United States Environmental Protection Agency Contaminant Candidate List 3 Microbes: Screening to the PCCL Office of Water (4607M) EPA 815-R-08-006 February 2008 - Draft www.epa.gov/safewater ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Contents Abbreviations and Acronyms 2 1.0 Background and Scope 3 2.0 Recommendations for Screening a Universe of Drinking Water Contaminants to Produce a PCCL 3 3.0 Definition of Screening Criteria and Rationale for Their Application 4 3.1 Application of Screening Criteria to the Microbial CCL Universe 8 4.0 Additional Screening Criteria Considered 9 4.1 Organism Covered by Existing Regulations 9 5.0 Data Sources Used for Screening the Microbial CCL 3 Universe 11 6.0 Summary 12 7.0 References 13 Attachment A: Screening to the PCCL Al Exhibits Exhibit 1. Summary of Screening of Microbial CCL 3 Universe 8 Abbreviations and Acronyms AWWA - American Water Works Association AWWARF - American Water Works Association Research Foundation CCL - Contaminant Candidate List CCL 1 - EPA's First Contaminant Candidate List CCL 2 - EPA's Second Contaminant Candidate List CCL 3 - EPA's Third Contaminant Candidate List MCLG - Maximum Contaminant Level Goal NDWAC - National Drinking Water Advisory Council NRC - National Research Council NPDWR - National Primary Drinking Water Regulation SDWA - Safe Drinking Water Act ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Contaminant Candidate List 3 Microbes: Screening to the PCCL 1.0 Background and Scope The document titled, CCL 3 Microbes: Identifying the Universe (USEPA, 2007) provides a summary of the statutory and regulatory background leading to development of a microbial Contaminant Candidate List (CCL) and the subsequent activities to develop a microbial CCL 3 universe as the initial step in a transparent and scientifically sound Contaminant Candidate List Classification Process (CCLCP). This document summarizes criteria that the Environmental Protection Agency (EPA) uses for screening a universe of microbiological contaminants to identify those contaminants in the microbial CCL 3 universe to be placed on a Preliminary Contaminant Candidate List (PCCL). These criteria were developed in part following the recommendations of the National Research Council (NRC), the National Drinking Water Advisory Council (NDWAC) workgroup on the CCL process. The recommended screening process was reviewed by a panel of external experts, and the screening process described herein was derived from the subsequent deliberations of the EPA microbiology workgroup based upon the expert panel report. 2.0 Recommendations for Screening a Universe of Drinking Water Contaminants to Produce a PCCL The NRC recommendations for a CCLCP are described in, Classifying Drinking Water Contaminants for Regulatory Consideration (NRC, 2001). The NRC workgroup identified a hierarchical framework for evaluating the potential occurrence of microbial contaminants in drinking water. This approach suggested that EPA could obtain data on microbial contaminant occurrence from existing occurrence databases and lists. Microbes with demonstrated or potential occurrence in drinking water, and microbes with demonstrated or potential ability to cause adverse health effects from drinking water exposure were recommended for inclusion in a PCCL. The NRC workgroup report did not contain specific recommendations for selection and screening of microbial contaminants to a PCCL, and because occurrence data are not readily available to support the screening process envisioned by the NRC workgroup, the Agency requested further study of these issues by a workgroup convened by the NDWAC. NDWAC recommended selecting microbial contaminants for a PCCL based upon an assessment of occurrence attributes and health effects attributes relating to the plausibility of pathogen presence, survival, and transport through drinking water resulting in disease manifestations from drinking water exposure. These recommendations are described further in, National Drinking Water Advisory Council Report on the CCL Classification Process (NDWAC, 2004). The microbial CCL 3 universe was defined by the NDWAC workgroup as microbes that are known to cause disease in humans. A literature review identified a list of 1,415 known human pathogens including bacterial, viral, protozoan, helminth, and fungal pathogens (Taylor et ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT al., 2001). The Taylor list was recommended as the basis of the microbial CCL 3 universe. EPA requested nominations from the scientific community for additions to the microbial CCL 3 universe, and four microbes were added to the list through the nomination process (USEPA, 2006). EPA also added 6 fungi that did not appear on the list of Taylor et al. (2001) but were identified in drinking water distribution systems. EPA also added one virus that was identified as an emerging pathogen of potential interest, thus bringing the total number of microbes in the CCL 3 universe to 1,425 pathogens. Selection of microbes from the CCL 3 Universe for placement on the PCCL is based upon screening criteria that assess the potential of water-related transmission (occurrence) and the plausibility of causing waterborne disease by ingestion, inhalation, or dermal contact (health effects). NDWAC recommended ten screening criteria for initial screening of pathogens in the microbial CCL universe for placement on a PCCL. NDWAC also suggested that supplementing these screening criteria may be necessary to insure that microbes on a PCCL represent only those pathogens whose occurrence and health effects are attributable to drinking water. The principles supporting supplemental screening criteria include: • biological characteristics related to occurrence and survival • taxonomic consolidations of genera or species by designating a representative genus/species, i.e. allowing the designated type species of a pathogen to represent the genus for screening purposes • reliance upon epidemiological data to determine potential of adverse health effects attributable to a drinking water source The NDWAC workgroup evaluated the possibility of using virulence factor activity relationships (VFARs) as a means of identifying potential waterborne pathogens. The workgroup concluded that additional studies were necessary before VFARs could be used to screen microbes to a PCCL (NDWAC 2004). EPA restricted the PCCL to pathogens that are known to be associated with source water, and recreational water only if the water is also drinking water (e.g., swimming pools) are considered as candidates for the PCCL. Screening criteria are used to exclude those pathogens whose biological properties are incompatible with water transmission by ingestion, inhalation or dermal contact, and those pathogens that are typically introduced from sources other than drinking water. 3.0 Definition of Screening Criteria and Rationale for Their Application Screening criteria were developed based upon epidemiology, geographical distribution, and biological properties in the host and in the environment. Screening criteria recommended by NDWAC, as amended by the EPA microbiology workgroup following external peer review, are listed below. Only one criterion is needed to screen out a pathogen. All pathogens that are not excluded under any screening criteria are moved to the PCCL. However, any pathogen documented to cause disease transmitted through drinking water, regardless of the following screening criteria, is considered for the PCCL. ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Criterion 1: Anaerobes (microorganisms that cannot survive in oxygenated environments) Anaerobes are microorganisms that cannot survive in the presence of oxygen (Murray et al., 2007). Because of oxygen toxicity, they are unable to survive in the ambient water environment, and they pose negligible threat to human health from drinking water exposure. Examples of anaerobes that are screened out based on this screening criterion include members of the bacterial genera Actinomyces, Bacteroides, Clostridium, Eubacterium, Fusobacterium, and Prevotella, among others (Murray et al., 2007). Criterion 2: Fastidious or obligate intracellular pathogens (environmental survival in water implausible) Fastidious or obligate intracellular pathogens rely upon their host to provide essential nutrients and growth factors that are not present in the environment, hence these pathogens cannot survive outside their hosts. Many fastidious or obligate intracellular pathogens have a narrow temperature and pH range as a result of host adaptation, and they cannot survive the wide range of temperatures and pH common in the ambient environment. Examples of fastidious or obligate intracellular pathogens that are screened out include members of the genera Chlamydophila, Mycoplasma, and Orientia (Murray et al., 2007). This criterion is applied only to bacteria, since all viruses are obligate intracellular pathogens (Knipe and Howley, 2007). Criterion 3: Pathogens exclusively transmitted by direct or indirect contact with blood or body fluids (including sexually transmitted diseases) Some pathogens are transmitted by direct or indirect contact with blood or body fluids, where fecal-oral transmission or transmission by aerosolized water is not observed (Mandel et al. 2005). Pathogens causing bloodborne diseases and sexually transmitted diseases are highly host adapted, fastidious, and are usually not present in feces. They do not survive under environmental conditions, and they are not transmitted by the fecal-oral route, either by direct contact with feces or indirect contact with contaminated drinking water. Examples of pathogens transmitted by blood or body fluids include the etiologic agents of gonorrhea and syphilis, Chlamydia, herpes virus, human immunodeficiency virus, and hepatitis virus B, C, D and G (Murray et al., 2007). Criterion 4: Pathogens transmitted by vectors Vectors include arthropods and rodents (Acha and Szyfres, 2001). Pathogens transmitted by vectors depend upon either insect or other bites, or close contact with rodents, and these pathogens are not transmitted by contact with drinking water. Mosquitoes, ticks, and fleas are the most common vectors of arthropod-borne diseases (Krauss, et al., 2003). Examples of vector- borne pathogens include bacteria, viruses, protozoa, and helminths. The genera Babesia, ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Borrelia, Brugia, Dirofilaria, Ehrlichia, Leishmania, Plasmodium, Trypanosoma, Rickettsia, and all arthropod-borne viruses were not moved to the PCCL (Murray et al., 2007). Criterion 5: Microflora indigenous to the gastrointestinal tract, skin and mucous membranes The human body is colonized with a rich and commensal microflora (Finegold et al., 1983; Drasar and Barrrow, 1985; Isenberg and D'Amato, 1995). Some microbes that colonize the human body are transitory, while others are part of the continuing normal flora of the body. Microbes comprising normal flora have a characteristic ecological niche, but sometimes conditions permit their access to areas of the body where they may exhibit pathogenic potential resulting in infection and disease. Infections with normally innocuous microbes are called opportunistic infections, because of their ability to exploit host conditions that may periodically predispose them to disease. Because exposure to normal flora microbes is continuous throughout life, and because the populations of normal flora microbes exceed the number of these microbes present in drinking water by many orders of magnitude, drinking water represents an improbable source of infection and disease. Examples of normal flora include members of the genera Capnocytophaga, Corynebacterium, Staphylococcus, Streptococcus, and several yeasts (Murray et al., 2007). Criterion 6: Pathogens transmitted solely by respiratory secretions Pathogens causing respiratory disease are typically transmitted by direct contact with respiratory secretions, either by inhalation of aerosols, by direct person-to-person contact, or by contact with fomites. Drinking water is an unlikely mode of transmission because the number of pathogens in respiratory secretions and the continuity of exposure to respiratory secretions far exceed exposure through drinking water (Bennet and Brachman, 1998). Examples of pathogens transmitted by respiratory secretions include the etiologic agents of tuberculosis, diphtheria, whooping cough, measles, rubella, and influenza (Knipe and Howley, 2007; Murray et al., 2007; Mandel et al., 2005). Criterion 7: Pathogens whose life cycle is incompatible with drinking water transmission Some pathogens such as helminths, require intermediate hosts to complete their life cycles, and incidental infection of humans results in an interruption of their life cycle with subsequent death of the pathogen (Acha and Szyfres, 2001). Some pathogens are adapted to a single route of transmission such as rabies virus, which is transmitted by animal bites. Some pathogens are specifically adapted to survive in a unique ecological niche, and they cannot withstand any alteration of conditions to which they are adapted. For example, rabies virus, Dientamoebafragilis, Enterobius vermicularis, and many helminths remain in the microbial CCL 3 universe and are not considered for the PCCL based on this criterion (Murray et al., 2007; Ashford and Crewe, 2003). ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Criterion 8: Pathogens where drinking water-related transmission is not implicated Some pathogens cause such rare occurrences of disease that only a few cases have been reported in medical literature, and these rare occurrences of disease present limited opportunity to protect public health from drinking water exposure (Acha and Szyfres, 2001; Knipe and Howley, 2007; Murray et al., 2007; Mandel et al., 2005). Some pathogens are associated with direct transmission from animals to humans, or other transmission routes that do not involve drinking water (Acha and Szyfres, 2001; Krauss et al, 2003; Howard, 2003). Examples of pathogens that remain in the microbial CCL 3 universe after application of this criterion are Leptospira, Listeria, Nosema, and the etiologic agents of several zoonotic virus infections (Knipe and Howley, 2007; Murray et al., 2007). Criterion 9 Natural habitat is in the environment without epidemiological evidence of drinking water-related disease The environment is teeming with microorganisms, at varying concentrations, and humans are in constant contact with these microorganisms throughout their lives (Bennett and Brachman, 1998; Isenberg and D'Amato, 1995). Microorganisms naturally present in the environment are not considered a threat to public health as a result of drinking water exposure unless epidemiological evidence demonstrates a potential for water-related disease. Thus, outbreaks occurring in nosocomial settings or attributable to recreational water resulting from post-delivery contamination of drinking water are not sufficient to place a microorganism on the PCCL unless the drinking water system was shown to be contaminated (Wenzel, 2003). Acinetobacter, Gordonia, Nocardia, Pseudomonas, and most fungi are excluded from the PCCL based on this criterion (Murray et al., 2007; Howard, 2003). Criterion 10 Pathogens not endemic to North America Some pathogens have an exclusive geographical distribution, and they are not naturally present in North America (Ashford and Crewe, 2003; Murray et al., 2007; Palmer et al., 1998). Only pathogens endemic to North America have the potential to contaminate drinking water in the U.S. Several helminths such as most Diphyllobothrium, and Paragonimus species and several viruses such as the hemorrhagic fever viruses and poxviruses would remain in the microbial CCL universe after application of this criterion. Criterion 11 A genus and species or serotype may be chosen to represent a group of closely related organisms EPA has chosen a few pathogens to represent a group based on all serotypes within a group sharing essential biological properties in common with the group. Designation of a representative group provides adequate protection of public health under the CCLCP (Murray et ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT al., 2007). Pathogens that represent other pathogens in their group are the following: Arcobacter butzleri, Campylobacter jejuni, Helicobacter pylori, Legionella pneumophila, Salmonella enterica, Shigella sonnet, y4denovirus, Astrovirus, Enterovirus, Microsporidia, and Entamoeba histolytica. Criterion 12 Current taxonomy does not support the classification listed by Taylor et al. (2001). Microbial taxonomy and nomenclature is a dynamic science, and taxonomic classifications are constantly changing. Original taxonomic classifications were based upon the phenotypic characteristics of microorganisms, but these classifications are being revised as genotypic information becomes available. New genera are formed, sometimes prematurely, based upon partial genomic data, and taxonomists do not always agree with proposed changes. Under this criterion, the genera Fluoribacter and Tatlockia are combined with the genus Legionella for screening purposes (Murray et al., 2007). 3.1 Application of Screening Criteria to the Microbial CCL Universe Bacteria, viruses, protozoa, helminths, and fungi in the CCL 3 Universe are shown respectively in the tables of Attachment A, and CCL 3 Microbes: Indentifying the Universe. Each table identifies the pathogens in each category and indicates which screening criteria were applied to remove pathogens from further consideration in the CCL Process. Those pathogens not excluded by at least 1 of the 10 screening criteria or consolidated under criteria 11 or 12 pass on to the PCCL. The summary data from the screening is shown in Exhibit 1. Exhibit 1. Summary of Screening Microbial CCL 3 Universe Pathogen Class Bacteria Viruses Protozoa1 Helminths Fungi Total Total 540 219 66 287 313 1,425 Screening Criteria 1 125 0 0 0 0 125 2 14 0 0 0 0 14 3 10 26 1 0 0 37 4 37 99 29 25 0 190 5 117 0 3 0 13 133 6 7 17 0 0 1 25 7 0 1 4 107 0 112 8 29 16 7 0 0 52 9 154 0 7 0 309 470 10 2 45 0 155 0 202 11 28 8 6 0 0 42 12 5 0 0 0 0 5 On PCCL 12 7 7 0 3 29 ^ryptosporidium and Giardia are considered to be regulated by LT2. They were not screened and were not considered for CCL3. Based upon this screening exercise conducted on 1,425 pathogens in the microbial CCL universe 1,394 pathogens were excluded from consideration while 29 pathogens passed to the PCCL. The specific screening decisions and references are presented in Attachment A. ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT 4.0 Additional Screening Criteria Considered As the CCL3 process developed, EPA considered screening criteria in addition to the twelve described above. While each of these additional criteria had merit, they were not consistent with the ultimate goal of the CCL3. The goal of the CCL is to identify potential contaminants that may require regulation. The basis for regulating specific contaminants is: • Occurrence at a level and frequency that presents a potential public health risk, and • The feasibility and opportunity for achieving meaningful reduction of exposure from such contaminants. Listing contaminants on the CCL identifies the need for collecting additional information to inform the basis for potential regulations, and if that threshold of information is met, to support new regulation or revisions to existing regulations to control or improve control for such contaminants. If contaminants are not listed on a CCL (e.g., CCL 3), EPA may include those contaminants as occurrence and health effects information becomes available in a future listing. The following subsections present additional screening criteria that EPA considered but elected not to use at this time. 4.1 Organism Covered by Existing Regulations 4.1.1 Organisms Covered by Fecal Indicator Monitoring EPA considered a screening criterion based upon contaminants that might be controlled through drinking water monitoring requirements under current drinking water regulations. Many of the bacteria in the CCL Universe, including the Enterobacteriaceae and members of the genera Campylobacter and Vibrio, are associated with fecal contamination and as such their presence could be signaled by the monitoring requirements under the Total Coliform Rule (TCR). Under the TCR, EPA chose to require monitoring for Escherichia coli (and total coliforms) in finished drinking water because it provides a broad indication of the potential presence of fecal pathogens in drinking water, though more so for bacteria than for viruses and protozoa. EPA chose not to exclude common enteric bacterial pathogens from the PCCL even though they may be indicated by the TCR. Numerous waterborne disease outbreaks have occurred in systems that were in compliance with maximum contaminant limit (MCL) drinking water monitoring requirements under the TCR. EPA recognizes that monitoring under the TCR (i.e., monitoring for total coliforms andE. coli or fecal coliforms when total coliforms are present, (Oldstadt, et al., 2007)) may not always be protective against bacterial fecal contamination. The frequency of total coliform monitoring under the TCR is limited, especially for smaller systems, thus transitory fecal contamination could go undetected. EPA believes that enteric pathogens should be included for further regulatory consideration in the CCL because monitoring under the TCR may be too limited to protect against specific types of bacterial fecal contamination. ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT 4.1.2 Organisms Covered by Treatment Technique According to the Safe Drinking Water Act (SDWA), EPA must select contaminants that "at the time of publication, are not subject to any proposed or promulgated national primary drinking water regulation..." In promulgating regulations for drinking water contaminants, EPA can set either a legal limit (MCL) and require monitoring for the contaminant in drinking water or EPA can establish a treatment technique requirement. The Surface Water Treatment Rule (SWTR) included maximum contaminant level goals (MCLGs), for Legionella, Giardia, and viruses of zero because any amount of exposure to these contaminants represents some public health risk. Since measuring disease-causing microbes in drinking water is not considered to be feasible, EPA established a treatment technique requirement for these contaminants. The purpose of subsequent treatment technique requirements (Interim Enhanced Surface Water Treatment Rule, Long Term Surface Water Treatment Rule 1 and Long Term Surface Water Treatment Rule 2), which included an MCLG of zero for Cryptosporidium, is to reduce disease incidence associated with Cryptosporidium and other pathogenic microorganisms in drinking water. Therefore, they are excluded from the PCCL. Cryptosporidium and Giardia have a substantial amount of associated research regarding health effects and sensitivity to various treatment control measures. The Ground Water Rule (GWR) sets treatment technique requirements to control for viruses (and pathogenic bacteria), because it was not feasible to directly monitor for viruses (or pathogenic bacteria) in drinking water. Under the GWR, if systems detect total coliforms in the distribution system, they are required to monitor for a fecal indicator (E. coli, coliphage, or enterococci) in the source water. If fecal contamination is found in the source water, the system must take remedial action to address contamination. EPA did not exclude specific viruses and Legionella from the PCCL even though they have broad category MCLGs and treatment technique requirements. Viruses and Legionella include a wide range of taxa for which EPA has much less information concerning health effects and treatment information. The available information for different viral taxa (e.g., dose response and treatment data) was very limited when setting the treatment technique requirements for surface water and ground water systems. Also, different viral taxa have been implicated in various waterborne disease outbreaks in distribution systems. EPA did not have viral dose response or treatment data at the time of promulgating the treatment technique requirements. Legionella has been recognized as occurring in public water systems and has been recently implicated in numerous waterborne disease outbreaks (WBDOs) in distribution. 