Ecological Soil Screening Levels
                   for
                Arsenic

              Interim Final
           OSWER Directive 9285.7-62
         U.S. Environmental Protection Agency
      Office of Solid Waste and Emergency Response
           1200 Pennsylvania Avenue, N.W.
              Washington, DC 20460
                  March 2005

-------
This page intentionally left blank

-------
                             TABLE OF CONTENTS


1.0    INTRODUCTION	1

2.0    SUMMARY OF ECO-SSLs FOR ARSENIC	2

3.0    ECO-SSL FOR TERRESTRIAL PLANTS	3

4.0    ECO-SSL FOR SOIL INVERTEBRATES	3

5.0    ECO-SSL FOR AVIAN WILDLIFE	5
      5.1   Avian TRV	5
      5.2   Estimation of Dose and Calculation of the Eco-SSL	5.

6.0    ECO-SSL FOR MAMMALIAN WILDLIFE	8
      6.1   Mammalian TRV	8
      6.2   Estimation of Dose and Calculation of the Eco-SSL	1_3

7.0   REFERENCES 	14
      7.1   General Arsenic References	14
      7.2   References Used for Derivation of Plant and Soil Invertebrate Eco-SSLs	14
      7.3   References Rejected for Use in Derivation of Plant and Soil Invertebrate Eco-SSLs
             	H
      7.4   References Used for Derivation of Wildlife TRVs	27
      7.5   References Rejected for Use in Derivation of Wildlife TRVs  	3J_

-------
                                  LIST OF TABLES


Table 2.1     Arsenic Eco-SSLs (mg/kg dry weight in soil)	2

Table 3.1     Plant Toxicity Data - Arsenic  	4

Table 5.1     Avian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV) -
             Arsenic	6

Table 5.2     Calculation of the Avian Eco-SSLs for Arsenic  	£

Table 6.1     Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value
             (TRV) - Arsenic	9

Table 6.2     Calculation of the Mammalian Eco-SSLs for Arsenic  	13.



                                 LIST OF FIGURES


Figure 2.1    Typical Background Concentrations of Arsenic in U.S. Soils  	3_

Figure 5.1    Avian TRV Derivation for Arsenic	7

Figure 6.1    Mammalian TRV Derivation for Arsenic 	12



                               LIST OF APPENDICES
Appendix 5-1        Avian Toxicity Data Extracted and Reviewed for Wildlife Toxicity
                    Reference Value (TRV) - Arsenic

Appendix 6-1        Mammalian Toxicity Data Extracted and Reviewed for Wildlife Toxicity
                    Reference Value (TRV) - Arsenic

-------
1.0    INTRODUCTION

Ecological Soil Screening Levels (Eco-SSLs) are concentrations of contaminants in soil that are
protective of ecological receptors that commonly come into contact with and/or consume biota
that live in or on soil.  Eco-SSLs are derived separately for four groups of ecological receptors:
plants, soil invertebrates, birds, and mammals. As such, these values are presumed to provide
adequate protection of terrestrial ecosystems. Eco-SSLs are derived to be protective of the
conservative end of the exposure and effects species distribution, and are intended to be applied
at the screening stage of an ecological risk assessment. These screening levels should be used to
identify the contaminants of potential concern (COPCs) that require further evaluation in the
site-specific baseline ecological risk assessment that is completed according to specific guidance
(U.S. EPA, 1997, 1998, and 1999). The Eco-SSLs are not designed to be used as cleanup levels
and the United States (U.S.) Environmental Protection Agency (EPA) emphasizes that it would
be inappropriate to adopt or modify the intended use of these Eco-SSLs as national cleanup
standards.

The detailed procedures used to derive Eco-SSL values are described in separate documentation
(U.S. EPA, 2003). The derivation procedures represent the  collaborative effort of a
multi-stakeholder group consisting of federal, state, consulting, industry, and academic
participants led by the U.S. EPA, Office of Solid Waste and Emergency Response.

