) DSSTOX TD50 EPA Carcinogen classification ARC Carcinogen Classification 59.1 2B mg/L (mg/kg-d)"1 (mg/kg-d)"1 mg/kg-d 1996 Tumorigenic Dose - 50 Vol. 66; Cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potencv scorinq. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 11.7 Y/N Y/N M8/L W/L Developmental CACART CACART; UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phenytoin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 944 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data Snyder, 2008 Snyder, 2008 Vanderfordetal., 2006 HRL Ratios (HRL/Vanderford MAX) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 15,981 # PWSs/Sites/ Samples #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites/ Samples with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 68.8 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.032 0.04 0.17 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Finished Drinking Water Monitoring; Snyder, Shane A. 2008. Ozone: Science and Engineering. 30(1): 65-69. Raw Drinking Water Monitoring; Snyder, Shane A. 2008. Ozone: Science and Engineering. 30(1): 65-69. Ambient Water Monitoring; Vanderford etal., 2006 Env. Sci. &Technol. 40(23), pp. 7312-7320. Pharmaceutical (ChemlDPIus) Value 38 days 2.47 1.02E-11 32 16 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slowly with acclimation ------- Phosmet CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 945 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phosmet 9544 732116 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.011 0.02 0.02 0.01 26 Units mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1998 1969 Critical Effect RBC & serum ChE inhibition Red. Body weight; liver cell vacuolization; ChE inhibition Reduced bodywt; liver cell vacuolization; Cholinerase inhibition Behavioral - somnolence (general depressed activity), Behavioral - muscle contraction or spasticity, Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude 10 7 Li HRL Ratio(s) NC HRL/GWC EEC: 193 Notes Reference Dose Reference Dose; Stauffer Chemical 1967; Basis NOEL 2 mg/kg-d, rat, UF=100 Reference Dose Reference Dose; Stauffer Chemical 1967; Basis NOEL/LEL, rat, UF=101 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year 34(1-3), 192, 1969 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 77 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phosmet CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 946 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP CAL DHS # Sam pies Amount Released 1,333,468 # PWSs/Sites/ Samples 134 381 11 OPP Estimated Environmental Concentration HRL Ratios (HRL/GWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0 % Samples with detects Number of States 40 % PWSs/Sites/ Sam pies with detects 0 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Not Detected Surface water chronic: Non-cancer: 193 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected Not Detected 99% of Detects Not Detected Not Detected Units for Mag data ug/L ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) Ambient and finished water; method 9002 (GC/MS) Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Ground water chronic: 0.4 ug/L Cancer: nsecticide (HSDB) Value 38 days 42.9 2.78 8.39E-09 24.4 19 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Phosphorus CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 947 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phosphorus 19191 7723140 Attribute Scores 3-model Categorical Prediction Potency Severity 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00002 0.00002 0.00002 0.0002 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1997 1989 Critical Effect Parturition mortality; forelimb hair loss Behavioral - alteration of classical conditioning Prevalence Magnitude 10 10 HRL Ratio(s) NC HRL/NIRS 90%: 0.00037 Notes Reference Dose Reference Dose; Basis = NOAEL 0.015 mg/kg-d, UF = 1000, rat, oral (Condray, 1985) Reference Dose Reference Dose; Basis = NOAEL/LOAEL, MF = 1 , UF = 1 000, rat (Condray, 1 985) Minimal Risk Level; Int., oral, UF = 100, Endpoint = repro. Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 1990 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.0005 0.14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Phosphorus CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 948 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 392 39.6 42 555 104 381 1,576 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 8,090 # Sam pies Amount Released 4,457 31,102 # PWSs/Sites sampled 5,432 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 67.1 % Samples with detects Number of States 4 16 % PWSs/Sites with detects 1 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.00037 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Former pesticide; chemical intermediate; as ammunit Value 14.3 -0.27 3.5 0.0244 205,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code 11,000 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 44 Median value of Detects 270 90% of Detects 1,909 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes on (HSDB) Notes ------- Phthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 949 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Phthalic acid 3343 88993 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 105 0.56 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect Decreased body weight gain Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Prevalence Magnitude 5 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Journal - Toxicology Letters 93 (1997) 109-115. Ema, et al. Lowest Observed Adverse Effect Level; 26-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 32(8), 12,1 967 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 733 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Phthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 950 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1994 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide (HSDB) Value 2.5-5 weeks 2-31 0.73 2.00E-11 6,965 36 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (HSDB) ------- Piperidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 951 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Piperidine 4890 110894 Attribute Scores 3-model Categorical Prediction Potency Severity 7 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 22.4 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1975 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 5 5 Li~L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New ndustrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue);page/year 14,90,1975 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N M8/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Piperidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 952 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; rubber accelerator (HSDB) Value 0.84 4.35E-06 1,000,000 45 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- p-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 953 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Nitrosodiphenylamine 6319 156105 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 1 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL-NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.022 B2 3 mg/L (mg/kg-d)"1 (mg/kg-d)-' (mg/kg-d)"1 1987 Cited by OEHHA Vol. 27, Suppl. 7 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1.59 Y/N Y/N W/L W/L CACART; OEHHA; EPA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentrat on at the 1 0 "6 cancer risk was used. ------- p-Nitrosodiphenylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 954 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release -total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; food additve; rubber accelerator (HSDB) Value 38 days 3.16 1.10E-08 17.3 16 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- p-Nitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 955 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Nitrotoluene 4071 99990 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 55 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect splenic lesions Blood - leukemia, Tumorigenic - active as anti-cancer agent Prevalence Magnitude 65 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; NTP 1992; Bass LOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 105-week oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year NIHNo.01-4432 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.017 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1996 Vol. 65 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2.06 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- p-Nitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 956 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life K0c« Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for dyes (HSDB) Value 309 2.37 5.63E-06 442 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Poly(dimethyl diallyl ammonium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 957 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Polyfdimethyl diallyl ammonium chloride) 29130 26062793 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 290 1,720 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1988 Critical Effect Liver - other, blood - changes in spleen Behavioral - somnolence (general depressed activity), Behavioral - convulsions or effect on seizure threshold, Lungs, Thorax, or Respiration - respiratory depression Prevalence Magnitude ,,, _ 7 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; QISAAA Qigiena i Sanitariya. For English translation, see HYSAAV. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 53(3),66,1 988 Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 53(3), 66,1988 Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 678 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Poly(dimethyl diallyl ammonium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 958 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes PPCPs (NLM/NIH) Value 1 5 days 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Potassium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 959 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Potassium 18836 7440097 Attribute Scores 3-model Categorical Prediction Potency Severity 4 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 67 0.94 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect No effect Cardiac - changes in heart weight, Gastrointestinal - other changes, Blood - changes in cell count (unspecified) Prevalence Magnitude ,,, „ 10 10 NL' HRL Ratio(s) NCHRL/NIRS90%: 0.08 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; DRI pg.235; NAS Lowest Observed Adverse Effect Level; 180-day oral study in rat; VCVN1 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 469 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Potassium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 960 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 958 96.9 311 23,955 1,860 5,939 15,422 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites/ Samples 10,193 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 9,307 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 91.3 Minimum value of Detects Units States States States Minimum value of Detects 60 Non-cancer: 0.08 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 3,900,000 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 2,790 90% of Detects 5,000 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Laboratory reagent (HSDB) Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- p-Phenetidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 961 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): p-Phenetidine 6322 156434 Attribute Scores 3-model Categorical Prediction Potency Severity 7 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 0.242 530 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1978 1981 Critical Effect Bone marrow toxicity, methemaglobinemia, spleen toxicity Blood - normocytic anemia, Blood - methemoglobinemia-carboxyhemoglobin, Blood - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 58 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 9-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (WO Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/pagefyear 43(1 ),92, 1978; LOAEL was used forpotency scoring because it was lower than the NO(A)EL from other studies. Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Vo ume(issue)/page/year 25(8), 50,1981 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.56 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- p-Phenetidine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 962 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M XIM-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate (Merck Index, 1983; OECD SIDS) Value 1.24 1.50E-07 7,510 45 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrqades sometimes/recalcitrant (BIODEO) ------- Prometon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 963 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Prometon 11873 1610180 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.015 0.015 0.015 15 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1886 1986 2001 Critical Effect No treatment related effects observed. Decreased Potency Score by one integer Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude ,,, 1 1 NL HRL Ratio(s) NC HRL/NAWQA AW 90% : 1 ,438 Notes Reference Dose Reference Dose; Ciba-Geigy, 1982a; Basis NOAEL 15 mg/kg-d, rat, UF=1000. IRIS also reports maternal toxicity in a study not used for the RfD derivation; Severity scored on this critical effect. Reference Dose; Ciba-Geigy, 1982a; Basis NOAEL 15, rat, UF=1000 Reference Dose; Ciba-Geigy, 1982a; Basis NOAEL 15, rat, UF=1000 Minimal Risk Leve Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 2,1512,2001 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.5 105 Y/N Y/N W/L W/L 1988 Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Rela ive Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Prometon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 964 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS POP POP PPMP HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T1/2, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,128 # Sam pies Amount Released # PWSs/Sites/ Samples 609 288 553 1,627 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 26 145 22.8 % Samples with detects 2.92 0.49 Number of States % PWSs/Sites/ Sam pies with detects 0 4.7 63.6 0.0004 Minimum value of Detects Units States States States Minimum value of Detects Not Detected 0.0025 Non-cancer: 1,438 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 40 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected 0.0025 0.103 0.014 Median value of Detects 0.15 0.16 0.073 90% of Detects 0.381 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan te.aspx Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001 (GC/MS) Herbicide (HSDB) Value 60 days 156 2.99 3.18E-09 750 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Propanenitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 965 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propanenitrile 4591 107120 Attribute Scores 3-model Categorical Prediction Potency Severity 5 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20 35.8 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1996 Critical Effect Maternal toxicity and slight fetotoxicity Prevalence Magnitude , „ 67 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; Journal -Johansen etal, 1986 Lowest Observed Adverse Effect Level Supplemental Data Lewis, R.J., Dangerous Properties of Industrial Materials, 9th Ed., Vol. 1-3, NY, NY, Van Nostrand Reingold, 1996., p 2799 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Propanenitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 966 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; industrial solvent (HSDB) Value 1 5 days 29 0.16 3.70E-05 130,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Propargite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 967 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propargite 13082 2312358 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.04 0.02 0.02 0.01 1,480 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1999 1969 Critical Effect Decreased body weight & body weight gain, increased mortality. Q1* 0.0033 (mg/kg-day)-1 . See CAR Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 64 L' HRL Ratio(s) NC HRL/NAWQA AW 90% : 477 Notes Reference Dose Reference Dose; Uniroyal Chemical, 1966, 1982; Basis NOEL 22.5 mg/kg-d, dog, UF=1000 Reference Dose Reference Dose; Uniroyal Chemical, 1966; Basis NOEL, dog, UF=1000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 14,515,1969 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.0033 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 OPP Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 280 Y/N Y/N W/L W/L Developmental CACART CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Propargite CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 968 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,108 # Sam pies Amount Released 2,538,969 0 253 # PWSs/Sites/ Samples 288 688 62 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 0.872 % Samples with detects Number of States 30 0 1 % PWSs/Sites/ Samples with detects 0 0.0026 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: 477 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 20 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected 0.044 Median value of Detects 0.587 90% of Detects 3.5 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L ug/L ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001(GC/MS) Cancer: nsecticide (HSDB) Value 60 days 138,000 5 4.16E-08 0.5 8 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Propargyl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 969 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propargyl alcoho 4597 107197 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.002 0.002 20 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 1982 Critical Effect Increased liver & kidney weights, megalocytosis of the iver iver, kidney Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 66 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S.EPA, 1987; Basis NOAEL 5 mg/kg-d, rat, UF=3000 Reference Dose Reference Dose; U.S.EPA, 1987; Basis NOAEL/LOAEL, rat, UF=3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vo . 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/vear 2C, 4672, 1982 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 14 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Propargyl alcohol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 970 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 64,096 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 6 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Corrosion inhibitors; in pharmaceutcals; chemical intermediate (HSDB) Value 1.325 -0.38 1.15E-06 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF/BST Notes BF = Biodegrades fast; BST = Biodegrades sometimes/reca citrant (BIODEG) ------- Propionaldehyde CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 971 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propionaldehyde 5508 123386 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1971 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 8 L HRL Ratio(s) NC HRL/DBP ICR MED: 8.2 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data KODAK Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year 21MAY19T1 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 56 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Propionaldehyde CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 972 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBF ICR # PWSs/Sites sampled 236 #with Detects 4 % PWSs/Sites with detects 1.69 Mean value of Detects 7.2 Maximum value of Detects 9.9 Median value of Detects 6.8 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/DBP ICR MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 9,607 699,803 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 4 15 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 8.2 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; chemical intermediate (HSDB) Value 15 days 50 0.59 7.30E-05 306,000 48 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slowly ------- Propionic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 973 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propionic acid 2861 79094 Attribute Scores Potency Severity 3 6 Prevalence Magnitude 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 735 1,640 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect hyperplasia of the esophagus; nitrite in urine Details of toxic effects not reported other than lethal dose value 3-model Categorical Prediction NL? - L? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; OPP RED Lowest Observed Adverse Effect Level Supplemental Data Rat; GISAAA G giena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 39(4), 86,1974 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5,145 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Propionic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 974 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 100M-500M 100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Pesticide; food additive; chemica intermediate (HSDB) Value up to 21 days 36 0.33 1,000,000 sr Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (HSDB) ------- Propoxyphene hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 975 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propoxyphene hydrochloride 11929 1639607 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 207 82 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1971 1971 Critical Effect Liver - changes in liver weight, Blood - changes in erythrocyte (RBC) count, Nutritiona and Gross Metabolic - weight loss or decreased weight gain Behavioral - somnolence (general depressed activity), Lungs, Thorax, or Respiration - respiratory depression Prevalence Magnitude ,,, 1 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 19,452,1971 Supplemental Data Rabbit; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 19,445,1971 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 483 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Propoxyphene hydrochloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 976 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K Units Ibs/yr Ibs/yr Year 1990 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes d-isomer as veterinary medicine (HSDB - CASRN 469-62-5) Value 38 days 4.18 12 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) Kow for d-propoxyphene ------- Propylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 977 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propylene glycol 2323 57556 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 5 Units mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect hematological changes Blood - normocytic anemia, Blood - other hemolysis with or without anemia Prevalence Magnitude 10 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Bauer et al; Basis LOAEL, cat, UF = 3000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in dog; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organ cheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. etal., Chimia, 1994 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 3,500 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Propylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 978 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food additive; in PPCPs; as coolant (HSDB) Value 1 -0.92 1.31E-10 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Propylene glycol 1-methyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 979 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propylene glycol 1 -methyl ether 4655 107982 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.7 5,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1972 Critical Effect Histo pathology Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 88 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; USEPA, 1 991 ; Basis NOEL = 1 mg/kg-d, rat, UF = 1 000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Dog; ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(ssue)/page/year 22,569,1972 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 4,900 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Propylene glycol 1-methyl ether CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 980 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n paints and coatings; pesticide so vent (HSDB) Value 1 5 days 1 -0.49 9.20E-07 1,000,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Propylene glycol monomethyl eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 981 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propylene glyco monomethyl ether acetate 4706 108656 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 300 8,532 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased body weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 7 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data DOWCC Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, Ml 48640) Vo ume(issue)/page/year MSD-1582 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,100 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Propylene glycol monomethyl eth CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 982 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units Cancer: Notes Pesticide inert (EPA OPP) Value 15 0.56 3.44E-06 198,000 45 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Propylene glycol mono-t-butyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 983 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Propylene glyco mono-t-butyl ether 37358 57018527 Attribute Scores Potency Severity Prevalence Magnitude 5 8 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Equivocal evidence of carcinogenicity n male rats; clear evidence in male/female mice (NTP) Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Propylene glycol mono-t-butyl CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 984 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; in PPCPs; in paints and coatings (HSDB) Value 5 0.87 4.73E-06 173,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST= biodegrades sometimes / reca citrant (HSDB) ------- Pyrazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 985 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pyrazon 12037 1698608 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.18 66 493 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1992 1992 Critical Effect Decreased body weight & body weight gain Liver - changes in liver weight, Endocrine - changes in thyroid weight, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 7 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in rat; NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Vo ume(issue)/page/year 17,3171,1992 Supplemental Data Guinea pig; NNGADV Nippon Noyaku Gakkaish . Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year 1 7,S1 71 ,1 992 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,260 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Pyrazon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 986 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 118,294 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 9 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (HSDB) Value 38 days 33-346 1.14 6.50E-12 400 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrdaes slow with acclimation (PBT) ------- Pyridine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 987 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pyridine 4887 110861 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.001 0.255 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1958 Critical Effect ncreased liver weight Blood - change in clotting factors, Related to Chronic Data - death Prevalence Magnitude 99 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose; U.S.EPA, 1986; Basis NOAEL = 1 mg*g-d, rat, UF = 1000 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 14-week oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 23(7), 30,1 958 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7 Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pyridine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 988 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 526 1,302,842 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 6 21 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent; chemica intermediate; food additive; unreg stered pesticide (HSDB) Value 33 0.65 1.10E-05 1,000,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA/BST Notes BFA = Biodegrades fast with acclimat on/BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- Pyridine, pentachloro- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 989 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Pyridine, pentachloro- 12850 2176627 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 435 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Sense Organs and Special Senses (Eye) - lacrimation, Behavioral -somno ence (general depressed activity), Behavioral -convulsions or effect on seizure threshold Prevalence Magnitude 67 Li HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume issue)/page/year OTS0536503, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Pyridine, pentachloro- CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 990 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemica Value 1 80 days 2,000 3.53 6.30E-03 16 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- Quartz (SiO2) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 991 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Quartz (Si02) 24322 14808607 Attribute Scores 3-model Categorical Prediction Potency Severity 1 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 120,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Gastrointestinal - hypermotility, diarrhea, Gastrointestinal - other changes Prevalence Magnitude 1 Incomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect LevelEPASR United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Vo ume(issue)/page/year#86940001000,1994. Rodent - rat. Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10^ RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 1 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 280,000 Y/N Y/N W/L W/L IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Quartz (SiO2) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 992 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10K-50K >10K-50K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Naturally-occurring mineral Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- Quizalofop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 993 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Quizalofop 76725 76578126 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Prevalence Magnitude 10 8 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Quizalofop CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 994 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 340,818 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 35 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Derivative of the herbicide quizalofop-ethyl (HSDB) Value 38 days 3.57 0.3 12 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Santoflex 13 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 995 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Santoflex 13 9730 793248 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6 62.3 3,580 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Liver cell enlargement or alteration Liver - changes in liver weight, Blood - normocytic anemia, Blood - changes in leukocyte (WBC) count Sense Organs and Special Senses (Eye) - effect, not otherwise specified, Behavioral - food intake (animal), Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude ,,, _ 7 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0545431 Supplemental Data rodent-rat; ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year 1,67,1990 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 42 Y/N Y/N M8/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Santoflex 13 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 996 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Antioxidant/antiozonant (HSDB) Value 38 days 11 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Sethoxydim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 997 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sethoxydim 65122 74051802 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.14 0.09 0.09 3,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Liver effects: hepatocellular hypertrophy & fatty degeneration Mild anemia in males Mild anemia in males Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 10 7 L HRL Ratio(s) No water data Notes Reference Dose, BASF Corporation, 1984 Reference Dose, BASF Corporal on, 1984, NOEL = 9.41 mg/kg-d, dog, UF = 100 Reference Dose Reference Dose, BASF Corp., 1984, NOEL/LEL, dog, UF=100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year-,C274,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 980 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sethoxydim CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 998 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 1,717,271 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 48 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Herbicide (HSDB) Value 38 days 2,845 4.38 2.16E-11 25 11 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Silicon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 999 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Silicon 18845 7440213 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3,160 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 10 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No. ?-57, 1948-77. Discontinued. Volume(issueypage/year53A,21,1974, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Silicon CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1000 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 989 100 0.26 98.9 18.1 42.1 67.5 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L mg/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; alloys (HSDB) Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- Sodium CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1001 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium 18847 7440235 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 9.38 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Cardiac - changes in heart weight, Gastrointestinal - other changes, Blood - changes in cell count unspecified) Prevalence Magnitude , „ 10 10 L HRL Ratio(s) NCHRL/NIRS90%:0.14 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, VCVN1 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia e ementov I-IV groopp" (Hazardous substances. Inornanic substances containing l-IVgroup elements), Filov V.A., Chimia, 1988. Volume(issue)/page/year - ,36,1988 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 CADW EPA HA Health Reference Level (HRL)2 cancer 21.9 200 20 Y/N Y/N M8/L mg/L mg/L M8/L F'03 Drinking Water Equivalent Level Aesthetic Objective (AO) Health Advisory Status For individuals on a SOOmg.day restiricted sodium diet 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1002 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 989 100 0.907 1,541 16.4 160 498 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total CAL DHS HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites/ Samples 11,845 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 11,826 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 99.8 Minimum value of Detects Units States States States Minimum value of Detects 7 Non-cancer: 0.14 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects 173,000,000 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L mg/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 90% of Detects Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Chemical intermed ate; alloys; sem conductors (HSDB) Value 14.3 -0.77 0.0246 445,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegrades sometimes/recalcitrant ------- Sodium azide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1003 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium azide 29534 26628228 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.004 0.004 5 0.25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1999 Critical Effect Clinical signs (e.g., hunched postures) & reduced body weight Clinical signs & reduced body weight Cardiac - EKG changes not diagnostic of specified effects, Liver - liver function tests impaired, Kidney, Ureter, Bladder - other changes in urine composition Prevalence Magnitude 3 6 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose; NCI, 1981; Basis NOEL = 5 mg/kg-d, rat, UF = 1,000 Reference Dose Reference Dose; NCI, 1981; Bas s NOAEL/LOAEL, rat, UF=1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 26-week oral study in unspecified mammal; STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, zd AT 1 999 Volume(issue)/page/year -, 1 73, 1 999 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 28 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium azide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1004 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 66,425 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 3 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; herbicide (HSDB) Value 1.342 0.16 7.78E-05 36,700 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Sodium benzoate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1005 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium benzoate 7550 532321 Attribute Scores 3-model Categorical Prediction Potency Severity 3 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,505 2,090 1,600 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 1993 1986 Critical Effect Behavioral - convulsions or effect on seizure threshold, Nutritional and Gross Metabolic - weight loss or decreased weight gain, Related to Chronic Data - death Increased liver and kidney weight, increased serum albumin and total protein, increased GGT, enlarged hepatocytes with glassy cytoplasm Behavioral - changes in motor activity (specific assay), Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude ,,, „ 7 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 13-week oral study in rat; TRENAF Kenkyu Nenpo-Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo- toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year42,285,1991 Supplemental Data, Fujitani, 1993 rodent-mouse; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 51(1), 75,1986 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 14,630 Y/N Y/N M8/L W/L Teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium benzoate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1006 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food and pharmaceutical preservative; medication (HSDB) Value 1 5 days 556,000 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Sodium bromide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1007 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium bromide 19109 7647156 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.129 3,500 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1972 1935 Critical Effect Liver -changes in liver weight, Biochemical -Enzyme inhibition, induction, or change in blood or tissue evels - transaminases Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 5 10 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Qigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 37(1), 13,1972, rodent-rabbit Supplemental Data rat study; JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 55,200,1935 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.3 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium bromide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1008 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1990 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Photographic chemical; in chemica synthesis (HSDB) Value 909,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Sodium chlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1009 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium chlorate 19266 7775099 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.03 1.36 1,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 2001 Critical Effect Thyroid hypertrophy Blood - pigmented or nucleated red blood cells, Blood - changes in erythrocyte (RBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 9 8 L HRL Ratio(s) NC HRL/SWC EEC: 304 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 1-year oral study in rat; JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbtal, POB134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year 6(1), 105,1 985 Supplemental Data rodent-rat; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year2,1412,2001 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 210 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium chlorate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1010 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 7,261 ,557 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 16 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 Surface water chronic: 0.69 ug/L Non-cancer: 304 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: Cancer: Herbicide; oxidizing agent in PPCPs and industrial processes (HSDB) Value 75,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Sodium chloroacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1011 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium chloroacetate 15383 3926623 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 60 95 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 1941 Critical Effect Liver - changes in liver weight, Kidney, Ureter, Bladder changes in bladder weight, Blood - changes in eukocyte (WBC) count Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 6 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 90-day oral study in rat; TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year 67,171,1991 Supplemental Data rodent-rat; JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V. 18-31, 1936-49. For publisher information, see AEHLAU. Volume(ssue)/page/year 23,78,1941 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Sodium chloroacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1012 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemica Value 1 5 days 41 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Sodium dimethyldithiocarbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1013 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium dimethyldithiocarbamate 5680 128041 Attribute Scores 3-model Categorical Prediction Potency Severity 4 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 114 300 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1976 2000 Critical Effect Developmental toxicity Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 77 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplimental Data, Toxicology and Applied Pharmacology VolumeSS, Issue 1, January 1976, Pages 83-94 rodent- rabbit; TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year (3), 34,2000 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 266 Y/N Y/N W/L W/L developmental CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Sodium dimethyldithiocarbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1014 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 31,009 129,318 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 3 9 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial antimicrobial (HSDB) Value 0.01 3-1. 