United States
Environmental Protection Agency
Office of Prevention, Pesticides and Toxic Substances
(7505P)
&EPA Pesticide
Fact Sheet
Name of Chemical: Chlorantraniliprole
Reason for Issuance: Unconditional
Registration
Date Issued: April 2008
TABLE OF CONTENTS
1. Description of the Chemical [[[ 1
2. Use patterns and Formulations [[[ 2
3. Science Findings [[[ 3
4. Human Health Exposure Assessment ................................................ 9
5. Environmental Exposure and Risk [[[ 11
6. Regulatory Position and Rationale [[[ 29
7. Reduced Risk Classification [[[ 30
8. Contact Person [[[ 31
9. Appendix I: Glossary of Terms and Acronyms .................................... 32
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Chemical Class:
Mode of Action:
Pesticide Type:
U.S. Technical Registrant:
Chemical Structure:
Anthranilic diamide insecticide
Interruption of normal muscle contraction
Insecticide
DuPont Crop Protection
P.O. Box 30
Newark, DEI 9714-0030
2. USE PATTERNS AND FORMULATIONS
Registered Uses:
Pests/Application Sites:
Application Rates:
Types of Formulations/
Product Names:
pome fruit (crop group 11), stone fruit (crop
group 12), leafy vegetables (crop group 4),
Brassica leafy vegetables (crop group 5),
cucurbit vegetables (crop group 9), fruiting
vegetables (crop group 8), cotton, grapes,
potatoes, rice, and ornamentals and turf
grass growing in residential, commercial,
and public landscaped areas
moths, beetles, caterpillars, etc.
Seasonal Maximum:
Food Crops- 0.2 Ib a.i./acre
(rice- 0.13 a.i./acre/year)
Turf Grass- 0.5 Ib a.i./acre
Ornamentals- highly variable, range
between 0.33 to 0.5 Ib
a.i./acre
Technical:
DuPont Rynaxypyr Technical (95.3% a.i.)
End Use (Agricultural Uses):
DuPont Coragen
(18.4% a.i.; suspension concentrate)
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DuPont Altacor
(35% a.i.; water dispersible granule)
End Use (Turf and Ornamental Uses):
DuPont E2Y45 SC Insecticide
(18.4% a.i.; suspension concentrate)
DuPont E2Y45 0.33G Insecticide
(0.33% a.i.; granular)
DuPont E2Y45 0.16G Insecticide
(0.16% a.i.; granular)
DuPont E2Y45 0.133G Insecticide +
Fertilizer
(0.133% a.i.; granular)
Manufacturing Concentrate (35% a.i.)
3. SCIENCE FINDINGS
Physical and Chemical Characteristics:
Available product chemistry data supporting the use of chlorantraniliprole are
summarized below in Tables 1 and 1.1.
Table 1. Chlorantraniliprole Nomenclature.
Chemical structure
Common name
Company experimental name
IUPAC name
CAS name
CAS registry number
a- »-N
Cl
Chlorantraniliprole
DPX-E2Y45
3-Bromo-Af-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-l-(3-chloro-2-
pyridine-2-yl)-lH-pyrazole-5-carboxamide
3-Bromo-A^-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-l-(3-chloro-2-
pyridinyl)-lH-pyrazole-5-carboxamide
500008-45-7
Table 1.1. Physiochemical Properties of the Technical Grade Test
Compound
Parameter
Melting point/range (°C)
pH
Relative Density
Value
200-202 (95.9%)/208 - 210 (99.2%)
5.77 ±0.087 at 20°C
1.5189 (95.9%)/1.507 (99.2%) at 20°C
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Table 1.1. Physiochemical Properties of the Technical Grade Test
Compound
Parameter
Water solubility (20°C)
Solvent solubility (20°C)
Vapor pressure
Dissociation constant, pKa
Octanol/water partition
coefficient, Kow (20°C)
UV/visible absorption (max)
Value
Deionized Water 1.023 mg/L
pH 4 0.972 mg/L
pH 7 0.880 mg/L
pH 9 0.971 mg/L
Acetone 3. 446 ±0.172 g/L
Acetonitrile 0.71 1 ± 0.072 g/L
Ethyl Acetate 1 . 144 ± 0.046 g/L
Dichloromethane 2.476 ± 0.058 g/L
Dimethylformamide 124 ± 4 g/L
n-Octanol 0.386 ± 0.01 g/L
Methanol 1.714 ±0.057 g/L
n-Hexane O.0001 g/L
o-Xylene 0.162 ±0.01 g/L
6.3 x 10'12 Pa @ 20°C, 2. 1 x 10'11 Pa @ 25°C
10.88 ±0.71
Deionized Water 589
pH 4 588
pH7 721
pH 9 654
pH <2 no absorption max >200 nm, at 290 e =
3941
pH 7 no absorption max >200 nm, at 290 e = 4185
pH >10 absorption max at —320 nm which may be
due to decomposition of DPX-E2Y45, at 290 e =
6082
Metabolism Assessment:
The nature of the residue in plants and livestock is adequately understood. Very
little degradation was observed in primary and rotational crops. Unchanged parent
chlorantraniliprole was the major identified residue in primary and rotational crops. The
metabolism of chlorantraniliprole in livestock was extensive and followed the major steps
similar to those observed in rice: (i) hydroxylation of the N-methyl group (to IN-H2H20)
or hydroxylation of the tolyl methyl group (to IN-HXH44); (ii) cyclization with loss of
water to a quinazolinone derivative (IN-EQW78); and (iii) N-demethylation via IN-
H2H20 to IN-F9N04.
Hazard Characterization:
Toxicology Requirements-
The toxicology requirements (40 CFR 158.340) for a food use for
chlorantraniliprole are in Table 2.
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Table 2. Toxicology Data Requirements
Test
Technical
Required
Satisfied
870.1100 Acute Oral Toxicity
870.1200 Acute Dermal Toxicity
870.1300 Acute Inhalation Toxicity
870.2400 Primary Eye Irritation
870.2500 Primary Dermal Irritation
870.2600 Dermal Sensitization
870.3100 Oral Subchronic (rodent)
870.3150 Oral Subchronic (nonrodent)
870.3200 21-Day Dermal
870.3250 90-Day Dermal
870.3465 90-Day Inhalation
870.3700a Developmental Toxicity (rodent)
870.3700b Developmental Toxicity (nonrodent)
870.3800 Reproduction
870.4100a Chronic Toxicity (rodent)
870.4100b Chronic Toxicity (nonrodent)
870.4200a Oncogenicity (rat)
870.4200b Oncogenicity (mouse)
870.4300 Chronic/Oncogenicity
870.5100 Mutagenicity—Gene Mutation - bacterial
870.5300 Mutagenicity—Gene Mutation - mammalian
870.5385 Mutagenicity—Structural Chromosomal Aberrations.
870.5395 Mutagenicity—Micronucleus
870.6100a Acute Delayed Neurotox. (hen)
870.6100b 90-Day Neurotoxicity (hen)
870.6200a Acute Neurotox. Screening Battery (rat)
870.6200b 90-Day Neuro. Screening Battery (rat)
870.6300 Develop. Neuro
870.7485 General Metabolism
870.7600 Dermal Penetration
Special Studies
28-day immunotoxicity (rat)
28-day immunotoxicity (mouse)
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
no
no
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
no
no
yes
yes
no
yes
yes
yes
no
yes
yes
yes
Acute Toxicity -
Chlorantraniliprole Technical is toxicity category IV for all routes of exposure
and is a non-sensitizer (Table 3).
Table 3. Acute Toxicity of Technical Chlorantraniliprole
Guideline
No.
Study Type
MRIDNo.
Results
Toxicity
Category
870.1100
Acute oral toxicity
46889112
LD50 = >5000 mg/kg bw
IV
870.1200
Acute dermal toxicity
46889113
LD50 = >5000 mg/kg bw
IV
870.1300
Acute inhalation
toxicity
46889121
LC50 = >5.1mg/L
IV
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870.2400
870.2500
870.2600
Acute eye irritation
Primary skin irritation
Dermal sensitization
46889115
46889114
46889221
Iritis score of 1 in 1/3 rabbits, conjuctival
redness score of 1 in 2/3 rabbits. All eyes
returned to normal after 72 hours.
No dermal irritation, clinical signs or body
weight loss
Not a dermal sensitizer
IV
IV
Negative
Subchronic, Chronic and Other Toxicity-
In short-term studies, the most consistent effects are those associated with non
adverse pharmacological response to the xenobiotic, induction of liver enzymes and
subsequent increase in liver weights. Chlorantraniliprole is not genotoxic, neurotoxic,
immunotoxic, carcinogenic, or teratogenic. Overall, chlorantraniliprole exhibits minimal
mammalian toxicity after long-term exposure. The only consistent observation in the
mammalian toxicology studies is an increased degree of microvesiculation of the adrenal
cortex after dermal or dietary administration of chlorantraniliprole. Based on the lack of
adverse effect on the function of the adrenal gland, this observation was considered
treatment related, but not "adverse."
Table 4. Subchronic, Chronic and Other Toxicity Profile
STUDY/
SPECIES
14-day Oral
Gavage/ rat
28-Day Oral
(feed)/rat
28-Day Oral
(feed)/mouse
28-day Oral
(capsule)/
Dog
28-day Oral
(feed)/dog -
Palatability
study
28-day
DOSES
(mg/kg/day)
0,25,100,1000
0,20.7, 106 and
584 (male); 0, 24,
128 and 675
(female)
0,52, 182, 538 and
1443 (male); 0, 64,
206, 658 and 1524
(female)
0, 300, 1000
0,26,138,266,
797 and 1302
(male); 0,28, 138,
298, 888, and 1240
(female)
0, 100, 300 and
NOAEL
(mg/kg/day)
1000
584 (male)
and 675
(female)
1443 (male)
and 1524
(female)
1000
1302 (male)
and 1240
(female)
1000
LOAEL
(mg/kg/day)
Not
established
Not
established
Not
established
Not
established
Not
established
Not
EFFECTS
No adverse effects. Weak inducer of cytochrome
P450 3A at all dose levels, with statistical
significance at 100 and 1000 mg/kg/day.
No adverse effects. Slight increase in liver weight
at 128 and 675 mg/kg/day in females and minimal
hepatocellular hypertrophy at 675 mg/kg that is
attributed to enzyme induction characterized by
increased amount of eosinophilic cytoplasm with
hepatocytes but no histomorphologic evidence of
hepatocellular damage. In 128 and 675 mg/kg
females, a statistically significant increase in UDP-
GT activity was observed in HOT female rats, with
a similar increase in males. These changes are
consistent with a pharmacological response and
were not considered adverse.
No adverse effects. Slight increase in liver wt. in
658 and 1524 mg/kg/day females corresponded
with a mild increase in cytochrome P450 enzyme
activity. No histopathological evidence of liver
toxicity was observed.
A reduction in body weight gain was observed in
HDT males (52%) but not in females. No
statistically significant decrease in absolute body
weight was observed therefore, this effect was not
considered adverse.
No adverse effects. Induction of cytochrome P450
enzyme activity (58%) in both males and females at
1000 mg/kg/day, specifically 1A1 and2Bl/2 at 300
and 1000 mg/kg/day.
No adverse effects. Food consumption generally
increased as the study progressed with males
generally demonstrating the highest food
consumption when fed the HDT.
No adverse effects. Reductions in mean body
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Table 4. Subchronic, Chronic and Other Toxicity Profile
STUDY/
SPECIES
Dermal/rat
90-day Oral
(feed)/rat
90-day Oral
(feed)/mouse
90-day Oral
(feed)/dog
52-week
Oral
(feed)/dog
2-Year Oral
(feeding )/rat
18-Month
Oral
(feeding)/
Mouse
Two-
generation
oral
study/rat
DOSES
(mg/kg/day)
1000
0, 36.9, 120, 359,
11 88 (male); 0,47,
157,460,1526
(female)
0,32.6,115,345,
1 135 (male); 0,
40.7,158,422,
1529 (female)
0,32.2,119,303,
1 163 (male); 0,
36.5,133,318,
1220 (female)
0,32,112,317,
11 64 (male); 0,34,
113,278,1233
(female)
0,7.71,39,156,
805 (male); 0,
10.9,51,212,1076
(female)
0,2.6,9.2,26.1,
158, 935 (male); 0,
3.34,11.6,32.9,
196, 1155 (female)
0, 200, 1000,
4000, 20000
ppm,
mg/kg bw/d
NOAEL
(mg/kg/day)
11 88 (male)
and 1526
(female)
11 35 (male)
and 1529
(female)
11 63 (male)
and 1220
(female)
11 64 (male)
and 1233
(female)
805 (male)
and 1076
(female)
158 (male)
and 1155
(female)
11 99 (male)
and 1594
(female)
LOAEL
(mg/kg/day)
established
Not
established
Not
established
Not
established
Not
established
Not
established
935 (male),
no LOAEL
established
for female
Not
established
EFFECTS
weight gain (22% and 19% for males and females)
and food efficiency (19% and 17% for males and
females) over the 28-day at the HDT.
Increased micro vesiculation of adrenal cortex in
males only, with no light or electronic microscopic
evidence of adrenal cellular degeneration or
toxicity. No effect on the capacity of the adrenal
gland to produce corticosterone under either basal
or following ACTH stimulation. Therefore, these
effects were not considered adverse.
No adverse effects. A slight increase in liver
weight at HDT females and reduction in bilirubin
in females at >1 57 mg/kg/day, with no
corresponding histopathological evidence of liver
toxicity.
No adverse effects. Hyperactivity and
hyperreactivity in females were observed near the
end of the study and one male in the upper mid
dose had convulsions, but these effects were
considered spurious as they were not reproducible
in the 1 8-month mouse study with a FOB.
A slight increase in liver weight at the HDT males
and females, with no corresponding
histopathological evidence of liver toxicity.
No adverse effects. A mild increase in liver weight
was observed in males at 1 163 mg/kg/day, with no
corresponding histopathological evidence of liver
toxicity.
No adverse effects. A mild increase in liver weight
in HDT males and females, and increase in alkaline
phosphatase in HDT males, with no corresponding
histopathological evidence of liver toxicity.
Body weight gain increase in HDT males for weeks
8-9 compared to controls, with an increase in food
efficiency in week 9.
No evidence of carcinogenicity and no adverse
findings. Increased adrenal cortical
microvesiculation due to lipid was present in the
zona fasciculata region of the adrenal gland of
some male rats in all dose groups in both the one-
year and main studies. This finding was considered
test substance related but was not considered
adverse as the adrenal morphology was generally in
the range of what was observed in control rats, and
the finding was not associated with any indication
of cytotoxicity or other evidence of structural or
functional impairment of the adrenal gland.
No evidence of carcinogenicity. Eosinophilic foci
accompanied by hepatocellular hypertrophy and
increased liver weight form the bases for the male
LOAEL of 935 mg/kg/day.
A slight increase in mean liver weights in PI
and Fl males and females at 238/3 18.9
mg/kg/day and above, slight increase in mean
adrenal weight at 238/3 18.9 mg/kg/day and
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Table 4. Subchronic, Chronic and Other Toxicity Profile
STUDY/
SPECIES
Develop
mental
study/rat
Develop
mental
study/rabbit
Acute oral
neuro-
toxicity/rat
Subchronic
oral
neuron-
toxicity/rat
28-day
Immuno-
toxicity/rat
28-day
Immuno-
toxicity/
Mouse
DOSES
(mg/kg/day)
equivalents:
pre-mating:
Plm:0, 12,60,
238, 1199
Fl m: 0, 18, 89,
370, 1926
PI f: 0, 16, 78,
318, 1594
Flf:0, 20, 104,
406, 2178
gestation:
PI f: 0, 14, 68,
278, 1373
Flf:0, 14,71,
272, 1465
lactation:
PI f: 0, 32, 162,
654,3118
Flf:0, 35, 183,
696, 3641
0, 20, 100, 300,
1000
0, 20, 100, 300,
1000
0, 200, 700, 2000
in 0.5% methyl
cellulose
0, 12.7, 64.2,
255, 1313
(male);0, 15.1,
77.3, 304, 1586
(female)
0, 74, 363, 1494
(male); 0, 82,
397, 1601
(female)
0,48,264, 1144
(male); 0, 64,
362, 1566
(female)
NOAEL
(mg/kg/day)
1000
1000
2000
13 13 (male)
and 1586
(female)
1494 (male)
and 1601
(female)
1144 (male)
and 1566
(female)
LOAEL
(mg/kg/day)
Not
established
Not
established
Not
established
Not
established
Not
established
Not
established
EFFECTS
1199/1594 mg/kg/day PI andFl males and
females. Mean body weight of 1 199/1594
mg/kg/day Fl pups was slightly reduced on
lactation days 7, 14 and 21. No effects on F2
offspring weights during lactation.
Minimal to mild increase in adrenal cortical
microvesiculation in PI adult males and Fl
adult males and females. PI adult at 60.4/77.8
mg/kg/day and greater. Fl adult males at 12
mg/kg/day and greater. These effects were not
observed in weanlings. No cytotoxicity or
abnormal cellular structures were observed
under light or electron microscopy.
No adverse effects.
No adverse effects.
No evidence of neurotoxicity was observed at
any dose
No evidence of neurotoxicity was observed at
any dose.
No evidence of treatment-related effects on
the sheep red blood cells specific antibody
(IgM) responses in either male or female rats
at any dietary concentration tested.
No evidence of treatment-related effect on the
sheep red blood cells specific antibody (IgM)
responses in either male or female mice at any
dietary concentration tested.
Food Quality Protection Act (FQPA) Decisions:
The Agency concluded that the toxicology database is adequate for Food Quality
Protection Act (FQPA) purposes and that there are no concerns or residual uncertainties
for pre-/post-natal toxicity. Therefore, a FQPA factor of IX was selected. That decision
was based on the following findings:
a. The toxicology database for chlorantraniliprole is complete for the purposes of
this risk assessment and the characterization of potential pre- and postnatal
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risks to infants and children.
b. No susceptibility was identified in the toxicological database, and there are no
residual uncertainties re: pre-and/or postnatal exposure.
c. There are no treatment-related neurotoxic findings in the acute and subchronic
oral neurotoxicity studies in rats.
d. The exposure assessment is protective: the dietary food exposure assessment
utilizes tolerance level residues and 100% crop treated information for all
commodities; the drinking water assessment utilizes values generated by
models and associated modeling parameters which are designed to provide
conservative, health protective, high-end estimates of water concentrations.
By using these screening-level exposure assessments, the chronic dietary
(food and drinking water) risk is not underestimated.
e. Although residential exposure is expected over the short- and possibly
intermediate-term (via the dermal and/or incidental oral route), there is no
hazard expected via these routes/durations, and therefore no risk for these
scenarios.
4. HUMAN HEALTH EXPOSURE AND RISK ASSESSMENT
Residue Profile:
Dietary Exposure and Risk:
Because an endpoint attributable to a single dose was not identified, the dietary
exposure assessment considered only chronic exposure, since chlorantraniliprole was
determined to be toxic only via the chronic oral exposure duration.
Chronic dietary risk assessments were conducted using the Dietary Exposure
Evaluation Model (DEEM-FCID™, Version 2.03) which uses food consumption data
from the U.S. Department of Agriculture's Continuing Surveys of Food Intakes by
Individuals (CSFII) from 1994-1996 and 1998. The chronic assessments assumed that
100% of crops with requested uses of chlorantraniliprole are treated, and that all treated
crops contain residues at tolerance level.
These assumptions result in conservative, health-protective estimates of exposure
which are well below the Agency's level of concern (100% of the cPAD). The maximum
estimate is less than 1% of the cPAD for all population subgroups. These analyses
indicate that there are no dietary exposure considerations that would preclude registration
of chlorantraniliprole for the requested uses.
A drinking water assessment for chlorantraniliprole, conducted based on
PRZM/EXAMS (Pesticide Root Zone Model/Exposure Analysis Modeling System), was
used to calculate the surface water estimated drinking water concentrations (EDWCs) and
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the Screening Concentration in Ground Water (SCI-GROW) model was used to calculate
the groundwater EDWC. The EDWCs do not exceed the Agency's level of concern.
Table 5. Results of Chronic Dietary Exposure and Risk Estimates for
Chlorantraniliprole
Population
Subgroup
U.S. Population
All infants
Children 1 -2 yrs
Children 3 -5 yrs
Children 6-12 yrs
Youth 13-19 yrs
Adults 20-49 yrs
Adults 50+ yrs
Females 13-49 yrs
cPAD,
mg/kg/day
1.58
Chronic Estimates
(Food only)
Exposure,
mg/kg/day
0.007679
0.007856
0.014855
0.012043
0.007999
0.005850
0.007082
0.007613
0.007215
Risk, % cPAD
<1
<1
<1
<1
<1
<1
<1
<1
<1
Chronic Estimates
(Food and Drinking Water)
Exposure,
mg/kg/day
0.007756
0.008108
0.014969
0.012150
0.008073
0.005906
0.007154
0.007689
0.007286
Risk, % cPAD
<1
<1
<1
<1
<1
<1
<1
<1
<1
The population subgroup with the highest estimated exposure/risk is bolded.
Residential Exposure Estimates:
Although there are only two use sites (turfgrass and ornamental plants), as
indicated on the 14 terrestrial non-food end use products, these use sites encompass a
multitude of places that may be treated: home lawns, commercial lawns, industrial
facilities, residential dwellings, business and office complexes, shopping complexes,
multi-family residential complexes, institutional buildings, airports, cemeteries, interior
plantscapes, ornamental gardens, parks, wildlife plantings, playgrounds, schools, daycare
facilities, golf courses, athletic fields, sod farms and other landscaped areas. The
multitude of use sites, in addition to the persistence of Chlorantraniliprole, indicates there
is potential for short- and intermediate-term postapplication dermal (adults and children)
and incidental oral (children only) exposure to Chlorantraniliprole (inhalation exposure is
not expected due to low vapor pressure). However, due to the lack of toxicity over the
acute, short- and intermediate-term via the oral and dermal routes - no risk is expected
from these exposures.
Long-term (greater than 6 months) dermal exposure to turfgrass is not expected
because the use pattern suggests a seasonal window of application, and dislodgeable
foliar residue (DFR) data indicate a maximum half-life of only 30 days on foliage. While
Chlorantraniliprole's persistence in soil (half-life up to 1130 days in dissipation studies on
bareground plots) increases the possibility of long-term exposure for toddlers via
incidental ingestion, the daily quantity of soil a toddler would need to eat to reach the
cPAD is not feasible (more than 4 Ibs/day, even when accounting for accumulation).
Due to the lack of toxicity resulting from Chlorantraniliprole exposure (other than
chronic oral ingestion), spray drift is not expected to pose a risk to residents near spraying
operations.
10
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Aggregate Risk:
Although there is potential exposure to chlorantraniliprole from food, drinking
water and residential use sites, the only identified hazard is via the oral route over a
chronic duration. Residential exposures are expected to occur over a short- or
intermediate-term duration. Therefore, the aggregate risk assessment considers only
exposures from food and drinking water consumed over a long-term duration (greater
than 6 months of daily exposure). That decision was based on the following findings:
a. Acute Risk. No acute risk is expected because no acute hazard,
attributable to a single dose, was identified.
b. Chronic Risk. Using exposure assumptions, we concluded that
exposure to chlorantraniliprole from food and water will utilize <1% of
the cPAD for the population group children 1-2 years (the highest
exposed subpopulation). Based on the use pattern, chronic residential
exposure to residues of chlorantraniliprole is not expected.
c. Short-Term/Intermediate Risk. There is potential for short- and
intermediate-term post-application dermal (adults and children) and
incidental oral (children only) exposure to chlorantraniliprole.
However, due to the lack of toxicity via dermal route, as well as the
lack of toxicity over the acute, short- and intermediate-term via the oral
route - no risk is expected from these exposures. Inhalation exposure
is not expected due to the low vapor pressure of chlorantraniliprole (so
applied/deposited residues are not expected to volatilize into the air).
d. Aggregate Cancer Risk. Chlorantraniliprole has been classified as a
"not likely human carcinogen." It is not expected to pose a cancer risk
to humans.
e. Determination of Safety. Based on the risk assessments, we conclude
that there is a reasonable certainty that no harm will result to the
general population, or to infants and children from aggregate exposure
to chlorantraniliprole residues.
Occupational Exposure:
The chlorantraniliprole toxicology database indicates there is no systemic hazard
associated with short- and intermediate-term dermal and inhalation exposure, and
therefore, no occupational exposure and risk assessment was conducted.
5. ENVIRONMENTAL EXPOSURE AND RISK
Environmental Fate Characteristics:
Chlorantraniliprole may be characterized as persistent and mobile in terrestrial
and aquatic environments. Extended chlorantraniliprole use is expected to cause
11
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accumulation of residues in soil from year to year. Major routes of dissipation are
expected to be alkaline-catalyzed hydrolysis, photodegradation in water, leaching, and
runoff.
Nine degradates/metabolites of the parent compound have been identified in
environmental fate studies: IN-EQW78, IN-LBA22, IN-LBA24, IN-LBA23
IN-ECD73, IN-F6L99, IN-EVK64, IN-F9N04, and IN-GAZ70 (see Table 7). The
greatest percentage production of a degradate was for IN-LB A24, which was 90% of
applied parent produced in the photolysis study at pH7. The risk assessment did not
quantify the risks from these degradates because they were commonly of lower toxic
potency than the parent. For example IN-LB A24 is orders of magnitude less toxic than
the parent pesticide. Coupling the observed lower toxic potency with the risk
assessments exposure modeling assumptions of stability for the parent would suggest that
excluding the degradates from quantitative risk estimation would not substantially affect
the conclusion of the risk assessment.
Table 6. Laboratory Environmental Fate Data for
Chlorantraniliprole
Data
Molecular Weight
Solubility
Vapor Pressure
Henrys Constant
Hydrolysis @ pH 7
Photodegradation in Water
Aerobic Soil Metabolism
Aerobic Aquatic Metabolism
Anaerobic Aquatic
Metabolism
Soil: Water Coefficients (Average
KOC)
Units
g/mole
mg/L
Torr
atm nrVmol
Days
Days
Days
Days
Days
L/g
Value
483.15
1.023
1.57E-13
3.1E-15
Stable
0.31
577.61
537.3
374.6
410.1
246.6
228.0
888.6
924.1
396.0
231
125
208
153 -loam sand
509-silty clay loam
272-sandy loam
526-loamy sand
180-loam
Table 7. Identified Degrades/Metabolites
Study
Hydrolysis
Degradation
Product
IN-EQW78
Maximum Formation
Percentage
(% of applied parent)
86.7 @ pH 9
Chemical Name
(2-[3-Bromo-l-(3-chloro-2-
12
-------
Table 7. Identified Degrades/Metabolites
Study
Photodegradation
in Water
Soil Metabolism
Water/Sediment
Metabolism
Degradation
Product
IN-EQW78
IN-LBA22
IN-LBA24
IN-LBA23
IN-F6L99
IN-EVK64
IN-EQW78
IN-ECD73
INGAZ70
IN-EQW78
IN-F6L99
IN-F9N04
IN-GAZ70
IN-ECD73
Maximum Formation
Percentage
(% of applied parent)
ND @ pH 7 buffer solution
ND @ natural water, sterile
52. 1 @ pH 7 buffer solution
3.4 @ natural water, sterile
90.2 @ pH 7 buffer solution
89.3 @ natural water, sterile
40.8 @ pH 7 buffer solution
51.4 @ natural water, sterile
2.1 @ 25°C incubation
5.2 @ 35°C incubation
4.2 @ 49°C incubation
ND @ 25°C incubation
1.7 @ 3 5°C incubation
5.3 @ 49°C incubation
9.5 @ 25°C incubation
33.3 @ 35°C incubation
71.6 @ 49°C incubation
4.9 @ 25°C incubation
8.2 @ 35°C incubation
9.1 @ 49°C incubation
4.3 @ 25°C incubation
7.4 @ 3 5°C incubation
1.0@49°C incubation
30.2 @ no photodegradation
40.9 @ photodegradation
4.2 @ no photodegradation
ND @ photodegradation
2.7 @ no photodegradation
ND @ photodegradation
3.0 @ no photodegradation
ND @ photodegradation
4.7 @ no photodegradation
0.8 @ photodegradation
Chemical Name
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-3,8 dimethyl-4(3H)-
quinazolinone
(2-[3-Bromo-l-(3-chloro-2-
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-3,8 dimethyl-4(3H)-
quinazolinone
N-Methyl-[3 -bromo- 1H-
pyrazol-5-yl]carboxylic acid
(2-[3-Bromo-l-(3-chloro-2-
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-3,8 dimethyl-4(3H)-
quinazolinone
2-[3-bromo-l-(3-chloro-2-
pyridinyl)- lH-pyrazole-5-yl] -6-
chloro-3,8-dimethyl-4(3H)-
quinazolinone
2-[3-bromo-l-(3-chloro-2-
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-8-methyl-4(lH)-
quinazolinone
(2-[3-Bromo-l-(3-chloro-2-
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-3,8 dimethyl-4(3H)-
quinazolinone
5-bromo-N-methyl-lH-
pyrazole-3-carboxamide
N-[2-(Aminocarbonyl)-4-
chloro-6-methylphenyl]-3-
bromo-l-(3-chloro-2-
pyridinyl) lH-pyrazole-5-
carboxamide
2-[3-bromo-l-(3-chloro-2-
pyridinyl)-lH-pyrazol-5-yl]-6-
chloro-8-methyl-4(lH)-
quinazolinone
2-[3-bromo-l-(3-chloro-2-
pyridinyl)- lH-pyrazole-5-yl] -6-
13
-------
Table 7. Identified Degrades/Metabolites
Study
Degradation
Product
INLBA22
INLBA24
INLNA23
Maximum Formation
Percentage
(% of applied parent)
11. 1 @ no photodegradation
ND @ photodegradation
4.6 @ no photodegradation
1.5 @ photodegradation
2.3 @ no photodegradation
0.5 @ photodegradation
Chemical Name
chloro-3,8-dimethyl-4(3H)-
quinazolinone
Ecological Effects and Risk:
Chlorantraniliprole can be characterized as having very little toxicity to terrestrial
and aquatic vertebrates. As can be expected for an insecticide, the compound is toxic to a
number of terrestrial and aquatic invertebrates. The compound can produce limited
adverse effects in terrestrial and aquatic plants.
Available data for formulated products suggested no concern for enhanced
toxicity of formulations versus the active ingredient alone. Data for degradates suggest
no concern for toxicity exceeding the parent compound and in most cases toxicity is
orders of magnitude below the parent.
Terrestrial Hazard
Birds-
Chlorantraniliprole, degradates and formulated products can be characterized as
being practically non-toxic from the acute oral and dietary perspectives. The available
data show no indications that formulated product, metabolites, or degradates are more
toxic than the active ingredient.
Table 8. Available Bird Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Nature of
Tested
Material
Technical
Technical
Technical
Technical
Registrant
Study ID
DuPont-
14380
DuPont-
14384
DuPont-
14378
DuPont-
14379
Test Species
Anas
platyrhynchos
(Mallard)
Anas
platyrhynchos
(Mallard)
Colinus
virginianus
(Northern
bobwhite)
Colinus
virginianus
(Northern
bobwhite)
Test Type
Subacute
dietary
Reproduction
Acute oral
dose
Subacute
dietary
Endpoint Type
LC50
NOAEC
LOAEC (viable
embryo
reduction)
NOAEC
LD50
NOAEL
LC50
NOAEC)
Effects
Value
Based
onA.S.
