United States Prevention, Pesticides EPA 738-R-05-008
Environmental Protection and Toxic Substances September 2005
Agency (7508C)
Reregistration
Eligibility Decision for
Endothall
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Reregistration Eligibility Decision (RED) Document for
Endothall
ListB
Case Number 2245
Approved by: Date:
Debra Edwards, Ph. D.
Director
Special Review and Reregistration Division
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Table of Contents
Endothall Reregi strati on Eligibility Decision Team i
Glossary of Terms and Abbreviations ii
Abstract iv
I. Introduction 1
II. Chemical Overview 2
A Endothall and Salts Nomenclature 3
B. Use Sites 3
C. Formulations 3
D. Methods of application 3
E Use rates 4
F. Annual usage 4
G. Tolerances in Use Profile 4
H Technical Registrant 5
III. Summary of Risk Assessment 5
A. Human Health Risk Assessment 5
1. Hazard Profile 5
2. Dietary Risk (Food) 7
a. Acute Dietary Risk (Food 8
b. Chronic Dietary Risk (Food) 8
3. Cancer Dietary Risk (Food) 10
4. Drinking Water Dietary Risk 10
a. Aquatic Uses 10
b. Terrestrial Uses 12
5. Chronic Risk from Food Plus Drinking Water 12
6. Residential Risk 13
7. Aggregate Risk 14
8. Occupational Risk 14
a. Occupational Handler Summary 15
i. Terrestrial Applications 15
ii. Aquatic Applications 15
iii. Cooling Tower (Biocide) Applications 16
b. Post-application Occupational Risk 16
9. Human Incident Summary 17
B. Ecological Risk 17
1. Environmental Fate and Transport 17
2. Terrestrial Organism Risk 18
a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 18
3. Aquatic Organism Risk 19
a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 19
b. Risks from Use of Endothall Dipotassium Salt 20
c. Risks from Endothall Acid 20
4. Risk to Endangered Species 21
a. Risks from Use of Endothall N, N-dimethylalkylamine Salt 21
b. Risks from Use of Endothall Dipotassium Salt 22
in
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IV. Risk Management, Reregi strati on, and Tolerance Reassessment Decision 22
A. Determination or Reregi strati on Eligibility 22
B. Public Comments and Responses 23
C. Regulatory Position 23
1. Food Quality Protection Act Findings 23
a. "Risk Cup" Determination 23
b. Determination of Safety to U.S. Population (Including Infants and Children) 24
c. Endocrine Disrupter Effects 24
d. Cumulative Risks 25
2. Tolerance Summary 25
a. Tolerances Currently Listed and Tolerance Reassessment 27
D. Regulatory Rationale 28
a. Dietary Risk Mitigation (food and drinking water) 28
1. Human Health Risk Management 29
a. Occupational Risk Mitigation 29
b. Residential Risk Mitigation 29
2. Environmental Risk Management 30
a. Dipotassium Salt 30
b. N, N-dimethylalkylamine Salt 30
3. Significance of Endothall Use 30
4. Other Labeling Requirements 31
5. Threatened and Endangered Species Considerations 32
a. The Endangered Species Program 32
b. General Risk Mitigation 32
V. What Registrants Need to Do 33
A. Manufacturing Use Products 34
1. Additional Generic Data Requirements 34
2. Labeling for Technical and Manufacturing Use Products 35
B. End-Use products 36
1. Additional Product-Specific Data Requirements 36
2. Labeling for End-Use Products 36
a. Label Changes Summary Table 36
VI. Appendices 47
A. Table of Use Patterns for Endothall 48
B.Generic Data Requirements and Studies Used to Make the Reregi strati on Decision63
C. Technical Support Documents 70
D. Bibliography 73
E. Generic Data Call-In 154
F. Product Specific Data Call-In 177
G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data
Requirements for Reregi strati on 204
H. List of Registrants Sent Data Call-Ins 206
I. List of Available Related Documents and Electronically Available Forms 207
IV
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Endothall Reregistration Eligibility Decision Team
Special Review and Reregi strati on Division
Mika J. Hunter
Anne Overstreet
Robert McNally
Health Effects Division
Robert Zendzian
David Soderberg
Seyed (Nader) Tadayon
Louis (Gino) Scarano
Environmental Fate and Effects Division
Michelle Embry
Michael Davy
Dana Spatz
Antimicrobial Division
Kathryn Montaque
Timothy Leighton
Biological and Economic Analysis Division
Bill Phillips
TJ Wyatt
Steve Jarboe
Registration Division
Joanne Miller
Jim Stone
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Glossary of Terms and Abbreviations
AGDCI
ai
aPAD
BCF
CFR
cPAD
CSF
CSFII
DCI
DEEM
DFR
DNT
EC
EDWC
EEC
EPA
EUP
FDA
FIFRA
FFDCA
FQPA
GLN
IR
LC50
LD
'50
LOC
LOAEL
MATC
mg/kg/day
mg/L
MOE
MRID
MUP
NOAEL
OPP
OPPTS
PAD
PCA
PDF
PHED
PHI
ppb
PPE
ppm
Agricultural Data Call-In
Active Ingredient
Acute Population Adjusted Dose
Bioconcentration Factor
Code of Federal Regulations
Chronic Population Adjusted Dose
Confidential Statement of Formulation
USDA Continuing Surveys for Food Intake by Individuals
Data Call-In
Dietary Exposure Evaluation Model
Dislodgeable Foliar Residue
Developmental Neurotoxicity
Emulsifiable Concentrate Formulation
Estimated Drinking Water Concentration
Estimated Environmental Concentration
Environmental Protection Agency
End-Use Product
Food and Drug Administration
Federal Insecticide, Fungicide, and Rodenticide Act
Federal Food, Drug, and Cosmetic Act
Food Quality Protection Act
Guideline Number
Index Reservoir
Median Lethal Concentration. A statistically derived concentration of a substance that
can be expected to cause death in 50% of test animals. It is usually expressed as the
weight of a substance per weight or volume of water, air, or feed, e.g., mg/1, mg/kg, or
ppm.
Median Lethal Dose. A statistically derived single dose that can be expected to cause
death in 50% of the test animals when administered by the route indicated (oral, dermal,
inhalation). It is expressed as a weight of substance per unit weight of animal, e.g.,
mg/kg.
Level of Concern
Lowest Observed Adverse Effect Level
Maximum Acceptable Toxicant Concentration
Micrograms Per Gram
Micrograms Per Liter
Milligram Per Kilogram Per Day
Milligram Per Liter
Margin of Exposure
Master Record Identification Number. EPA's system for recording and tracking studies
submitted.
Manufacturing-Use Product
No Observed Adverse Effect Level
EPA Office of Pesticide Programs
EPA Office of Prevention, Pesticides, and Toxic Substances
Population Adjusted Dose
Percent Crop Area
USDA Pesticide Data Program
Pesticide Handler's Exposure Data
Pre-harvest Interval
Parts Per Billion
Personal Protective Equipment
Parts Per Million
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PRZM/EXAMS Tier II Surface Water Computer Model
RAC Raw Agriculture Commodity
RED Reregistration Eligibility Decision
REI Restricted Entry Interval
RfD Reference Dose
RQ Risk Quotient
SCI-GROW Tier I Ground Water Computer Model
SAP Science Advisory Panel
SF Safety Factor
SLC Single Layer Clothing
TGAI Technical Grade Active Ingredient
USDA United States Department of Agriculture
USGS United States Geological Survey
UF Uncertainty Factor
UV Ultraviolet
WPS Worker Protection Standard
111
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Abstract
This document presents the Environmental Protection Agency's (hereafter
referred to as EPA or the Agency) decision regarding the reregi strati on eligibility of the
registered uses of endothall. The Agency has determined that endothall is eligible for
reregi strati on. Endothall is used as an aquatic herbicide, a desiccant, and a biocide.
Endothall is applied as either the dipotassium salt or the N, N-dimethylalkylamine salt.
There are currently seven tolerances established for endothall. The Agency has
conducted human health and environmental fate and ecological effect risk assessments
for endothall and reassessed all the existing tolerances. The risk conclusions of these
assessments are summarized below.
In the human health risk assessment, chronic dietary risks (food and drinking
water) do not exceed the Agency's level of concern, although drinking water risk for
infants less than one year old is at the level of concern. However, the Agency believes
that this risk estimate is the result of conservative assumptions and is discussed in detail
in section III.5 of this document. Aggregate risks (food, drinking water, and residential
exposure) also do not exceed the Agency's level of concern. To ensure that endothall
exposures from drinking water do not result in risks of concern, the Agency is requiring
that direct applications to water not be applied less than 600 feet from an active drinking
water intake.
For terrestrial uses of endothall, all risks calculated for short-term and
intermediate-term occupational exposures are below the Agency's level of concern with
the exception of mixing and loading liquids for aerial applications. The Agency is
requiring that workers mixing and loading liquids for aerial applications wear an 80%
(PF5) respirator (NIOSH TC-21C). All risks for short-term and intermediate-term
exposures from mixing, loading, and applying liquid formulations to aquatic use sites are
below the Agency's level of concern when workers wear an 80% (PF5) respirator
(NIOSH TC-21C). All risks for short-term exposures from loading and applying granular
formulations for aquatic applications are below the Agency's level of concern when
workers wear baseline protective equipment. For intermediate-term exposures from
loading and applying granular formulations for aquatic applications, risks are of concern
to the Agency. To protect workers in this scenario, workers are required to wear a 90%
respirator (PF10 elastomeric half-face respirator with the appropriate cartridge, NIOSH
TC-23C or NIOSH TC- 14G). All occupational risks from use of endothall as a biocide in
cooling towers are below the Agency's level of concern.
Technical endothall is classified as a severe dermal irritant. However, this
regulatory decision does not include specific mitigation to address these dermal effects.
Appropriate worker protections and label language will be established based on end-use
product acute toxicity during product reregi strati on. Product reregi strati on follows active
ingredient reregi strati on. A 48-hour re-entry interval is currently on labels for terrestrial
uses and will be retained. In addition, a double notification statement to further protect
workers will be added to endothall labels intended for terrestrial use.
IV
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Ecological risks were identified as a result of endothall use in terrestrial and
aquatic settings. To potentially reduce risks to non-target plants and organisms, the
Agency is requiring that endothall labels differentiate application rates for small and large
applications of endothall dipotassium salt. Labels will specify that higher rates are only
to be used for small, spot treatments, and lower rates are to be used for larger treatments.
In addition, the use of N, N-dimethylalkylamine salt in lakes, streams, and ponds will be
limited to algae, Hygrophila, Vallisneria, Hydrilla, Cabomba, bur-weed, Elodea
canadensis, and Brazilian elodea.
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I. Introduction
The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was amended
in 1988 to accelerate the reregi strati on of products with active ingredients registered prior
to November 1, 1984 and amended again by the Pesticide Registration Improvement Act
of 2003 to set time frames for the issuance of Reregi strati on Eligibility Decisions. The
Act calls for the development and submission of data to support the reregi strati on of an
active ingredient, as well as a review of all submitted data to the U.S. Environmental
Protection Agency (EPA or the Agency). Reregi strati on involves a thorough review of
the scientific database underlying a pesticide's registration. The purpose of the Agency's
review is to reassess the potential hazards arising from the currently registered uses of a
pesticide; to determine the need for additional data on health and environmental effects;
and to determine whether or not the pesticide meets the "no unreasonable adverse effects"
criteria of FIFRA.
On August 3, 1996 the Food Quality Protection Act of 1996 (FQPA) was
signed into law. This Act amended FIFRA and the Federal Food Drug and Cosmetic Act
(FFDCA) to require reassessment of all existing tolerances for pesticides in food. FQPA
also requires EPA to review all tolerances in effect on August 3, 1996 by August 3, 2006.
In reassessing these tolerances, the Agency must consider, among other things, aggregate
risks from non-occupational sources of pesticide exposure, whether there is increased
susceptibility among infants and children, and the cumulative effects of pesticides that
have a common mechanism of toxicity. When the Agency determines that aggregate
risks are not of concern and concludes that there is a reasonable certainty of no harm
from aggregate exposure, the tolerances are considered reassessed. EPA decided that, for
those chemicals that have tolerances and are undergoing reregistration, tolerance
reassessment would be accomplished through the reregistration process.
As mentioned above, FQPA requires EPA to consider "available
information" concerning the cumulative effects of a particular pesticide's residues and
"other substances that have a common mechanism of toxicity" when considering whether
to establish, modify, or revoke a tolerance. Potential cumulative effects of chemicals
with a common mechanism of toxicity are considered because low-level exposure to
multiple chemicals causing a common toxic effect by a common mechanism could lead
to the same adverse health effect as would a higher level of exposure to any one of these
individual chemicals. For information regarding EPA's efforts to determine which
chemicals have a common mechanism of toxicity and to evaluate the cumulative effects
of such chemicals, see the policy statements released by EPA's Office of Pesticide
Programs concerning common mechanism determinations and procedures for cumulating
effects from substances found to have a common mechanism on EPA's website at
http://epa.gov/pesticides/cumulative/.
The Agency has found no information indicating endothall shares a
common mechanism of toxicity with other substances. Endothall does not appear to
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produce a toxic metabolite produced by other substances. Therefore, for the purposes of
tolerance reassessment and a decision on reregi strati on eligibility, EPA has not assumed
that endothall shares a common mechanism of toxicity with other compounds. In the
future, if additional information suggests endothall shares a common mechanism of
toxicity with other compounds, additional testing may be required and a cumulative
assessment may be necessary.
This document presents EPA's revised human health and ecological risk
assessments, its progress toward tolerance reassessment, and the reregi strati on eligibility
decision for endothall. The document consists of six sections. Section I contains the
regulatory framework for reregi strati on/tolerance reassessment. Section II provides a
profile of the use and usage of the chemical. Section III gives an overview of the revised
human health and ecological risk assessments based on data, public comments, and other
information received in response to the preliminary risk assessments. Section IV presents
the Agency's reregi strati on eligibility and risk management decisions. Section V
summarizes label changes necessary to implement the risk mitigation measures outlined
in Section IV. Section VI provides information on how to access related documents.
Finally, the Appendices list related information and supporting documents. The
preliminary and revised risk assessments for endothall are available in the Public Docket,
under docket number OPP-2004-0370 and on the Agency's web page,
http ://www/epa.gov/edockets.
II. Chemical Overview
Endothall is in the dicarboxylic acid class of chemicals. Endothall is applied as
either a dipotassium salt or an N, N-dimethylalkylamine salt. Endothall acid is not
directly applied to use sites; it is formed as a breakdown product resulting from
application of the salt forms. The amine salt is the only form applied terrestrially, while
both the dipotassium and amine salt are applied to aquatic use sites. The amine salt is
also used to control algae and invasive mollusks in cooling towers. The majority of
endothall is used in aquatic environments.
Endothall acid is a selective contact herbicide. Endothall acid works by
interfering with plant respiration, by affecting protein and lipid biosynthesis, and by
disrupting plant cell membranes.
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A. Endothall and Salts Nomenclature
Endothall, acid
Molecular Formula
CAS Name
CAS Number
PC Code
CgHioOs
7-oxabicyclo[2.2. l]heptane-2,3-dicarboxylic acid
145-73-3
038901
Endothall, dipotassium salt
Molecular Formula
CAS Name
CAS Number
PC Code
CgHgK^Os
N/A
2164-07-0
038904
Endothall, mono-N,N-dimethylalkylamine salt
Molecular Formula
CAS Name
CAS Number
PC Code
CioHi7N05
N/A
66330-88-9
038905
B. Use Sites
Endothall is used as an aquatic herbicide to control submerged aquatic
vegetation and algae in lakes, ponds, and irrigation canals.
• Endothall is also used as a desiccant on potatoes, hops, cotton, clover, and
alfalfa. Tolerances are established for sugar beets and rice straw, although
current labels do not allow applications to these crops.
• Endothall has one biocide use to control mollusks and algae in cooling
towers/systems.
C Formulations
Formulated as either a granular or a soluble concentrate (liquid).
D. Methods of application
For aquatic applications, endothall dipotassium salt and endothall N, N-
dimethylalkylamine salt can be applied as a granular or a liquid. Granular
applications are made using centrifugal or blower-type spreaders that are
mounted to boats. Granular formulations can also be applied to aquatic
sites by spreader equipment attached to helicopters. Liquid applications
are made using low pressure hand wand sprayers, hand-gun sprayers, or
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direct metering systems. Aerial application of liquids to aquatic sites is
prohibited.
For terrestrial applications, endothall is applied as a liquid. Terrestrial
liquid applications can be made with either ground or aerial equipment.
Only endothall N, N-dimethylalkylamine salt is used on terrestrial sites.
E. Use rates
Maximum single application rates are 5 ppm for aquatic applications and 2
Ibs acid equivalents/Acre for terrestrial applications. Application rates of
both the salt forms of endothall are expressed as acid equivalents (ae) to
equalize the application rates in terms of the acid.
F. Annual usage
In terms of pounds used, endothall is most readily used as an aquatic
herbicide. For terrestrial endothall uses, the majority of use is on potatoes
(approximately 5% crop treated) and cotton (less than 2.5% crop treated).
Of the two forms of endothall, the N, N-dimethylalkylamine salt accounts
for the most use.
G. Tolerances in Use Profile
• There are currently five tolerances for endothall and its salts listed in CFR
§ 180.293(a)(l) on cotton seed (0.1 ppm), hops (0.1 ppm), potato (0.1
ppm), rice grain (0.05 ppm), and rice straw (0.05 ppm). One tolerance is
listed in CFR § 180.319 for sugar beets (0.2 ppm).
A tolerance is currently listed for potable water (0.2 ppm, CFR §
180.293(a)(2). The Agency is proposing that this tolerance be revoked.
Currently, EPA's Office of Water has an MCL established for endothall.
• The Agency is proposing tolerances for cotton gin byproducts, animal
commodities, processed commodities, and irrigated crops. When
acceptable data are received these tolerances will be established.
The registrant has proposed tolerances for fish and shellfish. This action
is not incorporated into this document and will be addressed in a separate
action. However, a fresh water fmfish residue level of 0.1 ppm was
included in the dietary exposure assessment. Current food consumption
models cannot include residues in freshwater shellfish adequately; so
freshwater shellfish were not incorporated into the current assessment, and
were considered as a negligible source of residues.
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H Technical Registrant
• Cerexagri, Inc.
III. Summary of Risk Assessment
A. Human Health Risk Assessment
1. Hazard Profile
(For a complete discussion, see section 4 of Endothall: HED Chapter of the
Reregi strati on Eligibility Decision Document, Corrected Following Public Comments,
dated September 30, 2005.)
The toxicological database for endothall is considered complete.
Endothall is Toxicity Category I by the oral, and ocular routes, and is a skin sensitizer.
For dermal and inhalation toxicity, endothall is categorized as mildly toxic.
For dermal exposure, a toxicity endpoint was not identified, and a dermal risk
assessment was not conducted since endothall is so toxic at the portals of entry and is
therefore self-limiting. In the 21-day dermal toxicity study, in addition to weight loss,
severe local effects were observed at the lowest dose tested, 30 mg/kg/day. Total body
weight gain was also inhibited. The study indicated that systemic and local effects were
co-occurant. Therefore, the Agency has determined that endothall will be classified as a
severe dermal irritant. Label requirements addressing dermal effects through double
notification will be placed on technical and end-use products. End-use products
generally contain a lower percentage of active ingredient and it is appropriate to consider
additional label requirements relating to endothall's dermal effects during product
reregi strati on.
Endothall is not a neurotoxicant, nor does it induce developmental toxicity.
Endothall is classified as "not likely to be carcinogenic to humans" and has no mutagenic
potential. Endothall does not bioaccumulate.
Table 1. Acute Toxicity Data for Endothall
Guideline Number
Study Type
870. 1 100 Acute Oral Toxicity
870. 1200 Acute Dermal Toxicity
870. 1300 Acute Inhalation Toxicity
870.2400 Acute Eye Irritation
870.2500 Acute Dermal Irritation
870.2600 Skin Sensitization
MRID Number
42289201
42289202
42169501
42289203
42289204
(unacceptable)
41871901
Toxicity Category
I
III
II
I
la
Yes
a. Endothall has been shown to be a skin irritant in a preliminary range finding study for the dermal
absorption study (42169503) and the 21-day dermal toxicity study (43465201). This information is
considered sufficient to classify endothall as a severe dermal irritant.
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Although endpoints for all exposure scenarios were selected from the same study,
it is important to note that for each scenario, different toxicity endpoints are appropriate.
The two short-term exposure scenarios (1-30 days, incidental oral and short-term
inhalation) use a separate endpoint (NOAEL of 9.4 mg/kg/day) based on decreases in
body weight in offspring of endothall-treated parents. The remaining, longer-term
scenarios use a more conservative value (LOAEL of 2 mg/kg; divided by 3 to extrapolate
to an estimated NOAEL of 0.7 mg/kg) to accommodate the longer exposure scenarios.
Because an inhalation study is not currently available (a 28-day inhalation study is being
required), the inhalation exposure scenario uses an oral study assuming 100% absorption.
Table 2. Summary of Toxicological Doses and Endpoints for Endothall Used in the
Human Health Risk Assessment
Exposure Scenario
Dose Used in Risk
Assessment, TJF
Special FQPA SF*
and Level of Concern
for Risk Assessment
Study and Toxicological
Effects
Acute Dietary
(All Populations)
An appropriate endpoint attributable to a single dose was not available from any
study, including the prenatal developmental toxicity study in rats. An acute RfD
was not established.
Chronic Dietary
(All Populations)
LOAEL = T
mg/kg/day
UF = 300
(10X for intraspecies
variations, 1 OX for
interspecies
differences, and 3X
for extrapolation
from LOAEL to
NOAEL)
Chronic RfD =
0.007 mg/kg/day
FQPA SF = IX
cPAD =
chronic RfD
FQPA SF
= 0.007 mg/kg/day
2-generation reproduction study
in rats
LOAEL of 2 mg/kg/day based
on proliferative lesions of the
gastric epithelium in both sexes.
(MRID43152101)
Short-term
Incidental Oral
(1-30 days)
NOAEL=9.4'
mg/kg/day
UF = 100
(10X for intraspecies
variations, 1 OX for
interspecies
differences)
Residential MOE = 100
2-generation reproduction study
in rats
LOAEL of 60 mg/kg/day based
on decreased pup body weight
in both sexes on Day 0 of
second and third generations.
(MRID43152101)
Intermediate-term
Incidental Oral (1-6
months)
LOAEL= 2 z
mg/kg/day
UF = 300
(10X for intraspecies
variations, 1 OX for
interspecies
differences, and 3X
for extrapolation
from LOAEL to
NOAEL)
Residential MOE = 300
2-generation reproduction study
in rats
LOAEL of 2 mg/kg/day based
on proliferative lesions of the
gastric epithelium in both sexes.
(MRID43152101)
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Exposure Scenario
Short-term
Inhalation
(1-30 days)
Intermediate-Term
Inhalation
(1-6 months)
and Long-Term
Inhalation
Cancer (oral,
dermal, inhalation)
Dose Used in Risk
Assessment, TJF
NOAEL=9.4'
mg/kg/day
UF= 100
(10X for intraspecies
variations, 1 OX for
interspecies
differences)
(inhalation absorption
rate is assumed to be
100% of oral dose;
default assumption)
LOAEL = 2 2
mg/kg/day
UF = 300
(10X for intraspecies
variations, 1 OX for
interspecies
differences, and 3X
for extrapolation
from LOAEL to
NOAEL)
Special FQPA SF*
and Level of Concern
for Risk Assessment
Resrdentral MOE = 100
Occupational MOE =
100
Residential MOE = 300
Occupational MOE =
300
Study and Toxicological
Effects
2-generation reproduction study
in rats
LOAEL of 60 mg/kg/day based
on decreased pup body weight
(both sexes) on Day 0 in both
Fl andF2 generations.
(MRID 43152101)
2-generation reproduction study
in rats
LOAEL of 2 mg/kg/day based
on proliferative lesions of the
gastric epithelium in both sexes.
(MRID 43152101)
Classified as "not likely to be carcinogenic to humans"
(MRID 41040301, 40685301, 43608301)
UF= uncertainty factor, FQPA SF = Special FQPA safety factor, LOAEL = lowest observed adverse effect
level, PAD = population adjusted dose (c = chronic), RfD = reference dose, MOE = margin of exposure
1. The NOAEL of 9.4 mg/kg/day is derived from the offspring LOAEL of 60 mg/kg/day for the endpoint
referenced in the table.
2. The LOAEL of 2 mg/kg/day is derived from the parental LOAEL of 2 mg/kg/day for the endpoint
referenced in the table.
2. Dietary Risk (Food)
(For a complete discussion, see Section 6.0 of Endothall: HED Chapter of the
Reregi strati on Eligibility Decision Document, Corrected Following Public Comments,
dated September 30, 2005.)
The dietary risk assessment incorporates both exposure to and toxicity of a given
pesticide. The risk is expressed as a percentage of a maximum acceptable dose (i.e., the
maximum dose which will result in no unreasonable adverse health effects). This dose is
referred to as the population adjusted dose (PAD). The PAD is equivalent to the
Reference Dose (RfD) divided by the special FQPA Safety Factor. EPA is concerned
when estimated dietary risk exceeds 100% of the PAD. The endothall dietary risk
assessment was performed using the Dietary Exposure Evaluation Model (DEEM™).
Table 2 above lists the endpoints used in the dietary risk assessment.
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The Special FQPA Safety Factor was reduced to IX because there are no residual
exposure uncertainties, no sensitivity to infants and children, and the toxicity database is
essentially complete. The uncertainty factor (UF) for chronic dietary exposure to
endothall was determined to be 300. This takes into consideration a factor of 10X for
interspecies variation, 10X for intraspecies variation, and 3X for the lack of a NOAEL in
the study used for endpoint selection. When evaluating the toxicological database for
endothall, the primary effects are seen at the point of entry (i.e., oral) and the weight of
evidence suggests that endothall will be of no developmental concern. This evidence
includes the results of a developmental toxicity study with rats, where endothall did not
induce developmental toxicity at any of the doses tested. Effects that were observed in
developmental toxicity studies (decreased pup weight gain) are not considered to be
developmental toxicity effects. Therefore, no additional uncertainty factors were added
for the lack of a rabbit developmental toxicity study. However, a rabbit developmental
toxicity study is being required as confirmatory data.
Endothall metabolism results in either the formation of the monomethyl ester or
complete decomposition into natural constituents of plant and animal tissues. The
residues of concern in plants and animals are endothall and its monomethyl ester.
a. Acute Dietary Risk (Food)
No endpoint was identified for acute dietary exposures because the acute toxicity
database is complete and does not suggest there is a potential acute risk concern.
Normally, an acute hazard value is chosen from acute (non-lethal), sub chronic, or
developmental toxicity studies from which there is reasonable evidence that a single
exposure can lead to a potential effect. Endothall is known to cause primarily local
effects depending on the route of exposure. In the developmental rat study, there was
evidence of a decrease in body weight gain in pregnant rats after a single exposure of
endothall. However, this effect was coupled with a decrease in food consumption and the
treated rats recovered by the end of gestation. At all time points, there was no difference
in treated versus control body weights. Therefore, the available data suggests that a
single exposure to endothall does not result in an effect of concern for risk assessment
purposes. The Agency does not expect acute risks resulting from dietary exposure.
b. Chronic Dietary Risk (Food)
The chronic dietary risk endpoint for all populations was selected from the two-
generation reproduction toxicity study using rats as the test subject. The endpoint of
concern was proliferate lesions of the gastric epithelium, which was observed in both
sexes. The Lowest Observed Adverse Effect Level (LOAEL) is 2 mg/kg/day in males
and 2.3 mg/kg/day in females.
For the chronic dietary exposure assessment, an estimate of the residue level in
each food or food-form on the food commodity residue list is multiplied by the average
daily consumption estimate for that food/food-form. The resulting residue consumption
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estimate is summed with the residue consumption estimates for all other food/food forms
on the commodity residue list to arrive at the total average estimated exposure. Exposure
is expressed in mg/kg body weight/day and risk is expressed as a percent of the chronic
PAD (cPAD).
Food items may be exposed to residues of endothall in two ways: via direct
application, or via irrigation water previously treated with endothall. To assess residues
on food from the two uses, two assessments were performed. One assessment took into
consideration only exposure to crops that are directly treated with endothall. The second
assessment incorporated exposure to crops directly treated with endothall and crops that
were irrigated with endothall-treated water. To assess exposures from both of these
scenarios, a DEEM™ analysis was performed.
The results of the DEEM™ analysis using exposure from only directly treated
crops was 1.2% of the cPAD for the general population. The most highly exposed
population subgroup was children 3-5 years old with an exposure estimate of 3.0% of the
cPAD. These results are based on tolerance level residues and 100% crop treated and are
considered to be conservative estimates of chronic dietary risk.
When calculating residues on crops irrigated with endothall-treated water, an
assumption that all crops are irrigated with water containing endothall was initially used
directly in the DEEM1 program. This assumption led to an overestimate of exposure
from irrigated crops. Using the amount of endothall produced per year, and information
from the U.S. Geological Survey concerning irrigation practices, the Agency was able to
refine exposure estimates. To conservatively address errors in this estimation and to
assure that regional and crop differences in irrigation, and differences in consumption of
crops are taken into consideration, a percent of the crops irrigated with treated irrigation
water was conservatively estimated to be 1%. The actual increase in exposure to
endothall through irrigation should be less than 1% of that originally estimated by
DEEM™. Therefore, the results from the DEEM™ analysis for the portion of exposure
due to irrigated crops were multiplied by a factor of 0.01. The results of the DEEM™
exposure analysis for exposure from directly treated crops and irrigated crops was 2.7%
of the cPAD for the general population, and 7.8% cPAD for children 1-2 years old.
Therefore, chronic dietary risks (food) are below the Agency's level of concern.
For a complete discussion of exposure to endothall from consumption of irrigated
crops, please see "Endothall and its salts: Addendum to Chronic Dietary Exposure
Assessment for the Reregi strati on Eligibility Decision", dated September 29, 2005.
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Table 3. Summary of Chronic Dietary Exposure and Risk from Endothall (Directly
Treated Crops and Crops Irrigated with 5 ppm Endothall)
Population Subgroup
General U.S. Population
Children 1-2 years old
Dietary Exposure
mg/kg/day
0.000189
0.000544
% cPAD
2.7
7.8
3. Cancer Dietary Risk (Food)
The Agency has classified endothall as "not likely to be carcinogenic to humans"
based on the lack of evidence of carcinogenicity in mice or rats.
4. Drinking Water Dietary Risk
(For a complete discussion, see Section 6.2 of the Endothall: HED Chapter of the
Reregi strati on Eligibility Decision Document, Corrected Following Public Comments,
dated September 30, 2005.)
Drinking water exposure to pesticides can occur through groundwater and surface
water contamination. EPA considers both acute (one day) and chronic (lifetime) drinking
water risks and uses either modeling or actual monitoring data, if available, to estimate
those risks. For endothall, only non-cancer chronic dietary exposure from drinking water
was assessed. As previously stated, an endpoint for acute dietary exposure was not
identified and acute dietary risks are not of concern to the Agency. For endothall,
drinking water exposure takes into consideration potential exposure from terrestrial,
aquatic, and industrial (biocide) uses. Also, endothall is considered "not likely to be
carcinogenic in humans".
a. Aquatic Uses
Direct applications to water were modeled assuming uniform application over an
entire reservoir at the maximum labeled rate. Based on these assumptions, the peak
(acute) concentration of endothall in surface water was estimated to be 5000 |ig/L, and
the annual mean (chronic) concentration was estimated to be 545 |ig/L. EPA believes it
is highly unlikely that concentrations of endothall would reach these levels in areas where
surface water is directly used for drinking water for several reasons:
• The assumption that 100% of a water body is treated with endothall at the
maximum label rate is conservative and highly unlikely. Typically,
endothall is applied as a peripheral treatment around boat docks and piers,
so that only a small percentage of a water body is treated.
• Endothall treatments are made to the upper 3 to 5 feet of the water body,
whereas drinking water intakes are typically located at the deepest point in
municipal reservoirs where endothall concentrations would be expected to
be lower.
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• Monitoring data for endothall suggest the average concentrations of
endothall in drinking water are well below the modeled estimates.
Monitoring data for finished water are available from the National
Contaminant Occurrence Database (NCOD) for both surface and ground
water. Detectable residues of endothall were found in only 7 of 27,494 or
0.025% of ground water samples and 8 of 5,112 or 0.15% of surface water
samples.
The maximum detected concentrations in ground and surface water
were 4,550 ppb and 2,900 ppb, respectively; and the mean concentration
for samples with detectable residues was 670 ppb in ground water and 865
ppb in surface water. Although these few values are well above the
established Maximum Contaminant Level (MCL) for endothall of 100
ppb, greater than 99% of ground and surface water samples contained
concentrations below the limit of detections (10 ppb). Endothall may be
applied to water at concentrations up to 5000 ppb. These high values
would not be representative of average concentrations in drinking water.
This determination is further supported by additional monitoring data
collected under the Safe Drinking Water Act (SOWA). Data collected
under the Safe Drinking Water Information System (SDWIS) between
1993 and 2005 indicated only 2 occurrences of endothall residues that
exceeded the established MCL of 100 ppb. Both of these occurred in
1994, with no violations occurring since that time. In addition, historical
data analysis of compliance and occurrence data from treated water
systems has shown detections of very low frequency to be outliers relative
to whole datasets. Given the low frequency of detection and the more than
an order of magnitude difference between the more than 27,000 samples
below the detection limit and 8 detects above, the observed detects would
appear to be statistical outliers.
For these reasons, EPA does not believe the modeled estimated concentrations are
appropriate for use in estimating exposure to endothall in drinking water. As noted
above, an MCL of 100 ppb has been established for endothall. The MCL is based on a
chronic feeding study which established a NOEL of 2 mg/kg/day based on increased
absolute relative weights of the stomach and small intestine. Although the MCL is likely
to overestimate average (i.e., chronic) residues of endothall in drinking water, EPA
believes it provides a reasonable high-end estimate of potential drinking water
concentrations from the aquatic uses of endothall. Consequently, the MCL of 100 ppb
was used in the dietary risk assessment.
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b. Terrestrial Uses
Surface water concentrations from use on terrestrial crops were estimated using
the Tier II model PRZM (version 3.12)/EXAMS (version 2.98.04) and ground water
concentrations were estimated using the Tier I model of SCIGROW (version 2.2). A
total of five scenarios were modeled for endothall use on terrestrial crops based on
Agency standard scenarios. The scenarios modeled were cotton and alfalfa in California,
Oregon hops, and potatoes in Maine and Idaho. These scenarios were chosen to estimate
the concentration of endothall in surface drinking water over a geographically dispersed
range of existing terrestrial crop production areas. These scenarios chosen for this
assessment represent all relevant PRZM/EXAMS scenarios for the terrestrial use of
endothall. Endothall may be applied by aerial or ground equipment as per the labels of
this product. All terrestrial scenarios were modeled with aerial application equipment,
which results in the highest amount of spray drift, except for hops, which is treated by
ground equipment.
The estimated peak surface water concentration of endothall as a result of
terrestrial use is 7.1 ppb. The estimated chronic (non-cancer) surface water concentration
of endothall as a result of terrestrial use is 2.5 ppb. Modeled groundwater concentrations
of endothall, both peak and chronic, are not expected to exceed 0.086 ppb.
5. Chronic Risk from Food Plus Drinking Water
To assess chronic risk from food plus drinking water, exposure estimates from
both chronic dietary (both directly treated and irrigated crops) and chronic drinking water
were combined in the DEEM™ modeling program. Estimated concentrations of
endothall were modeled by the Agency as discussed above. Based on the rationale
described above, the Agency assumed an endothall concentration of 100 ppb as the
average concentration in drinking water. This concentration is the MCL for endothall.
Because the Agency feels that modeled concentrations are not appropriate for use in
estimating exposure to endothall in drinking water, the MCL of 100 ppb was used.
Chronic dietary risks (food and drinking water) do not exceed the Agency's level
of concern, although drinking water risk for infants less than one year old is at the level
of concern. As previously discussed, the Agency believes that this risk estimate is the
result of conservative assumptions.
Table 4. Summary of Dietary Exposure and Risk from Directly Treated Crops,
Irrigated Crops, and Drinking Water
Population Subgroup
General U.S. Population
All Infants (<1 year old)
Children 1-2 years old
Dietary Exposure
mg/kg/day
0.002297
0.007234
0.003574
% cPAD
(Food + Water)
33
103
51
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6. Residential Risk
Endothall products may be used in residential settings to control aquatic weeds
and algae in ponds and garden pools. Therefore, homeowners may potentially be
exposed to endothall by applying home-use formulations. In addition, there is also a
potential for exposure to adults and children from incidental oral and dermal exposure
during recreational activities in public waters treated with endothall. As a result, risk
assessments were completed for both residential handlers and post-application scenarios.
Residential risks are measured by a margin of exposure (MOE), which determines how
close the exposure comes to a No Observed Adverse Effect Level (NOAEL) taken from
animal studies. For residential risk from endothall, Margins of Exposure (MOEs) that are
greater than or equal to 100 are below EPA's level of concern for short-term residential
exposures.
Residential applications are only expected to occur over short-periods of time.
Therefore, intermediate-term and long-term residential exposure assessments were not
conducted. The anticipated use patterns that could potentially lead to residential handler
exposure are: (1) loading/applying granular formulations with a belly grinder; and (2)
applying granular formulations by hand.
The exposure pathway of concern for residential handlers is short-term inhalation.
The short-term inhalation NOAEL is 9.4 mg/kg/day based on decreased pup body weight.
This endpoint is taken from the two-generation rat reproduction study. Short-term
inhalation MOEs for loading/applying granular formulations with a belly grinder range
from 190 to 830. For handlers applying granular formulations by hand, the short-term
inhalation MOE is 2700. Therefore, residential handler risks are below the Agency's level
of concern.
For residential post-application exposures, exposures on the day of application
after an application to a public water body are of the greatest concern. The Agency
identified incidental oral exposure (from swallowing water while swimming) and the
potential for dermal irritation while swimming as possible post-application exposure
scenarios. The Agency conducted an assessment, using the SWIM modeling program, to
assess incidental exposures. Risks were calculated using MOEs, where an MOE greater
than or equal to 100 is below EPA's level of concern. The incidental oral endpoint for
short-term exposure of 9.4 mg/kg/day was selected from a two-generation rat
reproduction study (in which lesions in the gastric epithelium were observed). MOEs
calculated for both children (ages 6-10) and adults are below the Agency's level of
concern for incidental oral (280 and 900, respectively). The expected exposure to
swimmers from the dermal route would be extremely low (the highest application rate
results in a water concentration of 5 ppm) and would not likely result in any irritation to
the skin. Currently, several Special Local Needs (SLN) labels have swimming
restrictions that prohibit access to waters following commercial applications.
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7. Aggregate Risk
(For a complete discussion, see Section 7.0 of the Endothall: HED Chapter of the
Reregi strati on Eligibility Decision Document, Corrected Following Public Comments,
dated September 30, 2005.)
Aggregate exposure to a pesticide combines exposure from food, drinking water,
and, if applicable, residential exposure. For endothall, aggregate risk was measured as a
margin of exposure. MOEs for short-term residential exposures above or equal to the
target level (100) are not of concern to the Agency. In the case of endothall, residential
exposures are only expected to be episodic, or short-term. Therefore, intermediate-term
and long-term residential exposures were not assessed.
For adult short-term aggregate exposure, EPA aggregated inhalation exposure
during residential applications, oral exposure during swimming, and dietary exposure
from food and drinking water. For children (ages 6-10), EPA considered incidental oral
exposure during swimming and dietary exposure (food and drinking water). Although
infants are the most sensitive subgroup for chronic dietary concerns, the Agency did not
find it appropriate to assume infants (less than one year old) participate in swimming
activities in outdoor water bodies such as lakes and ponds. The MOEs calculated are
above the target MOE, with values of 250 for children (ages 6-10) and 310 for adults (age
50 years and older). Therefore, short-term aggregate risks are below the Agency's level
of concern.
Because EPA does not expect chronic residential exposure, chronic aggregate
risks are equal to chronic dietary risks (food plus water). As described above in Section
5, these risks are at the Agency's level of concern.
8. Occupational Risk
(For a complete discussion, see the Revised Occupational and Residential Exposure
Assessment and Recommendations for the Reregi strati on Eligibility Decision Document
for Endothall, dated August 12, 2005).
Workers can be exposed to a pesticide while mixing, loading, or applying a
pesticide, and when entering a treated site. Handler and worker risks are measured by a
margin of exposure (MOE), which determines how close the occupational exposure
comes to a No Observed Adverse Effect Level (NOAEL) taken from animal studies. The
Agency initially calculates the handler risks using the least protective measures. This is
called the baseline assessment, and assumes an individual's normal work clothing (e.g,
long sleeve shirt and long pants), no gloves, and no respirator. If there is a concern at this
level, the Agency considers the use of protective measures (e.g., personal protective
equipment and engineering controls) to lower the risk. Personal protective equipment
(PPE) can include an additional layer of clothing, chemical-resistant gloves, and a
respirator. Common examples of engineering controls include: enclosed tractor cabs,
closed loading systems, and water-soluble packaging.
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a. Occupational Handler Summary
The Agency has determined that workers may be exposed to endothall while
mixing, loading, applying, and flagging for aerial applications. In the absence of
chemical-specific monitoring data for endothall, exposure analyses were performed using
the Pesticide Handlers Exposure Database (PHED). The MOEs for occupational
exposures were calculated for short-term and intermediate-term inhalation exposures for
terrestrial, aquatic, and cooling tower applications. For the short-term inhalation
exposure scenario the NOAEL is 9.4 mg/kg/day. This endpoint is based on decreased
pup body weight. For the intermediate-term inhalation exposure scenario the LOAEL is
2 mg/kg/day based on proliferative lesions of the gastric epithelium. Both endpoints for
the inhalation exposure scenarios are taken from the two-generation oral rat reproduction
study. Toxicity from dermal exposures was not assessed because a dermal endpoint was
not established for systemic effects. End-use product labels will address protection for
workers regarding dermal exposure. For occupational risks, short-term MOEs that are
greater than 100 and intermediate-term MOEs that are greater than 300 do not exceed the
Agency's level of concern. The level of concern for short and intermediate-term
exposures are based on 10X to account for interspecies extrapolation to humans from
animal test species and 10X to account for intraspecies sensitivity. For intermediate-term
exposures, an additional 3X is applied to account for the lack of a NOAEL.
i. Terrestrial Applications
All risks calculated for short-term inhalation exposure to mixers, loaders, and
applicators are below the Agency's level of concern (MOEs range from 390 to 38,000)
when wearing baseline attire. For intermediate-term inhalation exposure to mixers,
loaders, and applicators, all risks are below the Agency's level of concern (MOEs range
from 500 to 8,100 with baseline attire) with the exception of mixing and loading liquids
for aerial applications (MOEs range from 83-290 with baseline attire).
ii. Aquatic Applications
In the absence of specific occupational exposure data for aquatic use scenarios,
surrogate exposure scenarios were used to assess certain occupational scenarios. To
assess exposure from mixing, loading, and applying liquid formulations for applications
using boat-mounted spray equipment, the exposure scenario for mixing and loading
liquids for ground boom equipment was used. To assess exposure from mixing and
loading concentrate to direct metering/subsurface application equipment, the mixing and
loading scenario for mixing and loading liquid formulations was used. To assess
exposure from mixing, loading, and applying concentrate liquid formulations with a
handgun sprayer, the lawn care operator (LCO) exposure information from the Outdoor
Residential Exposure Task Force (ORETF) was used. Finally, to assess exposure from
loading and applying granular formulations, the open loading granular application
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scenario was used from the Pesticide Handler Exposure Database (PHED). For aquatic
exposures, MOEs were calculated using an 80% (PF5) respirator. Current labels require
workers to wear this type of protection.
