?/EPA
United States
Environm ental Protection
Agency
O ffice of P revention, P esticddes
and Toxic Substances
(7501C )
Pesticide
Fact Sheet
Nam e of Chem deal: Acequdnocyl
Reason for Issuance: ConddtdonalR egdstzatdon
Date Issued :September26, 2003
1. DESCRIPTION OF CHEM EAL
GenerJcNane:
CcmmonNane:
TiadeNane:
3 -dodecyl-1,4 -dJhydtD-l, 4 -ddoxo-2 -^naphthyl-acetate
Aoaquixxyl
Kanemie
EPA PC Code:
006329
Chan ralAbstracts
CAS) Number:
Year of Ixtial
RegJstratrn:
Pestħħ3eType:
Chan xalFam ity:
Function/1 ode of Action
of
End^U se Product
U S . PJDduOBT:
57960-19-7
2003
M idbife
Quholhe
The m aprm etaboUte of aoaguxiocyl t3eacety]ated
aceguixxy]) iJhJpJtselsctiai tensferbybilling theQo Center
atcom p]ex in ħL the m irxhondrk.
ThJs product ds nota Estrrted use pestidde
A ivesta C ojpDiatdon
2.
USE PATTERNS AND FORM ULAT3DNS
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Applfcatbn Sites:
A cequinocyl is legisteieri foruse on oman entalplants gtow n ii
con m QCBlgtB3ibQusss and soadehouses forconuDlof
varbusmites.
3.
Types of Fom ulatbns: 96 B% tBchnicalpmduct
Use Summary:
15 B
The formuJatedpiDduct; whxh Jsa SDlubte concentiatepmduct
contairing 15 B% aceqirinocylisciDutBiiiwalarandapplHiasafijIL
coveaage foliar ^>iay lvto drp" at 0 D6 t>. aiAOO gallons on joses and
inpatiensandftan 0 D6-0125 ID.aiAOO galbnsonother
ornamentals. The maxinun applfcatbn rate per oDpoycfe Js03 ID.
adA onjDsesandinpadaisandO£ Jb.aiA onotheromanentate.
SuocessTve applications of the pesdcddeaiE not Ecomm ended inoider
to iBduoB any potaital for devetpm entof resistaice.
SCIENCE FMDMGS
A cegudnocyl is a m em ber of the qudnoline cOass of ħis3ctici3es/nħiddes and has beai designated as a
"jBduced risk" pesticide by E PA . The available pmductohen dsby, toxiaology, ecologicaleftects and
envinnmentaliatedata for aceqLrinocyla3ESJTimariz8dbe]cw;a]ong with the escin ated risks to hum an
healh and the envionm entfion itsusecnoinanentalaDpsgiDwnincDmmeKialgi^3ħiausesand
soadehouses:
C hem icalC haracterigdcs
3iJ?SW5(i{;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;tf;t*
''?'i;vJ->*;jiPif5tt^MSIS^^'W*iS>?i?BiiPiiPiiPiiP^
^^^^^K^j^^mSK&ff&f'fif^'i
Color
PhysicalState
Odor
0 xrlaticnyfeirtion
Ffenm ability
E^lodability
Storage Stability
:'t^M>^^^^^^^^^^^^^H
9:iSI^0!^SSmmMM^IiiiSMil
LightBrwn (TGAH)
SoiYelbw (PAD
Flakes (TGAD
Cr/stals (PAD
faintiy earhy (TGAD
non-detectable (PAD
none
nothighy fen m able
notexplosiye
data gap
PaleYelbw
liguid sospensbn
deteagent-like
noieaction
no flashpoint
note^losiye
stable for2 yeais
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'^^^^^^^^^^^^^^^^^^^^^
M TFrririlTly
C onosbn C hatacterisdbs
pH
VJsoosity
Melting Point -TG A I
B oiLing PoJnt-TG A I
Relative density-TG A I
D JssDciaticn constants ii
water-TGAI
Partition coefiEciaibfri-
octano]Aater)-TGA I
W alersDltoDJy; column
elutibnm ethod; shake flask
method-TGAI
V aporpEsane-TG A I
NA
data gap
654 (TGAD
NA
59.6°C
could notbe m eaaitei, TS
changed over200°C
113at20°C
CDold notbe m eaausd, tw
SDliDiBy ii water
]ogPcw 62
ħiwater= 6£9ug^ at20°C
169x10-6 Pa at 25 °C
NA
nan
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pnm aiy dem al
Irritation
not a dem al
sensitizer
B . Subchronic Toxicity D ata
The subchaDni: studies CSS-daydeamalsbjdyandsubchaonic::^^
ibraceguinocylaae sum m arized ħL the tabfe underTaxroDogialEndpoints, bebw .
