United States
    Environmental Protection
    Agency
    Contaminant Candidate List 3
    Chemicals: Screening to a PCCL
Office of Water (4607M)   EPA 815-R-08-003   February 2008 - Draft   www.epa.gov/safewater

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                             Table of Contents
1.0 INTRODUCTION	1
2.0 HEALTH EFFECTS DATA ELEMENTS	2
  2.1 Dose-Response Data Elements	3
  2.2 Categorical Data Elements	4
  2.3 Calibration of the Data for Partitioning into Toxicity Categories	5
    2.3.1 Dose-Response Data	5
    2.3.2 Categorical Data	8
  2.4 Combining the Data Elements for Screening	11
3.0 OCCURRENCE DATA ELEMENTS	11
  3.1 Finished Water Data	12
  3.2 Ambient Water Data	13
  3.3 Environmental Release Data	14
  3.4 Production Data	14
  3.5 Disinfection Byproducts (DBFs) and Drinking Water Treatment Chemicals	15
  3.6 Combining the Data Elements for Screening	15
4.0 CRITERIA FOR SELECTING A PCCL	16
  4.1 Finished and Ambient Water Concentration Data	16
  4.2 Environmental Release Data	17
  4.3 Production Data	18
  4.4 DBFS and Drinking Water Additives	19
5.0 EFFICACY OF THE FRAMEWORK AS A SCREENING TOOL	19
6.0 REFERENCES	20
7.0 APPENDICES	21
  Appendix 1.  Criteria for Selecting the PCCL	21
  Appendix 2.  Chemicals Passing Screening to the PCCL	22
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                               Table of Exhibits
Exhibit 1: Partition for Screening the Universe	2
Exhibit 2: Potency Distributions for the Health Effects Test Set and Universe Chemicals	6
Exhibit 3: Hodge Sterner Scale for Categorizing Chemicals Based on LD50 Values (Health
      Canada 2005)	7
Exhibit 4: Potency Measures for Universe Data Element Partitioned Based on Toxicity
      (mg/kg/day ormg/kg)	8
Exhibit 5: Cancer Grouping and Description under the U.S. EPA 1986 Guidelines	8
Exhibit 6: IARC Cancer Groupings (ITER, 2006)	9
Exhibit 7: Partitioning of Cancer Data Based on TDso Values and Weight of Evidence	10
Exhibit 8: Examples of Potency Data Elements for the Selected Chemical Drawn from the
      Universe	11
Exhibit 9: Number of Chemicals with Median Concentrations Distributed through the screening
      framework by Health Effects Category	13
Exhibit 10: Criteria for Screening Health Effects and Water Categories	17
Exhibit 11: Criteria for Screening Health Effects and Environmental Release Categories	18
Exhibit 12: Criteria for Screening Health Effects and Production Categories	18
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                 List of Acronyms and Abbreviations
 <             Less than
 <             Less than or equal to
 >             Greater than
 >             Greater than or equal to
 |ig/L          Micrograms per liter
 CASRN       Chemical Abstract Services Registry Number
 CCL          Contaminant Candidate List
 CCL 1         EPA's first contaminant candidate list
 CCL 3         EPA's third Contaminant Candidate List
 CE            Clear evidence of carcinogenicity
 CUS/IUR      Chemical Update System/Inventory Update Rule
 DBFs         Disinfection By-Products
 DBF-CAN     Disinfection By-Product with Carcinogenicity Estimates
 DSS-Tox      Distributed Structure-Searchable Toxicity
 DWEL        Drinking water equivalent level
 E             Equivocal
 EE            Equivocal evidence of carcinogenicity
 EPA          United States Environmental Protection Agency
 FDA          United States Food and Drug Administration
 FW/AW       Finished Water/Ambient Water
 H             High probability of causing cancer
 HM           High moderate probability of causing cancer
 IRIS          Integrated Risk Information System (EPA)
 kg            Kilogram
 L             Liter
 L             Low probability of causing cancer
 LD50          Lethal dose 50; an estimate of a single dose that is expected to cause the
               death of 50 percent of the exposed animals; it is derived from experimental
               data.
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Ibs
LM
LOAEL
M
Mar
MCLG
MRDD
mg/kg
mg/kg/day
N
NAWQA
NCFAP
NCI
NDWAC
NE
NOAEL
NPDWR
NREC
NTP
NTPMSR
P
PCCL
PPMP
RfD
QSAR
RfD-eq
SE
                Pounds
                Low moderate probability of causing cancer
                Lowest observed adverse effect level
                Moderate probability of causing cancer
                Marginal probability of causing cancer
                Maximum contaminant level goal
                Maximum recommended daily dose
                Milligrams per kilogram body weight
                Milligrams per kilogram body weight per day
                Negative
                National Water Quality Assessment Program (USGS)
                National Center for Food and Agricultural Policy
                National Cancer Institute
                National Drinking Water Advisory Council
                No evidence of carcinogenicity
                No observed adverse effect level
                National Primary Drinking Water Regulations
                National Reconnaissance of Emerging Contaminants
                National Toxicology Program
                National Toxicology Program multi-species results
                Positive
                Preliminary CCL
                Pesticide Pilot Monitoring Program
                Reference dose
                Quantitative Structure Activity Relationship
                Reference Dose -equivalent
                Some evidence of carcinogenicity
                Tumorigenic dose 50;  The dose-rate which if administered chronically for
                the standard life-span of the species will have a 50% probability of causing
                tumors at some point during that period.
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 TRI            Toxics Release Inventory

 TS             Test Set of chemicals

 U              Universe

 USGS          United States Geological Survey

 yr              Year
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1.0  Introduction
The United States Environmental Protection Agency (EPA) developed a multi-step process,
based on available data, to characterize occurrence and adverse health risks a contaminant may
pose to consumers of public water systems for inclusion on the Contaminant Candidate Lists
(CCLs).  The steps involve:

   1)  Building a broad CCL Universe of potential drinking water contaminants for
       consideration;
   2)  Using straightforward screening criteria related to a contaminant's potential to occur in
       drinking water and potential for public health concern to narrow the Universe to a
       Preliminary CCL (PCCL), and;
   3)  Using a structured classification approach (e.g., a classification model) as a tool, along
       with expert judgment, to develop a proposed CCL from the PCCL.
   4)  Providing opportunities for public comment and contaminant nomination.
This report focuses on the second step, in which the EPA uses an approach to screen chemicals
to a PCCL using the data available from a set of data sources that EPA evaluated for health
effects and occurrence information.

These data sources have yielded approximately 6,000 chemicals with which to populate the CCL
Chemical Universe.  Along with the names and identifying characteristics of these chemicals the
Universe is the repository for the health-related and occurrence-related information. This
information will be used to screen individual contaminants to determine if they should advance
from the Universe to the PCCL. In the case of health effects, the Universe includes both
quantitative and qualitative information on the hazard and/or dose-response properties of the
contaminants.  For occurrence,  the Universe includes both quantitative and qualitative
information on occurrence in water, releases to the environment, and amount produced. The
process for the selection of data sources and Universe chemicals is detailed in the document
entitled, "Contaminant Candidate List 3 Chemicals: Identifying the Universe" (USEPA, 2008a).

EPA based the screening approach, in part, on the National Drinking Water Advisory Council
(NDWAC) recommendation that screening the Universe of chemicals for selection of the PCCL
should be based on widely available data elements that represent important health effects and
occurrence properties (NDWAC, 2004). NDWAC also recommended that the screening be
versatile, yet as simple as possible, and facilitate the identification of those contaminants most in
need of further consideration through the PCCL to CCL process. EPA considered this an
important goal when establishing the screening criteria.

The basic framework developed by EPA for use in screening is shown in Exhibit 1. Applying
this framework to the CCL universe groups contaminants categorized by their toxicity along the
vertical axis and by their occurrence on the horizontal axis. It arrays the data in a way that will
allow for a separation of chemicals into those that move to the PCCL based on their toxicity and
occurrence properties (e.g., upper right in Exhibit 1) and those that are not further evaluated and
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remain in the CCL chemical universe (e.g., lower left in Exhibit 1). The type of available data
determines which chemicals move to the PCCL and those that remain in the universe.
               Exhibit 1:  Partition for Screening the Universe
   Health Effects
                       Occurrence
Low to High Occurrence
   Increasing
   Toxicity
                      Do not pass to PCCL
                                        Pass to the PCCL
To adequately represent health effects data elements, at the screening level, the toxicity
categories must accommodate both dose-response and descriptive data. The occurrence
screening categories must also accommodate a variety of occurrence data elements such as water
concentration, environmental release, or production data.

The challenge in screening is to group the chemicals into categories for health effects and
occurrence using the variety of data elements available in the Universe in a generally equivalent
manner. Section 2.0 describes the approach that was used for grouping the health effects data
elements into the separate toxicity-based categories.  Section 3.0 describes the approach that is
used to group the occurrence data elements.  The application of the screening framework as a
tool, and the results from screening are discussed in Section 4.0. Appendix 1 summarizes the
screening criteria for each type data considered. Appendix 2 shows the contaminants and the
data EPA used that moved them to the PCCL for additional consideration.
2.0  Health Effects Data  Elements
The toxicity information and health effects data extracted from the data sources are quite varied
(USEPA, 2008a and b). The health data elements that provide toxicity information to populate
Exhibit 1 fall into two major categories:

      Data elements that provide dose-response information (potency)
      Categorical data elements on hazard (mostly related to carcinogenic potential).

Some chemicals come from data sources that provide dose-response data in the form of Lowest
Observable Adverse Effects Level (LOAELs), Lethal Dose 50 (LD50), or Reference Doses and
their equivalents (RfDs and RfD-eq).  Some data sources only include descriptive data such as
the positive, negative, or equivocal results from National Toxicology Program (NTP) studies or
International Agency for Research on Cancer (IARC) carcinogen classifications. Still other
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chemicals are in the Universe by virtue of their being on a list, such as the State of California list
of reproductive or developmental toxicants ("Proposition 65") which does not have
accompanying toxicological data. For this reason, it is important that the screening process for
deriving the PCCL be able to accommodate a variety of health effects data inputs.

After examining the breadth of available health effects data, EPA established five categories for
screening. The five categories are as follows:

     Toxicity Category 1
     Toxicity Category 2
     Toxicity Category 3 (the central tendency grouping)
     Toxicity Category 4
     Toxicity Category 5

The toxicity of the grouping decreases as the number for the grouping increases with Toxicity
Category 1 being the most toxic grouping and Toxicity Category 5 the least toxic grouping.
Within each Toxicity Category, the partitioning criteria vary depending on the data element used.
The partitioning criteria that place a LOAEL in Toxicity Category 1  differ from the criteria used
for LD50 values that place it in the same category. Both criteria are intended to identify
contaminants of approximately equivalent toxicity.  The following sections provide information
on the data elements available in the Universe that reflect the dose-response properties and
categorical or descriptive information for the chemicals in the Universe.
2.1 Dose-Response Data Elements
The NDWAC recommended that screening be based on data elements that demonstrate toxic
effects (i.e., LOAELs, LD50s, Cancer Slope Factors, etc.) rather than on data elements that are
based on no effects (i.e., No observed adverse effect level (NOAELs) or that include uncertainty
factors in their derivation (i.e., RfD-eq). However, because of the limitations on the types of
data available for many of the contaminants, it is not possible to be this restrictive.  Of the
chemicals in the universe, about 500 had LOAEL data and about 2,000 had LD50 data. The
remainder were lacking the endpoints recommended by the NDWAC, so EPA used other data
elements that provide quantitative information on dose-response that can be partitioned into the
five toxicity groupings. Major endpoints that fall in this category, in addition to LOAELS and
LD50s, are as follows:

       RfDs and RfD-eq: RfDs, Minimal Risk Levels from the Agency for Toxic Substance and
       Disease Registry, Tolerable Daily Intakes from the World Health Organization (WHO),
       Acceptable Daily Intakes from WHO and the Food and Drug Administration (FDA),
       Public Health Goals from California EPA, and Tolerable Upper Intake Levels from the
       Institute of Medicine.

       NOAELs - No Observed Adverse Effect Levels.

       TD50s - The dose-rate which if administered chronically for the standard life-span of the
       species will have a 50% probability of causing tumors throughout that period. Chemicals
       with TDso data have positive cancer results in at least one study.
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      Maximum Recommended Daily Dose (MRDD) - Recommendations for the maximum
       adult daily therapeutic doses for pharmaceuticals (FDA).

Including the measures of toxic potency listed above in the health effects screening framework
expands the number of chemicals from the Universe that can be screened on the basis of their
dose-response for possible inclusion in the PCCL. The approach used to partition each of these
toxicity measures for screening is described in Section 2.3.
2.2 Categorical Data Elements
There are three groups of categorical data elements and health effects information in the
Universe. These groups categorize chemicals according to their carcinogenic potential,
mutagenicity information, or classification as a developmental or reproductive toxicant.
Categorical data sets in the Universe include the following:

        U.S. EPA Cancer Groupings

        IARC Cancer Groupings

        NTP weight-of-evidence findings from cancer bioassays

        National Cancer Institute (NCI) weight-of-evidence findings from cancer bioassays

        California EPA list of chemicals suspected of causing cancer

        EPA Water Disinfection By-Products with Carcinogenicity Estimates (DBF-CAN)
        groupings based on carcinogenic potential derived from Quantitative Structure Activity
        Relationship (QSAR) projections and expert judgment

        California list of chemicals suspected of being developmental or reproductive toxicants

        U.S. EPA groupings of disinfection by-products (DBFs) based on QSAR predictions of
        their ability to cause developmental or reproductive toxicity.

Even with the expansion of the types of dose-response data suitable for screening described in
Section 2.1, many chemicals in the Universe lack dose-response data elements making it
important to use the categorical information.

The categorical cancer information is amenable to the screening approach illustrated in Exhibit 1
because, in most cases, it includes subcategories related to the strength of the cancer data and its
applicability to humans.

The second group of categorical data elements provides information on genotoxicity and
mutagenicity. This group is considered categorical because results are classified as positive,
negative, or equivocal. However, it is common to have multiple genotoxicity assays for any
given chemical, and it is unusual for all assays of a given chemical to have the same result.
Accordingly, there is a need to integrate all of the genotoxicity results and determine a
categorical weight-of-evidence if the data are to be useful for screening. However, the Universe
contained few weight-of-evidence findings on genotoxicity, and, when such results  are available,
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they are usually tied to cancer assessments with dose-response measures. Accordingly, the use
of the categorical cancer information along with TD50 dose-response data reduces the importance
of including genotoxicity as a screening criterion. The genotoxicity data remain available as a
supplemental health effects element that can be applied in the evaluation of the PCCL and in
making decisions for chemicals that fall close to the screening barrier that separates the
chemicals that will move to the PCCL from those that will remain in the Universe.