>5620
5620
250
500
>2250
2250
>5620
5620
Units of
Active
Substance
mg/kg diet
mg/kg diet
mg/kg bw
mg/kg diet
14
-------
Table 8. Available Bird Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
Technical
IN-EQW78
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Nature of
Tested
Material
Technical
Technical
metabolite
Formulated
Product
Formulated
Product
Formulated
Product
Registrant
Study ID
DuPont-
14383
DuPont-
18859
DuPont-
18945
DuPont-
18946
DuPont-
19420
Test Species
Colinus
virginianus
(Northern
bobwhite)
Colinus
virginianus
(Northern
bobwhite)
Colinus
virginianus
(Northern
bobwhite)
Colinus
virginianus
(Northern
bobwhite)
Colinus
virginianus
(Northern
bobwhite)
Test Type
Reproduction
Acute oral
dose
Acute oral
dose
Acute oral
dose
Subacute
dietary
Endpoint Type
LOAEC
(egsheell
thinning)
NOAEC
LD50
NOAEL
LD50
NOAEL(transient
clinical signs, no
mortality)
LD50
NOAEL(transient
clinical signs, no
mortality)
LC50
NOAEC
Effects
Value
Based
onA.S.
250
120
>2250
2250
>2000
432
>2250
486
>5620
5620
Units of
Active
Substance
mg/kg-diet
mg IN-
EQW78/kg
bw
mg a.i./kg
bw
mg a.i./kg
bw
mg a.i./kg
diet
Mammals-
Acute toxicity study effects for the technical active ingredient in mammals are
reported as follows:
Acute Oral Toxicity LD50: >5000 mg/kg (Rat)
Acute Dermal Toxicity LD50: >5000 mg/kg (Rat)
Acute Inhalation Toxicity LC50: >5.1 mg/L (Rat)
Formulated products are as equally non-toxic following acute exposures as is
technical Chlorantraniliprole. A single dose of Chlorantraniliprole 20SC [200 g/L (w/v);
18.5% (w/w)] (Chlorantraniliprole 20SC) was administered by oral gavage to three fasted
female rats at a dose of 5000 mg/kg. The rats were dosed one at a time at a minimum of
48-hour intervals. All rats survived until the scheduled sacrifice. No clinical signs of
toxicity were observed, and no body weight loss occurred after dosing. No gross lesions
were present in the rats at necropsy. A single dose of Chlorantraniliprole 35WG was
administered by oral gavage to one fasted female rat each at a dose of 175, 550, or 1750
mg/kg and to three fasted female rats at a dose of 5000 mg/kg. No deaths occurred. The
rats exhibited no clinical signs of toxicity during the study. No body weight losses
occurred after dosing. No gross lesions were present in the rats at necropsy. For the
purposes of this risk assessment, to facilitate a comparison of estimated dietary residues
with toxicity endpoints for acute effects, the existing rate oral LD50 toxicity study was
used to estimate a dietary concentration of the pesticide that would correspond to a daily
oral dose equivalent to the LD50. To accomplish this, a conservative ingestion rate of
100 percent of the body weight was applied. The resulting estimated dietary acute
toxicity endpoint is >5000 mg/kg-diet [(>5000 mg/kg-bw)(l kg-bw/lkg-diet) = >5000
mg/kg-diet].
15
-------
In developmental toxicity studies in rats and rabbits, chlorantraniliprole exhibited
no effects on any parameter in pregnant females or their offspring at levels up to and
including the maximum tested dose of 1,000 mg/kg bw/day. The NOAEL for this study
is l,000mg/kg/day.
No reproduction toxicity was observed in a two-generation reproduction study
with chlorantraniliprole in rats. No adverse effects were observed on reproduction,
fertility, sperm parameters, estrous cycle, litter size, pup survival and developmental
landmarks up to the maximum tested dose of 20,000 ppm in the diet. There were no
adverse histological findings indicative of reproductive toxicity. There was a slight
reduction in the Fl pup (but not F2 pup) weight during lactation at the highest dose level
(mean maternal intake during lactation equal to 3118 mg/kg-bw/day); this was attributed,
in part, to weight loss in one dehydrated dam during lactation which had a litter with
some of the lowest pup weights. The slight change in pup weight was without subsequent
effects since overall body weight, weight gain and development in Fl rats fed 20,000
ppm were similar to control animals. The NOAEC for this study is 20,000 ppm or 1000
mg/kg bw/day as a NOAEL (estimated).
Invertebrates-
The available formulated product data, when adjusted for active ingredient
suggest that there is no practical difference between the toxicity of active ingredient and
formulated products to bees.
Table 9. Terrestrial Invertebrate Toxicity Data for Chlorantraniliprole, Formulations,
and Degradates
Test Material
Identification
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
35WG
Chlorantraniliprole
35WG
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Nature of
Tested
Material
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Registrant
Study ID
DuPont-
18423
DuPont-
12405
DuPont-
12753
DuPont-
14387
DuPont*-
14387
DuPont-
14388
DuPont-
14706
DuPont-
16269
DuPont-
16271
DuPont-
16272
DuPont-
17208
DuPont-
17247
Test Species
Aphidius
rhopalosiphi
Aphidius
rhopalosiphi
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Test Type
Mortality
and
reproduction
Mortality
and
reproduction
Semi-field
Acute oral
Acute
contact
semi-field
semi-field
Acute
semi-field
semi-field
semi-field
semi-field
1 ml point
Type
LR50
andER
50
LR50
andER
50
NOEC
LD50
LD50
NOAEC
NOAEC
Mortality
<4%
NOAEC
NOAEC
NOAEC
LOAEC
(mortality
and
decreased
Effects
Value
Based
on A.S.
>750
>750
156.16
>0.119
>0.100
52.5
52.5
112.5
>60
>60
60
>60
Units of Active
Substance
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
mg.
chlorantraniliprole/bee
mg.
chlorantraniliprole/bee
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g chlorantraniliprole/ha
g chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
16
-------
Table 9. Terrestrial Invertebrate Toxicity Data for Chlorantraniliprole, Formulations,
and Degradates
Test Material
Identification
Chlorantraniliprole
20SC
Chlorantraniliprole
Technical
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
IN-EQW78
Chlorantraniliprole
35WG
IN-EQW78
IN-F6L99
IN-ECD73
IN-GAZ70
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Nature of
Tested
Material
Formulated
Product
Technical
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Technical
Technical
metabolite
Formulated
Product
Technical
metabolite
Technical
metabolite
Technical
metabolite
Technical
metabolite
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Registrant
Study ID
DuPont-
17248
DuPont-
17582
DuPont-
18085
DuPont-
18086
DuPont-
18087
DuPont-
18426
DuPont-
17301
DuPont-
19746
DuPont-
17300
DuPont-
14398
DuPont-
15389
DuPont-
16694
DuPont-
17093
DuPont-
17631
DuPont-
17632
DuPont-
17633
DuPont-
18817
DuPont-
18818
DuPont-
16532
DuPont-
18082
DuPont-
19747
Test Species
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Apis mellifera
(Honeybee)
Chrysoperla
carnea
(Green
lacewing)
larvae
Coccinella
septempunctata
(Lady bird
beetle)
Coccinella
septempunctata
(Lady bird
beetle) larvae
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm
Eiseniafetida
(Earthworm
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm)
Eiseniafetida
(Earthworm)
Episyrphus
balteatus
(Hoverfly)
Episyrphus
balteatus
(Hoverfly)
Episyrphus
balteatus
(Hoverfly)
Test Type
semi-field
Acute oral
semi-field
semi-field
semi-field
Acute oral
Mortality
Reproduction
Mortality
Reproduction
Mortality
Reproduction
Acute
Acute
Reproduction
Growth
Reproduction
Growth
Acute
Reproduction
Growth
Reproduction
Growth
Acute
Acute
Mortality
Mortality
Reproduction
Mortality 1st
treatment
Mortality 2ntl
1 ml point
Type
flight
intensity)
LOAEC
(mortality
and
decreased
flight
intensity)
LD50
NOAEC
LOAEC
(mortality
and
decreased
flight
intensity)
NOAEC
LD50
EC50
LOEC
LOAEC
LOAEC
EC50
LOEC
LC50
LC50
NOAEC
NOAEC
LC50
NOAEC
NOAEC
LC50
LC50
LR100
LR50
ER50
control
Effects
Value
Based
on A.S.
60
>0.0274
>104.1
60
60
60
>114.1
120
120
60
60
<120
120
>1000
>1000
350
1000
632.5
1000
1000
>350
>200
120
12.6
13.3
60
60
Units of Active
Substance
g. chlorantraniliprole/ha
ug/bee in water
ug/bee in acetone
chlorantraniliprole/bee
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
jig. chlorantraniliprole/bee
g chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
mg Chlorantraniliprole /kg
soil dry weight.
mg IN-EQW78/kg soil
dry weight.
mg Chlorantraniliprole /kg
soil dry weight.
mg IN-EQW78/kg soil
dry weight.
mg IN-F6L99/kg soil dry
weight.
mg IN-ECD73/kg
artificial soil dry weight
mg IN-GAZ70/kg soil dry
weight
mg chlorantraniliprole/kg
drysoil
mg chlorantraniliprole/kg
drysoil
g chlorantraniliprole/ha
g chlorantraniliprole/ha
G chlorantraniliprole/ha
twice with 7-day interval
17
-------
Table 9. Terrestrial Invertebrate Toxicity Data for Chlorantraniliprole, Formulations,
and Degradates
Test Material
Identification
Chlorantraniliprole
35WG
Chlorantraniliprole
35WG
IN-EQW78
IN-ECD73
Chlorantraniliprole
Chlorantraniliprole
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Nature of
Tested
Material
Formulated
Product
Formulated
Product
Technical
metabolite
Technical
metabolite
Technical
Technical
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Registrant
Study ID
DuPont-
18084
DuPont-
20303
DuPont-
16531
DuPont-
17083
DuPont-
18730
DuPont-
19748
DuPont-
18081
RV1
DuPont-
12406
DuPont-
14704
DuPont-
17312
DuPont-
14705
DuPont-
18424
Test Species
Episyrphus
balteatus
(Hoverfly)
Episyrphus
balteatus
(Hoverfly)
Folsomia
Candida
(Springtail)
Folsomia
Candida
(Springtail)
Folsomia
Candida
(Springtail)
Hypoaspis
aculeifer (mite)
Orius
laevigatus
Typhlodromus
pyri
Typhlodromus
pyri
Typhlodromus
pyri
Typhlodromus
pyri
Typhlodromus
pyri
Test Type
treatment
Reproduction
Mortality
Reproduction
Mortality 1st
treatment
Mortality 2ntl
treatment
Reproduction
Reproduction
Reproduction
Reproduction
Reproduction
Mortality
and
reproduction
Mortality
and
reproduction
Mortality
and
reproduction
Population
study
Population
reduction
(transient)
Mortality
and
reproduction
1 ml point
Type
NOAEL
LR50
ER50
4.4
60
60
60
>100
100
>100
100
0.48
0.39
100
>120
>750
>750
750
52.5
>750
Units of Active
Substance
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
twice with 7-day interval
mg IN-EQW78/kg dry
soil
mg IN-ECD73/kg dry soil
mg Chlorantraniliprole /kg
dry soil
mg Chlorantraniliprole /kg
dry soil
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
g. chlorantraniliprole/ha
Aquatic Hazard-
Freshwater Fish-
While non-definitive LC50 values are only available for Chlorantraniliprole, it can
be characterized as being slightly to practically non-toxic to freshwater fish. The
available data show no indications that formulated products are more toxic than active
ingredient.
Table 10. Freshwater Fish Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Nature of
Tested
Material
Technical
Registrant
Study ID
DuPont-
14278
Test Species
Ictalurus
punctatus
(Channel
Test
Type
Acute
1 ml point
Type
LC50
Effects
Value
Based
on A.S.
>13.4
Units of Active Substance
mg chlorantraniliprole/L
18
-------
Table 10. Freshwater Fish Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Chlorantraniliprole
20SC
Nature of
Tested
Material
Technical
Technical
Technical
Formulated
Product
Formulated
Product
Formulated
Product
Formulated
Product
Registrant
Study ID
DuPont-
12333
DuPont-
12332
DuPont-
14279
DuPont-
15396
DuPont-
18602
DuPont-
15386
DuPont-
18601
Test Species
catfish)
Lepomis
macrochirus
(Bluegill
sunfish)
Oncorhynchus
mykiss
(Rainbow trout)
Oncorhynchus
mykiss
(Rainbow trout)
Lepomis
macrochirus
(Bluegill
sunfish)
Lepomis
macrochirus
(Bluegill
sunfish)
Oncorhynchus
mykiss
(Rainbow trout)
Oncorhynchus
mykiss
(Rainbow trout)
Test
Type
Acute
Acute
Chronic
Acute
Acute
Acute
Acute
1 ml point
Type
LC50
LC50
NOAEC
LC50
LC50
LC50
LC50
Effects
Value
Based
on A.S.
>15.1
>13.8
0.11
>1.19
>1.84
>1.09
>2.16
Units of Active Substance
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/ha
Freshwater Invertebrates-
Chlorantraniliprole can be characterized as very highly toxic to freshwater
invertebrates. The available data show no indications that formulated product,
metabolites, or degradates are more toxic than active ingredient.
Table 11. Freshwater Invertebrate Toxicity Data for Chlorantraniliprole, Formulations,
and Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Nature of
Tested
Material
Technical
Technical
Technical
Technical
Technical
Technical
Technical
Registrant
Study ID
DuPont-
18428
DuPont-
15109
DuPont-
17585
DuPont-
15112
DuPont-
14396
DuPont-
18090
DuPont-
Test Species
Brachionus
calyciflorus
Centroptilum
triangulifer
(Mayfly)
Chimarra
atterima
(Caddisfly)
Chironomus
riparius
(Midge)
Chironomus
riparius
(Midge)
Copepods (of
the suborder
Cyclopoida)
28-day old
Test
Type
Acute
Acute
Acute
Acute
Chronic
Acute
Acute
1 ml point
Type
EC 50
LC50
LC50
LC50
NOAEC
(pore
water
from 28-d
sediment
study
LC50
EC 50
Effects
Value
Based on
A.S.
>1.00
0.0116
0.0117
0.0859
0.005
>1.00
0.0166
Units of Active Substance
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/kg
spiked sediment dry weight
mg Chlorantraniliprole
technical/L
mg chlorantraniliprole/L
19
-------
Table 11. Freshwater Invertebrate Toxicity Data for Chlorantraniliprole, Formulations,
and Degradates
Test Material
Identification
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
LBA24-002
LBA22-002
Chlorantraniliprole
35WG
IN-EQW78
Chlorantraniliprole
Technical
LBA23-000
Chlorantraniliprole
Technical
IN-GAZ70
Chlorantraniliprole
20SC
IN-ECD73
IN-F6L99
IN-F9N04
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Nature of
Tested
Material
Technical
Technical
Technical
metabolite
Technical
metabolite
Formulated
Product
Technical
metabolite
Technical
Technical
Technical
metabolite
Formulated
Product
Technical
metabolite
Technical
metabolite
Technical
metabolite
Technical
Technical
Technical
Technical
Technical
Registrant
Study ID
15868
DuPont-
12411*
DuPont-
12754
RV1
DuPont-
14889
RV1
DuPont-
14890
RV1
DuPont-
15113
DuPont-
15388
DuPont-
15874
DuPont-
16754
RV1
DuPont-
17653
DuPont-
18387
DuPont-
18427
RV1
DuPont-
18472
DuPont-
18473
DuPont-
18474
DuPont-
15877
DuPont-
15114
DuPont-
15873
DuPont-
15872
DuPont-
18804
Test Species
Daphnia magna
(Water flea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Water flea)
Daphnia magna
(Waterflea)
Daphnia magna
(Water flea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Daphnia magna
(Water flea)
Daphnia magna
(Waterflea)
Daphnia magna
(Waterflea)
Gammarus
pseudolimnaeus
Hyalella azteca
Lumbriculus
variegatus
(California
blackworm)
Oronectes virilis
(Crayfish)
Soyedina
carolinensis
(Carolina
Forestfly)
Test
Type
Acute
Chronic
Acute
Acute
Acute
Acute
Chronic
Acute
Acute
Acute
Acute
Acute
Acute
Acute
Acute
Acute
Acute
Acute
Acute
1 ml point
Type
EC 50
NOAEC
EC 50
NOAEC
EC 50
NOAEC
EC 50
EC 50
NOAEC
NOAEC
EC 50
NOAEC
EC 50
EC 50
NOAEC
EC 50
EC 50
NOAEC
EC 50
EC 50
LC50
LC50
LC50
LC50
LC50
Effects
Value
Based on
A.S.
0.0116
0.00447
>10
10
>0.24
0.24
0.011
>0.138
0.138
0.00447
>0.01
0.0098
>0.00987
0.00987
0.0071
>0.013
0.0138
46.8
0.03
0.0351
>0.389
>1.49
>1.42
>0.978
Units of Active Substance
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg LBA24-002/L
mg LBA22-002/L
mg chlorantraniliprole/L
mg IN-EQW78/L
mg chlorantraniliprole/L
mg LBA23-000/L
mg chlorantraniliprole/L
mg IN-GAZ70/L
mg chlorantraniliprole/L
mg IN-ECD73/L
mg IN-F6L99/L
mg IN-F9N04/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
Estuarine/Marine Animals
Estuarine'/Marine Fish-
While non-definitive LC50 values are only available for Chlorantraniliprole, it can
be characterized as being slightly to practically non-toxic to estuarine/marine fish.
Table 12. Estuarine/Marine Fish Toxicity Data for Chlorantraniliprole,
20
-------
Formulations, and Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Nature of
Tested
Material
Technical
Technical
Registrant
Study ID
DuPont-
12334
DuPont-
14394
Test Species
Cyprinodon
variegatus
(Sheepshead
minnow)
Cyprinodon
variegatus
(Sheepshead
minnow)
Test Type
Acute
Early Life
Stage
Toxicity
1 ml point
Type
LC50
NOAEC
Effects
Value
Based on
A.S.
>12.0
1.28
Units of
Active
Substance
mg/L
mg/L
Estuarine/Marine Invertebrates-
Chlorantraniliprole is very highly toxic to certain estuarine marine invertebrates,
based on the data for the eastern oyster. Because the most sensitive species acutely
(oyster) is not represented by chronic values, the acute to chronic ratio for the mysid
(1.15/0.695 = 1.65) was applied to the oyster LC50 to estimate a chronic effects endpoint
for this species (0.0399 mg/L/1.65 = 0.024 mg/L).
Table 13. Estuarine/Marine Invertebrate Toxicity Data for Chlorantraniliprole,
Formulations, and Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Nature of
Tested
Material
Technical
Technical
Technical
Registrant
Study ID
DuPont-
12335
DuPont-
14397
DuPont-
12412
Test Species
Americamysis
bahia
(Mysid shrimp)
Americamysis
bahia
(Mysid shrimp)
Crassostrea
virginica
(Eastern oyster)
Test Type
Acute
Chronic
Acute
Endpoint
Type
LC50
NOAEC
EC 50
Effects
Value
Based
onA.S.
1.15
0.695
0.0399
Units of Active Substance
mg chlorantraniliprole/L
mg chlorantraniliprole/L
mg chlorantraniliprole/L
Plants
Terrestrial Plants-
The following table presents the available terrestrial plant toxicity data.
Table 14. Terrestrial Plant Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
20SC
Nature of
Tested
Material
Formulated
Product
Registrant
Study ID
DuPont-
19074
Test Species
Zea mays
(corn)
Avena sativa
(oat)
Allium cepa
(common
onion)
Lolium
perenne
(perennial
ryegrass)
Test Type
Vegetative
vigor
Endpoint
Type
EC25
dicots
ECS
dicots
Effects Value
Based on A.S.
>300
>300 cucumber,
rape
<300 all others
Units of Active
Substance
g. Chlorantraniliprole
/ha
21
-------
Table 14. Terrestrial Plant Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
20SC
Nature of
Tested
Material
Formulated
Product
Registrant
Study ID
DuPont-
19075
Test Species
Cucumis
saliva
(cucumber)
Brassica
napus (rape)
Pisum sativum
(pea)
Glycine max
(soybean)
Beta vulgaris
(sugarbeet)
Lycopersicon
esculentum
(tomato)
Zea mays
(corn)
Avena sativa
(oat)
Allium cepa
(common
onion)
Lolium
perenne
(perennial
ryegrass)
Cucumis
sativa
(cucumber)
Brassica
napus (rape)
Pisum sativum
(pea)
Glycine max
(soybean)
Beta vulgaris
(sugarbeet)
Lycopersicon
esculentum
(tomato)
Test Type
Seedling
emergence
1 ml point
Type
EC25
monocots
ECS
monocots
EC25
monocots
ECS
monocots
EC25
dicots
ECS
dicots
Effects Value
Based on A.S.
>300
<300 Onion
>300 otherl
species
>300 (except
rygrass with 34%
effect)
<300
<300 all others
>300
<300 (cucumber,
rape, pea, sugar
beet)
>300 otherl
species
Units of Active
Substance
g. Chlorantraniliprole
/ha
Aquatic Plants-
The following table presents the available aquatic plant toxicity data.
Table 15. Aquatic Plant Toxicity Data for Chlorantraniliprole, Formulations, and
Degradates
Test Material
Identification
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
Nature of
Tested
Material
Technical
Technical
Technical
Technical
Registrant
Study ID
DuPont-
14390
DuPont-
12409
RV1
DuPont-
14392
RV1
DuPont-
Test Species
Anabaenaflos-
aquae
(Blue-green algae)
Lemna gibba
(Duckweed)
Navicula
pelliculosa
Selenastrum
Test Type
Growth/
Reproduction
Growth/
Reproduction
Growth/
Reproduction
Growth/
1 ml point
Type
EC50
NOAEC
EC50
NOAEC
EC50
NOEC
EC50
Effects
Value
Based
on
A.S.
>2
2
>2
2
>15.1
15.1
>2
Units of Active
Substance
mg.
chlorantraniliprole/L
mg.
chlorantraniliprole/L
mg.
chlorantraniliprole/L
mg.
22
-------
Technical
Chlorantraniliprole
Technical
Chlorantraniliprole
20SC
Chlorantraniliprole
35WG
Technical
Formulated
Product
Formulated
Product
12408
RV1
DuPont-
14391
DuPont-
18088
DuPont-
18089
capricornutum
(Green algae)
Skeletonema
costatum
P seudokirchneriella
subcapitata
(Green algae)
P seudokirchneriella
subcapitata
(Green algae)
Reproduction
Growth/
Reproduction
Growth/
Reproduction
Growth/
Reproduction
NOEC
EC50
NOEC
EC50
NOEC
EC50
NOEC
2
>14.6
14.6
>4
4
>1.78
1.78
chlorantraniliprole/L
mg.
chlorantraniliprole/L
mg.
chlorantraniliprole/L
mg.
chlorantraniliprole/L
Exposure and Risk to Terrestrial and Aquatic Organisms:
For the purposes of the risk assessment, terrestrial non-target organisms were
assumed to occupy areas immediately adjacent to treatment sites. The exposure
pathways analyzed for terrestrial vertebrate wildlife included dietary uptake of food items
directly treated with the pesticide at the time of application to the treated field.
Exposures were calculated on a dietary basis alone. Dose-based exposures were not
considered due to no evidence of acute oral toxicity. Accumulation from soil to plants or
animal food sources was not considered in this risk assessment. The very low
octanol/water partitioning coefficient (log Kow =2.90) suggested that bioaccumulation is
not likely. Inhalation of vapor phase pesticide was not considered. The low vapor
pressure of the parent compound (6.3 x 10"12 PA) suggested that the pesticide does not
readily volatilize and the rat acute inhalation LC50: >5.1 mg/L suggests that what little
material that would volatilize would not be of significant toxicity. Dermal exposure for
terrestrial vertebrates was not considered quantitatively. The low octanol/water
partitioning coefficient suggested little potential to cross the dermal barrier, a conclusion
supported by the demonstrated low dermal acute toxicity in the rat (LD50: >5000 mg/kg).
Other routes of exposure for terrestrial wildlife that are possible but not
considered include drinking water exposure, inhalation of pesticide associated with
suspended soil paniculate, inhalation of spray droplets, and oral ingestion of soil particles
through incidental contact while feeding and preening.
Terrestrial plant exposures considered potentially complete for this pesticide
include exposure of vegetation adjacent to treatment sites via drift, sheet flow runoff, and
runoff to drainage channels. Drift exposures were considered important to effects
measures involving direct application to leaf surfaces. Drift and runoff exposures were
also comparable to effects endpoints associated with application of pesticide to soil.
Dietary exposures for terrestrial vertebrates were estimated using the T-REX
model version 1.3.1. The exposure endpoint for terrestrial vertebrates from the T-REX
model's output corresponded to an upper bound single day peak concentration of
pesticide in each of four generalized dietary items. These pesticide concentration
estimates were then used for either direct comparison with dietary effects endpoints or
first converted to daily oral dose estimates for feeding wildlife and then compared to
daily dose effects endpoints.
For terrestrial vertebrate risks the T-REX model was used with an assumption of a
maximum 0.5 Ib ai/acre single application rate. This is the highest application rate from
the proposed labels. The assumption of a single maximum application at the labeled crop
23
-------
limit also allowed for consideration of the potential for systemic uptake of the pesticide.
For the purposes of the risk assessment aquatic non-target organisms were assumed
to occupy a surface water body immediately adjacent to treatment sites. The likely
pathways for introduction of the chemical stressor to this aquatic water body include:
• direct deposition of applied product through spray drift
• mass transport of chemical stressor dissolved in run-off from the treated field,
and
• mass transport of chemical stressor adsorbed to eroded solids from the treated
field.
Once pesticide enters the receiving waters, exposure is likely most significant
through absorption of dissolved pesticide from the water column or interstitial water
across the gill, integument, and perhaps the gut of the organism. Food chain exposures
were not considered to be significant for this pesticide because chlorantraniliprole has a
low fish bioconcentration factor of <21.
For estimating exposures of aquatic organisms to chlorantraniliprole, the risk
assessment used the PRZM/EXAMS modeling shell (PE5V01). Inputs for this model are
presented in Table 17. The screening risk assessment used estimates of the dissolved
concentration of the pesticide over a single day, 21-day, and 60-day averaging periods
and the exposure measurement point was that averaging period corresponding to a one in
ten year return frequency for estimating exposure to water column dwelling organisms.
This modeling effort focused on aerial and ground applications only, chemigation and
injection were not included specifically as there was not adequate modeling scenarios. It
is expected that over the top aerial and ground applications are adequate to represent
injection and chemgation. The risk assessment used this approach, although the results
are likely to be overestimates of exposure for such a stable compound as
chlorantraniliprole because the model used up to 36 years of application events.
Table 16. PRZM/EXAMS Input Parameters For
Chlorantraniliprole
Data
Molecular Weight
Solubility
Vapor Pressure
Henrys Constant
Hydrolysis @ pH 7
Photodegradation in
Water
Aerobic Soil Metabolism
Units
g/mole
mg/L
Ton-
aim m3/mol
Days
days
Days
Value
483.15
1.023
1.57E-13
3.1E-15
Stable
0.31
631.762'3
Comments
Calculated via
solubility and vapor
pressure
Calculated 90th
percentile of mean1
Mean= 509 days
SD= 252 days
/=1.40
24
-------
Aerobic Aquatic
Metabolism
Anaerobic Aquatic
Metabolism
SoiLWater Coefficient
(Koc)
Days
Days
L/g
341.13
208
328
n=9
* Several reported
half-lives in MRID
46889124
were not used
because of poor fit
with first-order
degradation model
Calculated 90th
percentile of mean1
Mean= 178 days
SD= 74.95 days
t= 3.078
n=2
Value represents
single half -life value4
Average Koc
Risk to Terrestrial Animals-
Risks of direct effects to terrestrial vertebrates are below Agency screening levels
of concern.
Aquatic to Animals-
Risks of direct effects to freshwater fish and amphibians and estuarine/marine fish
are below Agency screening levels of concern.
Risk to Non-Target Insects-
Terrestrial
Chlorantraniliprole has the potential to produce direct adverse effects in some
non-target terrestrial insect species. It appears from the effects data that sensitivity to the
pesticide is quite varied among tested invertebrates. If species specific risk assessment
becomes necessary (e.g., assessment of a federally listed threatened or endangered
species) it is recommended that closer evaluation of the potential representation of the
invertebrate data set for a specific organism be considered.
Aquatic
Tables 17-18 present the conclusions of the risk assessment for freshwater
invertebrates. Acute concerns are triggered by freshwater invertebrate RQ values for
every exposure scenario modeled (except for ground spray for the Oregon apple and
California turf scenarios, which involve lower rainfall assumptions and thus lower
estimates of aquatic exposure). These concerns are limited primarily to acute effects to
listed species and restricted use considerations.
Chronic freshwater invertebrate risk concerns were identified for proposed uses
on Florida peppers (ground or aerial spray), Florida cucumbers (ground or aerial spray),
25
-------
California nursery (ground spray), Florida nursery (ground spray), and Tennessee nursery
(ground spray). In all cases the RQs were less than an order of magnitude above the
Agency concern level. These chronic endpoints are calculated using the most sensitive
chronic NOEC for daphnids (4.47 ug/L ug/L).
Table 17. Tier II RQs for FW Invertebrates from Aerial Spray Application of DPX-
E2Y45 for Various Crop Types
Scenario
FL cabbage
FL cucumber
PA tomato
CA tomato
FL tomato
FL peppers
CA lettuce
CA cotton
NC cotton
MS cotton
NY grape
CA grape
NC apple
PA apple
OR apple
ID potato
ME potato
GA peach
MI Cherry
Application
Rate
(Ibs/A)
0.065
0.065
0.098
0.098
0.098
0.098
0.065
0.099
0.099
0.099
0.099
0.099
0.099
0.099
0.099
0.066
0.066
0.099
0.099
#
3
3
2
2
2
2
3
2
2
2
2
2
2
2
2
3
3
2
2
Int
(days)
3
5
5
5
5
5
3
5
5
5
7
7
10
10
10
5
5
7
7
Peak
2.652
5.693
1.513
1.080
3.660
6.749
3.579
1.785
3.730
3.769
1.389
1.188
1.359
1.245
0.786
1.021
1.558
1.086
1.035
21-day
Average
2.146
4.939
1.306
0.922
3.001
5.683
2.997
1.576
3.207
3.271
1.197
1.026
1.153
1.091
0.674
0.859
1.392
0.886
0.907
Acute1
RQ
0.1850
0.4258
0.1126
0.0795
0.2587
0.4899
0.2584
0.1359
0.2765
0.2820
0.1032
0.0884
0.0994
0.0941
0.0581
0.0741
0.1200
0.0764
0.0782
Chronic2
RQ
0.4801
1.1049
0.2922
0.2063
0.6714
1.2714
0.6705
0.3526
0.7174
0.7318
0.2678
0.2295
0.2579
0.2441
0.1508
0.1922
0.3114
0.1982
0.2029
Identified
Concerns
RU,LS
RU,LS, Chronic
RU,LS
LS
RU,LS
RU,LS Chronic
RU,LS
RU,LS
RU,LS
RU,LS
RU,LS
LS
LS
LS
LS
LS
RU,LS
LS
LS
1-Acute Toxicity Endpoint= 11.6 ug/L
2-Chronic Toxicity Endpoint= 4.47 ug/L
* RQ = EEC/toxicity endpoint
** Acute RQs compared with acute LOCs fornon listed species (0.5), restricted use (0.1), and listed species (0.05). Chronic RQs compared
with chronic LOG of 1.