All risks for short-term exposures from mixing, loading, and applying liquid
formulations are below the Agency's level of concern when workers wear an 80% (PF5)
respirator (NIOSH TC-21C) (MOEs range from 1150 to 130,000). All risks for
intermediate-term exposures from mixing, loading, and applying liquid formulations are
below the Agency's level of concern when workers wear an 80% (PF5) respirator
(NIOSH TC-21C) (MOEs range from 400 to 275,000) with the exception of mixing and
loading liquids for ground-spray type applications at high rates (MOE = 250). However,
although the MOE for this scenario does not reach the target of 300, it is unlikely that
typical applications will result in a risk to workers. For example, as part of this RED, the
Agency is requiring aquatic labels to specify that applications at the highest rate are for
spot treatments only. The exposure assessment for mixing and loading liquids assumed a
treatment area of 30 acres. In addition, intermediate-term exposure assessments assume
more than 30 days of exposure. It is unlikely that applications to large areas at high rates
will be conducted for that length of time. As a result of these assumptions and the
mitigation measures set forth in this RED, the Agency believes that the 80% respirator
will adequately protect workers for the above scenarios.
All risks for short-term exposures from loading and applying granular
formulations are below the Agency's level of concern (MOEs range from 208 to 860 with
baseline attire). For intermediate-term exposure from loading and applying granular
formulations, risks are of concern to the Agency (MOEs range from 220-240 with an
80% (PF5) respirator).
iii. Cooling Tower (Biocide) Applications
Occupational exposures were assessed for applications of endothall to cooling
towers to control mollusks and algae. Labels indicate that endothall should be
continuously fed into cooling tower waters for 6 to 144 hours. Although a continuous
feed is a daily operation, handlers treating water systems are expected to apply endothall
on a limited basis and are best represented by short-term exposure duration. All short-
term inhalation risks for cooling tower uses are below the Agency's level of concern
(MOEs range from 620 to 260,000).
b. Post-application Occupational Risk
The Agency did not assess occupational post-application risks to agricultural
workers following treatments to agricultural crops, because no systemic dermal endpoint
of concern was established. Based on acute toxicity of the active ingredient and potential
to cause severe dermal irritation, endothall is classified as a severe dermal irritant.
However, a re-entry interval of 48 hours is required for agricultural workers. Post-
application occupational exposures following endothall applications to aquatic areas is
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likely limited to persons who contact the treated water to perform tests, or persons such
as agricultural workers who may contact treated water in irrigation canals.
9. Human Incident Summary
To assess occupational and non-occupation incidents, the Agency consults several
incident reporting databases. These include: the Office of Pesticide Program Incident
Data System, Poison Control Centers, California Department of Pesticide Regulation,
National Pesticide Telecommunications Network, and the National Institute of
Occupational Safety and Health's Sentinel Event Notification System for Occupational
Risks.
Relatively few incidents of illness have been reported due to endothall. In general
reports are of irritative effects to the eye and skin. No endothall related hospitalizations
have been reported due to pesticide use. No recommendations are made based on the
very limited incident data available for endothall.
B. Ecological Risk
To estimate potential ecological risk, EPA integrates the results of exposure and
ecotoxicity studies using the risk quotient method. Risk quotients (RQs) are a screening
level for potential risk and are calculated by dividing exposure estimates by ecotoxicity
values, both acute and chronic, for various wildlife species. RQs are then compared to
levels of concern (LOCs). Table 5 lists levels of concern used in the risk assessment.
Generally, the higher the RQ, the greater the potential risk. Risk characterization
provides further information on the likelihood of adverse effects occurring by considering
the fate of the chemical in the environment, communities and species potentially at risk,
their spatial and temporal distributions, and the nature of the effects observed in studies.
RQ values are provided in parentheses for indicated exceedances in the summary below.
Table 5. Levels of Concern for Ecological Risk
If RQ > LOC value given below...
Terrestrial
Organisms
0.5
0.2
0.1
1
Aquatic
Organisms
0.5
0.1
0.05
1
Plants
1
N/A
1
N/A
Then EPA presumes...
Risk Presumption
Acute Risk- there is potential for acute risk; regulatory action
may be warranted in addition to restricted use classification
Acute Restricted Use- there is potential for acute risk, but may
be mitigated through restricted use classification
Acute Endangered Species- endangered species may be
adversely affected; regulatory action may be warranted
Chronic Risk-there is potential for chronic risk; regulatory action
may be warranted
1. Environmental Fate and Transport
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(For a complete discussion, see the Environmental Fate and Ecological Risk Assessment
of Endothall-Revised, dated April 22, 2005.)
The endothall environmental risk assessment includes an assessment of risks to
aquatic organisms from both the aquatic and terrestrial uses. Endothall is applied as
either endothall dipotassium salt or endothall N,N-dimethylalkylamine salt. After
application of either the dipotassium salt or N,N-dimethylalkylamine salt, endothall acid
is formed by degradation. The acid is the form of endothall that acts as an herbicide,
desiccant, algaecide, and biocide. The three forms of endothall have dissimilar toxicity
properties, with the endothall N,N-dimethylalkylamine salt being more toxic to aquatic
animals than the dipotassium salt. However, the dipotassium salt and endothall acid have
similar toxicity properties.
The dissociation constants of both of the endothall salts indicate that at most
environmental pH levels, the endothall salt, endothall acid, and the corresponding cation
(potassium or coco-alkylamine) will be present. After aquatic applications, endothall
salts, acid, and cation components will be found mainly in the water column. The
potassium ions that dissociate from the dipotassium salt are not of concern as a source for
additional toxicity. The persistence of endothall acid in aqueous environments is
expected to be less than ten days. In terrestrial environments, endothall acid degrades
with a half-life of approximately ten days. The half-lives of the endothall N,N-
dimethylalkylamine salt and the coco-amine have not been provided.
The environmental risk assessment is organized by risks posed by each form of
endothall. Therefore, the following sections are also organized in that manner.
2. Terrestrial Organism Risk
(For a complete discussion, see the Environmental Fate and Ecological Risk Assessment
of Endothall-Revised, dated April 22, 2005.)
a. Risks from Use of Endothall N, N-dimethylalkylamine Salt
The N,N-dimethylalkylamine salt form of endothall is the only form used
terrestrially. In terrestrial scenarios, in addition to the presence of N,N-
dimethylalkylamine salt, it is possible that the degradation products (endothall acid and
coco-alkylamine cation) will be present. As a result of exposure to these compounds
several groups of organisms are potentially at risk. Acute mammalian LOCs are
exceeded from use on all terrestrial sites (RQs range from 0.12 to 9.74). Based on
endothall acid chronic toxicity, birds feeding on grasses, broad leaf plants, and small
insects are potentially at risk from the use of N, N-dimethylalkylamine salt on potatoes,
hops, alfalfa, and clover (RQs range from 1.02 to 9.10). Chronic RQs for birds are based
on early embryonic mortality. From use on alfalfa, clover, potatoes, and hops chronic
LOCs for mammals are exceeded (RQs range from 1.04 to 3.03). Chronic RQs for
mammals are based on decreased pup body weight and death of animal within one day.
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Because endothall is a herbicide, non-target plants are potentially at risk from
drift and runoff of endothall N,N-dimethylalkylamine salt away from target use sites.
LOCs are exceeded for non-target plants caused by adjacent runoff and wetland area
runoff from applications made to potatoes, hops, alfalfa, clover, and cotton (RQs range
from 2.3 to 27.5). LOCs for acute algae toxicity are also exceeded for terrestrial use of
N, N-dimethylalkylamine salt (RQs range from 1 to 7.65).
The Agency feels that potential risks to terrestrial organisms from the N, N-
dimethylalkylamine salt may have been underestimated because terrestrial RQs were
based on toxicity data using endothall acid and endothall dipotassium salt. Available
ecotoxicity studies using the N, N-dimethyalkylamine salt indicate it is more toxic to
organisms than dipotassium salt or endothall acid. Additional data pertaining to the fate
and ecotoxicity of the N, N-dimethylalkylamine salt is being requested.
3. Aquatic Organism Risk
The RQs presented below are representative of RQs resulting from a range of
application rates for aquatic use. The rates that were used in the assessment included 0.5,
1.0, 2.5, 3, 4, and 5 ppm. A range of application rates was used in order to compare RQs
at low, average, and maximum application rates.
Although the assessment was performed using very high end label rates, typical
rates used to control algae and plants are low, 0.05-0.3 ppm and 1-3 ppm, respectively.
Therefore, RQs calculated at rates above 3 ppm are conservative expressions of risk and
represent exposure scenarios that are infrequent.
a. Risks from Use of Endothall N, N-dimethylalkylamine Salt
The N,N-dimethylalkylamine salt form of endothall is more toxic than other
forms of endothall (2 to 3 orders of magnitude) to aquatic organisms, both on an acute
and chronic basis. On an acute basis, the N,N-dimethylalkylamine salt is considered to
be highly toxic to very highly toxic to freshwater fish, moderately toxic to highly toxic to
estuarine/marine fish, and moderately toxic to very highly toxic to estuarine/marine
invertebrates. Acute LOCs are exceeded for freshwater and marine fish (RQs range from
0.6 to 119), invertebrates (RQs range from 3 to 417), vascular plants (RQs range from 2
to 7), and algae (RQs range from 217 to 2174) from all direct applications to water,
including once-through cooling tower uses. Chronic LOCs are exceeded for freshwater
fish (RQs range from 2.2 to 22.2) and invertebrates (RQs range from 133 to 1331.3) from
all direct applications to water, including once-through cooling tower uses. For
freshwater fish, chronic RQs are based on survival, and for freshwater invertebrates,
chronic RQs are based on reproduction rate.
The Environmental Incident Information System (EIIS) database has records of
two fish kills related to the use of endothall N, N-dimethylalkylamine salt. Accidental
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misuse of the biocide formulation in a Minnesota power plant cooling chamber resulted
in the deaths of thousands of green sunfish, catfish, and shiners due to the high water
temperature (92° C) at application. The second incident occurred when a 5-gallon can of
endothall N, N-dimethylalkylamine salt product spilled into a drain in California and
resulted in the death of over one thousand carp.
Terrestrial use of N,N-dimethylalkylamine salt also poses risks to aquatic
organisms from runoff and drift. Acute LOCs are exceeded for freshwater fish (RQs
range from 0.5 to 0.92), freshwater invertebrates (RQs range from 0.5 to 3.23), and algae
(RQs range from 1.04 to 7.65) from runoff.
b. Risks from Use of Endothall Dipotassium Salt
Endothall dipotassium salt is applied directly to the aquatic environment.
The Agency used the acute toxicity values for endothall dipotassium salt to calculate risk
to fish and aquatic invertebrates. On an acute basis, the dipotassium salt is considered to
be slightly toxic to practically non-toxic to freshwater fish, slightly toxic to
estuarine/marine fish, and moderately toxic to practically non-toxic to estuarine/marine
invertebrates. Aquatic non-endangered vascular plant LOCs are exceeded for acute
exposure from all direct applications to water (RQs range from 2.5 to 8). Acute LOCs
are exceeded for freshwater fish at maximum application rates (RQ = 0.55). Chronic risk
was calculated for aquatic animals using endothall acid and endothall dipotassium salt
toxicity data due to the dissociation of the dipotassium salt to endothall acid. Chronic
LOCs are minimally exceeded for freshwater fish from the highest application rate (RQ
=1) and for freshwater invertebrates from the two highest application rates (RQs range
from 1.1 to 1.4). Chronic RQs for freshwater fish are based on wet weight and length,
and chronic RQs for freshwater invertebrates are based on length and number of
offspring.
c. Risks from Endothall Acid
Although endothall acid is not directly applied to use sites, it is possible that
plants and animals may be exposed to the acid. The dissociation constants of both of the
salts indicate that at most environmental pH levels, the endothall salt, endothall acid, and
the corresponding cation (potassium or coco-alkylamine) will all be present. Endothall
acid is considered to be slightly toxic to freshwater fish, slightly toxic to practically non-
toxic to aquatic freshwater invertebrates, practically non-toxic to estuarine/marine fish,
and slightly toxic to estuarine/marine invertebrates on an acute basis. Chronic LOCs are
minimally exceeded for freshwater fish from applications at the highest rate (RQ =1),
and for freshwater invertebrates from the two highest application rates (RQs range from
1.1 to 1.4). Chronic RQs for freshwater fish are based on wet weight and length, and
chronic RQs for freshwater invertebrates are based on length and number of offspring.
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4. Risk to Endangered Species
a. Risks fro m Use of Endothall N, N-dimethylalkylamine Salt
As discussed previously, endothall N,N-dimethylalkylamine salt is used in both
aquatic and terrestrial environments. For this reason, aquatic organisms are susceptible to
exposure from aquatic applications, and both terrestrial and aquatic organisms are
susceptible to exposure from terrestrial applications. Acute threatened and endangered
species LOCs are exceeded in the screening level risk assessment for freshwater fish
(RQs range from 12 to 119), estuarine/marine fish (RQs range from .6 to 6.10),
freshwater invertebrates (RQs range from 6 to 417), estuarine/marine invertebrates (RQs
range from 3.10 to 31.10), freshwater endangered vascular plants (RQs range from 3 to
33), and freshwater algae (RQs range from 217 to 2174) from all direct applications to
water, including once-through cooling tower uses. Chronic threatened and endangered
LOCs are exceeded for freshwater fish (RQs range from 2.2 to 22.2) and invertebrates
(RQs range from 133 to 1331.3) from all direct applications to water, including once-
through cooling tower uses.
From applications of endothall N, N-dimethylalkylamine salt made to terrestrial
environments, both aquatic and terrestrial organisms are potentially exposed. Acute
threatened and endangered LOCs are exceeded in the screening level risk assessment for
freshwater fish (RQs range from 0.06 to 0.92), estuarine/marine fish (RQs =0.05),
freshwater invertebrates (RQs range from 0.05 to 3.23) and marine/estuarine
invertebrates (RQs range from 0.05 to 0.24), and algae (RQs range from 1.04 to 7.65)
from runoff. Acute threatened and endangered mammalian LOCs are also exceeded in
the screening level risk assessment for all terrestrial uses (based on endothall acid toxicity
values) (RQs range from 0.10 to 9.74). Chronic threatened and endangered species LOCs
are exceeded in the screening level risk assessment for mammals (RQs range from 1.04
to 3.03) and birds (RQs range from 1.02 to 9.10) from use on potatoes, hops, alfalfa, and
clover.
Threatened and endangered plants are potentially exposed to N, N-
dimethylalkylamine salt from drift and runoff from targeted application sites. Threatened
and endangered species LOCs for non-target vascular plants are exceeded in the
screening level risk assessment from adjacent runoff, wetland area runoff, and spray drift
associated with use on all crops (RQs range from 1.5 to 137.5).
Further, there may be potential for indirect effects to listed species in any taxa that
are dependent upon a taxa that may experience effects from the use of this pesticide.
The Agency feels that potential risks to terrestrial organisms from the N, N-
dimethylalkylamine salt may have been underestimated because RQs were based on
toxicity data using endothall acid and endothall dipotassium salt. Available ecotoxicity
studies using the N, N-dimethyalkylamine salt indicate it is more toxic to organisms than
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dipotassium salt or endothall acid. Additional data pertaining to the fate and ecotoxicity
of the N, N-dimethylalkylamine salt is being requested.
Risks to endangered species identified in the Environmental Fate and Ecological
Risk Assessment for Endothall are based solely on EPA's screening level assessment and
do not constitute "may effect" findings under the Endangered Species Act.
b. Risks from Use of Endothall Dipotassium Salt
Several threatened and endangered species level of concern exceedences in the
screening level risk assessment occur from use of endothall dipotassium salt.
Exceedences occur for acute effects to freshwater fish (RQs range from 0.05 to 0.55) and
vascular plants (RQs range from 181 to 1087) from all direct applications to water. From
applications at the highest rates (4 and 5 ppm), exceedences occur for marine/estuarine
fish (RQs range from 0.05 to 0.06), freshwater invertebrates (RQs range from 0.06 to
0.08), and marine/estuarine invertebrates (RQs range from 0.06 to 0.07). Chronic RQs
are minimally exceeded for freshwater fish (RQ = 1) and freshwater invertebrates (RQs
range from 1.1 - 1.4) at maximum application rates. Data are unavailable with which to
assess potential chronic risks to estuarine/marine species and therefore, potential risks can
not be dismissed for these taxa. Further, there may be potential for indirect effects to
listed species in any taxa that are dependent upon a taxa that may experience effects from
the use of this pesticide. These findings are based solely on EPA's screening level
assessment and do not constitute "may affect" findings under the Endangered Species
Act.
IV. Risk Management, Reregistration, and Tolerance Reassessment Decision
A. Determination or Reregistration Eligibility
Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after submission
of relevant data concerning an active ingredient, whether or not products containing the
active ingredient are eligible for reregi strati on. The Agency has previously identified and
required the submission of the generic (i.e., active ingredient-specific) data required to
support reregi strati on of products containing endothall as an active ingredient. The
Agency has completed its review of these generic data, and has determined that the data
are sufficient to support reregi strati on of all supported products containing endothall.
The Agency has completed its assessment of the dietary, occupational, drinking
water, and ecological risks associated with the use of pesticide products containing the
active ingredient endothall. Based on a review of these data and on public comments on
the Agency's assessments for the active ingredient endothall, the Agency has sufficient
information on the human health and ecological effects of endothall to make decisions as
part of the tolerance reassessment process under FFDCA and reregistration process under
FIFRA, as amended by FQPA. The Agency has determined that endothall containing
products are eligible for reregistration provided that (i) current data gaps and
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confirmatory data needs are addressed; (ii) the risk mitigation measures outlined in this
document are adopted; and (iii) label amendments are made to reflect these measures.
Label changes are summarized in Section V. Appendix A summarizes the uses of
endothall that are eligible for reregistration. Appendix B identifies generic data
requirements that the Agency reviewed as part of its determination of reregistration
eligibility of endothall, and lists the submitted studies the Agency found acceptable. Data
gaps are identified as generic data requirements that have not been satisfied with
acceptable data or data which are needed to confirm the decision presented here.
Based on its evaluation of endothall, the Agency has determined that endothall
products, unless labeled and used as specified in this document, would present risks
inconsistent with FIFRA. Accordingly, should a registrant fail to implement any of the
risk mitigation measures identified in this document, the Agency may take regulatory
action to address the risk concerns from the use of endothall. If all changes outlined in
this document are incorporated into the product labels, then all current risks for endothall
will be adequately mitigated for the purposes of this determination under FIFRA.
Additionally, once an endangered species assessment is completed, further changes to
these registrations may be necessary as explained in section IV.D.S.a of this document.
B. Public Comments and Responses
Through the Agency's public participation process, EPA worked with
stakeholders and the public to reach the regulatory decisions for endothall. During the
public comment period on the risk assessments, which closed on July 11, 2005, the
Agency received comments from the registrant, the United States Army Corps of
Engineers, endothall applicators, and concerned citizens. These comments in their
entirety are available in the public docket, http://docket.epa.gov/edkpub/index.jsp, OPP-
2005-0370. The Agency's responses to these comments are incorporated into the revised
chapters and are available in the public docket.
C. Regulatory Position
1. Food Quality Protection Act Findings
a. "Risk Cup" Determination
As part of the FQPA tolerance reassessment process, EPA assessed the risks
associated with endothall. The Agency has concluded that tolerances for endothall meet
the FQPA safety standards and that the aggregate (food, drinking water, and residential
sources) exposure is within the "risk cup". The Agency has determined that the human
health risks from these combined exposures are within acceptable levels. In reaching this
determination, EPA has considered the available information on the special sensitivity of
infants and children.
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b. Determination of Safety to U.S. Population (Including
Infants and Children)
The Agency has determined that the established tolerances for endothall, with
amendments and changes as specified in this document, meet the safety standards under
the FQPA amendments to section 408(b) (2) (D) and 408(b) (2) (c) of the FFDCA, and
that there is a reasonable certainty that no harm will result to infants, children, or the
general population or any subgroup from the use of endothall. The safety determination
for infants and children considers factors including toxicity, use practices, and
environmental behavior noted above for the general population, but also takes into
account the possibility of increased dietary exposure due to specific consumption patterns
of infants and children, as well as the possibility of increased susceptibility to the toxic
effects of endothall residues in this population subgroup.
No special FQPA Safety Factor is necessary to protect the safety of infants and
children. In determining whether or not infants and children are particularly susceptible
to toxic effects from endothall residues, the Agency considered the completeness of the
database for developmental and reproductive effects, the nature of the effects observed,
and other information. The FQPA safety factor has been removed (i.e., reduced to IX)
for endothall based on: (1) there was no quantitative or qualitative evidence of increased
susceptibility following prenatal exposure to rats in the developmental toxicity study or
pre/postnatal exposure to rats in the 2-generation rat toxicity study, (2) there are no
concerns for residual uncertainty for prenatal toxicity in the available developmental
study, or the 2-generation rat toxicity study, and (3) there are no residual uncertainties for
exposure.
c. Endocrine Disrupter Effects
EPA is required under the FFDCA, as amended by FQPA, to develop a screening
program to determine whether certain substances (including all pesticide active and other
ingredients) "may have an effect in humans that is similar to an effect produced by a
naturally occurring estrogen, or other endocrine effects as the Administrator may
designate." Following recommendations of its Endocrine Disrupter Screening and
Testing Advisory Committee (EDSTAC), EPA determined that there was a scientific
basis for including, as part of the program, the androgen and thyroid hormone systems, in
addition to the estrogen hormone system. EPA also adopted EDSTAC's recommendation
that EPA include evaluations of potential effects in wildlife. For pesticides, EPA will use
FIFRA and, to the extent that effects in wildlife may help determine whether a substance
may have an effect in humans, FFDCA authority to require the wildlife evaluations. As
the science develops and resources allow, screening for additional hormone systems may
be added to the Endocrine Disrupter Screening Program (EDSP).
When the appropriate screening and/or testing protocols being considered under
the EDSP have been developed, endothall may be subject to additional screening and/or
testing to better characterize effects related to endocrine disruption.
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d. Cumulative Risks
Risks summarized in this document are those that result only from the use of
endothall. The Food Quality Protection Act (FQPA) requires that the Agency consider
"available information" concerning the cumulative effects of a particular pesticide's
residues and "other substances that have a common mechanism of toxicity". The reason
for consideration of other substances is due to the possibility that low-level exposures to
multiple chemicals substances that cause a common toxic effect by a common toxic
mechanism could lead to the same adverse health effect as would a higher level of
exposure to any of the substances individually. Unlike other pesticides for which EPA
has followed a cumulative approach based on a common mechanism of toxicity, EPA has
not made a common mechanism of toxicity finding for endothall.
For information regarding EPA's efforts to determine which chemicals have a
common mechanism of toxicity and to evaluate the cumulative effects of such chemicals,
see the policy statements released by EPA's Office of Pesticide Programs concerning
common mechanism determinations and procedures for cumulating effects from
substances found to have a common mechanism on EPA's website at
http://www.epa.gov/pesticides/cumulative.
2. Tolerance Summary
A tolerance summary is presented below in Table 3. The Agency has determined
that the residue of concern in plants, livestock, and fish is endothall and its monomethyl
ester. The residue to be measured for tolerance enforcement is the combined residues of
endothall and its monomethyl ester.
Tolerances for residues of endothall, from use of the mono-N,N-
dimethyalkylamine salt, in/on plant commodities should be revised to be expressed in
terms of endothall per se and its monomethyl ester [40 CFR § 180.293]. Tolerances that
are currently established for residues in/ on undelinted cotton seed, hops, potato, and rice
grain and straw will not change in value. An interim tolerance was established for
residues of endothall in potable water; this tolerance will be proposed for revocation (an
MCL is in effect for 100 |ig/L). Under 40 CFR § 180.319 an interim tolerance exists for
residues of endothall in/on sugar beets; this tolerance should be made permanent once
additional data has been received and deemed acceptable. No tolerances have been
established for livestock commodities. The available ruminant and poultry metabolism
studies suggest that detectable residues of endothall are likely to be transferred to meat,
milk, poultry and eggs as a result of registered uses on feedstuffs. The registrant has been
required to conduct animal (ruminant and poultry) feeding studies in meat, milk, poultry,
and eggs in order to set appropriate tolerances. Data have been submitted to support
tolerances in fmfish, catfish, and shellfish. This action is not incorporated into this
document and will be addressed in a separate action.
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A gas chromatography method with microcoulometric nitrogen detection is listed
as Method I in the Pesticide Analytical Manual (PAM, Volume II) for the determination
of endothall residues in/on crop commodities. An improved high performance liquid
chromotography-mass selective detector (HPLC-MSD) method has been submitted as a
confirmatory enforcement method for plants and fish. Data collection and regulatory
analytical methods for animal commodities are currently not available and are required
for reregi strati on.
The submitted magnitude of the residue studies for alfalfa seed, cottonseed, and
potatoes have been reviewed and were deemed inadequate to satisfy reregi strati on
requirements. The submitted data for hops supports the national Section 3 labels, but
does not support the Section 24(c) Special Local Need uses because a different pre-
harvest interval was used. The submitted residue data for irrigated cabbage, celery,
grapefruit, pepper, and turnip have been deemed inadequate because the water treatment
rate was less than the maximum label rate. The submitted confined rotational crop study
was deemed inadequate because the test substance was applied at a rate less than the
maximum registered seasonal rate for crops which can be rotated.
The submitted processing studies on cotton and potatoes are acceptable, and the
results of these studies show that endothall does not concentrate in the processed
fractions of cotton and potatoes. A sugar beet processing study was submitted and was
deemed inadequate.
Although additional data are required to confirm the existing tolerance level in/on
the following commodities, the Agency has no dietary, drinking water or residential risk
concerns associated with these tolerances and considers them reassessed: cotton
(undelinted seed), hop, potato, rice (grain), rice (straw), and sugar beet.
Endothall is registered for use on aquatic areas such as irrigation and drainage
canals, and the treated water from these sites may be diverted to irrigate food or feed
crops. The Agency requested the registrant to submit studies to address residues on
irrigated crops. In response, the registrant submitted limited studies that investigated the
magnitude of endothall residues on irrigated crops such as cabbage, celery, grapefruit,
peppers, and turnips. These studies were not conducted using maximum labeled
application rates or label-specified application intervals. Additional data on irrigated
crops are required for reregi strati on. For the purpose of continuity, the Agency is
requiring that the submitted studies be redone using current label instructions.
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a. Tolerances Currently Listed and Tolerance Reassessment
Table 6. Tolerance Table
Commodity
Current
Tolerance
(ppm)
Reassessed
Tolerance
(ppm)
Comments
Tolerances Listed Under 40 CFR § 180.293 (a)(l)
Cotton,
Undelinted Seed
Hop
Potato
Rice, Grain
Rice, Straw
0.1
0.1
0.1
0.05 (N)
0.05 (N)
To Be
Determined
(TBD)
TBD
TBD
TBD
TBD
Additional data are required. Data submitted
by the registrant was performed in the wrong
geographic area, used incorrect rates, the
wrong pre -harvest interval, and the cotton
was delinted prior to analysis.
Additional data are required. Submitted data
does not support 24(c) registrations. Change
commodity name to Hop, Dried Cones
Additional data are required. Data submitted
by the registrant used incorrect application
rate.
Although there are presently no registered
uses on rice, the Agency recommends the
retention of these tolerances until the
registrant has submitted the requested
irrigation crop data that should include data
for rice commodities.
Tolerance Listed Under 40 CFR § 180.293 (a)(2)
Potable Water
0.2
Revoke
Tolerance
EPA's Office of Pesticide Programs no longer
establishes tolerances in drinking water.
EPA's Office of Water has established an
MCL for endothall at 0. 1 ppm
Tolerance Listed Under 40 CFR § 180.319
Beet, Sugar
0.2
TBD
Additional data are required. Although there
are presently no registered uses on sugar
beets, the Agency recommends the retention
of the interim tolerance until the registrant
has submitted the requested irrigation crop
data. Residue data must include data for both
sugar beet root and tops. Change commodity
name to Beet, sugar, root.
Tolerances to be Proposed Under 40 CFR § 180.293
Cotton Gin
Byproducts
Animal
Commodities
Processed
Commodities
NA
NA
NA
TBD
TBD
TBD
A tolerance for cotton gin byproducts will
need to be proposed when requesting cotton
field trials and have been received and
evaluated.
Tolerances for animal commodities will need
to be proposed when the requested cotton
field trials have been received and evaluated.
Tolerances for processed commodities may
be needed if the levels of endothall residues
expected in processed commodities are found
to be significantly higher than the raw
agricultural commodities.
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Commodity
Fish and Shellfish
Current
Tolerance
(ppm)
NA
Reassessed
Tolerance
(ppm)
TBD
Comments
Tolerances that have been proposed for fish
and shellfish may become acceptable after
the appropriate stability data and
independently validated enforcement method
have been submitted.
NOTE: The Agency has no dietary, drinking water, or residential risk concerns associated with these
tolerances and consider them reassessed at the current tolerance level. The "TBD" designation is used,
however, to convey that the Agency expects that the data required in the DCI that will be issued as a result
of this RED will confirm that conclusion.
D. Regulatory Rationale
The Agency has determined that endothall is eligible for reregi strati on provided
that additional required data are submitted to confirm this decision that the risk mitigation
measures outlined in this document are adopted, and label amendments are made to
reflect these measures. This decision considers the risk assessments conducted by the
Agency and the significance of the use of endothall.
The following is a summary of the rationale for managing risks associated with
the use of endothall. Where labeling revisions are warranted, specific language is set
forth in the summary tables in Section V of this document.
1. Human Health Risk Management
a. Dietary Risk Mitigation (food and drinking water)
As discussed in sections III.A.4 and 5, chronic dietary risks (food and drinking
water) do not exceed the Agency's level of concern, although drinking water risk for
infants less than one year old is at the level of concern. The Agency believes that this
risk estimate is the result of conservative assumptions used in the risk assessment.
However, to ensure that dietary (food and drinking water) risks are below the Agency's
level of concern, drinking water intake setbacks will be added to endothall labels for
aquatic uses. The following language will be added to aquatic use labels:
"Drinking Water (Potable Water)
• Consult with appropriate state or local water authorities before applying this
product to public waters. State or local agencies may require permits. The
drinking water (potable water) restrictions on this label are to ensure that
consumption of water by the public is allowed only when the concentration of
endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1
ppm. Applicators should consider the unique characteristics of the treated waters
to assure that endothall concentrations in potable drinking water do not exceed 0.1
ppm at the time of consumption.
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• For applications of endothall, the drinking water setback distance from
functioning potable water intakes is greater than or equal to 600 feet.
• Note: Existing potable water intakes that are no longer in use, such as those
replaced by a connection to a municipal water system or a potable water well, are
not considered to be functioning potable water intakes.
• Drinking water setbacks distances do not apply to terrestrial applications of
endothall adjacent to water bodies with potable water intakes."
b. Occupational Risk Mitigation
As discussed in Section III.A.S.a, most occupational exposure scenarios are below
the Agency's level of concern. However, some mitigation is required to protect workers
in scenarios the Agency has indicated might result in a risk to workers. To protect
workers mixing and loading liquid formulations for aerial applications to terrestrial sites,
workers are required to wear an 80% (PF5) respirator (NIOSH TC-21C). To protect
workers mixing, loading, and applying liquid formulations for aquatic applications,
workers must wear an 80% (PF5) respirator (NIOSH TC-21C). To protect workers
loading and applying granular formulations for aquatic uses, workers are required to wear
a 90% (PF10 eslastomeric half face respirator with appropriate cartridge) respirator
(NIOSH TC-23C or NIOSH TC-14G). Specific label language will include:
• During granular applications, the respirator need not be worn, provided that the
pesticide is applied in a manner (such as aerial application or subsurface release
or from the rear of a vessel that is moving into the wind) that the applicator will
have no contact with the pesticide.
• During liquid applications, the respirator need not be worn, provided that the
pesticide is applied in a manner (such as direct metering or subsurface release
from the rear of a vessel that is moving into the wind) that the applicator will have
no contact with the pesticide.
The Agency has determined that endothall is a severe dermal irritant. Label
requirements addressing dermal effects will be addressed when toxicity data is submitted
for end-use products. The Agency will require personal protective equipment based on
end-use product toxicity during product reregi strati on.
To protect workers from exposures during post-application activities, the re-entry
interval of 48 hours will remain for agricultural workers (terrestrial applications).
Because endothall is a severe skin irritant, the Agency is requiring that double
notification statements be added to labels intended for terrestrial use.
c. Residential Risk Mitigation
Although the Agency did not identify any residential use scenarios that resulted in
risk concerns, the following statement will be put on labels addressing residential uses:
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"Consult local and state fish and game agency and water control authorities before
applying this product. Permits may be required to treat such water."
2. Environmental Risk Management
To address risks to aquatic organisms, additional directions for use and use
restrictions will be added to product labels to reduce potential risks. Specific language
and restrictions are different for the dipotassium salt and the N, N-dimethylalkylamine
salt, and are discussed below.
a. Dipotassium Salt
The Agency is requiring that labels for the dipotassium salt form of endothall
specify different rates for different size applications. This language will specify that for
large treatment areas, lower rates of endothall dipotassium salt must be used. For
smaller, spot treatments, higher rates of endothall dipotassium salt can be used. For
example, to treat infestations of Coontail, large areas can be treated with rates of 1-2 ppm
and small areas can be treated using higher rates (2-3 ppm). Specific language will
include:
"Only use higher rates (see above example) when making treatments to small
areas with an increased potential for rapid dilution or when making long and narrow
applications such as for boat lanes or shoreline treatments where dilution may reduce the
exposure of plants and the herbicide."
"Use the lower rates (see above example) for large contiguous treatment blocks,
or in protected areas such as coves where reduced water movement will not result in
rapid dilution of the herbicide from the target treatment area or when treating entire lakes
or ponds."
b. N, N-dimethylalkylamine Salt
The Agency is requiring that products used in lakes, ponds, streams, and other
bodies of water are limited to applications to control algae, Hygrophila, Vallisneria,
Hydrilla, Cabomba, bur weed, Elodea canadensis and Brazilian elodea. The following
plants are to be removed from endothall N, N-dimethylalkylamine labels: Coontail,
Milfoil, Naiad (Najas spp.), Pondweed (Potamogeton spp.), Water Stargrass, and
Zannichellia.
3. Significance of Endothall Use
Endothall is an important part of aquatic weed and algae management. Currently
there are not many aquatic herbicide alternatives available. Although endothall
potentially poses risks to non-target plants and aquatic organisms, typical use patterns
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and additional label requirements required in this RED will reduce exposure to non-target
organisms while maintaining its most important uses.
The N, N-dimethylalkylamine salt is an important tool for controlling algae and
aquatic weeds that cannot be controlled with endothall dipotassium salt. Typical rates
used to control algae are low (0.05-0.3 ppm). In addition, RQs were calculated using a
range of rates from 0.5 to 5 ppm. Therefore, RQs that were calculated using the lowest
rate of 0.5 ppm potentially overestimates risk. When algae are dense, and a higher rate is
needed, labels require that application areas are limited to no more than 10% of the water
body. Further, when algae are dense, oxygen levels in the water are low. When
conditions such as this exist, fish generally are not present and will not likely be exposed
to high application rates. In addition, as required mitigation in this RED, the N, N-
dimethylalkylamine salt will only be used on a select set of vascular plants (Hygrophila,
Vallisneria, Hydrilla, Cabomba, bur weed, Elodea Canademis and Brazilian elodea).
Previous labels allowed use on Coontail, Milfoil, Naiad (Najas spp.), Pondweed
(Potamogeton spp.), Water Stargrass, and Zannichellia. Current labels warn of toxicity to
fish and aquatic organisms and do not recommend applications above 0.3ppm where fish
are important resources. Another important aspect of N, N-dimethylalkylamine salt use
is that commercial applicators are required to apply rates above 0.3 ppm and must get the
appropriate state permitting to make an application.
Endothall dipotassium salt is an important part of aquatic weed management and
controlling submerged aquatic vegetation. Although use of endothall dipotassium salt
poses risks to non-target plants and aquatic organisms, typical use patterns will minimize
exposure to non-target organisms. For example, higher rates of the dipotassium salt are
used only for spot treatments in small areas where dense weeds are problematic. Large
areas that require weed control with the dipotassium salt are treated with lower rates and
entire bodies of water are not typically treated at one time. Similar to the N, N-
dimethylalkylamine salt, proper permitting and approval is required.
In addition to the importance of aquatic uses of endothall, the terrestrial use of N,
N-dimethylalkylamine salt is an important desiccant. The terrestrial use of N, N-
dimethylalkylamine salt is minimal. Applications of endothall as a desiccant are reserved
for sites where use of other desiccants poses risks to adjacent fields. Additionally,
terrestrial application rates of endothall N, N-dimethylalkylamine salt are very low.
Together, the minimal use and low application rates minimize risks to terrestrial
organisms.
4. Other Labeling Requirements
In order to be eligible for reregistration, endothall use and safety information will
be included in the labeling of all end-use products containing endothall. For the specific
labeling statements and a list of outstanding data, refer to Section V of this RED
document.
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5. Threatened and Endangered Species Considerations
a. The Endangered Species Program
The Agency has developed the Endangered Species Protection Program to
identify pesticides whose use may cause adverse impacts on threatened and endangered
species, and to implement mitigation measures that address these impacts. The
Endangered Species Act requires federal agencies to ensure that their actions are not
likely to jeopardize listed species or adversely modify designated critical habitat. To
analyze the potential of registered pesticide uses that may affect any particular species,
EPA uses basic toxicity and exposure data developed for the REDs and then considers
ecological parameters, pesticide use information, geographic relationship between
specific pesticide uses and species locations, and biological requirements and behavioral
aspects of the particular species. When conducted, this species-specific analysis will also
consider the risk mitigation measures that are being implemented as a result of this RED.
Following this future species-specific analysis, a determination that there is a
likelihood of potential effects to a listed species may result in limitations on use of the
pesticide, other measures to mitigate any potential effects, or consultations with the Fish
and Wildlife Service and/or the National Marine Fisheries as appropriate. If the Agency
determines use of endothall "may effect" listed species or their designated critical habitat,
EPA will employ the provisions in the Services regulations (50 CFR Part 402). Until a
species specific analysis is completed, the risk mitigation measures being implemented
through this RED will reduce the likelihood that endangered and threatened species may
be exposed to endothall at levels of concern. EPA is not requiring specific endothall
label language at the present time relative to threatened and endangered species. If, in the
future, specific measures are necessary for the protection of listed species, the Agency
will implement them through the Endangered Species Program.
b. General Risk Mitigation
Endothall end-use products (EUPs) may also contain other registered pesticides.
Although the Agency is not proposing any mitigation measures for products containing
endothall specific to federally listed threatened and endangered species, the Agency
needs to address potential risks from other end-use products. Therefore, the Agency
requires that users adopt all threatened and endangered species risk mitigation measures
for all active ingredients in the product. If a product contains multiple active ingredients
with conflicting threatened and endangered species risk mitigation measures, the more
stringent measure(s) must be adopted.
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V. What Registrants Need to Do
The Agency has determined that endothall is eligible for reregi strati on provided
that: (i) additional data that the Agency intends to require to confirm this decision; (ii) the
risk mitigation measures outlined in this document are adopted; and (iii) label
amendments are made to reflect these measures. To implement the risk mitigation
measures, the registrants must amend their product labeling to incorporate the label
statements set forth in the Label Changes Summary Table in Section B below (Table 6).
The additional data requirements that the Agency intends to obtain will include, among
other things, submission of the following:
For endothall technical grade active ingredient products, the registrant needs to
submit the following items:
Within 90 days from the receipt of the generic data call in (DCI):
1. Completed response forms to the generic DCI (i.e., DCI response form and
requirement status and registrant's response form); and
2. Submit any time extension and/or waiver requests with a full written
justification.
Within the time limit specified in the generic DCI:
1. Cite any existing generic data which address data requirements or submit new
generic data responding to the DCI.
Please contact Anne Overstreet at (703) 308-8068 with questions regarding generic
registration.
By US Mail: By express or courier service:
Document Processing Desk (DCI/SRRD) Document Processing Desk (DCI/SRRD)
Anne Overstreet Anne Overstreet
US EPA (7508C) Office of Pesticide Programs (7508C)
1200 Pennsylvania Ave., NW Room 266A, Crystal Mall 2
Washington, DC 20460 1801 S. Bell Street
Arlington, VA 22202
For end-use products containing the active ingredient endothall, the registrant
needs to submit the following items for each product:
Within 90 days from the receipt of the product-specific data call-in (PDCI):
33
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1. Completed response forms to the PDCI (i.e., PDCI response form and
requirement status and registrant's response form); and
2. Submit any time extensions and/or waiver requests with a full written
justification.
Within eight months from the receipt of the PDCI:
1. Two copies of the confidential statement of formula (EPA Form 8570-4);
2. A completed original application for reregi strati on (EPA Form 8570-1).
Indicate on the form that it is an "application for reregistration";
3. Five copies of the draft labeling incorporating all the label amendments
outlined in Table 7 of this document;
4. A completed form certifying compliance with data compensation requirements
(EPA Form 8570-34);
5. If applicable, a completed form certifying compliance with cost share offer
requirements (EPA Form 8570-32); and
6. The product-specific data responding to the PDCI.
Please contact Venus Eagle at (703) 308-8045 with questions regarding product
reregistration and/or the PDCI. All materials in response to the PDCI should be
addressed as follows:
By US Mail: By express or courier service:
Document Processing Desk Document Processing Desk
(PDCI/SRRD/PRB) (PDCI/SRRD/PRB)
Venus Eagle Venus Eagle
US EPA (7508C) Office of Pesticide Programs (7508C)
1200 Pennsylvania Ave., NW Room 266A, Crystal Mall 2
Washington, DC 20460 1801 S. Bell Street
Arlington, VA 22202
A. Manufacturing Use Products
1. Additional Generic Data Requirements
The generic database supporting the reregistration of endothall has been reviewed
and determined to be substantially complete. However, the following additional data
34
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requirements have been identified by the Agency as confirmatory and are included in the
generic DCI for this RED.
Table 7. Confirmatory Data Requirements for Reregistration
Guideline Number
71-4
(850.2300)
72-4C
(850.1400)
72-4B
(850.1350)
72-5
(850.1500)
850.1735
850.1740
Special Study
Special Study
83-3B
(870.3700B)
82-4
(870.3465)
171-4C&D
(860.1340)
171-4D
(860.1340)
171-4
(860.1340)
171-4E
(860.1380)
171-4J
(860.1480)
171-4H
(860.1400)
171-4L
(860.1520)
171-4L
(860.1520)
165-1
(860.1850)
Study/Requirements
Avian Chronic Reproduction study in quail or duck using N,N-dimethylalkylamine
salt
Estuarine/Marine Fish Early Life -Stage Study using N,N-dimethylalkylamine salt
Estuarine/Marine Invertebrate Early Life -Stage study using N,N-
dimethylalkylamine salt
Fish Life -Cycle study using N,N-dimethylalkylamine salt
Acute Freshwater Sediment study using N,N-dimethylalkylamine salt
Acute Estuarine/Marine Sediment study using N,N-dimethylalkylamine salt
Chronic Estuarine/Marine Sediment Testing using N,N-dimethylalkylamine salt
65 -day Test in Chironomus tentans using N,N-dimethylalkylamine salt
Developmental/Teratology in Non-rodent (rabbit) study
28-day Inhalation study
Residue Analytical Method-Plants and Animals. Radbvalidation data needed to
determine whether the current enforcement methods for plants and the required
enforcement method(s) for animals can adequately extract and convert aged
residues of the monomethyl ester to endothall.
Data collection and regulatory analytical methods are needed for the determination
of endothall, per se, in animal commodities
Submission of analytical reference standards for dipotassium and mono-N,N-
dimethylalkylamine salts of endothall
Storage stability data for processed plant commodities, animal commodities, and
fish
Livestock (ruminant and poultry) feeding studies
Magnitude of residues in irrigated crops
Magnitude of residue studies in potato, alfalfa seed, cotton seed, and cotton gin
products. Magnitude of residue studies in raw agricultural commodities of sugar
beet and rice if the registrant is supporting these uses
Processing studies on apples, field corn, grapes, orange, rice, sorghum, soybeans,
sugar beet, tomato, and wheat to cover irrigation uses
A confined, rotational crop study after treatment at the proper maximum labeled
rate for irrigation water
2. Labeling for Technical and Manufacturing Use Products
To ensure compliance with FIFRA, technical and manufacturing use products
(MP) labeling should be revised to comply with all current EPA regulations, PR Notices
and applicable policies. The technical and MP labeling should bear the labeling
contained in Tables 8 and 9, Label Changes Summary Table.