08 days 2.2 1,000,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Sodium dodecylbenzenesulfonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1015 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium dodecylbenzenesulfonate 28421 25155300 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 101 438 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1975 1972 Critical Effect Liver - other changes, Blood - changes in serum composition (e.g. TP, bilirubin, cho esterol), Nutritiona and Gross Metabolic - changes in iron Sense Organs and Special Senses (Eye) - lacrimation, Behavioral - somno ence (general depressed activity), Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude 7 5 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issueypage/year 3,1 15,1 975 Supplemental Data rodent- rat; TRENAF Kenkyu Nenpo-Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1 , 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year 24,397,1972 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 236 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium dodecylbenzenesulfonate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1016 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Detergent; in pesticide formulations (HSDB) Value 1 5 days 111 0.45 6.27E-08 800,000 21 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Sodium fluoroacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1017 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium fluoroacetate 2445 62748 Attribute Scores 3-model Categorical Prediction Potency Severity 8 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00002 0.00002 0.00002 0.0216 0.066 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1960 1951 Critical Effect Histopathology & decreased size & weight of testes and epididymides ncr. heart weight; reproductive effects in male increased heart wt, decreased testiswt, altered spermatogenesis Related to Chronic Data - death Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 1 1 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose, U.S. EPA, 1988, Basis NOAEL = 0.05 mg/kg-d, rat, UF = 3,000 Reference Dose Reference Dose; USEPA, 1988, oral study in rats, UF = 3,000, Basis NOAEL/LOAEL Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 30-day study in domestic mammal; JCPTA9 Journal of Comparative Pathology and Therapeutics. (Liverpool, UK) V.1-74, 1883-1964. For publisher information, see JCVPAR. Volume(issue)/page/year 70,145,1960 Supplemental Data mammal- dog; JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year 101,82,1951 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.14 Y/N Y/N W/L W/L Male reproductive CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium fluoroacetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1018 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 0 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 0 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2002 2002 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Rodenticide (HSDB) Value 1.201 -3.78 1.09E-06 111,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (HSDB) ------- Sodium hypochlorite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1019 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium hypochlorite 19138 7681529 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 Scores based on parent HEALTH EFFECTS DATA1 See parent Sodium Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 9.38 5,800 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1986 Critical Effect Cardiac - changes in heart weight, Gastrointestinal - other changes, Blood - changes in cell count (unspecified) (for parent sodium) Behavioral - changes in motor activity (specific assay), Gastrointestinal - other changes Prevalence Magnitude , „ 10 10 L Scores based on parent HRL Ratio(s) NC HRL/NIRS 90%: 0.14 (HRL and NIRS based on parent Sodium) Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, VCVN1 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), FilovV.A., Chimia, 1988. Volume(issueypage/year- ,36,1 988; 9 week study in rats. Supplemental Data rodent- mouse; SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year27,553,1986 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21.9 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on parent Sodium 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium hypochlorite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1020 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 989 100 0.907 1,541 16.4 160 498 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NIRS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 0.14 Amount Range >1M-10M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L mg/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes For parent sodium National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Bleach; disinfectant; medication (HSDB) Value 293,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Sodium methyldithiocarbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1021 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium methyldithiocarbamate 5951 137428 Attribute Scores 3-model Categorical Prediction Potency Severity 5 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 20.2 50 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 1965 Critical Effect Blood - normocytic anemia, Blood - pigmented or nucleated red blood cells, Blood - leukopenia Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ , 9 10 L"L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issueXpage/year 32(2),1 1 ,1967; 30 week rabbit study Supplemental Data rodent- mouse; RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year 10,97,1965 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 47.1 Y/N Y/N W/L W/L Developmental CACART CACART Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium methyldithiocarbamate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1022 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 60,023,092 40 10,500 OPP Estimated Environmental Concentration HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 20 1 2 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Surface water chronic: 0 ug/L Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic: 0 ug/L Cancer: Soil fumigant (HSDB) Value -2.62 722,000 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (HSDB) ------- Sodium sulfide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1023 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium sulfide 11113 1313822 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 205 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 10 HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1 -36, 1957-1992. For publisher information, see MTPEEI Volume(issue);page/year 30(8),30,1 986, rodent-mouse Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Sodium sulfide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1024 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Metal precipitation; chemical reagent; medication (HSDB) Value 186,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (HSDB) ------- Sodium vanadate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1025 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sodium vanadate 23292 13718268 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.616 74.6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1984 Critical Effect Kidney- Impaired function Gastrointestinal - ma absorption, Kidney, Ureter, Bladder - changes in bladder weight, Nutritional and Gross Metabolic - changes n calcium Behavioral - ataxia, Lungs, Thorax, or Respiration - dyspnea, Gastrointestinal - hypermotility, diarrhea Prevalence Magnitude 5 ncomplete data for scoring HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA, 1987, NOAEL, rat, UF=1,000 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 6-week oral study in rat; BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year 37,899,1986 Supplemental Data rodent- mouse; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(ssue)/page/year 23,227,1984 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sodium vanadate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1026 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1986 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial chemica Value Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Sorbitol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1027 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sorbitol 2145 50704 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 833 1,167 15,900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1999 1974 Critical Effect Gastrointestinal - other changes Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 7 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data; Maximum Recommended Da ly Dose (MRDD) No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, FGTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year 37,233,1999, mammal- human study Supplemental Data FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year 53A, 498,1 974 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2,723 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Sorbitol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1028 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Food and pharmaceutical additive (HSDB) Value 2 -2.2 7.30E-13 2,200,000 27 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (HSDB) ------- Spinosyn A CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1029 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Spinosyn A 70751 131929607 Attribute Scores Potency Severity 5 6 Prevalence Magnitude 9 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2001 Critical Effect Vacuolation of the thyroid gland epithelial cells, inflammation in the thyroid, lung, and larynx; bone- marrow hyperplasia and dilatation of liver sinusoids 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/SWC EEC: 1,522 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake, Acute RfD unnecessary Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Spinosyn A CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1030 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data # Sam pies Amount Released 117,315 OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 21 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 Surface water chronic: 0.092 ug/L Non-cancer: 1,522 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Notes Ground water chronic Cancer: nsecticide (HSDB) Value 2.8 89.4 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Stearic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1031 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Stearic acid 2305 57114 Attribute Scores 3-model Categorical Prediction Potency Severity 3 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1,490 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 Critical Effect Related to Chronic Data - death Prevalence Magnitude .,, „ 8 3 NL!'L! HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-15, 1982-1996. Discontinued. Volume(issue)/page/year 14,196,1995, 30 week rodent-rat study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3,478 Y/N Y/N M8/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Stearic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1032 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >500M-1B >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; food and pharmaceutical additive (HSDB) Value 720,000 8.23 4.80E-07 0.568 4 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Sulfurous acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1033 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sulfurous acid 19341 7782992 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1906 Critical Effect Gastrointestinal - hypermotility, diarrhea, Gastrointestinal - nausea or vomiting, Gastrointestinal • other changes Prevalence Magnitude 5 HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level, AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year 54,421,1906, human study Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.17 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Sulfurous acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1034 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1994 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Reaction product of SO2 and H2O Value Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Sulfuryl fluoride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1035 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sulfuryl fluoride 13814 2699798 Attribute Scores Potency Severity 6 6 Prevalence Magnitude 2 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.003 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 Critical Effect Vacuolization of the white matter in the brain in female rabbits 3-model Categorical Prediction NL7-L? HRL Ratio(s) No water data Notes Reference Dose, 1/006 Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Zenz, C. Occupational Medicine- Principles and Practical Applications. 2nd ed. St. Louis, MO: Mosby- Yearbook, Inc, 1988., p. 684, rat and guinea pig study Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 21 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sulfuryl fluoride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1036 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 142,720 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 2 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes nsecticide/fumigant; chemical intermediate (HSDB) Value 750 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Sulprofos CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1037 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Sulprofos 32748 35400432 Attribute Scores 3-model Categorical Prediction Potency Severity 6 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.6 65 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1977 Critical Effect Blood - normocytic anemia, Blood - changes in serum composition (e.g. TP, bilirubin, cho esterol), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 7 6 L HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Otawerved Adverse Effect Level, NNQADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year 12,775,1987, 13 week rodent- rat study Supplemental Data rodent- rat; 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year 1,205,1977 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1.4 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Sulprofos CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1038 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 308,039 # PWSs/Sites/ Samples 283 669 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 8 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 9002(GC/MS) Cancer: Cancelled insecticide (HSDB) Value 38 12,000-13,500 5.48 8.60E-07 0.31 7 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Tartrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1039 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tartrazine 12444 1934210 Attribute Scores 3-model Categorical Prediction Potency Severity 3 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 773 7.5 12,750 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2006 1966 Critical Effect Neurobehavioral effects Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 5 8 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data, Tanaka Food chem Toxicol 44:179-87 2006 Supplemental Data; Maximum Recommended Da ly Dose (MRDD) rodent- mouse; FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year 386,88,1966 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 1,804 Y/N Y/N W/L W/L teratogen list UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tartrazine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1040 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M n sanitizing solut Value 300,000 50 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ons (food industry); in dyes (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (HSDB) ------- Tebuthiuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1041 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tebuthiuron 32336 34014181 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.07 0.07 0.07 0.07 7 96 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1992 Critical Effect Reduced body weight gain in F1 females Depressed body wieght gain in F1 males Depressed body weight gain in females Gastrointestinal - changes in structure or function of endocrine pancreas, Kidney, Ureter, Bladder - changes in bladder weight Prevalence Magnitude .,, .,, „ 10 3 NL'NLi HRL Ratio(s) NC HRL/NAWQA AW 90% : 7,424 Notes Reference Dose Reference Dose, Elanco Products, 1981, Basis NOEL = 7 mg/kg-d, rat, UF = 100 Reference Dose Reference Dose, Elanco Products, 1981, NOEL/LEL, rat, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Vo ume(issue)/page/year 17,335,1992 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification D mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2 490 Y/N Y/N mg/L W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tebuthiuron CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1042 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP POP PPMP PPMP CAL DHS HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,097 # Sam pies Amount Released 115,712 0 5 # PWSs/Sites/ Samples 154 336 # PWSs/Sites/ Samples 66 799 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3 19 64 42 #with Detects 11.26 % Samples with detects Number of States 2 0 1 % PWSs/Sites/ Sam pies with detects 1.9 5.7 28.1 18.7 % PWSs/Sites/ Sam pies with detects 0 0.001 Minimum value of Detects Units States States States Minimum value of Detects 16.3 1 Minimum value of Detects Non-cancer: 7,424 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 17.3 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 16.3 14 0.032 0.077 Maximum value of Detects 0.013 Median value of Detects 0.066 90% of Detects 0.546 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Median value of Detects 95% of Detects 0.019 0.077 90% of Detects Units for Mag data ng/L ng/L ug/L ug/L Units for Mag data ug/L Notes Pesticide Data Program (USDA) 2001 Pesticide Data Program (USDA) 2002 Pesticide Pilot Monitoring Program (USGS/EPA) 2001(GC/MS) Pesticide Pilot Monitoring Program (USGS/EPA) 9060(HPLC/MS) Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Cancer: Herbicide (HSDB) Value 38 22.8 1.79 1.20E-10 2,500 27 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Terbufos-O-analogue sulfone CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1043 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Terbufos-O-analogue sulfone 76778 56070156 Attribute Scores 3-model Categorical Prediction Potency Severity 7 3 Scores based on parent Prevalence Magnitude ,,, 1 1 NL Scores based on parent HRL Ratio(s) HEALTH EFFECTS DATA1 See Terbufos and Terbufos sulfone Parent Terbufos and Terbufos sulfone on CCL for parent terbufos) Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Plasma ChE inhibition Notes Reference Dose - FOR PARENT TERBUFOS Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.35 Y/N Y/N ug/L M/L Drinking Water Equivalent Level Based on data for parent terbufos 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Re ative Source Contribut on of 20%. For carcinogens, the concentration at the 10 "B cancer risk was used. ------- Terbufos-O-analogue sulfone CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1044 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Finished Water Occurrence Data FOR TERBUFOS - PARENT UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 300 0 0 Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Not Detected Not Detected Not Detected Not Detected Not Detected Ambient Water Occurrence Data FOR TERBUFOS - PARENT N AWQA ambient water MREC ambient surface water MREC ambient ground water MREC ambient surface water MREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data PPMP finished water PPMP ambient water HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters r,72, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 # Samples Amount Released # PWSs/Sites/ Samples 22 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2 0 0.31 % Sam pies with detects Number of States % PWSs/Sites/ Samples with detects 0.9 0 0.0021 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 1.67 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 0.56 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.016 0.017 Median value of Detects 0.21 90% of Detects 0.56 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Notes Pesticide Pilot Mentoring Program (USGS/EPA) Pesticide Pilot Mentoring Program (USGS/EPA) Cancer: NAWQA data and HRL for Parent Terbufos Analogue and degradate of the pesticide terbufos Value 38 days 14 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA= Biodegrades slow with acclimaton (PBT) ------- Terephthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1045 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Terephthalic acid 4091 100210 Attribute Scores 3-model Categorical Prediction Potency Severity 3 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHERfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1 143 3,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1971 Critical Effect Bladder- Hyperplasia Brain and Coverings - changes in brain weight, Cardiac - changes in heart weight, Kidney, Ureter, Bladder - changes in bladder weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 10 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose, U.S. EPA, 1986, NOEL, rat, UF = 100 Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; 2-year oral study in rat; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/yearOTS0543783 Supplemental Data rodent- mouse; KODAK Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year 21 MAY1 971 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7,000 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Terephthalic acid CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1046 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1H, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in poultry feeds (HSDB) Value 71.6 2 3.89E-13 15 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- tert-Butanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1047 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): tert-Butanol 2670 75650 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 90 107 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1995 Critical Effect Decreased body weight males; increased relative and absolute and relative kidney weights Cancer some evidence in male rats and female mice, equivocal evidence in male mice and no evidence in female rat Liver - other changes, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , „ 10 9 L HRL Ratio(s) NCHRL/CALDHS90%:21.1 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, NTP TR436 Lowest Observed Adverse Effect Level; 10-week oral study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 80,97,1995 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 630 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- tert-Butanol CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1048 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/CAL DHS 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 12,324 1,548,617 # PWSs/Sites/ Samples 7,600 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 86 % Samples with detects Number of States 7 31 % PWSs/Sites/ Samples with detects 1.13 Minimum value of Detects Units States States States Minimum value of Detects 2 Non-cancer: 21.1 Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 93 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 3.95 90% of Detects 29.9 Units for Mag data ug/L Cancer: Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Former pesticide; gasoline additive; in PPCPs (HSDB) Value 37 0.35 9.05E-06 1,000,000 44 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS/BST Notes BS = Biodegrades slow (BIODEG); BST = Biodegrades sometimes/recalcitrant (BIODEG) ------- tert-Butyl hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1049 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): tert-Butyl hydroperoxide 2693 75912 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 320 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1979 Critical Effect Behavioral - irritability, Gastrointestinal - alteration in gastric secretion, Blood - hemorrhage Prevalence Magnitude , „ 67 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New ndustrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year 15,90,1979, rodent-mouse Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- tert-Butyl hydroperoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1050 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; chemical intermediate (HSDB) Value 1 5 days 97 0.94 1.60E-05 42 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- tert-Butylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1051 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): tert-Butylamine 2669 75649 Attribute Scores 3-model Categorical Prediction Potency Severity 6 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 44 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral - food intake (animal), Lungs, Thorax, or Respiration - pulmonary emboli, Liver - other changes Prevalence Magnitude , „ 67 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0534846, rodent-rat Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- tert-Butylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1052 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Chemical intermed ate for rubber accelerators, insect Value 1 5 days 40 0.4 1,000,000 47 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Maximum value of Detects Year 1997 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes cides, fungicides, dyestuffs, Pharmaceuticals and oil additives (HSDB) Notes BS = Biodegrades s ow (PBT) ------- tert-Butyl benzene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1053 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): tert-Butylbenzene 3932 98066 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 4.42 3,045 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1990 Critical Effect Behavioral -alteration of classical conditioning Prevalence Magnitude ,,, „ 3 6 NL' HRL Ratio(s) NC HRL/NCOD R1 90%: 1.03 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; VCVGH "Vredniechemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances Galogenated hydrocarbons) Sandman A. L. etal.,Chimia, 1990. Volume(issue)/page/year -,179, 1990; 24 week oral study in rats Supplemental Data rat study Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 10.3 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- tert-Butyl benzene CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1054 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 12,353 22,973 24 25 0.19 0.11 0.02 0.10 10 77.5 0.8 0.5 10 5 10 77.5 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (HRL/NCOD R1 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 4,309 # Sam pies Amount Released # PWSs/Sites/ Samples 11,885 10 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 2 0.232 % Samples with detects Number of States % PWSs/Sites/ Samples with detects 0.02 0.009 Minimum value of Detects Units States States States Minimum value of Detects 0.62 Non-cancer: 1.03 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.1 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.9 0.06 Median value of Detects 0.11 90% of Detects 1.1 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 0.76 90% of Detects 0.872 Units for Mag data ug/L Cancer: Notes Solvent; in organ c synthesis (HSDB) Value 38 days 1,181 4.11 0.0132 29.5 14 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Tetraethyl lead CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1055 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetraethyl lead 2781 78002 Attribute Scores 3-model Categorical Prediction Potency Severity 10 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0000001 0.06 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 1983 Critical Effect Histopathology of liver & thym us Endocrine - other changes Prevalence Magnitude 5 7 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose; Basis = LOAEL 0.0012 mg/kg-day, rat, UF = 10,000 (Schepers, 1364) Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat 6W-C; JANSY Journal of the autonomic nervous system (Amsterdam, Elsevier/North Holland Biomedical Press) V.1-81 1979-2000. Volume(issue)/page/year8,287,1983 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.0007 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tetraethyl lead CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1056 of 1124 OCCURRENCE DATA1 Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former anti-knock agent in gasol ne; chemical intermediate (HSDB) Value 758 4.15 0.568 0.29 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DS Notes DS = Degrades slow (HSDB) ------- Tetrafluoroethene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1057 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetrafluoroethene 5138 116143 Attribute Scores Potency Severity Prevalence Magnitude 7 7 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1999 Vol. 19, Suppl 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L CACART; IARC; Clear evidence of carcinogenicity in male and female rats and mice (NTP). Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tetrafluoroethene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1058 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Polymer intermec Value 110 0.63 159 44 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate; in propellants (HSDB); gas Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (HSDB) ------- Tetrahydrofuran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1059 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetrahydrofuran 4813 109999 Attribute Scores 3-model Categorical Prediction Potency Severity 3 7 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.01 481 38.