Table 18. Tier II RQs for FW Invertebrates from Ground Spray Application ofDPX-
E2Y45 for Various Crop Types
Scenario
FL cabbage
FL cucumber
PA tomato
CA tomato
FL tomato
FL peppers
CA lettuce
CA cotton
NC cotton
MS cotton
NY grape
Application
Rate
(Ibs/A)
0.065
0.065
0.098
0.098
0.098
0.098
0.065
0.099
0.099
0.099
0.099
#
o
J
o
J
2
2
2
2
o
J
2
2
2
2
Int
o
J
5
5
5
5
5
3
5
5
5
7
Peak
2.531
5.624
1.280
0.731
3.436
6.501
3.311
1.470
3.473
3.575
1.189
21-day
Average
2.045
4.86
1.097
0.619
2.817
5.475
2.781
1.28
2.995
3.116
1.025
Acute1
RQ
0.1763
0.4190
0.0946
0.0534
0.2428
0.4720
0.2397
0.1103
0.2582
0.2686
0.0884
Chronic2
RQ
0.4575
1.0872
0.2454
0.1385
0.6302
1.2248
0.6221
0.2864
0.6700
0.6971
0.2293
Identified
Concerns
RU,LS
RU,LS, Chronic
LS
LS
RU,LS
RU,LS, Chronic
RU,LS
RU,LS
RU,LS
RU,LS
LS
26
-------
CA grape
NC apple
PA apple
OR apple
ID potato
ME potato
GA peach
MI Cherry
FLTurf
PA Turf
CATurf
CA Nursery
CA Residential
FL Nursery
MI Nursery
TN Nursery
0.099
0.099
0.099
0.099
0.066
0.066
0.099
0.099
0.26
0.26
0.26
0.4992
0.4992
0.4992
0.4992
0.4992
2
2
2
2
3
3
2
2
2
2
2
1
1
1
1
1
7
10
10
10
5
5
7
7
7
7
7
NA
NA
NA
NA
NA
0.813
0.999
1.048
0.410
0.812
1.350
0.763
0.867
0.837
1.102
0.654
5.663
1.779
9.785
2.508
10.981
0.706
0.852
0.898
0.365
0.68
1.195
0.62
0.739
0.707
0.985
0.554
4.672
1.543
8.136
2.284
9.126
0.0609
0.0734
0.0774
0.0315
0.0586
0.1030
0.0534
0.0637
0.0609
0.0849
0.0478
0.4028
0.1330
0.7014
0.1969
0.7867
0.1579
0.1906
0.2009
0.0817
0.1521
0.2673
0.1387
0.1653
0.1582
0.2204
0.1239
1.0452
0.3452
1.8201
0.5110
2.0416
LS
LS
LS
None
LS
RU,LS
LS
LS
LS
LS
None
RU,LS, Chronic
RU,LS
RU,LS, Chronic
RU,LS
RU,LS, Chronic
l-Acute Toxicity Endpoint=11.6 ug/L
2-Chronic Toxicity Endpoint= 4.47 ug/L
3-(RU) Restricted Use
4-(LS) Listed Species
* RQ = EEC/toxicity endpoint
** Acute RQs compared with acute LOCs fornon listed species (0.5), restricted use (0.1), and listed species (0.05). Chronic RQs compared
with chronic LOG of 1 .
Estuarine/Marine
Risks to estuarine/marine invertebrates that exceed Agency concern levels are
confined to the following Tier II modeling scenarios: Florida cabbage (aerial or ground
spray), Florida cucumber (aerial or ground spray), Florida peppers (aerial or ground
spray), Florida tomatoes (aerial spray), California lettuce (ground and aerial spray),
North Carolina cotton (aerial or ground spray), Mississippi cotton (aerial or ground
spray) California nursery (ground spray), Tennessee nursery (ground spray), Florida
nursery (ground spray), and Mississippi nursery (ground spray). These risks are
generally limited to acute effects to listed species. However, the restricted use LOCs are
exceeded for the Florida vegetable scenarios (cucumber, peppers) and nursery use
scenarios (California nursery, Tennessee nursery, and Florida nursery scenarios).
Table 19. Tier II RQs for Estuarine/Marine Invertebrates from Aerial Spray
Application of DPX-E2Y45 for Various Crop Types
Scenario
FL cabbage
FL cucumber
PA tomato
CA tomato
FL tomato
FL peppers
CA lettuce
CA cotton
NC cotton
MS cotton
NY grape
CA grape
Application
Rate
(Ibs/A)
0.065
0.065
0.098
0.098
0.098
0.098
0.065
0.099
0.099
0.099
0.099
0.099
#
3
3
2
2
2
2
3
2
2
2
2
2
Int
o
J
5
5
5
5
5
3
5
5
5
7
7
Peak
2.652
5.693
1.513
1.080
3.660
6.749
3.579
1.785
3.730
3.769
1.389
1.188
21-day
Average
2.146
4.939
1.306
0.922
3.001
5.683
2.997
1.576
3.207
3.271
1.197
1.026
Acute1
RQ
0.0538
0.1238
0.0327
0.0231
0.0752
0.1424
0.0751
0.0395
0.0804
0.0820
0.0300
0.0257
Chronic2
RQ
0.0894
0.2058
0.0544
0.0384
0.1250
0.2368
0.1249
0.0657
0.1336
0.1363
0.0499
0.0428
Identified
Concerns
LS
RU,LS
None
None
LS
RU,LS
LS
None
LS
LS
None
None
27
-------
NC apple
PA apple
OR apple
ID potato
ME potato
GA peach
MI Cherry
0.099
0.099
0.099
0.066
0.066
0.099
0.099
2
2
2
3
3
2
2
10
10
10
5
5
7
7
1.359
1.245
0.786
1.021
1.558
1.086
1.035
1.153
1.091
0.674
0.859
1.392
0.886
0.907
0.0289
0.0273
0.0169
0.0215
0.0349
0.0222
0.0227
0.0480
0.0455
0.0281
0.0358
0.0580
0.0369
0.0378
None
None
None
None
None
None
None
l-Acute Toxicity Endpoint= 39.9 ug/L
2-Chronic Toxicity Endpoint= 24 ug/L
* RQ = EEC/toxicity endpoint
** Acute RQs compared with acute LOCs fornon listed species (0.5), restricted use (0.1), and listed species (0.05). Chronic RQs compared
with chronic LOG of 1.
Table 20. Tier II RQs for Estuarine/Marine Invertebrates from Ground Spray
Application of DPX-E2Y45 for Various Crop Types
Scenario
FL cabbage
FL cucumber
PA tomato
CA tomato
FL tomato
FL peppers
CA lettuce
CA cotton
NC cotton
MS cotton
NY grape
CA grape
NC apple
PA apple
OR apple
ID potato
ME potato
GA peach
MI Cherry
FLTurf
PA Turf
CATurf
CA Nursery
CA Residential
FL Nursery
MI Nursery
TN Nursery
Application
Rate
(Ib/A)
0.065
0.065
0.098
0.098
0.098
0.098
0.065
0.099
0.099
0.099
0.099
0.099
0.099
0.099
0.099
0.066
0.066
0.099
0.099
0.26
0.26
0.26
0.4992
0.4992
0.4992
0.4992
0.4992
#
o
J
o
J
2
2
2
2
o
J
2
2
2
2
2
2
2
2
o
J
o
J
2
2
2
2
2
Int
o
J
5
5
5
5
5
3
5
5
5
7
7
10
10
10
5
5
7
7
7
7
7
NA
NA
NA
NA
NA
Peak
2.531
5.624
1.280
0.731
3.436
6.501
3.311
1.470
3.473
3.575
1.189
0.813
0.999
1.048
0.410
0.812
1.350
0.763
0.867
0.837
1.102
0.654
5.663
1.779
9.785
2.508
10.981
21-day
Average
2.045
4.86
1.097
0.619
2.817
5.475
2.781
1.28
2.995
3.116
1.025
0.706
0.852
0.898
0.365
0.68
1.195
0.62
0.739
0.707
0.985
0.554
4.672
1.543
8.136
2.284
9.126
Acute1
RQ
0.0513
0.1218
0.0275
0.0155
0.0706
0.1372
0.0697
0.0321
0.0751
0.0781
0.0257
0.0177
0.0214
0.0225
0.0091
0.0170
0.0299
0.0155
0.0185
0.0177
0.0247
0.0139
0.1171
0.0387
0.2039
0.0572
0.2287
Chronic2
RQ
0.0852
0.2025
0.0457
0.0258
0.1174
0.2281
0.1159
0.0533
0.1248
0.1298
0.0427
0.0294
0.0355
0.0374
0.0152
0.0283
0.0498
0.0258
0.0308
0.0295
0.0410
0.0231
0.1947
0.0643
0.3390
0.0952
0.3803
Identified
Concerns
LS
RU,LS
None
None
None
RU,LS
LS
None
LS
LS
None
None
None
None
None
None
None
None
None
None
None
None
RU,LS
None
RU,LS
LS
RU,LS
l-Acute Toxicity Endpoint=39.9 ug/L
2-Chronic Toxicity Endpoint= 24 ug/L
* RQ = EEC/toxicity endpoint
** Acute RQs compared with acute LOCs fornon listed species (0.5), restricted use (0.1), and listed species (0.05). Chronic RQs compared
with chronic LOG of 1.
Risk to Plants-
28
-------
Risks of direct effects to terrestrial and aquatic plants are below Agency screening
levels of concern.
Risk to Endangered Species
The following table summarizes the conclusions of potential concerns for direct
and indirect effects to federally-listed threatened and endangered species (listed species).
Table 21. Potential Effects to Federally Listed Taxa
Listed Taxa
Terrestrial and semi-
aquatic plants -
monocots
Terrestrial and semi-
aquatic plants - dicots
Terrestrial invertebrates
Birds
Terrestrial phase
amphibians
Reptiles
Mammals
Aquatic vascular plants
Freshwater fish
Aquatic phase
amphibians
Freshwater crustaceans
Mollusks
Marine/estuarine fish
Marine/estuarine
invertebrates
Direct
Effects
Yes4
Yes4
Yes
No
No
No
No
No
No
No
Yes
Yes(may be
subject to
further
evaluation)
No
Yes
Scenario Identified as of
Concern
all
All except CA turf
(ground spray) and OR
apple (ground spray)
All except CA turf
(ground spray) and OR
apple (ground spray)
FL cabbage, FL cucumber,
FL pepper, NC cotton, MS
cotton, CA lettuce, CA nursery,
FL nursery, MI nursery, TN
nursery
Indirect
Effects
Yes1
Yes1
No
Yes1'2'3'5
Yes1'2'5
Yes1'2'3'5
Yes1'2'3'5
No
Yes2'5
Yes2'5
Yes2'5
Yes2'5
Yes3
No
Scenario Identified as of
Concern
all
all
All
All
All
All
All
All
All
All
FL cabbage, FL cucumber,
FL pepper, NC cotton, MS
cotton, CA lettuce, CA nursery,
FL nursery, MI nursery, TN
nursery
6. REGULATORY POSITION AND RATIONALE
Available data provide adequate information to support the unconditional
registration of chlorantraniliprole technical and end-use products on crops and turf grass
and ornamentals.
Labeling Restrictions:
29
-------
General Statements-
"Do not apply directly to water. Drift and runoff may be hazardous to aquatic organisms
in water adjacent to use sites."
Surface Water Advisory -
"This product may contaminate water through runoff. This product has a high potential
for runoff for several months or more after application. Poorly draining soils and soils
with shallow water tables are more prone to produce runoff that contains this product. A
level, well-maintained vegetative buffer strip between areas to which this product is
applied and surface water features such as ponds, streams, and springs will reduce the
potential for contamination of water from runoff. Runoff of this product will be reduced
by avoiding applications when rainfall is forecasted to occur within 48 hours."
Ground Water Advisory-
"This chemical has properties and characteristics associated with chemicals detected in
ground water. The use of this chemical in areas where soils are permeable, particularly
where the water table is shallow, may result in ground-water contamination."
Non-Target Organism Advisory-
"This pesticide is toxic to aquatic invertebrates, oysters, and shrimp."
Directions for Use-
Since the residue data for pome fruit reflect spray volumes of 100 gallons per acre, the
use directions for pome fruit should be revised to state "minimum spray volume of 100
gal/A (ground)." Also, as there are inadequate residue data that reflect use of adjuvants
in end-use products in the residue field trials, the proposed labels should be revised to
delete the use of adjuvants on all crops except Brassica crops. In the absence of residue
data on crops grown in greenhouses, the label should prohibit use on crops grown in
greenhouses. Given the results of the confined accumulation and limited field
accumulation in rotational crops study, a restriction should be imposed on the proposed
labels to prohibit the rotation to any crop not on the label.
7. REDUCED RISK CLASSIFICATION
On April 3, 2007, the Reduced Risk Committee categorized chlorantraniliprole as
a "reduced risk" pesticide when used on apple, lettuce, peach, pear, tomato and turf. The
Committee noted that chlorantraniliprole's mammalian toxicity risk profile and
ecotoxicity profile compared favorably with many of the registered alternatives. Since a
reduced risk classification was granted, a public interest finding was not conducted.
Chlorantraniliprole is expected to be a major alternative to azinphos-methyl for
apples and pears. It is also expected to be an alternative to phosmet for these same crops
30
-------
and an alternative to pyrethroids for vegetables.
8. CONTACT PERSON AT EPA
Mailing Address:
Kable Bo Davis, Entomologist
Insecticide-Rodenticide Branch
Registration Division (7505P)
Office of Pesticide Programs
Environmental Protection Agency
1200 Pennsylvania Avenue, N.W.
Washington, DC 20460
Office Location and Telephone Number:
Room S-7225, One Potomac Yard
2777 S. Crystal Drive
Arlington, VA 22202
703-306-0415
DISCLAIMER: The information presented in this Pesticide Fact Sheet is for
informational purposes only may not be used to fulfill data requirements for pesticide
registration and reregi strati on. The information is believed to be accurate as of the date
on the document.
APPENDIX I
GLOSSARY OF TERMS AND ABBREVIATIONS
ADNT Acute delayed neurotoxicity
31
-------
a.i.
aPAD
ARI
BCF
CAS
ChE
ChEI
cPAD
%CT
DAT
DEEM-FCID
DNA
DNT
DIT
DWLOC
EC
EEC
EPA
FQPA
GLC
GLN
LD50
LOAEL
LOAEC
LOC
LOD
LOQ
mg/kg/day
mg/L
MOE
Active Ingredient
Acute Population Adjusted Dose
Aggregate Risk Index
Bioconcentration Factor
Chemical Abstracts Service
Cholinesterase
Cholinesterase inhibition
Chronic Population Adjusted Dose
Percent crop treated
Days after treatment
Dietary Exposure Evaluation Model - Food Consumption Intake
Database
Deoxyribonucleic acid
Developmental neurotoxicity
Developmental immunotoxicity
Drinking Water Level of Comparison.
Emulsifiable Concentrate Formulation
Estimated Environmental Concentration. The estimated pesticide
concentration in an environment, such as a terrestrial ecosystem.
U.S. Environmental Protection Agency
Food Quality Protection Act
Gas Liquid Chromatography
Guideline Number
Median Lethal Concentration. A statistically derived concentration
of a substance that can be expected to cause death in 50% of test
animals. It is usually expressed as the weight of substance per
weight or volume of water, air or feed, e.g., mg/1, mg/kg or ppm.
Median Lethal Dose. A statistically derived single dose that can be
expected to cause death in 50% of the test animals when
administered by the route indicated (oral, dermal, inhalation). It is
expressed as a weight of substance per unit weight of animal, e.g.,
mg/kg.
Lowest Observed Adverse Effect Level
Lowest Observed Adverse Effect Concentration
Level of Concern
Limit of Detection
Limit of Quantitation
Milligram Per Kilogram Per Day
Milligrams Per Liter
Margin of Exposure
32
-------
MRID
MTD
NA
NOEC
NOEL
NOAEL
NOAEC
NPDES
OP
OPP
OPPTS
PAD
PAG
PAM
PHED
PHI
ppb
PPE
ppm
PRZM/EXAMS
RAC
RBC
RED
REI
RfD
SCI-GROW
SF
TGAI
UF
USDA
WPS
Master Record Identification (number), EPA's system of recording
and tracking studies submitted
Maximum tolerated dose
Not Applicable
No Observable Effect Concentration
No Observed Effect Level
No Observed Adverse Effect Level
No Observed Adverse Effect Concentration
National Pollutant Discharge Elimination System
Organophosphate
EPA Office of Pesticide Programs
EPA Office of Prevention, Pesticides and Toxic Substances
Population Adjusted Dose
Pesticide Assessment Guideline
Pesticide Analytical Method
Pesticide Handler's Exposure Data
Preharvest Interval
Parts Per Billion
Personal Protective Equipment
Parts Per Million
Tier II Surface Water Computer Model
Raw Agriculture Commodity
Red Blood Cell
Reregi strati on Eligibility Decision
Restricted Entry Interval
Reference Dose
Tier I Ground Water Computer Model
Safety Factor
Technical Grade Active Ingredient
Uncertainty Factor
micrograms
Micrograms Per Liter
Microliter per gram
United States Department of Agriculture
Worker Protection Standard
33
-------
APPENDIX II
Citations Considered to be Part of the Data Base Supporting the Registration of
Chlorantraniliprole.
46889000 E.I. du Pont de Nemours and Co, Inc. (2006) Submission of Product Chemistry,
Residue, Fate, Environmental Fate and Toxicity Data in Support of the Experiemental
Use of DuPont Coragen SC and DuPont Altacor WG Insecitide Products Containing
DPX-E2Y45 for Use in/on Apples, Celery, Head Lettuce, Leaf Lettuce, Pear, Pepper,
Spinach, Squash, Tomato, and Watermelon and the Petition for Tolerance of DPX-
E2Y45. Transmittal of 35 of 101 Studies.
46889001 Gagnon, M.; Hill, S.; Pentz, A.; et al. (2004) Analytical Method for the Determination
of DPX-E2Y45 and Metabolites in Soil by LC/MS/MS. Project Number:
DUPONT/10814. Unpublished study prepared by E. I. Du Pont De Nemours and Co.,
Inc. 80 p.
46889002 Hill, S.; Stry, J. (2004) Analytical Method for the Determination of DPX-E2Y45 in
Crops Using LC/MS/MS. Project Number: DUPONT/11374. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 47 p.
46889003 Bilas, J.; Gagnon, M.; Stry, J. (2005) Analytical Method for the Determination of DPX-
E2Y45 and Metabolites in Bovine Tissues, Milk, and Eggs Using LC/MS/MS. Project
Number: DUPONT/11376. Unpublished study prepared by DuPont Crop Protection.
80 p.
46889004 MacDonald, A.; Paterson, K.; Coyle, D. (2005) The Metabolism of (Carbon 14)-DPX-
E2Y45 in Apple Trees. Project Number: DUPONT/12264, 804125. Unpublished study
prepared by Inveresk Research International. 126 p.
46889005 MacDonald, A.; Paterson, K.; Coyle, D. (2005) The Metabolism of (Carbon 14)-DPX-
E2Y45 in Lettuce. Project Number: DUPONT/12265, 804172. Unpublished study
prepared by Inveresk Research International. 72 p.
46889006 Macdonald, A.; Gray, J. (2005) The Metabolism of (Carbon 14)-DPX-E2Y45 in
Tomato. Project Number: DUPONT/12266, 804167. Unpublished study prepared by
Inveresk Research International. 91 p.
46889008 Samel, A. (2004) DPX-E2Y45 Technical: Static, Acute, 96-Hour LC50 to Rainbow
Trout, Oncorhynchus mykiss. Project Number: DUPONT/12332, 14513, 228.
Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. 34 p.
46889009 Samel, A. (2004) DPX-E2Y45 Technical: Static, Acute, 96-Hour LC50 to Bluegill
Sunfish, Lepomis macrochirus. Project Number: DUPONT/12333, 14513, 226.
Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. 34 p.
46889010 MacKenzie, S. (2004) DPX-E2Y45 Technical: Subchronic Toxicity 90-Day Feeding
Study in Rats. Project Number: DUPONT/12403, 14513, 1026. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 609 p.
46889011 Samel, A. (2003) DPX-E2Y45 Technical: Static, Acute, 48-Hour EC50 to Daphnia
magna. Project Number: DUPONT/12411, 14513, 241. Unpublished study prepared
by E. I. du Pont de Nemours And Co., Inc. 38 p.
46889012 Luckett, E. (2004) DPX-E2Y45 Technical: 90-Day Oral Toxicity Study in Dogs. Project
Number: DUPONT/12749, 14513, 1319. Unpublished study prepared by MPI
Research, Inc. 916 p.
46889013 Finlay, C. (2006) DPX-E2Y45 Technical: Subchronic Toxicity 90-Day Feeding Study
in Mice. Project Number: DUPONT/12750, 14513, 861. Unpublished study prepared
34
-------
by E. I. du Pont de Nemours And Co., Inc. 456 p.
46889014 McCorquodale, G.; Addison, L. (2005) Aerobic Soil Metabolism of (Carbon 14)-DPX-
E2Y45. Project Number: DUPONT/12779, 804235. Unpublished study prepared by
Inveresk Research International. 118 p.
46889015 McCorquodale, G.; Mackie, D. (2005) (Carbon 14)-DPX-E2Y45: Rate of Degradation
in Three Aerobic Soils. Project Number: DUPONT/12780, 804408. Unpublished study
prepared by Inveresk Research International. 154 p.
46889016 Lynn, R.; McCorquodale, G. (2006) (Carbon 14)-DPX-E2Y45: Degradability and Fate
in the Water/Sediment System. Project Number: DUPONT/12781, 804591.
Unpublished study prepared by Inveresk Research International. 142 p.
46889017 Chapleo, S.; Paterson, K.; White, D. (2004) Hydrolytic Stability of (Carbon 14)-DPX-
E2Y45 in Buffered Aqueous Solutions at pH 4, 7, and 9. Project Number:
DUPONT/12782, 804083. Unpublished study prepared by Inveresk Research
International. 100 p.
46889018 MacDonald, A.; Coyle, D.; Gray, J. (2005) Photodegradation of (Carbon 14)-DPX-
E2Y45 in pH 7 Buffer and Natural Water. Project Number: DUPONT/12783, 804099.
Unpublished study prepared by Inveresk Research International. 121 p.
46889019 Sharma, A.; Rice, F.; Talken, C. (2006) Terrestrial Field Dissipation of Radiolabeled
DPX-E2Y45 Insecticide on Bare Soil in Texas, 2003, USA. Project Number:
DUPONT/12784, 48071. Unpublished study prepared by E. I. du Pont de Nemours
And Co., Inc., Analytical Bio-Chemistry Labs., Incand Dupont Ag Products. 252 p.
46889020 Sharma, A.; Rice, F.; Talken, C. (2005) Terrestrial Field Dissipation of Radiolabeled
DPX-E2Y45 Insecticide on Bare Soil in California, USA. Project Number:
DUPONT/12785, 48131. Unpublished study prepared by E. I. du Pontde Nemours
And Co., Inc., Analytical Bio-Chemistry Labs., Inc and Research for Hire. 160 p.
46889021 Sharma, A.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Texas, 2003, USA. Project Number: DUPONT/12786,
48070. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc.,
Analytical Bio-Chemistry Labs., Incand Dupont Ag Products. 206 p.
46889022 Sharma, A.; Rice, F.; Gant, A. (2005) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in California, 2003, USA. Project Number: DUPONT/12788,
48073. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc.,
Analytical Bio-Chemistry Labs., Inc and Research for Hire. 262 p.
46889023 Sharma, A.; Rice, F.; Gant, A. (2005) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Georgia, 2003, USA. Project Number: DUPONT/12789,
48072. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc.,
Analytical Bio-Chemistry Labs., Inc and Ag Research Associates. 248 p.
46889024 Sharma, A.; Rice, F.; Gant, A. (2005) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in New Jersey, 2003, USA. Project Number:
DUPONT/12790, 48074. Unpublished study prepared by E. I. du Pont de Nemours
And Co., Inc., Analytical Bio-Chemistry Labs., Inc and CMS Inc. 271 p.
46889025 Grant, J. (2006) Stability of DPX-E2Y45 in Representative Crops Stored Frozen.
Project Number: DUPONT/12985, 48387. Unpublished study prepared by Analytical
Bio-Chemistry Labs., Inc. 102 p.
46889026 Craig, W.; Ramsay, N. (2004) DPX-E2Y45: Laboratory Study of Water Solubility.
Project Number: DUPONT/13169, 343385. Unpublished study prepared by Inveresk
Research International. 48 p.
46889027 Huntley, K. (2004) DPX-E2Y45: Spectra (Infrared Spectrum, NMR Spectrum, and
35
-------
Mass Spectrum). Project Number: DUPONT/13170, 48780. Unpublished study
prepared by Analytical Bio-Chemistry Labs., Inc. 21 p.
46889028 Moore, L. (2004) DPX-E2Y45: Oxidizing Properties. Project Number:
DUPONT/13171. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 6 p.
46889029 Hahn, J. (2004) DPX-E2Y45: Stability to Normal and Elevated Temperature, Metal
and Metal Ions. Project Number: DUPONT/13172, 48779. Unpublished study
prepared by ABC Laboratories, Inc. 35 p.
46889030 Craig, W. (2004) DPX-E2Y45: Laboratory Study of Solubility in Organic Solvents.
Project Number: DUPONT/13173, 343579. Unpublished study prepared by Inveresk
Research International. 58 p.
46889031 Craig, W.; Ramsay, N. (2004) DPX-E2Y45: Laboratory Study of pH. Project Number:
DUPONT/13176, 343647. Unpublished study prepared by Inveresk Research
International. 14 p.
46889032 Craig, W. (2004) DPX-E2Y45: Laboratory Study of Partition Coefficient. Project
Number: DUPONT/13177, 343610. Unpublished study prepared by Inveresk
Research International. 41 p.
46889033 Craig, W.; Ramsay, N. (2004) DPX-E2Y45: Laboratory Study of Appearance, Melting
Point and Relative Density. Project Number: DUPONT/13180, 343563. Unpublished
study prepared by Inveresk Research International. 26 p.
46889034 Craig, W.; Clipston, A. (2005) DPX-E2Y45: Laboratory Study of Dissociation
Constant. Project Number: DUPONT/13254, 343605. Unpublished study prepared by
Inveresk Research International. 35 p.
46889035 Kidd, G.; Davidson, J. (2005) DPX-E2Y45: Extraction Efficiency from Lettuce Leaf
and Apple Fruit. Project Number: DUPONT/13260, 206708, 24635. Unpublished
study prepared by Inveresk Research International. 34 p.
46889100 E.I. duPontde Nemours and Co, Inc. (2006) Submission of Fate, Residue, Product
Chemistry and Toxicity Data in Support of the Experimental Use of DuPont Coragen
SC and DuPont AltacorWG Insecitide Products Containing DPX-E2Y45 for Use in/on
Apples, Celery, Head Lettuce, Leaf Lettuce, Pear, Pepper, Spinach, Squash, Tomato,
and Watermelon and the Petition for Tolerance of DPX-E2Y45. Transmittal of 32 of
101 Studies.
46889101 Talken, C.; Sharma, A. (2005) Radiovalidation of the Residues of DPX-E2Y45 and its
Metabolites (IN-EQW78, IN-F6L99, and IN-GAZ70) in Soil. Project Number:
DUPONT/13263, 47925. Unpublished study prepared by Analytical Bio-Chemistry
Labs., Inc. 75 p.
46889102 Rodgers, C.; Grant, J.; Stry, J. (2006) Method Validation for the Analysis of DPX-
E2Y45 in Various Crop Matrices. Project Number: DUPONT/13294, 48342.
Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 140 p.
46889103 Wagner, V.; Atta-Safoh, S. (2004) DPX-E2Y45 Technical: Bacterial Reverse Mutation
Test. Project Number: DUPONT/14127, AA89LE/503/BTL, 15094. Unpublished study
prepared by Bioreliance. 76 p.
46889104 Donner, E. (2006) DPX-E2Y45 Technical: Mouse Bone Marrow Micronucleus Test.
Project Number: DUPONT/14128, 15094, 572. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 66 p.
46889105 Gudi, R.; Rao, M. (2004) DPX-E2Y45 Technical: In Vitro Mammalian Chromosome
Aberration Study in Human Peripheral Block Lymphocytes. Project Number:
DUPONT/14129, AA89LE/341/BTL, 15094. Unpublished study prepared by
36
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Bioreliance. 55 p.
46889106 San, R.; Clarke, J. (2004) DPX-E2Y45 Technical: In Vitro Mammalian Cell Gene
Mutation Test (CHO/HGPRT Test). Project Number: DUPONT/14130,
AA89LE/782/BTL, 15094. Unpublished study prepared by Bioreliance. 46 p.
46889107 Malley, L. (2006) DPX-E2Y45 Technical: Multigeneration Reproduction Study in Rats.
Project Number: DUPONT/14132, 15093, 904. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc., Experimental Pathology Labs., Inc. and North
Carolina State University. 2812 p.
46889108 Malley, L. (2004) DPX-E2Y45 Technical: Developmental Toxicity Study in Rats.
Project Number: DUPONT/14133, 15093, 841. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 188 p.
46889109 Mylchreest, E. (2005) DPX-E2Y45 Technical: Developmental Toxicity Study in
Rabbits. Project Number: DUPONT/14135, 15093, 843. Unpublished study prepared
by E. I. du Pont de Nemours And Co., Inc. 191 p.
46889110 Wang, W. (2006) Validation of the HPLC/UV Analytical Method for DPX-E2Y45 in
DPX-E2Y45 35WG and DPX-E2Y45 200g/L SC (18.4%) End-Use Products. Project
Number: DUPONT/14155, E2Y45/220/03/ST. Unpublished study prepared by E. I. du
Pont de Nemours And Co., Inc. 35 p.
46889111 Hill, S.; Stry, J. (2004) Analytical Method for the Determination of DPX-E2Y45 and
Degradation Products in Crop Process Fractions Using LC/MS/MS. Project Number:
DUPONT/14314. Unpublished study prepared by E. I. du Pont de Nemours and Co.,
Inc. 80 .
46889112 Finlay, C. (2004) DPX-E2Y45 Technical: Acute Oral Toxicity Study in Rodents - Up
and Down Procedure. Project Number: DUPONT/14348, 15207, 834. Unpublished
study prepared by E. I. du Pont de Nemours and Co., Inc. 27 p.
46889113 Finlay, C. (2004) DPX-E2Y45 Technical: Acute Dermal Toxicity Study in Rats. Project
Number: DUPONT/14349, 15207, 673. Unpublished study prepared by E. I. du Pont
de Nemours And Co., Inc. 36 p.
46889114 Finlay, C. (2004) DPX-E2Y45 Technical: Acute Dermal Irritation Study in Rabbits.
Project Number: DUPONT/14350, 15207, 1008. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 22 p.
46889115 Finlay, C. (2004) DPX-E2Y45 Technical: Acute Eye Irritation Study in Rabbits. Project
Number: DUPONT/14352, 15207, 602. Unpublished study prepared by E. I. du Pont
de Nemours And Co., Inc. 22 p.