35
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B. End-Use products
1. Additional Product-Specific Data Requirements
Section 4(g) (2) (B) of FIFRA calls for the Agency to obtain any needed product-
specific data regarding the pesticides after a determination of eligibility has been made.
The registrant must review previous data submissions to ensure they meet current EPA
acceptance criteria and if not, commit to conduct new studies. If a registrant believes that
previously submitted data meet current testing standards, then the study MRID numbers
should be cited according to the instructions in the Requirement Status and Registrations
Response Form provided for each product.
A product-specific data call-in, outlining specific data requirements, accompanies
this RED.
2. Labeling for End-Use Products
Labeling changes are necessary to implement measures outlined in Section IV
above. Specific language to incorporate these changes is specified in the Label Changes
Summary Table below.
Existing stocks time frames will be established case by case, depending on the
number of products involved, the number of label changes, and other factors. Refer to
"Existing Stocks of Pesticide Products; Statement of Policy," Federal Register, Volume
56, No. 123, June 26, 1991.
a. Label Changes Summary Table
In order to be eligible for reregi strati on, amend all product labels to incorporate
the risk mitigation measures outlined in Section IV The following table describes how
language on the labels should be amended.
36
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Table 8. Summary of Required Labeling Changes for Products Registered for Aquatic Uses Only of Endothall
Description | Required Labeling Language | Placement on Label
Manufacturing-Use Products
Required on all Manufacturing
Use Products
" Only for formulation into an herbicide for the following use(s) [fill blank only with those
uses that are being supported by the MP registrants]."
Directions for Use
One of these statements may be
added to allow reformulation of
the product for a specific use or
all additional uses supported by
a formulator or user group.
AThis product may be used to formulate products for specific use(s) not listed on the MP
label if the formulator, user group, or grower has complied with U.S. EPA submission
requirements regarding support of such use(s).@
AThis product may be used to formulate products for any additional use(s) not listed on the
MP label if the formulator, user group, or grower has complied with U.S. EPA submission
requirements regarding support of such use(s).@
Directions for Use
Environmental Hazards
Statements Required by the
RED and Agency Label
Policies
AThis pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent
containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless
in accordance with the requirements of a National Pollutant Discharge Eliminations System
(NPDES) permit and the permitting authority has been notified in writing prior to
discharge. Do not discharge effluent containing this product to sewer systems without
previously notifying the local sewage treatment plant authority. For guidance, contact your
State Water Board or Regional Office of the Environmental Protection Agency .9
Directions for Use
End-Use Products Intended of Occupational Use
Note the following information when preparing labeling for all end-use products:
For sole-active -ingredient end-use products that contain endothall, the product label must
be revised to adopt the handler personal protective equipment (PPE)/engineering control
requirements set forth in this section. Any conflicting PPE requirements on the current
label must be removed.
For multi-active -ingredient end-use products that contain endothall, the handler
PPE/engineering control requirements set forth in this section must be compared with the
requirements on the current label, and the more protective language must be retained. For
guidance on which requirements are considered to be more protective, see PR Notice 93 -7.
PPE that is established on the basis of Acute Toxicity testing with end-use products must
be compared with the active ingredient PPE specified below in this document. The more
protective PPE must be placed in the product labeling. For example, the Handler PPE in
this RED does not require protective eyewear which may be required by the Acute Toxicity
37
-------
Description
Required Labeling Language
Placement on Label
testing for the end-use product. For guidance on which PPE is considered more protective,
see PE Notice 93-7.
Handler PPE Requirements for
Liquid Formulations for
Aquatic Applications
"Mixers, loaders, applicators, and other handlers must wear:
-long-sleeve shirt,
-long pants,
-shoes and socks, and
-a NIOSH-approved respirator with a dust/mist filter with MSHNA/NIOSH approval
number prefix TC-21C or any N, R, P, or He filter.
Exception: during application, the respirator need not be worn, provided that the pesticide
is applied in a manner (such as direct metering or subsurface release from the rear of a
vessel that is moving into the wind) that the applicator will have no contact with the
pesticide.
See engineering controls for additional options."
Precautionary Statements:
Hazards to Humans and
Domestic Animals
Handler PPE Requirements for
Granular Formulations for
Aquatic Applications
"Mixers, loaders, applicators, and other handlers must wear:
-long-sleeve shirt,
-long pants,
-shoes and socks, and
-a NIOSH-approved half- or full-face respirator with a cartridge approved for dusts and
mists or a canister approved for dusts and mists or a cartridge with any N*, R, P, or He
filter. Note: the quarter-face cup-style respirator does not meet this requirement.
Exception: during application, the respirator need not be worn, provided that the pesticide
is applied in a manner (such as aerial application or subsurface release or from the rear of a
vessel that is moving into the wind) that the applicator will have no contact with the
pesticide.
See optional engineering controls for additional instructions."
*Instruction to registrant: Drop the "N" type pre-filter from the response statement if the
pesticide product contains, or is used with, oil.
Engineering Controls: Liquid
Formulations Only
Engineering Control Statement for Optional Use (WPS only)
"Engineering Controls:
Precautionary Statements:
Hazards to Humans and
Domestic Animals
(Immediately following PPE
38
-------
Description
Required Labeling Language
Placement on Label
"When mixers and loaders use a closed system designed by the manufacturer to enclose the
pesticide to prevent it from contacting handlers or other people AND the system is
functioning properly and is used and maintained in accordance with the manufacturers
written operating instructions, the handlers need not wear a respirator, provided the
required respirator is immediately available for use in an emergency such as a spill or
equipment breakdown."
and User Safety Requirements)
Engineering Controls: Enclosed
Cockpit for Granular Aerial
Applicators
"Engineering Controls:
Pilots must used an enclosed cockpit that meets the requirements listed in the WPS for
agricultural pesticides [40 CFR 170.240(d) (6)."
Precautionary Statements:
Hazards to Humans and
Domestic Animals
(Immediately following PPE
and User Safety Requirements)
User Safety Requirements
AFollow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions
for washables exist, use detergent and hot water. Keep and wash PPE separately from
other laundry.®
ADiscard clothing or other absorbent materials that have been drenched or heavily
contaminated with this products concentrate. Do not reuse them. ®
Precautionary Statements:
Hazards to Humans and
Domestic Animals
(Immediately following PPE
and User Safety Requirements)
User Safety Recommendations
AUSER SAFETY RECOMMENDATIONS?
AUsers should wash hands before eating, drinking, chewing gum, using tobacco, or using
the toilet.®
AUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash
thoroughly and put on clean clothing.®
AUsers should remove PPE immediately after handling this product. Wash the outside of
gloves before removing. As soon as possible, wash thoroughly and change into clean
clothing.®
Precautionary Statements
under: Hazards to Humans and
Domestic Animals immediately
following Engineering Controls
(Must be placed in a box.)
Environmental Hazards
"ENVIRONMENTAL HAZARDS"
"This pesticide is toxic to fish. This pesticide is toxic to wildlife. "
"Do not contaminate water by cleaning of equipment or disposal of equipment wash
waters. Do not contaminate water, food, or feed by storage or disposal."
Precautionary Statements under
Environmental Hazards
39
-------
Description
Required Labeling Language
Placement on Label
Applications Restrictions for all
products applied as a spray
"Do not apply this product in a way that will contact workers or other persons, either
directly or through drift."
Directions for Use directly
above the Agricultural Use Box
Application Restrictions for
Aquatic Applications-Liquids
Formulations Only
"Aerial application is prohibited."
Directions for Use (near the
beginning of the section)
Other Use/Application
Restrictions
Streams, Rivers, Channeled Water: Do not contaminate water intended for irrigation or
domestic purposes. Do not use water for spraying or irrigation within 7 days after
treatment.
Swamps, Marshland, Wetlands, Stagnant Water: Do not contaminate water intended for
irrigation or domestic purposes.
Human Drinking Water Systems: Do not contaminate water intended for irrigation or
domestic purposes.
Commercial, Industrial Water Cooling Systems: Do not discharge the effluent
containing this pesticide into sewage systems without notifying the sewage treatment plant
authority (POTW). Do not discharge effluent containing this product into lakes, streams,
ponds, estuaries, oceans, or public water (NPDES license restrictions).
Directions for Use under
General Precautions and
Restrictions and/or Application
Instructions
Other Use/Application
Restrictions
Drinking Water (Potable Water)
• Consult with appropriate state or local water authorities before applying this
product to public waters. State or local agencies may require permits. The
drinking water (potable water) restrictions on this label are to ensure that
consumption of water by the public is allowed only when the concentration of
endothall is the water is less than the MCL (Maximum Contaminant Level) of 0.1
ppm. Applicators should consider the unique characteristics of the treated waters
to assure that endothall concentrations in potable drinking water do not exceed 0.1
ppm at the time of consumption.
• For applications of endothall, the drinking water setback distance from
functioning potable water intakes is greater than or equal to 600 feet.
• Note: Existing potable water intakes that are no longer in use, such as those
Directions for Use under
General Precautions and
Restrictions and/or Application
Instructions
40
-------
Description
Required Labeling Language
Placement on Label
replaced by a connection to a municipal water system or a potable water well, are
not considered to be functioning potable water intakes.
Drinking water setbacks distances do not apply to terrestrial applications of
endothall adjacent to water bodies with potable water intakes."
Additional Use/Application
Restrictions for Endothall
Dipotassium Salt
" Only use higher rates when making treatments to small areas with an increased potential
for rapid dilution or when making long and narrow applications such as for boat lanes or
shoreline treatments where dilution may reduce the exposure of plants and the herbicide."
"Use lower rates for large contiguous treatment blocks or in protected areas such
as coves where reduced water movement will not result in rapid dilution of the herbicide
from the target treatment area or when treating entire lakes or ponds."
Additional Use/Application
Restrictions for Endothall N, N-
Dimethylalkylamine Salt
All Water bodies (except Irrigation Canals/Ditches): Use of endothall N, N-
dimethylalkylamine salt is limited to algae and the following plants:
Hygrophila, Vallisneria, Hydrilla, Cabomba,
bur weed, Elodea canadensis, and Brazilian elodea.
Lakes, Ponds, Reservoirs (with human or wildlife use): Do not contaminate water
intended for irrigation or domestic purposes. Do not use water for domestic purposes until
25 days after treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment
of 0.3 ppm. Do not use treated water for animal consumption within 25 days of treatment
of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use
treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14 days for
treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use where fish are
important resources. Do not treat more than 10% of the area at one time with doses in
excess of 1 ppm,
Agricultural Drainage Systems, Drainage Systems: Do not use water for domestic
purposes until 25 days after treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days
for treatment of 0.3 ppm. Do not use treated water for animal consumption within 25 days
of treatment of 5 ppm, 14 days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm.
Do not use treated water for spraying or irrigation within 25 days of treatment of 5 ppm, 14
days for treatment of 3 ppm, and 7 days for treatment of 0.3 ppm. Do not use where fish
are important resources. Do not treat more than 10% of the area at one time with doses in
excess of 1 ppm.
41
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Table 9. Summary of Required Labeling Changes for Products Registered for Terrestrial Uses Only of Endothall
Description | Required Labeling Language | Placement on Label
Manufacturing-Use Products
Required on all Manufacturing
Use Products
"Only for formulation into an herbicide for the following use(s) [fill blank only with those
uses that are being supported by the MP registrants]."
Directions for Use
One of these statements may be
added to allow reformulation of
the product for a specific use or
all additional uses supported by
a formulator or user group.
AThis product may be used to formulate products for specific use(s) not listed on the MP
label if the formulator, user group, or grower has complied with U.S. EPA submission
requirements regarding support of such use(s).@
AThis product may be used to formulate products for any additional use(s) not listed on the
MP label if the formulator, user group, or grower has complied with U.S. EPA submission
requirements regarding support of such use(s).@
Directions for Use
Environmental Hazards
Statements Required by the
RED and Agency Label
Policies
AThis pesticide is toxic to fish and aquatic invertebrates. Do not discharge effluent
containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless
in accordance with the requirements of a National Pollutant Discharge Eliminations System
(NPDES) permit and the permitting authority has been notified in writing prior to
discharge. Do not discharge effluent containing this product to sewer systems without
previously notifying the local sewage treatment plant authority. For guidance, contact your
State Water Board or Regional Office of the Environmental Protection Agency .9
Directions for Use
End-Use Products Intended of Occupational Use
Note the following information when preparing labeling for all end-use products:
For sole-active -ingredient end-use products that contain endothall, the product label must
be revised to adopt the handler personal protective equipment (PPE)/engineering control
requirements set forth in this section. Any conflicting PPE requirements on the current
label must be removed.
For multi-active -ingredient end-use products that contain endothall, the handler
PPE/engineering control requirements set forth in this section must be compared with the
requirements on the current label, and the more protective language must be retained. For
guidance on which requirements are considered to be more protective, see PR Notice 93 -7.
PPE that is established on the basis of Acute Toxicity testing with end-use products must
be compared with the active ingredient PPE specified below in this document. The more
protective PPE must be placed in the product labeling. For example, the Handler PPE in
this RED does not require protective eyewear which may be required by the Acute Toxicity
42
-------
Description
Required Labeling Language
Placement on Label
testing for the end-use product. For guidance on which PPE is considered more protective,
see PE Notice 93-7.
Handler PPE Requirements
"Mixers, loaders, applicators, and other handlers must wear:
-long-sleeve shirt,
-long pants,
-shoes and socks."
"In addition, mixers and loaders supporting aerial applications must wear:
-NIOSH-approved respirator with a dust/mist filter with MSHNA/NIOSH approval number
prefix TC-21C or any N*, R, P, or He filter."
* Instruction to registrant: drop the "N" type pre-filter from the respirator statement if the
pesticide product contains, or is used with, oil.
"See engineering controls for additional requirements."
Precautionary Statements:
Hazards to Humans and
Domestic Animals
Engineering Controls
"Engineering Controls:
Pilots must use an enclosed cockpit that meets the requirements listed in the WPS for
agricultural pesticides [40 CFR 170.240(d)(6).
Human flagging is prohibited. Flagging to support aerial applications is limited to use of
the Global Positioning System (GPS) or mechanical flaggers.
When handlers use closed systems, enclosed cabs, or cockpits in a manner that meets the
requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40
CFR 170.240(d)(4-6), the handler PPE requirements may be reduced or modified as
specified in the WPS."
Precautionary Statements:
Hazards to Humans and
Domestic Animals
(Immediately following PPE
and User Safety Requirements)
User Safety Requirements
AFollow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions
for washables exist, use detergent and hot water. Keep and wash PPE separately from
other laundry.®
ADiscard clothing or other absorbent materials that have been drenched or heavily
Precautionary Statements:
Hazards to Humans and
Domestic Animals
(Immediately following PPE
and User Safety Requirements)
43
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Description
User Safety Recommendations
Environmental Hazards
Applications Restrictions for all
products applied as a spray
Restricted-Entry Interval for
WPS products as required by
Supplement Three of PR Notice
93-7
Early Re -Entry Personal
Protective Equipment for
Products subject to WPS as
required by Supplement Three
of PR Notice 93 -7
Double Notification Statement
Other Use/Application
Restrictions
Required Labeling Language
contaminated with this products concentrate. Do not reuse them. 9
AUSER SAFETY RECOMMENDATIONS?
AUsers should wash hands before eating, drinking, chewing gum, using tobacco, or using
the toilet.®
AUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash
thoroughly and put on clean clothing.®
AUsers should remove PPE immediately after handling this product. Wash the outside of
gloves before removing. As soon as possible, wash thoroughly and change into clean
clothing.®
"ENVIRONMENTAL HAZARDS"
"Do not apply directly to water, or to areas where water is present to intertidal areas below
the mean high water mark. This pesticide is toxic to fish. This pesticide is toxic to
wildlife. Keep out of lakes, streams, and ponds."
"Do not apply this product in a way that will contact workers or other persons, either
directly or through drift."
"Do not ender or allow worker entry into treated areas during the restricted entry interval
(REI) of 48 hours."
"PPE required for early entry to treated areas that is permitted under the WPS and that
involves contact with anything that has been treated, such as soil or water, is:
-coveralls over long sleeved shirt and long pants,
-chemical-resistant gloves made of any waterproof material,
-chemical-resistant footwear plus socks,
-protective eyewear, and
-headgear for overhead exposure.
"Notify workers of the application by warning them orally and by posting warning signs at
entrances to treated area"
" Treated crops must be harvested by mechanical means only. Do not contaminate water by
cleaning of equipment or disposal of equipment wash waters. Do not contaminate water,
Placement on Label
Precautionary Statements
under: Hazards to Humans and
Domestic Animals immediately
following Engineering Controls
(Must be placed in a box.)
Precautionary Statements under
Environmental Hazards
Directions for Use directly
above the Agricultural Use Box
Directions for Use, Agricultural
Use Requirements Box
Directions for Use, Agricultural
Use Requirements Box
Agricultural Use Requirements,
following Early Entry PPE and
REI statements
Directions for Use Associated
with Each Crop
44
-------
Description
Required Labeling Language
Placement on Label
food, or feed by storage or disposal. Do not apply through any type of irrigation system.
Do not apply where drift is likely to occur.
Alfalfa and Clover: Do not feed treated fodder and/or forage to animals being finished for
slaughter. Do not graze treated areas. Do not use seed for food, feed, or oil purposes.
Grown for seed only.
Hops: Do not feed treated fodder and/or forage to animals being finished for slaughter. 85-
day Pre-Harvest Interval (PHI)
Potato: Do not feed treated forage to animals being finished for slaughter. Do not graze
treated areas. 14-day PHI.
Cotton: 7-day PHI.
Spray Drift Label Language for
Products Applied as a Spray
through Ground Equipment
RELEASE HEIGHT:
"Apply using a nozzle height of no more than 4 feet above the ground or canopy cover."
Directions for Use under
General Precautions and
Restrictions
Spray Drift Label Language for
Products Applied as a Spray
through Airblast Equipment
" Sprays must be directed into the crop canopy."
" Outward pointing nozzles should be turned off at row ends and when spraying outer
rows."
TEMPERATURE INVERSIONS:
"If applying at wind speeds less that 3 miles per hour, the applicator must determine if a)
conditions of temperature inversion exist, or b) stable atmospheric conditions exist at or
below nozzle height. Do not make applications into areas of temperature inversions or
stable atmospheric conditions."
Directions for Use under
General Precautions and
Restrictions
Spray Drift Label Language for
Products Applied as a Spray
through Aerial Equipment
RELEASE HEIGHT:
"Do not release spray at a height greater than 14 feet above the ground or canopy."
BOOM LENGTH:
" The boom length must not exceed 70% of the wingspan or 85% of the rotor blade
diameter."
SWATH ADJUSTMENT:
"When applications are made with a cross-wind, the swath will be displaced downwind.
Directions for Use under
General Precautions and
Restrictions
45
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Description
Required Labeling Language
The applicator must compensate for this displacement at the downwind edge of the
application area by adjusting the path of the aircraft upwind. Leave at least one unsprayed
at the downwind edge of the treated field. "
Placement on Label
46
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VI. Appendices
47
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A. Table of Use Patterns for Endothall
Endothall Acid (PC 038901)
Site
Application
Timing
Alfalfa
Foliar
Clover
Foliar
Cotton
Pre -harvest
Formulation
[EPA Reg.
No.]
15.9%SC/L
[4581-206]
15.9%SC/L
[4581-206]
15.9%SC/L
[4581-284]
App. Type and
Equipment
Broadcast via
Ground or Aircraft
Broadcast via
Ground or Aircraft
Max.
Single
App.
Rate
(ae)
0.7912 Ib
ae/A
0.7912 Ib
ae/A
0.0989 Ib
ae/A
Max.
Number
Apps. at
Max.
Rate
NS
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
1-2
1-2
NS
Max.
Seasonal
Rate
(ae)
PHI, PGI,
Pre-
feeding
Interval
PHI=7
days
Use Directions and Limitations
Grown for seed only. Do not
apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not feed treated forage to dairy
animals or anima Is being finished
for slaughter. Do not graze
treated areas. Do not use seed for
food, feed or oil purposes.
Same as "Alfalfa"
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
48
-------
Site
Application
Timing
Hops
Foliar
Formulation
[EPA Reg.
No.]
15.9% SC/L
[4581-206]
App. Type and
Equipment
Ground - Basal
Spray Treatment
Max.
Single
App.
Rate
(ae)
0.9494 Ib
ae/A
Max.
Number
Apps. at
Max.
Rate
NS
Max.
Number
Apps. per
Year/Crop
Cycle
2
Max.
Seasonal
Rate
(ae)
PHI, PGI,
Pre-
feeding
Interval
PHI=85
days
Use Directions and Limitations
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of wash
waters. This product is toxic to
fish. Do not contaminate water,
food, or feed by storage or
disposal. This pesticide is toxic to
wildlife.
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not feed treated forage to dairy
animals being finished for
slaughter. Do not graze treated
areas.
49
-------
Site
Application
Timing
Potato
(White/Irish)
Foliar
Formulation
[EPA Reg.
No.]
15.9% SC/L
[OR03003600]
15. 9% SC/L
[4581-206]
App. Type and
Equipment
Broadcast via
Ground or Aircraft
Max.
Single
App.
Rate
(ae)
1 Ib ae/A
1.05491b
ae/A
Max.
Number
Apps. at
Max.
Rate
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
Max.
Seasonal
Rate
(ae)
NS
PHI, PGI,
Pre-
feeding
Interval
PHI=28
days
PHI=14
days
Use Directions and Limitations
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. This
pesticide is toxic to wildlife. Do
not graze livestock in treated
areas. Do not feed treated forage
and/or fodder to animals being
finished for slaughter.
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not feed treated forage to dairy
animals being finished for
slaughter. Do not graze treated
areas.
50
-------
Site
Application
Timing
Formulation
[EPA Reg.
No.]
App. Type and
Equipment
Max.
Single
App.
Rate
(ae)
Max.
Number
Apps. at
Max.
Rate
Max.
Number
Apps. per
Year/Crop
Cycle
Max.
Seasonal
Rate
(ae)
PHI, PGI,
Pre-
feeding
Interval
Use Directions and Limitations
Endothall Dipotassium Salt (PC 038904)
Agricultural
Drainage
Systems
When Needed
Drainage
Systems
When Needed
Human
Drinking
Water
Systems
When Needed
40.3% SC/L
[4581-204]
40.3% SC/L
[FL87000500]
40.3% SC/L
[GA95000600]
[TN94000200]
[NY98000200]
[WA96000600]
10.1% G
[FL98000300]
40.3%SC/L
[FL96001500]
Water treatment -
Surface or
Subsurface-
Injection
Equipment or
Sprayer
Surface Water
Treatment
Water treatment-
Surface - Aero sol
can, Aircraft,
Sprayer
Subsurface-
Injection
Equipment
Surface Water
Treatment-
Spreader
Water Treatment
Surface- Aerosol
can, Aircraft
Subsurface-
Injection
Equipment
22.5 Ibs
ae/mile
3 ppm (L)
57.6 Ib
ae/A
3. 564 ppm
(L)/A
57.6 Ib
ae/A
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
NS
Do not use treated water for
spraying or irrigation within 25
days after treatment. Do not
apply when drift is likely to occur.
Do not contaminate water, food,
or feed by storage or disposal.
NS
Do not contaminate water, food,
or fed by storage or disposal
Do not use treated water for
spraying or irrigation within 7
days after treatment. Do not
contaminate water, food, or feed
by storage or disposal.
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
for irrigation or domestic
purposes.
51
-------
Site
Application
Timing
Irrigation
Systems
When Needed
Lakes/Ponds/
Reservoirs
(with Human
or Wildlife
Use)
When Needed
Formulation
[EPA Reg.
No.]
40.3% SC/L
[AL85000800]
40.3% SC/L
[GA95000600
0]
[TN94000200]
[NY98000200]
40.3% SC/L
[4581-204]
40.3% SC/L
[FL87000500]
40.3% SC/L
[GA95000600]
[TN94000200]
[SC93000100]
[4581-204]
[NY98000200]
[TX99000200]
[WA96000600]
App. Type and
Equipment
Water Treatment
Water Treatment
Surface - Aerosol
can, Aircraft,
Sprayer
Subsurface-
Injection
Equipment
Surface Water
Treatment
Water Treatment
Surface-
Aerosol Can,
Aerial, Sprayer
Subsurface
Treatment
Max.
Single
App.
Rate
(ae)
1 L
57.6 Ib
ae/A
3 ppm (L)
57.6 Ib
ae/A
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
NS
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
NS
NS
Use Directions and Limitations
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
for irrigation or domestic
purposes. Do not use treated
water for spraying or irrigation
within 25 days after treatment.
Do not apply when drift is likely
to occur.
NS
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
for irrigation or domestic
purposes. Do not use treated
water for spraying or irrigation
within 25 days of treatment. Do
not apply when drift is likely to
occur.
52
-------
Site
Application
Timing
Streams/
Rivers/
Channeled
Water
When Needed
Swamps/
Marshes/
Wetlands/
Formulation
[EPA Reg.
No.]
63% G
[4581-388]
[NY99000300]
[NY99000300]
10.1% G
[4581-201]
[FL98000300
(max 3.564 Ib
ae/A)]
40.3% SC/L
[FL87000500]
40.3% SC/L
[WA96000600]
10.1% G
[FL98000300]
40.3 % SC/L
[FL87000500]
App. Type and
Equipment
Surface Water
Treatment-
Broadcast, Granule
Applicator
Surface Water
Treatment-
Spreader, Granular
Applicator
Surface Water
Treatment
Water Treatment
Surf ace- Sprayer
Subsurface-
Surface Water
Treatment
Surface Water
Treatment
Max.
Single
App.
Rate
(ae)
49.171b
ae/A
58.1041b
ae/A
3 ppm (L)
57.6 Ib
ae/A
3. 564 ppm
(ae)A
3 ppm (L)
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
NS
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
NS
NS
Use Directions and Limitations
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
for irrigation or domestic
purposes. Do not use treated
water for spraying or irrigation
within 7 days of treatment. Do
not apply when drift is likely to
occur.
Do not use treated water for
spraying or irrigation within 7
days after treatment. Do not
apply when drift is likely to occur.
Do not contaminate water, food,
or feed by storage or disposal.
NS
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
for irrigation or domestic
purposes.
Do not use treated water for
spraying or irrigation within 7
days after treatment. Do not
contaminate water, food, or feed
by storage or disposal.
Do not contaminate water, food,
or feed by storage or disposal. Do
not contaminate water intended
53
-------
Site
Application
Timing
Stagnant
Water
When Needed
Formulation
[EPA Reg.
No.]
40.3% SC/L
[WA96000600]
App. Type and
Equipment
Water Treatment
Surf ace- Sprayer
Subsurface
Max.
Single
App.
Rate
(ae)
57.6 Ib
(ae)A
Max.
Number
Apps. at
Max.
Rate
Max.
Number
Apps. per
Year/Crop
Cycle
Max.
Seasonal
Rate
(ae)
PHI, PGI,
Pre-
feeding
Interval
Use Directions and Limitations
for irrigation or domestic
purposes.
Endothall N, N-dimethylalkylamine Salt (PC 038905)
Agricultural
Drainage
Systems
Alfalfa
Foliar
53% RTU
[AL81000900]
53 % SC/L
[IN80000800]
15.9% SC/L
[CA87003100]
[NV87000800]
15. 9% SC/L
[ID87001900]
[WA87003600]
Water Treatment
Broadcast
Broadcast-Ground,
Aerial
15.12 Ib
ae/A-ft
0.2 ppm
(L)
1.05491b
ae/A
0.6593 Ib
ae/A
NS
NS
NS
NS
NS
NS
NS
NS
Apply to not more than 1 0 percent
of surface area of water.
NS
Grown for seed only. Do not use
treated seed for feed, food or oil
purposes.
54
-------
Site
Application
Timing
Alfalfa
Pre -harvest
Formulation
[EPA Reg.
No.]
53% SC/L
[4581-381]
[AZ98000900]
53% SC/L
[4581-381]
53% SC/L
[WA98002900]
[ID98001300]
[NV98000200]
[CA99000300]
App. Type and
Equipment
Ground-Spray
Aircraft -
Low Volume Spray
Aerial-Spray
Ground-Spray
Max.
Single
App.
Rate
(ae)
1.5qt/L
(1.001 Ib
ae/A for
AZ98000
9000
0.7507 Ib
ae/A
1.001 Ib
ae/A
Max.
Number
Apps. at
Max.
Rate
Max.
Number
Apps. per
Year/Crop
Cycle
Max.
Seasonal
Rate
(ae)
PHI, PGI,
Pre-
feeding
Interval
Use Directions and Limitations
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not apply
when drift is likely to occur. Do
not contaminate water by cleaning
of equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not use treated seed for feed, food
or oil purposes. Do not graze
treated areas. Do not feed forage
to dairy animals or to animals
being finished for slaughter.
Grown for seed only. Keep out of
lakes, streams, and ponds.
Grown for seed only. Do not
apply through any type of
irrigation system. Keep out of
lakes, streams, and ponds. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
55
-------
Site
Application
Timing
Clover
Foliar
Commercial/
Industrial
Water
Cooling
Systems
When Needed
Formulation
[EPA Reg.
No.]
53% SC/L
[4581-381]
53% SC/L
[4581-380]
App. Type and
Equipment
Aircraft -Low
Volume Spray
Ground-Spray
Water Treatment-
Metering Pump
Max.
Single
App.
Rate
(ae)
0.7507 Ib
ae/A
3.0-0.3
ppm
endothall
technical
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
NS
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
NS
NS
Use Directions and Limitations
not use treated seed for feed, food
or oil purposes. Do not graze
treated areas. Do not feed forage
to dairy animals or to animals
being finished for slaughter.
Do not apply through any type or
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not apply
when drift is likely to occur. Do
not contaminate water by cleaning
of equipment or disposal or
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not use treated seed for feed, food
or oil purposes. Do not graze
treated areas. Do not feed forage
to dairy animals or to animals
being finished for slaughter.
Do not discharge effluent
containing this pesticide into
sewage systems without notifying
the sewage treatment plant
authority (POTW). Do not
discharge effluent containing this
product into lakes, streams, ponds,
estuaries, oceans, or public water
56
-------
Site
Application
Timing
Cotton
Pre -harvest
Drainage
Systems
When Needed
Formulation
[EPA Reg.
No.]
15.9%SC/L
[TX81003200]
53% RTU
[AL81000900]
[FL77000100]
53% SC/L
[1448-352]
App. Type and
Equipment
Aerial or ground
Spray
Surface Treatment-
Aerial, Boat
Injection
Equipment (max
11.21bae/A-ft)
Surface Treatment-
Injection
Equipment,
Ground (Sprayer)
Max.
Single
App.
Rate
(ae)
0.1319 Ib
ae/A
15.12 Ib
ae/A-ft
3.15361b
ae/A-ft
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
NS
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
PHI=3
Days
NS
Use Directions and Limitations
(NPDES license restriction). This
product is toxic to fish.
Do not apply through any type of
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not
contaminate water by cleaning of
equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife.
Apply to not more than 1 0 percent
of surface area of water.
Do not use treated water for
domestic purposes until 25 days
after treatment. Do not use
treated water for spraying or
irrigation within 25 days after
treatment. Do not use treated
57
-------
Site
Application
Timing
Hops
Foliar
Industrial
Processing
Water
When Needed
Formulation
[EPA Reg.
No.]
53% SC/L
[4581-174]
[TX99000600]
11.2% G
[4581-172]
15.9% SC/L
[ID87001500]
[WA87001100]
[OR87000400]
53% SC/L
[4581-380]
App. Type and
Equipment
Water Treatment-
Aerial, Ground
Basal Spray
Treatment
Water Treatment-
Metering Pump
Max.
Single
App.
Rate
(ae)
13.51 Ib
ae/A-ft
13.5 Ib
ae/A-ft
0.3459 Ib
ae/A
3.0-0.3
ppm
endothall
technical
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
2
NS
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
PHI= 28
Days
NS
Use Directions and Limitations
water for animal consumption
within 25 days after treatment.
Do not apply when drift is likely
to occur. This product is toxic to
fish. Do not contaminate water,
food, or feed by storage or
disposal. Do not use where fish
are important resources.
Do not apply when drift is likely
to occur. This product is toxic to
fish. Do not contaminate water,
food, or feed by storage or
disposal. Do not contaminate
water intended for irrigation or
domestic purposes.
Do not discharge effluent
containing this pesticide into
sewage systems without notifying
the sewage treatment plant
authority (POTW). Do not
discharge effluent containing this
product into lakes, streams, ponds,
estuaries, oceans, or public water
(NPDES license restriction). This
pesticide is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal.
58
-------
Site
Application
Timing
Irrigation
Systems
When Needed
Formulation
[EPA Reg.
No.]
53% RTU
[AL81000900]
[FL77000100]
53% SC/L
[IN8000800]
[AZ79001000]
53% SC/L
[4581-174]
[TX99000600]
[1448-352]
(max. 3.1536
Ib ae/A-ft)
11.2% G
[4581-172]
App. Type and
Equipment
Surface Treatment-
Aerial, Boat
Injection
Equipment (max.
1 1. 2 Ib ae/A-ft)
Water Treatment
Injection
Equipment,
Sprayer
Water Treatment-
Aerial, Ground
Max.
Single
App.
Rate
(ae)
15.2 Ib
ae/A-ft
0.2 ppm
(L)
13.51 Ib
ae/A-ft
13.5 Ib
ae/A-ft
Max.
Number
Apps. at
Max.
Rate
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
Max.
Seasonal
Rate
(ae)
NS
PHI, PGI,
Pre-
feeding
Interval
NS
Use Directions and Limitations
Apply to not more than 1 0 percent
of surface area of water.
NS
Do not use treated water for
domestic purposes until 25 days
after treatment. Do not use
treated water for spraying or
irrigation within 25 days after
treatment. Do not use treated
water for animal consumption
within 25 days after treatment.
Do not apply when drift is likely
to occur. This product is toxic to
fish. Do not contaminate water,
food, or feed by storage or
disposal. Do not use where fish
are important resources.
Do not apply when drift is likely
to occur. This product is toxic to
fish. Do not contaminate water,
food, or feed by storage or
disposal. Do not contaminate
water intended for irrigation or
domestic purposes.
59
-------
Site
Application
Timing
Lakes/Ponds/
Reservoirs
(With
Human or
Wildlife Use)
When Needed
Potato
Formulation
[EPA Reg.
No.]
53% RTU
[FL77000100]
[AL81000900]
53% SC/L
[4581-174]
53% SC/L
[1448-352]
53% SC/L
[TX99000600]
11.2%G
[TX99000500]
[4581-172]
53% SC/L
App. Type and
Equipment
Surface Water
Treatment -Aerial,
Boat
Injection
Equipment (max.
11.21bae/A-ft)
Surface Water
Treatment-Sprayer
Surface/Subsurface
Tre atment- Sprayer,
Injection
Equipment
Water Treatment-
by hand
Aerial-Low
Max.
Single
App.
Rate
(ae)
15.12 Ib
ae/A-ft
8.008 Ib
ae/A-ft
1.5881b
ae/A-ft
6.807 Ib
ae/A-ft
162 Ib/A-
ft(L)
1.001 Ib
Max.
Number
Apps. at
Max.
Rate
NS
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
1
Max.
Seasonal
Rate
(ae)
NS
NS
PHI, PGI,
Pre-
feeding
Interval
NS
PHI=14
Use Directions and Limitations
Apply to not more than 1 0 percent
of surface area of water.
Apply to not more than 1 0 percent
of surface water. Do not use
treated water for domestic
purposes until 25 days after
treatment. Do not use treated
water for spraying or irrigation
within 25 days after treatment.
Do not use treated water for
animal consumption within 25
days after treatment. Do not
apply when drift is likely to occur.
This product is toxic to fish. Do
not contaminate water, food, or
feed by storage or disposal. Do
not use where fish are important
resources.
Buffer zone restriction (600 feet)
on TX SLN. Do not contaminate
water, food, or feed by storage or
disposal. Do not apply when drift
is likely to occur. This product is
toxic to fish. Do not contaminate
water intended for irrigation or
domestic purposes.
Do not apply through any type or
60
-------
Site
Application
Timing
(White/Irish)
Foliar
Swamps/Mar
shes/Wetland
s/Stagnant
Water
When Needed
Formulation
[EPA Reg.
No.]
[4581-381]
11.2%G
[TX99000500]
App. Type and
Equipment
Volume Spray
Ground-Spray
Water Treatment-
Hand Application
Max.
Single
App.
Rate
(ae)
ae/A
162 Ib
ae/A-ft
(L)
Max.
Number
Apps. at
Max.
Rate
NS
Max.
Number
Apps. per
Year/Crop
Cycle
NS
Max.
Seasonal
Rate
(ae)
NS
PHI, PGI,
Pre-
feeding
Interval
Days
NS
Use Directions and Limitations
irrigation system. Do not apply
directly to water, or to areas
where surface water is present or
to intertidal areas below the mean
high water mark. Do not apply
when drift is likely to occur. Do
not contaminate water by cleaning
of equipment or disposal of
equipment wash waters. This
product is toxic to fish. Do not
contaminate water, food, or feed
by storage or disposal. This
pesticide is toxic to wildlife. Do
not graze treated areas. Do not
feed forage to dairy animals or
animals being finished for
slaughter.
Buffer zone restriction (600 feet).
Do not contaminate water, food,
or feed by storage or dis posal.
61
-------
62
-------
B. Generic Data Requirements and Studies Used to Make the Reregistration Decision
Guide to Appendix B
Appendix B contains listing of data requirements which support the reregistration for active
ingredients within case 2245 Endothall covered by this RED. It contains generic data requirements
that apply to Endothall in all products, including data requirements for which a "typical formulation"
is the test substance.
The data table is organized in the following formats:
1. Data Requirement (Column 1). The data requirements are listed in the order in which they appear
in 40 CFR part 158. The reference numbers accompanying each test refer to the test protocols set in
the Pesticide Assessment Guidance, which are available from the National technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161 (703) 487-4650.
2. Use Pattern (Column 4). This column indicates the use patterns for which the data requirements
apply. The following letter designations are used for the given use patterns.
A Terrestrial food
B. Terrestrial feed
C. Terrestrial non-food
D. Aquatic food
E. Aquatic non-food outdoor
F. Aquatic non-food industrial
G. Aquatic non-food residential
H. Greenhouse food
I. Greenhouse non-food
J. Forestry
K. Residential
L. Indoor food
M. Indoor non-food
N. Indoor medical
0. Indoor residential
3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column list
the identify number of each study. This normally is the Master Record Identification (MRID) number,
but may be a "GS" number if no MRID number has been assigned. Refer to the Bibliography
appendix for a complete citation of the study.