The third type of categorical information in the database comes from the State of California's list
of reproductive and developmental toxicants or other similar lists. These lists are groupings that
are  based on a single toxicological property, but not partitioned by the degree of hazard. In this
respect the lists are different from the cancer information that includes subdivisions based on the
hazard weight-of-evidence and  supported by quantitative cancer slope factors and/or TDso
values. For this reason, the California list of developmental and reproductive toxicants and the
California list of carcinogens are not used for the screening framework but they are retained as
supplemental information that may be useful in the evaluation of the initial PCCL screening
results.
2.3 Calibration of the Data for Partitioning into Toxicity Categories

2.3.1  Dose-Response Data
As mentioned in the previous section, the health effects information found in the Universe is
diverse. Accordingly, the challenge in screening is to be able to partition each type of data
element into the five toxicity-based categories in a reproducible and logical manner. The main
data elements proposed for screening (RfD-eq, NOAEL, and LOAEL values) have been used by
EPA in establishing Maximum Contaminant Level Goals (MCLGs) or Lifetime Health
Advisories.  Accordingly, it was possible to compile a set of test chemicals (TS) found in
drinking water that had multiple data elements from the set of toxicity data (i.e., RfD-eq,
NOAEL, LOAEL, LD50) and examine the range and distribution of values associated with each
dose-response data element. Distributions were also determined for the other measures of dose-
response found in the Universe (U) at the time the screening process was developed (i.e.,
LOAELs, LDsoS, MRDDs, TDsos). Each measure of toxicity covered a range of close to ten
orders  of magnitude and had a roughly normal distribution when arrayed according to their logio
value rounded to a single significant figure (Exhibit 2). Each data set is skewed toward higher
potency chemicals due to the difficulty in identifying conventional toxicity data for many
chemicals that are slightly or practically  nontoxic.  The RfDs and NOAELs in the Universe were
not initially compiled.
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     Exhibit 2:  Potency Distributions for the Health Effects Test Set
                            and Universe Chemicals
Log
<-7
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
RfD-eq
TS
1

1
8
59
105
121
63
11
4
O




NOAEL
TS





5
21
45
92
106
29
13



LOAEL
TS




1
2
13
28
63
121
85
28
1


U




O
4
15
52
83
120
139
73
8


MRDD
U



3
4
15
53
183
271
453
223
12



TD50
U




3
8
17
53
184
266
272
139
25
1

LD50
TS






0
0
9
11
45
75
40
1

U






1
1
10
26
239
1023
672
19

TS = Test Set, U= Universe
The TS for RFDs includes chemicals on the IRIS as well as those with MCLGs
and/or Health Advisory values
A reference point for the potency of drinking water was established by converting the 2 L/day,
90 percentile drinking water intake (used by the Office of Water for risk analyses), into a
NOAEL equivalent mg/kg/day dose for 70 Kg adults. This dose equivalent, for perspective,
would occur in the Log 5 cell in the NOAEL health effects diagnostic set. Including this dose-
response value for drinking water allows all other contaminants to be viewed in perspective as
they relate to the CCL screening framework (in Exhibit 2).

EPA evaluated the distribution of the Test Set or the Universe dose-response parameters shown
in Exhibit 2. EPA defined the modal grouping from the distribution for each type of toxicity
parameter as Toxicity Category 3 for screening. The higher and lower screening toxicity
categories were partitioned from the remainder of the distribution based on its shape and the
numeric groupings of chemicals above and  below the modal grouping. For most parameters other
than the LD50 values, partitioning was based on powers of 10 and a desire to be more inclusive
rather than exclusive during the screening process, especially during initial testing.

There is a discrepancy between the modal LOAEL in the Universe and that from the Test Set.
The data from the Universe have a modal value that is one logio unit less toxic than that for the
Test Set (Exhibit 2). A decision was made by EPA to base Toxicity Category 3 LOAEL
grouping on the Test Set rather than the universe because the combination of the Office of Water
Health Advisory chemicals and those on Integrated Risk Information System (IRIS) that made
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up that set is more representative of chemicals that EPA had found to be of environmental and/or
regulatory concern than the Universe compilation.

The partitioning for the LDso values was treated differently from the RfD-eq, NOAEL, and
LOAEL values because there has long been an accepted categorization of LDso values into six
categories, The Hodge Sterner scale is shown in Exhibit 3 (Hodge Sterner, 1956). The six
categories were reduced to the five screening categories by combining the two lowest toxicity
categories from the Hodge Sterner Scale.
       Exhibit 3:  Hodge Sterner Scale for Categorizing Chemicals
                Based on LD50 Values (Health Canada 2005)
Extremely Toxic
Highly Toxic
Moderately Toxic
Slightly Toxic
Practically nontoxic
Relatively harmless
<1 mg/kg
1 - <50 mg/kg
50 - <500 mg/kg
500 - <5000 mg/kg
5000 -< 15000 mg/kg
> 15000 mg/kg
The MRDD values were partitioned as if they were LOAELs because the maximum therapeutic
doses are established by balancing their benefit with their risk. Accordingly, although MRDD
doses are safe for human consumption, some adverse effects are always possible, especially in
sensitive populations. This situation justifies considering them as LOAELs rather than
NOAELs.

The partitioning of the TDso values was unique in that they apply to the probability for tumor
development. They were, accordingly, combined with the categorical data elements that are
discussed in Section 2.3.2.

Exhibit 4 illustrates how the Universe dose-response data elements partition into their toxicity
categories for screening. The partitioning considered both the distribution of the data for each of
the health effects data elements and the number of contaminants that would fall in each of the
toxicity categories. The testing of the partitioning for the third CCL (CCL  3) Universe at the
time of protocol development suggested  that the approach performed reasonably well. Its
performance can be further evaluated and modified if needed for future CCLs.
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  Exhibit 4:  Potency Measures for Universe Data Element Partitioned
                  Based on Toxicity (mg/kg/day or mg/kg)

Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
RfD
O.0001
0.0001 -O.001
0.001 -<0.05
0.05 -<0.1
>0.1
NOAEL
<0.01
0.01 -<1
1 -<10
10 -< 1000
>1000
LOAEL
<0.01
0.01 -<1
1 -<10
10-<1000
>1000
MRDD
<0.01
0.01 -< 1
1 -<10
10 -< 1000
>1000
LD50
<1
1 -<50
50 - <500
500 - 5000
>5000
2.3.2 Categorical Data
As discussed in Section 2.0, the categorical data selected for screening were primarily those that
applied to cancer and provided a weight-of-evidence evaluation for the probability that the agent
was carcinogenic to humans. The data from the EPA include either an alpha-numeric grouping
or a weight-of-evidence statement on carcinogenic potential and often a cancer slope factor. The
alpha-numeric groupings (Exhibit 5) apply to the chemicals evaluated for their carcinogenicity
under the Guidelines for Carcinogen Risk Assessment (USEPA, 1986).
         Exhibit 5:  Cancer Grouping and Description under the
                          U.S. EPA 1986 Guidelines
Group
A
Bi
B2
C
D
E
Description
Human carcinogen
Probable human carcinogen
Limited evidence in animals and inadequate or no evidence
in humans
Possible human carcinogen
Not classifiable as to human carcinogenicity
Evidence of noncarcinogenicity in humans
In 1996 and 1999 the U.S. EPA issued draft updated guidelines for evaluating carcinogenicity.
EPA finalized the revised guidelines in 2005 (USEPA, 2005). Chemicals evaluated under the
2005 Guidelines and its drafts are grouped according to five weight-of-evidence descriptors as
follows:

     Carcinogenic to humans
     Likely to be carcinogenic to humans
     Suggestive evidence for carcinogenicity
     Insufficient evidence to determine carcinogenicity
     Not likely to be carcinogenic

IARC uses a Numeric-Alpha grouping for carcinogens (ITER, 2006) that is similar to the 1986
U.S. EPA groupings.  Exhibit 6 summarizes the IARC cancer groupings. The Health Canada
groupings are derived from the IARC system but use Roman Numerals I through V for the five
IARC groupings (ITER, 2006).
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              Exhibit 6: IARC Cancer Groupings (ITER, 2006)
Group
1
2A
2B
O
4
Description
Carcinogenic to humans
Probably carcinogenic to humans
Possibly carcinogenic to humans
Not classifiable as to its carcinogenicity to humans
Probably not carcinogenic to humans
The data abstracted from the NTP database on cancer studies are those from studies conducted
by both the NTP and the NCI.  The NTP (2005) describes the results of the studies as:

      Clear evidence of carcinogenicity (CE)
      Some evidence of carcinogenicity (SE)
      Equivocal evidence of carcinogenicity (EE)
      No evidence of carcinogenicity (NE).

The NTP studies are conducted using groups of male and female rats and/or mice.  The results in
both species and both sexes have separate weight-of-evidence determinations. "Clear evidence"
in both species and both sexes is stronger evidence that a chemical could be a potential  human
carcinogen than "clear evidence" in only two species-one sex, or in two sexes-one species. Clear
evidence is stronger than some evidence and some evidence stronger than equivocal evidence.
EPA took these distinctions into account when partitioning chemicals based on their NTP
categorical cancer data.

The NCI was responsible for conducting cancer studies for the U.S.  Public Health Service prior
to the formation of the NTP. They used a simpler system (NTP, 2005) by reporting results from
cancer bioassays as either positive (P), negative (N)  or equivocal (E). The NCI findings are
reported in the NTP database. NCI Studies were also conducted in both sexes for rats and mice.
The studies with positive results in both species and  both sexes  are those that present the highest
level of concern regarding the potential for human carcinogenicity.

The DPB-CAN data grouping within the EPA Distributed Structure-Searchable Toxicity (DSS-
Tox) database is a compilation of projections on carcinogenic potential, of an assortment of
unregulated DBFs, derived from QSAR modeling and expert judgment. The chemicals are
categorized according to the estimated probability that they will cause cancer from high (H) to
unlikely (L) with intermediary probabilities of high moderate (HM), moderate (M), low
moderate (LM) and marginal (Mar).

EPA placed the qualitative  and quantitative data for  carcinogenicity  of chemicals only in the
upper three toxicity categories. Carcinogens are not generally considered as having low toxicity.
The cancer screening criteria are based on USEPA, IARC, and NTP cancer groupings for
screening rather than the cancer slope factors because many chemicals are categorized for cancer
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but do not have cancer slope factors. Therefore use of the categorical data is more inclusive than
use of slope-factor data.
An exception to using the categorical data for the screening for the cancer endpoint is the
data. The TDso data set includes quantitative estimates of cancer risk for some chemicals that are
not in the other data sets, and thus they will be used in screening in cases where no categorical
cancer data elements are available.

EPA partitioned the cancer-related data elements in the Universe as described in Exhibit 7.
Quantitative measures of dose-response for carcinogenicity will be used in scoring the Potency
attribute for potential carcinogens in the PCCL to CCL process (see the PCCL to CCL Report,
EPA, 2008b) but not in screening at the Universe level.
           Exhibit 7:  Partitioning of Cancer Data Based on TD50
                        Values and Weight of Evidence

Toxicity
Category 1
Toxicity
Category 2
Toxicity
Category 3
TD50
<0.1
0.1 -
100
>100
EPA
Group A;
Human
Carcinogen
Groups B 1 and
B2; likely
carcinogens
Group C;
Suggestive
evidence of
carcinogenicity
IARC
/HC
Group 1
Group 2A
Group 2B
NTP
CE 2 species/2
sexes; or 2
species; or 2
sexes
Combinations
of CE, SE, EE,
andNE
Combinations
ofSE,EE, and
NE
NCI
P 2 species/2
sexes; or 2
species; or 2
sexes
Combinations
of P, Band N
Combinations
ofEandN
DSS-Tox
H
HM
Mand
LM
* * Cancer data placed chemicals in only the three highest Toxicity Categories
CE = clear evidence, SE = some evidence, EE = equivocal evidence, NE = no evidence
P= positive, N= Negative, E = equivocal
H = high probability, HM= high to medium probability, M = medium probability, LM = medium to
low probability
The U.S. EPA Groups D and E, "Insufficient Evidence" and "Not Likely" descriptors, as well as
the IARC Group 3 and 4 or Health Canada Groups IV or V, are not used when partitioning the
categorical data elements as described in Exhibit 7. The DSS-Tox, "unlikely" and TDso, "NP"
field entries are also not used. EPA's decision is based on the premise that low toxicity concerns
related to low tumorigenic properties do not mean there is no systemic toxicity for a
contaminant.  In these cases, other non-cancer data were used for screening.
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2.4 Combining the Data Elements for Screening
As discussed in this report, there are a variety of data elements available in the Universe that can
be used to screen for adverse health effects.  To avoid favoring chemicals with rich data sets, the
EPA evaluated all available dose-response and categorical data elements for a given chemical in
the  screening process. When each of the data elements for a given chemical is placed in the
screening framework, the most conservative health effects category is identified. Accordingly, if
there is just one data element that places a chemical in Toxicity Category 1 it will be categorized
as such even if some of the other data elements for that same chemical place it a lower toxicity
category. For example, if a chemical is classified as a 2A carcinogen by IARC it will be placed
in Toxicity Category 2 even if its LOAEL from a different study places it in Toxicity Category 3.
Exhibit 8 includes several examples drawn from the Universe of chemicals that have either one
or multiple available potency data elements. The data elements used to evaluate the chemicals
are bolded.
    Exhibit 8:  Examples of Potency Data Elements for the Selected
                     Chemical Drawn from the Universe
Chemical
4-Biphenylamine
Hexane
Methylazoxy-
methanol acetate
Molybdenum oxide
3 -hydroxycarbofuran
Methylenediphenol
BMX-1
Primiphos methyl
Toxicity
Category 1
Group 1







Toxicity
Category 2
TD50



LD50

DBF-CAN
NOAEL
Toxicity
Category 3


Group 2B
NTP

LOAEL

RfD-eq
LOAEL
Toxicity
Category 4

LD50



LD50

LD50
LOAEL
Toxicity
Category 5

RfD-eq






Four of the contaminants in Exhibit 8 have more than one health effects data element.  Each
health effects data element for a chemical will be used for the screening process but the one data
element demonstrating the highest potency in combination with its measure of occurrence will
determine if it is selected for the PCCL. For example, 4-biphenylamine falls in Toxicity
Category 1 because it has an IARC Group 1 classification even though its TD50 places it in
Toxicity Category 2.  Hexane falls in Toxicity Category 4 based on its LDso value even though
its RfD-eq value would place it in Toxicity Category 5.
3.0  Occurrence Data Elements
EPA found that data elements representing a chemical's potential to occur in drinking water vary
greatly in terms of the occurrence factor they represent.  The goal was to determine which data
elements best represented the potential to occur in drinking water.  EPA considered and
evaluated data elements in the following categories:
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      Finished Water - measures concentration and frequency of detections
      Ambient Water - measures concentration and frequency of detections
      Total Releases in the Environment - measures pounds per year and number of states
      Pesticide Application Rates - measures pounds per year and number of states
      Production volume - measures pounds per year

In addition to evaluating quantitative data elements, EPA also analyzed chemicals with
descriptive data based upon their likelihood of occurring in drinking water. Examples of these
types of chemicals include disinfection byproducts and drinking water treatment additives. The
following sections describe the occurrence categories and how EPA utilized them in the
development of the screening criteria.