46889116 McLellan, G.; Vance, C.; Lowrie, C. (2006) Metabolism of (Carbon 14)-DPX-E2Y45 in
the Lactating Goat. Project Number: DUPONT/14377, 805218. Unpublished study
prepared by Charles River Laboratories. 132 p.
46889117 Gallagher, S.; Beavers, J. (2004) DPX-E2Y45 Technical: An Acute Oral Toxicity
Study with the Northern Bobwhite. Project Number: DUPONT/14378, 15210, 112/549.
Unpublished study prepared by Wildlife International, Ltd. 30 p.
46889118 Gallagher, S.; Beavers, J. (2004) DPX-E2Y45 Technical: A Dietary LC50 Study with
the Northern Bobwhite. Project Number: DUPONT/14379, 112/547. Unpublished
study prepared by Wildlife International, Ltd. 43 p.
46889119 Bocksch, S. (2004) DPX-E2Y45 20SC [200g/L (w/v); 18.5% (w/w)]: Acute Oral and
Contact Toxicity to the Honeybee, Apis mellifera L.: Final Report. Project Number:
20041116/S1/BLEU, DUPONT/14386, 15202. Unpublished study prepared by GAB
Biotechnologie Gmbh. 33 p.
37
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46889120 Bocksch, S. (2004) DPX-E2Y45 35WG: Acute Oral and Contact Toxicity to the
Honeybee, Apis Mellifera L: Final Report. Project Number: DUPONT/14387,
20041093/S1/BLEU. Unpublished study prepared by GAB Biotechnologie Gmbh. 32
P-
46889121 Kegelman, T. (2004) DPX-E2Y45 Technical: Inhalation Median Lethal Concentration
(LC50) Study in Rats. Project Number: DUPONT/14399, 15207, 721. Unpublished
study prepared by E. I. du Pont de Nemours And Co., Inc. 45 p.
46889122 Umstatter, S. (2006) (Carbon 14)-DPX-E2Y45: Photodegradation of DPX-E2Y45 in a
Water/Sediment System. Project Number: DUPONT/14438, 97/6265. Unpublished
study prepared by E. I. du Pont de Nemours And Co., Inc. and Springborn Smithers
Laboratories. 120 p.
46889123 Lowrie, C.; Lynn, R.; Coyle, D. (2005) DPX-E2Y45: Batch Equilibrium
(Adsorption/Desorption) in Five Soils. Project Number: DUPONT/14445, 805401.
Unpublished study prepared by Inveresk Research International. 61 p.
46889124 Berg, D.; Singles, S. (2006) Effect of Temperature and SOil Viability on the Rate of
Degradation of (Carbon 14)-DPX-E2Y45 in Two Aerobic Soils. Project Number:
DUPONT/14622. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 154 p.
46889125 Hahn, J. (2006) DPX-E2Y45: Long-Term Storage Stability and Corrosion
Characteristics of the Manufacturing Use Product. Project Number: DUPONT/14636,
49265. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 30 p.
46889126 Syme, G.; Jones, M.; Doran, A. (2006) Validation of an Analytical Method for the
Determination of DPX-E2Y45, in IN-EQW78, IN-F6L99 and IN-GAZ70 in Soil: Report
Amendment No. 1. Project Number: 23691, DUPONT/14819, 303358. Unpublished
study prepared by Inveresk Research International. 283 p.
46889127 Bocksch, S. (2004) DPX-E2Y45 Technical: Acute Contact Toxicity to the Honeybee,
Apis Mellifera L.: Final Report. Project Number: DUPONT/14943, 14513, 344.
Unpublished study prepared by GAB Biotechnologie Gmbh. 26 p.
46889128 Finlay, C. (2006) DPX-E2Y45 Technical: Repeated-Dose Dermal Toxicity 28-Day
Study in Male and Female Rats. Project Number: DUPONT/15745, 15538, 1012.
Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. 235 p.
46889129 Sindermann, A.; Porch, J.; Krueger, H. (2005) DPX-E2Y45 35WG: Foliage Residue
Toxicity Study to the Honey Bee, Apis mellifera L. Project Number: 112/563,
DUPONT/16269, 15749. Unpublished study prepared by Wildlife International, Ltd. 27
P-
46889130 Hatzenbeler, C.; Peterson, B. (2006) DPX-E2Y45: Laboratory Study of Vapor
Pressure. Project Number: DUPONT/16517. Unpublished study prepared by E. I. du
Pont de Nemours And Co., Inc. 39 p.
46889131 Huang, F.; Sharma, A.; Rice, F.; et al. (2006) Terrestrial Field Dissipation of DPX-
E2Y45 Insecticide on Turf in Georgia, 2005, USA. Project Number: DUPONT/16522,
49643. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. and
Analytical Bio-Chemistry Labs., Inc. 246 p.
46889132 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Leafy Vegetables (Head/Leaf Lettuce, Celery, Spinach) Following Foliar Applications
of DPX-E2Y45 20SC [200 g AI/L (w/v); 18.5% (w/w)] - U.S., 2005. Project Number:
DUPONT/16571, 49572. Unpublished study prepared by Analytical Bio-Chemistry
Labs., Inc., ACDS Inc and Welch Agric. Services. 254 p.
46889200 E.I. du Pont de Nemours and Co, Inc. (2006) Submission of Fate, Residue,
38
-------
Environmental Fate, Product Chemistry and Toxicity Data in Support of the
Experimental Use of DuPont Coragen SC and DuPont Altacor WG Insecitide
Products Containing DPX-E2Y45 for Use in/on Apples, Celery, Head Lettuce, Leaf
Lettuce, Pear, Pepper, Spinach, Squash, Tomato, and Watermelon and the Petition
for Tolerance of DPX-E2Y45. Transmittal of 35 of 101 Studies.
46889201 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Cucurbits (Cucumber, Cantaloupe/Muskmelon, Summer Squash) Following Foliar
Applications of DPX-E2Y45 20SC [200 G AI/L(w/v); 18.5% (w/w)] - U.S., 2005.
Project Number: DUPONT/16572, 49571. Unpublished study prepared by Analytical
Bio-Chemistry Labs., Inc, Ag Research Associates and Agriscope, LLC. 184 p.
46889202 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Fruiting Vegetables (Tomato, Bell Pepper, Non-Bell Pepper) Following Foliar
Applications of DPX-E2Y45 20SC [200 G AI/L (w/v); 18.5% (w/v)] - Canada and U.S.,
2005. Project Number: DUPONT/16575, 49569. Unpublished study prepared by
Analytical Bio-Chemistry Labs., Inc, ACDS Research, Inc. and Ashgrow Crop
Management Systems, Inc. 296 p.
46889203 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Pome Fruit (Apple, Pear) Following Foliar Applications of DPX-E2Y45 35WG -
Canada and U.S., 2005. Project Number: DUPONT/16576, 49567. Unpublished study
prepared by Analytical Bio-Chemistry Labs., Inc, ACDS Research, Inc. and CMS Inc.
260 p.
46889206 Finlay, C. (2005) DPX-E2Y45 35WG: Acute Oral Toxicity Study in Rats - Up-and-
Down Procedure. Project Number: DUPONT/16672, 15749, 834. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 27 p.
46889207 Finlay, C. (2005) DPX-E2Y45 35WG: Acute Dermal Toxicity Study in Rats. Project
Number: DUPONT/16674, 15749, 673. Unpublished study prepared by E. I. du Pont
de Nemours And Co., Inc. 35 p.
46889208 Finlay, C. (2005) DPX-E2Y45 35WG: Acute Dermal Irritation Study in Rabbits. Project
Number: DUPONT/16676, 15749, 1008. Unpublished study prepared by E. I. du Pont
de Nemours And Co., Inc. 22 p.
46889209 Finlay, C. (2005) DPX-E2Y45 35WG: Acute Eye Irritation Study in Rabbits. Project
Number: DUPONT/16680, 15749, 602. Unpublished study prepared by E. I. du Pont
de Nemours And Co., Inc. 21 p.
46889210 Bates, M.; Liney, P. (2006) DPX-E2Y45: Laboratory Study of Boiling and
Decomposition Points. Project Number: DUPONT/17044, 0550/102/D2149.
Unpublished study prepared by Covance Laboratories, Ltd. 16 p.
46889211 DeLorme, M. (2006) DPX-E2Y45 35WG: Inhalation Median Lethal Concentration
(LC50) Study in Rats. Project Number: DUPONT/17072, 16049, 721. Unpublished
study prepared by E. I. du Pont de Nemours And Co., Inc. 43 p.
46889212 Umstatter, S.; Peterson, B. (2005) Effect of Temperature on the Hydrolytic Stability of
(Carbon 14)-DPX-E2Y45 in Buffered Aqueous Solution. Project Number:
DUPONT/17456. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 58 p.
46889214 Finlay, C. (2006) DPX-E2Y45 Technical: Repeated-Dose Dermal Toxicity 28-Day
Mechanistic Study in Male Rats. Project Number: DUPONT/17838, 16116, 1012.
Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. 82 p.
46889215 Everds, N. (2006) Development of Methods for the Evaluation of Adrenal Cortical
Function in Rats. Project Number: DUPONT/17987, 16116, 1583. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 60 p.
39
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46889216 Finlay, C. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Acute Oral Toxicity
Study in Rats - Up-and-Down Procedure. Project Number: DUPONT/18063, 16214,
834. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc. 27 p.
46889217 Finlay, C. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Acute Dermal
Toxicity Study in Rats. Project Number: DUPONT/18065, 16214, 673. Unpublished
study prepared by E. I. du Pont de Nemours And Co., Inc. 36 p.
46889218 Finlay, C. (2005) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Acute Dermal
Irritation Study in Rabbits. Project Number: DUPONT/18067, 16214, 1008.
Unpublished study prepared by DuPont Crop Protection. 23 p.
46889219 Finlay, C. (2005) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Acute Eye Irritation
Study in Rabbits. Project Number: DUPONT/18069, 16214, 602. Unpublished study
prepared by DuPont Crop Protection. 22 p.
46889220 Hoban, D. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Local Lymph Node
Assay (LLNA) in Mice. Project Number: DUPONT/18072, 16214, 1234. Unpublished
study prepared by E. I. du Pont de Nemours And Co., Inc. 37 p.
46889221 Hoban, D. (2006) DPX-E2Y45 Technical: Local Lymph Node Assay (LLNA) in Mice.
Project Number: DUPONT/18073, 16067, 1234. Unpublished study prepared byE. I.
du Pont de Nemours And Co., Inc. 35 p.
46889222 Hoban, D. (2005) DPX-E2Y45 35WG: Local Lymph Node Assay (LLNA) in Mice.
Project Number: DUPONT/18074, 16169, 1234. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 37 p.
46889223 DeLorme, M. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Inhalation
Median Lethal Concentration (LC50) Study in Rats. Project Number: DUPONT/18077,
16214, 721. Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc.
48 p.
46889224 Platz, S. (2006) Technical Grade Active Ingredient (DPX-E2Y45) Analysis and
Certification of Product Ingredients in Support of Registration of DPX-E2Y45
Technical. Project Number: DUPONT/18891, E2Y45/220/04/ST. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 242 p.
46889225 Gravell, R. (2006) DPX-E2Y45 Technical Insecticide: Laboratory Study of Explosive
Properties, Flammability of Solids, and the Relative Self-Ignition (Autoflammability)
Temperature. Project Number: DUPONT/19073. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 12 p.
46889226 Bloemer, D. (2006) DPX-E2Y45 35WG Water-Dispersible Granular Insecticide
Formulation: Summary Report of Laboratory Study of Physical and Chemical
Characteristics. Project Number: DUPONT/19257. Unpublished study prepared by E.
I. du Pont de Nemours And Co., Inc. 10 p.
46889227 Bloemer, D. (2006) DPX-E2Y45 18.4SC (200G/Liter) Suspension Concentrate
Insecticide Formulation: Summary Report of Laboratory Study of Physical and
Chemical Characteristics. Project Number: DUPONT/19258. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 10 p.
46889228 Platz, S. (2006) Technical Grade Active Ingredient (DPX-E2Y45) Analysis and
Certification of Toxicological Samples in Support of Registration of DPX-E2Y45
Technical. Project Number: DUPONT/19538. Unpublished study prepared by E. I. du
Pont de Nemours And Co., Inc. 26 p.
46889229 Pugh, L. (2006) Product Identity and Composition of End-Use Product: DPX-E2Y45
35WG. Project Number: DUPONT/20181. Unpublished study prepared by E. I. du
Pont de Nemours And Co., Inc. 56 p.
40
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46889230 Roche, R. (2006) Product Identity and Composition of End-Use Product DPX-E2Y45
200 G/L SC. Project Number: DUPONT/20182. Unpublished study prepared by E. I.
du Pont de Nemours And Co., Inc. 77 p.
46889231 Freudenberger, J. (2006) Technical Grade DPX-E2Y45: Product Identity and
Composition, Materials Used to Produce Product, Production Process and Formation
of Impurities - US EUP. Project Number: DUPONT/20258. Unpublished study
prepared by E. I. du Pont de Nemours And Co., Inc. 89 p.
46889232 Freudenberger, J. (2006) IN-DBC80 (DPX-E2Y45 Intermediate): Materials Used to
Produce, Production Process and Formation of Impurities - US EUP. Project Number:
DUPONT/20259. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 191 p.
46889233 Bentley, K. (2006) DPX-E2Y45: Study Summaries in Support of Experimental Use
Permit in the United States. Project Number: DUPONT/20270. Unpublished study
prepared by E. I. du Pont de Nemours and Co., Inc. 125 p.
46889234 Gaddamidi, V. (2006) DPX-E2Y45: Residue Chemistry: Study Summaries in Support
of Experimental Use Permit in the United States. Project Number: DUPONT/20271.
Unpublished study prepared by E. I. du Pont de Nemours And Co., Inc., Analytical
Bio-Chemistry Labs., Inc and Inveresk Research International. 51 p.
46889235 Singles, S. (2006) DPX-E2Y45: Active Substance: Fate in the Environment. Project
Number: DUPONT/20272. Unpublished study prepared by E. I. du Pont de Nemours
and Co., Inc. 243 p.
46889236 Brugger, K. (2006) DPX-E2Y45: Ecotoxicology. Project Number: DUPONT/20273.
Unpublished study prepared by E. I. du Pont de Nemours, Co., GAB Biotechnologie
and Wildlife International. 34 p.
46889237 Carrig, S. (2006) DPX-E2Y45 Certified Limits for US EUP. Project Number:
DUPONT/20416. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 11 p.
46889238 Wang, W. (2006) Determination of DPX-E2Y45 in DPX-E2Y45 Formulation End-Use
Products - Reversed-Phase Liquid Chromatographic Assay Method. Project Number:
E2Y45/220/03/ST. Unpublished study prepared by E. I. du Pont de Nemours And Co.,
Inc. 24 p.
46895500 E.I. du Pont de Nemours and Co, Inc. (2006) Submission of Residue Data in Support
of the Experiemental Use of DuPont Coragen SC and DuPont Altacor WG Insecitide
Products Containing DPX-E2Y45 for Use in/on Apples, Celery, Cucumber, Head
Lettuce, Leaf Lettuce, Pear, Pepper, Spinach, Squash, Tomato, and Watermelon and
the Petition for Tolerance of DPX-E2Y45. Transmittal of 4 Studies.
46895501 Chapleo, S. (2006) Confined Rotational Crop Study Using (Carbon 14)-DPX-E2Y45.
Project Number: 804214, DUPONT/12314. Unpublished study prepared by Charles
River Laboratories. 179 p.
46895502 Foster, A.; Cairns, S.; Davidson, J.; et al. (2006) Magnitude of DPX-E2Y45, IN-
EQW78, IN-ECD73, and IN-F6L99 Residues in Processed Fractions of Apples (Pome
Fruits) Following Foliar Applications of DPX-E2Y45 20SC [200 G A.S./L (W/V); 18.5%
(W/W)] - Europe, 2005. Project Number: 687674, DUPONT/16587. Unpublished
study prepared by Charles River Laboratories, Agroplan and Viti R&D. 236 p.
46895503 Foster, A; Cairns, S; Davison, J; et al. (2006) Magnitude of DPX-E2Y45, IN-EQW78,
IN-ECD73, and IN-F6L99 Residues in Processed Fractions of Tomatoes (Fruiting
Vegetables, Solanacea) Following Foliar Applications of DPX-EY45 35WG-Europe,
2005. Project Number: 687695, DUPONT/16588. Unpublished study prepared by:
Charles River Laboratories . 242 p.
41
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46895504 Fraser, G; McLellan, G (2006) DPX-E2Y45: Magnitude of Residues of DPX-E2Y45,
IN-HXH44, IN-K9TOO, IN-EQW78, and IN-GAZ70 in Edible Tissues and Milk of
Lactating Dairy Cows Following Dosing with DPX-E2Y45. Project Number: 209578,
DUPONT/17817, 26375. Unpublished study prepared by Charles River Laboratories .
422 p.
46979300 E.I. du Pont de Nemours & Co. (2007) Submission of Product Chemistry, Fate,
Residue, and Toxicity Data in Support of the Applications for Registration of DuPont
Rynaxypyr Technical, DuPont Coragen SC, DuPont AltacorWG, and DuPont E2Y45
SC Insecticides and the Petition for Tolerance of DPX-E2Y45 on Apples, Lettuce,
Peaches, Pears, Tomatoes, Turf, Plum, Cherries, Broccoli, Cauliflower, Mustard
Greens, Cabbage, Cucumber, Squash, Cantaloupe, Bell Pepper, Celery and Spinach.
Transmittal of 50 Studies.
46979301 Boeri, R.; Wyskiel, D.; Ward, T. (2003) DPX-E2Y45 Technical: Static Acute Toxicity to
the Sheepshead Minnow, Cyprinodon variegatus. Project Number: 2595/DU, 14513,
261. Unpublished study prepared by T.R. Wilbury Laboratories, Inc. 35 p.
46979302 Boeri, R.; Wyskiel, D.; Ward, T. (2004) DPX-E2Y45 Technical: Acute Toxicity to the
Mysid, Americamysis bahia. Project Number: DUPONT/12335, 2596/DU, 14513.
Unpublished study prepared by T.R. Wilbury Laboratories, Inc. 36 p.
46979303 Finlay, C. (2003) DPX-E2Y45 Technical: Repeated Dose Oral Toxicity 28-Day
Feeding Study in Mice. Project Number: DUPONT/12404, 14513, 881. Unpublished
study prepared by E. I. du Pont de Nemours and Co, Inc. 283 p.
46979304 Bargen, H. (2003) DPX-E2Y45 35WG: A Laboratory Multiple Dose Test to Study the
Effects on the Parasitoid Aphidius rhopalosiphi (Hymenoptera, Braconidae): Final
Report. Project Number: DUPONT/12405, 20031295/01/NLAP, 14826. Unpublished
study prepared by Arbeitsgemeinschaft GAB Biotechnologie. 38 p.
46979305 Adelberger, I. (2003) DPX-E2Y45 35WG: A Laboratory Multiple Dose Test to Study
the Effects on the Predatory Mite Typhlodromus pyri Scheuten (Acari, Phytoseiidae):
Final Report. Project Number: DUPONT/12406, 20031295/01/NLTP, 14826.
Unpublished study prepared by Arbeitsgemeinschaft GAB Biotechnologie. 34 p.
46979306 Sloman, T (2006) DPX-E2Y45 Technical: Influence on Growth and Growth Rate of
the Green Alga Selenastrum capricornutum. Project Number: DUPONT/12408,
14513, 280. Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 42
P-
46979307 Sloman, T. (2006) DPX-E2Y45 Technical: Influence on Growth and Reproduction of
Lemna gibba G3. Project Number: DUPONT/12409, 14513, 328. Unpublished study
prepared by E. I. Dupont de Nemours and Co, Inc. 39 p.
46979308 Samel, A. (2006) [14-Carbon]-DPX-E2Y45: Bioconcentration in Bluegill Sunfish,
Lepomis macrochirus. Project Number: DUPONT/12410, 15142, 306. Unpublished
study prepared by E. I. du Pont de Nemours and Co, Inc. 86 p.
46979309 Boeri, R.; Wyskiel, D.; Ward, T. (2004) DPX-E2Y45 Technical: Flow-Through Mollusc
Shell Deposition Test Using the Eastern Oyster, Crassostrea virginica. Project
Number: DUPONT/12412, 2597/DU, 14513. Unpublished study prepared by T.R.
Wilbury Laboratories, Inc. 43 p.
46979310 Brown, A.; Young, G.; Holliday, M. (2004) Metabolism of [14-Carbon]-DPX-E2Y45 In
Cotton, Excised and Whole Plant Studies. Project Number: DUPONT/12698.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 56 p.
46979311 Brown, A.; Young, G.; Holliday, M. (2005) [14-Carbon]-DPX-E2Y45 Confined Crop
Rotation Study (Wheat, Soybeans And Radishes). Project Number: DUPONT/12700.
Unpublished study prepared by E.I. du Pont de Nemours and Co, Inc. 62 p.
42
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46979312 Malley, L. (2004) DPX-E2Y45 Technical: Acute Oral Neurotoxicity Study in Rats.
Project Number: DUPONT/12751, 14513, 1261. Unpublished study prepared by E. I.
du Pont de Nemours and Co, Inc. 201 p.
46979313 Kolzer, U. (2006) DPX-E2Y45 20SC: Effects on the Decomposition of Organic Matter
In the Field: Final Report. Project Number: DUPONT/12752, 20031181/F1/NFLB,
14662. Unpublished study prepared by GAB Biotechnologie Gmbh. 55 p.
46979314 Grant, J.; Koch, D. (2005) Crop Rotation Study with DPX-E2Y45 20SC Insecticide-
EPA Cropping Region 6, U.S.A, 2003. Project Number: DUPONT/12775, 48205.
Unpublished study prepared by Analytical Bio-Chemistry Labs, Inc. 95 p.
46979315 Grant, J.; Koch, D. (2005) Crop Rotation Study with DPX-E2Y45 20SC Insecticide -
EPA Cropping Region 5, U.S.A., 2003. Project Number: DUPONT/12777, 48444.
Unpublished study prepared by Analytical Bio-Chemistry Labs, Inc. 108 p.
46979316 Chapleo, S.; Coyle, D. (2004) Photodegradation of [14-Carbon]-DPX-E2Y45 on Soil.
Project Number: DUPONT/12778, 804633. Unpublished study prepared by Inveresk
Research International. 80 p.
46979317 Old, J. (2006) The Field Soil Dissipation Of DPX-E2Y45 Following a single
Application To Bare Ground-Southern Europe. Project Number: DUPONT/12787,
682634, 23709. Unpublished study prepared by Inveresk Research International. 252
P-
46979318 Old, J. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single Application
to Bare Ground - Northern Europe (Burgundy, France). Project Number:
DUPONT/12791, 683271, 24104. Unpublished study prepared by Inveresk Research
International. 252 p.
46979319 Old, J. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single Application
to Bare Ground-Northern Europe (Alsace, France). Project Number: DUPONT/12792,
683287, 24106. Unpublished study prepared by Inveresk Research International. 251
P-
46979320 Old, J. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single Application
to Bare Ground-Southern Europe. Project Number: DUPONT/12793, 683292, 24105.
Unpublished study prepared by Inveresk Research International. 254 p.
46979321 Sharma, A.; Gant, A. (2006) Storage Stability of DPX-E2Y45 and Metabolites (IN-
EQW78, IN-ECD73, and IN-GAZ70) in Frozen Soil. Project Number: DUPONT/12955,
48997. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 105 p.
46979322 Chapleo, S. (1997) High Temperature Hydrolysis of [14-Carbon] -DPX-E2Y45 in
Buffered Aqueous Solution at pH 4, 5, and 6. Project Number: DUPONT/12994,
804240, 23264. Unpublished study prepared by Inveresk Research International. 62
P-
46979323 Addison, L.; McCorquodale, G. (2005) Anaerobic Aquatic Metabolism of [14-Carbon]-
DPX-E2Y45. Project Number: DUPONT/12995, 804612, 24425. Unpublished study
prepared by Inveresk Research International. 98 p.
46979324 Tremain, S. (2004) DPX-E2Y45: Laboratory Study of Vapour Pressure. Project
Number: DUPONT/13168, 1257/002. Unpublished study prepared by Safepharm
Laboratories Ltd. 18 p.
46979326 Rzepka, S. (2005) Validation of Multi-Residue Method DFG S 19 (LOO.00-34) for the
Determination of Residues of DPX-E2Y45 in Different Plant Matrices with LC-MS/MS
Detection. Project Number: 13261, DUP/0503V, AZ/G05/0090. Unpublished study
prepared by Dr. Specht and Partner. 47 p.
46979327 Gagnon, M.; Hill, S.; Stry, J. (2005) Analytical Enforcement Method for the
43
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Determination of DPX-E2Y45 in Crops Using GC-ECD. Project Number: 13291.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 58 p.
46979328 Brookey, F. (2004) Independent Laboratory Validation of the Residue Analytical
Method for DPX-E2Y45 in Various Crops as Described in Dupont-13294. Project
Number: 13292, ML04/1163/DUP. Unpublished study prepared by Morse
Laboratories, Inc. 202 p.
46979329 Singles, S.; Berg, D.; Hatzenbeler, C. (2004) Preparation and Identification of the
Aqueous Photoproducts of DPX-E2Y45. Project Number: 13917. Unpublished study
prepared by E. I. Du Pont De Nemours And Co., Inc. 40 p.
46979330 Himmelstein, M. (2006) [14-Carbon]-DPX-E2Y45: Adsorption, Distribution,
Metabolism and Excretion in Male and Female Rats. Project Number: 14125, 15438,
1017. Unpublished study prepared by E. I. Du Pont De Nemours And Co., Inc. 317 p.
46979331 Himmelstein, M. (2006) [14-Carbon]-DPX-E2Y45: Disposition in Male and Female
Rats During and After Multiple Dose Administration. Project Number: 14126, 15439,
1017. Unpublished study prepared by: E. I. Du Pont De Nemours and Co., Inc. 184 p.
46979332 Foster, A.; Cairns, S. (2005) Decline of DPX-E2Y45 Residues in Wine Grapes
(Berries and Small Fruits) Following Foliar Applications of DPX-E2Y45 20SC - Europe
2004. Project Number: 14139, 684893. Unpublished study prepared by Inveresk
Research International. 61 p.
46979333 Foster, A.; Cairns, S. (2005) Decline of DPX-E2Y45 Residues in Apple Fruit (Pome
Fruit) Following Foliar Applications of DPX-E2Y45 20SC - Europe 2004. Project
Number: 14141, 685368. Unpublished study prepared by Inveresk Research
International. 70 p.
46979334 Foster, A.; Davidson, J.; Cairns, S. (2005) Decline of DPX-E2Y45 Residues in Potato
Tubers Following Foliar Applications of DPX-E2Y45 20SC - Northern Europe 2004.
Project Number: 14143, 685373. Unpublished study prepared by Inveresk Research
International. 59 p.
46979335 Foster, A.; Cairns, S. (2005) Decline of DPX-E2Y45 Residues in Peach Fruit (Stone
Fruit) Following Foliar Applications of DPX-E2Y45 20SC - Southern Europe 2004.
Project Number: 14144, 684935. Unpublished study prepared by Inveresk Research
International. 67 p.
46979336 Carringer, S.; Grant, J. (2005) Decline of DPX-E2Y45 Residues in Potato Tubers
Following Foliar Applications of DPX-E2Y45 35WG - 2004 USA. Project Number:
14149, 48821. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 71
P-
46979337 Foster, A.; Cairns, S. (2005) Decline of DPX-E2Y45 Residues in Field Tomatoes
(Solanacea Vegetables) Following Foliar Applications of DPX-E2Y45 35WG -
Southern Europe 2004. Project Number: 14153, 684940. Unpublished study prepared
by Inveresk Research International. 66 p.
46979338 Foster, A.; Cairns, S.; Davidson, J. (2005) Decline of DPX-E2Y45 Residues in
Protected Tomatoes (Solanacea Vegetables) Following Foliar Applications of DPX-
E2Y45 35WG - Southern Europe 2004. Project Number: 14154, 684956. Unpublished
study prepared by Inveresk Research International. 67 p.
46979339 Turner, J. (2004) DPX-E2Y45 Technical: Static, Acute, 96-Hour Limit Test to Channel
Catfish, Ictalurus punctatus. Project Number: 14278, 15142, 227. Unpublished study
prepared by E. I. Du Pont de Nemours and Co. Inc. 34 p.
46979340 Samel, A. (2004) DPX-E2Y45 Technical: Early-Life-Stage Toxicity to Rainbow Trout,
Oncorhynchus mykiss. Project Number: 14279, 15142, 217. Unpublished study
44
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prepared by E. I. Du Pont de Nemours and Co., Inc. 127 p.
46979341 Hill, S.; Stry, J.; Bilas, J. (2005) Analytical Method for the Determination of DPX-
E2Y45 and Degradation Products in Crop Process Fractions Using LC/MS/MS.
Project Number: 14314. Unpublished study prepared by E. I. Du Pontde Nemours
and Co., Inc. 29 p.
46979342 Moore, G. (2004) DPX-E2Y45 Technical: Dermal Sensitization Magnusson-Kligman
Maximization Method. Unpublished study prepared by Product Safety Laboratories.
31 p.
46979343 Munley, S. (2006) DPX-E2Y45 Technical: 28-Day Immunotoxicity Feeding Study in
Rats. Project Number: 14353, 15207, 1545. Unpublished study prepared by E. I. Du
Pont de Nemours and Co., Inc. 75 p.
46979344 Munley, S. (2006) DPX-E2Y45 Technical: 28-Day Immunotoxicity Feeding Study in
Mice. Project Number: 14354, 15207, 1546. Unpublished study prepared by E. I. Du
Pont de Nemours and Co., Inc. 78 p.
46979345 Gallagher, S.; Beavers, J. (2004) DPX-E2Y45 Technical: A Dietary LC50 Study with
the Mallard. Project Number: 14380, 15210, 1620. Unpublished study prepared by
Wildlife International, Ltd. 44 p.
46979346 Schur, A. (2005) DPX-E2Y45 20SC : A Semi-Field Study to Evaluate Effects on the
Honey Bee (Apis mellifera mellifera; Hymenoptera, Apidae) in Phacelia in Spain
2004. Project Number: 20041116/S1/BZEU, 14388, 15202. Unpublished study
prepared by GAB Biotechnologie Gmbh. 46 p.
46979347 Kolzer, U. (2004) DPX-E2Y45 Technical: Assessment of the Effects on Soil
Microflora. Project Number: 20041090/01/ABMF, 14389, 15206. Unpublished study
prepared by GAB Biotechnologie Gmbh. 41 p.
46979348 Sloman, T. (2004) DPX-E2Y45 Technical: Influence on Growth and Growth Rate of
the Blue-Green Alga Anabena flos-aquae. Project Number: 14390, 15142, 324.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 37 p.
46979349 Ward, T.; Wyskiel, D.; Boeri, R. (2004) DPX-E2Y45 Technical: Influence on Growth
and Growth Rate of the Marine Diatom, Skeletonema costatum. Project Number:
2736/DU, 14391, 15142. Unpublished study prepared by T.R. Wilbury Laboratories,
Inc. 33 p.
46979350 Ward, T.; Boeri, R.; Wyskiel, D. (2004) DPX-E2Y45 Technical: Flow-Through Early
Life Stage Toxicity to the Sheepshead Minnow, Cyprinodon variegatus. Project
Number: 2739/DU, 14394, 15142. Unpublished study prepared by T.R. Wilbury
Laboratories, Inc. 54 p.