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2000 1967 Critical Effect Systemic parental and developmental toxicity. Blood - change in clotting factors, Blood - changes in eukocyte (WBC) count, Nutritional and Gross Metabolic - weight loss or decreased weight gain Prevalence Magnitude , „ 96 L HRL Ratio(s) NC HRL/NAWQA AW 90% : 375 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake; Oral study Supplemental Data No Observed Effect Level Supplemental Data; (Hellwig, et al. Food and Chemical Toxicology 40 (2002) 1515-1523) Lowest Observed Adverse Effect Level; oral study in rat 17W-I; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 32(2), 99,1 967 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 3,366 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tetrahydrofuran CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1060 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA AW 90% ) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 2,601 # Sam pies Amount Released # PWSs/Sites sampled 93 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 3.58 % Samples with detects Number of States % PWSs/Sites with detects 0.07 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 375 Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 1,430 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.75 Median value of Detects 8.98 90% of Detects 1,146 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Solvent (HSDB) Value 15 days 18-23 0.46 7.10E-05 1,000,000 48 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Tetramethylammonium chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1061 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetramethylammonium chloride 2662 75570 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 50 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Behavioral -somnoence (general depressed activity), Behavioral - convulsions or effect on seizure threshold, Skin and Appendages - hair Prevalence Magnitude , „ 67 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0536975) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tetramethylammonium chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1062 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Drug / Therapeutic Agent (NLM/NIH/ChemlDPIus) Value 1 5 days -4.18 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Tetramethylammonium hydroxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1063 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetramethylammonium hydroxide 2664 75592 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 5 34 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased relative organ weight Prevalence Magnitude ,,, „ 6 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level; NOEL Type - Repeat Dose Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 35 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tetramethylammonium hydroxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1064 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n semiconductor manufacturing (NLM/NIH/Haz-map) Value 1 5 days -2.47 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Tetrasodium EDTA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1065 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tetrasodium EDTA 2459 64028 Attribute Scores 3-model Categorical Prediction Potency Severity 4 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 250 2,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1966 2004 Critical Effect No observed effects Prevalence Magnitude 8 8 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data, Oser et al, 1 966 Lowest Observed Adverse Effect Level Supplemental Data European Chemicals Bureau; IUCLID Dataset, Tetrasodium ethyleneadiaminetetraacaetate (64-02-8) (2000 CD-ROM edition). Available from the database query page: http://ecb.jrc.it/esis/esis.php as of February 18, 2004. Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 1,750 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tetrasodium EDTA CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1066 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chelating agent (HSDB) Value 60 days 500,000 50 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- Texanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1067 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Texanol 28538 25265774 Attribute Scores 3-model Categorical Prediction Potency Severity 4 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3,200 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect Details of toxic effects not reported otherthan lethal dose value Prevalence Magnitude , „ 85 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (KODAK Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/pagefyear M-158E.1981) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10 "6 cancer risk was used. ------- Texanol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1068 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E, Half life KOC, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M XIOOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes n latex paints; chemical intermediate (OECD/SIDS) Value 1 5 days 20 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Thifensulfuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1069 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Thifensulfuron 66172 79277671 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 Scores based on parent HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.02 Units mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Decreased body weight and body weight gain Prevalence Magnitude , „ 10 7 L Scores based on parent HRL Ratio(s) No water data Notes Reference Dose (for thifensulfuron-m ethyl) Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 140 Y/N Y/N W/L W/L Drinking Water Equivalent Level Based on RfD for thifensulfuron-methyl. 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thifensulfuron CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1070 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 105,145 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 37 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Data for thifensulfuron-methyl Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Derivative of the pesticide thifensulfuron-methyl (HSDB) Value 60 days 38 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Thiocarbazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1071 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Thiocarbazide 12972 2231574 Attribute Scores 3-model Categorical Prediction Potency Severity 7 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 6 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 Critical Effect Behavioral - somno ence (general depressed activity), Behavioral - convulsions or effect on seizure threshold, Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude , „ 57 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 1 17049 Moscow, Russia) No.1- 1993- Volume(issue)/page/year(2),43,1994) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Thiocarbazide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1072 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T1E( Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Veterinary medic ne; microscopy reagent (HSDB) Value 15 days -2.04 5,500 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Thiophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1073 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Thiophenol 4734 108985 Attribute Scores 3-model Categorical Prediction Potency Severity 8 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.00001 0.01 46.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1994 1958 Critical Effect Centrilobular eosinophilic changes Behavioral - changes in motor activity (specific assay), Blood - changes in leukocyte (WBC) count, Biochemical - Enzyme inhibition, induction, or change in blood or tissue evels - transaminases Behavioral - somnolence (general depressed activity), Behavioral - coma, Lungs, Thorax, or Respiration - respiratory depression Prevalence Magnitude ,,, „ 1 7 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 1,7,1994 Supplemental Data AIHAAP American Industrial Hyg ene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year 19,171,1958 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 0.07 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiophenol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1074 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for pesticides, Pharmaceuticals and dyes; mosquito larvicide (HSDB) Value 1 5 days 268 2.52 0.000335 835 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Thiram CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1075 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Thiram 5945 137268 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.015 0.005 0.005 0.01 0.005 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 1992 1993 Critical Effect Changes in hematology, clinical chemistry, incidences of bile duct hyperplasia, & reduction in mean body weight gain Neurotoxicity Neurotoxicity Cardiac - arrhythmias (including changes in conduction), Cardiac - other changes Prevalence Magnitude 95 Li HRL Ratio(s) NC HRL/SWC EEC: 24.4 Notes Reference Dose Reference Dose; Basis = NOEL 5 mg/kg-day, rats, oral, UF = 1000 (DuPont, 1954) Reference Dose Reference Dose; Basis = NOEL/LEL, rats, oral, lowconf, UF = 100, MF = 1 (DuPont, 1954) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in pig; CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993- Volume(issue)/page/year 1,221,1993. Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Vol53; 1991 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 105 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thiram CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1076 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total # Sam pies Amount Released 179,809 34 102,508 #with Detects Units Ibsfyr Ibs/yr Ibs/yr % Samples with detects Number of States 21 5 21 Minimum value of Detects Units States States States Maximum value of Detects Year 1997 2004 2004 Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Supplemental Water Data OPP Estimated Environmental Concentration HRL Ratios (HRL/SWC EEC) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Surface water chronic: 4.3 ug/L Non-cancer: 24.4 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Ground water chronic: 0.84 ug/L Cancer: Pesticide; rubber accelerator; antiseptic (HSDB) Value 1 5 days 10 1.73 3.03E-07 835 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slow (PBT) ------- Thorium-232 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1077 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Thorium-232 18853 7440291 Attribute Scores 3-model Categorical Prediction Potency Severity Prevalence Magnitude 5 8 No further evaluation for CCL - regulated under Radionuclides Rule. HRL Ratio(s) HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 1.01E-10 mg/L risk/pCi (mg/kg-d)-1 (mg/kg-d)"1 pCi = picoCuries Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Thorium-232 CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1078 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water 989 5 0.506 61.7 6 39 59 Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Nuclear reactors; welding; ceramics (HSDB) Value 150,000 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code Notes ------- Tralomethrin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1079 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tralomethrin 42610 66841256 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0075 0.0075 10 99 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Decreased body weight gain; increased water consumption Behavioral - tremor, Behavioral - ataxia, Gastrointestinal - nausea or vomiting Details of toxic effects not reported other than lethal dose value Prevalence Magnitude 8 3 NLi HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose; Basis: NOEL of 0.75 mglkgWay in oral Rat study (Roussel UCLAF, 1 984); UF = 100 Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in dog 13W-C; NTIS National Technical Information Service. (Springfield, VA22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS05451 97 Supplemental Data Rat; PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR47QG, UK) V.1- 1968- Vo ume(issue)/page/year 9,829,1991 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 52.5 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Tralomethrin CCL 3 Contaminant Information Sheet OCCURRENCE DATA1 EPA-OGWDW August 2009 Page 1080 of 1124 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data POP HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 23,767 # PWSs/Sites/ Samples 115 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 15 % PWSs/Sites/ Samples with detects 0 Minimum value of Detects Units States States States Minimum value of Detects Not Detected Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects Not Detected 99% of Detects Not Detected Units for Mag data ug/L Cancer: Notes Pesticide Data Program (USDA) Pesticide; medication (HSDB) Value 180 days 263,000 7.56 3.94E-10 0.08 1 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Tribromoacetic acid (TBAA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1081 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Tribromoacetic acid (TBAA) 2695 75967 Attribute Scores 3-model Categorical Prediction Potency Severity Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N mg/L W/L W/L Prevalence Magnitude 9 8 HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tribromoacetic acid (TBAA) CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1082 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 2,587 #with Detects 89 % PWSs/Sites with detects 3.4 Mean value of Detects 5.77 Maximum value of Detects 19 Median value of Detects 5 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data CAL DHS HRL Ratios (no HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T1n, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # PWSs/Sites/ Samples 40 Units Ibs/yr Ibs/yr Ibs/yr #with Detects 10 Number of States % PWSs/Sites/ Samples with detects 25 Units States States States Minimum value of Detects (ug/L) 1 Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects (ug/L) 15 Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects (ug/L) 4 90% of Detects (ug/L) 7.52 Units for Mag data ug/L Notes Drinking water monitoring; http://www.cdph.ca.gov/certlic/drinkingwater/Pages/Chemicalcontaminan ts.aspx Cancer: Disinfection By-Product Value 15 days 5.3 1.71 3.34E-09 200,000 26 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades slowly ------- Tributyltin chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1083 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tributyltin chloride 11595 1461229 Attribute Scores 3-model Categorical Prediction Potency Severity 7 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0003 15 0.03 Units mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1985 1986 Critical Effect Based on IRIS RfD for TBT oxide, converted to TBTchloride. Immunosuppression Endocrine - other changes, Endocrine - changes in spleen weight, Endocrine - changes in thymus weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 5 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat 2W-C; TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/paqe/year81,274,1985 