To analyze the occurrence data and develop the screening criteria, EPA assembled a diagnostic
test set of approximately 200 chemicals. Some of these chemicals were selected from past CCLs
and National Primary Drinking Water Regulations (NPDWRs), and some were randomly pulled
from the Universe of contaminants considered for the draft CCL 3.  Most of them had data on
concentrations in water, environmental release and production, and as such constituted a
relatively complete set of occurrence data elements.
3.1 Finished Water Data
Using the Universe as a starting point, EPA considered data elements that are readily available
for chemicals in finished water. The finished water data elements are from the National
Contaminant Occurrence Database Rounds  1 and 2, the National Inorganic Radionuclides
Survey, the Unregulated Contaminant Monitoring Regulation monitoring, the Information
Collection Rule database for DBFs, U.S. Department of Agriculture Pesticide Data Program
(PDF), and Pesticides Pilot Monitoring Program (PPMP).

The finished water data elements evaluated  include:

       percent of samples with detections,
       percent of public water systems with detections,
       median concentration of detections,
       mean concentration of detections, and
       maximum concentration of detections;

The median, mean, and maximum concentration values are based on analytical detections only.
Non-detections were not included in these concentration measure calculations. In both the data
sets for finished and ambient water (Section 3.2), some chemicals had no detections at any of the
sites surveyed. Some data sets included mean, median, and maximum values whereas others
included  only one or two of the data elements.

For screening purposes, EPA determined that the concentration data were the most appropriate
data elements because they have a more direct relationship with dose-response than the detection
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 frequency. The concentration data ranged from <0.1 |J,g/L to > 10,000 |J,g/L.  The range was
 subdivided using powers often.  Some chemicals had finished water data available from multiple
 sources; in those cases, the highest value was used for the purposes of screening.

 Using the toxicity categories EPA arrayed 107 chemicals with finished water data based on their
 toxicity data elements and their median concentration in finished water as shown in Exhibit 9.
 This Exhibit illustrates the distribution of chemicals across the categories.  EPA developed
 additional analyses that focused on the specific chemicals within the different occurrence
 categories to set the screening criteria.
       Exhibit 9:  Number of Chemicals with Median Concentrations
Distributed through the screening framework by Health Effects Category
Health Effects Categories
Toxicitv Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Total
Occurrence - Finished Water - Median (ug/L)
0-
<0.1
1
0
0
0
0
1
0.1-
<1
7
5
8
4
1
25
1-
<10
22
15
16
6
2
61
10-
<100
0
8
3
0
1
12
100-
<1,000
4
0
0
1
0
5
1K-
<10K
1
0
0
0
0
1
>10K
0
0
1
1
0
2
Totals
35
28
28
12
4
107
 Exhibit 9 shows that about 82% (87 of 107) of the chemicals with finished water data have
 median concentrations less than 10 |ig/L, a concentration that is not of high concern for Toxicity
 Category 3 to Toxicity Category 5 chemicals.  This grouping would have a maximum drinking
 water equivalent level (DWEL) of > 40 jig/1 based on an RfD of 0.001 [see section 4.1 for
 additional information].  However, these same concentrations for finished water are of greater
 concern for chemicals with Toxicity Category 1 and Toxicity Category 2 RfDs.  These types of
 analyses helped EPA evaluate the effectiveness of the screening framework as a tool to separate
 chemicals of high concern from those of low concern, especially for chemicals with finished
 water data.
 3.2 Ambient Water Data
 EPA obtained data on ambient water values from the United States Geological Survey (USGS)
 National Water Quality Assessment Program (NAWQA), the USGS National Reconnaissance of
 Emerging Contaminants (NREC), and the PPMP.  The NAWQA data include all the nationwide
 data from Cycle 1 of NAWQA, which encompasses data collected from 1992 to 2001.  The
 NRECs database includes occurrence data collected by the USGS Toxic Substances Hydrology
 Program from 1999 to 2001 in samples from  142 streams, 55 wells, and seven effluent samples
 from 36 states. The PPMP data includes pesticide concentrations in water, and the sampling
 methods include 178 different pesticides and  degradation products.
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The ambient water data elements analyzed include:

      percent of samples with detections,
      percent of sites with detections,
      median concentration of detections,
      mean concentration of detections, and
      maximum concentration of detections;

As was the case for finished water, the median, mean, and maximum values are based on
analytical detections only.  Non-detections were not included in the concentration datasets. The
subdivisions for the data were developed by first determining the range of available ambient
water concentration data, and then partitioning the range by powers often. In this case, the
concentration data ranged from <0.01 (ig/L (for all concentration data) to >10,000 ng/L.  One of
the data sources, NREC, did not contain mean or maximum concentration data, so it was  only
represented in the percent of samples, percent of sites, and median concentrations. EPA
developed matrices similar to Exhibit 9 for all of the ambient water data elements using the set of
200 diagnostic chemicals.
3.3 Environmental Release Data
The environmental release data are those reported for 2002 from the Toxics Release Inventory
(TRI) and the National Pesticide Use Database, as created by the National Center for Food and
Agricultural Policy (NCFAP). The most recent version of the NCFAP database was released in
2000, and reflects pesticide use in 1997.

The environmental release data elements considered include:

       total releases to the environment (Ibs/yr)
       number of states with total releases
       pesticide application (Ibs/yr)
       number of states with pesticide application.

As was the  case for the finished and ambient water data, EPA chose to use the data on the
pounds per  year released to the environment for screening rather than the number of states with
releases.  The subdivisions used for release data were developed by first determining the range of
release values represented by the data, and then partitioning the range based on powers often. In
this case, the release data ranged from less than 10 pounds per year to  greater than 10 million
pounds per  year.  EPA developed matrices similar to Exhibit 9 for all of the environmental
release data elements.
3.4 Production Data
The data used to assess production volume are the Toxic Substances Control Act chemical
production volume ranges reported under the Chemical Update System/Inventory Update Rule
(CUS/IUR). EPA used the most recent year of data available for each particular chemical.
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Every chemical on EPA's High Production Volume list is also in the CUS/IUR data source.
Therefore, CUS/IUR is the primary source for production data.

CUS/IUR reports chemical production data as ranges rather than as exact values. Therefore,
EPA chose to use those ranges as the subdivisions for the production occurrence data. The
production data ranges from less than 10,000 Ibs/yr to greater than 1 billion Ibs/yr. EPA
developed matrices similar Exhibit 9 for all of the production data on the test set chemicals.
3.5 Disinfection Byproducts (DBFs) and Drinking Water Treatment
Chemicals
EPA recognized that two groupings of chemicals have water occurrence even in cases where
quantitative data were not available: the DBFs from the DSS-Tox data source and the treatment
chemicals from NSF Standard 60. In many cases there were finished water data or production
data for some of these chemicals but, some of the chemicals lacked quantitative data.  Among the
Universe of chemicals that lacked the preferred data elements, both the DBFs and treatment
chemicals have a strong potential to be present in drinking water. Accordingly, EPA is moving
chemicals in these two categories forward to the PCCL for further evaluation, even when limited
health effects or occurrence information are available.
3.6 Combining the Data Elements for Screening
EPA selected the occurrence data elements for screening based upon their presence in the
universe and their suitability as a screening tool.  Analyses were performed to see if the
occurrence could be correlated across the various data elements. The diagnostic chemicals were
used for the correlation analysis since most had data for the following data elements: mean,
median, or maximum concentrations in finished and/or ambient water, amount released to the
environment, and production volume. The analyses with the diagnostic chemicals demonstrated
a limited correlation across the data elements. A chemical with a high release to the environment
did not necessarily occur in finished or ambient water at a high concentration or even have a high
frequency  of detections.  As a result, EPA decided to apply the occurrence screening data
elements in a hierarchical manner.

Chemicals known to occur in finished or ambient water occupy the highest position in the
hierarchy and are most representative of a chemical's potential to occur in drinking water.
Environmental releases and production are less reflective of a chemical's potential to occur in
drinking water.  Accordingly, EPA selected the following hierarchy:

       Finished Water = Ambient Water > Environmental Release Data > Production Data.

EPA also decided that when multiple values exist for the chemicals within a given component of
the hierarchy, the most conservative would be used as the occurrence screening element.  For
example, in the case of a chemical that has finished water data and ambient water data, the
highest available numerical concentration value would be selected as the occurrence screening
data element.
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4.0  Criteria for Selecting a PCCL
The last step in the screening process was to use the intersections between health effects and
occurrence data elements to establish the criteria for moving chemicals from the Universe to a
PCCL. EPA grouped the Universe of chemicals that had values for health effects and occurrence
data elements using the screening framework described in Section 1.0. Because the chemicals
would be evaluated using a hierarchical approach for their occurrence elements, separate criteria
were developed for each of the occurrence elements.

To test the criteria, EPA used the set of 200 diagnostic chemicals. As stated in Section 3.0, the
set of diagnostic contaminants included some chemicals regulated through NPDWRs, some from
past CCLs, and a few drawn from the Universe because they had fairly complete data for all of
the occurrence data elements. The  selected regulated chemicals represented the characteristics of
chemicals that the screening process should move to the PCCL. Accordingly, the locations of
these chemicals in the completed screening framework were used to assist in placing the barrier
separating those chemical contaminants that would move to the PCCL from those that would not
be further evaluated.  The series of criteria are described in the following sections and
summarized in Appendix 1.
4.1  Finished and Ambient Water Concentration Data
As mentioned earlier, the finished and ambient water data are those most representative of
contaminants likely to be found in drinking water. For this reason EPA scrutinized these data
elements more closely than the other occurrence data elements. Initially, the placement of the
bold black line on Exhibit 10 was positioned so that it would move the regulated chemicals and
most of the past CCL chemicals to the PCCL. Past CCL contaminants that remained in the
Universe and did not pass on to the PCCL (fell to the gray side of the black line it) were ones
proven to be a poor candidates for regulation.

The second tool used to evaluate the position of the black line was the DWEL. The DWEL is
calculated by multiplying the RfD in mg/kg/day by an adult body weight of 70 kg and dividing
by a drinking water intake of 2 L/day (rounded to one significant figure).  The RfD is a dose that
is estimated to be without adverse effects for even sensitive populations. It includes a margin of
safety in the form of a composite uncertainty factor.  Most often, the uncertainty factor is a value
of 100, 300, 1000 or 3000. For this exercise, the DWEL was derived from the lower RfD value
in each Toxicity Category (See Exhibit 4) and then positioned  in the appropriate toxicity and
occurrence  cell of the framework

Since all Toxicity Category 1 contaminants are moved to the PCCL, it is the DWELs for the
Toxicity Category 2 to Toxicity Category 5 groupings that are  of interest for this analysis. The
calculated DWELs for the four toxicity categories of interest are as follows:

            Toxicity Category 2-4 |ig/L
            Toxicity Category 3-40 |ig/L
            Toxicity Category 4 - 2,000 |ig/L
            Toxicity Category 5 - 4,000 |ig/L
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As shown in Exhibit 10 by the asterisk in the cells, three of the four DWELs fall in the drinking
water concentration range of the first cell that moves to the PCCL. The DWEL for the Toxicity
Category 4 grouping is one unit above the divider. This analysis combined with the positions of
the chemicals in the occurrence test set of chemicals provided support for the position of the
PCCL selection line for finished and ambient water.
Exhibit 10: Criteria for Screening Health Effects and Water Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Finished Water - Concentration (ng/L)
0-<0.1





0.1-<1

 1
1



1-<10

*
1


10-<100


"=l
100-
<1,000




1K-<10K



*
1 1 .
>10K





4.2 Environmental Release Data
EPA used total releases to the environment (TRI) and pesticide application rate data to develop
the criteria for this category.  To aid in setting the limits for the release category, EPA started
with criteria used to develop the first CCL (CCL 1): that a chemical had to be released in
quantities greater than 400,000 Ibs/yr to surface waters.  EPA found that this CCL 1 criterion was
too stringent and only a few chemicals would have moved to the PCCL. Accordingly EPA used
the positions of the test set chemicals to position the Universe to PCCL barrier. The criterion for
moving a chemical with environmental release data to the PCCL is displayed in Exhibit 11.
Chemicals with environmental releases above the non-shaded area move to the PCCL.
Chemicals in the shaded area stay in the Universe.
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          Exhibit 11:  Criteria for Screening Health Effects and
                    Environmental Release Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Environmental Release Category -
Total Environmental Releases (Ibs/year)
0-<10





10-
<100





100 -<1K





1K-
<10K





10K-
<100K

H
1


100K<1M





1M-
<10M



^^^^^^a
>10M



1
4.3  Production Data
Similar to the release category, EPA started with the criteria used to develop CCL 1 that a
chemical be produced in quantities greater than 1 billion Ibs/yr. EPA decided that the CCL 1
guideline was too restrictive and proposed criteria that are less stringent for screening at this
stage of the process.  The criterion for moving a chemical, with production data, to the PCCL is
displayed in Exhibit 12. Chemicals above the line move to the PCCL. Chemicals in the shaded
areas remain in the CCL Universe.
          Exhibit 12:  Criteria for Screening Health Effects and
                           Production Categories
Screening Health
Effects Categories
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 5
Occurrence - Production Category (Ibs/year)
<10K





10K-
500K

'



>500K-
1M





>1M-
10M


|
1


>10M-
50M


H
1

>50M-
100M



a
>100M-
500M




,
I
>500M
-IB





>1B





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4.4  DBFS and Drinking Water Additives
The DBFs and drinking water additives that lacked quantitative occurrence data but fell in the
Toxicity Category 1 or Toxicity Category 2 groupings based on their toxicity were added to the
PCCL because of their high probability for being present in disinfected and treated drinking
water.
5.0  Efficacy of the Framework as a Screening Tool
The proposed screening approach provides a data-driven, objective, and transparent process for
selecting the PCCL from the Universe. Chemicals are screened based on their data elements and
not based on their names or CAS numbers for the initial PCCL screen.  All Toxicity Category 1
chemicals are captured no matter what the occurrence data element. The occurrence threshold
required for the PCCL selection become less inclusive as the contaminant toxicity decreases.
Once the initial screening is complete, the names of the PCCL chemicals are apparent. After the
initial screen, quality assurance measures were applied. EPA then conducted a detailed
examination of decisions that placed chemicals close to the borderline.