46979400 E.I. du Pont de Nemours and Co., Inc. (2007) Submission of Toxicity, Environmental
Fate, Residue, Efficacy, Fate, and Product Chemistry Data in Support of the
Applications for Registration of DuPont Rynaxypyr Technical, DuPont Coragen SC
Insecticide, DuPont Altacor WG Insecticide, DuPont E2Y45 SC Insecticide, and the
Petition for Tolerance of DPX-E2Y45 on Apples, Lettuce, Peaches, Pears, Tomatoes,
Turf, Plum, Cherries, Broccoli, Cauliflower, Mustard Greens, Cabbage, Cucumber,
Squash, Cantaloupe, Bell Pepper, Celery and Spinach. Transmittal of 50 Studies.
46979401 Ward, T.; Boeri, R.; Wyskiel, D. (2004) DPX-E2Y45 Technical: Flow-Through Chronic
Toxicity to the Mysid, Americamysis bahia. Project Number: 2738/DU,
DUPONT/14397, 15142. Unpublished study prepared by T.R. Wilbury Laboratories,
Inc. 50 p.
46979402 Luhrs, U. (2004) DPX-E2Y45 Technical: Acute Toxicity to the Earthworm, Eisenia
fetida in Artificial Soil: Final Report. Project Number: 20421021, DUPONT/14398,
45
-------
15206. Unpublished study prepared by Institut fuer Biologische Analytik und
Consulting IBACON. 25 p.
46979403 Sharma, A.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Washington, 2004, USA. Project Number:
DUPONT/14439, 48927. Unpublished study prepared by Analytical Bio-Chemistry
Labs., Inc and E. I. du Pont de Nemours and Co., Inc. 232 p.
46979404 Sharma, A.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil Minnesota, 2005, USA [Interim Report]. Project Number:
DUPONT/14440, 48925. Unpublished study prepared by Analytical Bio-Chemistry
Labs., Inc and E. I. du Pont de Nemours and Co., Inc. 70 p.
46979405 Duncan, P. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single
Application to Bare Ground - Southern Europe (Spain). Project Number:
DUPONT/14441, 684694, 24120. Unpublished study prepared by Charles River
Laboratories. 195 p.
46979406 Duncan, P. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single
Application to Bare Ground - Southern Europe (Sicily). Project Number:
DUPONT/14442, 685483, 24126. Unpublished study prepared by Charles River
Laboratories. 202 p.
46979407 Duncan, P.; Fraser, G. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a
Single Application to Bare Ground - Northern Europe (Poland). Project Number:
DUPONT/14443, 685478, 24119. Unpublished study prepared by Charles River
Laboratories. 191 p.
46979408 Duncan, P. (2006) The Field Soil Dissipation of DPX-E2Y45 Following a Single
Application to Bare Ground - Northern Europe (Germany). Project Number:
DUPONT/14444, 685462, 24125. Unpublished study prepared by Charles River
Laboratories and Agroplan. 207 p.
46979409 McCorquodale, G.; Addison, L.; Coyle, D. (2005) Anaerobic Soil Metabolism of
(Carbon 14)-DPX-E2Y45. Project Number: DUPONT/14568, 804958. Unpublished
study prepared by Inveresk Research International. 74 p.
46979410 Foster, A.; Cairns, S. (2005) Magnitude of DPX-E2Y45, IN-EQW78, IN-ECD73, and
IN-F6L99 Residues in Processed Fractions of Wine Grapes (Berries and Small Fruits)
Following Foliar Applications of DPX-E2Y45 20SC [200 g a.s./L (w/v); 18.5% (w/w)] -
Europe, 2004. Project Number: DUPONT/14572, 685394. Unpublished study
prepared by Inveresk Research International. 197 p.
46979411 Morriss, A.; Coyle, D. (2005) Rate of Degradation of (Carbon 14)-IN-ECD73 in Five
Aerobic Soils. Project Number: DUPONT/14620, 805642. Unpublished study
prepared by Inveresk Research International. 91 p.
46979412 Lowrie, C.; Coyle, D. (2005) The Degradation of (Carbon 14)-ln-EQW78 in Five
Aerobic Soils. Project Number: DUPONT/14621, 805621. Unpublished study
prepared by Inveresk Research International. 82 p.
46979413 Lowrie, C.; McCorquodale, G. (2005) The Degradation of (Carbon 14)-IN-F6L99 in
Five Aerobic Soils. Project Number: DUPONT/14623, 805087. Unpublished study
prepared by Inveresk Research International. 92 p.
46979414 Singles, S.; Berg, D. (2006) Leaching Potential of DPX-E2Y45 Residues in Fresh
Spiked Soil, Aged Soil, and Post-Extraction Soil. Project Number: DUPONT/14624.
Unpublished study prepared by E.I. du Pont de Nemours and Co., Inc. 58 p.
46979415 Lowrie, C. (2005) IN-EQW78 (a Metabolite of DPX-E2Y45): Batch Equilibrium
(Adsorption/Desorption) in Five Soils. Project Number: DUPONT/14625, 805600.
46
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Unpublished study prepared by Inveresk Research International. 62 p.
46979416 Mattson, L. (2006) Adsorption/Desorption of (Carbon 14)DPX-E2Y45 in Twenty-Two
Soils. Project Number: DUPONT/14626, REVISION/NO/1. Unpublished study
prepared by E.I. du Pont de Nemours and Co., Inc. 61 p.
46979417 Morriss, A.; Coyle, D. (2005) IN-ECD73 (A Metabolite of DPX-E2Y45): Batch
Equilibrium (Adsorption/Desorption) in Five Soils. Project Number: DUPONT/14627,
805616. Unpublished study prepared by Inveresk Research International. 62 p.
46979418 Singles, S.; Berg, D. (2005) Aged Desorption of (Carbon 14)-DPX-E2Y45 in Three
Soils. Project Number: DUPONT/14628. Unpublished study prepared by E.I. du Pont
de Nemours and Co., Inc. 77 p.
46979419 Moore, L. (2004) DPX-E2Y45: Photochemical Oxidative Degradation. Project
Number: DUPONT/14637. Unpublished study prepared by E.I. du Pont de Nemours
and Co., Inc. 11 p.
46979420 Lehmhus, J. (2005) DPX-E2Y45 20SC [200 g a.s./L (w/v); 18.5% (w/w)]: A Field
Study to Evaluate Effects on Predatory Mites in Apple Orchards in Italy, 2004: Final
Report. Project Number: 20041116/11/NFTP, DUPONT/14704, 15202. Unpublished
study prepared by GAB Biotechnologie Gmbh. 42 p.
46979421 Lehmhus, J. (2005) DPX-EWY45 35WG: A Field Study to Evaluate Effects on
Predatory Mites in Grape Vineyards in Southern France, 2004: Final Report. Project
Number: 20041093/F1/NFTP, DUPONT/14705, 15181. Unpublished study prepared
by GAB Biotechnologie Gmbh. 41 p.
46979422 Schur, A. (2005) DPX-E2Y45 20SC [200 g a.s./L (w/v), 18.5% (w/w)]: A Semi-Field
Study to Evaluate Effects on the Honey Bee (Apis mellifera carnica; Hymenoptera,
Apidae) in Phacelia in Germany 2004: Final Report. Project Number:
20041116/01/BZEU, DUPONT/14706, 15245. Unpublished study prepared by GAB
Biotechnologie Gmbh. 46 p.
46979423 Rodgers, C.; Stry, J. (2005) Multiresidue Method Testing for DPX-E2Y45 According to
PAM I, Appendix II, as Updated January, 1994. Project Number: DUPONT/14717,
48939. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 60 p.
46979424 Macpherson, D.; Davidson, J.; Lowrie, C. (2006) The Distribution and Metabolism of
(Carbon 14)-DPX-D2Y45 in the Laying Hen. Project Number: DUPONT/14776,
207041. Unpublished study prepared by Charles River Laboratories. 117 p.
46979425 Grant, J.; Carringer, S. (2005) Crop Rotation Study with DPX-E2Y45 35WG
Insecticide - EPA Cropping Region 12 - 2004, USA. Project Number:
DUPONT/14818, 48860. Unpublished study prepared by Carringers, Inc. and
Analytical Bio-Chemistry Labs., Inc. 86 p.
46979426 Morriss, A.; Coyle, D. (2005) IN-F6L99 (A Metabolite of DPX-E2Y45): Batch
Equilibrium (Adsorption/Desorption) in Five Soils. Project Number: DUPONT/14835,
805380. Unpublished study prepared by Inveresk Research International. 64 p.
46979427 Bouchelle, L. (2006) LBA24-002: Static, Acute, 24-Hour Lead Optimization Screen
Using Daphnia magna. Project Number: DUPONT/14889, 15272, 246. Unpublished
study prepared by Dupont Haskell Laboratory. 9 p.
46979428 Bouchelle, L. (2006) LBA22-002: Static, Acute, 24-Hour Lead Optimization Screen
Using Daphnia magna. Project Number: DUPONT/14890, 15260, 246. Unpublished
study prepared by Dupont Haskell Laboratory. 9 p.
46979429 Bilas, J.; Stry, J. (2004) Analytical Method for the Determination of DPX-E2Y45 and
IN-EQW78 in Water Using GC-ECD. Project Number: DUPONT/14940. Unpublished
study prepared by E.I. du Pont de Nemours and Co., Inc. 58 p.
47
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46979430 Bilas, J.; Gagnon, M.; Stry, J. (2005) Analytical Method for the Determination of DPX-
E2Y45 in Soil Using GC-ECD. Project Number: DUPONT/14942. Unpublished study
prepared by E.I. du Pont de Nemours and Co., Inc. 63 p.
46979431 Neeley, M. (2005) Independent Laboratory Validation of the Analytical Method,
DuPont-14819, "Analytical Method for the Determination of DPX-E2Y45, IN-E1W78,
IN-ECD73, IN-F6L99, and IN-GAZ70 in Soil". Project Number: P0001221,
DUPONT/15024. Unpublished study prepared by Exygen Research. 36 p.
46979432 Rzepka, S. (2006) Validation of Multi-Residue Method DFG S 19 (L 00.00-34) for the
Determination of Residues of DPX-E2Y45 and its Metabolites IN-EQW78, IN-GAZ70,
IN-HXH44, and IN-K9TOO in Different Animal Matrices with LC-MS/MS Detection.
Project Number: DUPONT/15025, DUP/0505V, G05/0134. Unpublished study
prepared by Eurofins Analytik GmbH. 122 p.
46979433 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to the
Mayfly, Centroptilum triangulifer. Project Number: DUPONT/15109, 15142, 1487.
Unpublished study prepared by Dupont Haskell Laboratory. 37 p.
46979434 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to
Chironomus riparius. Project Number: DUPONT/15112, 15142, 1381. Unpublished
study prepared by Dupont Haskell Laboratory. 36 p.
46979435 Samel, A. (2005) DPX-E2Y45 35WG: Static, Acute, 48-Hour Toxicity Test to Daphnia
magna. Project Number: DUPONT/15113, 15181, 241. Unpublished study prepared
by Dupont Haskell Laboratory. 38 p.
46979436 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to
Hyalella azteca. Project Number: DUPONT/15114, 15142, 1380. Unpublished study
prepared by Dupont Haskell Laboratory. 33 p.
46979437 Samel, A. (2005) DPX-E2Y45 35WG: Static, Acute, 96-Hour Toxicity Test to Rainbow
Trout, Oncorhynchus mykiss. Project Number: DUPONT/15386, 15181, 228.
Unpublished study prepared by Dupont Haskell Laboratory. 35 p.
46979438 Samel, A. (2005) IN-EQW78: Static, Acute, 48-Hour Limit Test to Daphnia magna.
Project Number: DUPONT/15388, 15440, 241. Unpublished study prepared by
Dupont Haskell Laboratory. 33 p.
46979439 Samel, A. (2005) DPX-E2Y45 35WG: Static, Acute, 96-Hour Limit Test to Bluegill
Sunfish, Lepomis macrochirus. Project Number: DUPONT/15396, 15181, 226.
Unpublished study prepared by Dupont Haskell Laboratory. 35 p.
46979440 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to Adult
Populations of Daphnia magna. Project Number: DUPONT/15868, 15142, 241.
Unpublished study prepared by Dupont Haskell Laboratory. 43 p.
46979441 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to
Crayfish, Oronectes virilis. Project Number: DUPONT/15872, 15142, 314.
Unpublished study prepared by Dupont Haskell Laboratory. 31 p.
46979442 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to the
Aquatic Oligochaete, Lumbriculus variegatus. Project Number: DUPONT/15873,
15142, 1492. Unpublished study prepared by Dupont Haskell Laboratory. 31 p.
46979443 Samel, A. (2005) DPX-E2Y45 Technical: 21-Day Chronic, Static-Renewal Toxicity
Test to Daphnia magna. Project Number: DUPONT/15874, 15142, 254. Unpublished
study prepared by Dupont Haskell Laboratory. 69 p.
46979444 Samel, A. (2005) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to
Gammarus pseudolimnaeus. Project Number: DUPONT/15877, 15142, 1384.
Unpublished study prepared by Dupont Haskell Laboratory. 36 p.
48
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46979445 Bilas, J.; STry, J. (2005) Analytical Method for the Determination of DPX-E2Y45 and
Degradation Products in Water Using LC/MS/MS. Project Number: DUPONT/16058.
Unpublished study prepared by E.I. du Pont de Nemours and Co., Inc. 87 p.
46979446 Giffard, H. (2006) DPX-E2Y45 20SC [200 g a.s./L (w/v), 18.5% (w/w)]: A Semi-Field
Study to Evaluate Effects on the Honey Bee (Apis mellifera mellifera; Hymenoptera,
Apidae) on Phacelia in France 2005. Project Number: 85/2005, DUPONT/16271,
WR/15748. Unpublished study prepared by Testapi. 43 p.
46979447 Beuschel, S. (2006) DPX-E2Y45 20SC [200 g a.s./L (w/v), 18.5% (w/w)]: A Semi-
Field Study to Evaluate Effects on the Honey Bee (Apis mellifera carnica;
Hymenoptera, Apidae) in Phacelia tanacetifolia in Northern France 2005: Final
Report. Project Number: 20041116/F2/BZEU, DUPONT/16272, WR/15747.
Unpublished study prepared by GAB Biotechnologie Gmbh. 68 p.
46979448 Clipston, A.; Craig, W. (2006) IN-ECD73: Laboratory Determination of Water
Solubility. Project Number: DUPONT/16512, 209122. Unpublished study prepared by
Charles River Laboratories . 41 p.
46979449 Clipston, A.; Craig, W. (2006) IN-EQW78: Laboratory Determination of Water
Solubility. Project Number: DUPONT/16513, 209138. Unpublished study prepared by
Charles River Laboratories. 44 p.
46979450 Clipston, A.; Craig, W. (2006) Laboratory Determination of the Partition Coefficients
(n-Octanol Water) of DPX-E2Y45 Metabolites (Estimation by HPLC). Project Number:
DUPONT/16514, 209117. Unpublished study prepared by Charles River
Laboratories. 52 p.
46979500 E.I. du Pont de Nemours and Co. Inc. (2007) Submission of Environmental Fate,
Toxicity and Residue Data in Support of the Applications for Registration of DuPont
Altacor WG, DuPont Coragen SC, DuPont E2Y45 SC and DuPont Rynaxypyr
Technical Insecticide and the Petition for Tolerance of DPX-E2Y45 for Use on
Grapes, Potatoes, Wine Grapes, Apricots, Plums, Cherries, Broccoli, Cauliflower,
Cabbage, Mustard Greens, Lettuce, Cottonseed, Cotton Gin Byproducts, Apples,
Pears, Peppers, Tomatoes, Rasin Grapes and Grape Juice. Transmittal of 46
Studies.
46979501 Singles, S.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Prince Edward Island, 2005, Canada [Interim Report].
Project Number: 16518, 49638. Unpublished study prepared by E. I. du Pontde
Nemours Company Inc. and Analytical Bio-Chemistry Labs Inc. 60 p.
46979502 Singles, S.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide in the Presence of a Cover Crop (Peppers) in New Jersey, 2005, USA.
Project Number: 16519, 49646. Unpublished study prepared by Analytical Bio-
Chemistry Labs Inc. 234 p.
46979503 Singles, S.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide in the Presence of a Cover Crop (Grass) in New Jersey, 2005, USA.
Project Number: 16520, 49665. Unpublished study prepared by E. I. du Pont de
Nemours and Co. Inc. and Analytical Bio-Chemistry Labs. Inc. 218 p.
46979504 Huang, F.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Turf in New Jersey, 2005, USA. Project Number: 16521, 49642.
Unpublished study prepared by E. I. du Pont de Nemours and Co. Inc. and Analytical
Bio-Chemistry Labs Inc. 236 p.
46979505 Luhrs, U. (2005) Final Report: IN-EQW78: Effects on the Collembola, Folsomia
Candida in Artificial Soil: Final Report. Project Number: 21632016, 16531, 15761.
Unpublished study prepared by Institut fuer Biologische Analytik und Consulting
IBACON. 27 p.
49
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46979506 Foster, A.; Cairns, S. (2006) Magnitude of DPX-E2Y45 Residues in Potatoes (Potato
Group) Following Foliar Applications of DPX-E2Y45 20SC [200 G A.S./L (W/W)]; 18.5
Percent (W/W)] - Northern and Southern Europe, 2005. Project Number: 16565,
687517. Unpublished study prepared by Charles River Laboratories and Agrolab -
Sindos Analytical Laboratories. 79 p.
46979507 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Table Grapes (Berries and Small Fruit) Following Foliar Applications of DPX-E2Y45
20SC [200 G A.S./L (W/V); 18.5 Percent (W/W)] - Southern Europe, 2005. Project
Number: 16566, 687522. Unpublished study prepared by Charles River Laboratories
and Agrolab - Sindos Analytical Laboratories. 98 p.
46979508 Foster, A.; Cairns, S.; Hunter, T. (2006) Decline of DPX-E2Y45 Residues in Wine
Grapes (Berries and Small Fruit) Following Foliar Applications of DPX-E2Y45 20SC
[200 G A.S./L (W/V); 18.5 Percent (W/W)] - Northern and Southern Europe, 2005.
Project Number: 16567, 687538. Unpublished study prepared by Charles River
Laboratories and Agrolab - Sindos Analytical Laboratories. 101 p.
46979509 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Peaches and Apricots (Stone Fruit) Following Foliar Applications of DPX-E2Y45
20SC [200 G A.S./L (W/W)] - Southern Europe, 2005. Project Number: 16568,
687559. Unpublished study prepared by Charles River Laboratories and Agrolab -
Sindos Analytical Laboratories. 95 p.
46979510 Carringer, S.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Stone Fruit (Plum, Sweet Cherry, Sour Cherry) Following Foliar Applications of DPX-
E2Y45 35WG - Canada and U.S., 2005. Project Number: 16569, 49550. Unpublished
study prepared by Carringers Inc. 217 p.
46979511 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Brassica Vegetables (Broccoli / Cauliflower, Cabbage, Mustard Greens) Following
Foliar Applications of DPX-E2Y45 20SC [200 G AI/L (W/V); 18.5 Percent (W/W)] -
Canada and U.S., 2005. Project Number: 16570, 49568. Unpublished study prepared
by Analytical Bio-Chemistry Labs. Inc. 239 p.
46979512 Foster, A.; Cairns, S.; Hunter, T. (2006) Magnitude and Decline of DPX-E2Y45
Residues in Field Lettuce (Leaf Vegetables) Following Foliar Applications of DPX-
E2Y45 35WG - Southern Europe, 2005. Project Number: 16573, 687585.
Unpublished study prepared by Charles River Laboratories and Agrolab - Sindos
Analytical Laboratories. 96 p.
46979513 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Undelinted Cottonseed and Cotton Gin By-Products Following Foliar Applications of
DPX-E2Y45WG - U.S.A., 2005. Project Number: 16574, 49573. Unpublished study
prepared by Analytical Bio-Chemistry Labs. Inc. 153 p.
46979514 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Fruiting Vegetables (Tomato, Bell Pepper, Non-Bell Pepper) Following Foliar
Applications of DPX-E2Y45 20SC [200 G AI/L (W/V); 18.5% (W/W)] - Canada and
U.S., 2005. Project Number: 16575, 49569. Unpublished study prepared by Analytical
Bio-Chemistry Labs. Inc. 303 p.
46979515 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Apples and Pears (Pome Fruit) Following Foliar Applications of DPX-E2Y45 20SC
[200 G A.S./L (W/V); 18.5% (W/W)] - Northern and Southern Europe, 2005. Project
Number: 687543, 16577. Unpublished study prepared by Charles River Laboratories.
133 p.
46979516 Rice, F.; Rodgers, C. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Potato Tubbers Combined with Magnitude of DPX-E2Y45 Residues in Processed
50
-------
Fractions of Potato Tubers Following Foliar Applications of DPX-E2Y45 35 WG -
Canada and U.S., 2005. Project Number: 16578, 49570. Unpublished study prepared
by Analytical Bio-Chemistry Labs Inc. 223 p.
46979517 Foster, A.; Cairns, S.; Hunter, T. (2006) Magnitude and Decline of DPX-E2Y45
Residues in Field Peppers (Fruiting Vegetables, Solanacea) Following Foliar
Applications of DPX-E2Y45 35 WG - Europe, 2005. Project Number: 687590, 16579.
Unpublished study prepared by Charles River Laboratories and Agrolab - Sindos
Analytical Laboratories. 91 p.
46979518 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications of
DPX-E2Y45 35WG - Europe, 2005. Project Number: 16580, 687627. Unpublished
study prepared by Charles River Laboratories and Agrolab - Sindos Analytical
Laboratories. 96 p.
46979519 Foster, A.; Cairns, S. (2006) Magnitude of DPX-E2Y45 Residues in Field Tomatoes
(Fruiting Vegetables, Solanacea) Following Foliar Applications of DPX-E2Y45 35WG
- Southern Europe, 2005. Project Number: 16581, 687632. Unpublished study
prepared by Charles River Laboratories and Agrolab - Sindos Analytical Laboratories.
96 p.
46979520 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Tomatoes (Fruiting Vegetables, Solanacea) Following Foliar Applications of
DPX-E2Y45 35WG - Europe, 2005. Project Number: 16582, 687653. Unpublished
study prepared by Charles River Laboratories and Agrolab - Sindos Analytical
Laboratories. 90 p.
46979521 Foster, A.; Cairns, S.; Hunter, T. (2006) Magnitude and Decline of DPX-E2Y45
Residues in Protected Cherry Tomatoes (Fruiting Vegetables, Solanacea) Following
Foliar Applications of DPX-E2Y45 35WG - Europe, 2005. Project Number: 16584,
687648. Unpublished study prepared by Charles River Laboratories and Agrolab -
Sindos Analytical Laboratories. 71 p.
46979522 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in Field
Hot Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications of DPX-
E2Y45 35WG - Southern Europe, 2005. Project Number: 16585, 687611.
Unpublished study prepared by Charles River Laboratories and Agrolab - Sindos
Analytical Laboratories. 76 p.
46979523 Foster, A.; Cairns, S.; Hunter, T. (2006) Magnitude and Decline of DPX-E2Y45
Residues in Protected Hot Peppers Capsicum Fructescens (Fruiting Vegetables,
Solancea) Following Foliar Applications of DPX-E2Y45 35WG - Europe, 2005. Project
Number: 16586, 687606. Unpublished study prepared by Charles River Laboratories
and Agrolab - Sindos Analytical Laboratories. 74 p.
46979524 Foster, A.; Cairns, S.; Hunter, T. (2006) Magnitude of DPX-E2Y45, IN-EQ78, IN-
ECD73, and IN-F6L99 Residues in Processed Fractions of Grapes (Berries and Small
Fruit) Following Foliar Applications of DPX-E2Y45 20SC [200 G A.S./L (W/V); 18.5
Percent (W/W)] - Europe, 2005. Project Number: 16590, 687669. Unpublished study
prepared by Charles River Laboratories. 228 p.
46979525 Shepard, E. (2006) Dissipation of Dislodgeable Foliar Residues (DFR) of DPX-E2Y45
Following Two Foliar Applications of DPX-E2Y45 35WG to Apple Trees. Project
Number: 16593, 49846. Unpublished study prepared by Analytical Bio-Chemistry
Labs Inc. 115 p.
46979526 Shepard, E. (2006) Dissipation of Dislodgeable Foliar Residues (DFR) of DPX-E2Y45
Following Two Foliar Applications of DPX-E2Y45 20SC [200 G AI/L (W/V); 18.5%
(W/W)] to Tomato Plants. Project Number: 16894, 49847. Unpublished study
51
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prepared by Analytical Bio-Chemistry Labs Inc. 115 p.
46979527 Singles, S.; Berg, D. (2006) Determination of the Wash-Off Coefficient of DPX-E2Y45
on Representative Crops. Project Number: 16595. Unpublished study prepared by E.
I. du Pont de Nemours and Co. Inc. 25 p.
46979529 Luhrs, U. (2005) Final Report: DPX-E2Y45 35WG: Effects on Reproduction and
Growth of the Earthworm, Eisenia fetida, in Artificial Soil: Final Report. Project
Number: 24161022, 16684, 15749. Unpublished study prepared by Institutfuer
Biologische Analytik und Consulting IBACON. 37 p.
46979530 Busher, B. (2006) Inter Laboratory Validation of DuPont - 16058 "Analytical Method
for the Determination of DPX-E2Y45 and Degradation Products in Water Using
LC/MS/MS". Project Number: 010/31490, 6449, 16708. Unpublished study prepared
by TNO. 74 p.
46979531 Bouchelle, L. (2005) LBA23-000: Static, Acute 24 - Hour Lead Optimization Screen
Using Daphnia magna. Project Number: 16754, 15756, 246. Unpublished study
prepared by E. I. du Pont de Nemours and Co. Inc. 9 p.
46979532 Rice, F.; Rodgers (2006) Crop Rotation Study with DPX-E2Y45 20SC Insecticide -
NAFTA Growing Zone 1A, Canada, 2005. Project Number: 17045, 49695.
Unpublished study prepared by Analytical Bio-Chemistry Labs Inc. 82 p.
46979535 Singles, S.; Berg, D.; Pils, J. (2006) DPX-E2Y45: Adsorption to Soil, Vendure, and
Thatch. Project Number: 17049. Unpublished study prepared by E. I. du Pont de
Nemours and Co. Inc. 55 p.
46979536 Fasano, W. (2006) DPX-E2Y45 35WG: In Vitro Absorption in Rat and Human Skin.
Project Number: 16052, 17075, 1377. Unpublished study prepared by E. I. du Pontde
Nemours and Co. Inc. 81 p.
46979537 Fasano, W. (2006) DPX-E2Y45 35WG: In Vivo Dermal Kinetics in the Rat. Project
Number: 17077, 16052, 1378. Unpublished study prepared by E. I. du Pontde
Nemours and Co. Inc. 55 p.
46979542 Luhrs, U. (2005) IN-ECD73: Acute Toxicity to the Earthworm, Eisenia fetida in
Artificial Soil: Final Report. Project Number: 25861021, 17091, 16011. Unpublished
study prepared by Institut fuer Biologische Analytik und Consulting IBACON. 29 p.
46979545 Rzepka, S. (2006) Independent Laboratory Validation of an Analytical Method for the
Determination of Residues of DPX-E2Y45 and Its Metabolites in Bovine Tissues, Milk
and Eggs Using LC-MS/MS Detection. Project Number: 17123, 0506V, G05/0137.
Unpublished study prepared by Eurofins Analytick GmbH. 112 p.
46979546 Gagon, M.; Stry, J. (2005) Analytical Method for the Determination of DPX-E2Y45 in
Fish Using GC-ECD. Project Number: 17126. Unpublished study prepared by E. I. du
Pont de Nemours and Co. Inc. 49 p.
46979547 Hargreaves, T.; Murphy, C. (2006) DPX-E2Y45: Assessment of Ready
Biodegradability by the Modified Sturm Test. Project Number: 806452, 17176.
Unpublished study prepared by Charles River Laboratories. 29 p.
46979548 Giffard, H. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5% (W/W)]: A Semi-
Field Study to Evaluate Effects on the Honey Bee (Apis mellifera mellifera;
Hymenoptera, Apidae) on Wheat Treated with Artificial Honeydew in France 2005.
Project Number: 78/2005, 17247, 15906. Unpublished study prepared by Testapi. 46
P-
46979550 Warmers, C. (2006) Final Report: DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5
Percent (W/W)]: Non - GLP Laboratory Study to Evaluate the Effects on the Green
Lacewing Chrysoperla carnea Steph. (Neutoptera, Chrysopidae). Project Number:
52
-------
20041116/01/NLCC, 17301, 15747. Unpublished study prepared by GAB
Biotechnologie Gmbh. 36 p.
46979600 Dupont Crop Protection. (2007) Submission of Residue, Toxicity, Fate, Product
Chemistry and Safety Data in Support of the Applications for Registration of DuPont
DPX-E2Y45 SC Insecticide, DuPont Rynaxypyr Technical Insecticide, DuPont
Coragen SC Insecticide, and DuPont Altacor WG Insecticide and the Petition for
Tolerance of DPX-E2Y45 for Use on Apples, Lettuce, Peaches, Pears, Tomatoes,
Turf, Plum, Cherries, Broccoli, Cauliflower, Mustard Greens, Cabbage, Cucumber,
Squash, Cantaloupe, Bell Pepper, Celery and Spinach. Transmittal of 50 Studies.
46979601 Gagnon, M.; Stry, J. (2005) Analytical Method for the Determination of DPX-E2Y45 in
Cloth by LC/MS/MS. Project Number: DUPONT/17452. Unpublished study prepared
by DuPont Crop Protection. 34 p.
46979602 Bocksch, S. (2005) DPX-E2Y45 Technical: Acute Oral And Contact Toxicity To The
Honeybee, Apis mellifera L: Final Report. Project Number: 20041090/01/BLEU,
DUPONT/17582, 16067. Unpublished study prepared by GAB Biotechnologie Gmbh.
47 p.
46979603 Samel, A. (2006) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to the
Caddisfly Chimarra atterima. Project Number: DUPONT/17585, 16067, 1531.
Unpublished study prepared by E. I. Du Pont de Nemours and Co, Inc. 36 p.
46979604 Luhrs, U. (2005) ln-F6L99: Acute Toxicity To The Earthworm, Eisenisa Fetida In
Artificial Soil. Project Number: 25881021, DUPONT/17631, 16050. Unpublished study
prepared by Institut fuer Biologische Analytik und Consulting IBACON. 29 p.
46979605 Luhrs, U. (2006) ln-ECD73: Effects on Reproduction And Growth of The Earthworm,
Eisenia Fetida, In Artificial Soil: Final Report. Project Number: 25862022,
DUPONT/17632, 16011. Unpublished study prepared by Institut fuer Biologische
Analytik und Consulting IBACON. 39 p.
46979606 Luhrs, U. (2006) IN-GAZ70: Effects on Reproduction and Growth of the Earthworm,
Eisenia fetida, in Artificial Soil: Final Report. Project Number: 25872022,
DUPONT/17633, 16012. Unpublished study prepared by Institut fuer Biologische
Analytik und Consulting IBACON. 39 p.