10 ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT 5.0 Data Sources Used for Screening the Microbial CCL 3 Universe Various data sources were used to gather the information for this screening process. The data sources used were evaluated by EPA to ensure they were authoritative and appropriate. For microbes, the universe list was defined as all known human pathogens using the compilation of Taylor et al. (2001) as a practical starting point. This list was supplemented by adding fungi isolated from drinking water distribution systems that did not appear on the Taylor list, and by nominations from the scientific community, as described earlier in this report (see also CCL 3 Microbes: Identifying the Universe, EPA, 2007). For microbes, the data sources were sought to develop the information needed for screening (and later scoring) for the pathogens in the defined CCL 3 Microbial Universe. The hierarchy of text-based resource materials begins with recently compiled authoritative reference books such as The Manual of Clinical Microbiology, 9th Edition, and Field's Virology, 5th Edition, both published in 2007. Both of these two-volume reference books have become established as the leading authoritative reference sources in their respective fields, both references have evolved through multiple editions, and both publications are considered reference standards to the scientific community for their scope and depth of coverage. They are edited by world-recognized authorities, and chapters are written by an international team of subject experts. The parasites of Homo sapiens, second edition, is a comprehensive source for information on the helminthes. These and other compiled sources listed in the reference list below were used to provide the information for screening the pathogens in the microbial CCL 3 Universe. Primary publications were used to supplement compiled sources as necessary to support screening decisions for the fungi that were added to the CCL 3 Microbial Universe. However, some pathogens in the CCL 3 Microbial Universe were unusual or obscure, and were not covered in the compiled or primary sources. They required alternative sources, and these pathogens were searched for individually, using Web searches of authoritative on-line sources. Web references were used to find information for screening rarely encountered viruses, protozoa, and fungi, primarily for information related to Criterion 9, "natural habitat in the environment," or Criterion 10, "pathogen not endemic to North America". Selected Web references were evaluated to ensure that the site sponsors possessed the expertise to authoritatively address the issues of habitat and geographical distribution of the pathogen in question, and that the information was presented objectively and reviewed by members of the scientific community. Emphasis was placed upon Web sites sponsored and supported by government agencies or academic institutions, with evidence of peer review, such as an editorial board and/or expert contributors and reviewers. Attachment A, The CCL 3 Microbial Universe List, tabulates the screening decisions for the CCL 3 Microbial Universe, and shows the screening reference used to support the decision. Page ranges cited and Web addresses/links provided are as narrow and specific as they can be, to identify the information related to the screening criterion used. Many pathogens could be screened by several criteria, however only one criterion is noted in the tabulation. Understanding 11 ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT the complete context and rationale for a screening decision often requires a review of the complete chapter from which the specified page range was taken. 6.0 Summary Properly designed screening criteria will restrict the microbial PCCL to human pathogens that may cause drinking water-related diseases from ingestion, inhalation, or dermal contact. Pathogens failing to meet these criteria will remain in the microbial universe until epidemiological surveillance data or nomination processes support their reevaluation. Ten screening criteria and two consolidation criteria have been proposed for selection of pathogens in the microbial CCL3 universe to a PCCL. Application of these twelve criteria to the microbial CCL3 universe results in a PCCL containing 29 pathogens 12 ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT 7.0 References Acha, P. N. and B. Szyfres (ed.). 2001. Zoonoses and Communicable Diseases Common to Man and Animals. Volume I, Bacterioses and Mycoses. Scientific and Technical Publication No. 580. Pan American Health Organization. Washington D.C., USA. Ashford, R. W. and W. Crewe. 2003. The parasites of Homo sapiens: An annotated checklist of the protozoa, helminths and arthropods for which we are home. Taylor and Francis, London, UK. Bennett, J. V. And P. S. Brachman (ed.). 1998. Hospital infections. Lippincott-Raven, Philadelphia, PA. Doggett, M. S. 2000. Characterization of fungal biofilms within a municipal water distribution systems. Applied and Environmental Microbiology 66:1249-1251. Drasar, B. S., and P. A. Barrow. 1985. Intestinal Microbiology, Vol. 10. Van Nostrand Reinhold, Berkshire. Finegold, S. M., S. V. L., and G. E. Mathisen. 1983. Normal Indigenous Intestinal Flora, p. 3-31. In D. J. Hentges (ed.), Human Intestinal Microflora in Health and Disease. Academic Press, New York. Howard, D. H. (ed.) 2003. Pathogenic fungi in humans and animals, 2nd Edition. Marcel Dekker, Inc., New York, NY. Isenberg, H. D. and R. F. D'Amato. 1995. Indigenous and Pathogenic Microorganisms of Humans. In Murray, P. R., E. J. Baron, M. A. Pfaller, F. C. Tenover, and R. H. Yolken, ed. Manual of Clinical Microbiology, 6th ed. ASM Press, Washington, DC. Knipe, D. M. and P. M. Howley (ed.). 2007. Fields Virology, 5th Edition, Wolters-Kluwer Lippincott Williams & Williams, Philadelphia. Kolafova, Libuse, 2007. Schistosomes causing cercarial dermatitis: a mini-review of current trends in systematics and of host specificity and pathogenicity. Folia Parasitologica 54: 81-87, 2007. Krauss, H., A. Weber, M. Appel, B. Enders, H. D. Isenberg, H. G. Schiefer, W. Slenczka, A. von Graevenitz, and H. Zahner. 2003. Zoonoses, Infectious Diseases Transmissible from Animals to Humans, 3rd. Edition. ASM Press, Washington, DC. Mandel, G. L., J. E. Bennett, and R. Dolin (ed.). 2005. Douglas and Bennett's Principles and Practice of Infectious Diseases, 6th Edition, Elsevier, Philadelphia. 13 ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Murray, P. R., E. J. Baron, J. H. Jorgensen, M. L. Landry, and M. A. Pfaller (ed.). 2007. Manual of Clinical Microbiology, 9th Edition, ASM Press, Washington, DC. National Research Council (NRC). 2001. Classifying Drinking Water Contaminants for Regulatory Consideration. National Academy Press, Washington DC. National Drinking Water Advisory Council (NDWAC). 2004. National Drinking Water Advisory Council Report on the CCL Classification Process to the U. S. Environmental Protection Agency, May 19, 2004 Olstadt, J., J. Schauer, J. Standridge and S. Kluender. 2007. A comparison often USEPA approved total coliform/E. coli tests. Journal of Water and Health, 05.2:267 - 282. Palmer, S. R., Lord Soulsby, and D. I. H. Simpson (ed.). 1998. Zoonoses: biology, clinical practice, and public health control. Oxford University Press, Oxford, UK. Patterson, Thomas F. 2005. Advances and challenges in management of invasive Mycoses. Lancet 2005; 366: 1013-25. Rosenzweig, W. H. Minnigh and W. Pipes. 1986. Fungi in Potable Water Systems. Research and Technology; AWWA:53. January 1986. Taylor, L. H., S. M. Latham, and M. E. Woolhouse. 2001. Risk factors for human disease emergence Philosophical Transactions of the Royal Society of London B. Vol. 356, pp. 983-989 (See electronic Appendix A, No. 1411, pp. 1-9). United States Environmental Protection Agency (USEPA). 2006. Request for nominations of drinking water contaminants for the contaminant candidate list. Federal Register 71(199):60704- 60708. United States Environmental Protection Service (USEPA). 2007. Contaminant Candidate List 3 Microbes: Identifying the Universe. Wenzel, R. P. (ed.). 2003. Prevention and control of nosocomial infections. Lippincott Williams & Wilkins, Philadelphia, PA. West, P. R. 1986. Isolation rates and characterization of fungi in drinking water distribution systems. Proceedings of the Water Quality Technology Conference, American Water Works Association, Denver, CO. 14 ------- EPA-OGWDW CCL 3 Microbes: EPA 815-R-08-006 Screening to the PCCL February 2008 - DRAFT Attachment A: Screening to the PCCL Al ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Abiotrophia defective Achromobacter piechaudii Achromobacter xylosoxidans Acidaminococcus fermentans Acinetobacter baumannii Acinetobacter calcoaceticus Acinetobacter haemolyticus Acinetobacter johnsonii Acinetobacter junii Acinetobacter Iwoffii Acinetobacter radioresistens Actinobacillus equuli Actinobacillus hominis Actinobacillus lignieresii Actinobacillus pleuropneumoniae Actinobacillus suis Actinobacillus ureae Actinomyces georgiae Actinomyces gerencseriae Actinomyces israelii Actinomyces meyeri Actinomyces naeslundii Actinomyces neuii Actinomyces odontolyticus Actinomyces radingae Actinomyces turicensis Aerococcus viridans Aeromonas caviae Aeromonas hydrophila Aeromonas sobria Aeromonas veronii Alcaligenes odorans Amycolatopsis orientalis Arcanobacterium bernardiae Arcanobacterium heamolyticum Arcanobacterium pyogenes Arcobacter butzleri Arcobacter cryaerophilus Bacillus anthracis Bacillus cereus Bacillus circulans Bacillus coagulans Bacillus licheniformis Bacillus mycoides Bacillus pumilus Bacillus sphaericus Screening Criteria Used for Exclusion 1 X X X X X X X X X X 2 3 X X X X X 4 5 X X X X X X 6 7 8 9 X X X X X X X X X X X X X X X X X X X X X X 10 11 X 12 PCCL Aeromonas hydrophila Arcobacter butzleri Page Reference MCM-9, p. 445 MCM-9, p. 777 MCM-9, p. 777 MCM-9, p. 862-863 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 771-773 MCM-9, p. 621-623 MCM-9, p. 621-623 MCM-9, p. 621-623 MCM-9, p. 621-623 MCM-9, p. 621-623 MCM-9, p. 621-623 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 445 MCM-9, p. 716-717 MCM-9, p. 716-717 MCM-9, p. 716-717 MCM-9, p. 777 MCM-9, p. 520 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 935 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 455-456 A2 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Bacillus subtilis Bacillus thuringiensis Bacteroides caccae Bacteroides distasonis Bacteroides eggerthii Bacteroides forsythus Bacteroides fragilis Bacteroides galacturonicus Bacteroides merdae Bacteroides ovatus Bacteroides pectinophilus Bacteroides splanchnicus Bacteroides stercoris Bacteroides thetaiotaomicron Bacteroides uniformis Bacteroides ureolyticus Bacteroides vulgatus Bartonella bacilliformis Bartonella elizabethae Bartonella henselae Bartonella quintana Bergeyella zoohelcum Bifidobacterium dentium Bilophila wadsworthia Bordetella avium Bordetella bronchiseptica Bordetella parapertussis Bordetella pertussis Borrelia brasiliensis Borrelia burgdorferi Borrelia caucasica Borrelia crocidurae Borrelia duttonii Borrelia hermsii Borrelia hispanica Borrelia latyschewii Borrelia mazzottii Borrelia parkeri Borrelia persica Borrelia recurrentis Borrelia turicatae Borrelia venezuelensis Brevibacillus brevis Brevundimonas diminuta Brevundimonas vesicularis Brucella melitensis Screening Criteria Used for Exclusion 1 X X X X X X X X X X X X X X X X X 2 X 3 4 X X X X X X X X X X X X X X X X X X 5 X 6 X X X X 7 8 9 X X X X X 10 11 12 PCCL Page Reference MCM-9, p. 455-456 MCM-9, p. 455-456 MCM-9, p. 91 1 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 850-851 MCM-9, p. 850-851 MCM-9, p. 850-851 MCM-9, p. 850-851 MCM-9, p. 793 MCM-9, p. 872-873 MCM-9, p. 911 MCM-9, p. 803 MCM-9, p. 803 MCM-9, p. 803 MCM-9, p. 803 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 972-973 MCM-9, p. 455, 458 MCM-9, p. 750-751 MCM-9, p. 750-751 MCM-9, p. 825 A3 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Burkholderia cepacia Burkholderia mallei Burkholderia pseudomallei Campylobacter coli Campylobacter concisus Campylobacter curvus Campylobacter fetus Campylobacter gracilis Campylobacter hyointestinalis Campylobacter lari Campylobacter rectus Campylobacter sputorum Campylobacter upsaliensis Capnocytophaga canimorsus Capnocytophaga cynodegmi Capnocytophaga gingivalis Capnocytophaga ochracea Capnocytophaga sputigena Cardiobacterium hominis Cedecea davisae Cedecea lapagei Cedecea neteri Cellulomonas cellulans Cellulomonas turbata Centipeda periodontii Chlamydia trachomatis Chlamydophila pneumoniae Chlamydophila psittaci Chromobacterium violaceum Chryseobacterium balustinum Chryseobacterium meningosepticum Citrobacter amalonaticus Citrobacter braakii Citrobacter farmeri Citrobacter freundii Citrobacter koseri Citrobacter rodentium Citrobacter sedlakii Citrobacter werkmanii Citrobacter youngae Clostridium baratii Clostridium bifermentans Clostridium botulinum Clostridium butyricum Clostridium chauvoei Screening Criteria Used for Exclusion 1 X X X X X X 2 X X 3 X 4 5 X X X X X X X X X X X X X X X X X X X 6 7 8 X X X X X 9 X X X X X X X X X 10 X 11 X X 12 PCCL Campylobacter jejuni Page Reference MCM-9, p. 750-751 MCM-9, p. 752 MCM-9, p. 752 MCM-9, p. 934-935 MCM-9, p. 933-934 MCM-9, p. 933-934 MCM-9, p. 934-935 MCM-9, p. 933-934 MCM-9, p. 934-935 MCM-9, p. 935 MCM-9, p. 933-934 MCM-9, p. 934-935 MCM-9, p. 934-935 MCM-9, p. 621 , 629 MCM-9, p. 621 , 629 MCM-9, p. 621 , 629 MCM-9, p. 621 , 629 MCM-9, p. 621 , 629 MCM-9, p. 