Supplemental Data Rat; 85JCAE "Prehled PrumysloveToxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year -,1250,1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 2.1 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tributyltin chloride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1084 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former pesticide; chemical intermediate (HSDB) Value 6 days-35 weeks 90,800 60,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (HSDB) ------- Trichloroacetonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1085 of 1124 Contaminant: Substance Key: Contaminant ID (CASRN): Trichloroacetonitrile 7769 545062 Attribute Scores Potency Severity Prevalence Magnitude 8 6 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N mg/L W/L W/L Teratogen 3-model Categorical Prediction HRL Ratio(s) No HRL Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Trichloroacetonitrile CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1086 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water DBP ICR finished water # PWSs/Sites sampled 11,127 #with Detects 192 % PWSs/Sites with detects 1.7 Mean value of Detects 4.23 Maximum value of Detects 41.54 Median value of Detects 0.8 90% of Detects 99% of Detects Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (no HRL) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler Amount Released # Sam pies Units Ibs/yr Ibs/yr Ibs/yr #with Detects Number of States % Samples w/ Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500k 10K-500k Units Ibs/yr Ibs/yr Year 1998 2002 Year Maximum value of Detects Units for Mag data ug/L ug/L ug/L Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Notes Notes National Reconnaissance National Reconnaissance National Aggregate National Aggregate Notes Median value of Detects 95% of Detects Units for Mag data Cancer: Notes Disinfection By-Product Value 60 days 330 2.09 1.34E-06 715 27 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant ------- Triethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1087 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Triethanolamine 4260 102716 Attribute Scores Potency Severity 5 Prevalence Magnitude 8 5 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 10 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data; Maximum Recommended Da ly Dose (MRDD); Incomplete data for attribute scoring Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 2000 Vol. 77 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 23.33 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Triethanolamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1088 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Cancelled pesticide; chemical intermediate; in detergents; chelating agent (HSDB) Value 7 -1 7.10E-13 1,000,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Triethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1089 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Triethylene glyco 5015 112276 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3.57 7,900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1987 Critical Effect Liver -liver function tests impaired, Kidney, Ureter, Bladder - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -transaminases Liver - other changes, Kidney, Ureter, Bladder - other changes Prevalence Magnitude , „ 85 L' HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; (GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- VolumefissueXpagefyear 52(1 2),77,1987) Supplemental Data Guinea pig; VCVGK "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year -,146,1984 Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification IARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 8.33 Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Triethylene glycol CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1090 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log KOW, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >1QOM-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ndustrial solvent; plasticizer; medication (HSDB) Value 10 3.10E-11 39 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIO DEC) ------- Trifluralin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1091 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trifluralin 11820 1582098 Attribute Scores 3-model Categorical Prediction Potency Severity 5 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.024 0.0075 0.0075 0.0075 0.75 25 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1991 Critical Effect Reduced body weight, decreased RBC & hemoglobin evels, increased thrombocyte, methemoglobin, cholesterol & triglyceride levels & increased liver weight. Q1* 0.0058 (mg/kg-day)-1 . Group C. See CAR ncreased liver weight, increase in methemoglobin Liver - changes in liver weight Prevalence Magnitude .,, .,, „ g 2 NL-NL; HRL Ratio(s) NC HRL/NAWQA 90%: 6,222 CARHRL/NAWQA90%:5 Notes Reference Dose Reference Dose; Basis = NOEL 0.75 mg/kg/day, dog, oral, UF = 100 (Hoechst Aktiengesellschaft, 1984a) Reference Dose Reference Dose; Basis = NOEL/LEL, dog, MF = 1 (Hoechst Aktiengesellchaft, 1984) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in dog 3Y-I; NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1 -43-1 1 , Komagome, Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.5 0.0077 0.0058 C 3 mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 2004 Kidney, bladder, thyroid OPP Emmerson etal., 1980 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer CADW Y 0.3 168 5 0.045 Y/N Y/N mg/L W/L W/L mg/L RAISHE Drinking Water Equivalent Level Canadian Drink ng Water Maximum Allowable Concentration 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Trifluralin CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1092 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Units for Mag data ug/L ug/L ug/L ug/L Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NAWQA 90%) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 7,118 # Sam pies Amount Released 22,263,693 0 9,341 # PWSs/Sites sampled 380 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 5.34 % Samples with detects Number of States 46 0 12 % PWSs/Sites with detects 0.0005 Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 6,222 Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 1.74 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.006 Median value of Detects 0.027 90% of Detects 0.15 99% of Detects ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 185 Notes Herbicide (HSDB) Value 180 days 9,682 5.34 0.000103 0.184 3 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Trimellitic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1093 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trimellitic anhydride 7816 552307 Attribute Scores 3-model Categorical Prediction Potency Severity 5 5 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.75 1,900 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1974 Critical Effect Lungs, Thorax, or Respiration - dyspnea Prevalence Magnitude ,,, _ 8 3 NL' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake; No Severity information s available; hence LD 50 used for Potency/Severity scoring. Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Mouse; GTPZAB Gigiena Truda i Professiona 'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V«D Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year 18(7),57,1974 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N M/L M/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For care nogens, the concentration at the 1 0 "6 cancer risk was used. ------- Trimellitic anhydride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1094 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >100M-500M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Preparation of resins, adhesives, polymers, dyes; chem cal intermediate (HSDB) Value 23 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code DF Notes DF = Degrades fast (HSDB) ------- Trimethyl phosphate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1095 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trimethyl phosphate 7393 512561 Attribute Scores 3-model Categorical Prediction Potency Severity 5 8 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 40 70.2 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1997 Critical Effect Peripheral Nerve and Sensation - sensory syndrome diagnostic of central lesion, Behaviora - muscle weakness, Blood - pigmented or nucleated red blood cells Prevalence Magnitude 1 8 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level; Changes in thymus and kidney weight; hematological effects;kidney lesions; nephropathy; decreased copulation rate, decreased fertility index and number of implantation sites; ntrauterine mortality of embryos ncreased. Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat 2.5Y-C; FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher nformation, see TOSCF2 Volume(issue)/page/year 40,75,1997 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.037 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y 0.946 Y/N Y/N W/L W/L Teratogen CACART; RAISHE CACART; UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Trimethyl phosphate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1096 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range 10K-500K 10K-500K Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Gasoline additive; antioxidant (HSDB) Value 7.644 -0.65 7.19E-09 500,000 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (BIODEG) ------- Trimethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1097 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trimethylamine 2657 75503 Attribute Scores 3-model Categorical Prediction Potency Severity 4 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 40 397 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Intestinal lesions. Inflammation, ulceration, and hyperplasia of squamous epithelium; edema of submucosa in Gltract. Prevalence Magnitude 7 7 Li HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 10"* RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 280 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Trimethylamine CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1098 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Organic synthesis; corrosion inhibitor; fungicide (HSDB) Value 29 0.16 890,000 52 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Trimethylolpropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1099 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trimethylolpropane 2780 77996 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.05 800 13,700 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1967 Critical Effect ncreased relative organ weight Behavioral - somnolence (general depressed activity), Lungs, Thorax, or Respiration - dyspnea, Lungs, Thorax, or Respiration - respiratory depression Prevalence Magnitude 7 7 NLi HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake; No Severity information is available; hence NOEL used for Potency/Severity scoring. Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Mouse; HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964- 71. Discontinued. Volume(issue)/page/year 32(5), 288, 1967 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 5,600 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Trimethylolpropane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1100 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >50M-100M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate for polymers (HSDB) Value 1,000,000 40 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (BIODEG) ------- Trinitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1101 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Trinitrotoluene 5251 118967 Attribute Scores 3-model Categorical Prediction Potency Severity 6 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.0005 0.0005 0.0005 0.0005 0.12 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1995 1995 1982 Critical Effect Liver effects (increased relative & absolute liver weight, hepatocytic cloudy swelling & hepatocytom egaly) Liver Liver - changes in liver weight, Endocrine - changes in spleen weight, Blood - changes in spleen Prevalence Magnitude ,,, „ 5 3 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Basis = LOAEL 0.5 mg/kg-d, UF = 1000, dog (U.S. DOD, 1983) Reference Dose; Oral, Int., UF = 1000, endpoint hepatic Reference Dose; Basis = LOAEL, MF = 1 , UF = 1 000, dog (US DOD, 1 983) Minimal Risk Level; Int. Oral, Endpoint = hepatic, UF = 1000 Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in mouse 13W-C; JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year 9,565,1982 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.1 0.03 C 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 1996 Bladder Oral, rat (US DOD, 1984a) Vol. 65 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.02 3.5 1 Y/N Y/N W/L W/L mg/L EPA; RAISHE Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Trinitrotoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1102 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Explosive; chem cal intermediate (HSDB) Value 1,834 1.6 5.48E-07 130 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimation (BIODEG) ------- Triphenyl phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1103 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Triphenyl phosphite 4154 101020 Attribute Scores 3-model Categorical Prediction Potency Severity 5 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 444 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1981 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , „ 6 5 L' HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data (GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Vo ume(issue)/page/year46(12),13,1981) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-dr1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Triphenyl phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1104 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Chemical intermed ate; antioxidant/stabilizer; insect c Value 38 days 6.62 2 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes de synergist (HSDB) Notes BSA = Biodegrades slow with acclimation (PBT) ------- Tris(2,3-dibromopropyl) phospha CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1105 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tris(2,3-dibromopropyl) phosphate 5620 126727 Attribute Scores Potency Severity 7 8 Prevalence Magnitude 1 2 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction NL? HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2.3 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)"1 1999 Vol. 20, Suppl. 