This document provides the Eco-SSL values for arsenic and the documentation for their
derivation. This document provides guidance and is designed to communicate national policy on
identifying arsenic concentrations in soil that may present an unacceptable ecological risk to
terrestrial receptors. The document does not, however, substitute for EPA's statutes or
regulations, nor is it a  regulation itself. Thus, it does not impose legally-binding requirements on
EPA, states, or the regulated community, and may not apply to a particular situation based upon
the circumstances of the site. EPA may change this guidance in the future, as appropriate. EPA
and state personnel may use and accept other technically sound approaches,  either on their own
initiative, or at the suggestion of potentially responsible parties, or other interested parties.
Therefore, interested parties are free to raise questions and objections about the substance of this
document and the appropriateness of the application of this document to a particular situation.
EPA welcomes public comments on this document at any time and may consider such comments
in future  revisions of this document.
Eco-SSL for Arsenic                           1                                  March 2005

-------
2.0    SUMMARY OF ECO-SSLs FOR ARSENIC

Arsenic is naturally present in rock and soils with concentrations in soils reflecting the geology
of the region as well as anthropogenic inputs.  Higher concentrations are associated with igneous
and sedimentary rocks, particularly with sulfidic ores (API, 1998). Extensive discussions of the
sources, concentrations, and chemical species are presented in API (1998) and Cullen and
Reimer(1989).

Arsenic is used in multiple manufacturing and industrial processes including the production of
wood treating chemicals, herbicides, pesticides, desiccants, metal alloys, glass, pharmaceuticals,
and semi-conductors.  Elevated arsenic soil concentrations are often associated with mining
activities, smelters, pesticide/herbicide manufacturing facilities and agricultural lands (API,
1998).

Arsenic can exist in four oxidation states: +5,  +3, 0 and -3. In soil, arsenic is a constituent of
numerous minerals and is found frequently associated with sulfur, most commonly as
arsenopyrite (FeAsS). Inorganic arsenate can also be bound to iron and aluminum cations, or
any other cation that may be present (e.g., calcium, zinc, magnesium, lead) as well as organic
matter in soils (API, 1998).

Arsenic occurs in contaminated soils primarily as the inorganic arsenic (V) and arsenic (III) but
soil microorganisms can produce organic forms (Cullen and Reimer, 1989; Huang, 1994;
CCME, 1996).  Transformations among inorganic and organic forms are controlled by the
oxidation-reduction, precipitation/adsorption,  and biomethylation processes in addition to the
biological production and volatilization of the arsines (API,  1998).  The availability or solubility
of arsenic in soils depends on the source (natural vs. anthropogenic) and the soil's clay content,
redox potential, and pH. Generally, factors that tend to increase arsenic availability are
anthropogenic sources (e.g., pesticides), low clay content, low redox potential (reducing
conditions), and high pH (alkaline conditions) (Cullen and Reimer, 1989, API, 1998).

The Eco-SSL values derived to date for arsenic are summarized in Table 2.1.
Table 2.1 Arsenic Eco-SSLs (mg/kg dry weight in soil)
Plants
18
Soil Invertebrates
NA
Wildlife
Avian
43
Mammalian
46
NA = Not Available. Data were insufficient to derive an Eco-SSL.
Eco-SSL values for arsenic were derived for plants, avian wildlife, and mammalian wildlife. An
Eco-SSL value for arsenic for soil invertebrates could not be derived as data were insufficient.
The Eco-SSLs range from 18 mg/kg dry weight (dw) for plants to 46 mg/kg dw for avian
wildlife. These concentrations are higher than the reported range of background
Eco-SSL for Arsenic
March 2005

-------

25 -

•a 20 -
Bf
a 15~
O 10 -
5 -

X




1
•





x «— MB™,
HE
U ^ 	 25th



X
T
•
l
1
East
West
                                                   Typical Background Concentrations of
                                                   Arsenic in U.S. Soils.
soil concentrations in eastern and
western U.S. soils (Figure 2.1).
Background concentrations of many
metals in U.S. soils are described in
Attachment 1-4 of the Eco-SSL guidance
(U.S. EPA, 2003).
3.0    ECO-SSL FOR
       TERRESTRIAL PLANTS

Of the papers identified from the
literature search process, 171 were       Figure 2.1
selected for acquisition for further
review.  Of those papers  acquired, 26
met all 11 Study Acceptance Criteria (U.S. EPA 2003; Attachment 3-1).  Each of these papers
was reviewed and the studies were scored according to the Eco-SSL guidance (U.S. EPA, 2003;
Attachment 3-2).  Seventeen studies received an Evaluation Score greater than ten. These
studies are summarized in Table 3.1.