621 , 628-629 MCM-9, p. 702, 704 MCM-9, p. 702, 704 MCM-9, p. 702, 704 MCM-9, p. 489-490, 506 MCM-9, p. 489-490, 506 MCM-9, p. 911 MCM-9, p. 1021 MCM-9, p. 1021 MCM-9, p. 1021 MCM-9, p. 621 , 624-625 MCM-9, p. 791-792 MCM-9, p. 791-792 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 699, 703 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 A4 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Clostridium difficile Clostridium fallax Clostridium histolyticum Clostridium novyi Clostridium perfringens Clostridium ramosum Clostridium septicum Clostridium sordellii Clostridium sporogenes Clostridium tertium Clostridium tetani Collinsella aerofaciens Comamonas testosteroni Corynebacterium afermentans Corynebacterium argentoratense Corynebacterium bovis Corynebacterium diphtheriae Corynebacterium jeikeium Corynebacterium kutscheri Corynebacterium macginleyi Corynebacterium minutissimum Corynebacterium propinquum Corynebacterium pseudodiphthericum Corynebacterium pseudotuberculosis Corynebacterium striatum Corynebacterium ulcerans Corynebacterium urealyticum Corynebacterium xerosis Coxiella burnetii Delftia acidovorans Dermatophilus congolensis Dichelobacter nodosus Edwardsiella hoshinae Edwardsiella tarda Eggerthella lenta Ehrlichia chaffeensis Ehrlichia equi Ehrlichia ewingii Ehrlichia phagocytophila Ehrlichia sennetsu Eikenella corrodens Enterobacter aerogenes Enterobacter amnigenus Enterobacter asburiae Enterobacter cancerogenus Enterobacter cloacae Screening Criteria Used for Exclusion 1 X X X X X X X X X X X X X X 2 X 3 4 X X X X X 5 X X X X X X X X X X X X X X X 6 X 7 8 9 X X X X X X X X X X 10 11 12 PCCL Page Reference MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 889 MCM-9, p. 873, 875 MCM-9, p. 750-751 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-491 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 489-490 MCM-9, p. 1062-1063 MCM-9, p. 750-751 MCM-9, p. 520 MCM-8, p. 880-881 MCM-9, p. 702-704 MCM-9, p. 702-704 MCM-9, p. 872-873 MCM-9, p. 1046-1049 MCM-9, p. 1046-1049 MCM-9, p. 1046-1049 MCM-9, p. 1046-1049 MCM-9, p. 1046-1049 MCM-9, p. 621 , 625 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 A5 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Entembacter gergoviae Entembacter hormaechei Entembacter sakazakii Enterococcus avium Enterococcus casseliflavus Enterococcus durans Enterococcus faecalis Enterococcus faecium Enterococcus flavescens Enterococcus gallinarum Enterococcus hirae Enterococcus mundtii Enterococcus raffinosus Erysipelothrix rhusiopathiae Escherichia coli Eubacterium brachy Eubacterium combesii Eubacterium contortum Eubacterium cylindroides Eubacterium limosum Eubacterium moniliforme Eubacterium multiforme Eubacterium nodatum Eubacterium rectale Eubacterium saburreum Eubacterium saphenum Eubacterium sulci Eubacterium tenue Eubacterium timidum Ewingella americana Fibrobacter intestinalis Filifactor alocis Finegoldia magna Fluoribacter bozemanae Fluoribacter dumoffii Fluoribacter gormanii Francisella tularensis Fusobacterium mortiferum Fusobacterium necrophorum Fusobacterium nucleatum Fusobacterium periodonticum Fusobacterium ulcerans Fusobacterium varium Gardnerella vaginalis Gemella morbillorum Gordonia amarae Screening Criteria Used for Exclusion 1 X X X X X X X X X X X X X X X X X X X X X X X 2 3 4 X 5 X X X 6 7 8 9 X X X X X X X X X X X X X X X 10 11 12 X X X PCCL Escherichia coli Page Reference MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 431-432 MCM-9, p. 480 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 702-704 MCM-8, p. 880-881 MCM-9, p. 872-874 MCM-9, p. 862-863 MCM-9, p. 835 MCM-9, p. 835 MCM-9, p. 835 MCM-9, p. 816-817 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 508 MCM-9, p. 445 MCM-9, p. 520 A6 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Gordonia bronchialis Gordonia rubropertincta Gordonia sputi Gordonia terrae Granulicatella adiacens Haemophilusactinomycetemcomitans Haemophilus aphrophilus Haemophilus ducreyi Haemophilus haemolyticus Haemophilus influenzae Haemophilus parahaemolyticus Haemophilus parainfluenzae Haemophilus paraphrophilus Haemophilus segnis Hafnia alvei Helicobacter cinaedi Helicobacter fennelliae Helicobacter heilmannii Helicobacter pullorum Helicobacter pylori Kingella denitrificans Kingella kingae Klebsiella granulomatis Klebsiella ornithinolytica Klebsiella oxytoca Klebsiella pneumoniae Kluyvera ascorbata Kluyvera cryocrescens Lactobacillus sp. Legionella anisa Legionella birminghamensis Legionella cherrii Legionella cincinnatiensis Legionella feeleii Legionella hackeliae Legionella jordanis Legionella lansingensis Legionella longbeachae Legionella oakridgensis Legionella pneumophila Legionella rubrilucens Legionella sainthelensi Legionella tucsonensis Legionella wadsworthii Leifsonia aquatica Leptospira borgpetersenii Screening Criteria Used for Exclusion 1 X 2 3 X 4 5 X X X X X X X X X X X 6 7 8 X 9 X X X X X X X X X X X X 10 11 X X X X X X X X X X X X X X X X X X 12 PCCL Helicobacter pyori Legionella pneumophila Page Reference MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 445 MCM-9, p. 623, 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 636-637 MCM-9, p. 699 MCM-9, p. 949-950 MCM-9, p. 949-950 MCM-9, p. 949-950 MCM-9, p. 949-950 MCM-9, p. 621 , 625 MCM-9, p. 621 , 625 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 699, 702 MCM-9, p. 702-704 MCM-9, p. 702-704 MCM-9, p. 872-873 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 836 MCM-9, p. 485, 489 MCM-9, p. 963-965 A7 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Leptospira inadai Leptospira intermgans Leptospira kirschneri Leptospira meyeri Leptospira noguchii Leptospira santarosai Leptospira weilii Leptotrichia buccalis Lister! a ivanovii Listeria monocytogenes Listeria seeligeri Listeria welshimeri Mannheimia haemolytica Megamonas hypermegale Megasphaera sp. Methylobacterium mesophilicum * Methylobacterium zatmanii* Micromonas micros Moraxella atlantae Moraxella bovis Moraxella catarrhalis Moraxella caviae Moraxella cuniculi Moraxella lacunata Moraxella lincolnii Moraxella liquefaciens Moraxella nonliquefaciens Moraxella osloensis Moraxella ovis Morganella morganii Mycobacterium abscessus Mycobacterium africanum Mycobacterium asiaticum Mycobacterium avium Mycobacterium bovis Mycobacterium celatum Mycobacterium chelonae Mycobacterium conspicuum Mycobacterium fortuitum Mycobacterium genavense Mycobacterium gordonae Mycobacterium haemophilum Mycobacterium kansasii Mycobacterium leprae Mycobacterium malmoense Mycobacterium marinum Screening Criteria Used for Exclusion 1 X X X X 2 X X 3 4 5 X X X X X X X X X X X X X 6 7 8 X X X X X X X X X X X X X 9 X X X X X X X X X X X X 10 X 11 12 PCCL Mycobacterium avium Page Reference MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 963-965 MCM-9, p. 911 MCM-9, p. 474 MCM-9, p. 474 MCM-9, p. 474 MCM-9, p. 474 MCM-9, p. 621-622 MCM-9, p. 913 MCM-9, p. 862 MCM-9, p. 789 MCM-9, p. 789 MCM-9, p. 487 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 774-775 MCM-9, p. 700, 703 MCM9, p. 544 MCM-9, p. 546 MCM-9, p. 544, 549 MCM-9, p. 544 MCM-9, p. 544, 549 MCM9, p. 544 MCM9, p. 544 MCM9, p. 544 MCM9, p. 544 MCM-9, p. 544, 549-50 MCM9, p. 544 MCM9, p. 544 MCM-9, p. 544 MCM-9, p. 544, 548 MCM-9, p. 544, 548 A8 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Mycobacterium mucogenicum Mycobacterium peregrinum Mycobacterium porcinum Mycobacterium scrofulaceum Mycobacterium senegalense Mycobacterium shimoidei Mycobacterium simiae Mycobacterium smegmatis Mycobacterium szulgai Mycobacterium tuberculosis Mycobacterium ulcerans Mycobacterium xenopi Mycoplasma fermentans Mycoplasma genitalium Mycoplasma hominis Mycoplasma pneumoniae Mycoplasma salivarium Myroides odoratus Neisseria cinerea Neisseria elongate Neisseria flava Neisseria flavescens Neisseria gonorrhoeae Neisseria lactamica Neisseria meningitidis Neisseria mucosa Neisseria perflava Neisseria sicca Neisseria subflava Neisseria weaver! Nocardia asteroides Nocardia brasiliensis Nocardia caviae Nocardia farcinica Nocardia nova Nocardia otitidiscaviarum Nocardia pseudobrasiliensis Nocardia transvalensis Ochrobactrum anthropi Oligella ureolytica Oligella urethralis Orientia tsutsugamushi Paenibacillus alvei Paenibacillus macerans Pantoea agglomerans Pasteurella aerogenes Screening Criteria Used for Exclusion 1 2 X X X X X X 3 X 4 5 X X X X X X X X X X X X X 6 X X 7 8 X 9 X X X X X X X X X X X X X X X X X X X X X X X 10 11 12 PCCL Page Reference MCM9, p. 544 MCM9, p. 544 MCM9, p. 544 MCM-9, p. 544, 550 MCM9, p. 544 MCM-9, p. 544, 550 MCM-9, p. 544, 548 MCM9, p. 544 MCM-9, p. 544, 548 MCM-9, p. 544-546 MCM-9, p. 544, 549 MCM-9, p. 544, 549 MCM-9, p. 1004-1007 MCM-9, p. 1004-1007 MCM-9, p. 1004-1007 MCM-9, p. 1004-1007 MCM-9, p. 1004-1007 MCM-9, p. 780-781 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 601 MCM-9, p. 616 MCM-9, p. 601-602 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 616 MCM-9, p. 602 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 784 MCM-9, p. 775 MCM-9, p. 775 MCM-9, p. 1036-1037 MCM-9, p. 455, 458 MCM-9, p. 455, 458 MCM-9, p. 700 MCM-9, p. 621-622 A9 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Pasteurella caballi Pasteurella canis Pasteurella dagmatis Pasteurella multocida Pasteurella pneumotropica Pasteurella stomatis Peptococcus niger Peptostreptococcus anaerobius Peptostreptococcus asaccharolyticus Peptostreptococcus lactolyticus Peptostreptococcus prevotii Peptostreptococcus vaginalis Photobacterium damselae Plesiomonas shigelloides Porphyromonas asaccharolytica Porphyromonas catoniae Porphyromonas circumdentaria Porphyromonas endodontalis Porphyromonas gingivalis Porphyromonas levii Porphyromonas macacae Prevotella bivia Prevotella buccae Prevotella buccalis Prevotella corporis Prevotella dentalis Prevotella denticola Prevotella disiens Prevotella enoeca Prevotella heparinolytica Prevotella intermedia Prevotella loescheii Prevotella melaninogenica Prevotella nigrescens Prevotella oralis Prevotella oris Prevotella oulora Prevotella ruminicola Prevotella tannerae Prevotella veroralis Prevotella zoogleoformans Propionibacterium acnes Propionibacterium avidum Propionibacterium granulosum Propionibacterium propionicus Proteus mirabilis Screening Criteria Used for Exclusion 1 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 2 3 4 5 X X X X X X 6 7 8 9 X X 10 11 12 PCCL Plesiomonas shigelloides Page Reference MCM-9, p. 621-622 MCM-9, p. 621-622 MCM-9, p. 621-622 MCM-9, p. 621-622 MCM-9, p. 621-622 MCM-9, p. 621-622 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 723, 725 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 872-873 MCM-9, p. 700, 703 A10 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Proteus penneri Proteus vulgaris Providencia alcalifaciens Providencia rettgeri Providencia stuartii Pseudomonas aeruginosa Pseudomonas alcaligenes Pseudomonas fluorescens Pseudomonas pseudoalcaligenes Pseudomonas putida Pseudomonas stutzeri Pseudonocardia autotrophica Pseudoramibacter alactolyticus Psychrobacter phenylpyruvicus Rahnella aquatilis Ralstonia pickettii Rhodococcus equi Rhodococcus erythropolis Rhodococcus fascians Rhodococcus rhodnii Rhodococcus rhodochrous Rickettsia africae Rickettsia akari Rickettsia australis Rickettsia conorii Rickettsia felis Rickettsia honei Rickettsia japonica Rickettsia massiliae Rickettsia prowazekii Rickettsia rickettsii Rickettsia sibirica Rickettsia typhi Rothia dentocariosa Ruminococcus productus Saccharomonospora viridis Saccharopolyspora rectivirgula Salmonella bongori Salmonella choleraesuis Salmonella enteritidis Salmonella typhi Salmonella typhimurium Sebaldella termitidis Selenomonas artemidis Selenomonas dianae Selenomonas flueggei Screening Criteria Used for Exclusion 1 X X X X X X 2 3 4 X X X X X X X X X X X X 5 X 6 7 8 9 X X X X X X X X X X X X X X X X X X X X X X 10 11 X X X X 12 PCCL Salmonella enterica Page Reference MCM-9, p. 700, 703 MCM-9, p. 700, 703 MCM-9, p. 700, 703 MCM-9, p. 700, 703 MCM-9, p. 700, 703 MCM-9, p. 734-735 MCM-9, p. 734-735 MCM-9, p. 734-735 MCM-9, p. 734-735 MCM-9, p. 734-735 MCM-9, p. 734-735 MCM-9, p. 516, 519-520 MCM-9, p. 872-873 MCM-9, p. 774-775 MCM-9, p. 698-701 MCM-9, p. 750-751 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 1036-1037 MCM-9, p. 506 MCM-9, p. 862-863 MCM-9, p. 520, 526 MCM-9, p. 520, 526 MCM-9, p. 659-660, 679-670 MCM-9, p. 659-660, 679-670 MCM-9, p. 659-660, 679-670 MCM-9, p. 659-660, 679-670 MCM-8, p. 880-881 MCM-9, p. 911 MCM-9, p. 911 MCM-9, p. 911 A11 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Selenomonas infelix Selenomonas noxia Serratia ficaria Serratia marcescens Serratia odorifera Serratia plymuthica Serratia proteamaculans Serratia