C . M utagenicity
Aceguinocylwasnotmutagenic: ħL 1) SalnoneDa typhmurium /Esdierichia oolLassay, 2) in VħED
manmalBnceILgaTemutat:bna^^;3) ħivħramammalaicytDgeiTetdbs;and4) amrmnucGeusassay
wihrnousseiytiiiDcytES. OveaH, the data suggest thatacBqirinDcylJsnegati^formutagerddy ħL
VħOD and ii vivo .
D . C aicħiogenr:ħy
C aonogenidy data axe jsquisd for food u^ pesticides and fornonH£xduffipestħħ3eswhenctiinni:
e^x^aiEofhandlersandybrbydandeismayooairasaEa^ofthepe^^ Theu^of
acegirnQcylon gisaibcug^^ entalsJs ejected to EguOtii dioit-and
jnteim ediate^teim nandlerej^osuaE but Js note?^ected to Eaitii dnnni: S^OSUQE to the pesticide.
ThetefoiE, cancerrisk is nota cancem forthis use of aceguinacyl, and caicinogenicity studies aie not
isquiiBd.
T ny imJoqicalE ndpoints
The toxrobgialendpointsusad in the hum an healh risk asaesan entforaceguinocylaiE sum m arced in
the tabtebetw . The identiffed short-team (I - 30 days) dem altoxħo]ogħ3lendpointof 200 m g
aJL^bw/^isbasadupcnixaeasadbDoodc^ The
interned^te-team (I -6 months) dernalendpointisthesaneandisidentifBdftan thessmestudy. A
shore-team (I -30days) inhalationendpoint (30mgaJufcgbw/3ay)wasidentifEdfiom asjbchionic
aat study w heie the effect seal w as isddish urine, w hħh is indicate of the dotting abnoimalitdessaai in
the 28-day deamalstudy. An intern edHtenteam (L-6months) inhalation endpointw as identiffed and
is the ssm e as the shore-team inhaTation endpoint
Sub-C hronic Toxicity Sum m ary and E ndpoint Selectbn for A ceguinocyl
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Shoit-Teim
Damal(L to 30
days)
DamalStudy
NOAEL = 200
mg/fcg/lay
0 ccupatbnalLO C
forM 0 E = 100
28-day D am alToxidty Study in.
theRat
I cbtting factortm es.
literm ediate-
Tam
DamalO-tD6
months)
DamalStLidy
NOAEL = 200
mg/fcg/Say
0 ccupatbnalLO C
forM 0 E = 100
28-day D am alToxidty Study in.
theRat
Increased cbtting factor-tin es.
Short-Tarn
Inhalation (I to
30 days)
Oral study
NOAEL= 30
mg/fcg/Say
Chhalatbn
absorption rate =
100% )
0 ccupatiDnalLO C
forM 0 E = 100
Subħoonħ: fedJng study ħL the
rat
R eddJsh urine observed betw een
week 2 and sacrifice.
Ixasasad pjottnon bħi tin es ħL
males and Jncreasad activated
parcel tincm bqplastin tin es ħL
both sexes.
litamedJate-
Tam lihalatbn
(I to 6 m onths)
Oral study
NOAEL= 30
mg/fcg/Say
(hhalatbn
absorption rate =
100% )
0 ccupatiDnalLO C
forM 0 E = 100
Subchoifc feeding study ħL the
rat
R eddJsh urine cbserved betw een
week 2 and sacrifice.
Ixasasad pjothron bħi tin es ħL
males and Jncreasad activated
partaLthron boplastdn tin es ħL
both sexes.
H um an Exposures and R Jsk:s
A . Residential: No:
ESJdential areas.
itdalexposuoE is expected, shce the pesticide Js not foruse ħL oraound
B . CommercialHandlers: Datafon the PesticideHandlerExposuoEDatabase (PHED) weaeused
to estm ate exposuoE of handlers to acequJnocyL
ShortTerm : TheccmbJnedM atgiiofExposuaE HOE) for the mosthijWy exposed handler
ħL an omam entalgisanhouse setting ^ single JndJviJualw ho m Jxes, Deeds, and apples the
m aterkTsusinghgh-pregguoE,hand-wand equJpm eitj Js3397,whħh JsweHoverthe target
M OE of 100. Based prin any upon the proposed use practices, the A gency expects that,
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typrjally, con m ercialand private fre., grow er) pesticide handlersw illexperieace short-term
exposures 0- - 30 days) . The labeldirects thatsaguentdalacplcadbns should notbem ade.
Intermediate: A Ithough the Agency does nottypicEillyexpectinternediate-tern handler
exposures, the risks estimated for sheet-team exposures aie conservative aind adequate to
pjDtecthandJetswho m ightexpeiiaiae iiteim ediate^term exposures. A s stated above under
ShortTerm , the estin ated exposure and risk to a m ixer/teder/applicatDrusing high pressure,
hand^andeguipmentangieanhouseoinameat^ OE of 100.