46979607 Samel, A. (2006) DPX-E2Y45 Technical: Acute, Variable Exposure Toxicity Test with
Recovery to Daphnia magna. Project Number: DUPONT/17653, 16067, 241.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 41 p.
46979608 Fraser, G. (2006) Validation of an Analytical Method for the Determination of DPX-
E2Y45 in Nectar, Pollen and Wax from Honey Bees. Project Number: 26713,
DUPONT/17921, 209583. Unpublished study prepared by Charles River
Laboratories. 42 p.
46979609 Warmers, C. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5% (w/w)]: An
Extended Laboratory Rate Response Test to Study the Effects on the Ladybird
Beetle, Coccinella septempunctata L. (Coleoptera, Coccinellidae): Final Report.
Project Number: 20051280/01/NECS, DUPONT/18079, 16231. Unpublished study
prepared by GAB Biotechnologie Gmbh. 40 p.
46979610 Sloman, T. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: Static, 72-Hour
Growth Inhibition Limit Test to the Green Alga, Pseudokirchneriella subcapitata.
Project Number: DUPONT/18088, 16231, 280. Unpublished study prepared by E. I.
du Pont de Nemours and Co, Inc. 36 p.
46979611 Sloman, T. (2006) DPX-E2Y45 35WG: Static, 72-Hour Growth Inhibition Limit Test to
the Green Alga, Pseudokirchneriella subcapitata. Project Number: DUPONT/18089,
16169, 280. Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 35
53
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p.
46979612 Samel, A. (2006) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Screening
Test with Copepods. Project Number: DUPONT/18090, 16342, 1533. Unpublished
study prepared by E. I. du Pont de Nemours and Co., Inc. 10 p.
46979613 Hatzenbeler, C. (2006) Calculated Theoretical Lifetime For DPX-E2Y45 in the Top
Layer of Aqueous Systems. Project Number: DUPONT/18336. Unpublished study
prepared by E. I. du Pontde Nemours and Co, Inc. 13 p.
46979614 Bouchelle, L. (2006) ln-GAZ70: Static, Acute, 48-Hour Limit Test to Daphnia magna.
Project Number: DUPONT/18387, 16215, 241. Unpublished study prepared by E. I.
du Pont de Nemours and Co, Inc. 32 p.
46979615 Warmers, C. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5% (W/W)]: A
Laboratory Rate Response Test to Evaluate the Effects on the Predatory Mite
Typhlodromus pyri Scheuten (Acariphytoseiidae): Final Report. Project Number:
20051280/01/NLTP, DUPONT/18424, WR16231. Unpublished study prepared by
GAB Biotechnologie Gmbh. 38 p.
46979616 Bocksch, S. (2006) DPX-E2Y45 20SC [200 G/L (W/V); 18.5% (W/W)]: Acute Oral and
Contact Toxicity to the HoneyBee, Apis Mellifera L. Project Number:
20051280/01/BLEU, DUPONT/18426, 16231. Unpublished study prepared by GAB
Biotechnologie Gmbh. 43 p.
46979617 Samel, A. (2006) DPX-E2Y45 20SC [200g/L (W/V); 18.5% (W/W)]: Static, Acute, 48-
Hour Toxicity Test to Daphnia magna. Project Number: DUPONT/18427, 16231, 241.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 42 p.
46979618 Turner, J. (2006) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Screening
Test with Rotifers, Brachionus calyciflorus. Project Number: DUPONT/18428, 16342,
1529. Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 9 p.
46979623 Daly, R.; White, C.; Brugger, K. (2006) DPX-E2Y45: Summary of Insecticide
Screening Data for Parent Compound and Major Metabolites. Project Number:
DUPONT/18487. Unpublished study prepared by E. I. du Pont de Nemours and Co,
Inc. 18 p.
46979624 Samel, A. (2006) DPX-E2Y45 20SC [200g/L (W/V); 18.5% (W/W)]: Static, Acute, 96-
Hour Limit Test to Rainbow Trout, Oncorhynchus mykiss. Project Number:
DUPONT/18601, 16294, 228. Unpublished study prepared by E. I. du Pontde
Nemours and Co, Inc. 35 p.
46979625 Turner, J. (2006) DPX-E2Y45 20SC [200 g/L (W/V); 18.5% (W/W)]: Static, Acute, 96-
Hour Limit Test to Bluegill Sunfish, Lepomis macrochirus. Project Number:
DUPONT/18602, 16294, 226. Unpublished study prepared by E. I. du Pont de
Nemourts and Co, Inc. 33 p.
46979626 Luhrs, U. (2006) DPX-E2Y45 Technical: Effects on The Collembola, Folsomia
Candida in Artificial Soil: Final Report. Project Number: DUPONT/18730, 28451016,
16330. Unpublished study prepared by Institut fuer Biologische Analytik und
Consulting IBACON. 30 p.
46979627 Singles, S. (2006) Calculation of DT50 Values for the Aqueous Photo Products of
DPX-E2Y45 . Project Number: DUPONT/18732. Unpublished study prepared by E. I.
DU PONT DE NEMOURS And Co, Inc. 20 p.
46979628 Samel, A. (2006) DPX-E2Y45 Technical: Static, Acute, 48-Hour Toxicity Test to the
Stonefly, Soyedina carolinensis. Project Number: DUPONT/18804, 16343, 1532.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 35 p.
46979629 Reis, K. (2006) DPX-E2Y45 20SC [200 G/L (W/V); 18.5% (W/W)]: Assessment of The
54
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Effects on Soil Microflora. Project Number: DUPONT/18813, 16353, 1503.
Unpublished study prepared by Institut fuer Biologische Analytik und Consulting
IBACON. 45 p.
46979630 Luhrs, U. (2006) DPX-E2Y45 35WG: Acute Toxicity to The EarthWorm, Eisenia fetida
In Artificial Soil: Final Report. Project Number: DUPONT/18817, 28721021, 16360.
Unpublished study prepared by GAB Biotechnologie Gmbh. 29 p.
46979631 Gagnon, M.; Stry, J. (2006) Stability Of DPX-E2Y45, ln-F9N04, ln-EQW78, ln-GAZ70,
ln-ECD73, and ln-F6L99 Standards In Acetonitrile. Project Number: DUPONT/18842.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 39 p.
46979632 Singles, S.; Hatzenbeler, C. (2006) Calculation of Quantum Yield of the Aqueous
Photo Products Of DPX-E2Y45. Project Number: DUPONT/18858. Unpublished study
prepared by E. I. du Pontde Nemours and Co, Inc. 13 p.
46979633 Gallagher, S.; Beavers, J. (2006) IN-EQW78: An Acute Oral Toxicity Study with the
Northern Bobwhite. Project Number: DUPONT/18859, 16359, 340. Unpublished study
prepared by Wildlife International, Ltd. 47 p.
46979634 Reis, K. (2006) DPX-E2Y45 35WG: Assessment of the Effects on Soil Microfloral:
Final Report. Project Number: DUPONT/18882, 28722080, 16360. Unpublished study
prepared by GAB Biotechnologie Gmbh. 45 p.
46979635 Finlay, C. (2006) ln-EQW78: Acute Oral Toxicity Study in Rats - Up-and-Down
Procedure. Project Number: DUPONT/18942, 16396, 834. Unpublished study
prepared by E. I. du Pont de Nemours and Co, Inc. 27 p.
46979636 Gravell, R. (2006) DPX-E2Y45 35WG Water-Dispersible Granular Insecticide
Formulation: Laboratory Study of Explosive and Oxidizing Properties, Flammability of
Solids, and the Relative Self-Ignition (AutoFlammability) Temperature. Project
Number: DUPONT/19249. Unpublished study prepared by E. I. du Pont de Nemours
and Co, Inc. 14 p.
46979637 Bloemer, D. (2006) DPX-E2Y45 200 G/Liter Suspension Concentrate (SC) Insecticide
Formulation (18.4% A.I.): Laboratory Study of Physical and Chemical Properties.
Project Number: DUPONT/19250. Unpublished study prepared by E. I. du Pont de
Nemours and Co., Inc. 13 p.
46979638 Ford, L. (2006) ln-EQW78: Baceterial Reverse Mutation Test. Project Number:
DUPONT/19414, 16539, 500. Unpublished study prepared by E. I. du Pontde
Nemours and Co, Inc. 52 p.
46979639 Stry, J. (2006) Analytical Method for the Determination of DPX-E2Y45 in Bovine
Tissues, Milk, and Eggs Using GC-ECD. Project Number: DUPONT/19533.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 65 p.
46979640 Jackson, W. (2006) DPX-E2Y45: 200 G/L Suspension Concentrate (SC) Insecticide
Formulation (18.5% W/W): Laboratory Study of Oxidising Properties and Auto-Ignition
Temperature of Liquids. Project Number: DUPONT/19579, HT06/189, 210468.
Unpublished study prepared by Syngenta Technology & Projects. 13 p.
46979641 Strek, H. (2006) Conversion From Units of Parts Per Billion to Grams Parent
Equivalents Per Hectare and Percent of Applied Parent Equivalents in Field Studies.
Project Number: DUPONT/19659. Unpublished study prepared by E. I. du Pont de
Nemours and Co., Inc. 24 p.
46979642 Singles, S. (2006) Details of Soil Collection for Adsorption Studies Conducted with
DPX-E2Y45 and its Soil Metabolites. Project Number: DUPONT/19722. Unpublished
study prepared by E. I. du Pont de Nemours and Co, Inc. 13 p.
46979643 Luhrs, U. (2006) DPX-E2Y45 Technical: Effects on Reproduction of the Predatory
55
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Mite Hypoaspis Aculeifer in Artificial Soil with 5% Peat: Final Report. Project Number:
DUPONT/19748, 28453089, 16558. Unpublished study prepared by Institutfuer
Biologische Analytik und Consulting IBACON. 31 p.
46979644 Singles, S. (2006) Interpretation of the Environmental Behavior of Chlorantraniliprole
(DPX-E2Y45). Project Number: DUPONT/19951. Unpublished study prepared by E. I.
du Pont de Nemours and Co, Inc. 65 p.
46979645 Strek, H. (2006) Interim Field Soil Accumulation Study Results for DPX-E2Y45 in
Europe. Project Number: DUPONT/20511 EU. Unpublished study prepared by E. I.
du Pont de Nemours and Co, Inc. 101 p.
46979646 Huber, A. (2006) Kinetic Sorption of DPX-E2Y45 in Laboratory and Field Soils - A
Modelling Study with Pearlneq Pest and Focus Pearl 2.2.2. Project Number:
DUPONT/20930. Unpublished study prepared by DuPont de Nemours (Deutschland)
GmbH. 85 p.
46979647 Roche, R. (2006) DPX-E2Y45 200 G/L SC: Laboratory Study of Spray Tank Cleanout
of Tank Mixes. Project Number: DUPONT/21122. Unpublished study prepared by E.
I. du Pont de Nemours and Co, Inc. 10 p.
46979648 Pugh, L. (2006) Chlorantraniliprole 35WG (DPX-E2Y45 35WG): Laboratory Study of
Spray Tank Cleanout of Tank Mixes. Project Number: DUPONT/21123. Unpublished
study prepared by E. I. du Pont de Nemours and Co, Inc. 11 p.
46979649 Luhrs, U. (2004) IN-EQW78: Acute Toxicity to the Earthworm, Eisenia Fetida in
Artificial Soil. Project Number: DUPONT/15389, 21631021, 15440. Unpublished study
prepared by GAB Biotechnologie Gmbh. 26 p.
46979650 Stry, J. (2006) Analytical Method for the Determination of DPX-E2Y45 in Bovine
Tissues, Milk, and Eggs Using LC/MS/MS. Project Number: DUPONT/20978.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 51 p.
46979700 E.I. du Pont de Nemours and Co. Inc. (2007) Submission of Product Chemistry,
Toxicity, Environmental Fate, Efficacy, Residue, and Fate Data in Support of the
Applications for Registration of DuPont Rynaxypyr Technical Insecticide, DuPont
Coragen SC Insecticide, DuPont AltacorWG Insecticide, DuPont E2Y45 SC
Insecticide, and the Petition for Tolerance of DPX-E2Y45 for Use on Apples, Lettuce,
Peaches, Pears, Tomatoes, Turf, Plum, Cherries, Broccoli, Cauliflower, Mustard
Greens, Cabbage, Cucumber, Squash, Cantaloupe, Bell Pepper, Celery and Spinach.
Transmittal of 50 Studies.
46979701 Wang, W. (2006) Batch Analysis of DPX-E2Y45 Technical. Project Number: 19379,
E2Y45/220/05/ST. Unpublished study prepared by E. I. Du Pont de Nemours and Co.
Inc. 75 p.
46979702 Wang, W. Batch Analysis of DPX-E2Y45 Technical - Batch Chromatograms. Project
Number: 19379. Unpublished study prepared by E. I. du Pont de Nemours and Co
Inc. 41 p.
46979703 Wang, W. (2006) Analysis of DPX-E2Y45 Test Substance Used in Toxicity Testing.
Project Number: 20771. Unpublished study prepared by E. I. du Pont de Nemours
and Co Inc. 34 p.
46979704 Knabe, S. (2006) DPX-E2Y45 35 WG: Effects on the Decomposition of Organic
Matter in the Field. Project Number: 14330, 20041093/SL/NFLB, 206928.
Unpublished study prepared by GAB Biotechnologie Gmbh. 256 p.
46979705 Platz, S. (2006) Validation of the Analytical Method for Determination of DPX-E2Y45
in Technical Grad DPX-E2Y45. Project Number: 14156. Unpublished study prepared
by E. I. du Pont de Nemours and Co Inc. 23 p.
56
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46979706 Wang, W. (2006) Description and Validation of the Analytical Methods for
Determination of Impurities in Technical Grade DPX-E2Y45. Project Number: 19381,
E2Y45/160/03/ST. Unpublished study prepared by E. I. du Pont de Nemours and Co
Inc. 125 p.
46979707 Wang, W. (2006) DPX-E2Y45: Confirmation of Impurity Analyte Identification in the
Active Ingredient by HPLC / Mass Spectrometry. Project Number: 19381.
Unpublished study prepared by E. I. du Pont de Nemours and Co Inc. 37 p.
46979708 Wang, W. (2006) DPX-E2Y45: Confirmation of Impurity Analyte Identification in the
Active Ingredient by HPLC / UV Spectroscopy. Project Number: 19381. Unpublished
study prepared by E. I. du Pont de Nemours and Co Inc. 37 p.
46979709 Burn, R. (2005) Determination of DPX-E2Y45 Residues in Brassica Vegetables
Following Two and Three Applications of DPX-E2Y45 200 SC Close to Harvest.
Project Number: DPX/E2Y45/BRASSICA, DUP04403, 28/11/03/V9. Unpublished
study prepared by Serve-Ag Research Pty Ltd.. 69 p.
46979710 Burn, R. (2005) Determination of DPX-E2Y45 Residues in Pome Fruit Following Two
and Three Applications of DPX-E2Y45 200 SC to Apples Close to Harvest. Project
Number: DUP/E2Y45/APPLES, DUP04404. Unpublished study prepared by Serve-Ag
Research Pty Ltd.. 57 p.
46979711 Serota, D. (2003) IN-E2Y45: 28 Day Oral Capsule Range-Finding Study in Dogs.
Project Number: 10298, 14033, 883. Unpublished study prepared by MPI Research,
Inc. 507 p.
46979712 MacKenzie, S. (2006) DPX-E2Y45 Technical: Subchronic Toxicity 90 - Day Feeding
Study in Rats. Project Number: 12403, 14503, 1026. Unpublished study prepared by
E. I. du Pont de Nemours and Co Inc. 33 p.
46979713 Luckett, E. (2003) DPX-E2Y45 Technical: 28 - Day Oral Payability Study in Dogs.
Project Number: 125-048, 12440, 14513. Unpublished study prepared by MPI
Research Inc. 106 p.
46979714 Grant, J.; Koch, D. (2005) Crop Rotation Study with DPX-E2Y45 20 SC Insecticide -
EPA Cropping Region 10, USA 2003. Project Number: 12776, 48443. Unpublished
study prepared by Analytical Bio-Chemistry Labs Inc. 89 p.
46979715 Hirata, C. (2006) DPX-E2Y45: Volatility, Calculation of Henry's Law Constant. Project
Number: 13174. Unpublished study prepared by E. I. du Pont de Nemours and Co
Inc. 7 p.
46979716 Cairns, S.; Hunter, T. (2006) Method Validation and Frozen Stability of DPX-E2Y45,
IN-ECD73, IN-EQW78 and IN-F6L99 in Representative Processed Crop Fractions.
Project Number: 13255, 208658, 27066. Unpublished study prepared by Charles
River Laboratories. 191 p.
46979717 Cameron, S.; Cairns, S.; Doran, A. (2006) Validation of an Analytical Method for the
Determination of DPX-E2Y45 in Crops. Project Number: 24483, 13295, 206734.
Unpublished study prepared by Charles River Laboratories. 112 p.
46979718 Luckett, E. (2006) Revised Final Report: DPX-E2Y45 Technical: 1 Year Oral Toxicity
Feeding Study in Dogs. Project Number: 125/051, 1033, 15090. Unpublished study
prepared by MPI Research, Inc. 1109 p.
46979719 MacKenzie, S. (2006) DPX-E2Y45 Technical: Combined Chronic
Toxicity/Oncogenicity Study 2 - Year Feeding Study in Rats. Project Number: 1238,
15091, 14123. Unpublished study prepared by E. I. du Pont de Nemours and Co Inc.
and Experimental Pathology Laboratories, and North Carolina State University. 2818
P-
57
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46979720 Finlay, C. (2006) DPX-E2Y45 Technical: Oncognicity Eighteen - Month Feeding
Study in Mice. Project Number: 14124, 15092, 1029. Unpublished study prepared by
E. I. du Pont de Nemours and Co Inc. 2745 p.
46979721 Malley, L. (2006) DPX-EY45 Technical: Subchronic Oral Neurotoxicity Study in Rats.
Project Number: 14131, 15093, 1264. Unpublished study prepared by E. I. du Pontde
Nemours and Co Inc. 294 p.
46979722 Malley, L. (2006) DPX-E2Y45 Technical: Multigeneration Reproduction Study in Rats.
Project Number: 14132, 15093, 904. Unpublished study prepared by E. I. du Pontde
Nemours and Co Inc. and Experimental Pathology Laboratories and North Carolina
State University. 2812 p.
46979723 Wang, W. (2006) Validation of the HPLC/UV Analytical Method for DPX-E2Y45 in
DPX-E2Y45 35WG and DPX-E2Y45 200 G/L SC (18.4%) End-Use Products. Project
Number: DUPONT/14155/SUPPLEMENT/NO/1, E2Y45/220/03/ST. Unpublished
study prepared by E.I. du Pont de Nemours and Company. 34 p.
46979724 Temple, D.; Beavers, J.; Frey, L.; et. al. (2006) DPX-E2Y45 Technical: A
Reproduction Study with the Northern Bobwhite. Project Number: DUPONT/14383,
15210, 338. Unpublished study prepared by Wildlife International, Ltd. 370 p.
46979725 Temple, D.; Martin, K.; Beavers, J.; et. al. (2006) DPX-E2Y45 Technical: A
Reproduction Study with the Mallard. Project Number: DUPONT/14384, 15210, 339.
Unpublished study prepared by Wildlife International, Ltd. 158 p.
46979726 Dengler, D. (2004) DPX-E2Y45 Technical: Activated Sludge Respiration Inhibition
Test: Final Report. Project Number: 20041090/01/AAHT, DUPONT/14385, 15206.
Unpublished study prepared by GAB Biotechnologie Gmbh. 23 p.
46979727 Ward, T.; Boeri, R.; Wyskiel, D. (2006) DPX-E2Y45 Technical: Influence on Growth
and Growth Rate of the Alga, Navicula pelliculosa. Project Number: 2737/DU,
DUPONT/14392, 15142. Unpublished study prepared by T.R. Wilbury Laboratories,
Inc. 35 p.
46979728 Krueger, H.; Thomas, S.; Kendall, T. (2006) (Carbon 14)-DPX-E2Y45: A Prolonged
Sediment Toxicity Test with Chironomus riparius Using Spiked Water. Project
Number: DUPONT/14395, 112A/200. Unpublished study prepared by Wildlife
International, Ltd. 97 p.
46979729 Krueger, H.; Thomas, S.; Kendall, T. (2005) (Carbon 14)-DPX-E2Y45: A Prolonged
Sediment Toxicity Test with Chironomus riparius Using Spiked Sediment. Project
Number: DUPONT/14396, 112A/194. Unpublished study prepared by Wildlife
International, Ltd. 85 p.
46979730 Sharma, A.; Rice, F.; Gant, A. (2006) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Ohio, 2004, USA. Project Number: DUPONT/14553,
REVISION/NO/1, 48926. Unpublished study prepared by Analytical Bio-Chemistry
Labs., Inc and E. I. du Pont de Nemours and Co., Inc. 228 p.
46979731 Huber, A. (2006) Predicted Concentrations of DPX-E2Y45 and Its Metabolites in
Surface Waters in Europe - A Modeling Study Conducted with Focus Surface Water
Scenarios. Project Number: DUPONT/16523. Unpublished study prepared by DuPont
de Nemours (Deutschland) GmbH. 177 p.
46979732 Huber, A. (2006) Leaching Behaviour of DPX-E2Y45 and Its Metabolites - A Modeling
Study with Focus Pelmo 3.3.2 and Focus Pearl 2.2.2. Project Number:
DUPONT/16524. Unpublished study prepared by DuPont de Nemours (Deutschland).
124 p.
46979733 Warmers, C. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5% (W/W)]: Non-GLP
58
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Laboratory Study to Evaluate the Effects on the Hoverfly Episyrphus balteatus DEC.
(Diptera, Syrphidae) in the Laboratory: Final Report. Project Number:
20041116/01/NLEB, DUPONT/16532, 15747. Unpublished study prepared by GAB
Biotechnologie Gmbh. 31 p.
46979734 Rice, F.; Rodgers, C. (2006) Magnitude of DPX-E2Y45 Residues in Processed
Fractions of Cottonseed Following Foliar Applications of DPX-E2Y45 35WG - U.S.,
2005. Project Number: DUPONT/16589, REVISION/NO/1, 49574. Unpublished study
prepared by Analytical Bio-Chemistry Labs., Inc. 131 p.
46979735 Carringer, S.; Rodgers, C. (2006) Magnitude of DPX-E2Y45 Residues in Processed
Fractions of Plum Following Foliar Applications of DPX-E2Y45 35WG - Canada and
U.S., 2005. Project Number: DUPONT/16591, 49575. Unpublished study prepared by
Carringers, Inc. 95 p.
46979736 Shepard, E. (2006) Dissipation of Dislodgeable Foliar Residues (DFR) of DPX-E2Y45
Following Two Foliar Applications of DPX-E2Y45 20SC [200 G AI/L (W/V); 18.5%
(W/W)] to Cabbage Plants. Project Number: DUPONT/16592, REVISION/NO/I,
49845. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 114 p.
46979737 Pils, J.; Singles, S.; Berg, D. (2006) DPX-E2Y45: Adsorption to Kaolinite and
Montmorillonite (Smectite) Clays. Project Number: DUPONT/16596, REVISION/NO/I.
Unpublished study prepared by E.I. du Pont de Nemours and Co., Inc. 56 p.
46979738 Chapleo, S.; Gray, J. (2006) The Metabolism of (Carbon 14)-DPX-E2Y45 in Rice.
Project Number: DUPONT/16967, 806028. Unpublished study prepared by Charles
River Laboratories. 135 p.
46979739 Fraser, G.; Kinney, J. (2006) Storage Stability of DPX-E2Y45, IN-HXH44, IN-K9TOO,
IN-GAZ70 and IN-EQW78 in Cattle Tissues and Milk Stored Frozen: Interim Report.
Project Number: DUPONT/17004, 209269, 26862. Unpublished study prepared by
Charles River Laboratories . 189 p.
46979740 Fasano, W. (2006) DPX-E2Y45 20SC [200g/L (w/v); 18.5% (w/w)]: In Vivo Dermal
Absorption in the Rat. Project Number: DUPONT/17076, 16216, 1378. Unpublished
study prepared by Dupont Haskell Laboratory. 57 p.
46979741 Fasano, W. (2006) DPX-E2Y45 20SC [200 g/L (w/v); 18.5% (w/w)]: In Vitro
Absorption in Rat and Human Skin. Project Number: DUPONT/17078, 16216, 1377.
Unpublished study prepared by Dupont Haskell Laboratory. 80 p.
46979742 Reis, K. (2006) IN-EQW78: Assessment of the Effects on Soil Microflora: Revised
Final Report No. 1. Project Number: 21633080, DUPONT/17086, 15991. Unpublished
study prepared by Institut fuer Biologische Analytik und Consulting IBACON. 46 p.
46979743 Szinicz, G. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V). 18.5 (W/W)]: A Semi-Field
Study to Determine Residues in Nectar and Pollen from Foraging Honey Bees (Apis
Mellifera Carnica; Hymenoptera, Apidae) and Residues in Fresh Honey, Pollen and
Wax from Combs after Exposure to Treated Phacelia in Germany in 2005: Final
Report. Project Number: 20041116/G2/BZEU, DUPONT/17208, WR/15747.
Unpublished study prepared by GAB Biotechnologie Gmbh. 151 p.
46979744 Beuschel, S. (2006) DPX-E2Y45 20SC [200G A.S./L (W/V), 18.5% (W/W)]: A Semi-
Field Study to Evaluate Effects on the Honey Bee (Apis Mellifera Carnica;
Hymenoptera, Apidae) on Wheat Treated with Artificial Honeydew in Northern France
2005: Final Report. Project Number: 20041116/F1/BZEU, DUPONT/17248,
WR/15907. Unpublished study prepared by GAB Biotechnologie Gmbh. 64 p.
46979745 Warmers, C. (2006) DPX-E2Y45 20SC [200 G A.S./L (W/V), 18.5% (W/W)]: Non-GLP
Laboratory Study to Evaluate the Effects on the Ladybird Beetle Coccinella
septempunctata L. (Coleoptera, Coccinellidae) Under Laboratory Conditions: Final
59
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Report. Project Number: 20041116/01/NLCS, DUPONT/17300, 15747. Unpublished
study prepared by GAB Biotechnologie Gmbh. 37 p.
46979746 Koch, S.; Berg, D. (2006) Rate of Degradation and Soil Adsorption (Koc) Values for
DPX-E2Y45 in Three Brazilian Soils. Project Number: DUPONT/17454,
REVISION/NO/2. Unpublished study prepared by E.I. du Pont de Nemours and Co.,
Inc. 42 p.
46979747 Reis, K. (2006) IN-ECD73: Assessment of the Effects on Soil Microflora: Final Report
Revision 1. Project Number: 25863080, DUPONT/17627, 16011. Unpublished study
prepared by Institut fuer Biologische Analytik und Consulting IBACON. 45 p.
46979748 Reis, K. (2006) IN-GAZ70: Assessment of the Effects on Soil Microflora: Final Report.
Project Number: 25873080, DUPONT/17628, 16012. Unpublished study prepared by
Institut fuer Biologische Analytik und Consulting IBACON. 48 p.
46979749 Everds, N. (2006) Development of Methods for the Evaluation of Adrenal Cortical
Function in Rats. Project Number: DUPONT/17987/REVISION/NO/1, 16116, 1583.
Unpublished study prepared by Dupont Haskell Laboratory. 60 p.
46979750 Fraser, G.; Kinney, J.; Hunter, T. (2006) Validation of an Analytical Method for the
Determination of DPX-E2Y45, IN-EQW78, IN-ECD73, IN-F9N04 and IN-GAZ70 in
Fresh Water Sediment and IN-F9N04 in Soil. Project Number: DUPONT/18017,
209672, 26669. Unpublished study prepared by Charles River Laboratories. 81 p.
46979800 E.I. du Pont Nemours and Company Inc. (2007) Submission of Product Chemistry,
Fate, Environmental Fate, Toxicity and Residue Data in Support of the Applications
for Registration of DuPont Rynaxapyr, DuPont Coragen SC, Dupont AltacorWG, and
DuPont E2Y45 SC Insecticide and the Petition for Tolerance of DPX - E2Y45 for Use
on Tomatoes, Apples, Potatoes, Grapes, Stone Fruit, Citrus, Plums, Pear, Peach,
and Lettuce. Transmittal of 38 Studies.
46979801 Warmers, C. (2006) DPX - E2Y45 20SC [200 G.A.S./ L (W/V), 18.5 Percent (W/W)]:
An Extended Laboratory Rate Response Test to Study the Effects on the Predatory
Bug Orius laevigatus Fieber (Heteroptera, Anthocoridae): Final Report. Project
Number: 20051280/01/NEOR, 18081, 16231. Unpublished study prepared by GAB
Biotechnologie Gmbh. 50 p.
46979802 Warmers, C. (2006) DPX - E2Y45 20 SC [200 G A.S./L (w/v), 18.5 Percent (W/W)]:
An Extended Laboratory Rate Response Test to Study the Effects on the Hoverfly
Episyrphus balteatus DEC. (Diptera, Syrphidae) in the Laboratory: Final Report.
Project Number: 20051280/01/NEEB, 18082, 16231. Unpublished study prepared by
GAB Biotechnologie Gmbh. 48 p.
46979803 Warmers, C. (2006) DPX - E2Y45: An Extended Laboratory Rate Response Test to
Study the Effects on the Hoverfly Episyrphus balteatus DEC. (Diptera, Syrphidae) in
the Laboratory: Final Report. Project Number: 20061114/01/NEEB, 16301, 1444.
Unpublished study prepared by GAB Biotechnologie Gmbh. 38 p.
46979804 Giffard, H. (2006) DPX - E2Y45 20SC [200 G A.S./L (W/V), 18.5 Percent (W/W)]: A
Semi - Field Study to Evaluate Effects on the Honey Bee (Apis mellifera mellifera;
Hymenoptera, Apidae) on Phacelia in France 2006. Project Number: WR/16232,
SC/1515, 102/2006. Unpublished study prepared by Testapi. 44 p.
46979805 Giffard, H. (2006) DPX - E2Y45 20SC [200 G A.S./L (W/V), 18.5 Percent (W/W)]: A
Semi - Field Study to Evaluate Effects on the Honey Bee (Apis mellifera mellifera;
Hymenoptera, Apidae) on Wheat Treated with Artificial Honeydew in France 2006.
unpublished study prepared by Testapi. Project Number: 100/2006, 18086, WR
16233. 44 p.
46979806 Szinicz, G. (2006) DPX - E2Y45 20 SC [200 G A.S./L (W/V), 18.5 Percent (W/W)]: A
60
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Semi - Field Study to Evaluate Effects on the Honey Bee (Apis mellifera carnica;
Hymenoptera, Apidae) in Phacelia tanacetifolia in France 2006: Final Report. Project
Number: 20051280/F2/BZEU, 18087, 16231. Unpublished study prepared by GAB
Biotechnologie Gmbh. 49 p.
46979807 Fraser, G.; Davidson, J.; Cairns, S. (2006) Validation of Analytical Method for the
Determination of DPX - E2Y45 and its Metabolites IN - K9TOO, IN - HXH44, IN -
GAZ70 and IN - EQW78 in Bovine Tissues and Milk: Report Amendment 1. Project
Number: 26549, 18100, 209253. Unpublished study prepared by Charles River
Laboratories. 170 p.