rubidaea Shigella boydii Shigella dysenteriae Shigella flexneri Shigella sonnei Sphingomonas paucimobilis Spirillum minus Staphylococcus aureus Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hyicus Staphylococcus intermedius Staphylococcus lugdunensis Staphylococcus saprophyticus Staphylococcus warneri Stenotrophomonas maltophilia Streptobacillus moniliformis Streptococcus acidominimus Streptococcus agalactiae Streptococcus anginosus Streptococcus bow's Streptococcus canis Streptococcus constellatus Streptococcus criceti Streptococcus equi Streptococcus gordonii Streptococcus intermedius Streptococcus milleri Streptococcus mitis Streptococcus mutans Streptococcus pneumoniae Streptococcus pyogenes Streptococcus salivarius Streptococcus sanguis Streptococcus sobrinus Streptococcus suis Streptococcus uberis Sutterella wadsworthensis Suttonella indologenes Screening Criteria Used for Exclusion 1 X X X 2 X 3 X 4 5 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 6 7 8 9 X X X X X X X X 10 11 X X X 12 PCCL Shigella sonnei Page Reference MCM-9, p. 91 1 MCM-9, p. 91 1 MCM-9, p. 700, 702 MCM-9, p. 700, 702 MCM-9, p. 700, 702 MCM-9, p. 700, 702 MCM-9, p. 700, 702 MCM-9, p. 700, 702 MCM-9, p. 679 MCM-9, p. 678-679 MCM-9, p. 678-679 MCM-9, p. 786-787 MCM-9, p. 381-382 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 390, 392 MCM-9, p. 750-751 MCM-9, p. 621 , 631 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 414 MCM-9, p. 911 MCM-9, p. 621 , 629 A12 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Bacteria Tatlockia maceachernii Tatlockia micdadei Tatumella ptyseos Treponema carateum Treponema pallidum Tropheryma whippelii Tsukamurella inchonensis Tsukamurella paurometabola Tsukamurella pulmonis Tsukamurella tyrosinosolvens Ureaplasma urealyticum Veillonella atypica Veillonella dispar Veillonella parvula Vibrio alginolyticus Vibrio cholerae Vibrio cincinnatiensis Vibrio fluvialis Vibrio furnissii Vibrio hollisae Vibrio mimicus Vibrio parahaemolyticus Vibrio vulnificus Wolinella succinogenes Yersinia bercovieri Yersinia enterocolitica Yersinia frederiksenii Yersinia intermedia Yersinia kristensenii Yersinia mollaretii Yersinia pestis Yersinia pseudotuberculosis Yersinia rohdei Yersinia ruckeri 540 Bacteria Screening Criteria Used for Exclusion 1 X X X X 125 2 X 14 3 X 10 4 X 37 5 117 6 7 7 0 8 X X X X X X X X X 29 9 X X X X X X X X X X X X X X 154 10 2 11 28 12 X X 5 PCCL Vibrio cholerae Yersinia enterocolitica PCCL =12 Page Reference MCM-9, p. 835 MCM-9, p. 835 MCM-9, p. 701 , 704 MCM-9, p. 988 MCM-9, p. 988 MCM-9, p. 1070-1071 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 520 MCM-9, p. 1004-1007 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 862-863 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 723 MCM-9, p. 911 MCM-9, p. 688 MCM-9, p. 688 MCM-9, p. 688 MCM-9, p. 688 MCM-9, p. 688 MCM-9, p. 689 MCM-9, p. 689 MCM-9, p. 688 MCM-9, p. 688 The bacteria identified by an asterisk were added to the microbial CCL universe by EPA as a result of nominations from the scientific community. A13 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Andes virus Apoi virus Australian bat lyssavirus Bagaza virus Bangui virus Banna virus Banzi virus Barmah Forest virus Batken virus Bayou virus Bebaru virus Bhanja virus BK virus Black creek canal virus Borna disease virus Bovine Ephemeral Fever virus Bovine Papular Stomatitis virus Bovine Spongiform Encephalopathy (BSE) agent Buffalopox virus Bunyamwera virus Bussuquara virus Bwamba virus California encephalitis virus Candiru virus complex Caraparu virus Catu virus Cercopithecine herpes virus 1 Chandipura virus Changuinola virus Chikungunya virus Chim virus Creutzfeld-Jokob Disease (CJD) agent Colorado tick fever virus Cote d'lvoire Ebola virus Notes Screening Criteria Used for Exclusion 1 I 2 3 X X _ 4 X X X X X X X X X X X X X X X X X X X X X X X X X 5 6 X 7 8 X X X 9 10 X X X 11 12 PCCL Reference MCM-9, p. 1502 Field's Virology, 5th Ed., p. 1153- 1158,1206 Field's Virology, 5th Ed., p. 1364 Field's Virology, 5th Ed., p. 1153- 1158,1199 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/7t hReport/sites/descriptions/Orthomv xoviridae/t hoaotovirus.htm MCM-9, p. 1501-1502 Field's Virology, 5th. Ed., p. 1024 MCM-9, p. 1486-1491 MCM-9, p. 1612-1613 MCM-9, p. 1501-1502 Field's Virology, 5th Ed., p. 1835 Field's Virology, 5th Ed., p. 1367 Field's Virology, 5th Ed., p. 2948, 2955-2956, 2963 MCM-9, p. 87-89 Field's Virology, 5th Ed. p. 2955- 2956 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 2895- 2897 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/IC TVdB/1 1000000.htm Field's Virology, 5th Ed., p. 443- 444, 3077-3078 MCM-9, p. 1486-1491 Field's Virology, 5th. Ed., p. 619, 1411-1412, 1432-1434 A14 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Cowpox virus Crimea-Congo Haemorrhagic Fever Virus Dakar bat virus Dengue virus Dhori virus Dobrava-Belgrade virus Dug be virus Duvenhage virus Eastern equine encephalitis virus Edge Hill virus Encephalomyocarditis virus European bat lyssavirus 1 European bat lyssavirus 2 European Tick-borne encephalitis virus Everglades virus Eyach virus Far eastern Tick-borne encephalitis virus Foot and mouth disease virus Ganjam virus Getah virus Guama virus Guanarito virus Guaroa virus Hantaan virus Hendra virus Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis delta virus Hepatitis E virus Hepatitis G virus HU39694 virus Hughes virus Human adenovirus A Human adenovirus B Human adenovirus C Human adenovirus D Notes Screening Criteria Used for Exclusion 1 | 2 3 X X X X 4 X X X X X X X X X X X X X X X 5 6 X X 7 8 X X X 9 10 X X X X X X X X X 11 X 12 PCCL Hepatitis A Hepatitis E Adenovirus Reference MCM-9, p. 1632 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1158, 1206 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1502 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1364 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 796, 840, 858-860 Field's Virology, 5th Ed., p. 1364 Field's Virology, 5th Ed., p. 1364 Field's Virology, 5th Ed., p. 1153- 1158, 1200-1203 MCM-9, p. 1486-1491 Krausset al., p. 87-89 Field's Virology, 5th Ed., p. 1153- 1158, 1200-1203 Field's Virology, 5th Ed., p. 796, 840, 858-860 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1024 MCM-9, p. 1486-1491 MCM-9, p. 1512 MCM-9, p. 1486-1491 MCM-9, p. 1502 MCM-9, p. 1478-1479 MCM-9, p. 1641, 1643-1644 MCM-9, p. 1437-1438 MCM-9, p. 1653 MCM-9, p. 1445-1447 http://www.cdc.gov/ncidod/disease s/hanta/hps/noframes/phvs/ecoloav .htm Field's Virology, 5th Ed., p. 1743- 1745 MCM-9, p. 1589-1591 MCM-9, p. 1589-1591 MCM-9, p. 1589-1591 A15 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Human adenovirus E Human adenovirus F Human astrovirus Human Coronavirus 229E Human Coronavirus OC43 Human enterovirus 68 Human enterovirus 70 Human enterovirus A Human enterovirus B Human enterovirus C Human enterovirus D Human Herpesvirus 1 Human Herpesvirus 2 Human Herpesvirus 3 Human Herpesvirus 4 Human Herpesvirus 5 Human Herpesvirus 6 Human Herpesvirus 7 Human Herpesvirus 8 Human Immunodeficiency Virus 1 Human Immunodeficiency Virus 2 Human papillomavirus Human parainfluenza virus 1 Human parainfluenza virus 2 Human parainfluenza virus 3 Human parainfluenza virus 4 Human parechovirus type 1 Human parechovirus type 2 Human Respiratory Syncytial virus Human Rhinovirus A Human Rhinovirus B Human T-Lymphotropic Virus 1 Igbo-ora virus llheus virus Influenza A virus Influenza B virus Influenza C virus Issyk-Kul virus Japanese encephalitis virus JC virus Junin virus Juquitiba virus Notes Human enterovirus D Human enterovirus D Screening Criteria Used for Exclusion 1 I 2 3 X X X X X X X X X X X X X X X 4 X X X X X 5 6 X X X X X X X X X X X X 7 8 X X 9 10 11 X X X X X X 12 PCCL Astrovirus Enterovirus Reference MCM-9, p. 1589-1591 MCM-9, p. 1589-1591 MCM-9, p. 1414-1415 MCM-9, p. 1414-1415 MCM-9, p. 1392-1394 MCM-9, p. 1392-1394 MCM-9, p. 1392-1394 MCM-9, p. 1392-1394 MCM-9, p. 1392-1394 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1524 MCM-9, p. 1309-1310 MCM-9, p. 1309-1310 MCM-9, p. 1601 MCM-9, p. 1352 MCM-9, p. 1352 MCM-9, p. 1352 MCM-9, p. 1352 MCM-9, p. 1393-1394 MCM-9, p. 1393-1394 MCM-9, p. 1361-1362 MCM-9, p. 1405-1406 MCM-9, p. 1405-1406 MCM-9, p. 1330-1331 Field's Virology, 5th Ed., p. 1024, 1048 MCM-9, p. 1486-1491 MCM-9, p. 1340-1341 MCM-9, p. 1340-1341 MCM-9, p. 1340-1341 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1612-1613 MCM-9, p. 1512 Field's Virology, 5th Ed., p. 1743- 1745 A16 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Karshi virus Kasokero virus Kedougou virus Kemerovo virus Kokobera virus Koutango virus Kyasanur forest disease virus Laguna Negra virus Lanjan virus Lassa virus Lebombo virus Lechiguanas virus Louping ill virus Lymphocytic choriomeningitis virus Machupo virus Madrid virus Marburg virus Marituba virus Mayaro virus Measles virus Menangle virus Mimivirus1 Mokola virus Molluscum contagiosum virus Monkeypox virus Monongahela virus Mucambo virus Mumps virus Murray Valley encephalitis virus New York virus Newcastle disease virus Nipah virus Norwalk-like viruses Nyando virus Ockelbo virus Notes Screening Criteria Used for Exclusion 1 | 2 3 X X X 4 X X X X X X X X X X X X X X X X X X X X 5 6 X X 7 8 X X 9 10 X X X X X X X 11 12 PCCL Calicivirus Reference MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/IC TVdB/1 1000000.htm Field's Virology, 5th Ed., p. 1153- 1158,1199 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1502 http://phene.cpmc.columbia.edu/IC TVdB/1 1000000.htm MCM-9, p. 1512 MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/7t hReport/sites/descriptions/Bunvavir idae/hantavirus.htm MCM-9, p. 1486-1491 MCM-9, p. 1512 MCM-9, p. 1512 MCM-9, p. 1486-1491 MCM-9, p. 1512 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1378-1379 http://www.cdc.gov/ncidod/eid/vol4 no2/philbev htm Field's Virology, 5th Ed., p. 627- 628, 637-638 Field's Virology, 5th Ed., p. 1363- 1364 MCM-9, p. 1631-1632 MCM-9, p. 1631-1632 http://phene.cpmc.columbia.edu/7t hReport/sites/descriptions/Bunvavir idae/hantavirus.htm MCM-9, p. 1486-1491 MCM-9, p. 1352 MCM-9, p. 1486-1491 MCM-9, p. 1501-1502 Field's Virology, 5th Ed., p. 1497- 1498 MCM-9, p. 1478-1479 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 A17 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Omsk haemorrhagic fever virus O'nyong-nyong virus Oran virus Orf virus Oriboca virus Oropouche virus Orungo virus Parvovirus B1 9 Phnom-Penh bat virus Picobirnavirus Piry virus Poliovirus Powassan virus Pseudocowpox virus Punta Toro virus Puumala virus Quaranfil Virus Rabies virus Reo virus Reston Ebola virus Rift Valley fever virus Rio Bravo virus Rocio virus Ross River virus Rotavirus A Rotavirus B Rotavirus C Rotavirus D Rotavirus E Rotavirus F Royal Farm virus Rubella virus Sabia virus Saimiriine herpesvirus 1 Salehabad virus Sandfly fever Naples virus Notes Human enterovirus Screening Criteria Used for Exclusion 1 | 2 3 X 4 X X * X X X X X X X X X X X X 5 6 X X 7 X 8 X X X X X X 9 10 X X X X X X X X X 11 X 12 PCCL Rotavirus Reference MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/7t hReport/sites/descriptions/Bunvavir idae/hantavirus.htm MCM-9, p. 1631-1640 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1623 Field's Virology, 5th Ed., p. 1153- 1158, 1206 MCM-9, p. 1456-1457 MCM-9, p. 1486-1491 MCM-9, p. 1392-1394 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 2948, 2960, 2963 MCM-9, p. 1486-1491 MCM-9, p. 1502 MCM-9, p. 1486-1491 MCM-9, p. 1471 Field's Virology, 5th Ed., p. 1897- 1900 MCM-9, p. 1512 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1153- 1158, 1206 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1456-1457 MCM-9, p. 1456-1457 MCM-9, p. 1456-1457 MCM-9, p. 1456-1457 MCM-9, p. 1456-1457 Field's Virology, 5th Ed., p. 1153- 1158, 1204 MCM-9, p. 1384 MCM-9, p. 1512 Field's Virology, 4th Ed., p. 2383, 2483, 251 1 , 2848 http://phene.cpmc.columbia.edu/IC TVdB/1 1041 008.htm MCM-9, p. 1486-1491 A18 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Viruses Sandfly fever virus group Saumarez Reef virus Sealpox virus Semliki Forest virus Seoul virus Sepik virus Sin Nombre virus Sindbis virus St. Louis encephalitis virus Sudan Ebola virus Suid herpesvirus Swine vesicular disease virus Tacaiuma virus Tamdy virus Tanapox virus Tataguine virus Thogoto virus Trubanaman virus Tyuleniy virus Usutu virus Variola virus Venezuelan Equine Encephalitis virus Vesicular stomatitis virus Wad Medani virus Wanowrie virus Wesselsbron virus West Nile virus Western Equine Encephalitis virus Wyeomyia virus Yaba monkey tumor virus Yellow fever virus Yogue virus Zaire Ebola virus Zika virus Zinga virus 21 9 Viruses Notes Vesicular exanthema of swine Screening Criteria Used for Exclusion 1 2 3 0 - X 0 | 26 456 X X X X X X _ X X X X X X X X X X X X X X X X X X 104 0 19 7 1 8 X X 18 9 0 10 X X X X X X X X 36 11 8 12 0 PCCL PCCL = 7 Reference MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1153- 1158,1206 MCM-9, p. 1632, 1634 MCM-9, p. 1486-1491 MCM-9, p. 1501-1502 MCM-9, p. 1486-1491 MCM-9, p. 1501-1502 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1512 Field's Virology, 4th Ed., p. 2385, 2484, 2707 Field's Virology, 5th Ed., p. 963 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1632, 1634 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1153- 1158, 1206 MCM-9, p. 1486-1491 MCM-9, p. 1631-1632 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 Field's Virology, 5th Ed., p. 1975- 1977 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1486-1491 MCM-9, p. 1632 MCM-9, p. 1486-1491 http://phene.cpmc.columbia.edu/IC TVdB/1 1000000.htm MCM-9, p. 1512 MCM-9, p. 1486-1491 http://www.cdc.aov/mmwr/preview/ mmwrhtm 1/00001 253.htm 1This virus-like agent was added to the microbial CCL universe by EPA as a result of nominations from the scientific community. 