63
-------
New
Guideline
Number
Old
Guideline
Number
Requirement
Use
Pattern
Bibliographic Citation(s)
PRODUCT CHEMISTRY
830.1550
830.1600
830.1620
830.1670
830.1700
830.1750
830.1800
830.6302
830.6303
830.6304
830.6313
830.7000
830.7200
830.7220
830.7300
830.75507
7560/757
0
830.7370
830.78407
7860
830.7950
830.7050
61-1
61-2 A
61-2 B
61-2 B
62-1
62-2
62-3
63-2
63-3
63-4
63-13
63-12
63-5
63-7
63-11
63-10
63-8
63-9
None
Product Identity and
Composition
Description of
Starting Material
Description of
Production Process
Discussion of
Formation of
Impurities
Preliminary Analysis
Certified Limits
Enforcement of
Analytical Method
Color
Physical State
Odor
Stability
pH
Melting Point
Boiling Point
Density
Partition Coefficient
Dissociation
Constant
Water Solubility
Vapor Pressure
UV/Visible
Absorption
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
41616401
41616401, 43873901, 43873902
41616401, 43873901, 43783902
41616401, 43873901, 43873902
41616402, 42427901, Data Gap for 4581-204,
4581-174, 4581-380, 4581-381
41616402
41616402, 42427901
42629701, 42629901, 42629801
42629701, 42629901, 42629801
42629701, 42629901, 42629801
43265001, 43264901, 43265101, Data Gap for
4581-174, 4581-380, 4581-381, 4581-204
42629701, 42629901, 42629801
42629701, 42629901, Data Gap for 4581-174,
4581-380,4581-381
Data Gap for 4581-174, 4581-380, 4581-381
42629701, 42629901, 42629801
43472803, 43441501
42668001, 42787702, 43081301
41622801, 43339301, 43551701, 43472802
41622802,43319601
Data Gap for 4581-257, 4581-204, 4581-174,
4581-380,4581-381
ECOLOGICAL EFFECTS
64
-------
New
Guideline
Number
850.4100
850.4150
850.4230
850.2100
850.2100
850.2300
850.1075
850.1010
850.1075
850.1350
850.1025
850.1400
850.1500
850.1735
850.1400
Old
Guideline
Number
122-1A
122-1B
123-1
71-2
71-1
71-4
72-1
72-2A
72-3 A
72-3B
72-3 C
72-4A
72-4C
Requirement
Seedling Emergence
Vegetative Vigor
Early Seedling
Growth Toxicity
Avian Acute Dietary
Toxicity
Avian Acute Oral
Toxicity
Avian Reproduction
Freshwater Fish
Acute Toxicity
Freshwater
Invertebrate Acute
Toxicity Test
Estuarine/Marine
Fish Acute Toxicity
Test
Estuarine/Marine
Invertebrate Acute
Toxicity
Estuarine/Marine
Invertebrate Early
Life Stage Study
Estuarine/Marine
Toxicity - Mollusk
Estuarine/Marine
Toxicity - Shrimp
Freshwater Fish
Early Life- Stage
Test
Freshwater Fish Life
Cycle Test
Freshwater
Invertebrate Life-
Cycle Test
Freshwater Acute
Sediment Test
Estuarine/Marine
Acute Sediment Test
Use
Pattern
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F,G
Bibliographic Citation(s)
43167701, 43167702, 43167801, 43167802,
43167901,43167902, 00035240, 00035241,
00116270, 00116271, 00035238, 00035239
0160000, 42359501, 00035237, 42359701*,
00074220*, 42359601*
42507301, 42507302*, Data Gap for N,N-
dimethylalkylamine
442327701, 42327702, 40098001, 40094602,
00068507*, 114510*, 113971*, 43472801,
00084149, 00084148, 0084147, 00007113,
43196901, 00046269*, 00071148*00083025*,
42695401, 42695402, 00071134*
42359702, 42695403, 00035242, 00074221,
00074222, 00074227*, 00074228*,
43196902*, 05009242, 40098001, 00071137*,
00115863*, 00017800*, 00084150*, 00084151
42914102, 42695405, 43196903, 00074225,
44700401*, 00074226, 40098001
00074223*, 0074224*, 42895201, 42914101,
43210001, 00035243, 00035244*, 43550201,
42695406, 42695404
Data Gap for N,N-dimethylalkylamine
42895201, 42695404, 43550201
42914101, 42695046, 43210001
43295401, 00095812, 43276501, Data Gap for
N,N-dimethylalkylamine
Data Gap for N,N-dimethylalkylamine
43007801, 43437901
Data Gap for N,N-dimethylalkylamine
Data Gap for N,N-dimethylalkylamine
65
-------
New
Guideline
Number
EPA/600/
RO 1/020
EPA/600/
-99/064
Non-
Guideline
850.3020
850.4400
850.4225
850.4250
850.4400
Old
Guideline
Number
Non-
Guideline
141-1
122-2
123-1A
123-1B
123-2
Requirement
Chronic
Estuarine/Marine
Sediment Testing
65 -day Test in
Chironomous
Tentans
Acute Toxicity to
Amphibians
Honey Bee Acute
Contact Toxicity
Aquatic Plant
Growth
Seedling
Germination/
Seedling Emergence
(Tier II)
Vegetative Vigor
(Tier II)
Aquatic Plant
Toxicity (Tier I)
Aquatic Plant
Toxicity (Tier II)
Use
Pattern
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F, G
Bibliographic Citation(s)
Data Gap for N,N-dimethylalkylamine
Data Gap for N,N-dimethylalkylamine
40098001
44038201
41613809, 44392802
42396405, 43870401, 44392803, 44127801
42396405, 43870401
41613809, 42396401*,42396402*, 42396404,
42396403*, 44392801, 44392802
42396406, 44949402, 44949203, 44127802*,
44127803*, 44127805*, 44127804*,
4427806*, 44976701, 44949202, 44949201,
Ace. 244122*, 44408801
OCCUPATIONAL/RESIDUE EXPOSURE
875.1600
236
Application
Exposure
Monitoring Data
Reporting
44972201, 45250701
TOXICOLOGY
870.1100
N/A
870.1200
870.1300
870.2400
870.2500
870.2600
81-1
N/A
81-2
81-3
81-4
81-5
81-6
Acute Oral Toxicity-
Rat
Maximum Tolerated
Oral Dose Toxicity -
Dog
Acute Dermal
Toxicity-Rabbit/Rat
Acute Inhalation
Toxicity-Rat
Acute Eye Irritation
- Rabbit
Acute Dermal
Irritation
Dermal Sensitization
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
42289201
40745201
42289202
42169501, 42408701
42289203
42289204 (unacceptable)
41871901
66
-------
New
Guideline
Number
870.3100
870.3150
870.3200
870.3465
870.4100
B
870.3700
870.4200
870.3700
870.3800
870.4300
870.5300
870.5100
870.5375
870.5395
870.7485
870.7600
Old
Guideline
Number
82-1A
82-1B
82-2
83-1B
83-3A
83-2B
83-3B
83-4
83-5
84-2
84-2
84-2B
84-2
85-1
85-3
Requirement
90-Day Feeding -
Rodent
90-Day Feeding -
Non-rodent
2 1 -Day Dermal -
Rabbit/Rat
2 8 -day Inhalation
Chronic Feeding
Toxicity - Non-
Rodent
Prenatal
Developmental
Toxicity - Rat
Oncogenicity -
Mouse
Developmental
Toxicity - Rabbit
2-Generation
Reproduction - Rat
Combined Chronic
Toxicity/
Carcinogenicity
Gene Mutation (In
vitro)
Bacterial Gene
Mutation Assay
In vitro Mammalian
Cytogenetics
In vivo Cytogenetics
- Micronucleus
Assay in Mice
Metabolism and
pharmacokinetics
Dermal Penetration
Use
Pattern
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
Bibliographic Citation(s)
43480810
43480801, 43480802
42814101,43465201
Data Gap
40745202
42776301
40685301, 43608301
Data Gap
43152101,43629301
41040301
43437801
43154801 (unacceptable)
41700302
43157401,41700301
42169502, 44263501, 42200101
42169503
ENVIRONMENTAL FATE
NONE
835.2120
835.4100
835.4400
201-1
161-1
162-1
162-3
Dissociation - Non-
guideline
Droplet Size
Spectrum
Hydrolysis
Aerobic Soil
Metabolism
Anaerobic Aquatic
Metabolism
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
42668008, 43551501, 43081301
42427601
44578401, 42289106
44949401
42903901
67
-------
New
Guideline
Number
835.4300
835.2240
835.1230
835.6100
835.6200
NONE
Old
Guideline
Number
162-4
161-2
163-1
164-1
164-2
165-4
Requirement
Aerobic Aquatic
Metabolism
Aqueous Photolysis
Sediment and Soil
Adsorption/
Desorption for
Parent and
Degradates
Terrestrial
Dissipation
Aquatic Field
Dissipation
Bioconcentration in
Fish
Use
Pattern
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F,G
Bibliographic Citation(s)
42618901
42289205, 42289205, 42289205, 42641201,
Ace 259367
41616404
42670101, 42670201
44093403, 44093402, 44820103, 44828802,
44828801, 44820101
42644001,43315801
RESIDUE CHEMISTRY
860.1300
860.1300
860.1340
860.1340
860.1340
860.1360
860.1850
860.1340
171-4A
171-4B
171-4C
171-4D
171-4M
165-1
Nature of Residue -
Plants
Nature of Residues -
Animals
Residue Analytical
Method -Plants
Residue Analytical
Method- Animal
Independent
Laboratory
Validation
Multi-residue
Method
Confined Rotational
Crop
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F, G
A, B, E,
F, G
00040978, 00108102, 00113954, 00113965,
42619201, 42619202, 42619203, 43346601,
44077801
00035451, 00035452, 00113928, 00113963,
00133190, 42792701, 42816601
45156001, 44320401, 44320402, 44320403,
44322001, 44322002, Data Gap for conversion
of monomethyl ester to endothall
45156001, Data Gap for conversion of
monomethyl ester to endothall
Data collection and regulatory analytical
methods are needed for the determination
of endothall, per se, in animal
commodities
Submission of analytic reference
standards for dipotassium and mono-
N,N-dimethylalkylamine salts of
endothall are needed
44608601
43300701, Data Gap
Data Gap - Independent Laboratory Validation
(ILV) of an enforcement method for the
determination of endothall and its monomethyl
ester in fish is needed to support proposed
tolerances on fish.
68
-------
New
Guideline
Number
860.1380
860.1400
860.1480
860.1400
860.1650
860.1500
860.1520
Old
Guideline
Number
171-4E
171-4H
171-4J
171-4G
171-13
171-4K
171-4L
Requirement
Storage Stability
Magnitude of
Residue in Irrigated
Crops
Magnitudes of
residues in Meat,
Milk, Poultry, Eggs
Milk and the Fat,
Meat, and Meat
Byproducts of
Cattle, Goats, Hogs,
Horses and Sheep
Eggs and the Fat,
Meat, and Meat
Byproducts of
Poultry
Magnitude of
Residues in Fish
Analytical Reference
Standards
Crop Field Trials
Processed Food/Feed
Use
Pattern
A,B
A B F
£*-., J-*; J— '•}
F G
1 , VJ
A, B, E,
F, G
A, B, E,
F,G
A, B, E,
F,G
A, B, E,
F,G
A,B
A,B,
Bibliographic Citation(s)
43975901, 44077801, 44106301, 44263502,
44263503, 44263504, 44263505, 44274401,
45146302, Data Gap for additional studies on
processed plant commodities, animal
commodities, and fish.
44343101, 44263506, 44334301, 44263508,
44263507, Data Gap
Data Gap
44820102,43315801
Data Gap
43953101, 45146301, 43975901, 44103701,
44037402, 45034701, 43953101
44093401, 44012101, 45146302, 44037401,
Data Gap (potato, alfalfa seed, cottonseed, and
cotton gin products, apples, field corn, grapes,
orange, rice, sorghum, soybeans, sugar beet,
tomato, and wheat)
69
-------
C. Technical Support Documents
Additional documentation in support of this RED is maintained in the OPP
Regulatory Docket, located in Room 119, Crystal Mall #2, 1801 South Bell Street,
Arlington, VA 22202-4501. It is open Monday through Friday, excluding legal holidays,
from 8:30 am to 4:00 pm.
The docket initially contained preliminary human health and ecological effects
risk assessments and related documents that were published May 11, 2005. The public
comment period closed sixty (60) days later on July 11, 2005. The EPA then considered
comments and revised the risk assessments where appropriate. Final human health and
ecological risk assessments, as well as additional support documents, will be published in
the docket with this RED. These documents include:
Phase 3 Public Comment Documents:
1. Environmental Fate and Ecological Risk Assessment for Endothall-Revised, dated
April 22, 2005
2. Environmental Fate and Effects Division Error-Only Corrections of the Endothall
RED, dated April 22, 2005
3. Endothall: FLED Chapter for the Reregi strati on Eligibility Decision Document (RED),
dated April 18,2005
4. Endothall- Report of the Hazard Identification Assessment Review Committee, dated
June 14, 2004
5. Endothall-Report of the Health Effects Division (HED) Risk Assessment Review
Committee (RARC), dated November 4, 2004
6. Drinking Water Assessment for Endothall for both Terrestrial and Aquatic Uses, dated
May 5, 2004
7. Endothall and its salts: Chronic Dietary Exposure Assessment for the Reregi strati on
Eligibility Decision. Revised per Registrant Corrections, dated April 11, 2005
8. Endothall and its salts: Residue Chemistry Considerations for Reregi strati on Eligibility
Decision. Revised per Registrant Comment for Error Only, dated April 11, 2005
9. Revised Occupational and Residential Exposure Assessment and Recommendations
for the Reregi strati on Eligibility Decision Document for Endothall, dated April 1, 2005
70
-------
10. Occupational and Residential Exposure Assessment-Response to Registrant's Error-
Only Comments, dated March 18, 2005
11. Endothall and Salts: Occupational and Residential Exposure Assessment of
Antimicrobial Uses for the Reregi strati on Eligibility Decision, dated March 3, 2005
12. Ecological Risk from Antimicrobial Uses of Endothall to be Considered in the RED
Document, dated January 12, 2005
13. Review of Endothall (and salts) Incident Reports, dated June 24, 2005
Final Risk Assessments and Additional Supporting Documents:
1. Endothall: FIED Chapter of the Reregi strati on Eligibility Decision Document (RED).
Corrected Following Public Comments, dated September 30, 2005
2. Endothall: FED Response to Public Comments, dated August 26, 2005
3. Environmental Fate and Effects Division Response to Public Comment for the
Endothall RED, dated August 6, 2005
4. Revised Occupational and Residential Exposure Assessment and Recommendations
for the Reregi strati on Eligibility Decision Document for Endothall, dated August 12,
2005
5. Amended Response to a Submitted Dietary Exposure Assessment and a Comment on
Fish Consumption in the US, dated July 25, 2005
6. Response to the Four Residue Chemistry Comments from Cerexagri in their "Response
to the EPAs RED Comments for Endothall," dated August 30, 2005
7. Endothall and its Salts. Residue Chemistry Considerations for Reregi strati on Eligibility
Decision. Revised per Registrant Comments, dated August 30, 2005
8. Endothall: Toxicology Disciplinary Chapter for the Reregi strati on Eligibility Decision
Document (RED), dated December 21, 2004
9. Endothall, Acute Mammalian Toxicity Batching Appendix for Endothall RED
Document, dated September 21, 2005
10. Meeting with Army Corp of Engineers, Meeting Minutes, dated July 27, 2005
11. Revised Endothall and Salts: Occupational and Residential Exposure Assessment of
Antimicrobial Uses for the Reregi strati on Eligibility Decision Document, dated
September 28, 2005
71
-------
12. Addendum to Chronic Dietary Risk Assessment, dated September 29, 2005
13. Closure Call Meeting Minutes, dated September 26, 2005
14. Addendum to Drinking Water Assessment, dated September 29, 2005
72
-------
D. Bibliography
GUIDE TO APPENDIX D
1. CONTENTS OF BIBLIOGRAPHY. This bibliography contains citations of all
studies considered relevant by EPA in arriving at the positions and conclusions stated
elsewhere in the Reregi strati on Eligibility Document. Primary sources for studies in this
bibliography have been the body of data submitted to EPA and its predecessor agencies
in support of past regulatory decisions. Selections from other sources including the
published literature, in those instances where they have been considered, are included.
2. UNITS OF ENTRY. The unit of entry in this bibliography is called a "study." In
the case of published materials, this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency has sought to identify
documents at a level parallel to the published article from within the typically larger
volumes in which they were submitted. The resulting "studies" generally have a distinct
title (or at least a single subject), can stand alone for purposes of review and can be
described with a conventional bibliographic citation. The Agency has also attempted to
unite basic documents and commentaries upon them, treating them as a single study.
3. IDENTIFICATION OF ENTRIES. The entries in this bibliography are sorted
numerically by Master Record Identifier, or "MRID" number. This number is unique to
the citation, and should be used whenever a specific reference is required. It is not
related to the six-digit "Accession Number" which has been used to identify volumes of
submitted studies (see paragraph 4(d)(4) below for further explanation). In a few cases,
entries added to the bibliography late in the review may be preceded by a nine character
temporary identifier. These entries are listed after all MRID entries. This temporary
identifying number is also to be used whenever specific reference is needed.
4. FORM OF ENTRY. In addition to the Master Record Identifier (MRID), each
entry consists of a citation containing standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known submission. Bibliographic
conventions used reflect the standard of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
a. Author. Whenever the author could confidently be identified, the Agency
has chosen to show a personal author. When no individual was identified, the Agency
has shown an identifiable laboratory or testing facility as the author. When no author or
laboratory could be identified, the Agency has shown the first submitter as the author.
b. Document date. The date of the study is taken directly from the
document. When the date is followed by a question mark, the bibliographer has deduced
the date from the evidence contained in the document. When the date appears as (1999),
the Agency was unable to determine or estimate the date of the document.
73
-------
c. Title. In some cases, it has been necessary for the Agency bibliographers
to create or enhance a document title. Any such editorial insertions are contained
between square brackets.
d. Trailing parentheses. For studies submitted to the Agency in the past, the
trailing parentheses include (in addition to any self-explanatory text) the following
elements describing the earliest known submission:
(1) Submission date. The date of the earliest known submission appears immediately
following the word "received."
(2) Administrative number. The next element immediately following the word
"under" is the registration number, experimental use permit number, petition number, or
other administrative number associated with the earliest known submission.
(3) Submitter. The third element is the submitter. When authorship is defaulted to
the submitter, this element is omitted.
(4) Volume Identification (Accession Numbers). The final element in the
trailing parentheses identifies the EPA accession number of the volume in
which the original submission of the study appears. The six-digit
accession number follows the symbol "CDL," which stands for "Company
Data Library." This accession number is in turn followed by an alphabetic
suffix which shows the relative position of the study within the volume.
74
-------
Bibliography Citations for Endothall Acid
MRID Citation
Wright, W.G. (1966) Summary of 1966 Weed Control Trials. (Unpublished study
4459 received Nov 6, 1967 under 464-398; prepared by South Dakota State Univ., Dept. of
Agronomy, submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:003622-C)
Hamson, A.R. (1954) News and Views about New York's Second Most Important
Agricultural Industry: Dry Bean Defoliation. (Cornell VegNews 5(7): 1-3; unpublished
study including letter dated Sep 13, 1954 from A.R. Hamson to unknown recipient,
received Jul 28, 1960 under 359-400; prepared by Cornell Univ., New York State
Agricultural Experiment Station, Dept. of Vegetable Crops, submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:023310-F)
Welker, W.V.; Holm, L.G. (19) Pre-Emergence Herbicide Treatments on Red Beets.
(Unpublished study received Dec 23, 1957 under 524-96; prepared by Univ. of
9984 Wisconsin, Agricultural Experiment Station, Dept. of Horticulture, submitted by
Monsanto Co., St. Louis, Mo.; CDL:223118-Y)
4573
Receipt
Date
06-Nov-
1967
28-Jul-
1960
23-Dec-
1957
15941
19227
20211
22290
22917
23939
24085
24094
E.I. du Pont de Nemours & Company (1954) Spinach Weed Control. (Unpublished study
received Jun 14, 1955 under 352-197; CDL: 002773-G)
Counselman, C.J.; Kincaid, L.R.; Geary, R.J.; et al. (19) Herbicidal Activity of
Chloroxuron (N-4(~p—Chlorophenoxy)-phenyl-N',N'-dimethylurea) and C-2059 (N-3-
Trifluoromethylphenyl)-N', N'-dimethylurea) in Seven Areas of the United States.
(Unpublished study received Jun 29, 1964 under unknown admin, no.; submitted by Ciba
Agrochemical Co., Summit, N.J.; CDL:127559-B)
Grehlinger, P.M.; Johnson, R.; Messinger, D.; et al. (1970) Summary of Tandex Efficacy
Data—Ragweed. (Unpublished study received Apr 17, 1972 under 279-2717; prepared in
cooperation with Amchem and others, submitted by FMC Corp., Philadelphia, Pa.; CDL:
002491-B)
Lyle, M.; Walter, G. (1974) Eptam 10 G Fall Application on Sugar- beets: Crop
Tolerance and Weed Control Summary. (Unpublished study received Feb 20, 1976 under
476-1620; submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:223820-D)
University of Nebraska, Department of Agronomy (1961) Weed Control in Castorbeans
in Nebraska in 1961. (Unpublished study received Mar 18, 1965 under 400-46; submitted
by Uniroyal Chemical, Beth- any, Conn.; CDL:003233-B)
Collins, H.A.; Kincaid, L.R.; Colby, C.M. et al. (1978) Biological Research Report on
Herbicide Efficacy. (Unpublished study received Jan 11, 1978 under 100-437; prepared in
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Sutton, D.L.; Evrard, T.O.; Chappell, W.E. (1959) Weed Control Studies in Farm Ponds
Using Simazine and Other Herbicides. (Unpublished study received Apr 29, 1965 under
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Gallagher, J.E.; Otten, R.J. (1963) Weed Control in Bermuda and Zoysia Grasses.
(Unpublished study received Dec 19, 1963 under 264-156; prepared in cooperation with
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14-Jun-
1955
29-Jun-
1964
08-Oct-
1964
11-May-
1965
17-Apr-
1972
20-Feb-
1976
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19-Dec-
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75
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Timmons; Weldon; Lee; et al. (1959) Herbicides to Control Weeds. (Unpublished study 20-Nov-
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Davis, H.C.; Hidu, H. (19) Effects of pesticides on embryonic development of Clams and
75816 Oysters and on survival and growth of the Larvae. Fishery Bulletin 67(2):393-400,403. 02-Jan-
(also in unpublished submission received Jan 2, 1980 under 2217 -485; submitted by FBI - 1980
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Miller, C.W.; Lowe, J.I. (19) Toxicity of Herbicides to Estuarine Animals. (U.S. Bureau 05-Jan-
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Washington State University, Agricultural Extension Service (1965) Washington State
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27000 Seed. Rev. Pullman, Wash.: WSU, AES. (E.M. 2179; pp. 52-53 only; also in unpublished U2'uct-
submission received Oct 2, 1967 under 8F0643; submitted by Stauffer Chemical Co.,
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Walker, C.R. (1966) Aquatic Weed Control. (Summary of unpublished paper presented at
the 23rd Annual North Central Weed Control Conference; 1966; unpublished study
28032 received may 28, 1968 under 352-247; prepared by Illinois, Natural History Survey and " &y"
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Fults, J.; Blouch, R.; Thornton, B. (1952) Summary of Data Relative to use of Karmex W
Herbicide and Karmex DW Herbicide on Potatoes. (Unpublished study received Feb 4, 04-Feb-
1956 under PP0062; submitted by E.I. du Pont de Nemours & Co., Wilmington, Del; 1956
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Frank, P. A. (1971) Evaluation of Aquatic Herbicides. (Unpublished paper prepared for
the Weed Science Society meeting; Feb 3-5, 1970, Montreal, Canada; unpublished study .
28441 received Jul 13, 1971 under 1E1046; prepared by U.S. Agricultural Research Service, , „_,
Crops Protection Branch, submitted by U. S. Dept. of the Army, Office of the Chief of
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Sibbald, J.H. (1968) Test Report: MSMA as a Silvicide. (Unpublished study received Dec „, -
29786 4, 1968 under 6308-58; submitted by Ansul Chemical Co., Weslaco, Tex.; CDL:007869-
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Chisholm, K.W.; Ekms, W.L. (1979) Norton EC + Betanex and/or Bet- anal
Postemergence EUP Program for 1978 and 1979: Efficacy and Crop Safety Data. 02-Jan-
(Unpublished study received Jan 2, 1980 under 10065-EX-4; submitted by Fisons Corp., 1980
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Blackburn, R.D.; Weldon, L.W. (1964) Control of Southern Naiad in Florida drainage
and irrigation channels. Weeds 12(4):295-298. (also in unpublished submission received 15-Sep-
Sep 15, 1972 under 1F1101; submitted by Chevron Chemical Co., Richmond, Calif.; 1972
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Younger, V.B. (1958) Kikuyugrass, Pennisetum clandestinum, and its control. Southern
,-„ ,~ California Turfgrass Culture 8(1): 1-2. (also in unpublished submission received Feb 20, 20-Feb-
1959 under 464-164; submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:022959- 1959
A)
Stewart, D.; Nelson, R.T.; Laumeister, L.T.; et al. (1961) Weed Control in Plants.
(Unpublished study including published data, received Feb 14, 1961 under 4581 -79; 14-Feb-
prepared in cooperation with U.S. Agricultural Research Service, Field Crops Re- search 1961
Branch, Sugar Crops Section and others, submitted by Pennwalt Corp., Agchem Div.,
76
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King of Prussia, Pa.; CDL:007437-A)
Stroube, E.W.; Zielke, R.C.; Nylund, R.E.; et al. (1964) Efficacy Study. (Unpublished
study received Nov 25, 1964 under 4581 - 234; prepared in cooperation with Ohio State 25-Nov-
Univ., Agricultural Experiment Station and others, submitted by Pennwalt Corp., 1964
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Union Carbide Agricultural Products Company (1958) Clover Control with 2,4,5 -TP. 09-Jul-
(Unpublished study received Jul 9,1958 under 264-76; CDL:001871-A) 1958
Fink, R. (1975) Final Report: Eight-Day Dietary LCISO-Mallard Ducks: Project No. 110-
106. (Unpublished study received Oct 21, 1975 under 4581-EX-18; prepared by Truslow 21-Oct-
Farms, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 1975
096340-B)
Keckemet, O. (1975) Substantive Amendment to Pesticide Petition No. 3F1416 (Also
Designated as Pesticide Petition No. 4G1449- Temporary Tolerance and Temporary
35234 Permits 4581-EXP-18G and 4581 - EXP-21G). (Unpublished study received Oct 21, 1975 1975
under 4581 - EX-18; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.;
CDL:096340-C)
Pennwalt Corporation (1975) Fish and Wildlife Safety. (Unpublished study received Jan 05-Jan-
5, 1978 under 1F1105; CDL:096705-A) 1978
Pennwalt Corporation (1970) Beneficial Insect Safely. (Unpublished study received Jan 05-Jan-
5, 1978 under 1F1105; CDL:096705-K) 1978
Pennwalt Corporation (1952) Accident Exposure Experience: (Endothall). (Unpublished 05-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096705-L) 1978
Syracuse University Research Corporation (1969) Fate of Herbicides in the Aquatic ~_ N
35405 Environment. (In cooperation with New York State, Conservation Dept., unpublished , „__
study; CDL:091753-F)
Pennwalt Corporation Product Chemistry: Data Requirements. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL: 096703-A) 1978
Pennwalt Corporation (1977) Quality Control Specifications forFuran. (Unpublished 05-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096703-B) 1978
Pennwalt Corporation (1962) Analysis of Endothall acid, PF-3441. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL: 096703-C) 1978
Pennwalt Corporation (1976) Analytical Procedure for Endothall Technical. Method „_ -,
35430 dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703- ''
D)
Whitaker, R.L. (1977) Product Stability. (Unpublished study received Jan 5, 1978 under „-
35432 1F1105; submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096703- ~
G)
Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL: 096703-1) 1978
Pennwalt Corporation (1970) A Rapid Method for the Determination of Primary,
Secondary and Tertiary Aliphatic Amines in Mixtures. Calculation of Neutralization
35435 Equivalents and Amine Numbers. Method A-26 dated Mar 23, 1970. (Unpublished study 05-Jan-
mcludmg letters dated Dec 2, 1976 from W. Whitla to Harold Lmdaberry and Jun 2, 1977 1978
from L.D. Metcalfe to Harold Linda- berry, received Jan 5, 1978 under 1F1105;
CDL:096703-L)
77
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Pennwalt Corporation (1976) Analytical Procedure for Hydrothol(R) 191 Liquid,
Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide), and Herbicide 283. Method 05-Jan-
dated Apr 1976. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703- 1978
M)
Pennwalt Corporation (1975) Residue Chemistry: I. Summary. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL:096703-P) 1978
Pennwalt Corporation (1975) Analytical Method for Residues of Endothall in Various „- ^
35440 Crops and Other Materials. Method dated May 1975. (Unpublished study received Jan 5, , „_„
1978 under 1F1105; CDL:096703-Q)
Pennwalt Corporation (19) Storage Stability of Endothall Residues. (Unpublished study 05-Jan-
JM41 received Jan 5, 1978 under 1F1105; CDL:096703-R) 1978
Pennwalt Corporation (1974) Results of Residue Determinations: Disappearance of „- -,
35442 Endothall in Water. (Unpublished study received Jan 5, 1978 under 1F1105; i QTR"
CDL:096703-S)
Pennwalt Corporation (1975) Results of Residue Determinations: Residues in Irrigated 05-Jan-
Crops. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-U) 1978
Pennwalt Corporation (1977) Results of Residue Determinations: Animals (Meat, Milk, 05-Jan-
andEggs). (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-V) 1978
Pennwalt Corporation (1972) Metabolism and Fate of Endothall: Aquatic Environment „- -,
35446 (Water, Aquatic Plants, and Hydrosoil). (Unpublished study received Jan 5, 1978 under , „_„
IF 1105; CDL: 096703-W)
Pennwalt Corporation (1960) Metabolism and Fate of Endothall: Fish. (Unpublished 05-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096703-X) 1978
Pennwalt Corporation (1975) Metabolism and Fate of Endothall: Crops. (Unpublished 05-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096703-Y) 1978
Pennwalt Corporation Metabolism and Fate of Endothall: Animals. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL:096703-Z) 1978
Pennwalt Corporation Metabolism and Fate of Endothall: Soils. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL:096703-AA) 1978
Pennwalt Corporation (1976) A Further Characterization of 14C Activity Resulting in „- ^
35451 Goats Milk after Feeding 14C Endothall. (Unpublished study received Jan 5, 1978 under , j™
1F1105; CDL: 096703-AB)
Smith, K.S. (1976) 14C-Endothall Feeding Study in Lactating Goats: Laboratory No. 6E-
2214. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon 05-Jan-
Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 1978
CDL:096703-AC)
Pennwalt Corporation (1954) Toxicology Endothall. (Unpublished study received Jan 5, 05-Jan-
35453 1978 under 1F1105; CDL:096703-AE) 1978
Pennwalt Corporation Analytical Method, Residues, and Metabolites. (Unpublished study 05-Jan-
JMM received Jan 5, 1978 under 1F1105; CDL:096703-AF) 1978
Pennwalt Corporation Fate and Persistence in the Environment. (Unpublished study 05-Jan-
received Jan 5, 1978 under 1F1105; CDL:096703-AG) 1978
Pennwalt Corporation (1952) Safety to Manufacturer, Applicator, and User. (Unpublished 05-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096703-AH) 1978
78
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Surber, E.W.; Pickering, Q.H. (1962) Acute toxicity of Endothal, Diquat, Hyamine,
Dalapon, and Silvex to fish. Progressive Fish-Culturist (Oct): 164-171. (U.S. Public
Pennwalt Corporation (1963) Reasonable Grounds in Support of the Petition: Summary: 05-Jan-
Endothall. (Unpublished study received Jan 5, 1978 under 1F1105; CDL:096703-AD) 1978
Pennwalt Corporation (1976) Analytical Procedure for Aquathol(R) (Endothal Turf
Herbicide and Endothal Weed Killer), Aquathol K, Herbicide 273 and Aquathol 05-Jan-
Granular. Method dated Apr, 1976. (Unpublished study received Jan 5, 1978 under 1978
1F1105;CDL:096703-F)
Pennwalt Corporation (1975) Environmental Chemistry: Conclusions. Summary of „- ^
36528 studies 096704-B, 096704-D through 096704-G, 096704-L and 096704-M. (Unpublished u:)-Jan-
study received Jan 5, 1978 under 1F1105; CDL:096704-A)
Carlson, R.E.; Sandeno, J.L. (1970) Effect of Endothall on the Growth of Several Fungi. „- -,
36529 (Unpublished study received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., , „_„
Agchem Div., King of Prussia, Pa.; CDL: 096704-B)
Watson, J.D.; Isensee, A.R. (1972) The Results of Tests on the Amount of Residue
Remaining, Including a Description of the Analytical Method Used: (Endothall).
36538 (Unpublished study received Jan 5, 1978 under 1F1105; prepared in cooperation with 05-Jan-
U.S. Agricultural Research Service, Plant Science Div., Crop Protection Research 1978
Branch, Pesticide Investigations-Behavior in Soils, submitted by Pennwalt Corp.,
Agchem Div., King of Prussia, Pa.; CDL:096704-M)
Pennwalt Corporation (1977) Human Safety: Summary of Toxicity Data. Summary of „- -,
36540 studies 096704-D through 096704-J, 096704-M and 096704-BV through 096704-BY. LO-Jan-
(Unpublished study received Jan 5, 1978 under 1F1105; CDL:096707-O)
Latven, A.R. (1975) Endothall Technical (N.B. 58-196-2). (Unpublished study received Q5 J&n
36541 Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by , „_„
Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-Q)
Latven, A.R. (1975) Ripenthol N.B. 58-188-3 (Isopropyl-butanol Formulation).
(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology 05-Jan-
Research, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; 1978
CDL: 096704-Y)
Latven, A.R. (1975) Ripenthol N.B. 58-191-2 (Water Only Formula-tion). (Unpublished
36548 study received Jan 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., , „_„
submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-Z)
Stevens, K.R. (1976) Teratologic Evaluation of Endothal in Rats: Laboratory No. 5129.
, ,.„, (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Food and Drug 05-Jan-
Research Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, 1978
Pa.; CDL:096704-BV)
Latven, A.R. (1975) Ripenthol N.B. 58-191-2 (23.4%). (Unpublished study including
letter dated Aug 14, 1975 from A.R. Latven to Obren Kechemet, received Jan 5, 1978 05-Jan-
under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 1978
Agchem Div., King of Prussia, Pa.; CDL: 096704-CA)
Walsh, G.E. (1970) Effects of Pesticides: Report No. 2-119a. (U.S. Fish and Wildlife 03-Sep-
Service, Bureau of Commercial Fisheries, un- published study; CDL:091902-R) 1971
Brimhall, P.B. (1969) 1969 Herbicide Report. (Unpublished study including letter dated
Dec 19, 1969 from P.B. Brimhall to Barry Regan, received May 1, 1971 under 1F1165; 01-May -
prepared by Northern Ohio Sugar Co., submitted by Dow Chemical U.S.A., Midland, 1971
Mich.;CDL:090959-F)
01-Jan-
79
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Health Service, Robert A. Taft Sanitary Engineering Center, published study; 18-Mar-
CDL:095428-F) 1976
Scott, R.A., Jr.; Gangstad, E.O. (1970) Technical Report of Monitoring Guidelines for
Use-Registration of Herbicides in Quiescent Aquatic Sites: AD882977. Includes undated
methods en- titled: Extraction of Butoxyethanol ester of 2,-4D from water and analysis by
gas chromatography; Extraction of 2,4-D acid, amines, and mineral salts from water and
analysis by gas chromatography; Extraction of Isooctyl and PGBE ester of Phenoxy acid 13-Jun-
herbicides from water and analysis by gas chromatography; Extraction of Dichlobenil 1975
from water and analysis by gas chromatography; Analytical method for residues of
Endothall in water. (Unpublished study received Jun 13, 1975 under 5E1648; prepared by
U. S. Dept. of the Army, Office of the Chief of Engineers and Pennwalt Corp., submitted
by Chevron Chemical Co., Richmond, Calif.; CDL:095428-H)
Blackburn, R.D.; Gangstad, E.O. (1970) Efficacy and Residues of Diquat Applied for
Control of Egeria and Hydrilla. (Unpublished study received Jun 13, 1975 under 5E1648; 13-Jun-
prepared by U.S. Agricultural Research Service, Florida/Antilles Area and others, 1975
submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428-I)
Schreck, C.B.; Berry, C.R.; Strange, R.J.; et al. (1974) Ecosystem Studies on the Use of
Diquat and Endothal for Aquatic Plant Con- trol in a Large Potable Water Supply
Reservoir: Contract No. DAW-65-74-C-0013. (Virginia, Commission of Game and ,,, ^
38643 Inland Fisheries and Virginia Polytechnic Institute and State Univ., Dept. of Fisheries and
Wildlife Sciences for U.S. Dept. of the Army, Office of the Chief of Engineers, Aquatic
Plant Control Program, Interagency Technical Advisory Committee, unpublished study;
CDL:095428-Y)
Strange, R.J. (1975) The Effects of Herbicides on Primary Productivity, Phytoplankton
Dynamics, and Water Chemistry of an Aquatic System. Master's thesis, Virginia 13-Jun-
Polytechnic Institute and State Univ. (Unpublished study received Jun 13, 1975 under 1975
5E1648; submitted by Chevron Chemical Co., Richmond, Calif.; CDL:095428-Z)
Van Horn, S.L. (1975) Dissipation of the Herbicides Endothall, Diquat, and a 1:1 Mixture
in Water, Sediment, and Egeria densa. Master's thesis, Virginia Polytechnic Institute and 13-Jun-
State Univ. (Unpublished study received Jun 13, 1975 under 5E1648; submitted by 1975
Chevron Chemical Co., Richmond, Calif.; CDL:095428-AA)
MacEwen, J.D. (1963) Toxicity Studies on Endothal acid: Development File No. 342.44- 10-Apr-
40960 ^ ^' (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Wayne State 1966
Univ., Dept. of Industrial Medicine and Hygiene, submitted by Pennsalt Chemical Corp., 14-Apr-
Bryan, Tex.; CDL:090587-C) 1966
Brieger, H. (1953) Endothal Short-Term Oral Toxicity Test: Dogs. (Unpublished study ^
40962 received Apr 10, 1966 under 6G0503; prepared by Jefferson Medical College, submitted
by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-E) 14-Apr-
Pennsalt Chemical Corporation (19) Residue Studies on Cotton-seed. (Unpublished 10-Apr-
40966 study received Apr 10, 1966 under 6G0503; CDL:090587-I) 1966
Lee, W.M.; Munter, P.A. (1953) Endothal—Residue Analysis—Progress Report. ,„ .
40971 (Unpublished study received Apr 10,1966 under 6G0503; submitted by Pennsalt ,
-------
Apr 10, 1966 under 6G0505; submitted by Pennsalt Chemical Corp., Bryan, Tex.; 1966
CDL:090587-Q)
Carlson, R.E. (1966) Bioassy of Endothal. Undated method. (Unpublished study received ,„
40975 Apr 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex., ~
CDL:090587-S)
Munter, P. A. (1954) Determination of Endothal Residues in Plant Material. Undated ,„
40976 method. (Unpublished study received Apr 10, 1966 under 6G0503; submitted by Pennsalt , „/
Chemical Corp., Bryan, Tex.; CDL:090587-T)
14-Feb-
Montgomery, M.; Freed, V.H. (1961) The Absorption and Metabolism of Endothal when 1961
Used as a Post-emergence Treatment for Beets— Progress Report. (Unpublished study 08-Jul-
received Apr 10, 1966 under 6G0503; prepared by Oregon State Univ., Agricultural 1965
Chemistry Dept., submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-U) 10-Apr-
1966
15-Dec-
1964
21-Jan-
1965
08-Jul-
Montgomery, M.L.; Freed, V.H. (1964) Endothal. (Unpublished study received Apr 10,
40981 1966 under 6G0503; prepared by Oregon State Univ., Dept. of Agricultural Chemistry,
submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-Y)
J ^ J ' 10-Apr-
1966
15-Feb-
1967
15-Apr-
1970
10-Apr-
Oregon State University (19) Preliminary Study on Microbial Effect on Endothal.
40982 (Unpublished study received Apr 1 0, 1 966 under 6G0503 ; submitted by Pennsalt '
Chemical Corp., Bryan, Tex.; CDL:090587-Z)
1970
Bowles, E.J.; Carlson, R.E. (1964) Endothall Analysis. (Unpublished study received Apr ,„
40985 10, 1966 under 6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; '
CDL:090587-AC)
Anon. (1967) 1967 Pennsylvania Guide, Chemical Weed Control for Vegetable Crops:
Selection, Application, Safety. University Park, Pa.: Pennsylvania State Univ., Extension 02-Oct-
Service. (Incomplete; also in unpublished submission received Oct 2, 1967 under 1967
8F0643; submitted by Stauffer Chemical Co., Westport, Conn.; CDL:091 1 16-AI)
Pennwalt Corporation (1973) Hydrothol 191 Rice Herbicide Summary-- Research Field 10-Jul-
Tests. (Unpublished study received Jul 10, 1975 under 4581-18; CDL:243210-A) 1975
Burkhalter, A.P. (1972) Guidelines for Aquatic Weed Control. Rev. By Florida, Dept. of _. M
44465 Natural Resources, Bureau of Aquatic Plant Research and Control. Tallahasee, Fla. : , „_ ,
Florida, DNR. (Published study; CDL:022791-A)
Swabey, Y.H.; Schenk, C.F. (1963) Report on Algicides and Aquatic Herbicides. 12-Jan-
46269 (Ontario, Water Resources Commission, Laboratory Division, Biology Branch, 1965
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81
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1966
Fink, R. (1975) Final Report: Eight-Day Dietary LC50-Bobwhite Quail: Project No. 110-
105. (Unpublished study received Oct 21, 1975 under 4581-EX-18; prepared by Truslow 21-Oct-
Farms, Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 1975
096340-A)
Silvo, O.E.J. (1967) Alustavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta
Nuorille Karpin Poikasille (Cyprinus carpio L.). N.P. (Suomen Kalatalous 32 Finlands 11-Jul-
Fiskerier; incomplete; also in unpublished submission received Jul 11, 1961 under 1961
1E1046; submitted by U.S. Dept. of the Army, Washington, D.C.; CDL:093359-X)
Keckemet, O. (1974) Letter sent to Charlotte M. Young dated Feb 25, 1974 Efficacy „, M
57411 studies on rice. (Unpublished study received May 1, 1974 under 4F1499; submitted by , „_ .
Umroyal Chemical, Bethany, Conn.; CDL:094551-D)
Pennwalt Corporation (19) Endothall Technical. Tacoma, Wash.: Pennwalt. (Product data oi F h
58568 bulletin no. 13c; also in unpublished submission received Feb 1, 1975 under 3F1416; , „_-
CDL:093785-D)
Pennwalt Corporation (1973) Analytical Method for Residues of Endothall in Various 01 F b
58575 Crops and Other Materials. Method dated May 1973. (Unpublished study received Feb 1, , „_£.
1975 under 3F1416; CDL:093785-N)
Latven, A.R. (1977) Toxicology Report for ...: Endothall acid # 3441. (Unpublished study ~, „
58722 received Oct 26, 1978 under 4581-282; prepared by Pharmacology Research, Inc., 1~Q78~
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:235435-D)
Brieger, H. (19) Results of Sub-acute Feeding Tests with Endothal. (Unpublished study
61096 received on unknown date under unknown admin, no.; prepared by Jefferson Medical
College, Div. of Industrial Medicine, submitted by ; CDL:109899-A)
Anon. (1966) Summary of Toxicity Studies with Endothal Formulations on Animals.
61097 (Unpublished study received on unknown date under unknown admin, no.; submitted by ;
CDL: 109890-A)
Anon. (1967) Acute Oral LD50 Data for Aquatic Herbicides. (Unpublished study 18-Nov-
receivedNov 18, 1968 under unknown admin, no.;; CDL:109792-A) 1968
Simsiman, G.V.; Daniel, T.C.; Chesters, G. (1976) Diquat and endothall: Their fates in
the environment. Residue Reviews 62:131- 174. (Also in unpublished submission 22-Aug-
received Aug 22, 1977 under 239-1663; submitted by Chevron Chemical Co., Richmond, 1977
Calif.; CDL:231430-E)
Schreck, C.B. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water
Supply Reservoir: Contract No. DACW65-74- C-0013. (Virginia Polytechnic Institute 22-Aug-
and State Univ., Dept. of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, 1977
Corps of Engineers; unpublished study; CDL: 23143 3-D)
Pennsalt Chemical Corporation (1967) Chemical Data Regarding Des-i-cate. 08-May-
(Compilation; unpublished study received May 8, 1967 under 7G0608; CDL:092900-A) 1967
Pennwalt Corporation (1970) Chemical Data Regarding Endothall. (Unpublished study 01-Feb-
6/762 received Feb 1, 1975 under 4581-EX-21; CDL: 094575-A) 1975
Keckemet, O. (1975) Reasonable Grounds in Support of the Petition for Residue 01 F b
67763 Tolerance: Endothall. (Unpublished study received Feb 1, 1975 under 4581-EX-21; , „_£.
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:094575-F)
69050 Pennwalt Corporation (1979) Human Safety: Summary of Toxicity Data. Summary of 23-Jan-
82
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studies 099882-C and 099882-E through 099882-1. (Unpublished study received Jan 23, 1981
1981 under IF 1105; CDL: 099882-B)
Knickerbocker, M.; Becci, P.J. (1980) Teratologic Evaluation of Endothall in Rats:
Laboratory No. 5129. (Unpublished study, including letters dated Dec 31, 1980 from
69051 C.H. Williams to Obren Keckemet and Jan 7, 1981 from R.A. Parent to Bernalyn 1981 ~
McGaughey, received Jan 23, 1981 under 1F1105; prepared by Food and Drug Research
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099882-C)
Curren, R.D.; Schechtman, L.M.; Parmar, A.S.; et al. (1980) Activity of T1604 in the
Salmonella/Microsomal Assay for Bacterial Mutagenicity: Study No. T1064.102. Final ,,, -,
69054 report. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by
Microbiological Associates, submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL:099882-G)
Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro
Mammalian Cell Point Mutation Assay in the Absence of Exogenous Metabolic
69055 Activation: Study No. T1604.106. Final report. (Unpublished study received Jan 23, 1981
under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:099882-H)
Schechtman, L.M.; Beard, S.F.; Sinsky, P.M. (1980) Activity of T1604 in the in vitro
Mammalian Cell Point Mutation Assay in the Presence of Exogenous Metabolic
69056 Activation: Study No. T1604.107. Final report. (Unpublished study received Jan 23, 1981 "
under 1F1105; prepared by Microbiological Associates, submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:099882-I)
Rodwell, D.E.; Spencer, A.G.; Allen, S.; et al. (1980) Range- finding Study in Non- 23-Jan-
pregnant Female Mice: IRDC No. 470-004. (Unpublished study received Jan 23, 1981 1981
under IF 1105; prepared by International Research and Development Corp., submitted by 29-Jan-
Pennwalt Corp., Philadelphia, Pa.; CDL:099882-J) 1981
Bond, C.E.; Lewis, R.H.; Fryer, J.L. (1960) Toxicity of various herbicidal materials to 18-Mar-
fishes. Pages 96-101, In Transactions of the 1959 Seminar of Biological Problems in 1976
Water Pollution. By Robert A. Taft Engineering Center. Cincinnati, Ohio: U.S. Public 26-Apr-
Health Service. (Technical report W60-3; published study; CDL:230691-H) 1977
Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies ,,, ^
71130 244131-B through 222131-R. (Unpublished study received Jan 23, 1981 under 4581-174; ''
CDL:244131-A)
Bodden, R.M. (1979) Avian Single-dose Oral LD50: Study No. W-910. (Unpublished
study, including letter dated Jul 8, 1980 from R.M. Bodden to Obren Keckemet, received 23-Jan-
Jan 23, 1981 under 4581-174; prepared by Ralston Purina Co., submitted by Pennwalt 1981
Corp., Philadelphia, Pa.; CDL:244131-B)
Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall to the Water Flea
71, ,7 Daphnia magna Straus: UCES Project No. 11506- 41-09. (Unpublished study received 23-Jan-
Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt 1981
Corp., Philadelphia, Pa.; CDL:244131-I)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate)
Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 23-Jan-
11506-41-11. (Un-published study received Jan 23, 1981 under 4581-174; prepared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-O)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate) __ ^
71143 Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus , „„,
(Linnaeus): UCES Project No. 11506-41-12. (Unpublished study received Jan 23, 1981
83
-------
under 4581 -174; prepared by Union Carbide Corp., submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:244131-P)
Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980
(Summary of results of 48-hour mussel embryo bio- assay performed on Endothall): SRI
71145 Project LSC-1514-6. (Unpublished study, including letter dated Jun 20, 1980fromH.C.
Bailey to Bernalyn D. McGaughey, received Jan 23, 1981 under 4581-174; prepared by
SRI International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-R)
Pennwalt Corporation (1981) Human Safety: Introduction. (Unpublished study received 25-Mar-
Mar 25, 1981 under 4581-223; CDL:099955-D) 1981
Bodden, M.R. (1979) Avian Single-dose Oral LD50: Study No. W-910. Final report.