46979808 Carver, R.; Frost, N.; Mitchell, G.; et al. (2006) Chlorantraniliprole (DPX - E2Y45):
Annex MA: Section 1: Identity of the Active Substance, Physical and Chemical
Properties; Further Information on the Active Substance; Proposals Including
Justification of the Proposals for the Classification and Labeling of the Active
Substance: Summaries and Assessment (Tier II - Document M - II). Project Number:
18269. Unpublished study prepared by E. I. du Pont de Nemours and Co. Inc. 107 p.
46979809 Carver, R. (2006) Chlorantraniliprole (DPX - E2Y45): Summaries and Assessment.
Project Number: 18270. Unpublished study prepared by E. I. du Pont de Nemours
and Co., Inc. 156 p.
46979810 Bentley, K.; Oldham, J.; Gaddamidi, V.; et al. (2007) Chlorantraniliprole (DPX -
E2Y45): Mammalian Toxicity: Summaries and Assessment. Project Number: 18271.
Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 328 p.
46979811 Daddamidi, V.; Ruhl, J.; Klemens, A.; et al. (2006) Chlorantraniliprole (DPX - E2Y45):
Residue Chemistry: Summaries and Assessment. Project Number: 18272.
Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 737 p.
46979812 Singles, S. (2006) Chlorantraniliprole (DPX - E2Y45): Fate in the Environment:
Summaries and Assessment. Project Number: 18273. Unpublished study prepared by
E. I. du Pont de Nemours and Co., Inc. 681 p.
46979813 Brugger, K.; Dinter, A.; Samel, A.; et al. (2006) Chlorantramiliprole (DPX - E2Y45):
Ecotoxicology: Summaries and Assessment. Project Number: 18274. Unpublished
study prepared by E. I. du Pont de Nemours and Co., Inc. 489 p.
46979814 Warmers, C. (2006) DPX - E2Y45 20SC [200 G A.S./L (W/W)]: A Laboratory Rate
Response Test to Evaluate the Effects on the Parasitoid Aphidius rhopalosiphi
(Hymenoptera, Braconidae): Final Report. Project Number: 20051280/01/NLAP,
18423, WR/16231. Unpublished study prepared by IFU UmweltanalytikGmbh. 43 p.
46979815 Schaik, F. (2006) ILV of DPX - E2Y45 and Its Metabolites IN - EQW78, IN - GAZ70,
IN - HXH44 and IN - K9TOO in Different Animal Matrices with LC - MS/MS Detection
as Described in DuPont-15025. Project Number: 010/31866, 6688, 18610.
Unpublished study prepared by TNO. 166 p.
46979816 Schaik, F. (2006) ILV of DPX - E2Y45 in 4 Different Crops as Described in DuPont -
13261. Project Number: 010/31865, 6687, 18611. Unpublished study prepared by
TNO. 46 p.
46979817 Schaik, F. (2006) Development of an Analytical Enforcement Method in Air (By
Adsorption on XAD - 2 and LC - MS/MS) for DPX - E2Y45. Project Number: V6685,
6685, 010/31863. Unpublished study prepared by TNO. 30 p.
46979818 Gaddamidi, V.; Dietrich, R. (2006) DPX - E2Y45 Mobility in Plants: Translocation
Through Phloem and Xylem. Project Number: 18777. Unpublished study prepared by
E. I. du Pont de Nemours and Co Inc. 18 p.
46979819 Luhrs, U. (2006) DPX - E2Y45 20 SC [200 G/L (W/V); 18.5 Percent (W/W)]: Acute
61
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Toxicity to the Earthworm, Eisenia fetida in Artificial Soil: Final Report. Project
Number: 27872021, 18818, 16353. Unpublished study prepared by Institutfuer
Biologische Analytik und Consulting IBACON. 30 p.
46979820 Huber, A. (2006) Predicted Concentration of DPX - E2Y45 and Its Metabolites IN -
EQW78, IN - ECD73, IN - F6L99, IN - GAZ70, and IN - F9N04 in Soil. Project
Number: 18937. Unpublished study prepared by E. I. du Pont de Nemours and
Company Inc. 64 p.
46979821 Huber, A. (2006) The Degradation of DPX - E2Y45 in Soil and Aquatic Systems -
Summary of Kinetic Calculations. Project Number: 18938/EU. Unpublished study
prepared by E. I. du Pont De Nemours and Co Inc. 225 p.
46979822 Gallagher, S.; Beavers, J. (2006) DPX - E2Y45 20SC: An Acute Oral Toxicity Study
with the Northern Bobwhite. Project Number: 18945,16399, 340. Unpublished study
prepared by Wildlife International Ltd. 42 p.
46979823 Gallagher, S.; Beavers, J. (2006) DPX - E2Y45 35WG: An Acute Oral Toxicity Study
with the Northen Bobwhite. Project Number: 18946, 16398, 340. Unpublished study
prepared by Wildlife International Ltd. 49 p.
46979824 Porch, J.; Martin, K. (2006) DPX - E2Y45 20SC [200 G/L (W/V); 18.5 Percent (W/W)]:
A Greenhouse Study to Investigate the Effects on Vegetative Vigor of Ten Terrestrial
Plants Following Foliar Exposure. Project Number: 112/576, 19074, 16399.
Unpublished study prepared by Wildlife International Ltd. 58 p.
46979825 Martin, K.; Porch, J. (2006) DPX - E2Y45 20SC [200 G/L (W/V); 18.5 Percent (W/W)]:
A Greenhouse Study to Investigate the Effects on Seedling Emergence and Growth
of Ten Terrestrial Plants Following Soil Exposure. Project Number: 112/575, 19075,
16399. Unpublished study prepared by Wildlife International Ltd. 93 p.
46979826 Singles, S.; Berg, D. (2006) (Carbon 14) - DPX - E2Y45: Effects of Aging on
Extractability from Artificial Soil. Project Number: 19239. Unpublished study prepared
by E. I. du Pont de Nemours and Co Inc. 45 p.
46979827 Gravell, R. (2006) DPX - E2Y45 200 G / Liter Suspension Concentration (SC)
Insecticide Formulation (18.4 Percent A.I.): Laboratory Study of Explosive Properties.
Project Number: 19252. Unpublished study prepared by E. I. du Pont de Nemours
and Co Inc. 9 p.
46979828 Bloemer, D. (2006) DPX - E2Y45 35 WG Water - Dispersible Granular Insecticide
Formulation: Laboratory Study of Physical and Chemical Properties. Project Number:
19255. Unpublished study prepared by E. I. du Pont de Nemours and Co Inc. 15 p.
46979829 Myhre, A. (2006) IN - LBA24: Bacterial Reverse Mutation Test. Project Number:
19377, 16515, 502. Unpublished study prepared by E. I. du Pont de Nemours and
Co. Inc. 33 p.
46979830 Finlay, C. (2006) IN - LBA24: Acute Oral Toxicity Study in Mice - Up and Down
Procedure. Project Number: 19403, 16515, 835. Unpublished study prepared by E. I.
du Pont de Nemours and Co. Inc. 26 p.
46979831 Gallagher, S.; Beavers, J. (2006) DPX - E2Y45 20 SC: A Dietary LC 50 Study with
the Northern Bobwhite. Project Number: 16510, 19420, 1619. Unpublished study
prepared by Wildlife International Ltd. 62 p.
46979844 Carver, R.; Cosgrove, T.; Frost, N.; et al. Chlorantraniliprole 20SC (DPX - E2Y45
20SC) 200 G/L Suspension Concentrate Formulation: Annex MIA: Section 1: Identity
of the Plant Protection Product, Physical Chemical and Technical Properties of the
Plant Protection Product; Data on Application; Further Information on the Plant
Protection Product; Labeling of the Plant Protection Product; Proposals for Risk and
62
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Safety Phrases and the Proposed Label: Summaries and Assessment (Tier II -
Document M - III). Project Number: 19489. Unpublished study prepared by E. I. du
Pont de Nemours and Co. Inc. 76 p.
46979845 Stry, J.; McNally, M. (2006) Chlorantraniliprole 20SC (DPX - E2Y45 20SC) 200 G/L
Suspension Concentrate Formulation: Analytical Methods: Summaries and
Assessment. Project Number: 19490. Unpublished study prepared by E. I. du Pont de
Nemours and Co., Inc. 30 p.
46979846 Bentley, K.; Mullin, L; Frost, L; et al. (2006) Chlorantraniliprole 20SC (DPX - E2Y45
20SC) 200 G/L Suspension Concentrate Formulation: Mammalian Toxicology:
Summaries and Assessment. Project Number: 19491. Unpublished study prepared by
E. I. du Pont de Nemours and Co., Inc. 82 p.
46979847 Gaddamiki, V.; Ruhl, J. (2006) Chlorantraniliprole 20SC (DPX - E2Y45 20 SC) 200 G
/ L Suspension Concentrate Formulation: Residue Chemistry: Summaries and
Assessment. Project Number: 19492. Unpublished study prepared by E. I. du Pont de
Nemours and Co., Inc. 38 p.
46979848 Huber, A.; Singles, S. (2006) Chlorantraniliprole 20SC (DPX - E2Y45 20SC) 200 G / L
Suspension Concentrate Formulation: Fate in the Environment: Summaries and
Assessment. Project Number: 19493. Unpublished study prepared by E. I. du Pont de
Nemours and Co., Inc. 142 p.
46979849 Brugger, K.; Dinter, A. (2007) Chlorantraniliprole 20SC (DPX - E2Y45 20SC) 200 G /
L Suspension Concentrate Formulation: Ecotoxicology: Summaries and Assessment.
Project Number: 19494. Unpublished study prepared by E. I. du Pont de Nemours
and Co., Inc. 308 p.
46979850 Frost, N.; McNally, M.; Stry, J.; et al. (2007) Chlorantraniliprole (DPX - E2Y45) Active
Substance and Plant Protection Products DPX - E2Y45 20SC and DPX - E2Y45 WG:
Overall Summary and Assessment. Project Number: 19496. Unpublished study
prepared by E. I. du Pont de Nemours and Co. Inc. 296 p.
46979900 E.I. Du Pont de Nemours and Co., Inc. (2007) Submission of Product Chemistry,
Fate, Toxicity and Residue Data in Support of the Applications for Registration of
DuPont Altacor WG Insecticide, DuPont Coragen SC Insecticide, DuPont E2Y45 SC
Insecticide and DuPont Rynaxpyr Technical and the Petition for Tolerance of DPX-
E2Y45 on Apples, Lettuce, Peaches, Pears, Tomatoes, Turf, Plum, Cherries,
Broccoli, Cauliflower, Mustard Greens, Cabbage, Cucumber, Squash, Cantaloupe,
Bell Pepper, Celery and Spinach. Transmittal of 48 Studies.
46979901 Carver, R.; Cosgrove, T.; Frost, N.; et al. (2006) Chlorantraniliprole 35WG (DPX-
E2Y45 35WG) Water-Dispersible Granular Formulation Annex MIA: Section 1: Identity
of the Plant Protection Product, Physical, Chemical and Technical Properties of the
Plant Protection Product; Data on Application; Further Information on the Plant
Protection Product; Proposals Including Justification of the Proposals for the
Classification and Labeling of the Plant Protection Product; Proposals for Risk and
Safety Phrases and the Proposed Label Summaries and Assessment (Tier II -
Document M-lll . Project Number: 19504. Unpublished study prepared by E. I. Du
Pont de Nemours and Co., Inc. 71 p.
46979902 Stry, J.; McNally, M. (2006) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-
Dispersible Granular Formulation Annex MIA: Section 2; Analytical Methods
Summaries and Assessment (Tier II - Document M-lll). Project Number: 19505.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 26 p.
46979903 Bentley, K.; Mullin, L.; Frost, L.; et al. (2006) Chlorantraniliprole 35WG (DPX-E2Y45
35WG) Water-Dispersible Granular Formulation Annex IMA: Section 3; Mammalian
Toxicology Summaries and Assessment (Tier II - Document M-lll). Project Number:
63
-------
19506. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 67 p.
46979904 Gaddamidi, V.; Ruhl, J. (2006) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-
Dispersible Granular Formulation Annex MIA: Section 4; Residue Chemistry
Summaries and Assessment (Tier II - Document M-lll). Project Number: 19507.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 33 p.
46979905 Huber, A.; Singles, S. (2006) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-
Dispersible Granular Formulation Annex MIA: Section 5: Fate in the Environment
Summaries and Assessment (Tier II - Document M-lll). Project Number: 19508.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 111 p.
46979906 Brugger, K.; Dinter, A. (2007) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-
Dispersible Granular Formulation Annex MIA: Section 6: Ecotoxicology Summaries
and Assessment (Tier II - Document M-lll). Project Number: 19509. Unpublished
study prepared by E. I. Du Pont de Nemours and Co., Inc. 284 p.
46979907 Mullin, L. (2006) Occupational Handler and Post-Application Risk Assessment: DPX-
E2Y45 20SC. Project Number: 19582. Unpublished study prepared by E. I. Du Pont
de Nemours and Co., Inc. 21 p.
46979908 Mullin, L. (2006) Occupational Handler and Post-Application Risk Assessment: DPX-
E2Y45 20SC on Turf and Landscape Ornamentals. Project Number: 19583.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 24 p.
46979909 Thums, R. (2006) Dietary Risk Assessments in Support of Maximum Residue Levels
for Chlorantraniliprole in Europe. Project Number: 19615/EU. Unpublished study
prepared by E. I. Du Pont de Nemours and Co., Inc. 36 p.
46979910 Burn, R. (2006) Determination of DPX-E2Y45 Residues in Pome Fruit Following Two
and Three Applications of DPX-E2Y45 200 SC or DPX-E2Y45 350 WG to Apples and
Pears Close to Harvest Australia, 2005/06. Project Number:
03P01RES221/E2Y45/MOR, 19725. Unpublished study prepared by AgriSolutions
Australia Pty Ltd. and Serve-Ag Research Pty Ltd. 79 p.
46979911 Burn, R. (2006) Determination of DPX-E2Y45 Residues in Brassica Vegetables
Following Two and Three Applications of DPX-E2Y45 200 SC Close to Harvest
Australia, 2005/06. Project Number: 03P01RES222/E2Y45/MOR, 19726.
Unpublished study prepared by Serve-Ag Research Pty Ltd. 78 p.
46979912 Burn, R. (2006) Determination of DPX-E2Y45 Residues in Brassica Vegetables
Following Two and Three Applications of DPX-E2Y45 200 SC Close to Harvest New
Zealand, 2005/06. Project Number: 03P01RES223E2Y45MOR, 19727. Unpublished
study prepared by Serve-Ag Research Pty Ltd. 38 p.
46979913 Warmers, C. (2006) DPX-E2Y45 20SC: An Extended Laboratory Test with Field-Aged
Spray Deposits to Study the Effects on the Ladybird Beetle, Coccinella
septempunctata L. (Coleoptera, Coccinellidae): Final Report. Project Number:
20051280/02/NECS, 19746, 16557. Unpublished study prepared by
Arbeitsgemeinschaft GAB Biotechnologie. 50 p.
46979914 Warmers, C. (2006) DPX-E2Y45 20SC: An Extended Laboratory Test with Field-Aged
Spray Deposits to Study the Effects on the Hoverfly Episyrphus balteatus Deg.
(Diptera, Syrphidae). Project Number: 20051280/02/NEEB, 19747, 16557.
Unpublished study prepared by Arbeitsgemeinschaft GAB Biotechnologie. 49 p.
46979915 Jarvis, N. (2006) Simulation of Drainage Inputs of DPX-E2Y45 to Surface Water in
the EU using MACRO5. Project Number: 19827. Unpublished study prepared by
Swedish University of Agric. Sciences. 8 p.
46979916 Geelen, J. (2006) Determination of DPX-E2Y45 Residues in Apples Following Either
64
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Early or Late Season Applications of DPX-E2Y45 350WG. Project Number: 1160,
19904. Unpublished study prepared by Agro-Research, J.A.R. Geelen Research, Ltd.
101 p.
46979917 Vaughn, A. (2006) Use Description/Scenario for Use of DPX-E2Y45 in Canada on
Fruit and Vegetable Crops and Turf. Project Number: 20084. Unpublished study
prepared by E.I. Du Pont Canada Co. 13 p.
46979918 Finlay, C. (2006) DPX-E2Y45 Technical: Acute Oral Toxicity Study in Rats - Up-and-
Down Procedure. Project Number: 20292, 16722, 834. Unpublished study prepared
by E. I. Du Pont de Nemours and Co., Inc. 26 p.
46979919 Finlay, C. (2006) DPX-E2Y45 Technical: Acute Dermal Irritation Study in Rabbits.
Project Number: 20293, 16722, 1008. Unpublished study prepared by E. I. Du Pont
de Nemours and Co., Inc. 22 p.
46979920 Finlay, C. (2006) DPX-E2Y45 Technical: Acute Eye Irritation Study in Rabbits. Project
Number: 20294, 16722, 602. Unpublished study prepared by E. I. Du Pont de
Nemours and Co., Inc. 21 p.
46979921 Myhre, A. (2006) DPX-E2Y45 Technical: Bacterial Reverse Mutation Test. Project
Number: 20296, 16722, 500. Unpublished study prepared by E. I. Du Pont de
Nemours and Co., Inc. and Critical Path Services LLC. 61 p.
46979922 Glatt, C. (2006) DPX-E2Y45 Technical: In Vitro Mammalian Chromosome Aberration
Test in Human Peripheral Blood Lymphocytes. Project Number: 20297, 16722, 544.
Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 36 p.
46979923 Warmers, C. (2006) DPX-E2Y45 35WG: An Extended Laboratory Test with Field-
Aged Spray Deposits to Study the Effects on the Hoverfly Episyrphus balteatus DEC.
(Diptera, Syrphidae). Project Number: 20061114/02/NEEB, 20303, 16713.
Unpublished study prepared by Arbeitsgemeinschaft GAB Biotechnologie. 49 p.
46979924 Mullin, L. (2006) DPX-E2Y45 35WG: Occupational Handler and Post-Application Risk
Assessment. Project Number: 20361. Unpublished study prepared by E. I. Du Pont
de Nemours and Co, Inc. 23 p.
46979925 Frost, L. (2006) DPX-E2Y45 35WG - Operator, Bystander and Worker Exposure Risk
Assessment for Submission in the EU. Project Number: 20362EU. Unpublished study
prepared by E. I. Du Pontde Nemours and Co., Inc.. 19 p.
46979926 Frost, L. (2006) DPX-E2Y45 20SC - Operator, Bystander and Worker Exposure Risk
Assessment for Submission in the EU. Project Number: 20364EU. Unpublished study
prepared by E. I. Du Pontde Nemours and Co., Inc. 19 p.
46979927 Everds, N. (2006) Evaluation of Histologic Changes in the Adrenal Cortex of Rats
Administered DPX-E2Y45 . Project Number: 20406. Unpublished study prepared by
E. I. Du Pont de Nemours and Co., Inc. 45 p.
46979928 Finlay, C. (2006) IN-ECD73: Acute Oral Toxicity Study in Mice - Up-and-Down
Procedure. Project Number: 20594, 16785, 835. Unpublished study prepared by E. I.
Du Pont de Nemours and Co., Inc. 27 p.
46979929 Finlay, C. (2006) IN-F69L99: Acute Oral Toxicity Study in Mice - Up-and-Down
Procedure. Project Number: 20595, 16784, 835. Unpublished study prepared by E. I.
Du Pont de Nemours and Co., Inc. 27 p.
46979930 Myhre, A. (2006) IN-ECD73: Bacterial Reverse Mutation Test. Project Number:
20596, 16785, 500. Unpublished study prepared by E. I. Du Pont de Nemours and
Co., Inc. 54 p.
46979931 Myhre, A. (2006) IN-F6L99: Bacterial Reverse Mutation Test. Project Number: 20597,
65
-------
16784, 500. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc.
52 p.
46979932 Morre, J. (2006) Magnitude of Chlorantramiliprole (DPX-E2Y45) Residues on Apples
(Malus domestica): Studies Carried Out in the Republic of Argentina 2005-2006
Campaign. Project Number: 20737, 001/2006. Unpublished study prepared by E. I.
Du Pont de Nemours and Co. Inc. and Microquim S.A. 50 p.
46979933 Moore, J. (2006) Magnitude of Chlorantraniliprole (DPX-E2Y45) Residues on
Peaches (Prunus persicae): Studies Carried Out in the Republic of Argrentina 2005-
2006 Campaign: Final Report. Project Number: 20738, 002/2006. Unpublished study
prepared by E. I. Du Pont de Nemours and Co., Inc. and Microquim S.A. 41 p.
46979934 Ruhl, J.; Cornwell, G.; Hammond, T.; et al. (2006) Magnitude of Chlorantraniliprole
(DPX-E2Y45) Residues in Fruit and Vegetable Commodities (Peach, Grape, Tomato,
and Head Lettuce) and Cotton Commodities Following Foliar Applications of
Chlorantranilprole 35WG orChlorantranilprole 20SC -Australia, 2004-5 or 2005-6.
Project Number: 20921AU. Unpublished study prepared by E. I. Du Pont de Nemours
and Co., Inc. 156 p.
46979935 Munley, S. (2006) DPX-E2Y45: Repeated-Dose Oral Toxicity 2-Week Gavage Study
in Rats with Metabolism and Genetic Toxicology. Project Number: 20977, 13867,
1583. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 227 p.
46979936 Stry, J. (2006) Validation of Multi-Residue Method DFG S 19 (L 00.00-34) for the
Determination of Residues of DPX-E2Y45 in Different Animal Matrices with LC-
MS/MS Detection. Project Number: 20979. Unpublished study prepared by E. I. Du
Pont de Nemours and Co., Inc. 42 p.
46979937 Vaughn, A.; Ruhl, J. (2006) Relevance of U.S. Magnitude of Residue Study for DPX-
E2Y45 on Leafy Vegetables Crop Group to Canadian Conditions. Project Number:
21035. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 8 p.
46979938 Platz, S. (2006) Determination of DPX-E2Y45 in Technical Grade DPX-E2Y45.
Project Number: 21219. Unpublished study prepared by E. I. Du Pontde Nemours
and Co., Inc. 33 p.
46979939 Stanley, B. (2006) DPX-E2Y45: Prospective Population Modeling of Collembolan
Responses to Potential Exposures in Soil. Project Number: 21352EU. Unpublished
study prepared by E. I. Du Pont de Nemours and Co., Inc. 43 p.
46979940 Stanley, B. (2006) DPX-E2Y45: Prospective Population Modeling of Daphnia magna
Responses to Potential Exposures in Water. Project Number: 21353/EU. Unpublished
study prepared by E. I. Du Pont de Nemours and Co., Inc. 46 p.
46979941 Donner, E. (2006) DPX-E2Y45 Technical: Subchronic Toxicity 28-Day Feeding Study
in Rats, Revision Number 1. Project Number: 14033, 880, 9523. Unpublished study
prepared by E. I. Du Pont de Nemours and Co., Inc. 287 p.
46979942 Donner, E. (2006) DPX-E2Y45 Technical: Subchronic Toxicity 28-Day Feeding Study
in Rats, Supplement Number 1. Project Number: 9523, 14033, 880. Unpublished
study prepared by E. I. Du Pont de Nemours and Co., Inc. 12 p.
46979943 Wang, W. (2006) Determination of DPX-E2Y45 in DPX-E2Y45 Formulation End-Use
Products - Reversed-Phase Liquid Chromatographic Assay Method: Revision
Number 1. Project Number: E2Y45/220/03/ST. Unpublished study prepared by E. I.
Du Pont de Nemours and Co., Inc. 26 p.
46979944 Dorschner, K. (2006) E2Y45: Magnitude of the Residue on Grape. Project Number:
09388/05/NY15, 09388/05/NJ23, 09388/05/CA123. Unpublished study prepared by
IR-4; See Interregional Research Project and Agricultural Chemistry Development
66
-------
Services, Inc. (ACDS) and Attaway Field Research. 271 p.
46979945 Dorschner, K. (2006) E2Y45: Magnitude of the Residue on Peach. Project Number:
ONY169389/05/, 09389/05/NJ24, 09389/05/NJ25. Unpublished study prepared by IR-
4; See Interregional Research Project, Reality Research and Michigan State
University. 249 p.
46979946 Freudenberger, J.; McNally, M. (2007) Chlorantraniliprole (DPX-E2Y45) Active
Substance Confidential Manufacturing Information - Specifications and Summaries
(Document J - Part 1). Project Number: 19472. Unpublished study prepared by E. I.
Du Pont de Nemours and Col, Inc. 54 p.
46979947 Roche, R. (2006) Chlorantraniliprole 20SC (DPX-E2Y45 20SC) 200 G/L Suspension
Concentrate Formulation; Specifications and Information on Formulation Ingredients
(Document J - Part 3) (Information from Documents G, H, and I). Project Number:
19495. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 81 p.
46979948 Pugh, L. (2006) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-Dispersible
Granular Formulation; Specifications and Information on Formulation Ingredients
(Document J - Part 3) (Information from Documents G, H, and I). Project Number:
19510. Unpublished study prepared by E. I. Du Pont de Nemours and Co., Inc. 79 p.
46980000 E.I. du Pont de Nemours & Co. (2007) Submission of Product Chemistry, Toxicity,
Residue, Efficacy and Fate Data in Support of the Applications for Registration of
DuPont Rynaxypyr Technical, DuPont E2Y45 SC, DuPont Altacor WG, and DuPont
Coragen SC Insecticide, and the Petition for Tolerance of DPX-E2Y45 on Apples,
Lettuce, Peaches, Pears, Tomatoes, Plum, Cherries, Broccoli, Cauliflower, Mustard,
Greens, Cabbage, Cucumber, Summer Squash, Cantaloupe, Bell Pepper, Celery,
and Spinach. Transmittal of 10 Studies.
46980002 Allin, J.; Bassi, A.; Marmor, F. (2007) Chlorantraniliprole 20SC (DPX-E2Y45 20SC)
200G/L Suspension Concentrate Formulation A New Insecticide for Lepidoptera and
Coleoptera Control. Efficacy and Crop Safety Data to Support Application in Potato
Crops and Pome Fruit.. Project Number: 21346. Unpublished study prepared by E. I.
du Pont de Nemours and Co., Inc. 350 p.
46980003 Alam, S.; Vaughan, C.; Marmor, W. (2007) Biological Assessment Dossier for DPX-
E2Y45 35 WG Canada, 2007. Project Number: DUPONT/21701. Unpublished study
prepared by E. I. du Pont de Nemours and Co, Inc. 1052 p.
46980004 Alam, S.; Vaughan, C.; Marmor, F. (2007) Biological Assessment Dossier For DPX-
E2Y45 20SC-Canada, 2007. Project Number: 21702. Unpublished study prepared by
E. I. du Pont de Nemours and Co, Inc. 664 p.
46980005 Hammond, T.; Cornwell, G.; Mitchell, G.; et al. (2007) Chlorantraniliprole (DPX-
E2Y45) DPX-E2Y45 20SC 200G/L Suspension Concentrate Formulation Biological
Assessment Dossier For DPX-E2Y45 20SC in Vegetables-Australia, 2007. Project
Number: DUPONT/21856. Unpublished study prepared by E. I. du Pontde Nemours
and Co, Inc. 796 p.
46980006 Hammond, T.; Mitchell, G.; Marmor, F. (2007) Chlorantraniliprole (DPX-E2Y45) DPX-
E2Y45 350G/KG Water Dispersible Granule Formulation Biological Assessment
Dossier for DPX-E2Y45 35WG in Fruit Crops - Australia, 2007. Project Number:
DUPONT/21857. Unpublished study prepared by E. I. du Pont de Nemours and Co,
Inc. 719 p.
46980007 Cornwell, G.; Mitchell, G.; Marmor, F. (2007) Chlorantraniliprole (DPX-E2Y45) DPX-
E2Y45 35WG 350 G/KG Water Dispersible Granule Formulation Biological
Assessment Dossier For DPX-E2Y45 35WG In Cotton -Australia, 2007. Project
Number: DUPONT/21858. Unpublished study prepared by E. I. du Pontde Nemours
And Co, Inc. 593 p.
67
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46980008 Ridley, P.; Mitchell, G. (2007) Chlorantraniliprole (DPX-E2Y45) DPX-E2Y45 20SC
200G/L Suspension Concentrate Formulation Biological Assessment Dossier For
DPX-E2Y45 20SC In Turf-Australia, 2007. Project Number: DUPONT/21859.
Unpublished study prepared by E. I. du Pont de Nemours And Co, Inc. 320 p.
46980009 Schur, A. (2006) DPX-E2Y45-105: A Semi-Field Study (Non-GLP) to Evaluate Effects
on the Honey Bee (Apis mellifera carnica; Hymenoptera, Apidae) in Phacelia in 2003:
Final Report. Project Number: DUPONT/12753, 20031181/F1/BZEU, 14622.
Unpublished study prepared by E. I. du Pont de Nemours and Co, Inc. 47 p.
46980010 Carver, R. (2007) Reduced Risk Rationale for Use of DPX-E2Y45 on Apples, Lettuce,
Peaches, Pears, Tomatoes, and Turf. Project Number: DUPONT/20218. Unpublished
study prepared by E. I. du Pont de Nemours and Co, Inc. 194 p.
46991000 E. I. DuPont De Nemours and Co. (2006) Submission of Product Chemistry Data in
Support of the Experimental Use of DuPont Altacor Insecticide and Dupont Coragen
Insecticide. Transmittal of 3 Studies.
46991001 Craig, W. (2004) DPX-E2Y45: Laboratory Study of UV/Visible Absorption and Molar
Absorptivity. Project Number: 13167, 343626. Unpublished study prepared by
Inveresk. 37 p.
46991002 Pugh, L. (2006) Product Identity and Compostion of End-Use Product DPX-E2Y45 35
WG. Project Number: 20181. Unpublished study prepared by E. I. du Pontde
Nemours & Co. 56 p.
46991003 Roche, R. (2006) Product Identity and Compostion of End-Use Product DPX-E2Y45
200 g/L SC. Project Number: 20181. Unpublished study prepared by E. I. Du Pont de
Nemours and Co. 77 p.
47051700 E.I. Du Pontde Nemours & Co. Inc. (2007) Submission of Product Chemistry and
Exposure and Risk Data in Support of the Applications for Registration of DuPont
E2Y45 0.133G Insecticide plus Fertilizer, 0.1G Insecticide plus Fertilizer, 0.067G
Insecticide plus Fertilizer, 0.05G Insecticide plus Fertilizer and 0.1G Lawn & Garden
Insecticide plus Fertilizer. Transmittal of 3 Studies.
47051701 Finlay, C. (2007) DPX-E2Y45-292 0.133 GR: Acute Eye Irritation Study in Rabbits.
Project Number: 21082, 17023, 602. Unpublished study prepared by E. I. Du Pont De
Nemours & Co. Inc. 22 p.
47051702 Bloemer, D. (2007) DPX-E2Y45 Granular (Fertilizer) Insecticide Formulation (0.133%
A.I. Content): Laboratory Study of Physical and Chemical Properties. Project Number:
DUPONT/21214. Unpublished study prepared by E. I. Du Pont De Nemours and Co.
Inc. 10 p.
47051703 Brown, P. (2006) Product Identity and Compositon of End-Use Product DPX-E2Y45
0.133 Granular Fertilizer Insecticide. Project Number: DUPONT/21302. Unpublished
study prepared by E. I. Du Pont De Nemours and Co. Inc. 56 p.