C .PostApplicatbn/AgriculiiiralW orkers:
ShortTerm : The transtercoefEcHitdata ficm AgriailtuialRe^ntryTaskFoKe ^RTF)
stuħEsw ae used ii con jjnctħn w ih the appltEnt-subri ited chari ħal-^ecdfc dJsGodgeabte
foliar resndue p PR ) dJsspatbn data fiom chrysanthemunsgiDwnħLagiB3ħiou£e. TheDPR
study evaluated acBguinocyland is metabolite, acBguinocyl-OH t3eacety]ated aceguriocy]) .
The resulting M OE wasgiB3terthan33/)00;CDrectedtD2eflectthe2X maxinum labelrate
used ħL the DFR study. The A gaxy ejects posb-applicatim^riailtLnal
would typralVbe shoifrteim (I -30 days) .M iesaie typically "hotspof &e.; jelatdveV an all
aieas) pests; thetefoie, entie faciffies typxaly nead notbe treated form dtes. A ceguriocyl ds
not to be applied seguentdalV
Interm edJateTerm : A Ihough the Agency does ix5ttypħ3ly e^ectiiteim edJate^tetm handler
exposures, the risks estin ated for shoitteam expcajiesaie conservative and adequate to
pJDtectw outers w ho m ighte^errnce intern edJate-tem e^osutes. The short- and
intern edJate-tem derm aland JnhaladbnendpoħLtsare the same, and do notexceadE PA 's
levelof concem .
E nvironm
The environm entalfate data suppoitiye of the non-food use of aceguiTocyliigiBaihousesand
shadehousesate described below :
A . Hydrolysis: Based on the submitted supplemental study , aceguioocylundagoes rapid hydrolysis
underneutraland alkaline pH mndil-innRand iRmnpndeTPd s^blgiJndgT'act^t^ocrid'it^TiR.npiarFity'latpd
aceguinocylwasiepoited to be them aJDrm etabolite.
B . Aerobic SoilM etabolism : Based on the available study, observed half-lives of degradation in the
sandy loam and sfltspils were less than 2 days.DeacetylatedacBguinocylwasiBpoitedtDbethemaJDr
metabolite.
C . AdsDrptbn/Desorptbn/Leaching: Based on the available studies, aoaguinocyl is expected to
extxbitlow mobility in soiland is expected to exhħ>itlow potential to leach to ground water.
E ooloqicalC haracterigi-ics/R isk
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TheeoologicHleftectedaiacDiTsrlerBd in the qualitative risk asassan entforthepicposaduse ii
giB3nhous33/£hadehous33a2edegcrbe3 below . A quantħativee3o]ogħaIry<:a^e^Tiaitofthe
proposed gieenhouse use is notne3de3,sii3^ thds
indooruse.
A. Birds: ItJsncteqpec^thatthepiqposBduseof
w ould be of concern to biids. B ased on the available acute avian studies, acequinocyl is characterized
as practically non-taxi: to m oderately toxic to bids.
B . Fish: ]t is irotexpectedthatadveise effects to fish w ould iresiiltfrcm the proposed use of
acequinocyl, due to its use indoors aind the i^^ orders of
m agnitude lowerthan the coiKmtratbn atwhxh the toxic effects occur. Additionalacute toxicity
testing is being 2sguestBd;ushg them etabolite iseQf to as^olaii whether the jepoited taxi: eflfectsaie
due to patent, metabolite, orboth. Basai on the Jesuits of the available acute Jħh studies, aceguiiocyl
is chaiacterizBd as sightly (fcom ulated piDduct tested) to m oderatefy technJoalpEDduct tested) toxic to
fieshwater fish, and slght^ (fomulatedprnducttested ) to hħjh]y toxic: (technicalpiDducttested) to
estarine/n arbe fish.
C . A quatic InvertHbrates: Fuilheracute toxicdty testing fiDraquatdc invertebiates isneaded to fuHy
characterize the toxiciy to invertebrates. The additional testing includes (I) testing on eitherdaphnids or
m ysids using deacetylated aceguinocylitea]f to as^olain whether the toxic efltectejepoited are due to
the patent, the deacetylated aceguinocyl, orboth, and 2) testing with the metabolite in a sadment
toxiciy testushgftEshwater invertebrates as the testojganisn . ResuOts of the available acute
freshwater invertebrate study conducted with the fornuJatedpmductshcw aceguinocyltD be sightly
toxr;, and a study using the technicalpJDductshowei lithe
available estuarine/invertebjate studies, both conducted w ith the technicalpmduct, aceguinocylw as
show n to be very highly toxic to the test species.