(Unpublished study, including letter dated Jul 8, 1980 from R.M. Bodden to Obren 23-Jan-
Keckemet, received Jan 23, 1981 under 1F1105; prepared by Ralston Purina Co., 1981
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-B)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate)
72464 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 23-Jan-
11506-41-11. (Unpublished study received Jan 23, 1981 under IF 1105; prepared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-O)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate)
Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus
72465 (Linnaeus): UCES Project No. 11056-41-12. (Unpublished study received Jan 23, 1981
under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:099883-P)
U.S. Department of Interior, Bureau of Reclamation (1964) Results of Algaecidal __ -,
72467 Evaluation Tests of Selected Compounds: Report No. WC-21. Annual progress report, of , „„,
1964, laboratory studies. (Unpublished study; CDL:099883-U)
Keckemet, O. (1973) Reasonable Grounds in Support of the Petition: Endothall. 01 F h
73305 (Unpublished study, including published data, received Feb 1, 1975 under 3F1416; , „__
submitted by Pennwalt Corp., Tacoma, Wash.; CDL:093785-H)
Pennwalt Corporation (1977) Human Safely: Summary of Toxicity Data. Summary of 96 O t
73337 studies 235435-B through 235435-E. (Unpublished study received Oct 26, 1978 under , „_„
4581-282; CDL:235435-A)
Rodwell, D.E.; Goldenthal, E.I.; Blair, M.; et al (1980) Teratology Study in Mice: Study
733?1 No. 470-006. (Unpublished study received Jan 23, 1981 under 4581 -174; prepared by 23-Jan-
International Research and Development Corp., submitted by Pennwalt Corp., 1981
Philadelphia, Pa.; CDL:244123-J)
Obom, E.T.; Bartley, T.R. (1954) Tolerance of Crops to Herbicides in Irrigation Water:
Laboratory Report No. SI-3. (U.S. Agricultural Research Service, Field Crops Research
73854 Branch and U.S. Dept. of the Interior, Bureau of Reclamation, Office of the Assistant
Commissioner and Chief Engineer, Engineering Laboratories; unpublished study;
CDL:090913-I)
Bodden, R.M. (1979) Avian Single-dose Oral LD50. (Unpublished study received Jan 23, _, T
74220 1981 under 4581-282; prepared by Ralston Purina Co., submitted by Pennwalt Corp., , „„,
Philadelphia, Pa.; CDL:244122-B)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate)
74774 Technical 89.5% Acid Equivalent to the Fiddler Crab, Uca pugilator: UCES Project No. 23-Jan-
11506-41-11. (Unpublished study received Jan 23, 1981 under 4581-282; pre-pared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-O)
84
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Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Endothall (Acid Monohydrate)
Technical 89.5% Acid Equivalent to the Common Mummichog Fundulus heteroclitus
74225 (Linnaeus): UCES Project No. 11506-41-12. (Unpublished study received Jan 23, 1981
under 4581 -282; prepared by Union Carbide Corp., submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:244122-P)
Bailey, H.C. (1980) Letter sent to Bernalyn D. McGaughey dated Sep 19, 1980 Results of
48-hour mussel embryo bioassay performed on Endothal: SRI Project LSC-1514-6. 23-Jan-
(Unpublished study received Jan 23, 1981 under 4581-282; prepared by SRI 1981
International, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-R)
Pennwalt Corporation (19) Toxicity Testing Protocols: Mussel Embryo Test. 23-Jan-
(Unpublished study received Jan 23, 1981 under 4581 -282; CDL:244122-S) 1981
Brieger, H. (1950) Preliminary Toxicity Studies on Endothal. (Jefferson Medical College, ~, ,,
75236 Div. of Industrial Medicine for U.S. Food and Drug Administration; unpublished study; , „-,
CDL: 109911-A)
Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology
reports on seven products. (Unpublished study received Jan 5, 1978 under 4581-174; 05-Jan-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 1978
Pa.; CDL:232580-B)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Endothall
Technical (N.B. 58-196-2). (Unpublished study received Jan 5, 1978 under 4581-174; 05-Jan-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 1978
Pa.; CDL:232580-C)
Stevens, K.R. (1976) Teratologic Evaluation of Endothall in Rats: Laboratory No. 5129.
78611 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Food and Drug 05-Jan-
Research Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 1978
232580-BI)
Sikka, H.C.; Saxena, J. (1973) Metabolism of endothall by aquatic microorganisms.
Journal of Agricultural and Food Cl
submission received Feb 1, 1975un
Philadelphia, Pa.; CDL:094575-G)
Journal of Agricultural and Food Chemistry 21 (3):402-406. (Also in unpublished 01-Feb-
submission received Feb 1, 1975 under 4581-EX-21; submitted by Pennwalt Corp., 1975
04-Feb-
Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect
80437 to the Safety of the Product. (Unpublished study received Feb 4, 1966 under 6G0503;
CDL:090585-B) in^"
1966
Montgomery, M.L.; Freed, V.H. (1964) Preliminary Study on Microbial Effect on
80439 Endothal. (Unpublished study received Feb 4, 1966 under 6G0503; prepared by Oregon 04-Feb-
State Univ., Dept. of Agricultural Chemistry, submitted by Pennsalt Chemicals Corp., 1966
Tacoma, Wash.; CDL:090585-D)
Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. , ,
81397 Summary of studies 051133-B through 051133-M and 051133-R. (Unpublished study
received Apr 14, 1966 under 4581- 70; CDL:051133-A)
15-Dec-
Keller, J.G.; Platt, W.R.; Stemgruby, P.B. (1964) Final Report on Three-week Repeated 1964
Dermal Application of Herbicide 282 to Albino Rabbits: S.A. No. 95431. (Unpublished 14-Apr-
study received Apr 14, 1966 under 4581 -70; prepared by Scientific Associates, Inc., 1966
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 051133-D) 10-Jun-
1966
85
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U.S. Agricultural Research Service (1954) Toxicity of Endothal to Sheep. (Field Crops £
81403 Research Branch, Irrigation Experiment Station, Weed Investigation Section; unpublished
study; CDL: 051 133-G) 1 966~
Brieger, H. (1953) Endothal: Long-term Oral Toxicity Test. (Unpublished study received £
81404 Apr 14, 1966 under 4581 -70; prepared by Jefferson Medical College, submitted by
Pennwalt Corp., Philadelphia, Pa.; CDL:051 133-H) ™~
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate),
89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 23-Jan-
11506-41-10. (Unpublished study received Jan 23, 1981 under 4581-174; prepared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-L)
Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 25-Mar-
received Mar 25, 1981 under 4581 -223; CDL: 244664-A) 1981
25-Mar-
Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 1981
244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 14-Sep-
1981
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate),
89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 23-Jan-
11506-41-10. (Unpublished study received Jan 23, 1981 under 1F1105; prepared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-L)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Endothall (Acid Monohydrate),
841 Si 89.5% Acid Equivalent, to the Grass Shrimp Palaemonetes pugio: UCES Project No. 23-Jan-
11506-41-10. (Unpublished study received Jan 23, 1981 under 4581-282; prepared by 1981
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-L)
Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and
Fates of Herbicides in Rice Fields and in Rice-field Effluents: Progress report WRC
84382 Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublished study .
received Oct 8, 1981 under 476-2107; prepared by Univ. of California --Davis, Dept. of
Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:24601 1-M)
Carlson, R.; Whitaker, R.; Landskov, A. (1978) Endothall. Pages 327-340, In Analytical
8460? Methods for Pesticides and Plant Growth Regulators. New York, N. Y.: Academic Press, 14-Sep-
Inc. (also in unpublished submission received Sep 14, 1981 under 4581-349; submitted 1981
by Pennwalt Corp., Philadelphia, Pa.; CDL:246016-B)
Pennwalt Corporation (1951) Human Safety: Summary of Toxicity Data. (Unpublished 14-Sep-
846UJ study received Sep 14, 1981 under 4581-349; CDL:246012-A) 1981
Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J ,. „
84604 through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; ''
CDL:246012-B)
Pennwalt Corporation (1979) Teratology: Endothall. (Unpublished study received Sep 14, 14-Sep-
1981 under 4581 -349; CDL:246012-D) 1981
Pennwalt Corporation Metabolism Studies: Endothall. (Unpublished study received Sep 14-Sep-
8460/ 14, 1981 under 4581 -349; CDL: 246012-E) 1981
Pennwalt Corporation (1972) Mutagenicity Studies: Endothall. (Unpublished study 14-Sep-
received Sep 14, 1981 under 4581 -349; CDL: 246012-1) 1981
86
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Ralston Purina Company (1981) Endothal Granular Turf Herbicide: RT Lab No. 867431. ,. „
84613 (Unpublished study received Sep 14, 1981 under 4581 -349; submitted by Pennwalt Corp., , „„,
Philadelphia, Pa.; CDL: 246012-O)
Blair, M.; Nemec, M.D.; Bajo, C.; et al. (1981) Teratology Study in Mice: 470-006. 02-Jul-
(Unpublished study received Sep 3, 1981 under IF 1105; prepared by International 1981
Research and Development Corp., submitted by Pennwalt Corp., Tacoma, Wash.; CDL: 03-Sep-
070277-A; 070276) 1981
Scribner, J.D. (1981) Evaluation of Studies on Genetic Toxicity of Endothall. ,„ -, ,
86622 (Unpublished study received Jul 29, 1981 under 4581-204; submitted by Pennwalt Corp., , „„,
Philadelphia, Pa.; CDL:245680-D)
Pennwalt Corporation (1981) Endothall Teratology Study in Mice. (Unpublished study 12-Nov-
received Nov 12, 1981 under IF 1105; CDL: 070448-A) 1981
Bowmer, W.J. (1981) Letter sent to Richard F. Mountfort dated Dec 14, 1981 ^ Dgc
88988 Information on residue and deposition of drift data. (Texas, Dept. of Agriculture, , „„,
Agricultural & Environmental Sciences Div.; unpublished study; CDL:246530-A)
Landskov, A. O. (1981) Letter sent to Letha Coenen dated Nov 25, 1981: Residues of ,„ -
88989 endothall on cotton seed. (Unpublished study received Dec 28, 1981 under TX 81747;
prepared by Pennwalt Corp., submitted by state of Texas, Austin, Tex.; CDL:246531-B)
Anon. (1954) Toxicity of Endothal to Sheep. (Unpublished study received on unknown
date under unknown admin, no.; CDL: 109906-A)
Fang, S.C.; Tinsley, I. (1967) Metabolism of C14I-labeled Disodium 3,6-
Endoxohexahydrophthalate (Endothall) in Rats. Final report. (Unpublished study,
96294 including letter dated Oct 14, 1966 from R.E. Carlson to D.M. Baker, Jr., received Feb
17, 1967 under 7F0570; prepared by Oregon State Univ., Dept. of Agricultural
Chemistry, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-E)
Menzie, C.M. (1964) Letter sent to H.L. Lindaberry dated Oct 15, 1964 Toxicity to
96299 mallards. (U.S. Fish and Wildlife Service, Patuxent Wildlife Research Center, Section of
Chemical and Physiological Studies; unpublished study; CDL:090719-K)
Peoples, S.A. (1965) The Excretion of Cl 4 Tagged Endothall in the Rat. (Unpublished
96300 study received Feb 17, 1967 under 7F0570; prepared by Univ. of California --Davis, Dept. 17-Feb-
of Physical Sciences, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL: 1967
090719-L)
Maestri, M. (1967) Structural and Functional Effects of Endothall on Plants. 17-Feb-
(Unpublished study, including letter dated Nov 3, 1966 from H.B. Currier to Edward J. 1967
Bowles, received Feb 17, 1967 under 7F0570; prepared by Univ. of California--Davis, 15-Apr-
Dept. of Botany, submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-R) 1970
Tischler, N; Bates, J.C.; Quimba, G.P. (1949) A New Group of Defoliant-herbicidal Q5 Q
97377 Chemicals. (Unpublished study received Dec 5, 1949 under unknown admin, no.; , „ ,„
submitted by Sharpies Chemical, Inc., Philadelphia, Pa.; CDL: 109908-A)
Carlson, R.E. (1977) Letter sent to Obren Keckemet dated Oct 25, 1977: Effect of yeast Q5 J&n
97424 culture on endothall. (Unpublished study received Jan 5, 1978 under 1F1105; submitted , „_„
by Pennwalt Corp., Philadelphia, Pa.; CDL:096704-E)
Applied Biochemists, Incorporated Nomenclature, Chemical and Physical Properties of
Endothal Technical (Acid) and Cutrine, a Copper Triethanolamine Complex. 21-Dec-
(Compilation; un- published study received Dec 21, 1972 under unknown admin, no.; 1972
CDL: 127670-A)
87
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Schreck, C.; Corning, R.; Berry, C.; et al. (1974) Aquatic Plant Control Using Herbicides
in a Large Potable Water Supply Reservoir. Annual report, Jul 1, 1973—Jun 30, 1974:
100609 Contract No. DACW65 -74-C-OO13. (Virginia Polytechnic Institute and State Univ., Dept. ~ e°"
of Fisheries and Wildlife Sciences for U.S. Dept. of the Army, Corps of Engineers;
unpublished study; CDL:247354-B)
Silvo, O. (1967) Alustavia Tutkimuksia Eraiden Herbisidien Myrkyllisyydesta Nuorille
Karpin Poikasille (Cyprinus catpio L.). Helsinki, Fin.: species name. (Suomen Kalatalous 03-Feb-
32; also in unpublished submission received Feb 3, 1976 under 960-163; sub- mitted by 1976
Balcom Chemicals, Inc., Greeley, CO; CDL:228944-V)
Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining,
Including a Description of the Analytical Methods Used: (Endothall). (Unpublished study 01 -Feb-
received Feb 1, 1975 under 4G1449; submitted by Pennwalt Corp., Tacoma, WA; CDL: 1975
093861-A)
Moffett, J.; Morton, H.; MacDonald, R. (1972) Toxicity of some herbicidal sprays to 26-Sep-
111488 honey bees. Journal of Economic Entomology 65(l):32-36. (Also In unpublished 1974
submission received Sep 26, 1974 under 464-323; submitted by Dow Chemical U.S.A., 15-Dec-
Midland, MI; CDL:120345-H) 1983
Agchem (1959) Environmental Studies on Endothal. (Compilation; unpublished study 03-Dec-
received Dec 3, 1959 under 4581-139; CDL: 007440-A) 1959
Agchem (1966) Description of Analytical Methods and Results of Analyses for 14 F h
113927 Dimethylcocoamine Endothall (Accelerate) in Cotton- seed. (Compilation; unpublished , „,,
study received Feb 14, 1966 under 4581-284; CDL:007456-A)
Kennedy, G. (1970) Report to Pennwalt Corporation: Distribution of 14C-Endothall in
the Goat: IBT No. E8392. (Unpublished study received Dec 15, 1970 under OF0972; 15-Dec-
prepared by Industrial Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, 1970
WA; CDL:091670-A)
Kennedy, G. (1970) Report to Pennwalt Corporation: Characterization of 14C in Milk
and Urine of Goats Following Oral Administration of 14C-Endothall: IBT No. E8392. 15-Dec-
(Unpublished study received Dec 15, 1970 under OF0972; prepared by Industrial Bio-Test 1970
Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:091670-B)
Kennedy, G.; Jenkins, D. (1970) Report to Pennwalt Corporation: Tissue Residue Study
with 14C Labeled Endothall in Pre-conditioned and Naive White Leghorn Chickens: IBT ,. _
15 )ec
113930 No. J8352. (Unpublished study received Dec 15, 1970 under OF0972; prepared by
Industrial Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA;
CDL:091670-C)
Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the „, ~
113934 Product: Endothall. (Unpublished study received Dec 1, 1970 under 1F1105; submitted , „_„
by Pennwalt Corp., Tacoma, WA; CDL:094510-A)
Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 01-Dec-
(Compilation; unpublished study received Dec 1, 1970 under IF 1105; CDL:094508-A) 1970
Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 01-Dec-
Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507-A) 1970
Pennwalt Corp. (1970) Study: Hydrothol Efficacy. (Compilation; unpublished study 01-Dec-
lljyj/ received Dec 1, 1970 under IF 1105; CDL: 094507-B) 1970
Pennwalt Corp. (1972) Toxicity Study: Endothall on Rats & Fish. Summary of studies ~,
113938 094506-C and 094506-D. (Unpublished study received May 31, 1972 under IF 1105;
CDL:094506-B)
88
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1972
Walsh, G. ( 1 97 1 ) Effects of Herbicides on Photosynthesis and Growth of Marine , , ,,
1 1 3952 Unicellular Algae. (Environmental Protection Agency, Gulf Breeze Laboratory; , „__
unpublished study; CDL:094506-F)
28-Apr-
1972
Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining,
1 1 3953 Including a Description of the Analytical Method Used: Endothall. (Compilation; ^
unpublished study received May 13, 1972 under 1F1 105; CDL:094506-H) J3
Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after
1 13954 Treatment with Endothall and 14C Endothall Formulated as DBS -I-CATE. (Compilation;
unpublished study received on unknown date under 1F1057; CDL:093370-A)
Pennwalt Corp. (1971) Name, Chemical Identity and Composition of Pesticide Chemical: ,„ -,
1 13957 Endothall. (Compilation; unpublished study received Jan 20, 1971 under 1F1057; , „_,
CDL:093370-E)
Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the ,, .
1 13959 Product: Endothall. (Unpublished study received Aug 1 1, 1971 under 1F1057; submitted '
by Pennwalt Corp., Tacoma, WA; CDL:091892-A)
Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of „_
1 13961 the Product: Endothall. Summary of studies 091673-B through 091673-E. (Compilation;
unpublished study received Apr 7, 1970 under OF0972; CDL:091673-A)
07-Apr-
Pennwalt Corp. (1968) Study: 14C Endothall Residue in Specified Products. 1970
(Compilation; unpublished study received Apr 7, 1970 under OF0972; CDL:091673-D) 15-Apr-
1970
Pennwalt Corp. (1963) Uptake, Distribution and Metabolism of Endothall in Blue Gills. 01 -May -
(Unpublished study received May 1, 1974 under 4G1510; CDL:094010-D) 1974
Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of „, ,,
1 1 397 1 the Product: Endothall. (Compilation; unpublished study received on unknown date under , „_ ,
1F1105; CDL:094509-A)
08-Jul-
Oregon State Univ. (1 962) Progress Report on the Endothal Project. Progress report no.
1 13974 2. (Unpublished study received Jul 8, 1965 under 4581-232; submitted by Agchem Div., i~970 ~
Pennwalt Corp., Philadelphia, PA; CDL: 121844-B) M Noy
1984
Montgomery, M. (1962) Letter sent to O. Keckemet dated Oct 16, 1962 Endothal in soil.
Progress report, no. 3. (Unpublished study received Jul 8, 1965 under 4581-232; prepared 08-Jul-
by Oregon State Univ., Dept. of Agricultural Chemistry, Agricultural Experiment Station, 1965
submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL: 121844-C)
08-Jul-
Comes, R.; Bohmont, D.; Alley, H. (1961) Movement and persistence of endothal as 1965
. 10077 influenced by soil texture, temperature, and moisture levels. Journal of the A.S.S.B.T. 01 -Dec -
XI(4):287-293. (Also In unpublished submission received Jul 8, 1965 under 4581- 232; 1970
submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:121844-L) 14-Nov-
1984
1 13978 Agchem Movement and Persistence of Endothal under Controlled Conditions. 08-Jul-
89
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(Unpublished study received Jul 8, 1965 under 4581-232; CDL: 121844-M) 1965
Temby, F. (1963) Biological Breakdown of Endothal Compounds. (Unpublished study „„ T i
113979 received Jul 8, 1965 under 4581-232; submitted by Agchem Div., Pennwalt Corp., , „,<-
Philadelphia, PA; CDL: 121844-N)
Temby, F. (1963) Soil Movement Studies with Endothal Compounds. (Unpublished study „„ T i
113980 received Jul 8, 1965 under 4581-232; submitted by Agchem Div., Pennwalt Corp., , „,-
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Temby, F. (1963) Soil Adsorption Studies—Endothal Compounds. (Un-published study „„ T i
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Hiltibran, R. Duration of toxicity of endothal in water. Source unknown. (Also In
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Freed, V.; Montgomery, M.; Fang, S. (1958) The Absorption and Translocation of C14 08-Sep-
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Agchem (1970) The Results of Tests on the Amount of Residue Remaining Including a __ -,
113987 Description of the Analytical Method Used: Endothall. (Compilation; unpublished study , „_,
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Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and „„ -, ,
114487 Complete Composition of the Product: Endothall. (Compilation; unpublished study , „__
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Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the „„ ^ ,
114488 Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study , „__
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Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test „„ -, ,
114492 Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under , „__
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Schreck, C. (1974) Aquatic Plant Control Using Herbicides in a Large Potable Water
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Pennwalt Corp. (1972) Biomagnification: Endothall. (Compilation; unpublished study 09-Jul-
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Oregon State Univ. Preliminary Study on Microbial Effect on Endothal. (Unpublished
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Lewandowski, T. (1953) Letter sent to P. Munter dated Aug 20, 1953: Microbiological
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Freed, V.; Montgomery, M. (1963) Progress Report on the Study of the Degradation .
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X)
Agchem (1961) Chemical Study: Endothal. (Compilation; unpublished study received 15-Mar-
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Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336-H, „ , ,. ,
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Food and Drug Research Laboratories, Inc. (1976) Teratologic Evaluation- -Agri cultural „ , ^
114534 Chemical FDRL/Wistar Rats: Protocol No. 7608 1 . (Unpublished study received Jun 4, " ™"
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Pennwalt Corp. (1969) Determination of Endothall Residues in Cottonseed and ,-
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Watson, J. (1 970) Full Reports of Investigations Made with Respect to the Safety of the , _
1 14540 Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15,
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15-Nov-
3M Co. (1965) Chemical and Physical Properties: System E. (Unpublished study received 1973
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1975
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Kohn, F.; Kay, D. (1968) Report to Minnesota Mining and Manufacturing Co: Acute 1968
1 1 4S48 Toxicity Studies on 3ME68H: Lifestream Laboratories Project Nos. 984 through 988. 15-Nov-
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Economon, P. (1967) Letter sent to W. Paterson dated Nov 3, 1967 Results of bioassay
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Whitley, J. (1 968) Letter sent to W. Paterson dated Nov 1 8, 1 968 Four-day fish toxicity 15-Nov-
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1 1 4556 (Unpublished study received Oct 26, 1 978 under 458 1-282; submitted by Agchem Div. , ~ ° "
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BASF Wyandotte Chemical Corp. (1973) Chemical Study: Pyramin-283. (Compilation; 30-Jan-
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Fink, R. (1975) Eight-day Dietary LC50»Bobwhite Quail: Technical Endothal: Project
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Fink, R. (1975) Eight-day Dietary LC50-Mallard Ducks: Technical Endothal: Project
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Reregistration for Endothall. Transmittal of 2 studies.
Bettencourt, M. (1992) Endothall Technical-Acute Toxicity to Bluegill Sunfish (Lepomis
macrochirus) under Flow-through Conditions: Lab Project Number: 91-9-3917:
12442.0591.6121.105. Unpublished study prepared by Springborn Laboratories, Inc. 62
P-
Bettencourt, M. (1992) Endothall Technical-Acute Toxicity to Rainbow Trout
(Oncorhynchus mykiss) Under Flow-through Conditions: Lab Project Number: 91 -9-
3918: 12442.0591.6120.108. Unpublished study prepared by Springborn Laboratories,
Inc. 63 p.
Atochem North America (1992) Submission of Data in Support of Endothall Acid
(Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2
studies.
McNamara, P. (1992) Endothall Technical—Acute Toxicity to Daphnids (Daphnids
magna) Under Flow-through Conditions: Final Report: Lab Project Number: 91-10-3946:
12442.0591.6122.115. Unpublished study prepared by Springborn Labs., Inc. 64 p.
Atochem North America, Inc. (1992) Submission of toxicity data in support of the data
call-in for Endothall. Transmittal of 1 study.
Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Endothall Technical in the
Rat: Lab Project Number: 91-8355. Unpublished study prepared by Bio/dynamics, Inc.
132 p.
Atochem North America, Inc. (1992) Submission of product chemistry data in support of
the reregistration of endothall. Transmittal of 1 study.
Douglass, M. (1992) Endothall--Analysis of Product Samples: Lab Project Number:
4200-91-0279-AS: 4200-91-0279-AS-001. Unpublished study prepared by Ricerca, Inc.
71 p.
ELF Atochem (1992) Submission of toxicity data to support endothall reregistration.
Transmittal of 2 studies.
20-Apr-
1992
20-Apr-
1992
20-Apr-
1992
20-Apr-
1992
20-Apr-
1992
26-May-
1992
26-May-
1992
26-May-
1992
17-Jun-
1992
17-Jun-
1992
21-Jul-
1992
21-Jul-
1992
05-Aug-
1992
05-Aug-
1992
10-Oct-
1992
Pedersen, C.; Fletcher, D. (1992) Endothall Technical: Toxicity and Reproduction Study 10-Oct-
97
-------
42507302
42619200
42619201
42619202
42619203
42629700
42629701
42641200
42641201
42641202
42668000
42668001
42776300
42776301
42792700
in Mallard Ducks: Lab Project Number: 89 DR 37. Unpublished study prepared by Bio-
Life Associates, Ltd. 300 p.
Pedersen, C.; Fletcher, D.; Lesar, C. (1992) Endothall Technical: Toxicity and
Reproduction Study in Bobwhite Quail: Lab Project Number: 89 QR 41. Unpublished
study prepared by Bio-Life Associates, Ltd. 301 p.
Atochem North America, Inc. (1992) Submission of residue data in support of the data
call-in for Endothall Acid (technical). Transmittal of 3 studies.
Sanger, T. (1992) Nature of the Residue in Alfalfa: (carbon 14)-Endothall: Final Report:
Lab Project Number: HWI 6120-154: BR-91-48. Unpublished study prepared by
Hazleton Wisconsin, Inc. 108 p.
Sanger, T. (1992) Nature of the Residue in Cotton: (carbon 14)-Endothall: Final Report:
Lab Project Number: HWI 6120-152: BR-91-49. Unpublished study prepared by
Hazleton Wisconsin, Inc. 138 p.
Sanger, T. (1992) Nature of the Residue in Sugar Beets: (carbon 14)-Endothall: Final
Report: Lab Project Number: HWI 6120-150: BR-91-50. Unpublished study prepared by
Hazleton Wisconsin, Inc. 114 p.
Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the
data call-in for Endothall Acid (technical). Transmittal of 1 study.
Sweetapple, G. (1992) Endothall Acid Monohydrate, TG-Color, Physical State, Odor,
Melting Point, Bulk Density, pH: Lab Project Number: 4200-92-0172-AS: 4200-92-
0172-AS-001. Unpublished study prepared by Ricerca, Inc. 36 p.
Atochem N. A., Inc. (1992) Supplemental Submission of environmental fate data to
support the Endothall reregistration. Transmittal of 2 studies.
Zwick, T.; Kazee, B.; Marsh, S. (1992) Photodegradation of (carbon 14)-Endothall in
Water under Artificial Light: Amended Final Report: Lab Project Number: SC890059:
N0758-4400. Unpublished study prepared by Battelle. 92 p.
Saxena, A.; Zwick, T.; Marsh, S.; et al. (1992) Photodegradation of (carbon 14)-Endothall
on Sandy Loam under Artificial Light: Amended Final Report: Lab Project Number:
SC890060: BR-90-02. Unpublished study prepared by Battelle. 67 p.
Atochem North America (1993) Submission of product chemistry data in support of the
data call-in for Endothall Acid (Technical). Transmittal of 1 study.
Gallacher, A. (1993) Endothall Acid Monohydrate—Dissociation Constant: Lab Project
Number: 4200-92-0133-AS: 4200-92-0133 -AS-001. Unpublished study prepared by
Ricerca, Inc. 54 p.
Elf Atochem North America, Inc. (1993) Submission of toxicity data in support of the
reregistration DCI for Endothall Acid. Transmittal of 1 study.
Trutter, J. (1993) Rat Developmental Toxicity Study with Disodium Salt of Endothall:
Final Report: Lab Project Number: 153-146. Unpublished study prepared by Hazleton
Washington, Inc. 289 p.
Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to
DCI for Endothall Acid (Technical). Transmittal of 2 studies
Sanger, T. (1993) Metabolism of (carbon 14)-Endothall in Lactating Goats: Final Report:
42792701 Lab Project Number: HWI 6120-158: BR-91-52. Unpublished study prepared by
Hazleton Wisconsin, Inc. 103 p.
1992
10-Oct-
1992
08-Jan-
1993
08-Jan-
1993
08-Jan-
1993
08-Jan-
1993
21-Jan-
1993
21-Jan-
1993
27-Jan-
1993
27-Jan-
1993
27-Jan-
1993
17-Feb-
1993
17-Feb-
1993
18-May-
1993
18-May-
1993
01-Jun-
1993
01-Jun-
1993
98
-------
42816600
42816601
42895200
42895201
42914100
42914101
42914102
43007800
43007801
43081900
43081901
43152100
43152101
43167700
43167701
43167702
43265000
Elf Atochem North America, Inc. (1993) Submission of residue data in response to DCI
for reregistration of Endothall Acid (Technical). Transmittal of 1 study.
Sanger, T. (1993) Metabolism of (carbon 14)-Endothall in Laying Hens: Final Report:
Lab Project Number: HWI 6120-160: BR-91-51. Unpublished study prepared by
Hazleton Wisconsin, Inc. 118 p.
Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of
Endothall Acid as Required for Reregistration. Transmittal of 1 study.
Dionne, E. (1993) Endothall Technical-Acute Toxicity to Eastern Oyster (Crassostrea
virginica) Under Flow-through Conditions: Final Report: Lab Project Number: 93-4-
4715: 12442.0591.6125.504. Unpublished study prepared by Springborn Laboratories,
Inc. 68 p.
Elf Atochem North America, Inc. (1993) Submission of Acute Toxicology Data for
Endothall Acid (Technical) in Support of Reregistration. Transmittal of 2 Studies.
Bettencourt, M. (1993) Endothall Technical-Acute Toxicity to Mysid Shrimp
(Mysidopsis bahia) Under Flow-Through Conditions: Final Report: Lab Project Number:
12442.0591.6124.515: 93-3-4711. Unpublished study prepared by Springborn Labs, Inc.
67 p.
Bettencourt, M. (1993) Endothall Technical-Acute Toxicity to Sheepshead Minnow
(Cyprinodon variegatus) Under Flow-Through Conditions: Final Report: Lab Project
Number: 92-1-4901: 12442.0591.6123.505. Unpublished study prepared by Springborn
Labs, Inc. 65 p.
Elf Atochem North America, Inc. (1993) Submission of Toxicology Data in Support of
Endothall Data Call-in. Transmittal of 1 Study.
Putt, A. (1993) Endothall Technical (Acid)—The Chronic Toxicity to Daphnia magna
Under Flow-Through Conditions: Final Report: Lab Project Number: 92-11-4525:
12442.0692.6148.130. Unpublished study prepared by Springborn Labs, Inc. 99 p.
Elf Atochem North America, Inc. (1993) Submittal of Corrosion Characteristics Data in
Support of Reregistration of Endothall Acid Monohydrate. Transmittal of 1 study.
Sweetapple, G. (1993) Endothall Acid Monohydrate, TG—Corrosion Characteristics: Lab
Project Number: 4200-92-0173-AS. Unpublished study prepared by Ricerca, Inc. 36 p.
Elf Atochem North America, Inc. (1994) Submission of toxicity data in support of
reregistration for Endothall Acid Technical. Transmittal of 1 study.
Trutter, J. (1993) Two-Generation Reproduction Study in Rats with Disodium Salt of
Endothall: Final Report: Lab Project Number: 153/142. Unpublished study prepared by
Hazleton Washington, Inc. 1479 p.
Elf Atochem North America, Inc. (1994) Submittal of Dietary Toxicity Data in Support
of Reregistration of Endothall Acid. Transmittal of 2 studies.
Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8-Day Acute Dietary LC 50
Study in Bobwhite Quail: Lab Project Number: 106-011-01. Unpublished study prepared
by Bio-Life Associates, Ltd. 96 p.
Pedersen, C.; Solatycki, A. (1994) Endothall Technical: 8-Day Acute Dietary LC 50
Study in Mallard Ducklings: Lab Project Number: 106-015-02. Unpublished study
prepared by Bio-Life Associates, Ltd. 94 p.
Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data
in support of reregistration of Endothall Acid Monohydrate. Transmittal of 1 study.
01-Jun-
1993
01-Jun-
1993
24-Aug-
1993
24-Aug-
1993
08-Sep-
1993
08-Sep-
1993
>8-Sep-
1993
15-Nov-
1993
15-Nov-
1993
11-Jan-
1994
11-Jan-
1994
09-Mar-
1994
09-Mar-
1994
22-Mar-
1994
22-Mar-
1994
22-Mar-
1994
10-Jun-
1994
99
-------
43265001
43295400
43295401
43300700
43300701
43327700
43327701
43339300
43339301
43558200
43558201
43558202
43558300
43558301
43558302
43953100
Malone, S. (1994) Endothall Acid Monohydrate TG (B44-26-3): Stability: Lab Project
Number: 4200/92/0184/AS. Unpublished study prepared by Ricerca, Inc. 56 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data in Support of
Endothall Reregistration. Transmittal of 1 Study.
Bettencourt, M. (1994) Endothall Technical (Acid)—The Toxicity to Fathead Minnow
(Pimephales promelas) During an Early Life-stage Exposure: Final Report: Lab Project
Number: 93-1-4567: 12442.0692.6149.120. Unpublished study prepared by Springborn
Labs, Inc. 84 p.
Elf Atochem North America, Inc. (1994) Submission of Environmental Fate Data in
Support of Endothall Reregistration. Transmittal of 1 Study.
Sanger, T. (1994) (Carbon 14)-Endothall: Accumulation in Confined Rotational Crops
(Greenhouse Study): Final Report: Lab Project Number: HWI 6120-148: BR-91-47:
R149104. Unpublished study prepared by Hazleton Wisconsin, Inc. 240 p.
Elf Atochem North America, Inc. (1994) Submittal of Toxicity Data in Support of
Reregistration for Endothall. Transmittal of 1 study.
Armondi, S. (1994) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with
Accelerate: Lab Project Number: PH-424-ANA-003-93. Unpublished study prepared by
Pharmakon Research International, Inc. 107 p.
Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in
Support of Endothall Reregistration. Transmittal of 1 Study.
Lorence, P. (1994) Endothall Acid Monohydrate, PAI-Solubility: Lab Project Number:
4200-92-0135-AS: 4200-92-0135-AS-001. Unpublished study prepared by Ricerca, Inc.
84 p.
Elf Atochem North America, Inc. (1995) Submission of Hazard to Non- target Organisms
Data in Support of Endothall Reregistration. Transmittal of 2 Studies.
Rose, S.; Goin, L. (1994) Endothall Technical: 28-Day Dietary Toxicity and
Reproduction Pilot Study in Mallard Ducks: Addendum: Diet Analyses: Final Report:
Lab Project Number: 89 DRP 37: 33400. Unpublished study prepared by NPC, Inc.;
Columbia Labs, Inc.; and Bio-Life Associates, Ltd. 49 p.
Rose, S.; Goin, L. (1994) Endothall Technical: Toxicity and Reproduction Study in
Mallard Ducks: Addendum: Diet Analyses: Final Report: Lab Project Number: 89 DR 37:
0660: 09356. Unpublished study prepared by NPC, Inc.; Columbia Labs, Inc.; and Bio-
Life Associates, Ltd. 47 p.
Elf Atochem North America, Inc. (1995) Submission of Toxicity Data in Support of the
Endothall Registration Standard. Transmittal of 2 Studies.
Rose, S.; Goin, L. (1994) Endothall Technical: 28-Day Dietary Toxicity and
Reproduction Pilot Study in Bobwhite Quail: Addendum: Diet Analyses: Final Report:
Lab Project Numbers: BLAL 89 QRP 41: 33400: 153-144. Unpublished study prepared
by Columbia Labs, Inc.; NPC, Inc.; Bio-Life Associates, Ltd. 49 p.
Rose, S.; Goin, L. (1994) Endothall Technical: Toxicity and Reproduction Study in
Bobwhite Quail: Addendum: Diet Analyses: Final Report: Lab Project Numbers: BLAL
89 QR 41: 0660: 09356. Unpublished study prepared by Columbia Lab, Inc.; NPC, Inc.;
Bio-Life Associates, Ltd. 47 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall and Salts. Transmittal of 1 Study.
10-Jun-
1994
07-Jul-
1994
07-Jul-
1994
18-May-
1994
18-May-
1994
04-Aug-
1994
04-Aug-
1994
16-Aug-
1994
16-Aug-
1994
24-Feb-
1995
24-Feb-
1995
24-Feb-
1995
24-Feb-
1995
24-Feb-
1995
24-Feb-
1995
15-Mar-
1996
100
-------
43953101
43975900
43975901
44077800
44077801
44106300
44106301
44263500
44263501
44320400
44320403
44578400
44578401
44608600
44608601
44820100
44820101
Guyton, B. (1996) Endothall: Magnitude of the Residue in Potato: Lab Project Number:
BR-93-01: U:\ATOCHEM\BR9301FR.DOC. Unpublished study prepared by McKenzie
Laboratories, Inc. 315 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall, K-Salt. Transmittal of 1 Study.
Guyton, B. (1996) Endothall: Magnitude of the Residue in Sugar Beets: Final Report:
Lab Project Number: BR-93-02. Unpublished study prepared by Elf Atochem North
America and Mckenzie Labs, Inc. 347 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of
Endothall and Salts Reregistration. Transmittal of 1 Study.
Sanger, T. (1996) Storage Stability Data for (carbon 14) Endothall Plant Metabolism
Studies (Addenda to MRID #'s 42619201, 42619202, 42619203): Lab Project Number:
HWI 6120-150: HWI 6120-152: HWI 6120-154. Unpublished study prepared by
Hazleton Wisconsin, Inc. 8 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration for Endothall and Salts. Transmittal of 1 Study.
Sharp, J. (1996) Endothall: Storage Stability of Residues in Cottonseed: Lab Project
Number: BR-93-30: 30-93: PRM-047. Unpublished study prepared by Elf Atochem
North America, Inc. and McKenzie Laboratories, Inc. 170 p.
Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in
Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies.
Bounds, S. (1997) Endothall: Metabolism and Excretion Study in the Rat: Final Report:
Lab Project Number: KP-96-02: 96/1290: 96/EFM001/1290. Unpublished study prepared
by Huntingdon Life Sciences Ltd. 182 p.
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of
Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies.
Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number:
FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p.
Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in
Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study.
Mao, J. (1997) Endothall Amine Salt--Determination of pH Dependent Hydrolysis: Lab
Project Number: 12442.0396.6209.715: KP-96-01: 96-6-6537. Unpublished study
prepared by Springborn laboratories, Inc. 79 p.
Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study.
Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods:
Lab Project Number: A036.50: KP-97-18. Unpublished study prepared by Maxim
Technologies, Inc. 63 p. {OPPTS 860.1360}
Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk
Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and
Salts. Transmittal of 4 Studies.
Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for
Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic
Algicide and Herbicide: Lab Project Number: KP-99-02: WT-86-C-11. Unpublished
study prepared by Elf Atochem. 316 p. {OPPTS 860.1400}
15-Mar-
1996
25-Mar-
1996
25-Mar-
1996
07-Aug-
1996
07-Aug-
1996
10-Sep-
1996
10-Sep-
1996
29-Apr-
1997
29-Apr-
1997
03-Jul-
1997
03-Jul-
1997
11-Jun-
1998
11-Jun-
1998
16-Jul-
1998
16-Jul-
1998
05-May-
1999
05-May-
1999
101
-------
44820102
44820103
44820104
44828800
44828801
44828802
44856300
44856301
44949200
44949201
44949202
44949400
44949401
Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater
Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project
Number: KP-97-14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf
Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400}
Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non-Crop
Uses: Final Report: Lab Project Number: KP-96-14: 98-1-7215: 12442-0896-6214-330.
Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p.
Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing
Endothall: Final Report: Lab Project Number: KP-98-31: 98-11-7564: 12442-0898-6271-
251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p.
Elf Atochem North America (1999) Submission of Environmental Fate Data in Support
of the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and
Hydrothal 191. Transmittal of 2 Studies.
Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall
Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide:
Lab Project Number: ATO KP-97-16: WEI 286.01. Unpublished study prepared by
Waterborne Environmental, Inc. 363 p.
Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation
of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic
Algicide and Herbicide: Lab Project Number: ATOKP-98-32: WEI-286.06. Unpublished
study prepared by Waterborne Environmental, Inc. 69 p.
Elf Atochem North America, Inc. (1999) Submission of Toxicity, Residue Chemistry,
Risk Assessment and Exposure Data in Support of the Petition for Tolerance of Endothall
in/on Edible Fish. Transmittal of 1 Study.
Piccirillo, V. (1999) FQPA Supplemental Information on Endothall: Lab Project Number:
FQPA 499E. Unpublished study prepared by Elf Atochem North America, Inc. 35 p.
Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the
Reregistration of Endothall and its Salts. Transmittal of 2 Studies.
Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96-Hour
Toxicity Test with the Freshwater Diatom (Navicula pelliculosa): Final Report: Lab
Project Number: 299A-102. Unpublished study prepared by Wildlife International Ltd. 38
p. {OPPTS 850.5400}
Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 96-Hour
Toxicity Test with the Freshwater Alga (Anabaena flos-aquae): Final Report: Lab Project
Number: 299A-101. Unpublished study prepared by Wildlife International Ltd. 36 p.
{OPPTS 850.5400}
Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, and
Toxicity Data in Support of the Reregistration of Endothall Acid & Salts. Transmittal of 3
Studies.
Atkins, R.; Peel, D.; Marsh, D. (1999) Aerobic Soil Metabolism of (carbon-14)
Endothall: Lab Project Number: 1134: 2045: KP-97-24. Unpublished study prepared by
PTRL East, Inc. 167 p.
05-May-
1999
05-May-
1999
05-May-
1999
05-May-
1999
05-May-
1999
05-May-
1999
21-Jun-
1999
21-Jun-
1999
20-Oct-
1999
20-Oct-
1999
20-Oct-
1999
20-Oct-
1999
20-Oct-
1999
Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7-Day Toxicity
Test with Duckweed (Lemna gibba G3): Final Report: Lab Project Number: 299A-105.
Unpublished study prepared by Wildlife International Ltd. 34 p. {OPPTS 850.4400}
20-Oct-
1999
44949402
44949403 Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191 (Endothall): A 7-Day Toxicity 20-Oct-
102
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44976701
45034700
45034701
45039500
45039501
45088200
45088229
45146300
45146301
45146302
45156000
45156001
45219000
45219001
Test with The Freshwater Alga (Selenastrum capricornutum): Final Report: Lab Project
Number: 299A-103. Unpublished study prepared by Wildlife International Ltd. 36 p.
{OPPTS 850.5400}
Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the
Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191.
Transmittal of 1 Study.
Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96-Hour Toxicity Test with
the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A-
104. Unpublished study prepared by Wildlife International, Ltd. 38 p. {OPPTS
850.5400}
IR-4 Project (2000) Submission of Residue Chemistry Data in Support of the Petition for
Tolerance of Endothall in/on Hops. Transmittal of 1 Study.