47051800 Dupont Crop Protection (2007) Submission of Product Chemistry and Risk Data in
Support of the Applications for Registration of Dupont E2Y45 0.33G Insecticide,
0.25G Insecticide, 0.167G Insecticide, 0.125G Insecticide, 0.16G Lawn & Garden
Insecticide, 0.12G Lawn & Garden Insecticide, 0.08G Lawn & Garden Insecticide,
0.05G Lawn & Garden Insecticide, and Manufacturing Concentrate. Transmittal of 3
Studies.
47051801 Mullin, L. (2007) Occupational Handler Risk Assessment for DPX-E2Y45 Granular
Formulations on Turf and Landscape Ornamentals. Project Number: DUPONT/18982.
Unpublished study prepared by Dupont Haskell Laboratory. 20 p.
47051802 Bloemer, D. (2007) DPX-E2Y45 Granular (Volclay) Insecticide Formulation (0.33%
68
-------
A.I. Content): Laboratory Study of Physical and Chemical Properties. Project Number:
DUPONT/21211. Unpublished study prepared by Dupont Haskell Laboratory. 10 p.
47051803 Brown, P. (2006) Product Identity and Composition of End-Use Product DPX-E2Y45
0.33 Granular Insecticide. Project Number: DUPONT/21301. Unpublished study
prepared by Dupont Haskell Laboratory. 8 p.
47053500 Dupont Crop Protection. (2007) Submission of Product Chemistry Data in Support of
Registration of Chlorantraniliprole. Transmittal of 1 Study.
47053501 Malley, L. (2002) Neurotoxicity Evaluation of Carbaryl and Scopolamine in Rats
(Positive Control Study). Project Number: 7378, 13795, 1270. Unpublished study
prepared by: E. I. du Pont de Nemours and Co, Inc. 108 p.
47067200 E.I. du Pont de Nemours and Co. (2007) Submission of Product Chemistry and
Toxicity Data in Support of the Application for Registration of Dupont Rynaxypyr
Technical and the Petition for Tolerance of DPX-E2Y45. Transmittal of 1 Study.
47067201 Carver, R. (2007) Response to EPA Reviewer Questions on the Manufacturing
Process Used for Preparation of Chlorantraniliprole Toxicology Test Materials. Project
Number: 22621. Unpublished study prepared by E. I. du Pont de Nemours and Co
Inc. 20 p.
47076200 E.I. du Pont de Nemours and Co. Inc. (2007) Submission of Product Chemistry Data
in Support of the Applications for Registration of DuPont E2Y45 0.16G, 0.12G, 0.08G,
and 0.05G Lawn and Garden Insecticides. Transmittal of 2 Studies.
47076201 Brown, P. (2007) Product Identity and Composition of End Use-Product DPX-E2Y45
0.16 Granular Insecticide. Project Number: 21917, 21603, 000075. Unpublished study
prepared by E. I. du Pone de Nemours and Co Inc. 28 p.
47076202 Bloemer, D. (2007) DPX-E2Y45 Granular (Biodac) Insecticide Formulation (0.16%
A.I. Content): Laboratory Study of Physical and Chemical Properties. Project Number:
21215. Unpublished study prepared by E. I. du Pont de Nemours and Co. Inc. 10 p.
47116400 Du Pont Crop Protection (2007) Submission of Toxicity Data in Support of the
Application for Registration of Dupont Rynaxpyr Technical. Transmittal of 12 Studies.
47116401 Finlay, C. (2006) IN-G2S78: Acute Dermal Toxicity Study in Rats. Project Number:
17880, 16278, 673. Unpublished study prepared by E. I. Du Pont de Nemours and Co
Inc. 37 p.
47116402 Finlay, C. (2006) IN-G2S78: Acute Dermal Irritation Study in Rabbits. Project Number:
17881, 16278, 1008. Unpublished study prepared by E. I. Du Pontde Nemours and
Co. Inc. 24 p.
47116403 Finlay, C. (2006) IN-G2S78: Acute Eye Irritation Study in Rabbits. Project Number:
17888, 16278, 602. Unpublished study prepared by E. I. Du Pont De Nemours and
Co Inc. 23 p.
47116404 Myhre, A. (2006) IN-G2S78: Bacterial Reverse Mutation Test. Project Number:
17895, 16278, 500. Unpublished study prepared by E. I. Du Pont De Nemours and
Co. Inc. 54 p.
47116405 Finlay, C. (2006) IN-G2S78: Acute Oral Toxicity Study in Rats - Up and Down
Procedure. Project Number: 17903, 16278, 834. Unpublished study prepared by E. I.
Du Pont de Nemours and Co. Inc. 29 p.
47116406 Hoban, D. (2006) IN-G2S78: Local Lymph Node Assay (LLNA) in Mice. Project
Number: 17906, 16278, 1234. Unpublished study prepared by E. I. Du Pontde
Nemours and Co. Inc. 37 p.
69
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47116407 Kelly, D. (2006) IN-G2S78: Inhalation Median Lethal Concentration (LC 50) Study in
Rats. Project Number: 16460, 18943, 721. Unpublished study prepared by E. I.
Dupont de Nemours and Co. Inc. 43 p.
47116408 Finlay, C. (2007) IN-E8S90: Acute Oral Toxicity in Rats - Up-and-Down Procedure.
Project Number: 20425, 16781, 834. Unpublished study prepared by E. I. Du Pontde
Nemours and Co. Inc. 29 p.
47116409 Carpenter, C. (2007) IN-E8S90: Acute Dermal Toxicity Study in Rats. Project
Number: 20430, 16781, 673. Unpublished study prepared by E. I. Du Pont de
Nemours and Co Inc. 35 p.
47116410 Finlay, C. (2006) IN-E8S90: Acute Dermal Irritation Study in Rabbits. Project Number:
16781, 1008,20431. Unpublished study prepared by E. I. Du Pontde Nemours and
Co. Inc. 24 p.
47116411 Finlay, C. (2007) IN-E8S90: Acute Eye Irritation Study in Rabbits. Project Number:
20434, 16781, 602. Unpublished study prepared by E. I. Du Pont de Nemours and
Co. Inc. 23 p.
47116412 Hoban, D. (2006) IN-E8S90: Local Lymph Node Assay (LLNA) in Mice. Project
Number: 20437, 16781, 1234. Unpublished study prepared by E. I. Du Pont de
Nemours and Co. Inc. 36 p.
47124100 Dupont Crop Protection (2007) Submission of Product Chemistry Data in Support of
the Application for Registration of DuPont Rynaxapyr Technical. Transmittal of 1
Study.
47124101 Cordova, D.; Tao, Y. (2007) Molecular Basis for DPX-E2Y45's Differential Selectivity
Between Insect and Mammalian Ryanodine Receptors. Project Number: 23134.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 11 p.
47125400 DuPont Crop Protection (2007) Submission of Toxicity Data in Support of the
Application for Registration of DuPont Rynaxypyr Technical. Transmittal of 1 study.
47125401 Myhre, A. (2006) IN-E8S90: Bacterial Reverse Mutation Test. Project Number:
DUPONT/20441, 16781. Unpublished Study Prepared by E. I . Du Pont De Nemours
and Company. 56 p.
47138400 E.I. du Pontde Nemours and Company (2007) Submission of Fate & Residue Data in
Support of the Applications for Registration of Dupont Coragen SC Insecticide,
DuPont Rynaxypyr Technical Insecticide, DuPont AltacorWG Insecticide and DuPont
E2Y45 SC Insecticide and the Petition for Tolerance of Chlorantraniliprole.
Transmittal of 16 Studies.
47138401 Sharma, A.; Rice, F.; Grant, A. (2007) Terrestrial Field Dissipation of DPX-E2Y45
Insecticide on Bare Soil in Minnesota, 2005, USA. Project Number: 14440, 48925.
Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc, E.I. Du Pont de
Nemours & Co. 232 p.
47138402 Lowrie, C.; Lynn, R.; Coyle, D. (2007) DPX-E2y45: Batch Equilibrium
(Adsorption/Desorption) in Five Soils. Project Number: 14445, 805401. Unpublished
study prepared by Inveresk Research International. 63 p.
47138403 Singles, S.; Rice, F.; Gant, A. (2007) Terrestrial Field Dissipation Of DPX-E2y45
Insecticide On Bare Soil in Prince Edward Island, 2005, Canada. Project Number:
16518, 49638. Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc
and E.I. Du Pont de Nemours & Co., Inc. 187 p.
47138404 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Apples and Pears (Pome Fruit) Following Foliar Applications of DPX-E2Y45 20SC
[200 G A.S./L (W/V); 18.5% (W/W)] - Northern and Southern Europe, 2005. Project
70
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Number: 16577, 687543. Unpublished study prepared by Charles River Laboratories .
134 p.
47138405 Rice, F.; Rodgers, C. (2007) Crop Rotation Study with DPX-E2Y45 20SC Insecticide -
NAFTA Growing Zone 1A, Canada, 2005. Project Number: 17045, 49695.
Unpublished study prepared by Analytical Bio-Chemistry Labs., Inc. 106 p.
47138406 Ruhl, J. (2007) Chlorantraniliprole (DPX-E2Y45) Active Substance. Project Number:
18272. Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 44 p.
47138407 Singles, S. (2007) Chlorantraniliprole (DPX-E2Y45) Active Substance. Project
Number: 18273. Unpublished study prepared by WC D Speciality Mfg Co. 45 p.
47138408 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprofle) Residues in Peaches and Appricots (Stone Fruit) Following
Applications of DPX-E2Y45 20 SC, Southern Europe-2006 Growing Season, and
Subsequent Residue Population Comparability forOECD Workshare C. Project
Number: 20922/EU. Unpublished study prepared by E. I. Du Pont de Nemours and
Co., Inc. 12 p.
47138409 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary Of DPX-E2Y45
(Chlorantraniliprole) Residues in Table And Wine Grapes Following Applications Of
DPX-E2Y45 20SC or DPX-E2Y45 35WG, Europe - 2006 Growing Season, And
Subsequent Residue Population Comparability ForOECD Workshare Consideration.
Project Number: 20923/EU. Unpublished study prepared by E. I. du Pont de Nemours
and Co., Inc. 18 p.
47138410 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprole) Residues in Cucumbers/Courgettes and Melons Following
Applications of DPX-E2Y45 35WG, Europe - 2006 Growing Season, and Subsequent
Residue Population Comparability and MRL Proposals forOECD Worksh. Project
Number: 20924/EU. Unpublished study prepared by E. I. Du Pont De Nemours and
Co., Inc. 21 p.
47138411 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprole) Residues in Peppers Following Applications of DPX-E2Y45
35WG, Europe- 2006 Growing Season, and Subsequent Residue Population
Comparability for OECD Workshare Consideration. Project Number: 20925/EU.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 18 p.
47138412 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprole) Residues in Tomatoes Following Applications of DPX-E2Y45
20SC or DPX-E2Y45 35WG, Europe - 2006 Growing Season, and Subsequent
Residue Population Comparability for OECD Workshare Consideration. Project
Number: 20926. Unpublished study prepared by E. I. Du Pont De Nemours and Co.,
Inc. 17 p.
47138413 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprole) Residues in Lettuce Following Applications of DPX-E2Y45
35WG, Europe - 2006 Growing Season, and Subsequent Residue Population
Comparability and MRL Proposals for OECD Workshare Consideration. Project
Number: 20927/EU. Unpublished study prepared by E. I. Du Pont De Nemours and
Co., Inc. 22 p.
47138414 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
(Chlorantraniliprole) Residues in Potato Tubers Following Applications of DPX-E2Y45
20SC, Europe - 2006 Growing Season, and Subsequent Residue Population
Comparability for OECD Workshare Consideration. Project Number: 20928.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 9 p.
47138415 Bookhart, S.; Kennedy, C.; Ruhl, J. (2007) Summary of DPX-E2Y45
71
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(Chlorantraniliprole) Residues in Apples and Pears (Pome Fruit) Following
Applications of DPX-E2Y45 20SC, Europe - 2006 Growing Season, and Subsequent
Residue Population Comparability for OECD Workshare Condiseration. Project
Number: 20929/EU. Unpublished study prepared by E. I. Du Pont De Nemours and
Co., Inc. 12 p.
47138416 Huber, A. (2007) Kinetic Sorption of DPX-E2Y45 in Laboratory and Field Soils-A
Mobilling Study with Pearlneq Pest and Focus Pearl 2.2.2. Project Number: 20930.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 199 p.
47189000 E.I. du Pont de Nemours and Co. (2007) Submission of Residue, Product Chemistry
Data and Toxicity Data in Support of the Applications for Registration of Rynaxpyr
Technical Insecticide, Coragen SC Insecticide, Altacor WG Insecticide, and E2Y45
SC Insecticide. Transmittal of 5 Studies.
47189001 MacDonald, A.; Paterson, K.; Coyle, D. (2005) The Metabolism of [14-Carbon]-DPX-
E2Y45 in Lettuce: Amendment 1 to Final Report. Project Number: 12265, 804172.
Unpublished study prepared by Inveresk Research International. 73 p.
47189002 Bentley, K. (2007) Chlorantraniliprole (DPX-E2Y45) Active Substance: Mamallian
Toxicology. Project Number: 18271. Unpublished study prepared by E. I. Du Pont De
Nemours and Co., Inc. 15 p.
47189003 Gaddamidi, V. (2007) Chlorantraniliprole (DPX-E2Y45) Active Substance: Residue
Chemistry. Project Number: 18272. Unpublished study prepared by E. I. du Pont de
Nemours and Co. Inc. 10 p.
47189004 Cosgrave, T. (2007) Chlorantraniliprole 35WG (DPX-E2Y45 35WG) Water-
Dispersible Granular Formulation: Identity of the Plant Product, Physical, Chemical
and Technical Properties of the Plant Protection Product. Project Number: 19504.
Unpublished study prepared by E. I. Du Pont De Nemours and Co., Inc. 20 p.
47189005 Bloemer, D. (2007) DPX-E2Y45 35WG Water-Dispersible Granular Insecticide
Formaulation: Laboratory Study of Physical and Chemical Properties. Project
Number: 21537. Unpublished study prepared by E. I. du Pont de Nemours and Co.
Inc. 15 p.
47197200 E.I. du Pont de Nemours and Co., Inc. (2007) Submission of Toxicity Data in Support
of the FIFRA 6(a)(2) Data Requirements for DuPont Rynaxypyr Technical. Transmittal
of 1 Study.
47197201 Hoban, D. (2007) DPX-E2Y45 Technical (DPX-E2Y45-282): Local Lymph Node
Assay (LLNA) in Mice. Project Number: DUPONT/20295, 16722, 1234. Unpublished
study prepared by Dupont Haskell Laboratory and Critical Path Services, LLC. 63 p.
47231200 E.I. du Pont de Nemours and Co., Inc. (2007) Submission of Product Chemistry,
Efficacy, Fate, Toxicity, Environmental Fate, Residue, Exposure and Risk Data in
Support of the Applications for Registration of DuPont Rynaxypyr Technical
Insecticide, Dupont Coragen SC Insecticide, Dupont Altacor WG Insecticide and
Dupont E2Y45 SC Insecticide and the Petition for Tolerance of Chlorantraniliprole.
Transmittal of 29 Studies.
47231201 Gannon, S. (2007) DPX-E2Y45 Technical: 90-Day Oral Toxicity Study in Dogs.
Project Number: 14513, 1319, 125/049. Unpublished study prepared by MPI
Research, Inc. 23 p.
47231202 Munley, S. (2007) DPX-E2Y45 Technical: 28 - Day Immunotoxicity Feeding Study in
Mice. Project Number: 14354, 15207, 1546. Unpublished study prepared by E. I. Du
Pont de Nemours and Co., Inc. 78 p.
47231203 Huber, A. (2007) Predicted Concentrations of DPX-E2Y45 and Its Metabolites in
72
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Surface Waters in Europe - A Modeling Study Conducted with Focus Surface Water
Scenarios. Project Number: 16523. Unpublished study prepared by DuPontde
Nemours (Deutschland) GmbH. 175 p.
47231204 Huber, A. (2007) Leaching Behaviour of DPX-E2Y45 and its Metabolities - A
Modeling Study with Focus Pelmo 3.3.2 and Focus Pearl 3.3.3. Project Number:
16524. Unpublished study prepared by DuPont de Nemours (Deutschland) GmbH.
117p.
47231205 Fraser, G.; Kinney, J. (2007) Storage Stability of DPX-E2Y45, IN-HXH44, IN-K9TOO,
IN-GAZ70 and IN-EQW78 in Cattle Tissus and Milk Stored Frozen. Project Number:
17004, 209269, 26862. Unpublished study prepared by Charles River Laboratories.
265 p.
47231206 Bentley, K. (2007) Chlorantraniliprole (DPX-E2Y45): Mammalian Toxicology. Project
Number: 18271. Unpublished study prepared by E. I. Du Pont De Nemours and Co.,
Inc. 9 p.
47231207 Ruhl, J. (2007) Chlorantraniliprole (DPX-E2Y45): Residue Chemistry. Project
Number: 18272. Unpublished study prepared by E. I. Du Pont De Nemours and Co.,
Inc. 31 p.
47231208 Foster, A.; Cairns, S. (2007) Magnitude of DPX-E2Y45 Residues in Potatoes (Potato
Group) Following Foliar Applications of DPX-E2Y45 20SC [200 G A.S./L (W/V);
18.5% (W/W)] - Northern and Southern Europe, 2006. Project Number: 18748,
689561. Unpublished study prepared by Charles River Laboratories and Agrolab S.A.
81 p.
47231209 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Peaches and Apricots (Stone Fruit) Following Foliar Applications of DPX-E2Y45 20
SC [200 G A.S./L (W/V); 18.5% (W/W)] - Southern Europe, 2006. Project Number:
18749, 689666, 0673. Unpublished study prepared by Charles River Laboratories and
Agrolab - Sindos Analytical Laboratories. 104 p.
47231210 Foster, A.; Cairns, S.; Hansford, R. (2007) Magnitude and Decline of DPX-E2Y45
Residues in Field Lettuce (Leaf Vegetables) Following Foliar Applications of DPX-
E2Y45 35WG - France and Southern Europe, 2006. Project Number: 18750, 689582.
Unpublished study prepared by Charles River Laboratories, Agrisearch France SARL
and Agrolab - Sindos Analytical Laboratories. 115 p.
47231211 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Table Grapes (Berries and Small Fruit) Following Foliar Applications of DPX-E2Y45
20 SC [200 G A.S./L (W/V); 18.5% (w/w)] and DPX-E2Y45 35 WG Formulated
Products - Southern Europe 2006. Project Number: 18751, 689645. Unpublished
study prepared by Charles River Laboratories, ARA Sperimentazioni in Agricultura
and Agrolab - Sindos Analytical Laboratories. 106 p.
47231212 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Apples and Pears (Pome Fruit) Following Foliar Application of DPX-E2Y45 20 SC
[200 G A.S./L (W/V); 18.5% (W/W)] - Northern and Southern Europe 2006. Project
Number: 18752, 689650, 0673. Unpublished study prepared by Charles River
Laboratories and Agrolab - Sindos Analytical Laboratories. 107 p.
47231213 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in Field
Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications of DPX-
E2Y45 35WG - Southern Europe 2006 . Project Number: 18753, 689619, 0673.
Unpublished study prepared by Charles River Laboratories and Agrolab - Sindos
Analytical Laboratories. 89 p.
47231214 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications of
73
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DPX-E2Y45 35WG - Europe 2006. Project Number: 18754, 689624, 0673.
Unpublished study prepared by Charles River Laboratories. 90 p.
47231215 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Tomatoes (Fruiting Vegetables, Solanacea) Following Foliar Applications of
DPX-E2Y45 35WG - Europe, 2006. Project Number: 18755, 689598, 0673.
Unpublished study prepared by Charles River Laboratories. 89 p.
47231216 Foster, A.; Cairns, S. (2006) Magnitude and Decline of DPX-E2Y45 Residues in Field
Tomatoes (Fruiting Vegetables, Solanacea) Following Foliar Applications of DPX-
E2Y45 20SC [200 G A.S./L (w/v); 18.5% (w/w)] and DPX-E2Y45 35WG Formulated
Products - Southern Europe 2006. Project Number: DUPONT/18756, 689603.
Unpublished study prepared by Charles River Laboratories. 94 p.
47231217 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Hot Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications
of DPX-E2Y45 35WG - Europe, 2006. Project Number: DUPONT/18757, 689713.
Unpublished study prepared by Charles River Laboratories and Agrolab - Sindos
Analytical Laboratories. 86 p.
47231218 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Cucumbers and Courgettes (Fruiting Vegetables, Edible-Peel Cucurbits)
Following Foliar Applications of DPX-E2Y45 35WG - Europe, 2006. Project Number:
DUPONT/18760, 689671. Unpublished study prepared by Charles River Laboratories
and Agrolab - Sindos Analytical Laboratories and Agroplan. 124 p.
47231219 Foster, A.; Cairns, S.; Hansford, R. (2007) Magnitude and Decline of DPX-E2Y45
Residues in Protected Melons (Fruiting Vegetables, Inedible-Peel Cucurbits)
Following Foliar Applications of DPX-E2Y45 35WG - Europe, 2006. Project Number:
DUPONT/18761, 689687. Unpublished study prepared by Charles River
Laboratories, Agrolab - Sindos Analytical Laboratories and Agroplan. 150 p.
47231220 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Lettuce Including Lambs Lettuce (Leaf Vegetables) Following Foliar
Applications of DPX-E2Y45 35WG - Europe, 2006. Project Number: DUPONT/18764,
689708. Unpublished study prepared by Charles River Laboratories, Agrolab - Sindos
Analytical Laboratories and Agroplan. 174 p.
47231221 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in Field
Hot Peppers (Fruiting Vegetables, Solanacea) Following Foliar Applications of DPX-
E2Y45 35WG - Southern Europe, 2006. Project Number: DUPONT/18765, 689734.
Unpublished study prepared by Charles River Laboratories. 89 p.
47231222 Foster, A.; Cairns, S. (2007) Magnitude and Decline of DPX-E2Y45 Residues in
Protected Cherry Tomatoes (Fruiting Vegetables, Solanacea) Following Foliar
Applications of DPX-E2Y45 35WG - Europe, 2006. Project Number: DUPONT/18769,
689729. Unpublished study prepared by Charles River Laboratories. 81 p.
47231223 Huber, A. (2007) Predicted Concentrations of DPX-E2Y45 and Its Metabolites IN-
EQW78, IN-ECD73, IN-F6L99, IN-GAZ70, and IN-F9N04 in Soil. Project Number:
DUPONT/18937. Unpublished study prepared by E.I. DuPontde Nemours and
Company. 77 p.
47231224 Foster, A.; Cairns, S.; Hansford, R. (2007) Magnitude and Decline of DPX-E2Y45
Residues in Wine Grapes (Berries and Small Fruit) Following Foliar Applications of
DPX-E2Y45 20SC [200 G A.S./L (w/v); 18.5% (w/w)] - Northern and Southern Europe
2006. Project Number: DUPONT/19306, 689577. Unpublished study prepared by
Charles River Laboratories. 160 p.
47231225 Huber, A.; Singles, S. (2007) Chlorantraniliprole 20SC (DPX-E2Y45 20SC): 200 G/L
Suspension Concentrate Formulation: Annex IMA: Section 5: Fate in the Environment:
74
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Summaries and Assessment (Tier II - Document M-lll): Revision No. 1. Project
Number: DUPONT/19493. Unpublished study prepared by E.I. DuPontde Nemours
and Company. 140 p.
47231226 Brugger, K.; Dinter, A. (2007) Chlorantraniliprole 20SC (DPX-E2Y45 20SC): 200 G/L
Suspension Concentrate Formulation: Annex IMA: Section 6: Ecotoxicology:
Summaries and Assessment (Tier II - Document M-lll): Revision No. 1. Project
Number: DUPONT/19494. Unpublished study prepared by E.I. DuPontde Nemours
and Company. 302 p.
47231227 Frost, N.; McNally, M.; Stry, J.; et al. (2007) Chlorantraniliprole (DPX-E2Y45): Active
Substance and Plant Protection Products DPX-E2Y45 20SC and DPX-E2Y45 35WG:
Overall Summary and Assessment (Tier III - Document N): Revision No. 1. Project
Number: DUPONT/19496. Unpublished study prepared by E.I. DuPontde Nemours
and Company. 327 p.
47231228 Huber, A.; Singles, S. (2007) Chlorantraniliprole 35WG (DPX-E2Y45 35WG): Water-
Dispersible Granular Formulation: Annex IMA: Section 5: Fate in the Environment:
Summaries and Assessment (Tier II - Document M-lll): Revision No. 1. Project
Number: DUPONT/19508. Unpublished study prepared by E.I. DuPontde Nemours
and Company. 109 p.
47231229 Brugger, K.; Dinter, A. (2007) Chlorantraniliprole 35WG (DPX-E2Y45 35WG): Water-
Dispersible Granular Formulation: Annex IMA: Section 6: Ecotoxicology: Summaries
and Assessment (Tier II - Document M-lll): Revision No. 1. Project Number:
DUPONT/19509. Unpublished study prepared by E.I. DuPont de Nemours and
Company. 280 p.
47252000 E.I. du Pont de Nemours and Co. (2007) Submission of Residue Data in Support of
the Application for Registration of DuPont Alcator WG Insecticide and the Petition for
Tolerance of Dupont Alcator WG Insecticide for Use on Tree Nuts, Almond Hulls and
Pistachios. Transmittal of 1 Study.
47252001 Shepard, E. (2007) Magnitude of DPX-E2Y45 Residues in Tree Nuts (Almond and
Pecan) Following Foliar Applications of DPX-E2Y45 35WG - US, 2006. Project
Number: 18803, 50072. Unpublished study prepared by ABC Laboratories Inc. and
Access Research and Consulting, Inc. 138 p.
47255700 E. I. du Pont de Nemours and Co. (2007) Submission of Residue Data in Support of
the Petition for Tolerance of Chlorantraniliprole for Use on Fruit Crops, Cotton,
Grapes and Vegetables. Transmittal of 1 Study.
47255701 Klemens, A.; Barefoot, A.; Bentley, K.; et al. (2007) Human Risk Assessments in
Support of Tolerance Exemption for Chlorantraniliprole (DPX-E2Y45) in the United
States. Project Number: 24031/US. Unpublished study prepared by E. I. du Pont de
Nemours and Co. 13 p.
47301800 E. I. du Pont de Nemours and Co., Inc. (2007) Submission of Product Chemistry Data
in Support of the Applications for Registration of Dupont E2Y45 0.16G Lawn &
Garden Insecticide, Dupont E2Y45 0.12G Lawn & Garden Insecticide, Dupont E2Y45
0.08G Lawn & Garden Insecticide, Dupont E2Y45 0.05G Lawn & Garden Insecticide,
Dupont E2Y45 0.33G Insecticide, Dupont E2Y45 0.25G Insecticide, Dupont E2Y45
0.167G Insecticide, Dupont E2Y45 0.125G Insecticide, Dupont E2Y45 0.133G
Insecticide Plus Fertilizer, Dupont E2Y45 0.1G Insecticide Plus Fertilizer, Dupont
E2Y45 0.067G Insecticide Plus Fertilizer, Dupont E2Y45 0.05G Insecticide Plus
Fertilizer, and Dupont E2Y45 0.1G Lawn & Garden Insecticide Plus Fertilizer.
Transmittal of 1 Study.
47301801 Theodorakis, S. (2007) Analytical Method for DPX-E2Y45 Granular Formulations.
Project Number: DUPONT/24162. Unpublished study prepared by DuPont Crop
75
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Protection. 29 p.
47309800 DuPont Crop Protection (2007) Submission of Residue Data in Support of the
Applications for Registration of DuPont Rynaxypyr Technical, DuPont Altacor WG
Insecticide, DuPont Coragen SC Insecticide and DuPont E2Y45 SC Insecticide.
Transmittal of 5 Studies.
47309801 Ruhl, J. (2007) Request for Waiver from the Requirement for Residue Bridging Trials
Between Chlorantraniliprole 200SC and Chlorantraniliprole 35WG. Project Number:
DUPONT/24403. Unpublished study prepared by Dupont Haskell Laboratory. 22 p.
47309802 Ruhl, J. (2007) Request to Lower the Minimum Allowed Spray Volumes for Orchard
Treatment. Project Number: DUPONT/24495. Unpublished study prepared by Dupont
Crop Protection. 30 p.
47309803 Oakes, T. (2007) Chlorantraniliprole (SYN545170): DPX-E2Y45 - Magnitude of the
Residues in or on Tomato: Final Report. Project Number: T004053/06,
ML07/1354/SYN. Unpublished study prepared by Morse Laboratories, Inc., MDS
Harris and Agvise Research. 76 p.
47309804 Oakes, T. (2007) Chlorantraniliprole (SYN545170): DPX-E2Y45 - Magnitude of the
Residues in or on Mustard Greens: Final Report. Project Number: T004054/06,
ML07/1355/SYN. Unpublished study prepared by Morse Laboratories, Inc., Syngenta
Crop Protection and South Texas Ag Research, Inc. 76 p.
47309805 Oakes, T. (2007) Chlorantraniliprole (SYN545170): DPX-E2Y45 - Magnitude of the
Residue in or on Leaf Lettuce: Final Report. Project Number: T004055/06,
ML07/1356/SYN. Unpublished study prepared by Morse Laboratories, Inc., Syngenta
Crop Protection and South Texas Ag Research, Inc. 75 p.
47326300 E.I. du Pont de Nemours and Company (2008) Submission of Toxicity Data in
Support of the Registration of the DPX-E2Y45. Transmittal of 1 Study.
47326301 Smith, A. (2008) Acute Inhalation Toxicity Study of Chlorantraniliprole (DPX-E2Y45)
50FS [50% (w/w)] in Albino Rats: Revised Final Report. Project Number:
DUPONT/23516, 17421, 721. Unpublished study prepared by Wil Research
Laboratories, Inc. 84 p.
47326400 E. I. du Pont de Nemours and Co., Inc. (2008) Submission of Product Chemistry and
Toxicity Data in Support of the Registration of Dupont DermacorX-100 Seed
Treatment. Transmittal of 6 Studies.
47326401 Bloemer, D. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)] End-Use
Product Seed Treatment: Laboratory Study of Physical and Chemical Characteristics.
Project Number: DUPONT/23317/REVISION/NO/1. Unpublished study prepared by
E.I. Du Pont de Nemours and Co. 10 p.
47326402 Carpenter, C. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)]: Local Lymph
Node Assay (LLNA) in Mice. Project Number: 1234, 17421, DUPONT/23517.
Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 37 p.
47326403 Carpenter, C. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)]: Acute Eye
Irritation Study in Rabbits. Project Number: DUPONT/23518, 17421, 602.
Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 22 p.
47326404 Carpenter, C. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)]: Acute Dermal
Irritation Study in Rabbits. Project Number: 1008, 17421, DUPONT/23519.
Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc. 23 p.
47326405 Carpenter, C. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)]: Acute Dermal
Toxicity Study in Rats. Project Number: DUPONT/23520, 17421, 673. Unpublished
study prepared by E. I. du Pont de Nemours and Co., Inc. 31 p.
76
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47326406 Carpenter, C. (2007) Chlorantraniliprole (DPX-E2Y45) FS [50% (w/w)]: Acute Oral
Toxicity Study in Rats - Up-and-Down Procedure. Project Number: DUPONT/23521,
17421, 834. Unpublished study prepared by E. I. du Pont de Nemours and Co., Inc.
27 p.
77
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