7, Vol. 71 ; Cancer classifications were used for screening, but no related quantitative cancer risk data were identified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 0.0152 Y/N Y/N W/L W/L CACART; IARC; OEHHA Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tris(2,3-dibromopropyl) phospha CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1106 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 0 500 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 0 1 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes No longer used in the US; former flame retardant (HSDB) Value 60 days 5,100 4.29 2.60E-05 8 8 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Tris(2-chloroethyl) phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1107 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tris(2-chloroethyl) phosphite 6020 140089 Attribute Scores 3-model Categorical Prediction Potency Severity 6 9 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg mg/kg mg/kg Date 1996 Critical Effect Details of toxic effects not reported other than lethal dose value Prevalence Magnitude , 6 8 L HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Oral, rat (Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1 -3. New York, NY: Van Nostrand Reinhold, 1996., p. 2691) Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tris(2-chloroethyl) phosphite CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1108 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Flame retardant (HSDB) Value 60 days 42 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/reca citrant (PBT) ------- Tris(chloroethyl) phosphate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1109 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Tris(chloroethyl) phosphate 5129 115968 Attribute Scores Potency Severity 5 8 Prevalence Magnitude 10 4 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.3 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Brain - histological lesions. Also causes kidney tumors - adenomas and carcinomas 3-model Categorical Prediction L? HRL Ratio(s) NC HRL/NREC SW MED: 21,000 CAR HRL/NREC SW MED: 25 Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 0.014 3 mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 2,100 2.5 Y/N Y/N W/L W/L RAIS Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Tris(chloroethyl) phosphate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1110 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (HRL/NREC SW MED) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 85 # Sam pies Amount Released # PWSs/Sites sampled 19 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 57.6 % Samples with detects 35 6.13 Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: 21,000 Amount Range >1M-10M >1M-10M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects 0.1 Median value of Detects 0.18 0.195 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: 25 Notes Flame-retardant in plastics and urethanes (HSDB) Value 60 days 301 1.44 2.54E-08 7,000 38 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes BST = Biodegrades sometimes/recalcitrant (PBT) ------- Undecane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1111 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Undecane 10679 1120214 Attribute Scores 3-model Categorical Prediction Potency Severity 4 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 100 2,000 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgflsg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Salivation and decreased food consumption. Prevalence Magnitude ,,, 83 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 700 Y/N Y/N M8/L M8/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "B cancer risk was used. ------- Undecane CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1112 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler ^Samples Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >50M-100M >100M-500M Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Gasoline constituent; research chemical; chemical intermediate (HSDB) Value 8,7 days 6.5 1.93 0.0044 18 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (PBT) ------- Urea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1113 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Urea 2307 57136 Attribute Scores 3-model Categorical Prediction Potency Severity 2 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 3,600 200 8,471 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 2002 1977 1986 Critical Effect Drowsiness and diuresis (nonadverse) Behavioral - tremor, Behavioral - muse e weakness, Gastrointestinal - alteration in gastric secretion Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, 10 5 NL HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data; OPP NOAEL (TRED) Lowest Observed Adverse Effect Level; JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W.Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year 45,566,1977 Supplemental Data GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 51(6), 8,1986 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)"1 (mg/kg-d)"1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 25,200 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Urea CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1114 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; in fertilizers; as medication; de-icer; formerly in pest cide formulations (HSDB) Value 8 -2.11 1.74E-12 545,000 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BF Notes BF = Biodegrades fast (BIODEG) ------- Vanadium pentoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1115 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Vanadium pentoxide 11141 1314621 Attribute Scores 3-model Categorical Prediction Potency Severity 4 1 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.009 0.009 0.5 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1988 1961 Critical Effect Decreased haircystine content. Not an adverse effect. Decreased Potency Score by one integer Decreased hair cystine content Behavioral - alteration of operant conditioning Prevalence Magnitude ,,, ,,, „ 58 HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Basis = NOAEL 0.89 mg/kg-d, rat, oral, UF = 100 (Stokinger et al., 1 953 ) Reference Dose Reference Dose; Basis = NOAEL, MF= 1, rat, UF = 100 (Stokinger et al., 1953) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat 26W-I; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 26(1 0), 6,1 961 Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 63 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vanadium pentoxide CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1116 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M Units Ibs/yr Ibs/yr Year 1986 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Chemical intermed ate; catalyst (HSDB) Value 133 2.97 156 39 Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BST Notes assumed persistent; BST = Biodegradessometimes/recacitrant ------- Vernolate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1117 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Vernolate 12434 1929777 Attribute Scores 3-model Categorical Prediction Potency Severity 6 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.001 0.001 1,200 Units mg/kg-d mgJkg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1986 1991 Critical Effect Decreased body weight in parental animals Decreased weight Details of toxic effects not reported other than lethal dose value Prevalence Magnitude ,,, „ 7 5 NL' HRL Ratio(s) No water data Notes Reference Dose Reference Dose; Basis = NOEL 1 mg/kg-d, UF = 1000, rat, oral (Stauffer Chemical Co., 1983) Reference Dose Reference Dose; Basis = NOEL/LEL, rat, whole body, MF = 1, UF = 1000 (Stauffer Chemical Co., 1983) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Rat; FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year-,C321,1991 Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer 7 Y/N Y/N W/L W/L Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vernolate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1118 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released 181,789 # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States 9 % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes Former herbicide (HSDB) Value 38 425 3.84 3.08E-05 90 16 Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BSA Notes BSA = Biodegrades slow with acclimation (PBT) ------- Vinyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1119 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Vinyl acetate 4660 108054 Attribute Scores 3-model Categorical Prediction Potency Severity 3 3 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 1 0.1 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date 1966 Critical Effect Altered weight Behavioral - alteration of classical conditioning Prevalence Magnitude ,,, 1 1 NL HRL Ratio(s) No data for calculating HRL ratio Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis = NOAEL, MF = 1 , UF = 100, rat, whole body (US EPA, 1 989) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level; oral study in rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2B mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1995 Vol. 63; Cancer classifications were used for screening, but no related quantitative cancer risk data were dentified for potency scoring. Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 7,000 Y/N Y/N W/L W/L 1995 IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vinyl acetate CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1120 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No data for calculating HRL ratio) Production CUSIUR Production Data Use Environmental Fate Parameters T172, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler 794 # Sam pies Amount Released 16,057 3,068,589 # PWSs/Sites sampled 0 #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects 0 % Samples with detects Number of States 8 35 % PWSs/Sites with detects Not Detected Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1B >1B Polymer intermec Value 6.13 0.73 0.000511 20,000 Units Ibs/yr Ibs/yr Year 1998 2002 Not Detected Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Not Detected Median value of Detects Not Detected 90% of Detects Not Detected 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate; in hairspray (HSDB) Units length of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BFA Notes BFA = Biodegrades fast with acclimaton (BIODEG) ------- Vinyl fluoride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1121 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Vinyl fluoride 2618 75025 Attribute Scores Potency Severity Prevalence Magnitude 5 8 Incomplete data for scoring HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect 3-model Categorical Prediction HRL Ratio(s) No HRL; No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Leve Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 2A mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1995 Vol. 63 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y Y/N Y/N W/L W/L CACART; IARC Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vinyl fluoride CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1122 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No HRL; No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >1M-10M XIM-10M Polymer intermec Value 1 5 days 24 1.2 0.12 12,99 61 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate (HSDB); gas Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- Vinyltoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1123 of 1124 Contaminant Substance Key: Contaminant ID (CASRN): Vinyltoluene 28159 25013154 Attribute Scores 3-model Categorical Prediction Potency Severity 5 6 HEALTH EFFECTS DATA1 Non-cancer data EPA OPP RfD EPA IRIS (ITER) RfD EPA HA RfD RAISHE RfD ATSDR (ITER), MRL JMPR, maximum ADI CEDIADI, ADI ITER, TDI Supplemental RfD-like value CTDJPN Highest Chronic NOEL Supplemental NOEL RTECS Lowest Oral Chronic LOAEL Supplemental LOAEL HSDB Lowest Oral LD50 CTDJPN Lowest Oral LD50 RTECS Lowest Oral LD50 Value 0.006 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Date Critical Effect Nasal cavity- lesions Prevalence Magnitude , „ 67 L HRL Ratio(s) No water data Notes Reference Dose Reference Dose Reference Dose Reference Dose; Basis = LOAEL, MF = 1, UF = 1000, mouse, nasal cavity (US EPA, 1987) Minimal Risk Level Acceptable Daily Intake Acceptable Daily Intake Tolerable Daily Intake Supplemental Data No Observed Effect Level Supplemental Data Lowest Observed Adverse Effect Level Supplemental Data Cancer Data EPA Lifetime Cancer Risk, 104 RAISHE Slope Factor OEHHA Slope Factor (oral) EPA Slope Factor EPA Carcinogen classification ARC Carcinogen Classification 3 mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 1994 Vol. 60 Other Supporting Data s contaminant on list of carcinogens? s the contaminant on a list of reproductive toxins? EPAHA-DWEL Health Reference Level (HRL)2 Health Reference Level (HRL)2 cancer Y 42 Y/N Y/N W/L W/L Teratogen UMD Drinking Water Equivalent Level 1 Bolded data indicate value was used in attribute scoring 2 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribut on of 20%. For carcinogens, the concentration at the 1 0 "6 cancer risk was used. ------- Vinyltoluene CCL 3 Contaminant Information Sheet EPA-OGWDW August 2009 Page 1124 of 1124 OCCURRENCE DATA1 # PWSs/Sites sampled #with Detects % PWSs/Sites with detects Minimum value of Detects Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Finished Water Occurrence Data UCMR finished water NCOD Round 1 finished water NCOD Round 2 finished water NIRS finished water Ambient Water Occurrence Data NAWQA ambient water NREC ambient surface water NREC ambient ground water NREC ambient surface water NREC ambient ground water Application/Release NCFAP Pesticide Application - total TRI Release - surface water TRI Release - total Supplemental Water Data HRL Ratios (No water data) Production CUSIUR Production Data Use Environmental Fate Parameters T,a, Half life Koc, Organic Carbon Partition Coefficient log Kow, Octanol Water Partition Coeff. Kd, Distribution coefficient HLC, Henry's Law Constant Water Solubility % water PBT profiler # Sam pies Amount Released # PWSs/Sites sampled #with Detects Units Ibs/yr Ibs/yr Ibs/yr #with Detects % Samples with detects Number of States % PWSs/Sites with detects Minimum value of Detects Units States States States Minimum value of Detects Non-cancer: Amount Range >10M-50M >10M-50M Polymer intermec Value 15 817 3.48 0.00785 89 Units Ibs/yr Ibs/yr Year 1998 2002 Maximum value of Detects Year 1997 2004 2004 Maximum value of Detects Median value of Detects 90% of Detects 99% of Detects Units for Mag data ug/L ug/L ug/L ug/L ug/L ug/L ug/L Units for Mag data ug/L ug/L Notes National Reconnaissance National Reconnaissance Notes National Aggregate National Aggregate Notes Median value of Detects 99% of Detects Units for Mag data Cancer: Notes ate; insecticide component (HSDB) Units ength of time L/kg unitless L/kg atm-m3/mol mg/L Degradation Code BS Notes BS = Biodegrades s ow (PBT) ------- |