Arsenovic, M. (2000) Endothall: Magnitude of the Residue on Hops: Lab Project
Number: 06575: 06575.97-CAR07: 06575. 97-ID22. Unpublished study prepared by IR-4
Project. 125 p. {OPPTS 860.1500}
Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study.
Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project
Number: KP-023-00. Unpublished study prepared by Elf Atochem North America, Inc.
74 p. {OPPTS 850.7100}
US EPA (2000) Submission of Toxicity and Environmental Fate Data in Support of the
Registration of various Triazine and other Pesticides. Transmittal of 32 Studies.
Hiltibran, R. (1967) Effect of Some Herbicides on Fertilized Fish Eggs and Fry. Trans.
Am. Fish. Soc. 96:414-416.
Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies.
Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potatoes:
Final Report: Lab Project Number: KP-98-22: 22A-98: 22B-98. Unpublished study
prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500}
Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potato
Processing Fractions: Final Report: Lab Project Number: KP-98-23: 44884: 23A-98.
Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS
860.1520}
Elf Atochem North America, Inc. (2000) Submission of Residue Data in Support of the
Reregistration of Endothall Acid and Salts. Transmittal of 1 Study.
Gresham, M. (2000) Analysis for Residues of Endothall Using HPLC-MSD: Lab Project
Number: KP-98-49: 44280. Unpublished study prepared by ABC Labs., Inc. 123 p.
{OPPTS 860.1340}
Elf Atochem North America, Inc. (2000) Submission of Toxicity, Residue Chemistry,
Environmental Fate, Risk Assessment and Exposure Data in Support of the Petition for
Tolerance of Endothall in/on Apples and Cotton. Transmittal of 2 Studies.
Davis, C. (2000) FQPA Supplemental Information on Endothall Petition 7F4868:
Endothall on Apples: Lab Project Number: FQPA 697F. Unpublished study prepared by
Elf Atochem North America, Inc. 37 p.
45219002 Davis, C. (2000) FQPA Supplemental Information on Endothall Petition 7F4867:
1999
20-Oct-
1999
20-Oct-
1999
24-Jan-
2000
24-Jan-
2000
28-Jan-
2000
28-Jan-
2000
12-Apr-
2000
12-Apr-
2000
19-Jun-
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26-Sep-
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26-Sep-
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
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Shellenberger,T (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
92057003 00084613. Primary Eye Irritation of Endothal Granular to Rabbits: Project No. 867431.
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
92057004 40109204. Primary Dermal Irritation Study of Endothall Pelleted with the Rabbit: Project
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Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
92057006 40745202. Chronic Feeding in the Rodent Endothall in the Non-Rodent: Project IRI
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
92057007 40685301. Oncogenicity Feeding Study of Disodium Endothall in Mice: Project No.
WIL-75009. Prepared by WIL Research Laboratories. 15 p.
Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID
92057008 00069054. Activity of the Endothall in the Salmonella/Microsomal Assay for Bacterial
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Plankenhorn, L. (1990) Agchem Division-Pennwalt Corp. Phase 3 Reformat of MRID
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92057999 Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Endothall.
2000
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2004
)8-Dec-
2004
)8-Dec-
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)8-Dec-
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1990
25-May-
1990
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1990
25-May-
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25-May-
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25-May-
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25-May-
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25-May-
1990
25-May-
1990
25-May-
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25-May-
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Correspondence and Supporting Material. 1990
105
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Miller, H. (1975) Phytotoxicity: Phototoxicity to Irrigated Crops. (Unpublished study „- -,
36539 received Jan 5, 1978 under 1F1105; submitted by Pennwalt Corp., Agchem Div., King of , „_„
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36543 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., , „_„
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36545 5, 1978 under 1F1105; prepared by Pharmacology Research, Inc., submitted by Pennwalt , „_„
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36549 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Pharmacology 05-Jan-
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Herbicide 273 in Albino Rabbits: IBT No. 8530- 08497. (Unpublished study received Jan 5, 05-Jan-
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Hydrothol 191 Liquid (N.B. 77-100-2) c) Hydrothol 47 Liquid (N.B. 77-100-3) d) Aquathol 1977
(N.B. 77-99-7) e) Des-I-Cate Accelerate (N.B. 77-99-6) f) Knox-Out 2 FM (N.B. 4414-94): 04-Oct-
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107
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(N.B. 77-100-4) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits:
36567 Laboratory No. 7E-5659. (Unpublished study received Jan 5, 1978 under 1F1105; prepared
by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div.; King of Prussia,
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36568 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories, , „_„
Inc., submitted by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL: 096704-AW)
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Granular (N.B. 77-99-4) on Abraded and Non-abraded Skin of New Zealand Albino „;- ^
36573 Rabbits: Laboratory No. 7E-5689. (Unpublished study received Jan 5, 1978 under 1F1105;
prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem Div., King
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Becker, J.; Parke, G.S.E. (1977) Report; The Effects of Aquathol Granular (N.B. 77-99-4)
on Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5688. (Unpublished 05-Jan-
study received Jan 5, 1980 under IF 1105; prepared by Cannon Laboratories, Inc., submitted 1978
by Pennwalt Corp., Agchem Div., King of Prussia, Pa.; CDL:096704-BC)
Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular
365?5 (N.B. 77-99-4) on New Zealand Albino Rabbits: Laboratory No. 7E-5687. (Unpublished 05-Jan-
study received Jan 5, 1978 under IF 1105; prepared by Cannon Laboratories, Inc., submitted 1978
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36576 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories,
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Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4) 2.
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36592 Hydout (N.B. 77-99-5): Laboratory Nos. 1. 7E-5690 2. 7E-5695 3. 7E-5700 4. 7E-5705. "
(Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon Laboratories,
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Eibert, J., Jr. (1966) Acute Oral Toxicity (LD50) Study in Rats: S.A. No. 106319. ,„
40959 (Unpublished study received Apr 10, 1966 under 6G0503; prepared by Scientific , „
Associates, Inc., submitted by Pennwalt Chemical Corp., Bryan, Tex.; CDL:090587-B)
Pennsalt Chemical Corporation (1964) Analysis of Endothall in Water by Gas-Liquid , „ .
40984 Chromatography. Method dated Apr 27, 1964. (Unpublished study received Apr 10, 1966 " £*~
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48110 Herbicides to Bluegill Sunfish. (Louisiana, Wildlife and Fisheries Commission, , „„„
unpublished study; CDL: 241577-R)
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48768 No' DACW65-74-c-°013- (Virginia Polytechnic Institute and State Univ., Dept. of 22-Aug-
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49958 (Compilation; unpublished study received Oct 5, 1976 under 4581-173; submitted by , „_,
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White, R.L.; Bounds,R.L.; Lowman, F.G.; et al. (1967) Experimental Control of __ ^
56036 Submerged Vegetation in Clear Water Lakes: Federal Aid Project No. F-2-R-14. (Texas, , „_,
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Pennwalt Corporation Endothall Technical. Tacoma, Wash.: Pennwalt. (Product data 01 F h
58568 bulletin no. 13c; also in unpublished submission received Feb 1, 1975 under 3F1416; , „_<-
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Albino Rabbits: Laboratory No. 7E-9262. (Unpublished study received Oct 26, 1978 under 26-Oct-
4581-282; pre-pared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., 1978
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Imlay, P. (1978) Report: The Acute Dermal LD50 of Dipotassium endothall on New
<-o721 Zealand Albino Rabbits: Laboratory No. 7E-9263. (Unpublished study received Oct 26, 26-Oct-
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61097 (Unpublished study received on unknown date under unknown admin, no.; CDL: 109 C890-
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109
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Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill
Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-16. (Unpublished 23-Jan-
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Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid
Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna Straus:
71138 UCES Project No. 11506-41-14. (Unpublished study received Jan 23, 1981 under 4581- ~™~
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Morton, H.L.; Moffett, J.O.; MacDonald, R.H. (1972) Toxicity of herbicides to newly 23-Jan-
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Landskov, A.O. (1981) Letter sent to Letha Coenen dated Feb 23, 1981: Compatibility- ~, M
71445 herbicide 273 tank mixes: Project No. WT-2- 81. (Unpublished study received Mar 25, , „„,
1981 under 4581-223; submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244661-A)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Bluegill
_..-_ Sunfish, Lepomis macrochirus-Rafinesque: UCES Project No. 11506-41-16. (Unpublished 23-Jan-
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Pennwalt Corporation (1980) Efficacy of Various Herbicides-Sugar- beet. (Compilation; __ M
74308 unpublished study received Mar 23, 1981 under ND 81/1; submitted by North Dakota, State
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Pennwalt Corporation (1976) Residue Study-Sugar Beet. (Compilation; unpublished study __
74309 received Mar 23,1981 under ND 81/1; submitted by North Dakota, State Laboratories & '"'".
Consumer Affairs for Pennwalt; CDL:244874-B)
Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology reports
on seven products. (Unpublished study received Jan 5, 1978under 4581-174; prepared by 05-Jan-
Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1978
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Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol K (N.B.
58-196-4). (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 05-Jan-
Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 1978
232580-E)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Aquathol Granular
78186 ^B' 58'196-7)- (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 05-Jan-
Pharmacology Re- search, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1978
CDL:232580-H)
110
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Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall
Products, Dermal Toxicity after Limited Expo- sure. (Unpublished study received Jan 5, 05-Jan-
1978 under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt 1978
Corp., Philadelphia, Pa.; CDL:232580-O)
Paa, H. (1976) Report to Pennwalt Corporation: Acute Dermal Toxicity Study with
?8198 Herbicide 273 in Albino Rabbits: IBT No. 8530- 08497. (Unpublished study received Jan 5, 05-Jan-
1978 under 4581-174; prepared by Industrial Bio-Test Laboratories, Inc., submitted by 1978
Pennwalt Corp., Philadelphia, Pa.; CDL:232580-V)
Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77-100-4); Hydrothol
191 Liquid (N.B. 77-100-2); Hydrothol 47 Liquid (N.B. 77-100-3); Aquathol (N.B. 77-99-
7); Des-i-cate Accelerate (N.B. 77-99-6); Knox- out 2 FM (N.B. 4414-94): Laboratory Nos. 05-Jan-
7E-5660; 7E-5665; 7F-5670; 7E-5675; 7E-5680; 7E-5685. (Unpublished study received Jan 1978
5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL: 232580-AB)
St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Aquathol K (N.B. 77-100-4) on
the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5658. (Unpublished 05-Jan-
study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 1978
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AG)
St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol
K (N.B. 77 -100-4) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits:
78208 Laboratory No. 7E-5659. (Unpublished study received Jan 5, 1978 under 4581-174; 1978"
prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL:232580-AH)
Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Aquathol K: Lab No. 7E-
78209 5656. (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL:232580-AJ)
St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Aquathol
Granular (N.B. 77-99-4) on Abraded and Non-abraded Skin of New Zealand Albino
78214 Rabbits: Laboratory No. 7E-5689. (Unpublished study received Jan 5, 1978 under 4581- "
174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia,
Pa.; CDL:232580-AO)
Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Aquathol Granular
(N.B. 77-99-4) on New Zealand Albino Rabbits: Laboratory No. 7E-5687. (Unpublished 05-Jan-
study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 1978
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AQ)
Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5686. Q5 J&n
78216 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AR)
Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4); 2.
Hydrothol 191 Granular (N.B. 77-99-2); 3. Hydrothol Granular (N.B. 77-99-3); 4. Hydout
78610 (N.B. 77-99-5): Laboratory Nos. 7E-5690; 7E- 5695; 7E-5700; 7E-5705. (Unpublished "
study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc.,
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BH)
04-Feb-
Pennsalt Chemicals Corporation (1954) Full Reports of Investigations Made with Respect
80437 to the Safety of the Product. (Unpublished study received Feb 4, 1966 under 6G0503;
CDL:090585-B) ,r^~
1966
81397 Pennwalt Corporation (1966) Toxicological Investigations, Mammals: Summary. Summary 14-Apr-
111
-------
of studies 051133-B through 051133 -M and 051133-R. (Unpublished study received Apr 1966
14, 1966 under 4581-70; CDL:051133-A)
Eibert, J., Jr. (1966) Acute Oral Toxicity (LDI50) Study in Rats: S.A. No. 106319. 14 A r
81407 (Unpublished study received Apr 14, 1966 under 4581 -70; prepared by Scientific , „/!-
Associates, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:051133-K)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout,
Salmo gairdneri Richardson: UCES Project No. 11506-41-15. (Unpublished study received 23-Jan-
Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt 1981
Corp., Philadelphia, Pa.; CDL:244131-C)
Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 25-Mar-
received Mar 25, 1981 under 4581 -223; CDL: 244664-A) 1981
25-Mar-
Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 1981
244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 14-Sep-
1981
Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxic Effects on __
83034 Non-target Plant Species: Project No. WT- 8-78. (Unpublished study received Mar 25, 1981 '
under 4581-223; CDL:244662-B)
Vilkas, A.J.; Seminara, J. (1979) The Acute Toxicity of Aquathol K to the Rainbow Trout,
Salmo gairdneri Richardson: UCES Project No. 11506-41-15. (Unpublished study received 23-Jan-
Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by Pennwalt 1981
Corp., Philadelphia, Pa.; CDL:099883-C)
Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid
Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna straus: __
83107 UCES Project No. 11506-41-14. (Unpublished study, including letter dated Feb 7, 1980
from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; prepared by
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-J)
Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Aquathol K 28.6% Acid
Equivalent Lot No. ACC-06M8-04, NB84-5-10 to the Water Flea, Daphnia magna straus:
84150 UCES Project No. 11506-41-14. (Unpublished study received Jan 23, 1981 under 4581 -
282; prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL:244122-J)
Pennwalt Corporation (19) Product Chemistry: Data Requirements. (Unpublished study 14-Sep-
received Sep 14, 1981 under 4581 -349; CDL: 246016-A) 1981
Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J , , „
84604 through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; ~~
CDL:246012-B)
Pennwalt Corporation (1975) Sub-acute Studies: Endothall. (Un- published study received 14-Sep-
Sep 14, 1981 under 4581-349; CDL: 246012-C) 1981
Pennwalt Corporation (1979) Oncogenicity Studies: Endothall. (Unpublished study received 14-Sep-
Sep 14, 1981 under 4581-349; CDL: 246012-F) 1981
Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. ,. „
84612 844059. (Unpublished study received Sep 14, 1981 under 4581-349; submitted by Pennwalt ~ ^'
Corp., Philadelphia, Pa.; CDL:246012-J)
Ralston Purina Company (1981) Aquathol Granular Aquatic Herbicide: RT Lab No. 14-Sep-
844057. (Unpublished study received Sep 14, 1981 under 4581-349; submitted by Pennwalt 1981
112
-------
Corp., Philadelphia, Pa.; CDL:246012-P)
Pennwalt Corporation (1981) Efficacy of Endothal on Turf. (Compilation; unpublished 14-Sep-
study received Sep 14, 1981 under 4581- 349; CDL:246013-A) 1981
Landolt, M.L.; Felton, S.P.; Liguon, V.M.; et al. (1981) Toxicity of Endothall to Juvenile
Chinook Salmon (Oncorhynchus tshawytscha). Final report (Washington, Dept. of Fisheries
84QQ1 f°r ^' ^' Army Corps of Engineers, Waterways Experiment Station, Aquatic Plant Control 21 -Oct-
Research Program; unpublished study, including published data and letters dated Aug 5, 1981
1981 from B.D. Gaughey to Gary Wedemeyer and Aug 27, 1981 from G.A. Wedemeyer to
BernalynD. McGaughey; CDL:246080-A)
Rosebery, G.D. (1981) Letter sent to Richard F. Mountfort dated Jul 20, 1981 Aquathol K
herbicide-Mutagenic and carcinogenic studies. Summary of studies 245680-B through 29-Jul-
245680-D. (Unpublished study received Jul 29, 1981 under 4581-204; submitted by 1981
Pennwalt Corp., Philadelphia, Pa.; CDL:245680-A)
Vigfusson, N. V. (1981) Evaluation of the Mutagenic Potential of Aquathol by the Induction
86690 °^ Bister Chromatid Exchanges in Human Lymphocytes in Vitro. Final report. (Unpublished 29-Jul -
study received Jul 29, 1981 under 4581-204; prepared by Eastern Washington Univ., Dept. 1981
of Biology, submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680-B)
Rundell, J.C.; Matthews, E.J. (1981) Evaluation of Aquathol K in the in Vitro
Transformation of B ALB/3 T3 Cells with and without Metabolic Activation Assay: LBI
86621 Project No. 20992. Final report. (Unpublished study, including letter dated May 8, 1981 t osi
from J.W. Tapp to Neil Peterson, received Jul 24, 1981 under 4581 -204; prepared by Litton
Bionetics, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:245680-C)
Folmar, L.C. (1976) Letter sent to Edward J. Bowles dated Jun 9, 1976 Results from
95819 toxicity tests conducted on rainbow trout fertilized eggs and sac fry with Aquathol K. (U. S. 05-Jan-
Fish and Wildlife Service, Bureau of Reclamation, Denver Fish-Pesticide Research Unit; 1978
unpublished study; CDL:096705-J)
Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity
96295 studies. (U.S. Fish and Wildlife Service, Fish Control Laboratory; unpublished study;
CDL:090719-G)
Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study
No. 69ISA. (Unpublished study received Sep 14, 1981 under 4581 -349; prepared by Food 14-Sep-
and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1981
CDL:246012-L)
Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study
No. 69ISA. (Unpublished study received Sep 14, 1981 under 4581 -349; prepared by Food 14-Sep-
and Drug Research Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1981
CDL:246012-M)
Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study
97833 Na 6915A- (Unpublished study received Sep 14, 1981 under 4581 -349; prepared by Food 14-Sep-
and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1981
CDL:246012-N)
Applied Biochemists, Incorporated (1973) Toxicity Data for Copper- triethanolamine ~, „
99204 Complex on Ring-necked Pheasant and Mallard Duck. (Unpublished study received Nov , „__
21, 1973 under 8959-12; CDL:010116-B)
Schmidt, J. (1974) Subacute Toxicities of Cutrine and Weedtrine-Plus to Ring-necked ,. ^
99448 Pheasants (Phasianus colchicus) & MallardDucks (Anus platyrhynchos): Dietary LC50. , „_,
(Unpublished study received Jun 14,1976 under 8959-11; submitted by Applied Bio -
113
-------
chemists, Inc., Mequon, WI; CDL:224874-B)
Reagan, E.L.; Becci, P.J.; Parent, R.A. (1981) Acute Oral Toxicity in Rats: FDRL Study
No. 69 ISA. (Unpublished study received Sep 14, 1981 under 4581 -349; prepared by Food 14-Sep-
and Drug Research Lab- oratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; 1981
CDL:246012-K)
Pennwalt Corp. (1982) Report to Pennwalt Corporation: Two-year Chronic Oral Toxicity
and Carcinogenic Study with Dipotassium Endothal Monohydrate or Disodium Endothal in 12-Aug-
Albino Rats. (Compilation; unpublished study received Aug 12, 1982 under 1F1 105; 1982
CDL:071035-A; 071036; 071037; 071038; 071039; 071040; 071041 071042; 071043)
Davis, J.; Hughes, J. (1963) Further Observations on the Toxicity of Commercial ,,, -,
1 13695 Herbicides to Bluegill Sunfish. (Louisiana, Wild Life and Fisheries Commission; , „_„
unpublished study; CDL: 098334-F)
Keckemet, O. (1975) The Results of Tests on the Amount of Residue Remaining, Including „„ ^ ,
1 1 3932 a Description of the Analytical Methods Used: Endothall. (Compilation; unpublished study , „_-
received Jul 9, 1975 under 1F1 105; CDL:094703-A; 094704)
Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 01-Dec-
(Compilation; unpublished study received Dec 1, 1970 under IF 1 105; CDL:094508-A) 1970
Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 01-Dec-
(Compilation; unpublished study received Dec 1, 1970 under 1F1 105; CDL:094507-A) 1970
Pennwalt Corp. (1972) Toxicity Study: Endothall on Rats & Fish. Summary of studies ,, ,.,
1 13938 094506-C and 094506-D. (Unpublished study received May 31, 1972 under 1F1 105; ~ Jly~
CDL:094506-B)
Van Duuren, B. (1972) Gastric Feeding in Rats: Beta-Propiolactone and Endothall. ^
1 1 3 93 9 (Unpublished study received May 3 1 , 1 972 under 1 F 1 1 05 ; prepared by New York Medical :
Center, submitted by Pennwalt Corp., Tacoma, WA; CDL:094506-C) '
28-Apr-
1972
Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, „ . ,,
1 13953 Including a Description of the Analytical Method Used: Endothall. (Compilation;
unpublished study received May 13, 1972 under IF 1 105; CDL:094506-H) 13 M
1972
Watson, J. (1971) Full Reports of Investigations Made with Respect to the Safety of the , , .
1 1 3959 Product: Endothall. (Unpublished study received Aug 1 1 , 1 97 1 under IF 1057; submitted by " ^f~
Pennwalt Corp., Tacoma, WA; CDL:091892-A)
Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of „,, ,,
1 1 397 1 the Product: Endothall. (Compilation; unpublished study received on unknown date under , „_ ,
1F1105; CDL:094509-A)
Agchem (1 970) The Results of Tests on the Amount of Residue Remain- ing Including a __ -,
1 1 3987 Description of the Analytical Method Used: Endothall. (Compilation; unpublished study , „_ ,
received Jun 27, 1971 under unknown admin, no.; CDL: 124882 -A)
Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and „„ ^ ,
1 14487 Complete Composition of the Product: Endothall. (Compilation; unpublished study received , „__
Jul 9, 1975 under 1F1105; CDL:094700-A)
Pennwalt Corp. (1 975) Full Reports and Data of Investigations Made on the Safety of the 09-Jul-
Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study 1975
114
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Folmar, L. (19) Letter sent to E. Bowles circa Dec 13, 1974 Aquathol K. (U.S. Dept. of the Q9 j j
114494 Interior, Bureau of Reclamation, Engineering and Research Center, Denver Fish Pesticide , „__
Unit; unpublished study; CDL:094702-K)
McCollum, K. (1973) Report toPennwalt Corporation: 21-day Sub- acute Oral Toxicity
114407 Study with Dipotassium Endothall and Disodium Endothall in Albino Rats: IBT No. 621- 09-Jul -
03463. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Industrial Bio- 1975
Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:094702-N)
Morrow, L. (1975) Report to ...: Two-year Chronic Oral Toxicity and Carcinogenic Study
with Dipotassium Endothall Monohydrate or Disodium Endothall in Albino Rats: IBT No. 09-Jul-
621-03115. (Unpublished study received Jul 9, 1975 under 1F1105; prepared by Industrial 1975
Bio-Test Laboratories, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:094702-O)
Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; 09-Jul-
unpublished study received Jul 9, 1975 under 1F1105; CDL:094706-A) 1975
Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 9, 09-Jul-
1975 under 1F1105; CDL:094706-B) 1975
Pennwalt Corp. (1974) Residues: Endothall. (Unpublished study received Jul 9, 1975 under 09-Jul-
1FH05; CDL:094706-C) 1975
Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study 09-Jul-
114;)U4 received Jul 9, 1975 under IF 1105; CDL: 094706-F) 1975
Agchem (1954) Toxicological Investigations—Mammals: Endothall. (Unpublished study 15-Mar-
received Mar 15, 1966 under 4581-139; CDL: 007441-A) 1966
Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several , _ ,,
114511 Pennsalt herbicides against rainbow trout. (U.S. Fish and Wildlife Service, Fish-Pesticide , „,,
Research Laboratory; unpublished study; CDL:007441 -K)
U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected , _ M
114513 Test Chemicals on Rainbow Trout, Goldfish, Black Bullhead, and Bluegill. (Unpublished , „,,
study; CDL:007441-M)
Agchem (1963) Study: Endothall Breakdown in the Environment. (Compilation; 15-Mar-
unpublished study received Mar 15, 1966 under 4581 -139; CDL:007441-AD) 1966
Keckemet, O. (1963) Letter sent to Ag. Chem. File dated Feb 11, 1963: Microbiological
breakdown of endothal weed killer & derivatives. (Unpublished study received Mar 15, 15-Mar-
1966 under 4581 - 139; submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; 1966
CDL:007441-AE)
Agchem (1972) Toxicity of Endothall in Animals. Summary of studies 095336-H, 094506- „ , M
114531 C and 094506-D. (Unpublished study received May 4, 1972 under 4581-284; CDL:095336- ~ *y~
C)
Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the , _ .
114540 Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15, , „_„
1970 under OF0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421-F)
Carlson, R.; Sandeno, J. (1970) Effect of Endothall on the Growth of Several Fungi. ?fi n t
114556 (Unpublished study received Oct 26, 1978 under 4581-282; submitted by Agchem Div., , „_„
Pennwalt Corp., Philadelphia, PA; CDL:235432-B)
Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study
received on unknown date under IF 1105; CDL:090872-A)
115
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Watson, J. (1972) Full Reports of Investigations Made with Respect to the Safety of the
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Duuren, B. (19) Gastric Feeding in Rats: beta-Propiolactone and Endothall. (Unpublished
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Mixon, W. (1971) Endothall Residue in Goldfish-Feeding Study. (Unpublished study
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Rock, L. (1963) Letter sent to unknown recipient dated Jan 8, 1963 Potassium Endothal:
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McCann, J. (1969) Aquathol Plus Granular: Bluegill (Lepomis macrochirus). (U.S.
Agricultural Research Service, Pesticides Regulation Div., Animal Biology Laboratory;
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Agchem (1970) Some Additional Information Pertaining to Fate of Endothall in the
Environment: Summary. (Unpublished study received Dec 1, 1970 under 1F1105;
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Rodgers, J.; Reinert, K.; Hinman, M.; et al. (1983) Water Quality Monitoring in
Conjunction with the Pat Mayse Lake Aquatic Plant Program. (Unpublished study received
Mar 23, 1984 under 4581- 201; prepared by North Texas State Univ., Institute of Applied
Sciences and Dept. of Biological Sciences, submitted by Agchem Div., Pennwalt Corp.,
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Mixon, W. (1971) Endothall Residue in Goldfish-Feeding study. (Unpublished study
received May 31, 1972 under 1F1105; submitted by Pennwalt Corp., Tacoma, WA;
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Serns, S. (1974) The Effects of a Dipotassium Endothall Treatment on the Ecology of a
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Folmar, L. (1976) Overt avoidance reaction of rainbow trout fry to nine herbicides. Bulletin
of Environmental Contamination & Toxicology 15(5):509-514. (Also In unpublished
submission received Feb 6, 1984 under 239-2424; submitted by Chevron Chemical Co.,
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unpublished submission received Feb 6, 1984 under 239-2424; submitted by Chevron
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Strange, J. (1983) IBT Validation Report-Endothall Two-year Chronic Oral Toxicity and
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Armondi, S. (1991) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with
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study prepared by Springborn Laboratories, Inc. 61 p.
Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Marine Diatom,
Skeletonema costatum: Final Report: Lab Project Number: 92-1-4063. Unpublished study
prepared by Springborn Laboratories, Inc. 60 p.
Hoberg, J. (1992) Dipotassium Salt of Endothall--Determination of Effects on Seed
Germination, Seedling Emergence and Vegetative Vigor of Ten Plant Species: Final
Report: Lab Project Number: 91-11-4015: 12442.0391.6117.610: BR-91-55. Unpublished
study prepared by Springborn Laboratories, Inc. 353 p.
Hoberg, J. (1992) Dipotassium Salt of Endothall--Toxicity to the Duckweed Lemna gibba:
Final Report: Lab Project Number: 92-2-4097: 12442.0391.6118.410: BR-91-54.
Unpublished study prepared by Springborn Laboratories, Inc. 45 p.
Atochem North America (1992) Submission of Toxicity Data in Support of the
Reregistration of Aquathol K. Transmittal of 2 studies.
Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Aquathol K in the Rat: Lab
Project Number: 91/8357. Unpublished study prepared by Bio/dynamics, Inc. 133 p.
Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Pelletized Aquathol K in the
Rat: Lab Project Number: 91-8345: Unpublished study prepared by Bio/dynamics, Inc. 124
P-
Atochem North America (1992) Submission of exposure data in support of the Phase 4
requirements for Endothall. Transmittal of 1 study.
Baugher, D.; Meikle, S. (1992) Field Spray Drift Evaluation of Endothall (Accelerate
Herbicide) Results of Wind Tunnel Testing of Aerial and Airblast Application Nozzles: Lab
Project Number: 32389: BR-89-48: 55-END/92028. Unpublished study prepared by Orius
Associates, Inc. 152 p.
Elf Atochem North America, Inc. (1992) Submission of toxicity data in support of the
reregistration of Endothall, K-Salt. Transmittal of 1 study.
Margitich, D.; Ackerman, L. (1992) 21 Day Dermal Toxicity Study in Rats: Aquathol K:
Lab Project Number: PH 430-ANA-002-91. Unpublished study prepared by Pharmakon
Research International, Inc. 330 p.
Atochem North America, Inc. (1993) Submission of environmental data in support of the
data call-in for endothal acid. Transmittal of 1 study.
Reynolds, J. (1992) Aerobic Aquatic Metabolism of (carbon 14)-Endothall Dipotassium
Salt: Lab Project Number: XBL 91024: RPT0083: BR-91-46. Unpublished study prepared
by XenoBiotic Labs, Inc. 81 p.
Elf Atochem N.A., Inc. (1993) Submission of product chemistry data in support of the data
call-in for Endothall, K Salt. Transmittal of 1 study.
Sweetapple, G. (1992) Dipotassium Endothall--Color, Physical State, Odor, Melting Point,
Bulk Density, pH: Lab Project Number: 4200-92-0335-AS: 4200-92-0335-AS-001.
Unpublished study prepared by Ricerca, Inc. 36 p.
42644000 Atochem North America, Inc. (1993) Submission of environmental fate data to support
13-Jul-
1992
13-Jul-
1992
13-Jul-
1992
13-Jul-
1992
13-Jul-
1992
20-Jul-
1992
20-Jul-
1992
20-Jul-
1992
05-Aug-
1992
05-Aug-
1992
02-Oct-
1992
02-Oct-
1992
08-Jan-
1993
08-Jan-
1993
21-Jan-
1993
21-Jan-
1993
28-Jan-
118
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Endothall reregistration. Transmittal of 1 study.
1993
42644001
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42695403
42695404
42695405
42695406
42787700
42787701
42787702
42792700
42792702
Dionne, E. (1992) Dipotassium Salt of Endothall: Bioconcentration and Elimination of
(carbon 14)-residues with Bluegill Sunfish: Final Report: Lab Project Number: 92-5-4269:
12442.0391.6115.140. Unpublished study prepared by Springborn Labs, Inc. 92 p.
Elf Atochem N.A., Inc. (1993) Submission of environmental fate data in support of the
Endothall (K Salt) data call-in. Transmittal of 1 study.
Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (Herbicide 273 Sugar
Beet Herbicide) Applied to Sugar Beets: Lab Project Number: WT-2-85: BR-92-53.
Unpublished study prepared by Pennwalt Corp. 223 p.
Elf Atochem (1993) Submission of toxicity data in support of the data call-in for Endothall,
K Salt. Transmittal of 6 studies.
Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)—Acute Toxicity to
Bluegill Sunfish (Lepomis macrochirus) under Flow-through Conditions: Final Report: Lab
Project Number: 92-3-4192: 1244.0591.6133.105. Unpublished study prepared by
Springborn Labs, Inc. 62 p.
Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)—Acute Toxicity to
Rainbow Trout (Oncorhynchus mykiss) under Flow-through Conditions: Final Report: Lab
Project Number: 92-3-4163: 12442.0591.6132.108. Unpublished study prepared by
Springborn Labs, Inc. 63 p.
Putt, A. (1993) Aquathol K (Dipotassium Salt of Endothall)-Acute Toxicity to Daphnids
(Daphnia magna) under Flow-through Conditions: Final Report: Lab Project Number: 92-3-
4153: 12442.0591.6134.115. Unpublished study prepared by Springborn Labs, Inc. 69p.
Dionne, E. (1993) Aquathol K (Dipotassium Salt of Endothall)--Acute Toxicity to Eastern
Oyster (Crassostrea virginica) under Flow-through Conditions: Final Report: Lab Project
Number: 92-3-4149: 12442.0591.6137.504. Unpublished study prepared by Springborn
Labs, Inc. 66 p.
Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)-Acute Toxicity to
Sheepshead Minnow (Cyprinodon variegatus) under Flow-through Conditions: Final
Report: Lab Project Number: 92-2-4110: 12442.0591.6135.505. Unpublished study
prepared by Springborn Labs, Inc. 64 p.
Bettencourt, M. (1993) Aquathol K (Dipotassium Salt of Endothall)—Acute Toxicity to
Mysid Shrimp (Mysidopsis bahia) under Flow-through Conditions: Final Report: Lab
Project Number: 92-9-4411: 12442.0591.6136.515. Unpublished study prepared by
Springborn Labs, Inc. 66 p.
Elf Atochem North America, Inc. (1993) Submission of product chemistry data in support
of the reregistration for Endothall, K Salt. Transmittal of 2 studies.
Wojcieck, B. (1993) Aquathol Granular-Color, Physical State, Odor, Bulk Density, pH:
Lab Project Number: 4200-92-0178-AS: 4200-92-0178-AS-001. Unpublished study
prepared by Ricerca, Inc. 37 p.
Gallacher, A. (1993) Dipotassium Endothall-Dissociation Constant: Lab Project Number:
4200-92-0324-AS: 4200-92-0324-AS-001. Unpublished study prepared by Ricerca, Inc. 54
P-
Elf Atochem North America, Inc. (1993) Submission of metabolism data in response to DCI
for Endothall Acid (Technical). Transmittal of 2 studies
28-Jan-
1993
18-Feb-
1993
18-Feb-
1993
15-Mar-
1993
15-Mar-
1993
15-Mar-
1993
15-Mar-
1993
15-Mar-
1993
15-Mar-
1993
15-Mar-
1993
26-May-
1993
26-May-
1993
26-May-
1993
01-Jun-
1993
Reynolds, J. (1993) Aerobic Soil Metabolism of (carbon 14)-Endothall Dipotassium Salt: 01-Jun-
119
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43081801
43081802
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Lab Project Number: XBL 91023: RPT00115: BR-91-44. Unpublished study prepared by
XenoBiotic Labs., Inc. 91 p.
Elf Atochem North America, Inc. (1993) Submission of additional range finding toxicity
data in support of reregistration for Endothall K Salt. Transmittal of 1 study.
Margitich, D.; Ackerman, L. (1992) Aquathol K: 21 Day Dermal Toxicity Study in Rats:
Lab Project Number: PH 430-ANA-001-91. Unpublished study prepared by Pharmakon
Research International, Inc. 275 p.
Elf Atochem North America, Inc. (1993) Submission of Product Chemistry Data in Support
of Reregistration of Endothall K Salt. Transmittal of 1 Study.
Wojcieck, B. (1993) Aquathol K: Color, Physical State, Odor, Specific Gravity, pH,
Viscosity: Lab Project Number: 4200-92-0176-AS: 4200-92-0176-AS-001. Unpublished
study prepared by Ricerca, Inc. 46 p.
Elf Atochem North America, Inc. (1993) Submission of Metabolism Data for (Carbon 14)-
Endothall Dipotassium Salt in Support of Reregistration. Transmittal of 1 Study.
Reynolds, J. (1993) Anaerobic Aquatic Metabolism of (Carbon 14C)-Endothall
Dipotassium Salt: Lab Project Number: XBL 91025: RPT00116: BR-91-45. Unpublished
study prepared by XenoBiotic Lab., Inc. 106 p.
Elf Atochem North America, Inc. (1993) Submission of product chemistry data in response
to DCI for reregistration of endothall dipotassium salt. Transmittal of 2 studies.
Sweetapple, G. (1993) Aquathol K--Corrosion Characteristics: Lab Project Number:
4200/92/0177/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p.
Sweetapple, G. (1993) Aquathol Granular—Corrosion Characteristics: Lab Project Number:
4200/92/0179/AS/001. Unpublished study prepared by Ricerca, Inc. 35 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Aquathol K
Aquatic Herbicide in Support of Reregistration Data Call-in. Transmittal of 2 studies.
Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8-Day Acute Dietary LC50 Study in
Bobwhite Quail: Lab Project Number: 106-013-01: HWA 153-150. Unpublished study
prepared by Bio-Life Associates, Ltd. 102 p.
Pedersen, C. (1994) Aquathol K Aquatic Herbicide: 8-Day Acute Dietary LC50 Study in
Mallard Ducklings: Lab Project Number: 106-017-02: HWA 153-150. Unpublished study
prepared by Bio-Life Associates, Ltd. 97 p.
Elf Atochem North America, Inc. (1994) Submission of product chemistry (stability) data in
support of reregistration of Endothall, K-salt. Transmittal of 1 study.
Malone, S. (1994) Dipotassium Endothall TG (B46-50): Stability: Lab Project Number:
4200/92/0327/AS/001. Unpublished study prepared by Ricerca, Inc. 57 p.
Elf Atochem North America, Inc. (1994) Submission of exposure assessment data in
support of DCI for reregistration of endothall. Transmittal of 1 study.
Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for
Endothall Potassium and Amine Salt Formulation: Lab Project Number: EA070594.
Unpublished study prepared by Jellinek, Schwartz & Connolly, Inc. 82 p.
Elf Atochem North America, Inc. (1994) Submittal of Environmental Fate Data in Support
of Registration Standard for Endothall. Transmittal of 1 study.
1993
18-Jun-
1993
18-Jun-
1993
16-Aug-
1993
16-Aug-
1993
31-Aug-
1993
31-Aug-
1993
11-Jan-
1994
11-Jan-
1994
11-Jan-
1994
22-Mar-
1994
22-Mar-
1994
22-Mar-
1994
10-Jun-
1994
10-Jun-
1994
12-Jul-
1994
12-Jul-
1994
26-Jul-
1994
Dionne, E. (1994) Metabolism of Endothall Dipotassium Salt in Bluegill Sunfish (Lepomis 26-Jul-
120
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macrochirus): Identification and Characterization of Metabolites in Fillet and Viscera: Lab
Project Number: 12442.0391.6115.180: BR-91-53: 94-2-5168. Unpublished study prepared
by Springborn Labs, Inc. and XenoBiotic labs Inc. 155 p.
Elf Atochem North America, Inc. (1994) Submission of Exposure Data in Support of
Endothall Reregistration. Transmittal of 1 Study.
Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol- and
Hydrothol- Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwartz,
and Connolly, Inc. lip.
Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistry
Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies.
Lorence, P. (1994) Dipotassium Endothall--Octanol/Water Partition Coefficient: Lab
Project Numbers: 4200-92-0256-AS: 4200-92-0256-AS-001. Unpublished study prepared
by Ricerca, Inc. 51 p.
Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in Support
of the Reregistration of Dipotassium Salt of Endothall. Transmittal of 1 Study.
Lorence, P. (1994) Dipotassium Endothall--Solubility: Lab Project Numbers: 4200-92-
0257-AS: 4200-92-0257-AS-001: 4200-92-0257-AS-000. Unpublished study prepared by
Ricerca, Inc. 67 p.
Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in Support
of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic
Algicide and Herbicide. Transmittal of 2 Studies.
Lincks, G. (1994) Aquathol K Aquatic Herbicide Manufacturing Process: Lab Project
Number: QC0006RO.QTR. Unpublished study prepared by Elf Atochem North America,
Inc. 27 p.
Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support
of the Amended Registration of HERBICIDE 273 Sugar Beet Herbicide. Transmittal of 1
Study.
Lincks, G. (1994) Herbicide 273 Sugar Beet Herbicide Manufacturing Process: Lab Project
Number: QC0008RO.QTR. Unpublished study prepared by Elf Atochem North America,
Inc. 27 p.
Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in Support
of the Amended Registration of Aquathol Granular Aquatic Herbicide. Transmittal of 1
Study.
Lincks, G.; Parker, I; Wright, J. (1994) Aquathol Granular Aquatic Herbicide
Manufacturing Process: Lab Project Number: QC0011RO.QTR. Unpublished study
prepared by Elf Atochem North America, Inc. 23 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall and Salts. Transmittal of 2 Studies.
Ussary, J. (1996) Endothall: Magnitude of the Residue in Sugar Beet Processing Fractions:
Final Report: Lab Project Number: BR-90-10: 53-90: 53A-90. Unpublished study prepared
by Elf Atochem North America, Inc.; McKenzie Labs; and Oaks Experimental Farm. 178 p.
Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate
Data in Support of the Reregistration of Endothall and its Salts. Transmittal of 3 Studies.
Ritter, A.; Williams, W. (1996) Aquathol-K: The Rate of Dissipation of Endothall as a
Result of Degradation versus Dilution: Lab Project Number: WEI 286.03: ATO BR-94-17:
1994
02-Dec-
1994
02-Dec-
1994
06-Dec-
1994
06-Dec-
1994
25-Jan-
1995
25-Jan-
1995
13-Dec-
1995
13-Dec-
1995
29-Mar-
1996
29-Mar-
1996
14-Mar-
1996
14-Mar-
1996
18-Jun-
1996
18-Jun-
1996
26-Aug-
1996
26-Aug-
1996
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44263505
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44263507
44263508
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44319601
44319602
BR-94-17. Unpublished study prepared by Waterborne Environmental, Inc.; Springborn
Labs., Inc.; and McKenzie Labs. 225 p.
Biever, R. (1996) Aquathol K: An Aquatic Dissipation Study for Aquatic Non-Crop Uses:
Lab Project Number: 95-06-5898: 12442-0894-6181-330: BR-94-13. Unpublished study
prepared by Springborn Labs., Inc. and McKenzie Labs., Inc. 375 p.
Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in
Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies.
Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Orange RAC: (Final
Report): Lab Project Number: BR-90-58: BR-90-58-1. Unpublished study prepared by
McKenzie Labs, Inc. 109 p.
Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Tomato RAC: Lab
Project Number: BR-90-59: BR-90-59-1. Unpublished study prepared by McKenzie Labs,
Inc. 105 p.
Carr, B.; Amo s, L. (1997) Frozen Storage Stability of Endothall Residues in Broccoli RAC:
(Final Report): Lab Project Number: BR-90-50: BR-90-50-1. Unpublished study prepared
by McKenzie Labs, Inc. 125 p.
Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Rice RAC: (Final
Report): Lab Project Number: BR-90-51: BR-90-51-1. Unpublished study prepared by
McKenzie Labs, Inc. 129 p.
Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-02: 70-91:
70A-91. Unpublished study prepared by McKenzie Labs, Inc. 237 p.
Toth, J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR-91-04: 74-91: 74A-91.
Unpublished study prepared by McKenzie Labs, Inc. 224 p.
Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-05: 73-91:
73A-91. Unpublished study prepared by McKenzie Labs, Inc. 223 p.
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the
Reregistration for Endothall Acid & Salts. Transmittal of 1 Study.
Carr, B. (1997) Frozen Storage Stability of Endothall Residues in Spinach RAC: Lab
Project Number: BR-90-52: BR-90-52-1. Unpublished study prepared by McKenzie
Laboratories, Inc. 112 p.
Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity
Data in Support of the Application for Registration for Thin-Rite Blossom Thinner.
Transmittal of 10 Studies.
Parker, J. (1997) Thin-Rite Apple Blossom Thinner: Product Chemistry: (Product Identity
and Composition): Lab Project Number: QC0018RO.QTR. Unpublished study prepared by
Elf Atochem North America, Inc. 30 p. {OPPTS 830.1600, 830.1620, 830.1670}
Parker, J. (1997) Thin-Rite Apple Blossom Thinner: Product Chemistry: (Physical and
Chemical Characteristics). Unpublished study prepared by Elf Atochem North America,
Inc. 5 p.
26-Aug-
1996
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
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Wright, J. (1997) ThmRite-Color, Physical State, Odor, Density, and pH: (Draft Final
Report): Lab Project Number: QC9707AO.QTR: KP-97-07. Unpublished study prepared by
Elf Atochem North America, Inc. 32 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300,
830.7000}
Wright, J. (1997) ThinRite--Determination of Viscosity: (Draft Final Report): Lab Project
Number: QC9712AO. QTR: KP-97-12. Unpublished study prepared by Elf Atochem North
America, Inc. 21 p. {OPPTS 830.7100}
Wnorowski, G. (1997) Acute Oral Toxicity Defined LD50 (in Rats): ThinRite: Lab Project
Number: 5071: P320. Unpublished study prepared by Product Safety Labs. 25 p.