2This virus group was added to the microbial CCL universe by EPA. A19 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Protozoa Acanthamoeba astronyxis Acanthamoeba castellani Acanthamoeba culbertsoni Acanthamoeba hatchetti Acanthamoeba palestinensis Acanthamoeba polyphaga Acanthamoeba rhysoides Babesia bovis Babesia divergens Babesia gibsoni Babesia microti Balamuthia mandrillaris Balantidium coli Blastocystis hominis Cryptosporidium parvum 1 Cyclospora cayetanensis Dientamoeba fragilis Encephalitozoon cuniculi Encephalitozoon hellem Encephalitozoon intestinalis Entamoeba chattoni Entamoeba histolytica Entamoeba moshkovskii Enterocytozoon bieneusi Giardia duodenalis 1 Isospora belli Leishmania aethiopica Leishmania amazonensis Leishmania braziliensis Leishmania chagasi Leishmania donovani Leishmania guyanensis Leishmania infantum Leishmania lainsoni Leishmania major Leishmania mexicana Leishmania naiffi Leishmania panamensis Leishmania peruviana Leishmania pifanoi Leishmania shawi Screening Criteria Used for Exclusion 1 I 2 3 4 X X X X 5 X X X X X X X X X X X X X X X 6 7 8 X X 9 X X X X X X X X 10 11 = X X X X X 12 PCCL Blastocystis hominis Cyclospora cayetanensis Microsporidia Entamoeba histolytica Isospora belli Reference MCM-9, p. 2082 MCM-9, p. 2082-2084 MCM-9, p. 2082-2084 MCM-9, p. 2082 MCM-9, p. 2082, Krauss et al., p. 264-268 MCM-9, p. 2082 MCM-9, p. 2082 MCM-9, p. 2051 MCM-9, p. 2051 MCM-9, p. 2051 MCM-9, p. 2051 MCM-9, p. 2030, 2084 MCM-9, p. 2106-2107 MCM-9, p. 2103-2104 MCM-9 p. 2133-2135 MCM-9 p. 2133-2135 htto://www. ita.be/ita/DistanceLearnina/LectureNote sVandenEndenE/06 Amoebiasisp2.htm#IX 450 htto://www. ita.be/ita/DistanceLearnina/LectureNote sVandenEndenE/06 Amoebiasisp2.htm#IX 450 MCM-9 p. 2133-2135 MCM-9, p. 2057-2158 MCM-9, p. 2057-2158 MCM-9, p. 2057-2158 MCM-9, p. 2057-2158 MCM-9, p. 2057-2158 MCM-9, p. 2057-2158, Krauss et al., p. 282-284 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 A20 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Protozoa Leishmania tropica Leishmania venezuelensis Naegleria fowleri Nosema africanum Nosema ceylonensis Nosema connori Nosema ocularum Pentatrichomonas hominis Plasmodium falciparum Plasmodium knowlesi Plasmodium malariae Plasmodium ovale Plasmodium simium Plasmodium vivax Retortamonas intestinalis Sarcocystis hominis Sarcocystis lindermanni Sarcocystis suihominis Toxoplasma gondii Trachipleistophora hominis Trichomonas tenax Trichomonas vaginalis Trypanosoma brucei Trypanosoma cruzi Vittaforma corneae 66 Protozoa Screening Criteria Used for Exclusion 1 I 2 0 | 0 3 X 1 4 X X X X X X X X X X 29 5 X X X 3 6 0 7 X X X 4 8 X X X X X 7 9 7 10 0 11 = X 6 12 0 PCCL Naegleria fowleri Toxoplasma gondii PCCL = 7 Reference MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9, p. 2133-2135, Palmer et al., p. 609 MCM-9, p. 2133-2135, Palmer et al., p. 609 MCM-9, p. 2133-2135, Palmer et al., p. 609 MCM-9, p. 2133-2135 MCM-9, p. 2093 MCM-9, p. 2040 MCM-9, p. 2040 MCM-9, p. 2040 MCM-9, p. 2040 MCM-9, p. 2040 MCM-9, p. 2040 MCM-9, p. 2093 MCM-9, p. 2114-2115 MCM-9, p. 2114-2115 MCM-9, p. 2114-2115 MCM-9 p. 2133-2134 MCM-9, p. 2032. 2034, 2093 MCM-9, p. 2104-2105 MCM-9, p. 2057-2058 MCM-9, p. 2057-2058 MCM-9 p. 2133-2134 Cryptosporidium and Giardia are considered to be regulated by the Long Term Surface Water Treatment Rule (LT-2). These organisms are not listed on CCL3. A21 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Acanthocephalus rauschi Achillurbainia nouveli Achillurbainia recondite Alaria americana Alaria marcianae Amphimerus pseudofelineus Anatrichosoma cutaneum Ancylostoma braziliense Ancylostoma caninum Ancylostoma ceylanicum Ancylostoma duodenale Ancylostoma malayanum Anisakis physeteris Anisakis simplex Aonchotheca philippinensis Apophallus donicus Artyfechinostomum mehrai Ascaris lumbricoides Ascaris suum Ascocotyle sp. Australobilharzia terrigalensis Baylisascaris procyonis Bertiella mucronata Bertiella studeri Bilharziella polonica Bolbosoma sp. Brugia beaveri Brugia guyanensis Brugia malayi Brugia pahangi Brugia timori Bunostomum phlebotomum Calodium hepaticum Carneocephallus brevicaea Cathaemasia cabrerai Centrocestus armatus Centrocestus formosanus Cheilospirura sp. Clinostomum complanatum Contracaecum osculatum Corynosoma strumosum Cryptocotyle lingua Cyclodontostomum purvisi Synonyms and Notes Opisthorchis quayaquilensis Paracapillaria philippinensis Artyfechinostomum malayanum Phagicola longa Screening Criteria Used for Exclusion 1|2|3 4 X X X X X 5 | 6 7 X X X X X X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Asford and Crewe, 2003, p. 93 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 50 Ashford and Crewe, 2003, p. 29 Ashford and Crewe, 2003, p. 30 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 88 Ashford and Crewe, 2003, p. 68 Ashford and Crewe, 2003, p. 69 Ashford and Crewe, 2003, p. 69 Ashford and Crewe, 2003, p. 69 Ashford and Crewe, 2003, p. 69 Ashford and Crewe, 2003, p.75 Ashford and Crewe, 2003, p. 75 Ashford and Crewe, 2003, p. 89 Ashford and Crewe, 2003, p. 40 Ashford and Crewe, 2003, p. 35 Ashford and Crewe, 2003, p. 76 Ashford and Crewe, 2003, p. 77 Ashford and Crewe, 2003, p. 44 Ashford and Crewe, 2003, p. 31 Ashford and Crewe, 2003, p. 77 Ashford and Crewe, 2003, p. 59 Ashford and Crewe, 2003, p. 59 Ashford and Crewe, 2003, p. 31 Ashford and Crewe, 2003, p. 93 Ashford and Crewe, 2003, p. 81 Ashford and Crewe, 2003, p. 81 Ashford and Crewe, 2003, p. 82 Ashford and Crewe, 2003, p. 82 Ashford and Crewe, 2003, p. 82 Ashford and Crewe, 2003, p. 112 Ashford and Crewe, 2003, p. 89 Ashford and Crewe, 2003, p. 47 Ashford and Crewe, 2003, p. 35 Ashford and Crewe, 2003, p. 40 Ashford and Crewe, 2003, p. 41 Ashford and Crewe, 2003. p. 81 Ashford and Crewe, 2003, p. 29 Ashford and Crewe, 2003, p. 76 Ashford and Crewe, 2003, p. 93 Ashford and Crewe, 2003, p. 41 Ashford and Crewe, 2003, p. 69 A22 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Dicmcoelium dendriticum Dicmcoelium hospes Dioctophyme renale Dipetalonema arbuta Dipetalonema reconditum Diphyllobothrium cameroni Diphyllobothrium cordatum Diphyllobothrium dalliae Diphyllobothrium dendriticum Diphyllobothrium elegans Diphyllobothrium erinaceieuropaei Diphyllobothrium hians Diphyllobothrium houghtoni Diphyllobothrium klebanovskii Diphyllobothrium lanceolatum Diphyllobothrium latum Diphyllobothrium mansonoides Diphyllobothrium nihonkaiense Diphyllobothrium orcini Diphyllobothrium pacificum Diphyllobothrium scoticum Diphyllobothrium stemmacephalum Diphyllobothrium theileri Diplogonoporus balaenopterae Diplogonoporus brauni Diplogonoporus fukuokaensis Diplostomum spathaceum Dipylidium caninum Dirofilaria immitis Dirofilaria repens Dirofilaria striata Dirofilaria subdermata Dirofilaria tenuis Dirofilaria ursi Dracunculus insignis Dracunculus medinensis Drepanidotaenia lanceolata Echinochasmus japonicus Echinochasmus jiufoensis Echinochasmus perfoliatus Echinococcus granulosus Synonyms and Notes Spirometra erinaceieuropaei, Spirometra erinacei, Prometra mansoni Spirometra houghtoni Spirometra mansonoides Note: limited information available Diphyllobothrium yonagoensis Spirometra theileri Diplogonoporus grandis Dirofilaria ursi Dirofilaria subdermata Dracunculus medinensis Screening Criteria Used for Exclusion 1|2|3 4 X X X X X X X X 5 | 6 7 X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 47 Ashford and Crewe, 2003, p. 48 Ashford and Crewe, 2003, p. 87 Ashford and Crewe, 2003, p. 83 MCM-8, p. 634, 1209 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 55 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 56 Ashford and Crewe, 2003, p. 57 Ashford and Crewe, 2003, p. 57 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 57 Ashford and Crewe, 2003, 57 Ashford and Crewe, 2003, 57 Ashford and Crewe, 2003, p. 30 Ashford and Crewe, 2003, p. 60 Ashford and Crewe, 2003, p. 83 Ashford and Crewe, 2003, p. 83 Ashford and Crewe, 2003, p. 83 Ashford and Crewe, 2003, p. 84 Ashford and Crewe, 2003, p. 84 Ashford and Crewe, 2003, p. 84 Ashford and Crewe, 2003, p. 78 Ashford and Crewe. 2003, p. 78 Ashford and Crewe, 2003, p. 61 Ashford and Crewe, 2003, p. 35 Ashford and Crewe, 2003, p. 36 Ashford and Crewe, 2003, p. 36 Ashford and Crewe, 2003, p. 62 A23 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Echinococcus multilocularis Echinococcus oligarthus Echinococcus vogeli Echinoparyphium recurvatum Echinostoma cinetorchis Echinostoma echinatum Echinostoma hortense Echinostoma ilocanum Echinostoma jassyense Echinostoma macrorchis Echinostoma malayanum Echinostoma revolutum Enterobius gregorii Enterobius vermicularis Episthmium caninum Eucoleus aerophilus Eurytrema pancreaticum Eustrongylides sp. Fasciola gigantica Fasciola hepatica Fasciola indica Fasciolopsis buski Fibricola seoulensis Gastrodiscoides hominis Gigantobilharzia huttoni Gigantobilharzia sturniae Gnathostoma doloresi Gnathostoma hispidum Gnathostoma nipponicum Gnathostoma spinigerum Gongylonema pulchrum Gymnophalloides sp. Haemonchus contortus Haplorchis pumilo Haplorchis taichui Haplorchis vanissima Haplorchis yokogawai Heterobilharzia americana Heterophyes dispar Heterophyes heterophyes Heterophyes nocens Heterophyopsis continua Himasthala muehlensi Hymenolepis diminuta Synonyms and Notes Echinostoma melis Fasciola gigantica Neodiplostomum seoulense Fischeroederius elongatus Screening Criteria Used for Exclusion 1|2|3 4 5 | 6 7 X X X X X X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 62 Ashford and Crewe, 2003, p. 62 Ashford and Crewe, 2003, p. 62 Ashford and Crewe, 2003, p. 36 Ashford and Crewe, 2003, p. 36 Ashford and Crewe, 2003, p. 37 Ashford and Crewe, 2003, p. 37 Ashford and Crewe, 2003, p. 37 Ashford and Crewe, 2003, p. 38 Ashford and Crewe, 2003, p. 37 Ashford and Crewe, 2003, p. 38 Ashford and Crewe, 2003, p. 38 Ashford and Crewe, 2003, p. 75 Ashford and Crewe, 2003, p. 75 Ashford and Crewe, 2003, p. 38 Ashford and Crewe, 2003, p. 89 Ashford and Crewe, 2003, p. 48 Ashford and Crewe, 2003, p. 87 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 30 Ashford and Crewe, 2003, p. 40 Ashford and Crewe, 2003, p. 31 Ashford and Crewe, 2003, p. 32 Ashford and Crewe, 2003, p. 78 Ashford and Crewe. 2003, p. 79 Ashford and Crewe. 