The screening approach on the CCL 3 Universe selected 532 chemical contaminants from the
approximately 6,000 chemicals in the CCL 3 Universe that were screened. (This includes
contaminant information that was compiled as part of EPA's nominations and surveillance
process.) Appendix 2 shows the contaminants that moved to the PCCL for additional
consideration and the data used in their screening.
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6.0  References

Health Canada. 2005. What is an LDso and LCso. Canadian Center for Occupational Health and
Safety. Ontario Canada. Available at. http://www.ccohs.ca/oshanswers/chemicals/ld50.html

Hodge, H.C. and J.H. Sterner.  1956.  Combined tabulation of toxicity classes. In:  Spector, W.S.,
ed.  Handbook of toxicology, Philadelphia, W.B. Saunders Company, Vol. 1.

International Toxicity Estimates for Risk (ITER). 2006. ITER Definitions (Classification).
Toxicology Excellence for Risk Assessment, Cincinnati, OH.
Available at: http://www/iter.ctcnet.net/publicurl.glossary.html

National Drinking Water Advisory Committee (NDWAC). 2004. CCL Classification Process.
Report from the NDWAC to the U.S. Environmental Protection Agency Office of Ground Water
and Drinking Water. May 19.

National Toxicology Program (NTP).  2005. Management Status Report Produced from the NTP
Chemtrack System. Central Data Management (EC-03) National Institute of Environmental
Health Services, Research Triangle Park, NC.

U.S. EPA. 1986. United States Environmental Protection Agency. Guidelines for carcinogen risk
assessment. Fed. Reg. 51(185):33992-34003.

U.S. EPA. 2005. United States Environmental Protection Agency. Guidelines for Carcinogen
Risk Assessment.  EPA/630/P-03/001B. Risk Assessment Forum, Washington, DC.

U.S. EPA. 2008a. United States Environmental Protection Agency. Contaminant Candidate List
3 Chemicals: Identifying the Universe. EPA Report 815-R-08-002. Draft. February, 2008.

U.S. EPA. 2008b. United States Environmental Protection Agency. Contaminant Candidate List
3 Chemicals: Classification of the PCCL to the CCL.  EPA Report 815-R-08-004. Draft.
February, 2008.
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7.0  Appendices

Appendix 1.  Criteria for Selecting the PCCL

   Contains the series of criteria used to select the PCCL from the CCL Chemical Universe.
   This criterion is based upon the following hierarchy:  Concentrations in Water > Releases to
   the Environment > Production

Concentrations in Water
   Toxicity Category 1 chemicals with any concentration
   Toxicity Category 2 chemicals with concentrations > 1 |j,g/l
   Toxicity Category 3 chemicals with concentrations > 10 ng/1
   Toxicity Category 4 chemicals with concentrations > 100 |j,g/l
   Toxicity Category 5 chemicals with concentrations > 1000 |j,g/l

Releases to the Environment
   Toxicity Category 1 chemicals with any amount released
   Toxicity Category 2 chemicals with releases/application > 10,000 Ibs/yr
   Toxicity Category 3 chemicals with releases/application > 100,000 Ibs/yr
   Toxicity Category 4 chemicals with releases/application > 1 M Ibs/yr
   Toxicity Category 5 chemicals with releases/application > 10 M Ibs/yr

Production
   Toxicity Category 1 chemicals with any amount produced
   Toxicity Category 2 chemicals production volumes > 500,000 Ibs/yr
   Toxicity Category 3 chemicals with production volumes > 10 M Ibs/yr
   Toxicity Category 4 chemicals with production volumes > 50 M Ibs/yr
   Toxicity Category 5 chemicals with production volumes > 100 M Ibs/yr
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Appendix 2.  Chemicals Passing Screening to the PCCL

The following table in Appendix 2 presents the CASRN number, names of the contaminants
listed on the PCCL, and the health effects and occurrence data elements that were used in their
screening. The data elements are described in the text of this report.

For the Health Effects Data Element, Cancer Studies NTP, the Value is shown as the National
Toxicology Program multi-species results (NTPMSR), representing the more detailed criteria
and data used to derive the Toxicity Screening Category. They are described in detail in the text.
For the Occurrence data elements, the Release data may be either national TRI data or pesticide
application data.  The notation "FW/AW" indicates the data are finished or ambient water data.
Also noted, for some pesticide degradates, data from the parent compound were used for
screening; for some contaminants supplemental data, compiled in the nominations and
surveillance process were also used.

Further data and information for the contaminants are available on the Contaminant Information
Sheets available in the CCL 3 water docket.
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                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
5989275
100641
630206
79345
75343
119642
87616
96184
95943
95636
122667
106876
106990
542927
77485
542756
99627
99650
105113
110634
110656
105088
123911
4904614
2432997
81492
71363
112301
112538
111706
592416
71410
71238
2439352
96139
95954
88062
105679
51285
121142
95807
95874
576261
87627
96297
78897
645625
123057
149575
104767
26266682
103117
7659861
818611
Substance Name
Cyclohexene, 1-methyl-4-(1-methylethenyl)-,
(4R)-
Cyclohexanone, oxime
Ethane, 1,1,1,2-tetrachloro-
Ethane, 1,1,2,2-tetrachloro-
Ethane, 1,1-dichloro-
Naphthalene, 1,2,3,4-tetrahydro-
Benzene, 1,2,3-trichloro-
Propane, 1,2,3-trichloro-
Benzene, 1,2,4,5-tetrachloro-
Benzene, 1,2,4-trimethyl-
Hydrazine, 1,2-diphenyl-
7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-
1 ,3-Butadiene
1 ,3-Cyclopentadiene
2,4-lmidazolidinedione, 1,3-dibromo-5,5-
dimethyl-
1-Propene, 1,3-dichloro-
Benzene, 1,3-bis(1-methylethyl)-
Benzene, 1,3-dinitro-
2,5-Cyclohexadiene-1 ,4-dione, dioxime
1,4-Butanediol
2-Butyne-1,4-diol
1 ,4-Cyclohexanedimethanol
1 ,4-Dioxane
1 ,5,9-Cyclododecatriene
Undecanoic acid, 11-amino-
9,10-Anthracenedione, 1-amino-2,4-dibromo-
1-Butanol
1-Decanol
1-Dodecanol
1-Heptanol
1-Hexene
1-Pentanol
1-Propanol
2-Propenoic acid, 2-(dimethylamino)ethyl
ester
1-Propanol, 2,3-dibromo-
Phenol, 2,4,5-trichloro-
Phenol, 2,4,6-trichloro-
Phenol, 2,4-dimethyl-
Phenol, 2,4-dinitro-
Benzene, 1-methyl-2,4-dinitro-
1,3-Benzenediamine, 4-methyl-
Phenol, 2,5-dimethyl-
Phenol, 2,6-dimethyl-
Benzenamine, 2,6-dimethyl-
2-Butanone, oxime
1-Propanol, 2-chloro-
2-Hexenal, 2-ethyl-
Hexanal, 2-ethyl-
Hexanoic acid, 2-ethyl-
1-Hexanol, 2-ethyl-
Hexenal, 2-ethyl-
2-Propenoic acid, 2-ethylhexyl ester
Acetic acid, mercapto-, 2-ethylhexyl ester
2-Propenoic acid, 2-hydroxyethyl ester
Common Name
(d)-Limonene
(Hydroxyimino)cyclohexane
1,1, 1 ,2-Tetrachloroethane
1 , 1 ,2,2-Tetrachloroethane
1,1-Dichloroethane
1 ,2,3,4-Tetrahydronaphthalene
1,2,3-Trichlorobenzene
1,2,3-Trichloropropane
1,2,4,5-Tetrachlorobenzene
1 , 2, 4-Trimethyl benzene
1 ,2-Diphenylhydrazine
1,2-Epoxy-4-(epoxyethyl)cyclohexane
1,3-Butadiene
1 ,3-Cyclopentadiene
1,3-Dibromo-5,5-dimethylhydantoin
1,3-Dichloropropene
1 ,3-Diisopropyl benzene
1,3-Dinitrobenzene
1,4-Benzoquinone dioxime
1,4-Butanediol
1,4-Butynediol
1 ,4-Cyclohexanedimethanol
1,4-Dioxane
1 ,5,9-Cyclododecatriene
1 1-Aminoundecanoic acid
1-Amino-2,4-dibromoanthraquinone
1-Butanol
1-Decanol
1-Dodecanol
1-Heptanol
1-Hexene
1-Pentanol
1-Propanol
2-(Dimethylamino)ethyl acrylate
2,3-Dibromopropanol
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4-Dimethylphenol
2,4-Dinitrophenol
2,4-Dinitrotoluene
2,4-Toluenediamine
2,5-Xylenol
2,6-Dimethylphenol
2,6-Xylidine
2-Butanone oxime
2-Chloro-1-propanol
2-Ethyl-3-propylacrolein
2-Ethylhexanal
2-Ethylhexanoic acid
2-Ethylhexanol
2-Ethylhexenal
2-Ethylhexyl acrylate
2-Ethylhexyl thioglycolate
2-Hydroxyethyl acrylate
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Classification, EPA
Lethal Dose 50 (LD50)
Tolerable Daily Intake (TDI)
Cancer Studies, NTP
Reference Dose (RfD)
TD50
Risk Specific Dose (RSD)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
No Observed Adverse Effect Level (NOAEL)
Cancer Studies, NTP
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Value
NTPMSR
17.9
NTPMSR
0.00005
C
2,860
0.0015
NTPMSR
0.0003
4,350
0.00001
NTPMSR
NTPMSR
113
0.44
NTPMSR
0.25
0.0001
NTPMSR
200
2
1,600
NTPMSR
1,780
NTPMSR
NTPMSR
0.2
4,720
1,170
0.0251
1,000
200
600
4
NTPMSR
0.3
NTPMSR
0.02
0.0006
NTPMSR
NTPMSR
383
0.0006
NTPMSR
4
100
3,000
2,600
885
2,053
2,005
3
303
300
Units

mg/kg-day

mg/kg-day

mg/kg
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day


mg/kg
mg/kg-day

mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg

mg/kg


mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day

mg/kg-day

mg/kg-day
mg/kg-day


mg/kg
mg/kg-day

mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg
Toxicity Screening
Category
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 5
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
1.0
>100M-500M
18
200
500
>50M-100M
15
3,000
>1M-10M
260
0
10K-500K
1,964,956
>10M-50M
>500K-1M
39
>1M-10M
528,962
>500K-1M
>500M-1B
>100M-500M
>50M-100M
821,067
>50M-100M
>10M-50M
10K-500K
17,648,846
>50M-100M
>50M-100M
>500K-1M
>500M-1B
>10M-50M
>100M-500M
>10M-50M
10K-500K
18,879
0
168,992
0.0
333
11,834
>10M-50M
>100M-500M
5,256
>10M-50M
>500M-1B
>50M-100M
>50M-100M
>50M-100M
>500M-1B
>100M-500M
>100M-500M
>10M-50M
>10M-50M
                                                                                     Page 23 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
149304
109864
78784
109068
91598
135193
79469
127060
107186
616455
1948330
91941
612828
760236
3401807
563473
16655826
108996
100549
553264
101804
80079
101611
101688
101779
92671
101542
95830
5216251
123422
108112
6610293
98533
100403
95794
16219753
99592
99558
71751412
30560191
75070
60355
64197
108247
34256821
187022113
184992444
67641
75865
75058
107028
79107
Substance Name
2(3H)-Benzothiazolethione
Ethanol, 2-methoxy-
Butane, 2-methyl-
Pyridine, 2-methyl-
2-Naphthalenamine
2-Naphthalenol
Propane, 2-nitro-
2-Propanone, oxime
2-Propen-1-ol
2-Pyrrolidinone
1 ,4-Benzenediol, 2-(1 , 1-dimethylethyl)-
1,r-Biphenyl]-4,4'-diamine, 3,3'-dichloro-
1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-,
dihydrochloride
1-Butene, 3,4-dichloro-
Benzoic acid, 3,6-dichloro-2-hydroxy-
1-Propene, 3-chloro-2-methyl-
3,7-Benzofurandiol, 2,3-dihydro-2,2-dimethyl
, 7-(methylcarbamate)
Pyridine, 3-methyl-
3-Pyridinecarbonitrile
4,4'-Bipyridine
Benzenamine, 4,4'-oxybis-
Benzene, 1,1'-sulfonylbis[4-chloro-
Benzenamine, 4,4'-methylenebis[N,N-
dimethyl-
Benzene, 1,1'-methylenebis[4-isocyanato-
Benzenamine, 4,4'-methylenebis-
1,1 '-Biphenyl]-4-amine
1,4-Benzenediamine, N-phenyl-
1,2-Benzenediamine, 4-chloro-
Benzene, 1-chloro-4-(trichloromethyl)-
2-Pentanone, 4-hydroxy-4-methyl-
2-Pentanol, 4-methyl-
Hydrazinecarbothioamide, N-methyl-
Cyclohexanone, 4-(1 , 1-dimethylethyl)-
Cyclohexene, 4-ethenyl-
Benzenamine, 5-chloro-2-methyl-
Bicyclo[2.2. 1 ]hept-2-ene, 5-ethylidene-
Benzenamine, 2-methoxy-5-nit.ro-
Benzenamine, 2-methyl-5-nitro-
Avermectin B1
Phosphoramidothioic acid, acetyl-, O,S-
dimethyl ester
Acetaldehyde
Acetamide
Acetic acid
Acetic acid, anhydride
Acetamide, 2-chloro-N-(ethoxymethyl)-N- (2-
ethyl-6-methylphenyl)-
Acetochlor ethanesulfonic acid
Acetochlor oxanilic acid
2-Propanone
Propanenitrile, 2-hydroxy-2-methyl-
Acetonitrile
2-Propenal
2-Propenoic acid
Common Name
2-Mercaptobenzothiazole
2-Methoxyethanol
2-Methylbutane
2-Methylpyridine
2-Naphthalenamine
2-Naphthalenol
2-Nitropropane
2-Propanone oxime
2-Propen-1-ol
2-Pyrrolidone
2-tert-Butylhydroquinone
3,3-Dichlorobenzidine
3,3'-Dimethylbenzidine dihydrochloride
3,4-Dichloro-1-butene
3,6-Dichlorosalicylic acid
3-Chloro-2-methyl-1-propene
3-Hydroxycarbofuran
3-Methylpyridine
3-Pyridinecarbonitrile
4,4'-Bipyridine
4,4'-Diaminodiphenyl ether
4,4'-Dichlorodiphenyl sulfone
4,4'-Methylenebis(N,N-
dimethyl)benzenamine
4,4'-Methylenedi(phenyl isocyanate)
4,4'-Methylenedianiline
4-Aminobiphenyl
4-Aminodiphenylamine
4-Chloro-1 ,2-diaminobenzene
4-Chlorobenzotrichloride
4-Hydroxy-4-methyl-2-pentanone
4-Methyl-2-pentanol
4-Methyl-3-thiosemicarbazide
4-tert-Butylcyclohexanone
4-Vinylcyclohexene
5-Chloro-o-toluidine
5-Ethylidene-2-norbornene
5-Nitro-o-anisidine
5-Nitro-o-toluidine
Abamectin
Acephate
Acetaldehyde
Acetamide
Acetic acid
Acetic anhydride
Acetochlor
Acetochlor ethanesulfonic acid (ESA)
Acetochlor oxanilic acid (OA)
Acetone
Acetone cyanohydrin
Acetonitrile
Acrolein
Acrylic acid
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
TD50
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, EPA
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Maximum Recommended Daily Dose (MRDD)
Risk Specific Dose (RSD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Classification, EPA
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Effect Level (LOEL)
Cancer Classification, EPA
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Value
344
0.001
357.1
0.0099
1
0.437
B2
12.1
0.05
328
0.2
0.000022
NTPMSR
2
3
NTPMSR
7
400
5
172
NTPMSR
0.005
NTPMSR
2,200
4.3
1
150
NTPMSR
B2
30
2,600
14
5,000
NTPMSR
NTPMSR
4
NTPMSR
NTPMSR
2
0.12
B2
180
1.47
1,780
0.02
Parent data
Parent data
100
0.0008
0.006
0.0005
53
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day

mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day

mg/kg
mg/kg
mg/kg-day
mg/kg

mg/kg-day

mg/kg
mg/kg-day

mg/kg-day


mg/kg-day
mg/kg
mg/kg
mg/kg


mg/kg-day


mg/kg
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 5
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Value
644,590
153,774
> 1B
27,839
5
>1M-10M
25,344
>1M-10M
604,872
>10M-50M
>1M-10M
2
10K-500K
>100M-500M
>10M-50M
6,635
66.3
>10M-50M
>10M-50M
>10M-50M
985
>10M-50M
10K-500K
>100M-500M
168,919
1
>50M-100M
10K-500K
>10M-50M
>100M-500M
>100M-500M
>1M-10M
>500M-1B
>1M-10M
10K-500K
>10M-50M
10K-500K
255
14,965
2,467,744
14,683,890
1,202,667
> 1B
> 1B
30.4
Parent
Parent
1,806
106,961
12,784,367
3.4
6,817,569
                                                                                     Page 24 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
107131
124049
111693
142363539
171262172
309002
96242
319846
98851
98839
834128
33089611
7664417
1111780
7783188
62533
142041
100663
50782
492808
86500
741582
25057890
100527
92875
271896
65850
95147
98077
100516
100447
108601
111444
577117
542881
7440428
314409
7726956
108861
Substance Name
2-Propenenitrile
Hexanedioic acid
Hexanedinitrile
Ethanesulfonic acid, 2-[(2,6-
diethylphenyl)(methoxymethyl)amino]-2-oxo-
Alachlor oxanilic acid
1 ,4:5,8-Dimethanonaphthalene,
1 ,2,3,4, 10, 10-hexachloro-1 ,4,4a,5,8,8a-
hexahydro-,
(1.alpha.,4.alpha.,4a.beta.,5.alpha.,8.alpha.,
Sa.beta.)-
1,2-Propanediol, 3-chloro-
Cyclohexane, 1 ,2,3,4,5,6-hexachloro-,
(1. alpha., 2. alpha. ,3. beta. ,4. alpha., 5. beta., 6. b
eta.)-
Benzenemethanol, .alpha. -methyl-
Benzene, (1-methylethenyl)-
1 ,3,5-Triazine-2,4-diamine, N-ethyl-N'-(1-
methylethyl)-6-(methylthio)-
Methanimidamide, N'-(2,4-dimethylphenyl)-N
](2,4-dimethylphenyl)imino]methyl]-N-methyl
Ammonia
Carbamic acid, monoammonium salt
fhiosulfuric acid (H2S2O3), diammonium
salt
Benzenamine
Benzenamine, hydrochloride
Benzene, methoxy-
Benzoic acid, 2-(acetyloxy)-
Benzenamine, 4,4'-carbonimidoylbis[N,N-
dimethyl-
Phosphorodithioic acid, O,O-dimethyl S-[(4-
oxo-1 ,2,3-benzotriazin-3(4H)-yl)methyl] ester
Phosphorodithioic acid, O,O-bis(1-
methylethyl) S-[2-
Xphenylsulfonyl)amino]ethyl] ester
1 H-2, 1 ,3-Benzothiadiazin-4(3H)-one, 3-(1-
methylethyl)-, 2,2-dioxide
Benzaldehyde
1 , 1'-Biphenyl]-4,4'-diamine
Benzofuran
Benzole acid
1 H-Benzotriazole
Benzene, (trichloromethyl)-
Benzenemethanol
Benzene, (chloromethyl)-
Propane, 2,2'-oxybis[1-chloro-
Ethane, 1,1'-oxybis[2-chloro-
Butanedioic acid, sulfo-, 1 ,4-bis(2-ethylhexyi;
ester, sodium salt
Methane, oxybis[chloro-
Boron
2,4(1 H,3H>Pyrimidinedione, 5-bromo-6-
methyl-3-(1-methylpropyl)-
Bromine
Benzene, bromo-
Common Name
Acrylonitrile
Adipic acid
Adiponitrile
Alachlor ethanesulfonic acid (ESA)
Alachlor oxanilic acid (OA)
Aldrin
alpha-Chlorohydrin
alpha-Hexachlorocyclohexane
alpha-Methylbenzenemethanol
alpha-Methylstyrene
Ametryn
Amitraz
Ammonia
Ammonium carbamate
Ammonium thiosulfate
Aniline
Aniline hydrochloride
Anisole
Aspirin
Auramine
Azinphos-methyl
Bensulide
Bentazon
Benzaldehyde
Benzidine
Benzofuran
Benzole acid
Benzotriazole
Benzotrichloride
Benzyl alcohol
Benzyl chloride
Bis(2-chloro-1-methylethyl) ether
Bis(2-chloroethyl) ether
Bis(2-ethylhexyl) sodium sulfosuccinate
Bis(chloromethyl) ether
Boron
Bromacil
Bromine
Bromobenzene
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
TD50
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Classification, EPA
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
TD50
Risk Specific Dose (RSD)
Cancer Studies, NTP
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Maximum Recommended Daily Dose (MRDD)
Risk Specific Dose (RSD)
Cancer Studies, NTP
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Minimal Risk Level (MRL)
Cancer Classification, EPA
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Value
0.000019
4,000
22
Parent data
Parent data
0.00003
26
0.000002
458
0.07
0.009
0.25
6.2
681
1,098
B2
NTPMSR
0.65
0.0021
1
0.91
271
0.03
1,490
0.000000043
NTPMSR
34
0.60
0.0000008
5
0.00006
NTPMSR
0.0000091
0.5
0.000000045
0.01
C
440
0.02
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg


mg/kg-day
mg/kg-day

mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
Toxicity Screening
Category
Toxicity Category 1
Toxicity Category 5
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Value
7,925,644
> 1B
> 1B
Parent
Parent
4.4
>1M-10M
0.21
> 1B
>100M-500M
446,546
137,397
34,000
> 1B
>50M-100M
937,263
10K-500K
>500K-1M
10K-500K
0
3.37
546,600
11.46
>10M-50M
83
10K-500K
>100M-500M
>1M-10M
745
>10M-50M
18,750
883
478
>10M-50M
0
3,950
57
381,257
40
                                                                                     Page 25 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
74964
109740
85687
25013165
107926
106310
6459945
2429745
28407376
2832408
5160021
842079
471341
1305620
1592230
105602
133062
63252
10605217
75150
120809
75694
75718
115286
54593838
79049
510156
75003
74873
107302
25167800
76062
126998
1897456
104552
Substance Name
Ethane, bromo-
Butanenitrile
1 ,2-Benzenedicarboxylic acid, butyl
phenylmethyl ester
Phenol, (1,1-dimethylethyl)-4-methoxy-
Butanoic acid
Butanoic acid, anhydride
1 ,3-Naphthalenedisulfonic acid, 8-[[3,3'-
dimethyl-4'-[[4-[[(4-
methylphenyl)sulfonyl]oxy]phenyl]azo][ 1,1'-
biphenyl]-4-yl]azo]-7-hydroxy-, disodium salt
2,7-Naphthalenedisulfonic acid, 3,3'-[(3,3'-
dimethoxy[1 , 1-biphenyl J-4,41-
diyl)bis(azo)]bis[5-amino-4-hydroxy-,
tetrasodium salt
Cuprate(4-), [.mu.-[[3,3'-[[3,3'-di(hydroxy-
. kappa. O)[1,1'-biphenyl]-4, 4'-diyl]bis(azo-
. kappa. N1 )]bis[5-amino-4-(hydroxy-
.kappa.O)-2,7-naphthalenedisulfonato]](8-
)]]di-, tetrasodium
Acetamide, N-[4-[(2-hydroxy-5-
methylphenyl)azo]phenyl]-
Benzenesulfonic acid, 5-chloro-2-[(2-hydroxy
1-naphthalenyl)azo]-4-methyl-, barium salt
(2:1)
2-Naphthalenol, l-(phenylazo)-
Carbonic acid calcium salt (1:1)
Calcium hydroxide (Ca(OH)2)
Octadecanoic acid, calcium salt
2H-Azepin-2-one, hexahydro-
1 H-lsoindole-1 ,3(2H)-dione, 3a,4,7,7a-
tetra hydro- 2-[(trichloromethyl)thio]-
1-Naphthalenol, methylcarbamate
Carbamic acid, 1H-benzimidazol-2-yl-,
methyl ester
Carbon disulfide
1,2-Benzenediol
Methane, trichlorofluoro-
Methane, dichlorodifluoro-
Bicyclo[2.2. 1 ]hept-5-ene-2,3-dicarboxylic
acid, 1,4, 5,6,7, 7-hexachloro-
Phosphorothioic acid, O,O-diethyl O-(1, 2,2,2
tetrachloroethyl) ester
Acetyl chloride, chloro-
Benzeneacetic acid, 4-chloro-.alpha.-(4-
chlorophenyl)-.alpha.-hydroxy-, ethyl ester
Ethane, chloro-
Methane, chloro-
Methane, chloromethoxy-
Phenol, chloro-
Methane, trichloronitro-
1 ,3-Butadiene, 2-chloro-
1 ,3-Benzenedicarbonitrile, 2,4,5,6-
tetrachloro-
2-Propenal, 3-phenyl-
Common Name
Bromoethane
Butanenitrile
Butyl benzyl phthalate
Butylated hydroxyanisole
Butyric acid
Butyric anhydride
C.I. Acid Red 114, disodium salt
C.I. Direct Blue 15
C.I. Direct Blue 218
C.I. Disperse Yellow 3
C.I. Pigment Red 53, barium salt (2:1)
C.I. Solvent Yellow 14
Calcium carbonate
Calcium hydroxide
Calcium octadecanoate
Caprolactam
Captan
Carbaryl
Carbendazim
Carbon disulfide
Catechol
CFC-11
CFC-12
Chlorendic acid
Chlorethoxyfos
Chloroacetyl chloride
Chlorobenzilate
Chloroethane
Chloromethane (Methyl chloride)
Chloromethyl methyl ether
Chlorophenol
Chloropicrin
Chloroprene
Chlorothalonil
Cinnamaldehyde
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Adverse Effect Level (NOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Minimal Risk Level (MRL)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Adverse Effect Level (NOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Classification, EPA
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Value
NTPMSR
28
NTPMSR
0.25
2,000
8,790
NTPMSR
NTPMSR
NTPMSR
NTPMSR
NTPMSR
NTPMSR
60,000
7,300
10,000
50
NTPMSR
0.23
0.59
0.01
84.7
349
15
NTPMSR
0.05
208
NTPMSR
NTPMSR
0.004
A
0.3
32
NTPMSR
NTPMSR
0.21
Units

mg/kg

mg/kg-day
mg/kg
mg/kg






mg/kg-day
mg/kg
mg/kg
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg


mg/kg-day

mg/kg-day
mg/kg-day


mg/kg-day
Toxicity Screening
Category
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 5
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 5
Toxicity Category 5
Toxicity Category 5
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Value
>500K-1M
>500K- 1M
>50M-100M
1.2
>100M-500M
>100M-500M
10K-500K
>500K-1M
2,609
0
>1M-10M
10K-500K
>100M-500M
>100M-500M
>100M-500M
> 1B
4,001,523
33.5
>1M-10M
34
35,911
1,444
404.9
0
253,345
>100M-500M
5
288.2
550
1,085
43,439
13,912,578
925,010
0.71
>1M-10M
                                                                                     Page 26 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
77929
110429624
81777891
7440484

91645
1319773
15096523
80159
135206
13752517
21725462
108805
108770
113136779
110827
108930
108941
108918
68359375
52315078
66215278
1861321