Wnorowski, G. (1997) Acute Dermal Toxicity Limit Test (in Rabbits): ThinRite: Lab
Project Number: 5072: P322. Unpublished study prepared by Product Safety Labs. 16 p.
Wnorowski, G. (1997) Acute Inhalation Toxicity Limit Test (in Rats): ThinRite: Lab
Project Number: 5076: P330. Unpublished study prepared by Product Safety Labs. 24 p.
Wnorowski, G. (1997) Primary Eye Irritation (in Rabbits): ThinRite: Lab Project Number:
5073: P324. Unpublished study prepared by Product Safety Labs. 22 p.
Wnorowski, G. (1997) Primary Skin Irritation (in Rabbits): ThinRite: Lab Project Number:
5074: P326. Unpublished study prepared by Product Safety Labs. 17 p.
Wnorowski, G. (1997) Dermal Sensitization Test—Buehler Method (in Guinea Pigs):
ThinRite: Lab Project Number: 5075: P328. Unpublished study prepared by Product Safety
Labs. 24 p.
Elf Atochem North America, Inc. (1997) Submission of Product Chemistry and Toxicity
Data in Support of the Application for Registration of Aquathol Super K Granular Aquatic
Herbicide. Transmittal of 8 Studies.
Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry: Lab
Project Number: QC0017RO.QTR. Unpublished study prepared by Elf Atochem North
America. 25 p. {OPPTS 830.1620, 830.1670}.
Parker, J. (1997) Aquathol Super K Granular Aquatic Herbicide: Product Chemistry
(Physical Chemical Characteristics). Unpublished study prepared by Elf Atochem North
America. 5 p.
Gibson, K. (1997) Aquathol Super K-Color, Physical State, Odor, Bulk Density, pH: Lab
Project Number: QC9617AO.QTR: KP-96-17. Unpublished study prepared by Elf Atochem
North America, Inc. 28 p. {OPPTS 830.6302, 830.6303, 830.6304, 830.7300, 830.7000}.
Wnorowski, G. (1996) Acute Oral Toxicity Defined LD50 (in Rats): Aquathol Super K
Granule: Lab Project Number: 4878: P320. Unpublished study prepared by Product Safety
Labs. 26 p.
Wnorowski, G. (1996) Acute Dermal Toxicity Limit Test (in Rabbits): Aquathol Super K
Granule: Lab Project Number: 4879: P322. Unpublished study prepared by Product Safety
Labs. 15 p.
Wnorowski, G. (1996) Primary Eye Irritation (in Rabbits): Aquathol Super K Granule: Lab
Project Number: 4880: P324. Unpublished study prepared by Product Safety Labs. 23 p.
Wnorowski, G. (1996) Primary Skin Irritation (in Rabbits): Aquathol Super K Granule: Lab
Project Number: 4881: P326. Unpublished study prepared by Product Safety Labs. 16 p.
Wnorowski, G. (1996) Dermal Sensitization Test (in Guinea Pigs)--Buehler Method:
Aquathol Super K Granule: Lab Project Number: 4882: P328. Unpublished study prepared
by Product Safety Labs. 24 p.
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
03-Jul-
1997
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1997
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1997
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44408801
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of Petition 03-Jul-
for Tolerance for Endothall on Apples. Transmittal of 3 Studies. 1997
Ussary, J. (1997) Endothall: Magnitude of the Residue in Apples Treated with TD-2337, A
New Blossom Thinner Use: Final Report: Lab Project Number: BR-95-05: 05-95: 05A-95. 03-Jul-
Unpublished study prepared by Ussary Scientific Services, Inc.; ABC labs, Inc.; and Elf 1997
Atochem N.A., Inc. 213 p.
Leppert, B.; Sharp, J. (1997) Magnitude of Residues of Endothall as TD-2337-03 Blossom
Thinner in Apple Processed Fractions: (Final Report): Lab Project Number: KP-96-06: 03-Jul-
SARS-96-ID-80: SARS-96-WA-80A. Unpublished study prepared by Stewart Agricultural 1997
Services, Inc. and Elf Atochem N.A., Inc. 164 p.
Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number: 03-Jul-
FQPA 697E. Unpublished study prepared by Elf Atochem N. A., Inc. 42 p. 1997
Elf Atochem N.A., Inc. (1997) Submission of Residue Data in Support of the Reregistration 25-Jul-
of Endothall Acid and Salts. Transmittal of 1 Study. 1997
Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Cabbage with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 25-Jul-
Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR-91-01: 71A-91: 71B-91. 1997
Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241 p.
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the 06-Aug-
Reregistration for Endothall Acid & Salts. Transmittal of 1 Study. 1997
Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Turnips with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or 06-Aug-
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Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191
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36558 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon
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CDL: 096704-AK)
Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Liquid (N.B. 77-
100-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5663. „- ^
36559 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon
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129
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Pierre, F.S.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Hydrothol
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Becker, I; Parke, G.S.E. (1977) Report: The Effects of Hydro- thol 191 Granular (N.B.
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Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LDI50 of Hydrothol 191
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36579 (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon
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Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Hydout TM (N.B. 77-99-5) on
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36586 Laboratory No. 7E- 5704. (Unpublished study received Jan 5, 1978 under 1F1105; i QTS"
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Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout TM (N.B.
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Pierre, F.S.; Parke, G.S.E. (1977) Report: The Effects of Des-I-Cate /Accelerate (N.B. 77-
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36590 5677. (Unpublished study received Jan 5, 1978 under 1F1105; prepared by Cannon
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36592 Hydout (N.B. 77-99-5): Laboratory Nos. 1. 7E-5690 2. 7E-5695 3. 7E-5700 4. 7E-5705. 05-Jan-
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37848 Albino Rabbits: Laboratory No. 7E-5679. (Unpublished study received Jan 5, 1978 under
1F1 105; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Agchem
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42004 Amine Endothall with Def and Folex. (Unpublished study received Apr 10, 1966 under
6G0503; submitted by Pennsalt Chemical Corp., Bryan, Tex.; CDL:090587-AD)
Wakatsuki, J.; Wachi, G.; Oudman, L.; et al. (1975) Ripenthol Reports. (Reports by 71 o t
46489 various sources; unpublished study received Oct 21, 1975 under 4581-EX-19; submitted , „__
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Pennwalt Corporation (1966) Toxicity Study: Hydrothal on Fish. (Reports by various ,- -,
49658 sources; unpublished study received Jun 25, 1 97 1 under unknown admin, no. ; , „_ ,
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51466 (Louisiana, Wild Life and Fisheries Commission, Aquatic Vegetation Control Research, , „_,
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Frank, P. A. (1 964) Letter sent to Edward J. Bowles dated Oct 30, 1 964 Hydrothol
51467 treatment of aquatic weeds. (U.S. Agricul- tural Research Service, Crops Research Div., , „_,
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51468 weeds and fish. (Ohio, Div. of Wildlife, Dept. of Natural Resources, unpublished study; , „_,
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51 589 findings with alcoholic Ripenthol and aqueous Ripenthol. (Unpublished study received 1976
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52823 Seaman, D.E.; De Witt, J.R.; Beeman, H.D., Jr.; et al. (1975) Re- ports of Experimental 16-Oct-
131
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05-Jan-
1972
08-Feb-
1973
Frank, P.A.; Comes, R.D. (1967) Herbicidal residues in pond water and hydrosoil. Weeds .. ,
04-An^-
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21-Dec-
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58567 Rice Herbicide. Method dated May 1973. (Un- published study received Feb 1, 1975 '
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Pennsalt Chemicals Corporation (1968) Product Specification 5-9224. (Unpublished study oi F b
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Pennwalt Corporation (1973) Efficacy of Hydrothol 191 on Rice. (Compilation; 01 F b
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132
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67074 Hydrothol 191 Granular (Hydrothol 191 Rice Herbicide) and Herbicide 283. Method 01-Feb-
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Pennsalt Chemicals Corporation (1968) Hydrothol 191 Rice Herbicide: Product 01 F b
67025 Specification 5-9224. (Unpublished study received Feb 1, 1975 under 458l-EX-21; 1975
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67725 (Compilation; unpublished study received May 8, 1967 under 7G0608; submitted by , „,_
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69052 79-4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to 23-Jan-
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Pennwalt Corporation (1979) Fish and Wildlife Safety Summary. Summary of studies __ -,
71130 244131-B through 222131-R. (Unpublished study received Jan 23, 1981 under 4581-174; "
CDL:244131-A)
Vilkas, A.G.; Semmara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow
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received Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by 1981
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Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd- out(TM) Aquatic Weed
?1 ™ Killer Code AHE 09H901, N.B. No. 84-112-1 to the Rainbow Trout Salmo gairdneri 23-Jan-
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B.D. McGaughey, received Jan 23, 1981 under 4581 -174; prepared by Union Carbide
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Killer Code AHE 09H901, N.B. No. 84-112-1 to the Bluegill Sunfish, Lepomis
-,,,,,- macrochirus Rafinesque: UCES Project No. 11506-41-19. (Unpublished study, including 23-Jan-
letter dated Feb 7, 1980 from O. Keckemet to AgchemFile, received Jan 23, 1981 under 1981
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Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active)
(Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphma magna Straus:
71139 UCES Project No. 11506-41-22. (Unpublished study, including letter dated Feb 7, 1980
from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581- 174; prepared by
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-K)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient
to the Grass Shrimp Palaemonetes pugio: USES Project No. 11506-41-23. (Unpublished
71140 study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan
23, 1981 under 4581-174; prepared by Union Carbide Corp., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:244131-M)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer
Code AHE 09H901, N.B. No. 84-112-1 to the Fiddler Crab, Uca pugilator: UCES Project
?1141 No. 11506-41-24. (Unpublished study, including letters dated Jan 18, 1980 from A.G. 23-Jan-
Vilkas to B.D. McGaughey and Feb 7, 1980 from O. Keckemet to Agchem File, received 1981
Jan 23, 1981 under 4581-174; pre- pared by Union Carbide Corp., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:244131-N)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient
to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506- __ ^
71144 41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to \' ™~
Agchem File, received Jan 23, 1981 under 4581-174; prepared by Union Carbide Corp.,
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244131-Q)
Hestand, R.S., III (1974) Letter sent to Johnnie L. Frizzell dated Sep 27, 1974 Rough data
on efficacy and toxicity of TD-1874 and Hydrothol 191. (Florida, Game and Fresh Water 23 -Jan-
Fish Comission; unpublished study, including letter dated Sep 26, 1974 from R.S. 1981
Hestand, III to Johnnie L. Frizzell; CDL:244131-T)
U.S. Department of Interior, Bureau of Reclamation (1963) Results of Algaecidal __ ^
71147 Evaluation Tests of Selected Compounds: Report No. WC-21. (Pages 26-32 only in -go-
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Pennwalt Corporation (1980) Hydout Aquatic Algicide and Herbicide--Pellet State versus __ -,
71148 Toxicity: Project No. WT-4-80. (Unpublished study received Jan 23, 1981 under 4581- ''
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Pennwalt Corporation (1978) Residue Chemistry: Results of Residue Determinations. 23-Jan-
(Unpublished study received Jan 23, 1981 under 4581-282; CDL:244121-A) 1981
Pennwalt Corporation (1979) Hydout Aquatic Herbicide--Release Rate: ProjectNo. WT- 23-Jan-
13-79. (Unpublished study received Jan 23, 1981 under 4581-282; CDL:244121-B) 1981
134
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Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow
Trout, Salmo gairdneri Richardson: UCES Project No. 11506-41-17. (Unpublished study 23-Jan-
received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted by 1981
Pennwalt Corp., Philadelphia, Pa.; CDL:099883-D)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill
79458 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-18. (Unpublished 23-Jan-
study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp.; submit- ted 1981
by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-G)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer
Code AHE 09H901, N.B. No. 84-112-1 to the Bluegill Sunfish Lepomis macrochirus
Rafinesque: UCES Project No. 11506-41-19. (Unpublished study, including letter dated 23-Jan-
Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 1F1105; 1981
prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL: 099883-H)
Vilkas, A.G.; Hughes, J.S. (1979) The Acute Toxicity of Endothall (Acid Monohydrate)
to the Water Flea Daphnia magna Straus: UCES Project No. 11506-41-09. (Unpublished 23-Jan-
study received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp., submitted 1981
by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-I)
Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active)
(Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphnia magna Straus:
72461 UCES Project No. 11506-41-22. (Unpublished study received Jan 23, 1981 under 1F1105; ~~
prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL: 099883-K)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient
to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506-41-23. (Unpublished
72462 study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan
23, 1981 under 1F1105; prepared by Union Car-bide Corp., submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL: 099883-M)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hyd-out Aquatic Weed Killer
Code AHE 09H901, N.B. No. 84-112-1 to the Fiddler Crab, Uca pugilator: UCES Project
No. 11506-41-24. (Unpublished study, including letters dated Feb 7, 1980 from O. 23-Jan-
Keckement to Agchem File and Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey, 1981
received Jan 23, 1981 under IF 1105; prepared by Union Carbide Corp., submitted by
Pennwalt Corp., Philadelphia, Pa.; CDL:099883-N)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient
to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project No. 11506- __ -,
72466 41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. Keckemet to
Agchem File, received Jan 23, 1981 under 1F1105; prepared by Union Carbide Corp.,
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:099883-Q)
Pennwalt Corporation (1980) Efficacy Introduction: Hydout Aquatic Algicide and __ -,
72550 Herbicide. (Compilation; unpublished study received Jan 23, 1981 under 4581 -EX-32; , „„,
CDL:244117-A)
Moreno, M.T.; Moreno, O.M. (1979) Test for Guinea Pig Sensitiza-tion: Project No. MB
79-4140. (Unpublished study, including letter dated Dec 19, 1979 from O.M. Moreno to 23-Jan-
Obren Keckemet, received Jan 23, 1981 under 4581-174; prepared by MB Research 1981
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244123-C)
Vilkas, A.G.; Browne, A.M. (1979) The Acute Toxicity of Hydout (22.6% Active) 23 J&n
74221 (Sample Code 84-112-1; Lot AHE 09H9-01) to the Water Flea Daphnia magna Straus: ~~
UCES Project No. 11506-41-22. (Unpublished study, including letter dated Feb 7, 1980
135
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from O. Keckemst to Agchem File, received Jan 23, 1981 under 4581- 282; prepared by
Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-K)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active Ingredient
to the Grass Shrimp Palaemonetes pugio: UCES Project No. 11506-41-23. (Unpublished
74222 study, including letter dated Feb 7, 1980 from O. Keckemet to Agchem File, received Jan
23, 1981 under 4581 -282; prepared by Union Carbide Corp., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:244122-M)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hy-dout Aquatic Weed Killer,
Code AHE 09H901, N.B. No. 84- 112-1, to the Fiddler Crab, Uca pugilator: UCES
Project No. 11506-41-24. (Unpublished study, including letters dated Jan 18, 1980from 23-Jan-
A.G. Vilkas to B.D. Me Gaughey and Feb 7, 1980 from O. Keckemet to Agchem File, 1981
received Jan 23, 1981 under 4581-282; prepared by Union Carbide Corp., submitted by
Pennwalt Corp., Philadelphia, Pa.; CDL:244122-N)
Vilkas, A.G.; Seminara, J. (1980) The Acute Toxicity of Hydout, 22.6% Active
Ingredient, to the Common Mummichog Fundulus heteroclitus (Linnaeus): UCES Project __ ^
74226 No. 11506-41-21. (Unpublished study, including letter dated Feb 7, 1980 from O. ~~
Keckemet to Agchem File, received Jan 23, 1981 under 4581-282; prepared by Union
Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-Q)
U.S. Department of the Interior, Bureau of Reclamation (1964) Results of Algaecidal ^ T
74229 Evaluation Tests of Selected Compounds: Report No. WC-21. (Unpublished study; , „„,
CDL:244122-U)
Latven, A.R. (1975) Letter sent to Obren Keckemet dated Nov 18, 1975 Toxicology
reports on seven products. (Unpublished study received Jan 5, 1978 under 4581-174; 05-Jan-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 1978
Pa.; CDL:232580-B)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Accelerate (N.B.
78182 58-196-3). (Unpublished study received Jan 5, 1978 under 4581-174; prepared by 05-Jan-
Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 1978
232580-D)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B.
58-188-3 (Isopropyl-butanol Formulation). (Unpublished study received Jan 5, 1978 05-Jan-
under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 1978
Philadelphia, Pa.; CDL:232580-K)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B.
58-191-2 (Water Only Formulation). (Unpublished study received Jan 5, 1978 under 05-Jan-
4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 1978
Philadelphia, Pa.; CDL:232580-L)
Latven, A.R. (1975) Toxicology Report for Pennwalt, Agchem Division: Ripenthol N.B.
58-191-2 (23.4%). (Unpublished study, including letter dated Aug 14, 1975 from A.R.
78190 Latven to Obren Kechemet, received Jan 5, 1978 under 4581-174; prepared by
Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL:232580-M)
Latven, A.R. (1976) Letter sent to Obren Keckemet dated Jan 29, 1976 Toxicological
study reports on endothall products. (Un- published study received Jan 5, 1978 under 05-Jan-
4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., 1978
Philadelphia, Pa.; CDL:232580-N)
Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Endothall 05-Jan-
Products, Dermal Toxicity after Limited Expo- sure. (Unpublished study received Jan 5, 1978
136
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1978 under 4581-174; prepared by Pharmacology Research, Inc., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:232580-O)
Latven, A.R. (1976) Toxicology Report For Pennwalt, Agchem Division: Hydout N.B.
77-23-6 (10.3% Endothall). (Unpublished study received Jan 5, 1978 under 4581 -174; 05-Jan-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 1978
Pa.; CDL:232580-Q)
Latven, A.R. (1976) Toxicology Report for Pennwalt, Agchem Division: Accelerate N.B.
77-23-5 (5.5% Endothall). (Unpublished study received Jan 5, 1978 under 4581-174; 05-Jan-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Philadelphia, 1978
Pa.; CDL:232580-S)
Latven, A.R. (1971) Toxicology Report for Pennwalt Corporation: Ac- celerate. „- ^
78199 (Unpublished study received Jan 5, 1978 under 4581- 174; prepared by Pharmacology , „_„
Research, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-W)
Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191
Liquid (N.B. 77 -100-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5662. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-X)
Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5661. Q5 J&n
78201 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AA)
Wise, M.T. (1977) Acute Inhalation Toxicity of Aquathol K (N.B. 77-100-4); Hydrothol
191 Liquid (N.B. 77-100-2); Hydrothol 47 Liquid (N.B. 77-100-3); Aquathol (N.B. 77-
99-7); Des-i-cate Accelerate (N.B. 77-99-6); Knox- out 2 FM (N.B. 4414-94): Laboratory 05-Jan-
Nos. 7E-5660; 7E-5665; 7F-5670; 7E-5675; 7E-5680; 7E-5685. (Unpublished study 1978
received Jan 5, 1978 under 4581 -174; prepared by Cannon Laboratories, Inc., submitted
by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AB)
St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of
Hydrothol 191 Granular (N.B. 77-99-2) on Abraded and Non-abraded Skin of New
78217 Zealand Albino Rabbits: Laboratory No. 7E-5694. (Unpublished study received Jan 5, "
1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:232580-AS)
Becker, J.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Granular (N.B. 77-
78718 99-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5693. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AT)
Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydrothol 191
Granular (N.B. 77-99-2) on New Zealand Albino Rabbits: Laboratory No. 7E-5692. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-AU)
Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5691.
78220 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-AV)
St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Hydout (N.B. 77-99-5) on the
Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5703. (Unpublished 05-Jan-
study received Jan 5, 1978 under 4581-174; prepared by Cannon Laboratories, Inc., 1978
submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-BA)
78604 St. Pierre, F.; Parke, G S.E. (1977) Report: A Primary Dermal Irritation Study of Hydout 05-Jan-
137
-------
(N.B. 77-99-5) on Abraded and Non-abraded Skin of New Zealand Albino Rabbits: 1978
Laboratory No. 7E- 5704. (Unpublished study received Jan 5, 1978 under 4581-174;
prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.;
CDL:232580-BB)
Becker, I; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Hydout (N.B. 77-99-
78605 ^ on New Zealand Albino Rabbits: Laboratory No. 7E-5702. (Unpublished study 05-Jan-
received Jan 5, 1978 under 4581 -174; prepared by Cannon Laboratories, Inc., submitted 1978
by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BC)
Terrell, Y.; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Lab- oratory No. 7E-5701.
78606 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BD)
St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Des-i-cate /Accelerate (N.B.
77-99-6) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5678. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BE)
Becker, J.; Parke, G.S.E. (1977) Report: The Acute Dermal LD50 of Des-i-cate
/Accelerate (N.B. 77-99-6) on New Zealand Albino Rabbits: Laboratory No. 7E-5677. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL: 232580-BF)
Terrell, Y; Parke, G.S.E. (1977) Report on Oral LD50 in Rats: Laboratory No. 7E-5676. Q5 J&n
78609 (Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon , „_„
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BG)
Zeigler, R.L. (1977) Acute Inhalation Toxicity of 1. Aquathol Granular (N.B. 77-99-4); 2.
Hydrothol 191 Granular (N.B. 77-99-2); 3. Hydrothol 47 Granular (N.B. 77-99-3); 4.
78610 Hydout (N.B. 77-99-5): Laboratory Nos. 7E-5690; 7E- 5695; 7E-5700; 7E-5705. 1978"
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-BH)
St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of Des-i-
cate /Accelerate (N.B. 77-99-6) on Abraded and Non-abraded Skin of New Zealand
78614 Albino Rabbits: Laboratory No. 7E-5679. (Unpublished study received Jan 5, 1978 under , „_„
4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt Corp.,
Philadelphia, Pa.; CDL:232580-BM)
Pennsalt Chemicals Corporation (1966) Summary of Justification: Disodium Endothall.
80436 Summary of studies 090585-B through 090585-F. (Unpublished study received on
unknown date under 6G0503; CDL:090585-A)
Pennsalt Chemicals Corporation (1966) Endothall Residue—Cotton. (Compilation;
unpublished study received on unknown date under 6G0503; CDL:090585-C)
Carlson, R.E. (1966) Letter sent to J.D. Watson dated Feb 11, 1966: Analysis of mixtures
80440 of amine endothall with Def and Folex. (Unpublished study received on unknown date
under 6G0503; submitted by Pennsalt Chemicals Corp., Tacoma, Wash.; CDL:090585-F)
Pennwalt Corporation (1979) Fish and Wildlife Safety: Summary. (Unpublished study 25-Mar-
received Mar 25, 1981 under 4581 -223; CDL: 244664-A) 1981
25-Mar-
Pennwalt Corporation (1981) Environmental Chemistry: Summary. Summary of study 1981
244662-B. (Unpublished study received Mar 25, 1981 under 4581-223; CDL:244662-A) 14-Sep-
1981
83034 Pennwalt Corporation (1979) Drift of Endothall Sprays and Their Phytotoxic Effects on 25-Mar-
138
-------
Non-target Plant Species: Project No. WT- 8-78. (Unpublished study received Mar 25, 1981
1981 under 4581 -223; CDL:244662-B)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Rainbow
Trout, Salmo gairdneri Richardson: UCES Project No. 11506-41-17. (Unpublished study,
84147 including letters dated Jan 18, 1980 from A.G. Vilkas to B.D. McGaughey and Feb 7,
1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581-282; prepared
by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-D)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydrothol 191 to the Bluegill
84148 Sunfish, Lepomis macrochirus Rafinesque: UCES Project No. 11506-41-18. (Unpublished 23-Jan-
study received Jan 23, 1981 under 4581 -282; prepared by Union Carbide Corp., submitted 1981
by Pennwalt Corp., Philadelphia, Pa.; CDL:244122-G)
Vilkas, A.G.; Seminara, J. (1979) The Acute Toxicity of Hydout Aquatic Weed Killer
Code AHE 09H901, N.B. No. 84- 1 12-1 to the Bluegill Sunfish Lepomis macrochirus
Rafinesque: UCES Project No. 1 1506-41-19. (Unpublished study, including letter dated 23-Jan-
Feb 7, 1980 from O. Keckemet to Agchem File, received Jan 23, 1981 under 4581 -282; 1981
prepared by Union Carbide Corp., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:
CDL:244122-H)
Seaman, D.E.; Berkenkotter, P.; Chen, T.M.; et al. (1966) Persistence of Residues and
Fates of Herbicides in Rice Fields and in Rice -field Effluents: Progress report. WRC
84382 Project No. W 3 02 67. for the period Mar 1, 1965 to Jan 31, 1966. (Unpublished study 14 ot
received Oct 8, 1981 under 476-2107; prepared by Univ. of California--Davis, Dept. of
Botany, submitted by Stauffer Chemical Co., Richmond, Calif.; CDL:24601 1-M)
St. Pierre, F.; Parke, G.S.E. (1977) Report: The Effects of Hydrothol 191 Liquid (N.B. 77-
84474 100-2) on the Eye Mucosa of New Zealand Albino Rabbits: Laboratory No. 7E-5663. 05-Jan-
(Unpublished study received Jan 5, 1978 under 4581-174; prepared by Cannon 1978
Laboratories, Inc., submitted by Pennwalt Corp., Philadelphia, Pa.; CDL:232580-Y)
St. Pierre, F.; Parke, G.S.E. (1977) Report: A Primary Dermal Irritation Study of
Hydrothol 191 Liquid (N.B. 77-100-2) on Abraded and Non-abraded Skin of New
84475 Zealand Albino Rabbits: Laboratory No. 7E-5664. (Unpublished study received Jan 5,
1978 under 4581-174; prepared by Cannon Laboratories, Inc., submitted by Pennwalt
Corp., Philadelphia, Pa.; CDL:232580-Z)
Pennwalt Corporation (1981) Acute Studies: Endothall. Summary of studies 246012-J , , „
84604 through 246012-P. (Unpublished study received Sep 14, 1981 under 4581-349; ~ ,?p~
CDL : 24601 2 -B)
Inglis, A.; Davis, E.L. (1972) Effects of Water Hardness on the Toxicity of Several
„... , Organic and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Service, Fish- 08-Dec-
Pesticide Research Laboratory. Washington, D.C.: USFWS. (Technical papers of the 1977
Bureau of Sport Fisheries and Wildlife 67; published study; CDL: 232666-L)
Eibert, J., Jr. (1967) Acute Dermal Toxicity (LDI50) in Rabbits: S.A. No. 127387. 17 '
96292 (Unpublished study received Feb 17, 1967 under 7F0570; prepared by Scientific
Associates, Inc., submitted by Pennsalt Chemicals Corp., Bryan, Tex.; CDL:090719-C)
Eibert, J., Jr. (1967) Dermal Irritation in Rabbits: S.A. No. 127388. (Unpublished study
96293 received Feb 17, 1967 under 7F0570; prepared by Scientific Associates, Inc., submitted
by Pennsalt Chemicals Corp. , Bryan, Tex. ; CDL :0907 1 9 -D) 1983° "
Walker, C.R. (1963) Letter sent to Harold L. Lindaberry dated Nov 8, 1963 Fish toxicity 23-Mar-
studies. (U.S. Fish and Wildlife Serv- ice, Fish Control Laboratory; unpublished study; 1967
139
-------
CDL:090719-G)
Cope, O.B. (1966) Letter sent to Edward J. Bowles dated Sep 1, 1966 Fish toxicity of
Des-i-cate (Accelerate). (U.S. Fish and Wildlife 5
Laboratory; unpublished study; CDL:090719-H)
96296 Des-i-cate (Accelerate). (U.S. Fish and Wildlife Service, Fish-Pesticide Research , „,_
Pennsalt Chemicals Corporation (1967) Toxicity to Fish: Accelerate, Accelerate + Folex, .
96297 and Accelerate + Sodium Chlorate. (Unpublished study received Feb 17, 1967 under , „,_
7F0570; CDL:090719-I)
Pennsalt Chemicals Corporation (1967) The Results of Tests on the Amount of Residue 17 F b
96301 Remaining, Including a Description of the Analytical Method Used: Accelerate. , „,_
(Compilation; unpublished study received Feb 17, 1967 under 7F0570; CDL:090719-N)
Pennsalt Chemicals Corporation (1967) Efficacy of Accelerate to Cotton. (Compilation; 17-Feb-
unpublished study received Feb 17, 1967 under 7F0570; CDL:090719-S) 1967
Pennwalt Corp. (1963) Chemical Studies of Endothall Technical, Accelerate and Des-i- ^n O t
101732 cate. (Compilation; unpublished study received Oct 30, 1963 under 4581-284; , „,,
CDL: 007455-A)
Pennwalt Corp. (1966) Efficacy of Accelerate, Des-i-cate and Other Compounds for
101733 Defoliation of Cotton. (Compilation; unpublished study received on unknown date under
4581-284; CDL:007455-B)
Pennwalt Corp. (1954) Full Reports of Investigations Made with Respect to the Safety of -in O t
101734 the Product: Disodium Endothall. (Un-published study received Oct 30, 1963 under , „,_
4581-284; CDL: 007455-C)
Eibert, J. (1966) Summary of Safety Evaluation and Other Animal Studies on Disodium
Endothall. (Unpublished study received on unknown date under 4581-284; prepared by
Scientific Associates, Inc., submitted by Pennwalt Corp., Philadelphia, PA; CDL: 007455-
D)
Inglis, A.; Davis, E. (1968) The Effect of Water Hardness on the Toxicity to Fish of
Several Organic and Inorganic Herbicides. (Unpublished paper presented at the 8th i» T 1
102626 meeting of the Weed Society of America, Feb 5-8, 1968, New Orleans, LA; unpublished
study received Jul 18, 1972 under 2E1221; submitted by U.S. Dept. of the Army,
Washington, DC; CDL:091051-R)
Agchem (1966) Description of Analytical Methods and Results of Analyses for 14 F h
113927 Dimethylcocoamine Endothall (Accelerate) in Cottonseed. (Compilation; unpublished , „,,
study received Feb 14, 1966 under 4581-284; CDL:007456-A)
Agchem (1970) A Special Study on Residues of Endothall on Lint and Seed from Cotton , <- ~
113931 Treated with Accelerate. (Unpublished study received Dec 15,1970 under OF0972; , „_„
CDL: 091670-D)
Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Endothall. 01-Dec-
(Compilation; unpublished study received Dec 1, 1970 under 1F1105; CDL:094507-A) 1970
28-Apr-
1972
Pennwalt Corp. (1972) The Results of Tests on the Amount of Residue Remaining, „. ,,
113953 Including a Description of the Analytical Method Used: Endothall. (Compilation;
unpublished study received May 13, 1972 under 1F1105; CDL:094506-H) 13 M
1972
Pennwalt Corp. (1971) A Report of Two Studies on Residues in Potatoes and Soil after
Treatment with Endothall and 14C Endothall Formulated as DBS -I-CATE. (Compilation;
140
-------
unpublished study received on unknown date under 1F1057; CDL:093370-A)
29-Nov-
Latven, A. (1971) Accelerate: Summary--Acute Dermal Toxicity in Rabbits: Nontoxic at 1971
250MG/KG. (Unpublished study received Nov 29, 1971 under IF 1057; prepared by 09-Jul-
Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, WA; CDL:093370- 1975
C) 20-Dec-
1983
Latven, A. (1971) Accelerate: Summary--Eye Irritancy in Rabbits: Corneal Opacification,
Iridal Congestion, Conjunctival Inflammation and Chemosis. (Unpublished study received 29-Nov-
Nov 29, 1971 under 1F1057; prepared by Pharmacology Research, Inc., submitted by 1971
Pennwalt Corp., Tacoma, WA; CDL:093370-D)
Pennwalt Corp. (1971) Name, Chemical Identity and Composition of Pesticide Chemical: ,„ ^
113957 Endothall. (Compilation; unpublished study received Jan 20, 1971 under 1F1057; , „_,
CDL:093370-E)
Pennwalt Corp. (1971) The Amount, Frequency, and Time of Application of the Pesticide ,„ -,
113958 Chemical: Endothall. (Compilation; un- published study received Jan 20, 1971 under , „_,
1F1057; CDL: 093370-F)
Pennwalt Corp. (1974) The Results of Tests on the Amount of Residue Remaining, „, ,.,
113966 Including a Description of the Analytical Method Used: Endothall. (Compilation; , „_ /
unpublished study received May 1, 1974 under 4G1510; CDL:094009-A)
Pennwalt Corp. (1975) The Results of Tests on the Amount of Residue Remaining, 01 F b
113967 Including a Description of the Analytical Methods Used: Endothall. (Compilation; , „_-
unpublished study received Feb 1, 1975 under 3F1416; CDL:093784-A)
Pennwalt Corp. (1974) The Name, Chemical Identity, and Composition of the Pesticide „, ,.,
113968 Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under , „_ /
4G1510; CDL:094010-A)
Pennwalt Corp. (1974) The Amount, Frequency, and Time of Application of the Pesticide „, M
113969 Chemical: Endothall. (Compilation; unpublished study received May 1, 1974 under , „_ 7
4G1510; CDL: 094010-B)
Pennwalt Corp. (1970) Full Reports of Investigations Made with Respect to the Safety of „,, ,.,
113971 the Product: Endothall. (Compilation; unpublished study received on unknown date under , „_,
1F1105;CDL:094509-A)
Latven, A. (1971) Accelerate: Summary--Acute Oral Toxicity in Starved Rats: LD50 =
650 MG/KG (0.57 ML/KG). (Unpublished study received Nov 29, 1971 under 4581-284; 29-Nov-
prepared by Pharmacology Research, Inc., submitted by Agchem Div., Pennwalt Corp., 1971
Philadelphia, PA; CDL:100915-A)
Walker, C. (1961) The Toxicology, Residue, Degradation, and Effectiveness of Disodium 08-Jul-
Endothal and the Dimethyleocoamine Derivative as Aquatic Herbicides in Fisheries 1965
Habitat. (Unpublished study received Jul 8, 1965 under 4581 -232; submitted by Agchem 15-Mar-
Div., Pennwalt Corp., Philadelphia, PA; CDL: 121844-S) 1966
Agchem (1970) The Results of Tests on the Amount of Residue Remaining Including a ~_ -,
113987 Description of the Analytical Method Used: Endothall. (Compilation; unpublis hed study , „_,
received Jun 27, 1971 under unknown admin, no.; CDL: 124882-A)
Pennwalt Corp. (1975) Name, Chemical Identity, Physical and Chemical Properties, and „„ ^ ,
114487 Complete Composition of the Product: Endothall. (Compilation; unpublished study , „_-
received Jul 9, 1975 under 1F1105; CDL:094700-A)
141
-------
Pennwalt Corp. (1975) Full Reports and Data of Investigations Made on the Safety of the „„ ^ ,
114488 Product to Humans and Domestic Animals: Endothall. (Compilation; unpublished study , „__
received Jul 9, 1975 under 1F1105; CDL:094702-A)
Latven, A. (1971) Accelerate: Summary--Acute Oral Toxicity in Starved Rats: LD50 =
650 Mg/Kg (0.57 Ml/Kg). (Unpublished study received Jul 9, 1975 under 1F1105; 09-Jul-
prepared by Pharmacology Research, Inc., submitted by Pennwalt Corp., Tacoma, WA; 1975
CDL: 094702-D)
Pennwalt Corp. (1972) Responses of Plankton and Macrofauna Communities To Test „„ -, ,
114492 Application of Chemical Herbicides. (Unpublished study received Jul 9, 1975 under , „__
1F1105;CDL:094702-H)
Pennwalt Corp. (1962) Chemical and Physical Properties: Endothall. (Compilation; 09-Jul-
unpublished study received Jul 9, 1975 under 1F1105; CDL:094706-A) 1975
Pennwalt Corp. (1975) Toxicity: Endothall. (Compilation; unpublished study received Jul 09-Jul-
9, 1975 under 1F1105; CDL:094706-B) 1975
Pennwalt Corp. (1974) Residues: Endothall. (Unpublished study received Jul 9, 1975 09-Jul-
underlF1105;CDL:094706-C) 1975
Pennwalt Corp. (1975) Duration of Biological Activity: Endothall. (Unpublished study 09-Jul-
received Jul 9, 1975 under 1F1105; CDL: 094706-F) 1975
Cope, O. (1965) Letter sent to E. Bowles dated Jul 23, 1965 Toxicity study of several , <- M
114511 Pennwalt herbicides against rainbow trout. (U.S. Fish and Wildlife Service, Fish-Pesticide , „,,
Research Laboratory; unpublished study; CDL:007441 -K)
U.S. Fish and Wildlife Service, Fish Control Laboratory (19) Toxicity Study of Selected , , -.,
114513 Test Chemicals on Rainbow Trout, Goldfish, Black Bullhead, and Bluegill. (Unpublished , „,,
study; CDL:007441-M)
Walker, C. (1963) Letter sent to H. Lindaberry dated Apr 24, 1963 Toxicity study of , <- M
114514 selected pesticides on test animals. (U.S. Fish and Wildlife Service, Fish Control , „,,
Laboratory; unpublished study; CDL:007441 -N)
Howell, J. (1963) Letter sent to H. Lindaberry dated Jan 23, 1963 Toxicity of specific
Pennsalt chemicals to the sea lamprey and rainbow trout. (U.S. Fish and Wildlife Service, 15-Mar-
Bureau of Commercial Fisheries, Hammond Bay Biological Station; unpublished study; 1966
CDL: 007441-0)
Zarbock, W. (1961) Letter sent to H. Lindaberry dated Oct 25, 1961 Toxicity test results , - ,,
114516 for TD 191 on bluegills. (Ohio, Dept. of Natural Resources, Div. of Wildlife; unpublished , „,,
study; CDL: 007441-P)
Bowles, E.; Keckemet, J.; Boyle, W.; et al. (1965) Hydrothol 191 as an Aquatic Herbicide , <-
114517 in Flowing Water. (Unpublished study re- ceived Mar 15, 1966 under 4581 -139; ~
submitted by Agchem Div., Pennwalt Corp., Philadelphia, PA; CDL:007441-Q)
Agchem (1975) Chemistry Data on Endothall. (Compilation; unpublished study received 01 -Feb-
Feb 1, 1975 under 458l-EX-21; CDL: 094726-A) 1975
Agchem (1972) Efficacy of Endothall on Various Crops. (Compilation; unpublished study 04-May-
receivedMay 4, 1972 under 4581-284; CDL:095336-B) 1972
Pennwalt Corp. (1973) The Name, Chemical Identity, and Composition of the Pesticide __ ^
114535 Chemical: Endothall. (Compilation; unpublished study received Jun 27, 1973 under , „__
3F1416; CDL:095419-B)
114536 Keckemet, O. (1973) The Amount, Frequency, and Time of Application of the Pesticide 27-Jun-
142
-------
Chemical: Endothall. (Unpublished study received Jun 27, 1973 under 3F1416; submitted 1973
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Pennwalt Corp. (1970) Name, Chemical Identity and Composition of Accelerate Cotton , -
114539 Harvest Aid. (Compilation; unpublished study received Apr 15, 1970 under OF0972;
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Watson, J. (1970) Full Reports of Investigations Made with Respect to the Safety of the , -
114540 Pesticide Chemical, Accelerate Cotton Harvest Aid. (Unpublished study received Apr 15,
1970 under OF0972; submitted by Pennwalt Corp., Tacoma, WA; CDL:095421-F)
Agchem (1977) Residues of Endothal in Soil. (Compilation; un- published study received 26-Oct-
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Agchem (1975) Residues of Endothall in Water. (Compilation; unpublished study 26-Oct-
received Oct 26, 1978 under 4581-282; CDL: 235432-D) 1978
Inglis, A.; Davis, E. (1972) Effects of Water Hardness on the Toxicity of Several Organic
and Inorganic Herbicides to Fish. By U.S. Fish and Wildlife Service, Fish-Pesticide 21-Oct-
Research Laboratory. Washington, DC: USFWS. (Technical papers of the Bureau of Sport 1982
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Pennsalt Chemicals Corp. (1967) Efficacy of Endothall and Other Chemicals on Potatoes. 16-Jun-
(Compilation; unpublished study received Jun 16, 1967 under 7G0608; CDL:090782-C) 1967
Pennwalt (1970) Endothal: Residues in Various Crops. (Compilation; unpublished study
received on unknown date under IF 1105; CDL:090872-A)
3M Co. (1970) Residue Analyses of 3MCAP-D and Other Chemicals in Various Products.
116737 (Compilation; unpublished study received on unknown date under 10556-EX-1;
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Agchem (1967) The Amount, Frequency, and Time of Application of the Pesticide 1 s F b
124667 Chemical: Accelerate Cotton Harvest Aid. (Compilation; unpublished study received Feb , „,_
15, 1967 under 6G0503; CDL: 094600-A)
Agchem (1975) Additional Data in Support of a Petition for Estab- lishment of a „, -,
128664 Temporary Negligible Tolerance for Endothall in or on Rice. (Compilation; unpublished , „„->
study received Jun 1, 1983 under 45811-74; CDL:250413-A)
Becker, J.; Parke, G. (1977) The Acute Dermal LD50 of Des-I-C ate/Accelerate (N.B. 77-
99-6) on New Zealand Albino Rabbits: Laboratory No. 7E-5677. (Unpublished study 20-Dec-
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133024 Laboratory No. 7E-5679. (Unpublished study received Dec 20, 1983 under 4581-206; pre- ~™~
pared by Cannon Laboratories, Inc., submitted by Agchem Div., Pennwalt Corp.,
Philadelphia, PA; CDL:252010-E)
Agchem (1966) Residues: Accelerate. (Compilation; unpublished study received 1966 01-Jan-
under6G0503;CDL:092789-A) 1966
Interregional Research Project No. 4 (1985) The Results of Tests on the Amo unt of -„ .
147209 Endothall Residues Remaining in or on Hops Including a Description of the Analytical , „„£
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Interregional Research Project No. 4 (1984) Endothall on Hops: Efficacy and 30-Apr-
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143
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42359700 (Technical) as Required in the Reregistration DCI: Toxicology Studies. Transmittal of 2 , „„_
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Pedersen, C.; Helsten, B. (1992) Endothall Technical: 21-Day Acute Oral LD50 Study in
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Atochem North America, Inc. (1992) Submission of toxicity data in support of the data 19-Nov-
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Hoffman, G. (1992) An Acute Inhalation Toxicity Study of Hydrothol 191 in the Rat: ,„ „
42560901 Final Report: Lab Project Number: 91-8356. Unpublished study prepared by , „„_
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Elf Atochem N. A., Inc. (1993) Submission of product chemistry data in support of the 21 -Jan-
data call-in for Endothall, Amine Salt. Transmittal of 1 study. 1993
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42629801 Density, pH: Lab Project Number: 4200-92-0334-AS: 4200-92-0334-AS-001. 1993"
Unpublished study prepared by Ricerca, Inc. 43 p.
Elf Atochem N. A., Inc. (1993) Submission of environmental fate data in support of the 18-Feb-
Endothall (Amine Salt) data call-in. Transmittal of 1 study. 1993
Wright, J. (1993) Terrestrial Field Dissipation Studies for Endothall (DBS -I-CATE a
Potato Vine Killer and a Harvest Aid for Alfalfa and Clover) Applied to Potatoes: Lab 18-Feb-
Project Number: WT-1-85: BR-92-54. Unpublished study prepared by Pennwalt Corp. 1993
230 p.
Elf Atochem North America, Inc. (1993) Submission of Prior Efficacy Testing Data in 17
42694500 Support of Experimental Use Permit for TD-2335 (Hydrothol 191). Transmittal of 1 '
Study.
Krieg, D. et al. (1993) Compilation of Prior Efficacy Testing in Support of the
Experimental Use Permit Application for TD-2335: Lab Project No. 2335. Unpublished 17-Feb-
study prepared by Roger Boren, Inc., S-L Agri-Development Corp. and D. Krieg Farm. 64 1993
P-
Elf Atochem North America Inc. (1993) Submission of toxicity data in support of the 14-May-
reregistration DCI for Endothall, Amine Salt. Transmittal of 3 studies. 1993
Mallory, V. (1993) Acute Exposure Oral Toxicity in Rats with Hydrothol 191 (Endothall): ,. M
42774001 Lab Project Number: PH 402-ANA-002-92. Unpublished study prepared by Pharmakon 1993^"
Research International, Inc. 169 p.