The data in Table 3.1 are sorted by bioavailability score.  There are three study results with a
bioavailability score of two used to derive the plant Eco-SSL for arsenic according to the Eco-
SSL guidance (U.S. EPA, 2003; Attachment 3-2).  The Eco-SSL is the geometric mean of the
maximum acceptable toxicant concentration (MATC) values reported for each of three test
species under two separate test conditions (pH and % organic matter (OM)) and is equal to 18
mg/kg dw.

4.0    ECO-SSL FOR SOIL INVERTEBRATES

Of the papers identified from the literature search process, 35 were acquired for further review.
Of those acquired, one met all 11  Study Acceptance Criteria (U.S. EPA, 2003; Attachment 3-1).
There were no studies that received an Evaluation Score greater than 10.  A soil invertebrate
Eco-SSL could not be derived for arsenic.
Eco-SSL for Arsenic
                                                                             March 2005

-------
    Table 3.1  Plant Toxicity Data - Arsenic
Reference
Jiang and Singh, 1994
Schweizer, 1967
Schweizer, 1967
IP
Number
4441
9659
9659
Study
ID
a
a
b
Test Organism
Ryegrass
Cotton
Rice
Lolium perenne
Gossypium hirsutum stoneville 1A
Oryza saliva L. var. Nato
Soil
PH
5.6
7.9
7.9
OM%
0.7
1.1
1.1
Bio-
availability
Score
2
2
2
ERE
GRO
GRO
GRO
Tox
Parameter
MATC
MATC
MATC
Geometric Mean
Tox Value - Soil
Concentration
(mg/kg dw)
22
69
4
18
Total
Evaluation
Score
13
16
15
Eligible for
Eco-SSL
Derivation?
Y
Y
Y
Used for Eco-
SSL?
Y
Y
Y

Data not Used to Derive Plant Eco-SSL
Jiang and Singh, 1994
Jiang and Singh, 1994
Jiang and Singh, 1994
Woolson and Isensee, 1981
Woolson and Isensee, 1981
Jacobs et al., 1970
Jacobs et al., 1970
Jacobs et al., 1970
Jacobs et al., 1970
Anastasia and Kender, 1973
Jiang and Singh, 1994
Jiang and Singh, 1994
Jiang and Singh, 1994
Jiang and Singh, 1994
4441
4441
4441
56454
56454
5577
5577
5577
5577
11144
4441
4441
4441
4441
e
g
c
a
b
b
c
e
a
a
b
d
f
h
Barley
Barley
Ryegrass
Radish
Soybean
Corn
Snap Bean
Pea
Potato
Blueberry
Ryegrass
Ryegrass
Barley
Barley
Hordeum vulgare
Hordeum vulgare
Lolium perenne
Raphanus sativus
Glycine Max (L.) Merr.
Zea mays
Phaseolus vulgaris
Pisum sativum
Solanum tuberosum
Vaccinium angustifolium
Lolium perenne
Lolium perenne
Hordeum vulgare
Hordeum vulgare
5.6
5.6
5.6
5.1
5.1
5.5
5.5
5.5
5.5
4.6
4.9
4.9
4.9
4.9
0.7
0.7
0.7
1.5
1.5
1.2
1.2
1.2
1.2
0.17-98.0
5.3
5.3
5.3
5.3
2
2
2
1
1
1
1
1
1
0
0
0
0
0
GRO
GRO
GRO
POP
POP
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
LOAEC
LOAEC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
MATC
2
2
22
6
6
40
22
40
97
55
22
22
22
22
13
13
13
13
13
12
12
12
11
13
11
11
11
11
N
N
N
N
N
Y
Y
Y
Y
Y
Y
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
    ERE = Ecologically relevant endpoint
    GRO = Growth
    LOAEC = Lowest observed adverse effect concentration
    MATC = Maximum acceptable toxicant concentration.  Geometric mean of NOAEC and LOAEC.
    N = No
    NOAEC = No observed adverse effect concentration
OM = Organic matter
POP = Population
Y = Yes
Bioavailability Score described in Guidance for Developing Eco-SSLs (U.S. EPA, 2003)
Total Evaluation Score described in Guidance for Developing Eco-SSLs (U.S. EPA, 2003)
Eco-SSL for Arsenic
                                                                      March 2005

-------
5.0    ECO-SSL FOR AVIAN WILDLIFE

The derivation of the Eco-SSL for avian wildlife was completed as two parts. First, the toxicity
reference value (TRV) was derived according to the Eco-SSL guidance (U.S. EPA, 2003;
Attachment 4-5).  Second, the Eco-SSL (soil concentration) was back-calculated for each of
three surrogate species based on the wildlife exposure model and the TRV (U.S. EPA, 2003).