2003, p. 79 Ashford and Crewe, 2003, p. 79 Ashford and Crewe, 2003, p. 80 Ashford and Crewe, 2003, p. 40, 138 Ashford and Crewe, 2003, p. 71 Ashford and Crewe, 2003, p. 42 Ashford and Crewe, 2003, p. 42 Ashford and Crewe, 2003, p. 42 Ashford and Crewe, 2003, p. 42 Ashford and Crewe, 2003, p. 32 Ashford and Crewe, 2003, p. 43 Ashford and Crewe, 2003, p. 43 Ashford and Crewe, 2003, p. 43 Ashford and Crewe, 2003, p. 43 Ashford and Crewe, 2003, p. 38 Ashford and Crewe, 2003, p. 61 A24 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Hymenolepis nana Hypoderaeum conoideum Inermicapsifermadagascariensis Isopamrchis hypselobagri Lagochilascaris minor Ligula intestinalis Loa loa Macracanthorhynchus hirudinaceus Macracanthorhynchus ingens Mammomonogamus laryngeus Mammomonogamus nasicola Mansonella ozzardi Mansonella perstans Mansonella rodhaini Mansonella semiclarum Mansonella streptocerca Marshallagia marshalli Mathevotaenia symmetrica Mecistocirrus digitatus Meningonema peruzzii Mesocestoides lineatus Mesocestoides variabilis Metagonimus minutus Metagonimus yokogawai Metastrongylus elongatus Metorchis albidus Metorchis conjunctus Microfilaria bolivarensis Micronema deletrix Moniezia expansa Moniliformis moniliformis Multiceps brauni Multiceps glomeratus Multiceps longihamatus Multiceps multiceps Multiceps serialis Nanophyetus salmincola Necator americanus Nematodirus abnormalis Neodiplostomum sp. Synonyms and Notes Microfilaria semiclarum Note: Original publication ambiguous, probably not a human pathogen. Halicephalobus gingivalis Taenia brauni Note: Unreliably identified, probably not a human pathogen. Fibricola seoulensis Screening Criteria Used for Exclusion 1|2|3 4 X X X X X X X 5 | 6 7 X X X X X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 61 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 59 Ashford and Crewe, 2003, p. 31 Ashford and Crewe, 2003, p. 77 Ashford and Crewe, 2003, p. 57 Ashford and Crewe, 2003, p. 84 Ashford and Crewe, 2003, p. 93 Ashford and Crewe, 2003, p. 93 Ashford and Crewe, 2003, p. 71 Ashford and Crewe, 2003, p. 71 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 86 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 71 Ashford and Crewe, 2003, p. 60 Ashford and Crewe, 2003, p. 113 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 61 Ashford and Crewe, 2003, p. 62 Ashford and Crewe, 2003, p. 44 Ashford and Crewe, 2003, p. 44 Ashford and Crewe, 2003, p. 74 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 85 Ashford and Crewe, 2003, p. 67 Ashford and Crewe, 2003, p. 60 Ashford and Crewe, 2003, p. 94 Ashford and Crewe, 2003, p. 62 Ashford and Crewe, 2003, p. 63 Ashford and Crewe, 2003, p. 63 Ashford and Crewe, 2003, p. 63 Ashford and Crewe, 2003, p. 63 Ashford and Crewe, 2003, p. 52 Ashford and Crewe, 2003, p. 70 Ashford and Crewe, 2003, p. 113 Ashford and Crewe, 2003, p. 30 A25 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Oesophagostomum aculeatum Oesophagostomum bifurcum Oesophagostomum stephanostomum Onchocerca volvulus Opisthorchis (Chlonorchis) sinensis Opisthorchis felineus Opisthorchis guayaquilensis Opisthorchis noverca Opisthorchis viverrini Orientobilharzia turkestanica Ornithobilharzia sp. Ostertagia ostertagi Paragonimus africanus Paragonimus bankokensis Paragonimus caliensis Paragonimus heterotremus Paragonimus hueitungensis Paragonimus kellicotti Paragonimus mexicanus Paragonimus miyazakii Paragonimus ohirai Paragonimus phillipinensis Paragonimus sadoensis Paragonimus siamensis Paragonimus skrjabini Paragonimus uterobilateralis Paragonimus westermani Parascaris equorum Parastrongylus cantonensis Parastrongylus costaricensis Pearsonema plica Pelodera strongyloides Phaneropsolus bonnei Philophthalmus lacrymosus Phocanema decipiens Physaloptera caucasica Synonyms and Notes Clonorchis sinensis Note: Doubtful record, probably not a human pathogen. Note: Human infection unknown Note: Human infection unknown Paragonimus skrjabini Paragonimus westermanii Paragonimus ohirai Note: Capillaria plica according to http://www.biolib.cz/en/taxo n/id87491 and Screening Criteria Used for Exclusion 1|2|3 4 X 5 | 6 7 X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 70 Ashford and Crewe, 2003, p. 70 Ashford and Crewe, 2003, p. 70 Ashford and Crewe, 2003, p. 86 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 46 Ashford and Crewe, 2003, p. 110 Ashford and Crewe, 2003, p. 47 Ashford and Crewe, 2003, p. 32 Kolarova, 2007 Ashford and Crewe, 2003, p. 71 Ashford and Crewe, 2003, p. 50 Ashford and Crewe, 2003, p. 110 Ashford and Crewe, 2003, p. 1 1 1 Ashford and Crewe, 2003, p. 50 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 50 Ashford and Crewe, 2003, p. 50 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 51 Palmer etal., 1998, p. 736 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 51 Ashford and Crewe, 2003, p. 77 Ashford and Crewe, 2003, p. 74 Ashford and Crewe, 2003, p. 74 MCM-8, p. 1134 Ashford and Crewe, 2003, p. 67 Ashford and Crewe, 2003, p. 48 Ashford and Crewe, 2003, p. 39 Ashford and Crewe, 2003, p. 76 Ashford and Crewe, 2003, p. 79 A26 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Physaloptera transfuga Plagiorchis harinasutai Plagiorchis javensis Plagiorchis muris Plagiorchis philippinensis Poikilorchis congolensis Procerovum calderoni Prohemistomum vivax Prosthodendrium molenkampi Pseudamphistomum aethiopicum Pseudamphistomum truncatum Psilorchis hominis Pygidiopsis summa Pyramicocephalus anthrocephalus Raillietina celebensis Raillietina demerariensis Rhabditis elongate Rhabditis inermis Rhabditis niellyi Rhabditis pellio Rictularia sp. Schistocephalus solidus Schistosoma bovis Schistosoma haematobium Schistosoma intercalatum Schistosoma japonicum Schistosoma malayensis Schistosoma mansoni Schistosoma mattheei Schistosoma mekongi Schistosoma rodhaini Schistosoma spindale Schistosomatium douthitti Setaria equina Spirocerca lupi Stellantchasmus falcatus Stictodora fuscata Strongyloides fuelleborni Synonyms and Notes Note: Validity questionable, probably not a human pathogen. Note: Old and doubtful record, probably not a human pathogen. Note: Probably pseudoparasite, not a human pathogen. Screening Criteria Used for Exclusion 1|2|3 4 X 5 | 6 7 X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 80 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 49 Ashford and Crewe, 2003, p. 44 Ashford and Crewe, 2003, p. 29 Ashford and Crewe, 2003, p. 48 Ashford and Crewe, 2003, p. 47 Ashford and Crewe, 2003, p. 47 Ashford and Crewe, 2003, p. 110 Ashford and Crewe, 2003, p. 45 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 60 Ashford and Crewe, 2003, p. 60 Ashford and Crewe, 2003, p. 67 Ashford and Crewe, 2003, p. 67 Ashford and Crewe, 2003, p. 1 1 1 Ashford and Crewe, 2003, p. 1 1 1 Ashford and Crewe, 2003, p. 80 Ashford and Crewe, 2003, p. 58 Ashford and Crewe, 2003, p. 32 Ashford and Crewe, 2003, p. 32 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 33 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 86 Ashford and Crewe, 2003, p. 81 Ashford and Crewe, 2003, p. 45 Ashford and Crewe, 2003, p. 45 Ashford and Crewe, 2003, p. 67 A27 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Strongyloides papillosus Strongyloides ransomi Strongyloides stercoralis Strongyloides westeri Syphacea obvelata Taenia crassiceps Taenia saginata Taenia solium Taenia taeniaeformis Teladorsagia circumcincta Ternidens deminutus Thelazia californiensis Thelazia callipaeda Thelazia rhodesii Toxascaris leonina Toxocara canis Toxocara cati Trichinella britovi Trichinella nativa Trichinella nelson! Trichinella pseudospiralis Trichinella spiralis Trichinella T5 Trichobilharzia brevis Trichobilharzia ocellata Trichobilharzia stagnicolae Trichostrongylus affinis Trichostrongylus axei Trichostrongylus brevis Trichostrongylus calcaratus Trichostrongylus capricola Trichostrongylus colubriformis Trichostrongylus instabilis Trichostrongylus lerouxi Trichostrongylus orientalis Trichostrongylus probolurus Trichostrongylus skrjabini Trichostrongylus vitrinus Trichuris suis Trichuris trichiura Trichuris vulpis Uncinaria stenocephala Watsonius watsoni Wuchereria bancrofti Synonyms and Notes Note: Unknown as an human parasite. Trichinella murrelli Note: Experimental infection only Screening Criteria Used for Exclusion 1|2|3 4 X X 5 | 6 7 X X X X X X X X X X X X X X X X X X X X X X 8 | 9 10 X X X X X X X X X X X X X X X X X X X X 11 | 12 PCCL Reference Ashford and Crewe, 2003, p. 68 Ashford and Crewe, 2003, p. 68 Ashford and Crewe, 2003, p. 68 Ashford and Crewe, 2003, p. 68 Ashford and Crewe, 2003, p. 75 Ashford and Crewe, 2003, p. 63 Ashford and Crewe, 2003, p. 64 Ashford and Crewe, 2003, p. 64 Ashford and Crewe, 2003, p. 64 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 70 Ashford and Crewe, 2003, p. 80 Ashford and Crewe, 2003, p. 80 MCM-8, p. 363 Ashford and Crewe, 2003, p. 113 Ashford and Crewe, 2003, p. 77 Ashford and Crewe, 2003, p. 78 Ashford and Crewe, 2003, p. 87 Ashford and Crewe, 2003, p. 88 Ashford and Crewe, 2003, p. 88 Ashford and Crewe, 2003, p. 88 Ashford and Crewe, 2003, p. 88 Ashford and Crewe, 2003, p. 87 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 34 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 72 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 73 Ashford and Crewe, 2003, p. 74 Ashford and Crewe, 2003, p. 89 Ashford and Crewe, 2003, p. 89 Ashford and Crewe, 2003, p. 90 Ashford and Crewe, 2003, p. 112 Ashford and Crewe, 2003, p. 40 Ashford and Crewe, 2003, p. 86 A28 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Helminths Wuchereria lewisi 287 Helminths Synonyms and Notes Wuchereria bancrofti Screening Criteria Used for Exclusion 1 I 2 3 0 | 0 0 4 X 25 5 | 6 0 | 0 7 106 8 | 9 0 | 0 10 156 11 12 0 0 PCCL PCCL = 0 Reference Ashford and Crewe, 2003, p. 86 A29 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Absidia corymbifera Acremonium alabamense Acremonium curvulum Acremonium falciforme Acremonium kiliense Acremonium potronii Acremonium recifei Acremonium roseogriseum Acremonium strictum Acrophialophora fusispora Actinomadura madurae Actinomadura pelletieri Alternaria alternata Alternaria chlamydospora Alternaria dianthicola Alternaria infectoria Alternaria longipes Alternaria stemphyloides Alternaria tenuissima Aphanoascus fulvescens Apophysomyces elegans Arthrinium phaeospermum Arthrographis kelrae * Aspergillus candidus Aspergillus clavatus Aspergillus fisherianus Aspergillus flavipes Aspergillus flavus group Aspergillus fumigatus group Aspergillus glaucus Aspergillus nidulans group Aspergillus niger Aspergillus oryzae Aspergillus terreus group Aspergillus versicolor Aspergillus wentii Aureobasidium pullulans Basidiobolus ranarum Beauveria bassiana Bipolaris australiensis Bipolaris hawaiiensis Bipolaris spicifera Synonyms and Notes Actinomadura spp. are bacteria, not fungi Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Aspergillus fumigatus Reference MCM-9, p. 1839-1840, 1848 MCM-9, p. 1828 MCM-9, p. 1828 MCM-9, p. 1828 MCM-9, p. 1828 MCM-9, p. 1828 MCM-9, p. 1828 Howard, p. 384 MCM-9, p. 1828 MCM-9, p. 1802, 1808 MCM-9, p. 516, 520 MCM-9, p. 516, 520 MCM-9, p. 1898 MCM-9, p. 1898 MCM-9, p. 1898 MCM-9, p. 1898 MCM-9, p. 1898 httD://www.doctorfunaus.ora/the funai/Alternaria.htm MCM-9, p. 1898 MCM-9, p. 1802, 1808 MCM-9, p. 1839-1840 httD://www.doctorfunaus.ora/the funai/Arthrinium.htm Warris et al., 2001 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1807 MCM-9, p. 1898 MCM-9, p. 1839-1840 MCM-9, p. 1802, 1828 MCM-9, p. 1898 MCM-9, p. 1898 MCM-9, p. 1898 A30 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Blastomyces dermatitidis Blastoschizomyces capitatus Botryomyces caespitosus Botryosphaeria subglobosa Candida albicans Candida catenulata Candida famata Candida glabrata Candida guilliermondii Candida haemulonis Candida intermedia Candida kefyr Candida krusei Candida lambica Candida lipolytica Candida lusitaniae Candida norvegensis Candida parapsilosis Candida rugosa Candida tropicalis Candida viswanathii Candida zeylanoides Cephaliophora irregularis Cerinosterus cyanescens Chaetomium atrobtunneum Chaetomium funicola Chaetomium globosum Chaetomium perpulchrum Chaetomium strumarium Chaetophoma dermo-unguis Chlamydoabsidia padenii Synonyms and Notes Neodeightonia subglobosa, Sphaeropsis subglobosa Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 X 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference MCM-9, p. 1861 MCM-9, p. 1762, 1770-1771 Howard p. 575 httD://newDortal.abif.ora/SDecies 71 437351 3 and http://www.cabri.ora/CABRI/srs- bin/waetz?-newld+-e+- paae+aResult+[CABI FIL- id:'IMI%20287616'l MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 httD://www.doctorfunaus.ora/the funai/Candida spp.htm MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 MCM-9, p. 1764, 1770-1771 http://www.doctorfunaus.ora/im aaeban/svnonvms/Cephaliopho ra.htm http://www.doctorfunaus.ora/the funai/Sporothrix.htm MCM-9, p. 1802, 1823-1824 http://www.doctorfunaus.ora/the funai/Chaetomium.htm MCM-9, p. 1802, 1823-1824 httD://www.doctorfunaus.ora/the funai/Chaetomium.htm MCM-9, p. 1802, 1823-1824 http://www.doctorfunaus.ora/im aaeban/svnonvms/Chaetophom a. htm http://www.doctorfunaus.ora/im aaeban/svnonvms/Chlamvdoab sidia.htm A31 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Chlorella protothecoides Chrysosporium zonatum* Chrysonilia sitophila Cladophialophora arxii Cladophialophora bantiana Cladophialophora boppii Cladophialophora carrionii Cladophialophora devriesii Cladorrhinum bulbillosum Cladosporium cladosporioides Cladosporium elatum Cladosporium oxysporum Cladosporium sphaerosphermum Coccidioides immitis Cokeromyces recurvartus Colletotrichum coccodes Colletotrichum dematium Colletotrichum gloeosporioides Conidiobolus coronatus Conidiobolus incongruus Conidiobolus lamprauges Coniothyrium fuckelii Coprinus cinereus Cryptococcus neoformans Cunninghamella bertholletiae Curvularia brachyspora Curvularia clavata Curvularia geniculata Curvularia lunata Curvularia pallescens Curvularia senegalensis Curvularia verucculosa Cylindrocarpon cyanescens Cylindrocarpon lichenicola Synonyms and Notes Note: Chlorella spp. are algae, not fungi. Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference httD://DCD.oxfordiournals.ora/cai /content/abstract/9/1 787 Arvanitidou et al., 1999 httD://www.doctorfunaus.ora/im aaeban/svnonvms/Chrvsonilia. htm MCM-9, p. 1898, 1900-1902 MCM-9, p. 1898, 1900-1902 MCM-9, p. 1898, 1900-1902 MCM-9, p. 1898, 1900-1902 MCM-9, p. 1898, 1900-1902 httD://uwadmnweb. uwvo.edu/bo tanv/Soil%20Microfunaal%20C ollection/RMF%20collection%2 0(Rockv%20Mountain%20Funa ibartll.htm MCM-9, p. 1898, 1904 httD://www.doctorfunaus.ora/the funai/CladosDorium.htm httD://www.doctorfunaus.ora/the funai/CladosDorium.htm MCM-9, p. 1898, 1904 MCM-9, p. 1861 MCM-9, p. 1839-1840 Howard p. 662-664 Howard p. 662-664 Howard p. 662-664 MCM-9, p. 1839-1840 MCM-9, p. 1839-1840 Howard p. 133-137 httD://www.doctorfunaus.ora/im aaeban/svnonvms/Coniothvriu m.htm MCM-9, p. 1802, 1826 MCM-9, p. 1765-1767, 1770- 1771 MCM-9, p. 1839-1840, 1849 Howard p. 584-586 Howard p. 584-586 MCM-9, p. 1918 MCM-9, p. 1918 Howard p. 584-586 Howard p. 584-586 Howard p. 584-586 MCM-9, p. 1802, 1808, 1818 MCM-9, p. 1802, 1808, 1818 A32 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Cylindrocarpon vaginae Dichotomophthora portulacae Dichotomophthompsis nymphaerum Dissitimurus exedrus Doratomyces stemonitis Drechslera biseptata Emmonsia crescens Emmonsia pan/a Engyodontium album Epidermophyton floccosum Exophiala dermatitidis Exophiala jeanselmei Exophiala moniliae Exophiala pisciphila Exophiala psychmphila Exophiala salmonis Exophiala spinifera Exserohilum longirostratum Exserohilum macginnisii Fusarium aquaeductuum Fusarium chlamydosporum Fusarium dimerum Fusarium incarnatum Fusarium moniliforme Fusarium napiforme Fusarium nivale Fusarium oxysporum Fusarium pallidoroseum Fusarium proliferatum Fusarium sacchari Fusarium solani Fusarium subglutinans Fusarium ventricosum Fusarium verticillioides Geotrichum candidum* Hansenula anomala Synonyms and Notes Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Exophiala jeanselmei Fusarium solani Reference Howard p. 394 httD://www.doctorfunaus.ora/im aaeban/svnonvms/DichotomoD hthora.htm httD://www.doctorfunaus.ora/im aaeban/svnonvms/DichotomoD hthoroDsis.htm Howard p. 588 http://www.doctorfunaus.ora/im aaeban/svnonvms/Doratomvce s.htm Howard p. 588-589 MCM-9, p. 1860 MCM-9, p. 1860 MCM-9, p. 1802, 1828 MCM-9, p. 1881 MCM-9, p. 1898 Howard p. 590-596 Howard p. 590-596 httD://www.doctorfunaus.ora/the funai/exophiala.htm Howard p. 590-596 MCM-9, p. 1898, 1902 MCM-9, p. 1898, 1902 Howard p. 596-597 Howard p. 402 MCM-9, p. 1818 MCM-9, p. 1818 Howard p. 407-409 MCM-9, p. 1818 MCM-9, p. 1818 Howard p. 431 MCM-9, p. 1818 Howard p. 320, 418-421 MCM-9, p. 1818 MCM-9, p. 1818 MCM-9, p. 1818 httD://www.doctorfunaus.ora/the funai/fusarium.htm MCM-9, p. 1818 Rosenzweig et al., 1986 MCM-9, p. 1768, 1770-1771 A33 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Histoplasma capsulatum Hortaea werneckii Lasiodiplodia theobromae Lecythophora hoffmannii Lecythophora mutabilis Leptosphaeria senegalensis Leptosphaeria tompkinsii Loboa loboi Madurella grisea Madurella mycetomatis Malassezia furfur Malassezia globosa Malassezia obtusa Malassezia pachydermatis Malassezia restricta Malassezia sloofiae Malassezia sympodialis Microascus cinereus Microascus cirrosus Microsporum audouinii Microsporum canis Microsporum equinum Microsporum ferrugineum Microsporum fulvum Microsporum gallinae Microsporum gypseum Microsporum nanum Microsporum persicolor Microsporum praecox Microsporum racemosum Microsporum vanbreuseghemii Moniliella suavelolens Synonyms and Notes Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 X X X X X X X 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference MCM-9, p. 1860 MCM-9, p. 1898, 1904 MCM-9, p. 1898, 1904 MCM-9, p. 1802, 1828 MCM-9, p. 1802, 1828 MCM-9, p. 1922 MCM-9, p. 1922 httD://www.doctorfunaus.ora/the funai/Lacazia.htm MCM-9, p. 1922 MCM-9, p. 1922 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1767-1768, 1770- 1771 MCM-9, p. 1802, 1823-1824, 1904 MCM-9, p. 1802, 1823-1824, 1904 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881; Howard p. 170 MCM-9, p. 1881 MCM-9, p. 1881; Howard p. 156, 181 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 httD://www.doctorfunaus.ora/im aaeban/svnonvms/Moniliella.ht m A34 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Mucor circinelloides Mucor hiemalis Mucor indicus Mucor racemosus Mucor ramosissimus Myceliophthora thermophila Mycocentrospora acerina Mycoleptodiscus indicus Myriodontium keratinophilum Nannizzia cajetani Nattrassia mangiferae Neocosmospora vasinfecta Neotestudina rosatii Nigrospora sphaerica Ochroconis gallopava Oidiodendron cerealis Onychocola canadensis Ovadendron ochraceum Ovadendron sulphureo-ochraceum Paecilomyces farinosus Paecilomyces fumerosoreus Paecilomyces javanicus Paecilomyces lilacinus Paecilomyces marquandii Paecilomyces variotii Paecilomyces viridis Paracoccidioides brasiliensis Penicillium chrysogenum Penicillium citrinum Penicillium commune Penicillium decumbens Penicillium dupontii Penicillium expansum Penicillium marneffei Penicillium purpurogenum Phaeoanellomyces elegans Phaeoanellomyces werneckii Synonyms and Notes Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference MCM-9, p. 1839-1840, 1851 MCM-9, p. 1839-1840, 1851 Howard p. 70, 98-99, 101 MCM-9, p. 1839-1840, 1851 MCM-9, p. 1839-1840, 1851 MCM-9, p. 1802, 1828 Howard p. 602-603 Howard p. 602-603 MCM-9, p. 1802, 1828 Howard p. 155 MCM-9, p. 1898, 1904 Howard p. 434-436 MCM-9, p. 1918-1921 httD://www.doctorfunaus.ora/the funai/Niarospora.htm MCM-9, p. 1898, 1902 http://www.doctorfunaus.ora/im aaeban/svnonvms/Oidiodendro n.htm MCM-9, p. 1802, 1828 http://www.cataloaueoflife.ora/s how species details. php?recor d id-3330913 Howard p. 230-232 httD://www.doctorfunaus.ora/the funai/Paecilomvces.htm Howard p. 361-362 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 Howard p. 357-359 MCM-9, p. 1861 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1829 Howard p. 340-346 MCM-9, p. 1802, 1829 MCM-9, p. 1802, 1822 MCM-9, p. 1802, 1829 Howard p. 605-606 MCM-9, p. 1898, 1904 A35 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Phaeosclera dematioides Phaeotrichoconis crotalariae Phialemonium curvatum Phialemonium obovatum Phialophora bubakii Phialophora pedrosoi Phialophora repens Phialophora richardsiae Phialophora verrucosa Phoma cava Phoma cruris-hominis Phoma eupyrena Phoma glomerata Phoma herbarum Phoma hibernica Phoma minutella Phoma oculo-hominis Phyllosticta citricarpa Piedraia hortae Pleurophoma pleurospora Pneumocystis carinii Prototheca wickerhamii Prototheca zopfii Pseudoallescheria boydii Pseudomicrodochium suttonii Pyrenochaeta mackinnonii Pyrenochaeta romeroi Pyrenochaeta unguis-hominis Pythium insidiosum Rhinocladiella aquaspersa Rhinocladiella compacta Rhinocladiella obovoidea Rhinocladiella schulzeri Rhinosporidium seeberi Synonyms and Notes Petrielidium boydii Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 6 X 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference httD://www.doctorfunaus.ora/im aaeban/svnonvms/Phaeosclera .htm Howard p. 606-607 MCM-9, p. 1898, 1900 MCM-9, p. 1898, 1900 Howard p. 607-612 httD://www.doctorfunaus.ora/the funai/Fonsecaea.htm MCM-9, p. 1898, 1902-1903 MCM-9, p. 1898, 1902-1903 MCM-9, p. 1898, 1902-1903 http://www.doctorfunaus.ora/the funai/phoma.htm Howard p. 666-668 Howard p. 666-668 Howard p. 666-668 httD://www.doctorfunaus.ora/the funai/phoma.htm Howard p. 666-668 Howard p. 666-668 Howard p. 666-668 http://www.doctorfunaus.ora/the funai/phoma.htm MCM-9, p. 1891 Howard p. 666-668 MCM-9, p. 1789-1791 MCM-9, p. 1770-1771, 1779 MCM-9, p. 1770-1771, 1779 MCM-9, p. 1922 MCM-9, p. 1898, 1902 MCM-9, p. 1918, 1921-1922 MCM-9, p. 1918, 1921-1922 Howard p. 666-668 MCM-9, p. 1936-1939 MCM-9, p. 1898, 1904 http://www.doctorfunaus.ora/the funai/Fonsecaea.htm http://www.doctorfunaus.ora/im aaeban/svnonvms/Ramichloridi urn. htm http://www.doctorfunaus.ora/im aaeban/svnonvms/Ramichloridi urn. htm MCM-9, p. 1936-1937, 1942- 1943 A36 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Rhizomucor miehei Rhizomucor pusillus Rhizopus azygosporus Rhizopus microsporus Rhizopus oryzae Rhizopus stolonifer Rhodotorula glutinis Rhodotorula minuta Rhodotorula mucilaginosa Rhodotorula rubra Saccharomyces cerevisiae Saksenaea vasiformis Sarcinomyces phaeomuriformis Scedosporium prolificans Schizophyllum commune Scolecobasidium humicola Scolecobasidium tshawytschae Scopulariopsis acremonium Scopulariopsis asperula Scopulariopsis brevicaulis Scopulariopsis brumptii Scopulariopsis Candida Scopulariopsis flava Scopulariopsis fusca Scytalidium hyalinum Scytalidium infestans Setosphaeria rostrata Sporothrix schenckii Sporotrichum pruinosum* Stachybotrys chartarum* Stemphylium macrosporoideum * Stenella araguata Streptomyces somaliensis Taeniolella exilis Taeniolella stilbaspora Tetraploa aristata Thermomyces lanuginosus Synonyms and Notes Nattrassia mangiferae Exserohilum rostratum Note: Streptomyces spp. are bacteria, not fungi Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 5 X X X X 6 7 I 8 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 10 11 | 12 PCCL Reference MCM-9, p. 1839-1840 MCM-9, p. 1839-1840 MCM-9, p. 1839-1840, MCM-9, p. 1839-1840, MCM-9, p. 1839-1840, 1847 MCM-9, p. 1839-1840, MCM-9, p. 1768, 1770-1771 MCM-9, p. 1768, 1770-1771 MCM-9, p. 1768, 1770-1771 MCM-9, p. 1768, 1770-1771 MCM-9, p. 1768, 1770-1771 MCM-9, p. 1839-40, 1850 MCM-9, p. 1898-1902 MCM-9, p. 1821 MCM-9, p. 1802, 1826 Howard p. 617 Howard p. 617 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1823 MCM-9, p. 1904 htto://www. scielo.br/scielo. oho? script=sci arttext&pid=S0036- 46651 999000500009&lna=Dt&n rm=iso&tlna=Dt MCM-9, p. 1900; Palmer, p. 565, 597 MCM-9, p. 1898, 1906 Doggett, 2000 Doggett, 2000 West 1986 httD://www.doctorfunaus.ora/im aaeban/svnonvms/Stenella.htm MCM-9, p. 519-520 Howard p. 621 Howard p. 621 Howard p. 621-623 Howard p. 623 A37 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Fungi Torulopsis magnoliae Trichoderma pseudokoningii Trichoderma viride Trichomaris invadens Trichophyton ajelloi Trichophyton concentricum Trichophyton equinum Trichophyton gallinae Trichophyton gourvilii Trichophyton megninii Trichophyton mentagrophytes Trichophyton rubrum Trichophyton schoenleinii Trichophyton simii Trichophyton soudanense Trichophyton tonsurans Trichophyton verrucosum Trichophyton violaceum Trichosporon asahii Trichosporon beigelii Trichosporon cutaneum Trichosporon inkin Trichosporon mucoides Trichosporon ovoides Tritirachium oryzae Tubercularia vulgaris Ulocladium chartarum Veronaea botryosa Verticillium nigrescens Volutella cinerescens 313 Fungi Synonyms and Notes Screening Criteria Used for Exclusion 1 I 2 | 3 | 4 0 | 0 | 0 | 0 5 12 6 1 7 I 8 0 | 0 9 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 297 10 0 11 | 12 0 | 0 PCCL PCCL = 3 Reference httD://www.doctorfunaus.ora/im aaeban/svnonvms/ToruloDsis.ht m MCM-9, p. 1802, 1828-1829 MCM-9, p. 1802, 1828-1829 http://www.pac.dfo- mpo.ac.ca/sci/shelldis/paaes/ch itfdcb e.htm MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881; Howard p. 173 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1881 MCM-9, p. 1769-1771 MCM-9, p. 1769-1771 MCM-9, p. 1769-1771 MCM-9, p. 1769-1771 MCM-9, p. 1769-1771 MCM-9, p. 1769-1771 http://www.doctorfunaus.ora/im aaeban/svnonvms/Tritirachium. htm Howard p. 448-449 Howard p. 623-624 http://www.doctorfunaus.ora/im aaeban/svnonvms/Veronaea.ht m Howard p. 449-450 Howard p. 451 *Fungi identified by an asterisk were added to the microbial CCL universe by EPA because they were found in biofilm of drinking water distribution sytems in the U.S. MCM-9 refers to the Manual of Clinical Microbiology, 9th Edition \ \ | A38 ------- EPA-OGWDW CCL 3 Microbes: Screening to the PCCL Attachment A: Screening to the PCCL EPA815-R-08-006 February 2008 - DRAFT Summary Pathogen Bacteria Viruses Protozoa1 Helminths Fungi Total Total No. 540 219 66 287 313 1,425 Screening Criteria Used for Exclusion 1 125 0 0 0 0 125 2 14 0 0 0 0 14 3 10 26 1 0 0 37 4 37 104 29 25 0 195 5 117 0 3 0 12 132 6 7 19 0 0 1 27 7 0 1 4 106 0 111 8 29 18 7 0 0 54 9 154 0 7 0 297 458 10 2 36 0 156 0 194 11 28 8 6 0 0 42 12 5 0 0 0 0 5 PCCL No. 12 7 7 0 3 29 1 Cryptosporidium and Giardia are considered to be regulated by LT2. They were not subjected to the screening process, though they were used as examples of contaminants that need to be regulated to validate screening criteria and scoring protocols. These organisms will not be listed on CCL3. A39 ------- |