Mallory, V. (1993) Acute Exposure Dermal Toxicity with Hydrothol 191 (Endothall): Lab ,.
42774002 Project Number: PH 422-ANA-005-92. Unpublished study prepared by Pharmakon
Research International, Inc. 78 p.
Mallory, V. (1993) Primary Dermal Irritation study with Hydrothol 191 (Endothall): Lab ,. M
42774003 Project Number: PH 420-ANA-002-92. Unpublished study prepared by Pharmakon 1993'
Research International, Inc. 34 p.
Elf Atochem NA, Inc. (1993) Submission of product chemistry data to support the 24-May-
reregistration standard for Endothall. Transmittal of 1 study. 1993
42783201 Wojcieck, B. (1993) Hydrothol 191 (Granular): Color, Physical State, Odor, Bulk 24-May-
144
-------
Density, pH: Lab Project Number: 4200-92-0182-AS. Unpublished study prepared by 1993
Ricerca, Inc. 22 p.
Elf Atochem North America, Inc. (1993) Submission of product chemistry data in support 19-Aug-
of reregistration for endothall. Transmittal of 1 study. 1993
Wojcieck, B. (1993) Accelerate—Color, Physical State, Odor, Specific Gravity, pH, ,„
42889101 Viscosity: Lab Project Number: 4200-92-0174-AS. Unpublished study prepared by ~
Ricerca, Inc. 46 p.
Elf Atochem North America, Inc. (1993) Submittal of Product Chemistry Data in 11 -Jan-
Response to DCI for Reregistration of Endothall Amine Salt. Transmittal of 1 study. 1994
Gallacher, A. (1993) Amine Salt of Endothall Acid--Dissociation Constant: Lab Project 11-Jan-
Number: 4200-92-0323-AS. Unpublished study prepared by Ricerca, Inc. 63 p. 1994
Elf Atochem North America, Inc. (1993) Submittal of Corrosion Characteristics Data in ,, ^
43082000 Support of Reregistration of Endothall Amine Salt (Hydrothol 191 Aqueous, Hydrothol ~~
191 Granular, and Accelerate). Transmittal of 3 studies.
Sweetapple, G. (1993) Hydrothol 191, Aqueous—Corrosbn Characteristics: Lab Project 11-Jan-
43082001 Number. 4200-92-0181 -AS. Unpublished study prepared by Ricerca, Inc. 39 p. 1994
Sweetapple, G. (1993) Hydrothol 191, Granular—Corrosion Characteristics: Lab Project 11-Jan-
Number: 4200-92-0183-AS. Unpublished study prepared by Ricerca, Inc. 35 p. 1994
Sweetapple, G. (1993) Accelerate—Corrosion Characteristics: Lab Project Number: 4200- 11-Jan-
43082003 92_oi75-AS. Unpublished study prepared by Ricerca, Inc. 35 p. 1994
Elf Atochem North America, Inc. (1993) Submission of toxicity data in support of 11-Jan-
reregistration for Endothall Amine Salts. Transmittal of 1 study. 1994
Stankowski, L. (1993) Ames/Salmonella Plate Incorporation Assay on Technical Endothal ,, ^
43154801 Amine Salt Solution: Lab Project Number: PH/301/ANA/001/92. Unpublished study
prepared by Pharmakon Research International, Inc. 110 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothal 15-Mar-
Amine Salt in Support of DCI Reregistration. Transmittal of 1 Study. 1994
SanSebastian, J. (1994) In Vivo Micronucleus Test on Technical Endothal Amine Salt
Solution in Mouse Bone Marrow Erythropoietic Cells: Lab Project Number: PH 309- 15-Mar-
ANA-001 -92. Unpublished study prepared by Pharmakon Research International, Inc. 73 1994
P-
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Hydrothol 191 __ M
43167900 Aquatic Algicide and Herbicide in Support of Reregistration Data Call-in. Transmittal of , „„ ,
2 studies.
Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8-Day ~~
43167901 Acute Dietary LC50 Study in Bobwhite Quail: Lab Project Number: 106-012-01: HWA
153-148. Unpublished study prepared by Bio-Life Associates, Ltd. lOOp.
Pedersen, C.; Thompson, S. (1994) Hydrothol 191 Aquatic Algicide and Herbicide: 8-Day __ M
43167902 Acute Dietary LC50 Study in Mallard Ducklings: Lab Project Number: 106-016-02: 1994""
HWA 153-148. Unpublished study prepared by Bio-Life Associates, Ltd. 96 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall, __ ,,
43169200 Amine Salt (Hydrothol 191) in Support of a Data Call-In Reregistration. Transmittal of 1 , „„ ,
study.
43169201 Armondi, S. (1993) Delayed Contact Hypersensitivity in Guinea Pigs (Buehler) with 23-Mar-
145
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43196900
43196901
43196902
43196903
43210000
43210001
43242300
43242301
43242302
43242303
43265100
43265101
43276500
43276501
Hydrothol 191: Lab Project Number: PH 424-ANA-003-92: ALC-28C2-03. Unpublished
study prepared by Pharmakon Research International, Inc. 106 p.
Elf Atochem North America, Inc. (1994) Submittal of Acute Aquatic Toxicity Data in
Support of Reregistration of Endothall, Amine Salt. Transmittal of 3 studies.
Bettencourt, M. (1994) Hydrothol 191—Acute Toxicity to Rainbow Trout (Oncorhynchus
mykiss) Under Flow-Through Conditions: Final Report: Lab Project Number: 93-8-4891:
12442.0591.6138.108. Unpublished study prepared by Springborn Laboratories, Inc. 75 p.
Putt, A. (1994) Hydrothol 191—Acute Toxicity to Daphnids (Daphnia magna) Under
Flow-Through Conditions: Final Report: Lab Project Number: 93-9-4932:
12442.0591.6139.115. Unpublished study prepared by Springborn Laboratories, Inc. 87 p.
Bettencourt, M. (1994) Hydrothol 191—Acute Toxicity to Sheepshead Minnow
(Cyprinodon variegatus) Under Flow-Through Conditions: Final Report: Lab Project
Number: 93-10-4980: 12442.0591.6140.505. Unpublished study prepared by Springborn
Laboratories, Inc. 70 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for Endothall
Amine Salt in Support of Reregistration Data Call-In. Transmittal of 1 study.
Putt, A. (1994) Hydrothol 191-Acute Toxicity to Mysid Shrimp (Mysidopsis bahia)
Under Flow-Through Conditions: Final Report: Lab Project Number: 93-10-5000:
12442.0591.6141.515. Unpublished study prepared by Springborn Labs., Inc. 72 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data for
ACCELERATE Harvest Aid for Cotton in Support of Re registration DCI. Transmittal of
3 studies.
Mallory, V. (1994) Acute Exposure Oral Toxicity with Accelerate: Lab Project Number:
PH 402-ANA-003-93. Unpublished study prepared by Pharmakon Research International,
Inc. 170 p.
Mallory, V. (1994) Acute Exposure Dermal Toxicity with Accelerate: Lab Project
Number: PH 422-ANA-005-93. Unpublished study prepared by Pharmakon Research
International, Inc. 93 p.
Mallory, V. (1994) Primary Dermal Irritation Study with Accelerate: Lab Project Number:
PH 420-ANA-003-93: DAF-27H3-04. Unpublished study prepared by Pharmakon
Research International, Inc. 39 p.
Elf Atochem North America, Inc. (1994) Submittal of Product Chemistry in Support of
Reregistration of ENDOTHALL. Transmittal of 1 study.
Malone, S. (1994) Amine Salt of Endothall TG (B46-48)-Stability: Lab Project Number:
4200-92-0353-AS-001: 4200-92-0353-AS. Unpublished study prepared by Ricerca, Inc.
57 p.
Elf Atochem North America, Inc. (1994) Submission of toxicology data in support of
reregistration of Endothall Amine Salt. Transmittal of 1 study.
Bettencourt, M. (1994) Hydrothol 191: The Toxicity to Fathead Minnow (Pimephales
promelas) During an Early Life -Stage Exposure: Final Report: Lab Project Number:
94/1/5121: 12442/0692/6151/120. Unpublished study prepared by Springborn
Laboratories, Inc. 84 p.
Elf Atochem North America, Inc. (1994) Submission of exposure assessment data in
support of DCI for reregistration of endothall. Transmittal of 1 study.
43299900
43299901 Lunchick, C. (1994) Assessment of Worker Exposure and Margins of Exposure for
1994
18-Apr-
1994
18-Apr-
1994
18-Apr-
1994
18-Apr-
1994
02-May-
1994
02-May-
1994
24-May-
1994
24-May-
1994
24-May-
1994
24-May-
1994
10-Jun-
1994
10-Jun-
1994
21-Jun-
1994
21-Jun-
1994
12-Jul-
1994
12-Jul-
146
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Endothall Potassium and Amine Salt Formulation: Lab Project Number: EA070594. 1994
Unpublished study prepared by Jellinek, Schwartz & Connolly, Inc. 82 p.
Elf Atochem North America, Inc. (1994) Submission of product chemistry data in support 29-Jul-
ofreregistration for Amine Salt of Endothall. Transmittal of 1 study. 1994
Lorence, P. (1994) Amine Salt of Endothall: Vapor Pressure: Lab Project Number: _„ -, ,
43319601 4200/92/0261/AS: 4200/92/0261/AS/001. Unpublished study prepared by Ricerca, Inc. 70 j^"
P-
Elf Atochem North America, Inc. (1994) Submission of toxicity data in support of 22-Aug-
reregistration for Endothall. Transmittal of 3 studies. 1994
Mallory, V. (1994) Comparative Acute Exposure Dermal Toxicity of Accelerate: Lab __ .
43343501 Project Number: PH/422/ANA/001/94. Unpublished study prepared by Pharmakon 1994~
Research International, Inc. 229 p.
Mallory, V. (1994) Comparative Primary Dermal Irritation Study of Accelerate: Lab 77
43343502 Project Number: PH/420/ANA/001/94. Unpublished study prepared by Pharmakon ~
Research International, Inc. 39 p.
Margitich, D. (1994) 7 Day Repeat Dermal Toxicity Study in Rats Dose-Range-Finding: __
43343503 Amine Salt of Endothall: Lab Project Number: PH/442/ANA/001/93. Unpublished study
prepared by Pharmakon Research International, Inc. 124 p.
Elf Atochem North America, Inc. (1994) Submission of Residue Data in Support of 23-Aug-
Endothall Reregistration. Transmittal of 1 Study. 1994
Sanger, T. (1994)Mono-(N,N-Dimethylalkylamine) Salt of (carbon 14)-Endothall: Nature __
43346601 of the Residue in Cotton: Final Report: Lab Project Number: HWI 6120-168: BR-93-48:
R149301. Unpublished study prepared by Hazleton Wisconsin, Inc. 118 p.
Elf Atochem North America, Inc. (1994) Submittal of Gene Mutation Data in Support of 11 -Jan-
Reregistration of ENDOTHALL, Amine Salt. Transmittal of 1 study. 1994
Stankowski, L. (1993) AS52/XPRT Mammalian Cell Forward Gene Mutation Assay on ,, T
43437801 Technical Endothal Amine Salt Solution: Lab Project Number: PH 314-ANA-001-92.
Unpublished study prepared by Pharmakon Research International, Inc. 144 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity to Aquatic Organisms „_ -,
43437900 Data in Support of the Reregistration of the Amine Salt of Endothall. Transmittal of 1 , „„ ,
Study.
Putt, A. (1994) Hydrothol 191-The Chronic Toxicity to Daphnia magna Under Flow-
43437901 Through Conditions: Final Report: Lab Project Number: 93 -11-5014: ~ ™~
12442.0692.6150.130. Unpublished study prepared by Springborn Labs, Inc. 117 p.
Elf Atochem North America, Inc. (1994) Submission of Product Chemistry Data in 04-Nov-
Support of the Reregistration of Endothall and Salts Group. Transmittal of 2 Studies. 1994
Lorence, P. (1994) Amine Salt of Endothall-Octanol/Water Partition Coefficient: Lab -, N
43441501 Project Number: 4200-92-0260-AS: 4200-92-0260-AS-001. Unpublished study prepared 1994'
by Ricerca, Inc. 53 p.
Wacker Silicones Corp. (1994) Submission of Product Chemistry and Toxicology Data in 02-Sep-
Support of Petition for (Inert Ingredient). Transmittal of 4 Studies. 1994
Etter, S. (1994) (Inert Ingredient): Density Determination. Unpublished study prepared by 02-Sep-
Wacker-Cherme GmbH. 4 p. 1994
43441602 Etter, S. (1994) (Inert Ingredient): Volatility. Unpublished study prepared by Wacker- 02-Sep-
147
-------
Chemie GmbH. lip.
1994
43441603
Etter, S. (1994) (Inert Ingredient): Refractive Index and Residual HC1. Unpublished study
prepared by Wacker-Chemie GmbH. 7 p.
Plotzke, K.; McMahon, J. (1993) Feasibility Study: In vitro Percutaneous Absorption of
43441604 (carbon 14)-(Inert Ingredient) Fluid 350 cst in Male Rat Skin: Lab Project Number: 1993-
10000-38673. Unpublished study prepared by Dow Corning Corp. 13 p.
43465200
43465201
43470100
43470101
43472800
Elf Atochem North America, Inc. (1994) Submission of Toxicology Data in Support of
Endothall Reregistration. Transmittal of 1 Study.
Margitich, D.; Ackerman, L. (1994) 21 Day Dermal Toxicity Study in Rats: Amine Salt of
Endothall: Lab Project Number: PH 430-ANA-001-93. Unpublished study prepared by
Pharmakon Research International, Inc. 323 p.
Elf Atochem North America, Inc. (1994) Submission of Exposure Data in Support of
Endothall Reregistration. Transmittal of 1 Study.
Lunchick, C. (1994) Assessment of Swimmer Exposure to Endothall in Aquathol- and
Hydrothol- Treated Bodies of Water. Unpublished study prepared by Jellinek, Schwartz,
and Connolly, Inc. lip.
Elf Atochem North America, Inc. (1994) Submission of Toxicity and Product Chemistry
Data in Support of the Reregistration of Endothall, Amine Salt. Transmittal of 3 Studies.
Bettencourt, M. (1994) Hydrothol 191-Acute Toxicity to Bluegill Sunfish (Lepomis
43472801 macrochirus) Under Flow-Through Conditions: Final Report: Lab Project Numbers: 94-4-
5253: 12442.0394.6169.105. Unpublished study prepared by Springborn Labs, Inc. 74 p.
43472802
43480800
43480801
43480802
43550200
43550201
43870400
43870401
Lorence, P. (1994) Amine Salt of Endothall-Solubility: Lab Project Numbers: 4200-92-
0259-AS: 4200-92-0259-AS-001. Unpublished study prepared by Ricerca, Inc. 68 p.
Elf Atochem North America, Inc. (1994) Submission of Toxicity Data in Support of
Reregistration of Endothall, Amine Salt. Transmittal of 2 Studies.
Trutter, J. (1994) 13-Week Subchronic Toxicity Study in Rats with Amine Salt of
Endothall: Final Report: Lab Project Number: HWA 153-152. Unpublished study
prepared by Hazleton Washington, Inc. 520 p.
Trutter, J. (1994) 13-Week Subchronic Toxicity Study in Dogs with Amine Salt of
Endothall: Final Report: Lab Project Number: HWA 153-153. Unpublished study
prepared by Hazleton Washington, Inc. 376 p.
Elf Atochem North America, Inc. (1995) Submission of Hazard to Aquatic Organisms
Data in Support of Endothall Reregistration. Transmittal of 1 Study.
Dionne, E. (1995) Hydrothol 191--Acute Neurotoxicity to Eastern Oyster (Crassostrea
virginica) Under Flow-through Conditions: Final Report: Lab Project Number:
12442.0591.6142.504: 93-8-4896. Unpublished study prepared by Springborn Labs, Inc.
108 p.
Elf Atochem North America, Inc. (1995) Submission of Hazard to Non-Target Plants Data
in Support of the Reregistration of Endothall and Salts. Transmittal of 1 Study.
Hoberg, J. (1995) Hydrothol 19 I—Determination of Effects on Seedling Emergence and
Vegetative Vigor of Ten Plant Species: Final Report: Lab Project Number:
12442.0195.6185.610: BR-94-20: 95-8-6045. Unpublished study prepared by Springborn
Labs, Inc. 339 p.
43 873 900 Elf Atochem North America, Inc. (1995) Submission of Product Chemistry Data in
02-Sep-
1994
02-Sep-
1994
22-Aug-
1994
22-Aug-
1994
02-Dec-
1994
02-Dec-
1994
06-Dec-
1994
06-Dec-
1994
06-Dec-
1994
13-Dec-
1994
13-Dec-
1994
13-Dec-
1994
15-Feb-
1995
15-Feb-
1995
11-Dec-
1995
11-Dec-
1995
13-Dec-
148
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Support of the Amended Registrations of Aquathol K Aquatic Herbicide and Hydrothol
191 Aquatic Algicide and Herbicide. Transmittal of 2 Studies.
Lincks, G. (1994) Hydrothol 1914 Aquatic Algicide and Herbicide Manufacturing
43873902 Process: Lab Project Number: QC0007RO.QTR. Unpublished study prepared by Elf
Atochem North America, Inc. 28 p.
43953100
43953101
43954900
43954901
43955000
43955001
44012100
44012101
44037400
44037402
44093400
44093401
44103700
44103701
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall and Salts. Transmittal of 1 Study.
Guyton, B. (1996) Endothall: Magnitude of the Residue in Potato: Lab Project Number:
BR-93-01: U:\ATOCHEM\BR9301FR.DOC. Unpublished study prepared by McKenzie
Laboratories, Inc. 315 p.
Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in
Support of the Registration of Amended Registration of Hydrothol 191 Granular Aquatic
Algicide and Herbicide. Transmittal of 1 Study.
Lincks, G.; Parker, J.; Wright, J. (1994) Hydrothol 191 Granular Aquatic Algicide and
Herbicide: Manufacturing Process: Lab Project Number: QC0012RO.QTR:
QC0003R3.PAM. Unpublished study prepared by Elf Atochem North America, Inc. 23 p.
Elf Atochem North America, Inc. (1996) Submission of Product Chemistry Data in
Support of the Amended Registration of Accelerate: A Harvest Aid for Cotton.
Transmittal of 1 Study.
Lincks, G.; Parker, J.; Wright, J. (1994) Accelerate: A Harvest Aid for Cotton:
Manufacturing Process: Lab Project Number: QC0009RO.QTR: QC0003R3.PAM.
Unpublished study prepared by Elf Atochem North America, Inc. 28 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall and Salts. Transmittal of 1 Study.
Ussary, J. (1996) Endothall: Magnitude of the Residue in Potato Processed Fractions:
Final Report: Lab Project Number: BR-90-09: 52A-90: 52B-90. Unpublished study
prepared by Elf Atochem North America, Inc.; Ussary Scientific Services; and McKenzie
Labs, Inc. 303 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of the
Reregistration of Endothall and Salts. Transmittal of 2 Studies.
Leppert, B. (1996) Endothall: Magnitude of the Residue in Cottonseed with Accelerate
and a Pre-Emergent Use of TD-2335-2: Final Report: Lab Project Number: BR-93-05: 05-
93: 05A-93. Unpublished study prepared by Elf Atochem North America, Inc. 276 p.
{Relates to letter L0000075}.
Elf Atochem North America, Inc. (1996) Submission of Residue and Environmental Fate
Data in Support of the Reregistration of Endothall and its Salts. Transmittal of 3 Studies.
Ussary, J. (1996) Endothall: Magnitude of the Residue in Cottonseed Processed Fractions
from Application of Accelerate, The Harvest Aid for Cotton, and TD2335-2, a Proposed
Boll Opener Use: Final Report: Lab Project Number: BR-94-12: 94-12: 12A-94.
Unpublished study prepared by South Texas Ag Research High Plains, Inc.; Texas A&M
University; and McKenzie Labs. 232 p.
Elf Atochem North America, Inc. (1996) Submission of Residue Data in Support of
Reregistration of Endothall & Salts. Transmittal of 1 Study.
Carr, B. (1996) Residue of Endothall in Alfalfa Seed Following Application of Des-i-cate
and Hydrothol 191 to Alfalfa Seed Crop: Lab Project Number: BR-93-08: 08-93: PRM-
1995
13-Dec-
1995
15-Mar-
1996
15-Mar-
1996
18-Mar-
1996
18-Mar-
1996
18-Mar-
1996
18-Mar-
1996
15-May-
1996
15-May-
1996
18-Jun-
1996
18-Jun-
1996
26-Aug-
1996
26-Aug-
1996
06-Sep-
1996
06-Sep-
1996
149
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44127800
44127801
44127802
44127803
44127804
047. Unpublished study prepared by Elf Atochem North America, Inc. and McKenzie
Laboratories. 219 p.
Elf Atochem North America, Inc. (1996) Submission of Toxicity Data in Support of the
Reregistration of Endothall, Amine Salt. Transmittal of 6 Studies.
Hoberg, J. (1993) Hydrothol 19 I—Determination of Effects on Seed Germination of Ten
Plant Species: Summary Report: Lab Project Number: 93-9-4942: 12442.0593.6159.610:
050892. Unpublished study prepared by Springborn Labs., Inc. 56 p.
Hoberg, J. (1994) Hydrothol 191--Toxicity to the Marine Diatom, Skeletonema costatum:
Summary Report: Lab Project Number: 93-11-5025: 12442.0593.6162.450: 040692.
Unpublished study prepared by Springborn Labs., Inc. 33 p.
Hoberg, J. (1994) Hydrothol 191--Toxicity to the Freshwater Alga, Anabaenaflosaquae:
Summary Report: Lab Project Number: 93-11-5023: 12442.0593.6163.420: 040692.
Unpublished study prepared by Springborn Labs., Inc. 36 p.
Hoberg, J. (1994) Hydrothol 19 l--Toxicity to the Freshwater Alga, Selenastrum
capricornutum: Summary Report: Lab Project Number: 93-11-5022:
12442.0593.6160.430: 040692. Unpublished study prepared by Springborn Labs., Inc. 33
P-
Hoberg, J. (1994) Hydrothol 191--Toxicity to the Freshwater Diatom, Navicula
44127805 pelliculosa: Summary Report: Lab Project Number: 93-11-5021: 12442.0593.6161.440:
040692. Unpublished study prepared by Springborn Labs., Inc. 33 p.
Hoberg, J. (1994) Hydrothol 191--Toxicity to Duckweed, Lemna gibba: Summary Report:
44127806 Lab Project Number: 93-11-5024: 12442. 0593.6164.410: 040692. Unpublished study
prepared by Springborn Labs., Inc. 32 p.
44263500
44263506
44263507
44263508
44320400
44320403
Elf Atochem North America, Inc. (1997) Submission of Metabolism and Residue Data in
Support of the Reregistration of Endothall and Salts. Transmittal of 8 Studies.
Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Celery with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-02: 70-91:
70A-91. Unpublished study prepared by McKenzie Labs, Inc. 237 p.
Toth, J.; Antle, P. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Grapefruit with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Final Report): Lab Project Number: BR-91-04: 74-91: 74A-
91. Unpublished study prepared by McKenzie Labs, Inc. 224 p.
Toth, J.; Amos, L. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Peppers with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: (Draft Final Report): Lab Project Number: BR-91-05: 73-91:
73A-91. Unpublished study prepared by McKenzie Labs, Inc. 223 p.
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of
Petition for Tolerance for Endothall on Apples. Transmittal of 3 Studies.
Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number:
FQPA 697E. Unpublished study prepared by Elf Atochem N.A., Inc. 42 p.
Elf Atochem North America, Inc. (1997) Submission of Residue, Toxicity and Exposure
44322000 Data in Support of the Petition for Tolerance of Endothall on Cotton. Transmittal of 2
Studies.
44322001 Ussary, J. (1997) Endothall: Magnitude of the Residue in Cottonseed and Gin By -
03-Oct-
1996
03-Oct-
1996
03-Oct-
1996
03-Oct-
1996
03-Oct-
1996
03-Oct-
1996
03-Oct-
1996
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
29-Apr-
1997
03-Jul-
1997
03-Jul-
1997
01-Jul-
1997
01-Jul-
150
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44322002
44334300
44334301
44343100
44343101
44578400
44578401
44608600
44608601
44700400
44700401
Products After Application of Accelerate, the Harvest Aid for Cotton, and TD-2335-02, a
Proposed Boll Opener Product: Final Report: Lab Project Number: BR-94-09: 09-94:
09G-94. Unpublished study prepared by Ussary Scientific Services and McKenzie Labs.
415 p.
Piccirillo, V. (1997) FQPA Supplemental Information on Endothall: Lab Project Number:
FQPA 697E. Unpublished study prepared by Elf Atochem North America, Inc. 42 p.
Elf AtochemNA., Inc. (1997) Submission of Residue Data in Support of the
Reregistration of Endothall Acid and Salts. Transmittal of 1 Study.
Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Cabbage with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: Final Report: Lab Project Number: BR-91-01: 71A-91: 71B-
91. Unpublished study prepared by Elf Atochem N.A., Inc. and McKenzie Labs, Inc. 241
P-
Elf Atochem North America, Inc. (1997) Submission of Residue Data in Support of the
Reregistration for Endothall Acid & Salts. Transmittal of 1 Study.
Toth, J.; DeFrancis, J. (1997) Magnitude of the Residue of Endothall on Irrigated Crops:
Treatment of Turnips with Either Aquathol, Aquathol K, Hydrothol 191 Granular, or
Hydrothol 191 Herbicides: Lab Project Number: BR-91-06: 72A-91: 72B-91.
Unpublished study prepared by McKenzie Laboratories, Inc. 237 p.
Elf Atochem North America, Inc. (1998) Submission of Environmental Fate Data in
Support of the Reregistration of Endothall Acid and Salts. Transmittal of 1 Study.
Mao, J. (1997) Endothall Amine Salt--Determination of pH Dependent Hydrolysis: Lab
Project Number: 12442.0396.6209.715: KP-96-01: 96-6-6537. Unpublished study
prepared by Springborn laboratories, Inc. 79 p.
Elf Atochem North America, Inc. (1998) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall Acids and Salts. Transmittal of 1 Study.
Fomenko, J. (1998) Evaluation of Endothall Through the FDA Multiresidue Methods: Lab
Project Number: A036.50: KP-97-18. Unpublished study prepared by Maxim
Technologies, Inc. 63 p. {OPPTS 860.1360}
Elf Atochem North America, Inc. (1998) Submission of Toxicity Data in Support of the
FIFRA 6(a)(2) Requirement for Hydrothol 191. Transmittal of 1 Study.
Serdar, D.; Johnson, A.; Stinson, M. (1995) Seawater Challenge of Chinook Salmon
Smolts (Onchorynchus tshawytscha) Exposed to the Aquatic Herbicide Hydrothol 191:
Lab Project Number: 95-358. Unpublished study prepared by Washington State
Department of Ecology. 30 p.
Elf Atochem North America, Inc. (1999) Submission of Environmental Fate, Risk
44820100 Assessment and Exposure Data in Support of the Reregistration of Endothall Acid and
Salts. Transmittal of 4 Studies.
44820101
44820102
Keckemet, O.; Sharp, J. (1999) Historical Aquatic Residue and Dissipation Data for
Endothall Aquatic Products Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic
Algicide and Herbicide: Lab Project Number: KP-99-02: WT-86-C-11. Unpublished study
prepared by Elf Atochem. 316 p. {OPPTS 860.1400}
Dionne, E.; Sharp, J.; Formella, T. (1999) Dipotassium Salt of Endothall: A Freshwater
Fish and Shellfish Magnitude of Residues Study in a Static Aquatic System: Lab Project
Number: KP-97-14: 52897/171.4/FIFRA: EN1115.95. Unpublished study prepared by Elf
Atochem and ABC Laboratories, Inc. 213 p. {OPPTS 860.1400}
1997
01-Jul-
1997
25-Jul-
1997
25-Jul-
1997
06-Aug-
1997
06-Aug-
1997
11-Jun-
1998
11-Jun-
1998
16-Jul-
1998
16-Jul-
1998
18-Nov-
1998
18-Nov-
1998
05-May-
1999
05-May-
1999
05-May-
1999
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Biever, R. (1998) Hydrothol 191: An Aquatic Dissipation Study for Aquatic Non-Crop
44820103 Uses: Final Report: Lab Project Number: KP-96-14: 98-1-7215: 12442-0896-6214-330.
Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 164 p.
Giddings, J. (1999) Ecological Risk Assessment of Aquatic Herbicides Containing
44820104 Endothall: Final Report: Lab Project Number: KP-98-31: 98-11-7564: 12442-0898-6271-
251. Unpublished study prepared by Elf Atochem and Springborn Laboratories, Inc. 64 p.
Elf Atochem North America (1999) Submission of Environmental Fate Data in Support of
44828800 the Reregistration of Endothall Acid and Salts Containing Products Aquathol K and
Hydrothal 191. Transmittal of 2 Studies.
44828801
44828802
Singh, P.; Ritter, A.; Sharp, J. et al. (1999) Aquatic Dissipation Modeling of Endothall
Acid: Aquathol K Aquatic Herbicide and Hydrothol 191 Aquatic Algicide and Herbicide:
Lab Project Number: ATO KP-97-16: WEI 286.01. Unpublished study prepared by
Waterborne Environmental, Inc. 363 p.
Williams, W.; Ritter, A.; Sharp, J. et al. (1999) An Evaluation of the Aquatic Dissipation
of Endothall Aquatic Product: Aquathol, K Aquatic Herbicide and Hydrothol 191 Aquatic
Algicide and Herbicide: Lab Project Number: ATOKP-98-32: WEI-286.06. Unpublished
study prepared by Waterborne Environmental, Inc. 69 p.
Elf Atochem North America, Inc. (1999) Submission of Toxicity Data in Support of the
44976700 Reregistration of Endothall Acids and Salts Containing Product Hydrothol 191.
Transmittal of 1 Study.
44976701
45039500
45039501
45146300
45146301
45146302
45764300
45764301
92061000
Drottar, K.; Martin, K.; Krueger, H. (1999) Hydrothol 191: A 96-Hour Toxicity Test with
the Marine Diatom (Skeletonema costatum): Final Report: Lab Project Number: 299A-
104. Unpublished study prepared by Wildlife International, Ltd. 38 p. {OPPTS
850.5400}
Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall and Endothall Salts. Transmittal of 1 Study.
Toth, J. (1999) Immunochemical Method for Residues of Endothall in Water: Lab Project
Number: KP-023-00. Unpublished study prepared by Elf Atochem North America, Inc. 74
p. {OPPTS 850.7100}
Elf Atochem North America, Inc. (2000) Submission of Residue Chemistry Data in
Support of the Reregistration of Endothall Acid and its Salts. Transmittal of 2 Studies.
Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potatoes:
Final Report: Lab Project Number: KP-98-22: 22A-98: 22B-98. Unpublished study
prepared by Elf Atochem North America, Inc. 202 p. {OPPTS 860.1500}
Ussary, J. (2000) DES-I-CATE II: Magnitude of the Residue of Endothall on Potato
Processing Fractions: Final Report: Lab Project Number: KP-98-23: 44884: 23A-98.
Unpublished study prepared by Elf Atochem North America, Inc. 162 p. {OPPTS
860.1520}
Cerexagri, Inc. (2002) Submission of Risk and Exposure Assessment Data in Support of
the Registration of Endothall Aquatic Herbicides. Transmittal of 1 Study.
Davis, C.; Ampofo, S. (2002) Exposure and Risk Assessment for Persons Reentering
Non-Food Areas Treated with Endothall Aquatic Herbicides via Irrigation Water.
Unpublished study prepared by Cerexagri, Inc. 26 p.
Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,N-
dimethyl alkyl* amine) endothall (7-ocabicyclo(2. 2.
05-May-
1999
05-May-
1999
05-May-
1999
05-May-
1999
05-May-
1999
20-Oct-
1999
20-Oct-
1999
28-Jan-
2000
28-Jan-
2000
19-Jun-
2000
19-Jun-
2000
19-Jun-
2000
25-Sep-
2002
25-Sep-
2002
25-May-
1990
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Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID __
92061001 00035237. Hydrothol 191-Acute OralLDSO Test-Bobwhite Quail: Project No. 110-115.:
lip.
Shellenberger, T. (1990) Agchem Division-Pennwalt Corp. Phase 3 Summary of MRID __
92061002 00035240. Eight-day Dietary LC50 of Hydrothol 191 to Bobwhite Quail: Project No. 110-
112.: 12p.
Agchem Division-Pennwalt Corp. (1990) Reregistration Phase 3 Response: Mono(N,N- __ ,,
92061999 dimethyl alkyl amine) endothall (7-ocabicyclo(2. 2. Correspondence and Supporting , „„/
Material.
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E. Generic Data Call-In
Note that the complete Data Call-In (DCI), with all pertinent instructions, will be
sent to registrants under separate cover.
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F. Product Specific Data Call-In
Note that the complete Data Call-In (DCI), with all pertinent instructions, will be
sent to registrants under separate cover.
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G. EPA's Batching of Endothall Products for Meeting Acute Toxicity Data
Requirements for Reregistration
In an effort to reduce the time, resources and number of animals needed to fulfill
the acute toxicity data requirements for reregi strati on of products containing Endothall as
the active ingredient, the Agency has batched products which can be considered similar
for purposes of acute toxicity. Factors considered in the sorting process include each
product's active and inert ingredients (identity, percent composition and biological
activity), type of formulation (e.g., emulsifiable concentrate, aerosol, wettable powder,
granular, etc.), and labeling (e.g., signal word, use classification, precautionary labeling,
etc.). Note that the Agency is not describing batched products as "substantially similar"
since some products within a batch may not be considered chemically similar or have
identical use patterns.
Using available information, batching has been accomplished by the process
described in the preceding paragraph. Notwith-standing the batching process, the Agency
reserves the right to require, at any time, acute toxicity data for an individual product
should the need arise.
Registrants of products within a batch may choose to cooperatively generate,
submit or cite a single battery of six acute toxicological studies to represent all the
products within that batch. It is the registrants' option to participate in the process with all
other registrants, only some of the other registrants, or only their own products within a
batch, or to generate all the required acute toxicological studies for each of their own
products. If a registrant chooses to generate the data for a batch, he/she must use one of
the products within the batch as the test material. If a registrant chooses to rely upon
previously submitted acute toxicity data, he/she may do so provided that the data base is
complete and valid by today's standards (see acceptance criteria attached), the
formulation tested is considered by EPA to be similar for acute toxicity, and the
formulation has not been significantly altered since submission and acceptance of the
acute toxicity data. Regardless of whether new data is generated or existing data is
referenced, registrants must clearly identify the test material by EPA Registration
Number. If more than one confidential statement of formula (CSF) exists for a product,
the registrant must indicate the formulation actually tested by identifying the
corresponding CSF.
In deciding how to meet the product specific data requirements, registrants must
follow the directions given in the Data Call-In Notice and its attachments appended to the
RED. The DCI Notice contains two response forms which are to be completed and
submitted to the Agency within 90 days of receipt. The first form, "Data Call-In
Response," asks whether the registrant will meet the data requirements for each product.
The second form, "Requirements Status and Registrant's Response," lists the product
specific data required for each product, including the standard six acute toxicity tests. A
registrant who wishes to participate in a batch must decide whether he/she will provide
the data or depend on someone else to do so. If a registrant supplies the data to support a
batch of products, he/she must select one of the following options: Developing Data
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(Option 1), Submitting an Existing Study (Option 4), Upgrading an Existing Study
(Option 5) or Citing an Existing Study (Option 6). If a registrant depends on another's
data, he/she must choose among: Cost Sharing (Option 2), Offers to Cost Share (Option
3) or Citing an Existing Study (Option 6). If a registrant does not want to participate in a
batch, the choices are Options 1, 4, 5 or 6. However, a registrant should know that
choosing not to participate in a batch does not preclude other registrants in the batch from
citing his/her studies and offering to cost share (Option 3) those studies.
Ten products were found which contain Endothall as the active ingredient. These
products have been placed into two batches and a no batch group in accordance with the
active and inert ingredients and type of formulation.
Batching Instructions:
No Batch: Each product in this Batch should generate their own data. EPA Reg. No.
4581-204 may rely on acute data used to support batch 2.
NOTE: The technical acute toxicity values included in this document are for
informational purposes only. The data supporting these values may or may not meet the
current acceptance criteria.
Batch #
1
2
No Batch
EPA Reg. No.
4581-172
4581-201
1448-352
4581-174
4581-380
4581-381
4581-204
4581-257
4581-284
4581-388
Percent Active Ingredient
11.2
10.1
53.0
53.0
53.0
53.0
40.3
75
15.9
63.0
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H. List of Registrants Sent Data Call-Ins
Technical Registrants Sent Generic Data Call-In:
1. Cerexagri, Inc.
End-Use Registrants Sent Product Data Call-In
1. Cerexagri, Inc.
2. Buckman Laboratory, Inc.
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I. List of Available Related Documents and Electronically Available Forms
Pesticide Registration Forms are available at the following EPA internet site:
http ://www. epa.gov/opprdOO I/forms
Pesticide Registration Forms (these forms are in PDF format and require the
Acrobat reader)
Instructions
2.
3.
Print our and complete the forms. (Note: Form numbers that are bolded
can be filled out on your computer than printed.)
The completed form(s) should be submitted in hardcopy in accord with the
existing policy.
Mail the forms, along with any additional documents necessary to comply
with EPA regulations covering your request, to the address below or the
Document Processing Desk.
DO NOT fax or e-mail any form containing 'Confidential Business
Information' or 'Sensitive Information'.
If you have any problems accessing these forms, please contact Nicole
Williams at (703) 308-5551 or by email atwilliams.nicole@epa.gov
The following Agency Pesticide Registration Forms are currently available via the
internet at the following locations:
8570-1
8570-4
8570-5
8570-17
8570-25
8570-27
8570-28
8570-30
8570-32
8570-34
Application for Pesticide Registration/Amendment
Confidential Statement of Formula
Notice of Supplemental Registration of Distribution of
a Registered Pesticide Product
Application for an Experimental Use Permit
Application for/Notification of State Registration of a
Pesticide To Meet a Special Local Need
Formulator's Exemption Statement
Certification of Compliance with Data Gap Procedures
Pesticide Registration Maintenance Fee Filing
Certification of Attempt to Enter into an Agreement
with other Registrants for Development of Data
Certification with Respect to Citations of Data (in PR
Notice 98-5)
http://www.epa.gov/opprd001/forms/8570-l.pdf
http://www.epa.gov/opprd001/forms/8570-4.pdf
http://www.epa.gov/opprd001/forms/8570-5.pdf
http://www.epa.gov/opprd001/forms/8570-17.pdf
http://www.epa.gov/opprd001/forms/8570-25.pdf
http://www.epa.gov/opprd001/forms/8570-27.pdf
http://www.epa.gov/opprd001/forms/8570-28.pdf
http://www.epa.gov/opprd001/forms/8570-30.pdf
http://www.epa.gov/opprd001/forms/8570-32.pdf
http://www.epa.gov/opppmsdl/PR Notices/pr98-
5.pdf
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8570-35
8570-36
8570-37
Data Matrix (in PR Notice 98-5)
Summary of the Physical/Chemical Properties (in PR
Notice 98-1)
Self- Certification Statement for the Physical/Chemical
Properties (in PR Notice 98- 1)
http://www.epa.gov/opppmsdl/PR Notices/pr98-
5.pdf
http://www.epa.gov/opppmsdl/PR Notices/pr98-
l.pdf
http://www.epa. eov/opppms dl/PR Notices/pr98-
l.pdf
Pesticide Registration Kit: www.epa.gov/pesticides/registrationkit/.
Dear Registrant:
For your convenience, we have assembled an online registration kit that contains
the following pertinent forms and information needed to register a pesticide product with
the U.S. Environmental Protection Agency's Office of Pesticide Programs (OPP):
1. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the
Federal Food, Drug and Cosmetic Act (FFDCA) as Amended by the Food
Quality Protection Act (FQPA) of 1996.
2. Pesticide Registration (PR) Notices
a. 83-3 Label Improvement Program—Storage and Disposal
Statements
b. 84-1 Clarification of Label Improvement Program
c. 86-5 Standard Format for Data Submitted under FIFRA
d. 87-1 Label Improvement Program for Pesticides Applied through
Irrigation Systems (Chemigation)
e. 87-6 Inert Ingredients in Pesticide Products Policy Statement
f 90-1 Inert Ingredients in Pesticide Products; Revised Policy
Statement
g. 95-2 Notifications, Non-notifications, and Minor Formulation
Amendments
h. 98-1 Self Certification of Product Chemistry Data with
Attachments (This document is in PDF format and requires the
Acrobat reader.)
Other PR Notices can be found at http://www.epa.gov/opppmsdl/PR Notices.
3. Pesticide Product Registration Application Forms (These forms are in
PDF format and will require the Acrobat reader.)
a. EPA Form No. 8570-1, Application for Pesticide
Regi strati on/Amendment
b. EPA Form No. 8570-4, Confidential Statement of Formula
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c. EPA Form No. 8570-27, Formulator's Exemption Statement
d. EPA Form No. 8570-34, Certification with Respect to Citations of
Data
e. EPA Form No. 8570-35, Data Matrix
4. General Pesticide Information (Some of these forms are in PDF format
and will require the Acrobat reader.)
a. Registration Division Personnel Contact List
b. Biopesticides and Pollution Prevention Division (BPPD) Contacts
c. Antimicrobials Division Organizational Structure/Contact List
d. 53 F.R. 15952, Pesticide Registration Procedures; Pesticide Data
Requirements (PDF format)
e. 40 CFR Part 156, Labeling Requirements for Pesticides and
Devices (PDF format)
f 40 CFR Part 158, Data Requirements for Registration (PDF
format)
g. 50 F.R. 48833, Disclosure of Reviews of Pesticide Data
(November 27, 1985)
Before submitting your application for registration, you may wish to consult some
additional sources of information. These include:
1. The Office of Pesticide Programs' Web Site
2. The booklet "General Information on Applying for Registration of
Pesticides in the United States", PB92-221811, available through the
National Technical Information Service (NTIS) at the following address:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
The telephone number for NTIS is (703) 605-6000. Please note that EPA is
currently in the process of updating this booklet to reflect the changes in the registration
program resulting from the passage of the FQPA and the reorganization of the Office of
Pesticide Programs. We anticipate that this publication will become available during the
Fall of 1998.
3. The National Pesticide Information Retrieval System (NPIRS) of Purdue
University's Center for Environmental and Regulatory Information
Systems. This service does charge a fee for subscriptions and custom
searches. You can contact NPIRS by telephone at (765) 494-6614 or
through their Web site.
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4. The National Pesticide Telecommunications Network (NPTN) can provide
information on active ingredients, uses, toxicology, and chemistry of
pesticides. You can contact NPTN by telephone at (800) 858-7378 or
through their Web site: ace.orst.edu/info/nptn.
The Agency will return a notice of receipt of an application for registration or
amended registration, experimental use permit, or amendment to a petition if the
applicant or petitioner encloses with his submission a stamped, self-addressed postcard.
The postcard must contain the following entries to be completed by OPP:
Date of receipt
EPA identifying number
Product Manager Assignment
Other identifying information may be included by the applicant to link the
acknowledgment of receipt to the specific application submitted. EPA will stamp the date
of receipt and provide the EPA identifying File Symbol or petition number for the new
submission. The identifying number should be used whenever you contact the Agency
concerning an application for registration, experimental use permit, or tolerance petition.
To assist us in ensuring that all data you have submitted for the chemical are properly
coded and assigned to your company, please include a list of all synonyms, common and
trade names, company experimental codes, and other names which identify the chemical
(including "blind" codes used when a sample was submitted for testing by commercial or
academic facilities). Please provide a CAS number if one has been assigned.
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