Addtonal studies are to be conducted on the end^use form ulatibn to fcujher characteri/e its toxiciy to
aquatic invertebrates. To mitigate the risk to aquatic invertebrates during the period that the studies are
in progress, labeling w ilLbe jsguired in connection with the EnvironmentalHazards to advise the user
that the pesticide is very hħjh]y toxic: to invertebrates, such as E astern oysters and mysiishrmp, and
thatdrj&and mnoflEm ay be hazardous to aquatic ojganisTis in waterad^centto treated areas. Ii
addition, the end^use pmductis notexpected to presenta sgnificantrisk to invertebrates, based on its
Dowertoxiciy (stght^toxi:) andthenatLoeoftheuse (indooisinccmmercal
greenhouseSy^Tadehouses).
D . M ammaJs: ]tisnotexpectedthatthe pjoposad use of acegtrinocylwculdJBaLitinexposLireleveils
thatwould be of concern to mammals. M am malen studies show aceguinocyltDbeofverylcw toxiciy
tomammals.
4. SUM M ARY OF REGULATORY POSITION AND RATIONALE
Basad on the available data as described in this doom ent, there is adequate inform atbn to supporta
registration decision underFIFRA sactbnB fc:) (7) C) forthe conditionaljegistration of the pesticide
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pmducts, acegirina^ltBchnicaland the icam ulated prnductdesodoed. in tais docum ent, foruse on
oman entalplantsgtown ii conm eKdalgiearihausesand shadehouses.
U se. Form ulatbn , M anufacturing Process or G eographic R estricriori g
The fomuJatedprnduct falls under the sxpe of the W oikerPmtBction Standatd. fyl PS)andmustbe
uffldon^ħiac!CD2daixewihiB]abelhgand.theW PS,40 CFR partlVO. ThefomuJatedprnduct
label JicLides the W PS Tmrrtbns cited below .
A Estnctecl aiby iitEivalof 12 houts.
The standard. W PS dntESbxtibn of notapplydng ii any w ay thatw ULcontactw outers orother
persons, either discty orthough drift, and the staten entthatonfypjotBctBdwoAetsmaybe
ħL the atea durhg app]ħatħn .
U se of PersDnalPjotBctiye Equpn ent (PPE ) by appHcalois and other-handlers, consisting of
long-slesved shitand long pants, socks, shoes and <ħen ialresistantgloves m ade of
w ateipmof m ateral
The labelbeais the follow Jng addħionalusB Esbħtbn staten ents.
Notforuse ii oraiound restJeritaLsitES. Forusscn^JicommerimLgiBenhousasand
shadehouses.
Restnctions forU se on 0 man entalC rpsG jown ii G jeenhouses:
< Donotapp^thxxghanytypeofirgationsyslHn .
< D o notoontan iate water, food or fed by stoiage ordJsposaL
< DO NOT contamiialewalerwhendJsposiigofegirpmentwashwatErs.
5. SUM M ARY 0 F DATA GAPS
The addldbnaldaia listed below musLbepJDvi3edtotheAgencyascDndħbnsof2^Jstratbn.
Upon Eceptand evaluation of the isguestecl iifom ation, the Agency w ilLieasasss the isgjstration, and,
if appjoprkte, w iTLjen ove these condħbns.
0 ne year storage stability and oonosion chaiactenstics
Skin sensitizatibn study (end^use product)
A dditionaldata to upgtade the aerobi: soiLm etabolisn study
AdditirialdatatDi^giadethehydiDtysisstudy
AdsDJption/SesDJptionstudy
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< FieshwaterJnvertebiate (paphrda) study
< A cute sacLm enttoxidty tesbibr freshw ater Jnvertetaates conducted w jfa the m aprm etabolle
< A cute toxriy to fteshw ater fisa study conducteclw ihthemaJDrmetabDlite
< A cute toxidty to aquatic iiveil^DJHtes study conducted wih the maprmetabDlite
6. CONTACT PERSON AT EPA
M asdihLaws;ChJef
lisacticdde-R odenticite B lanch
RegJstradbnDdydsicn (7505C)
0 ffice of Pesdcife Prngian s
Envionm entalPjotectixL A genoy
A relR JDS B uiihg
1200 Pennsylvania A venue, N W .
W asoiigtDn;DC 20460
0 flFhe Location and Telephone Num her
Room 209,C]ystalMaILBuikiing#2
1921 Jefferson D avdsH ghw ay
AdJngtnn;VA 22202
(703) 308-7038
D EC LA M ER : The Jnfcam adbn piesaitBd ii thJs Pesdidde FactSheet ds foriifom adbnalpuiposas
aa^andm ay notbeusad to fijlffll data isguiiHn ents forpesdcite isgistratJon and leisgjshatbn.
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