1163195
541026
6190654
1007289
50997
142223
7398698
333415

74953
683181
818086
99309
Substance Name
1 ,2,3-Propanetricarboxylic acid, 2-hydroxy-
Clethodim
3-lsoxazolidinone, 2-[(2-chlorophenyl)methyl
4,4-dimethyl-
Cobalt
Co bait compounds
2H-1-Benzopyran-2-one
Phenol, methyl-
Cryolite (Na3(AIF6))
Hydroperoxide, 1-methyl-1-phenylethyl
Benzenamine, N-hydroxy-N-nitroso-,
ammonium salt
Morpholine, 4-[(4-
morpholinylthio)thioxomethyl]-
Propanenitrile, 2-[[4-chloro-6-(ethylamino)-
1,3,5-triazin-2-yl]amino]-2-methyl-
1 ,3,5-Triazine-2,4,6(1 H,3H,5H)-trione
1,3,5-Triazine, 2,4,6-trichloro-
Cyclopropanecarboxylic acid, 1-[[(2,4-
dichlorophenyl)amino]carbonyl]-
Cyclohexane
Cyclohexanol
Cyclohexanone
Cyclohexanamine
Cyclopropanecarboxylic acid, 3-(2,2-
dichloroethenyl)-2,2-dimethyl-, cyano(4-
fluoro-3-phenoxyphenyl)methyl ester
Cyclopropanecarboxylic acid, 3-(2,2-
dichloroethenyl)-2,2-dimethyl-, cyano(3-
3henoxyphenyl)methyl ester
1 ,3,5-Triazine-2,4,6-triamine, N-cyclopropyl-
1 ,4-Benzenedicarboxylic acid, 2,3,5,6-
tetrachloro-, dimethyl ester
DCPA mono/di-acid degradate
Benzene, 1,1'-oxybis[2, 3,4,5, 6-pentabromo-
Cyclopentasiloxane, decamethyl-
1 ,3,5-Triazine-2,4-diamine, 6-chloro-N-(1-
methylethyl)-
1 ,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-
D-Glucose
2,5,8,10-Tetraoxatridec-12-enoic acid, 9-oxo
, 2-propenyl ester
2-Propen-1-aminium, N,N-dimethyl-N-2-
propenyl-, chloride
Phosphorothioic acid, O,O-diethyl O-[6-
methyl-2-(1-methylethyl)-4-pyrimidinyl] ester
Diazinon oxygen analog
Methane, dibromo-
Stannane, dibutyldichloro-
Stannane, dibutyloxo-
Benzenamine, 2,6-dichloro-4-nitro-
Common Name
Citric acid
Clethodim
Clomazone
Cobalt
Cobalt compounds
Coumarin
Cresol
Cryolite
Cumene hydroperoxide
Cupferron
Cure-Rite 18
Cyanazine
Cyanuric acid
Cyanuric chloride
Cyclanilide
Cyclohexane
Cyclohexanol
Cyclohexanone
Cyclohexylamine
Cyfluthrin
Cypermethrin
Cyromazine
Dacthal
Dacthal mono/di-acid degradate
Decabromodiphenyl ether
Decamethylcyclopentasiloxane
Desethylatrazine
Desisopropylatrazine
D-Glucose
Diallyl glycol carbonate
Diallyldimethylammonium chloride
Diazinon
Diazinon oxygen analog
Dibromomethane
Dibutyltin dichloride
Dibutyltin oxide
Dichloran
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Maximum Recommended Daily Dose (MRDD)
Acceptable Daily Intake (ADI)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
TD50
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Adverse Effect Level (NOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Maximum Recommended Daily Dose (MRDD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Acceptable Daily Intake (ADI)
Value
100
0.01
1,369
0.04
150
13.9
177
23.1
382
NTPMSR
90.8
0.98
600
350
208
813
1,400
462
11
0.025
24.6
0.75
0.01
Parent data
0.01
24,134
Parent data
Parent data
100
279
1,000
0.00009
Parent data
0.01
0.05
0.17
0.01
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 4
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 5
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 5
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW
FW/AW
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
>100M-500M
672,189
2,536,701
684
6,910,811
>1M-10M
1,475,929
2,565,970
443,722
0
>1M-10M
160
>100M-500M
>100M-500M
177,474
4,761,999
4,538,466
> 1B
>10M-50M
178,171
188,403
14,328
100
190
953,472
>100M-500M
Parent
Parent
>500M-1B
>10M-50M
>100M-500M
19
Parent
21.1
>1M-10M
>1M-10M
189,096
                                                                                     Page 27 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
62737
115322
141662
77736
60571
111422
64675
25340174
111466
112345
111400
68479981
43222486
101906
55290647
60515
868859
112185
77781
120616
124403
75785
753731
25321146
122394
142847
25265718
2764729
928723
298044
330541
27176870
2439103
115297
759944
Substance Name
Phosphoric acid, 2,2-dichloroethenyl
dimethyl ester
Benzenemethanol, 4-chloro-.alpha.-(4-
chlorophenyl)-.alpha.-(trichloromethyl)-
Phosphoric acid, 3-(dimethylamino)-1-methyl
3-oxo-1-propenyldimethyl ester, (E)-
4,7-Methano-1H-indene, 3a,4,7,7a-
tetrahydro-
2,7:3,6-Dimethanonaphth(2,3-b)oxirene,
3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-
octahydro-,
(1 a. alpha., 2. beta. ,2a. alpha., 3. beta., 6. beta. ,6
a. alpha. ,7. beta., 7a. alpha. )-
Ethanol, 2,2'-iminobis-
Sulfuric acid, diethyl ester
Benzene, diethyl-
Ethanol, 2,2'-oxybis-
Ethanol, 2-(2-butoxyethoxy)-
1 ,2-Ethanediamine, N-(2-aminoethyl)-
Benzenediamine, ar,ar-diethyl-ar-methyl-
1 H-Pyrazolium, 1 ,2-dimethyl-3,5-diphenyl-,
methyl sulfate
Oxirane, 2,2'-[1,3-
phenylenebis(oxymethylene)]bis-
1,4-Dithiin, 2,3-dihydro-5,6-dimethyl-, 1,1,4,4
tetraoxide
Phosphorodithioic acid, O,O-dimethyl S-[2-
(methylamino)-2-oxoethyl] ester
Phosphonic acid, dimethyl ester
1-Dodecanamine, N,N-dimethyl-
Sulfuric acid, dimethyl ester
1 ,4-Benzenedicarboxylic acid, dimethyl ester
Methanamine, N-methyl-
Silane, dichlorodimethyl-
Stannane, dichlorodimethyl-
Benzene, methyldinitro-
Benzenamine, N-phenyl-
1-Propanamine, N-propyl-
Propanol, oxybis-
Dipyrido[1,2-a:2',1'-c]pyrazinedium, 6,7-
dihydro-
Glycine, N-(carboxymethyl)-, disodium salt
Phosphorodithioic acid, O,O-diethyl S-[2-
(ethylthio)ethyl] ester
Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl-
Benzenesulfonic acid, dodecyl-
Guanidine, dodecyl-, monoacetate
6,9-Methano-2,4,3-benzodioxathiepin,
6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-
hexahydro-, 3-oxide
Carbamothioic acid, dipropyl-, S-ethyl ester
Common Name
Dichlorvos
Dicofol
Dicrotophos
Dicyclopentadiene
Dieldrin
Diethanolamine
Diethyl sulfate
Diethylbenzene
Diethylene glycol
Diethylene glycol monobutyl ether
Diethylenetriamine
Diethyltoluenediamine
Difenzoquat methyl sulfate
Diglycidyl resorcinol ether
Dimethipin
Dimethoate
Dimethyl hydrogen phosphite
Dimethyl laurylamine
Dimethyl sulfate
Dimethyl terephthalate
Dimethylamine
Dimethyldichlorosilane
Dimethyltin dichloride
Dinitrotoluene
Diphenylamine
Dipropylamine
Dipropylene glycol
Diquat
Disodium iminodiacetate
Disulfoton
Diuron
Dodecylbenzenesulfonic acid
Dodine
Endosulfan
EPTC
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Risk Specific Dose (RSD)
TD50
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Cancer Classification, IARC
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Classification, IARC
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
No Observed Adverse Effect Level (NOAEL)
Reference Dose (RfD)
Value
0.00003
32.9
0.0001
0.03
0.00005
20
2A
0.64
1,660
0.01
10
472
206
NTPMSR
0.02
0.0002
NTPMSR
740
2A
NTPMSR
0.347
800
73.9
0.00001
0.83
5
14,850
30
8,070
0.00004
0.63
650
0.004
0.7
0.025
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg

mg/kg-day
mg/kg-day

mg/kg


mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 5
Toxicity Category 2
Toxicity Category 5
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Value
264
788,527
360,513
392,668
5.6
1,396,761
10,644
>10M-50M
>500M-1B
>100M-500M
>100M-500M
>10M-50M
347,066
1
283,076
1,896,947
>1M-10M
>50M-100M
10,221
> 1B
618,880
>500M-1B
>10M-50M
6,802
414,131
>10M-50M
>100M-500M
267,442
>500M-1B
3.81
23.3
>100M-500M
151,870
1,604,700
40
                                                                                     Page 28 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
66230044
140670
64175
16672870
563122
13194484
141786
140885
75047
107211
111762
75218
96457
107153
60004
22224926
13356086
14484641
2164172
144490
72178020
944229
50000
23422539
64186
110009
98011
96480
7440564
111308
56815
556525
107222
74975
75887
75456
142825
87683
67721
4719044
111499
822060
Substance Name
Benzeneacetic acid, 4-chloro-. alpha. -(1-
methylethyl)-, cyano(3-
phenoxyphenyl)methyl ester, [S-(R*,R*)J-
Benzene, 1-methoxy-4-(2-propenyl)-
Ethanol
Phosphonic acid, (2-chloroethyl)-
Phosphorodithioic acid, S,S'-methylene
O,O,O',O'-tetraethyl ester
Phosphorodithioic acid, O-ethyl S,S-dipropyl
ester
Acetic acid ethyl ester
2-Propenoic acid, ethyl ester
Ethanamine
1,2-Ethanediol
Ethanol, 2-butoxy-
Oxirane
2-I midazolidinethione
1,2-Ethanediamine
Glycine, N,N'-1 ,2-ethanediylbis[N-
(carboxymethyl)-
Phosphoramidic acid, (1-methylethyl)-, ethyl
3-methyl-4-(methylthio)phenyl ester
Distannoxane, hexakis(2-methyl-2-
phenylpropyl)-
I ron, tris(dimethylcarbamodithioato-
.kappa.S,.kappa.S')-, (OC-6-11)-
Urea, N,N-dimethyl-N'-[3-
(trifluoromethyl)phenylj-
Acetic acid, fluoro-
Benzamide, 5-[2-chloro-4-
(trifluoromethyl)phenoxyJ-N-(methylsulfonyl)-
2-nitro-
Phosphonodithioic acid, ethyl-, O-ethyl S-
phenyl ester
Formaldehyde
Methanimidamide, N,N-dimethyl-N'-[3-
](methylamino)carbonyl]oxy]phenyl]-,
monohydrochloride
Formic acid
Furan
2-Furancarboxaldehyde
2(3H)-Furanone, dihydro-
Germanium
Pentanedial
1,2,3-Propanetriol
Oxiranemethanol
Ethanedial
Methane, bromochloro-
Ethane, 2-chloro-1 ,1 , 1-trifluoro-
Methane, chlorodifluoro-
Heptane
1 ,3-Butadiene, 1,1, 2,3,4, 4-hexachloro-
Ethane, hexachloro-
1 ,3,5-Triazine-1 ,3,5(2H,4H,6H)-triethanol
1 H-Azepine, hexahydro-
Hexane, 1 ,6-diisocyanato-
Common Name
Esfenvalerate
Estragole
Ethanol
Ethephon
Ethion
Ethoprop
Ethyl acetate
Ethyl acrylate
Ethylamine
Ethylene glycol
Ethylene glycol monobutyl ether
Ethylene oxide
Ethylene thiourea
Ethylenediamine
Ethylenediaminetetraacetic acid
Fenamiphos
Fenbutatin oxide
Ferbam
Fluometuron
Fluoroacetic acid
Fomesafen
Fonofos
Formaldehyde
Formetanate hydrochloride
Formic acid
Furan
Furfural
gamma-Butyrolactone
Germanium
Glutaraldehyde
Glycerine
Glycidol
Glyoxal
Halon 1011
HCFC-133a
HCFC-22
Heptane
Hexachlorobutadiene
Hexachloroethane
Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-
triazine
Hexahydroazepine
Hexamethylene-1 ,6-diisocyanate
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Effect Level (LOEL)
Reference Dose (RfD)
Acceptable Daily Intake (ADI)
Maximum Recommended Daily Dose (MRDD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Tolerable Daily Intake (TDI)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Classification, IARC
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Risk Specific Dose (RSD)
No Observed Effect Level (NOEL)
TD50
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Maximum Recommended Daily Dose (MRDD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Reference Dose (RfD)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Value
325
51.8
1.43
0.5
0.0005
0.0004
25
NTPMSR
400
0.05
5.1
1
0.00008
0.09
30
0.00025
0.03
0.003
0.01
0.47
0.00005
0.2
2.19
18
360
NTPMSR
NTPMSR
160.7
0.32
0.3
999
NTPMSR
200
0.01
87.3
13.5
2,857
0.0002
NTPMSR
1.99
20.7
350
Units
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day


mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg
mg/kg
Toxicity Screening
Category
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 5
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
229,386
>1M-10M
> 1B
5,419,825
505,639
1.95
>100M-500M
152,024
>10M-50M
10,076,483
>100M-500M
374,110
299
>100M-500M
>10M-50M
728,266
265,856
317,819
37.8
>1M-10M
1,102,750
1.2
26,992,234
134,821
10,144,003
>10M-50M
>10M-50M
>50M-100M
225.1
>10M-50M
>100M-500M
10K-500K
>10M-50M
210
56,253
7,075,769
>100M-500M
10
1,015
>10M-50M
>1M-10M
>50M-100M
                                                                                     Page 29 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
124094
100970
110543
2691410
302012
7647010
6386385
7783064
123319
868779
13463406
78831
115117
110190
78820
29590429
121915
78795
67630
625558
75310
6846500
77501634
78977
91465086
1335326
330552
554132
7447418
121755
108316
123331
109773
12427382
94746
108394
541731
108781
24307264
68111
150505
79390
79414
126987
Substance Name
1,6-Hexanediamine
1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane
Hexane
1,3,5,7-Tetrazocine, octahydro-1, 3,5,7-
tetranitro-
Hydrazine
Hydrochloric acid
Benzenepropanoic acid, 3,5-bis(1 ,1-
dimethylethyl)-4-hydroxy-, methyl ester
Hydrogen sulfide (H2S)
1,4-Benzenediol
2-Propenoic acid, 2-methyl-, 2-hydroxyethyl
ester
Iron carbonyl (Fe(CO)5), (TB-5-1 1>
1-Propanol, 2-methyl-
1-Propene, 2-methyl-
Acetic acid, 2-methylpropyl ester
Propanenitrile, 2-methyl-
2-Propenoic acid, isooctyl ester
1 ,3-Benzenedicarboxylic acid
1 ,3-Butadiene, 2-methyl-
2-Propanol
Formic acid, 1-methylethyl ester
2-Propanamine
Propanoic acid, 2-methyl-, 2,2-dimethyl-1-(1-
methylethyl)-1 ,3-propanediyl ester
Benzole acid, 5-[2-chloro-4-
(trifluoromethyl)phenoxy]-2-nitro-, 2-ethoxy-1
methyl-2-oxoethyl ester
Propanenitrile, 2-hydroxy-
Cyclopropanecarboxylic acid, 3-2-chloro-
3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-
cyano(3-phenoxyphenyl)methyl ester,
1 .alpha.(S*),3.alpha.(Z)-(.+ -.>
Lead, bis(acetato-. kappa. O)tetrahydroxytri-
Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-
methyl-
Carbonic acid, dilithium salt
Lithium chloride (LiCI)
Butanedioic acid,
Xdimethoxyphosphinothioyl)thio]-, diethyl
ester
2,5-Furandione
3,6-Pyridazinedione, 1 ,2-dihydro-
Propanedinitrile
Manganese, [[1,2-
ethanediylbis(carbamodithioato)](2-)]-
Acetic acid, (4-chloro-2-methylphenoxy)-
Phenol, 3-methyl-
Benzene, 1,3-dichloro-
1 ,3,5-Triazine-2,4,6-triamine
Piperidinium, 1,1-dimethyl-, chloride
Acetic acid, mercapto-
Phosphorotrithious acid, tributyl ester
2-Propenamide, 2-methyl-
2-Propenoic acid, 2-methyl-
2-Propenenitrile, 2-methyl-
Common Name
Hexamethylenediamine
Hexamethylenetetramine
Hexane
HMX
Hydrazine
Hydrochloric acid
Hydrocinnamic acid, 3,5-di-tert-butyl-4-
hydroxy-, methyl ester
Hydrogen sulfide
Hydroquinone
Hydroxyethyl methacrylate
ron pentacarbonyl
sobutanol
sobutene
sobutyl acetate
sobutyronitrile
sooctyl acrylate
sophthalic acid
soprene
sopropanol
sopropyl formate
sopropylamine
Kodaflex txib
Lactofen
Lactonitrile
lambda-Cyhalothrin
Lead acetate
Linuron
Lithium carbonate
Lithium chloride
Malathion
Maleic anhydride
Maleic hydrazide
Malononitrile
Maneb
MCPA
m-Cresol
m-Dichloro benzene
Melamine
Mepiquat chloride
Mercaptoacetic acid
Merphos
Methacrylamide
Methacrylic acid
Methacrylonitrile
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Risk Specific Dose (RSD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Classification, EPA
Lowest Observed Effect Level (LOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lowest Observed Effect Level (LOEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Classification, EPA
Minimal Risk Level (MRL)
Cancer Studies, NTP
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Value
750
569
0.06
0.99
0.0000033
900
600
0.003
82.8
2.50
12
74.1
NTPMSR
4,763
25
5,000
10,400
NTPMSR
18
1.4
111
30
0.002
31
56
B
0.63
0.017
0.009
0.23
390
500
0.0001
0.005
0.0005
C
0.03
NTPMSR
0.03
114
0.00003
451
5
0.0001
Units
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg

mg/kg
mg/kg
mg/kg
mg/kg

mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day

mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 4
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 5
Toxicity Category 5
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
> 1B
>50M-100M
39,844,882
>500K-1M
165,485
> 1B
>50M-100M
> 1B
574,933
>10M-50M
43,517
>100M-500M
> 1B
>50M-100M
>1M-10M
>100M-500M
>100M-500M
>100M-500M
> 1B
>1M-10M
>100M-500M
>50M-100M
390,240
>10M-50M
321,987
>1M-10M
1.4
211,661
10K-500K
9.58
769,446
2,147,846
854,039
3,046,585
18.6
374,903
22.4
>100M-500M
182,976
>10M-50M
12
>50M-100M
>100M-500M
89,330
                                                                                     Page 30 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
10265926
67561
3268493
16752775
79209
96333
74839
598550
74931
80626
1634044
74895
12108133
93152
4553622
75796
9006422
51218452
171118095
152019733
21087649
101043372
64285069
143545908
2212671
7439987
1313275
105555
127195
108010
300765
91203
123864
97881
126307
7440020

7440031
139139
98953
1836755
55630
75525
872504
924425
55185
62759
924163
Substance Name
Phosphoramidothioic acid, O,S-dimethyl
ester
Methanol
Propanal, S-(methylthio)-
Ethanimidothioic acid, N-
](methylamino)carbonyl]oxy]-, methyl ester
Acetic acid, methyl ester
2-Propenoic acid, methyl ester
Methane, bromo-
Carbamic acid, methyl ester
Methanethiol
2-Propenoic acid, 2-methyl-, methyl ester
Propane, 2-methoxy-2-methyl-
Methanamine
Manganese, tricarbonyl[(1 ,2,3,4, 5-.eta. )-1-
methyl-2,4-cyclopentadien-1-yl]-
Benzene, 1 ,2-dimethoxy-4-(2-propenyl)-
Pentanedinitrile, 2-methyl-
Silane, trichloromethyl-
Metiram
Acetamide, 2-chloro-N-(2-ethyl-6-
methylphenyl)-N-(2-methoxy-1-methylethyl)-
Metolachlor ethanesulfonic acid
Metolachlor oxanilic acid
1 ,2,4-Triazin-5(4H)-one, 4-amino-6-(1 , 1-
dimethylethyl)-3-(methylthio)-
Microcystin LR
Anatoxin-a
Cylindrospermopsin
1 H-Azepine-1-carbothioic acid, hexahydro-,
S-ethyl ester
Molybdenum
Molybdenum oxide (MoO3)
Fhiourea, N,N'-diethyl-
Acetamide, N,N-dimethyl-
Ethanol, 2-(dimethylamino)-
Phosphoric acid, 1,2-dibromo-2,2-
dichloroethyl dimethyl ester
Naphthalene
Acetic acid, butyl ester
2-Propenoic acid, 2-methyl-, butyl ester
1,3-Propanediol, 2,2-dimethyl-
Nickel
Nickel compounds
Niobium
Glycine, N,N-bis(carboxymethyl)-
Benzene, nitro-
Benzene, 2,4-dichloro-1-(4-nitrophenoxy)-
1,2,3-Propanetriol, trinitrate
Methane, nitro-
2-Pyrrolidinone, 1-methyl-
2-Propenamide, N-(hydroxymethyl)-
Ethanamine, N-ethyl-N-nitroso-
Methanamine, N-methyl-N-nitroso-
1-Butanamine, N-butyl-N-nitroso-
Common Name
Methamidophos
Methanol
Methional
Methomyl
Methyl acetate
Methyl acrylate
Methyl bromide (Bromomethane)
Methyl carbamate
Methyl mercaptan
Methyl methacrylate
Methyl tert-butyl ether
Methylamine
Methylcyclopentadienyl manganese
tricarbonyl
Methyleugenol
Methylglutaronitrile
Methyltrichlorosilane
Metiram
Metolachlor
Metolachlor ethanesulfonic acid (ESA)
Metolachlor oxanilic acid (OA)
Metribuzin
Microcystin-LR
Anatoxin-a
Cylindrospermopsin
Molinate
Molybdenum
Molybdenum trioxide
N,N'-Diethylthiourea
N,N-Dimethylacetamide
N,N-Dimethylethanolamine
Naled
Naphthalene
n-Butyl acetate
N-Butyl methacrylate
Neopentyl glycol
Nickel
Nickel compounds
Niobium
Nitrilotriacetic acid
Nitrobenzene
Nitrofen
Nitroglycerin
Nitromethane
N-Methyl-2-pyrrolidone
N-Methylolacrylamide
N-Nitrosodiethylamine (NDEA)
N-nitrosodimethylamine (NDMA)
N-Nitroso-di-n-butylamine (NDBA)
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Tolerable Daily Intake (TDI)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Cancer Classification, EPA
Reference Dose (RfD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Cancer Studies, NTP
Maximum Recommended Daily Dose (MRDD)
Maximum Recommended Daily Dose (MRDD)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Cancer Classification, IARC
Cancer Classification, IARC
Cancer Classification, EPA
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Risk Specific Dose (RSD)
Reference Dose (RfD)
Risk Specific Dose (RSD)
Value
0.00005
3.1
1.52
0.1
3,705
0.03
0.001
NTPMSR
61
0.36
0.01
100
8
NTPMSR
10
800
0.03
C
Parent data
Parent data
0.62
0.000003
0.0005
0.00003
0.2
0.14
NTPMSR
NTPMSR
0.58
15
0.2
NTPMSR
14,000
3.57
100
1
1
A
NTPMSR
0.0005
NTPMSR
0.008
NTPMSR
120
NTPMSR
0.00000007
0.000008
0.000002
Units
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg

mg/kg
mg/kg
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day


mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
mg/kg-day




mg/kg-day

mg/kg-day

mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 1
Toxicity Category 5
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
FW/AW
FW/AW
FW/AW
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW
Release (Ibs/yr)
Value
967,698
201,697,278
>100M-500M
3
> 1B
206,487
43
>1M-10M
> 1B
3,657,567
23,000
>50M-100M
>1M-10M
10K-500K
>10M-50M
>100M-500M
1,388,363
77.6
Parent
Parent
6.61
Supple menta
Supple menta
Supplementa
200
4,733
2,102,324
10K-500K
>10M-50M
>50M-100M
606,781
906
>100M-500M
>10M-50M
>100M-500M
666
34,676,669
>1M-10M
30,679
100
25,300
55,979
>10M-50M
6,311,503
12,306
1,000
DBP
5
                                                                                     Page 31 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
621647
86306
10595956
684935
930552
27314132
103651
88733
95498
556672
20325400
528290
88722
95534
636215
19666309
75569
301122
42874033
10028156
72559
4685147
100005
106434
120718
100254
32534819
76017
115775
3296900
110623
14797730
52645531
335671
77098
101848
62384
57410
732116
7723140
88993
110894
156105
99990
Substance Name
1-Propanamine, N-nitroso-N-propyl-
Benzenamine, N-nitroso-N-phenyl-
Ethanamine, N-methyl-N-nitroso-
Urea, N-methyl-N-nitroso-
Pyrrolidine, 1-nitroso-
3(2H)-Pyridazinone, 4-chloro-5-
;methylamino)-2-[3-(trifluoromethyl)phenyl]-
Benzene, propyl-
Benzene, 1-chloro-2-nitro-
Benzene, 1-chloro-2-methyl-
Cyclotetrasiloxane, octamethyl-
1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethoxy-,
dihydrochloride
Benzene, 1,2-dinitro-
Benzene, 1-methyl-2-nitro-
Benzenamine, 2-methyl-
Benzenamine, 2-methyl-, hydrochloride
1 ,3,4-Oxadiazol-2(3H)-one, 3-[2,4-dichloro-5
(1-methylethoxy)phenyl]-5-(1,1-
dimethylethyl)-
Oxirane, methyl-
Phosphorothioic acid, S-[2-
(ethylsulfinyl)ethyl] O,O-dimethyl ester
Benzene, 2-chloro-1-(3-ethoxy-4-
nitrophenoxy)-4-(trifluoromethyl)-
Ozone
Benzene, 1 , 1 '-(dichloroethenylidene)bis[4-
chloro-
4,4'-Bipyridinium, 1,1'-dimethyl-
Benzene, 1-chloro-4-nitro-
Benzene, 1-chloro-4-methyl-
Benzenamine, 2-methoxy-5-methyl-
Benzene, 1,4-dinitro-
Benzene, 1,1'-oxybis-, pentabromo deriv.
Ethane, pentachloro-
1 ,3-Propanediol, 2,2-bis(hydroxymethyl)-
1 ,3-Propanediol, 2,2-bis(bromomethyl}-
Pentanal
Perchlorate
Cyclopropanecarboxylic acid, 3-(2,2-
dichloroethenyl)-2,2-dimethyl-, (3-
phenoxyphenyl)methyl ester
Octanoic acid, pentadecafluoro-
1 (3H)-lsobenzofuranone, 3,3-bis(4-
hydroxyphenyl)-
Benzene, 1,1'-oxybis-
Mercury, (acetato-. kappa. O)phenyl-
2,4-lmidazolidinedione, 5,5-diphenyl-
Phosphorodithioic acid, S-[(1,3-dihydro-1,3-
dioxo-2H-isoindol-2-yl)methyl]O,O-dimethyl
ester
Phosphorus
1 ,2-Benzenedicarboxylic acid
Piperidine
Benzenamine, 4-nitroso-N-phenyl-
Benzene, 1-methyl-4-nitro-
Common Name
N-Nitroso-di-n-propylamine (NDPA)
N-Nitrosodiphenylamine
N-Nitrosomethylethylamine (NMEA)
N-Nitroso-N-methylurea
N-nitrosopyrrolidine (NPYR)
Norflurazon
n-Propylbenzene
o-Chloronitrobenzene
o-Chlorotoluene
Octamethylcyclotetrasiloxane
o-Dianisidine dihydrochloride
o-Dinitrobenzene
o-Nitrotoluene
o-Toluidine
o-Toluidine hydrochloride
Oxadiazon
Oxirane, methyl-
Oxydemeton-methyl
Oxyfluorfen
Ozone
p,p'-DDE
Paraquat
p-Chloronitrobenzene
p-Chlorotoluene
p-Cresidine
p-Dinitrobenzene
Pentabromodiphenyl ethers
Pentachloroethane
Pentaerythritol
Pentaerythritol dibromide
Pentanal
Perchlorate
Permethrin
PFOA (Perfluorooctanoic acid)
Phenolphthalein
Phenyl ether
Phenylmercury acetate
Phenytoin
Phosmet
Phosphorus
Phthalic acid
Piperidine
p-Nitrosodiphenylamine
p-Nitrotoluene
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Risk Specific Dose (RSD)
Cancer Studies, NTP
Risk Specific Dose (RSD)
TD50
Risk Specific Dose (RSD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Cancer Studies, NTP
Cancer Classification, IARC
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Risk Specific Dose (RSD)
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
TD50
Risk Specific Dose (RSD)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
No Observed Effect Level (NOEL)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Reference Dose (RfD)
TD50
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Reference Dose (RfD)
Value
0.000001
NTPMSR
0.0000004
0.093
0.000005
0.04
2.5
0.001
0.02
1,540
NTPMSR
0.0001
NTPMSR
2A
NTPMSR
0.5
0.000042
10
0.3
1.9
0.000029
0.93
473
0.02
NTPMSR
0.0001
0.002
NTPMSR
100
NTPMSR
5.66
0.007
5
1.0
NTPMSR
2,450
0.00008
59.1
26
0.00002
0.56
22.4
NTPMSR
0.01
Units
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg

mg/kg-day



mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day

mg/kg-day

mg/kg
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg

mg/kg-day
Toxicity Screening
Category
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 4
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 2
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW
Release (Ibs/yr)
FW/AW
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Value
506
14
DBP
5
DBP
44.0
47
>10M-50M
52.4
>100M-500M
46
105,280
>10M-50M
10,774
22
28,822
433,536
154,565
706,799
715,830
0.062
6,899,701
>10M-50M
22.5
0
28,711
>10M-50M
865
>100M-500M
>1M-10M
>50M-100M
420
1,068,390
Supplementa
10K-500K
>50M-100M
>1M-10M
15,981
1,336,387
52,750
>1M-10M
>1M-10M
0
>10M-50M
                                                                                     Page 32 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
26062793
7440097
156434
41198087
1610180
107120
2312358
107197
123386
79094
1639607
57556
107982
108656
57018527
1698608
110861
2176627
14808607
91225
76578126
121824
793248
135988
74051802
7440213
7440235
26628228
532321
7647156
7775099
3926623
128041
25155300
62748
7681529
137428
1313822
13718268
50704
Substance Name
2-Propen-1-aminium, N,N-dimethyl-N-2-
propenyl-, chloride, homopolymer
Potassium
Benzenamine, 4-ethoxy-
Phosphorothioic acid, O-(4-bromo-2-
chlorophenyl) O-ethyl S-propyl ester
1 ,3,5-Triazine-2,4-diamine, 6-methoxy-N,N'-
bis(l-methylethyl)-
Propanenitrile
Sulfurous acid, 2-[4-(1,1-
dimethylethyl)phenoxy]cyclohexyl 2-propynyl
ester
2-Propyn-1-ol
Propanal
Propanoic acid
Benzeneethanol, .alpha.-[(1R)-2-
(dimethylamino)-1-methylethyl]-.alpha.-
phenyl-, propanoate (ester), hydrochloride,
(.alpha.S)-
1,2-Propanediol
2-Propanol, 1-methoxy-
2-Propanol, 1-methoxy-, acetate
2-Propanol, 1-(1,1-dimethylethoxy)-
3(2H)-Pyridazinone, 5-amino-4-chloro-2-
phenyl-
Pyridine
Pyridine, pentachloro-
Quartz (SiO2)
Quinoline
Quizalofop
1 ,3,5-Triazine, hexahydro-1 ,3, 5-trinitro-
1 ,4-Benzenediamine, N-(1 ,3-dimethylbutyl)-
N'-phenyl-
Benzene, (1-methylpropyl)-
2-Cyclohexen-1-one, 2-[1-
(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-
hydroxy-
Silicon
Sodium
Sodium azide (Na(N3))
Benzole acid, sodium salt
Sodium bromide (NaBr)
Chloric acid, sodium salt
Acetic acid, chloro-, sodium salt
Carbamodithioic acid, dimethyl-, sodium salt
Benzenesulfonic acid, dodecyl-, sodium salt
Acetic acid, fluoro-, sodium salt
Hypochlorous acid, sodium salt
Carbamodithioic acid, methyl-, monosodium
salt
Sodium sulfide (Na2S)
Vanadate (VO31-), sodium
D-Glucitol
Common Name
Poly(dimethyl diallyl ammonium chloride)
Potassium
p-Phenetidine
Profenofos
Prometon
Propanenitrile
Propargite
Propargyl alcohol
Propionaldehyde
Propionic acid
Propoxyphene hydrochloride
Propylene glycol
Propylene glycol 1-methyl ether
Propylene glycol monomethyl ether acetate
Propylene glycol mono-t-butyl ether
Pyrazon
Pyridine
Pyridine, pentachloro-
Quartz (SiO2)
Quinoline
Quizalofop
RDX (Hexahydro-1, 3,5-trinitro-1,3,5-triazine)
Santoflex 13
sec-Butyl benzene
Sethoxydim
Silicon
Sodium
Sodium azide
Sodium benzoate
Sodium bromide
Sodium chlorate
Sodium chloroacetate
Sodium dimethyldithiocarbamate
Sodium dodecylbenzenesulfonate
Sodium fluoroacetate
Sodium hypochlorite
Sodium methyldithiocarbamate
Sodium sulfide
Sodium vanadate
Sorbitol
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Cancer Classification, DSSTOX
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
No Observed Effect Level (NOEL)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Classification, IARC
Risk Specific Dose (RSD)
Reference Dose (RfD)
Risk Specific Dose (RSD)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Maximum Recommended Daily Dose (MRDD)
Value
290
0.94
0.24
0.05
0.015
35.8
0.02
20
LM
1,640
0.0013
5
0.7
300
NTPMSR
493
NTPMSR
435
1
0.0000033
Surrogate data
0.00009
6
4.42
8.9
3,160
9.4
0.25
1,600
0.13
1.4
95
300
438
0.00002
2.2
50
205
0.62
833
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg

mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg

mg/kg

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 4
Toxicity Category 2
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 5
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Value
>50M-100M
23,955
>1M-10M
881,702
40
>10M-50M
20
64,096
699,803
>100M-500M
10K-500K
> 1B
>100M-500M
>50M-100M
>1M-10M
118,553
1,302,842
>10M-50M
10K-500K
28,629
341,564
>1M-10M
>50M-100M
22
1,721,030
98,916
1,541,000
66,425
>50M-100M
>1M-10M
7,277,453
>10M-50M
129,318
>50M-100M
0
>10M-50M
60,154,489
>100M-500M
>1M-10M
>50M-100M
                                                                                     Page 33 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL

                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
131929607
57114
7440246
7782992
2699798
35400432
1934210
107534963
112410238
34014181
13494809
13071799
56070167
56070156
100210
75650
75912
75649
98066
78002
116143
109999
75570
75592
64028
25265774
79277671
2231574
59669260
23564058
Substance Name
1H-as-lndaceno[3,2-d]oxacyclododecin-7,15-
dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-.alpha.-
L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-
(dimethylamino)tetrahydro-6-methyl-2H-
py ra n-2-y I ]oxy ]-9-ethy I-
2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-
tetradecahydro-14-methyl-
Octadecanoic acid
Strontium
Sulfurous acid
Sulfuryl fluoride
Phosphorodithioic acid, O-ethyl O-[4-
(methylthio)phenyl] S-propyl ester
1 H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5
oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-
, trisodium salt
1H-1,2,4-Triazole-1-ethanol, .alpha.-[2-(4-
chlorophenyl)ethyl]-.alpha.-(1,1-
dimethylethyl)-
Benzoic acid, 3,5-dimethyl-, 1-(1,1-
dimethylethyl)-2-(4-ethylbenzoyl)hydrazide
Urea, N-[5-(1,1-dimethylethyl)-1,3,4-
thiadiazol-2-yl]-N,N'-dimethyl-
rellurium
Phosphorodithioic acid, S-[[(1,1-
dimethylethyl)thio]methyl] O,O-diethyl ester
Phosphorodithioic acid, S-[(1,1-
dimethylethyl)sulfonylmethyl]O,O-diethyl
ester
ferbufos-O-analogue sulfone
1 ,4-Benzenedicarboxylic acid
2-Propanol, 2-methyl-
Hydroperoxide, 1,1-dimethylethyl
2-Propanamine, 2-methyl-
Benzene, (1,1-dimethylethyl)-
Plumbane, tetraethyl-
Ethene, tetrafluoro-
Furan, tetrahydro-
Methanaminium, N,N,N-trimethyl-, chloride
Methanaminium, N,N,N-trimethyl-, hydroxide
Glycine, N,N'-1 ,2-ethanediylbis[N-
^carboxymethyl)-, tetrasodium salt
Propanoic acid, 2-methyl-, monoester with
2,2,4-trimethyl-1,3-pentanediol
2-Thiophenecarboxylic acid, 3-[[[[(4-methoxy
6-methyl-1 ,3,5-triazin-2-
yl)amino]carbonyl]amino]sulfonyl]-
Carbonothioic dihydrazide
Ethanimidothioicacid, N,N'-
thiobis[(methylimino)carbonyloxy]]bis-,
dimethyl ester
Carbamic acid, [1,2-
phenylenebis(iminocarbonothioyl)]bis-,
dimethyl ester
Common Name
Spinosyn A
Stearic acid
Strontium
Sulfurous acid
Sulfuryl fluoride
Sulprofos
Tartrazine
Tebuconazole
Tebufenozide
Tebuthiuron
Tellurium
Terbufos
Terbufos sulfone
Terbufos-O-analogue sulfone
Terephthalic acid
tert-Butanol
tert-Butyl hydroperoxide
tert-Butylamine
tert-Butylbenzene
Tetraethyl lead
Tetrafluoroethene
Tetrahydrofuran
Tetramethylammonium chloride
Tetramethylammonium hydroxide
Tetrasodium EDTA
Texanol
Thifensulfuron
Thiocarbazide
Thiodicarb
Thiophanate-methyl
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Acceptable Daily Intake (ADI)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lowest Observed Adverse Effect Level (LOAEL)
Reference Dose (RfD)
Cancer Studies, NTP
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
No Observed Effect Level (NOEL)
Value
0.02
1,490.5
190
0.5
100
0.6
0.014
0.03
0.02
7
20
0.000025
Parent data
Parent data
142.5
64.6
320
44
4.42
0.0000001
NTPMSR
NTPMSR
50
34
2,000
3,200
Surrogate data
6
0.03
8
Units
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg
mg/kg
mg/kg-day
mg/kg-day


mg/kg
mg/kg
mg/kg
mg/kg
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 3
Toxicity Category 5
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 1
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 4
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 3
Occurrence Data Element Used For Screening
Occurrence Data Element
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW-Max Value (ug/L)
FW/AW
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Value
117,572
>100M-500M
43,550
>1M-10M
142,720
308,713
>1M-10M
479,616
104,642
17.3
365.4
0.56
Surrogate
0.016
> 1B
1,548,617
>10M-50M
>10M-50M
77.5
>1M-10M
>50M-100M
1,430
>10M-50M
>10M-50M
>100M-500M
>100M-500M
105,375
>1M-10M
823,065
454,785
                                                                                     Page 34 of 35

-------
EPA-OGWDW
                                                                           CCL 3 Chemicals: Screening to a PCCL
                                                                                    Appendix 2
   EPA815-R-08-003
February 2008 DRAFT
CASRN
108985
137268
7440291
26471625
66841256
78488
1461229
102716
121448
112276
1582098
552307
512561
75503
77996
118967
101020
76879
126727
140089
115968
1120214
57136
51796
7440622
1314621
1929777
50471448
108054
75025
25013154
137304
Substance Name
Benzenethiol
fhioperoxydicarbonic diamide
([(H2N)C(S)]2S2), tetramethyl-
fhorium
Benzene, 1,3-diisocyanatomethyl-
Cyclopropanecarboxylic acid, 2,2-dimethyl-3-
(1,2,2,2-tetrabromoethyl)-, cyano(3-
phenoxyphenyl)methyl ester
Phosphorotrithioic acid, S,S,S-tributyl ester
Stannane, tributylchloro-
Ethanol, 2,2',2"-nitrilotris-
Ethanamine, N,N-diethyl-
Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-
Benzenamine, 2,6-dinitro-N,N-dipropyl-4-
;trifluoromethyl)-
5-lsobenzofurancarboxylic acid, 1 ,3-dihydro-
1 ,3-dioxo-
Phosphoric acid, trimethyl ester
Methanamine, N,N-dimethyl-
1 ,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-
Benzene, 2-methyl-1 ,3,5-trinitro-
Phosphorous acid, triphenyl ester
Stannane, hydroxytriphenyl-
1-Propanol, 2,3-dibromo-, phosphate (3:1)
Ethanol, 2-chloro-, phosphite (3:1)
Ethanol, 2-chloro-, phosphate (3:1)
Undecane
Urea
Carbamic acid, ethyl ester
Vanadium
Vanadium oxide (V2O5)
Carbamothioic acid, dipropyl-, S-propyl ester
2,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)
5-ethenyl-5-methyl-
Acetic acid ethenyl ester
Ethene, fluoro-
Benzene, ethenylmethyl-
Zinc, bis(dimethylcarbamodithioato-
.kappa.S,.kappa.S')-, (T-4)-
Common Name
Thiophenol
Thiram
Thorium-232
Toluene diisocyanate
Tralomethrin
Tributes
Tributyltin chloride
Triethanolamine
Triethylamine
Triethylene glycol
Trifluralin
Trimellitic anhydride
Trimethyl phosphate
Trimethylamine
Trimethylolpropane
Trinitrotoluene
Triphenyl phosphite
Triphenyltin hydroxide (TPTH)
Tris(2,3-dibromopropyl) phosphate
Tris(2-chloroethyl) phosphite
Tris(chloroethyl)phosphate
Undecane
Urea
Urethane
Vanadium
Vanadium pentoxide
Vernolate
Vinclozolin
Vinyl acetate
Vinyl fluoride
Vinyltoluene
Ziram
Health Effect/Toxicity Data Element Used For Screening
Health Effect Data Element
Reference Dose (RfD)
Reference Dose (RfD)
Cancer Classification, EPA
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
TD50
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
No Observed Effect Level (NOEL)
Lethal Dose 50 (LD50)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Reference Dose (RfD)
Lethal Dose 50 (LD50)
Acceptable Daily Intake (ADI)
Cancer Studies, NTP
Lethal Dose 50 (LD50)
Cancer Studies, NTP
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
TD50
Reference Dose (RfD)
Cancer Studies, NTP
Reference Dose (RfD)
Reference Dose (RfD)
TD50
Cancer Classification, IARC
Reference Dose (RfD)
TD50
Value
0.00001
0.005
A
NTPMSR
0.75
0.00003
0.03
100
1
3.6
0.75
1,900
NTPMSR
397
0.05
0.0005
444
0.0005
NTPMSR
100
NTPMSR
100
200
16.9
0.007
NTPMSR
0.001
0.025
341
2A
0.006
10.7
Units
mg/kg-day
mg/kg-day


mg/kg-day
mg/kg-day
mg/kg
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day
mg/kg

mg/kg
mg/kg-day
mg/kg-day
mg/kg
mg/kg-day

mg/kg

mg/kg-day
mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
mg/kg-day

mg/kg-day
mg/kg-day
Toxicity Screening
Category
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 1
Toxicity Category 2
Toxicity Category 1
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 4
Toxicity Category 1
Toxicity Category 3
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Toxicity Category 1
Toxicity Category 3
Toxicity Category 1
Toxicity Category 4
Toxicity Category 4
Toxicity Category 2
Toxicity Category 3
Toxicity Category 1
Toxicity Category 3
Toxicity Category 3
Toxicity Category 3
Toxicity Category 2
Toxicity Category 3
Toxicity Category 2
Occurrence Data Element Used For Screening
Occurrence Data Element
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
FW/AW-Median Value (ug/L)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
FW/AW-Max Value (ug/L)
Production Volume (Ibs/year)
Release (Ibs/yr)
Release (Ibs/yr)
Release (Ibs/yr)
Production Volume (Ibs/year)
Production Volume (Ibs/year)
Release (Ibs/yr)
Value
10K-500K
180,203
61.7
129,143
23,819
4,929,032
>1M-10M
>100M-500M
1,167,219
>100M-500M
1.74
>100M-500M
10K-500K
>50M-100M
>50M-100M
>1M-10M
>10M-50M
662,418
500
>10M-50M
0.20
>100M-500M
> 1B
96,050
70.4
>1M-10M
182,187
122,226
3,068,589
>1M-10M
>10M-50M
1,996,914
                                                                                     Page 35 of 35

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