5.1  Avian TRV

The literature search completed according to the Eco-SSL guidance (U.S. EPA, 2003;
Attachment 4-2) identified 1,173 papers with possible toxicity data for either avian or
mammalian species.  Of these papers, 1,110 were rejected for use as described in Section 7.5.
Of the remaining papers, five contained data for avian test species. These papers were reviewed
and data were extracted and scored according to the Eco-SSL guidance (U.S. EPA, 2003;
Attachment 4-3 and 4-4).  The results of the data extraction and review are summarized in Table
5.1. The complete results  are included as Appendix 5-1.

Within the five reviewed papers, there are 16 results for biochemical (BIO), behavioral (BEH),
pathology (PTH), reproduction (REP), growth (GRO), and survival (MOR) effects that meet the
Data Evaluation Score of >65 for use to derive the TRV (U.S. EPA 2003; Attachment 4-5).
These data are plotted in Figure 5.1 and correspond directly with the data presented in Table 5.1.
The no-observed adverse effect (NOAEL) values for growth and reproduction are used to
calculate a geometric mean NOAEL.  This result is examined in relationship to the lowest
bounded lowest-observed  adverse effect level (LOAEL) for reproduction, growth and survival to
derive the TRV according to procedures in the Eco-SSL guidance (U.S. EPA, 2003; Attachment
4-5).

A geometric mean of the NOAEL values for growth and reproduction could not be calculated as
only two values are available.  The TRV is equal to 2.24 mg arsenic/kg bw/day which is the
lowest NOAEL value for reproduction, growth, or survival.

5.2  Estimation of Dose and Calculation of the Eco-SSL

Three separate Eco-SSL values were calculated for avian wildlife, one each  for three surrogate
species representing different trophic groups. The avian Eco-SSLs for arsenic were calculated
according to the Eco-SSL  guidance (U.S. EPA,  2003; Attachment 4-5) and are summarized in
Table 5.2.
Eco-SSL for Arsenic                           5                                 March 2005

-------
                              Table 5.1 Avian Toxicity Data Extracted for Wildlife Toxiciry Reference Value (TRV)
                                                                 Arsenic
                                                                Page 1 of1
Result #
Reference
Ref
No.
Test Organism
# of Cone/ Doses
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
Q
£
Age Units
Lifestage
X
£
Effect Type
Effect Measure
Response Site
NOAEL Dose
(mg/kg bw/day)
LOAEL Dose
(mg/kg bw/day)
Data Evaluation Score
Biochemical (BIO)
1
2
Camardese et al, 1990
Hoffman et al, 1992
5747
1376
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
4
2
UX
UX
FD
FD
10
4
w
w
1
1
d
d
JV
JV
F
B
ENZ
ENZ
ACHE
GLPX
BR
PL


0.410
17.3
76
74
Behavior (BEH)
3
4
5
Camardese et al, 1990
Holcman and Stibilj, 1997
Whitworth et al 1991
5747
5305
5690
Mallard duck (Anas platyrhynchos )
Chicken (Gallus domesticus )
Mallard duck (Anas platyrhynchos )
4
4
4
Patholog
6
7
Camardese et al, 1990
Hoffman et al, 1992
5747
1376
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
4
2
UX
u
u
FD
FD
FD
2
19
9
w
d
w
1
49
1
d
w
d
JV
SM
JV
F
F
NR
FDB
FDB
BEH
FCNS
FCNS
ACTV
WO
WO
wo
1.49
2.24
15.2
4.98

45.7
83
67
78
y(PTH)
UX
UX
FD
FD
10
4
w
w
1
1
d
d
JV
JV
B
B
ORW
ORW
ORWT
ORWT
LI
LI
3.72


17.3
70
77
Reproduction (REP)
8 |Holcman and Stibilj, 1997
5305 | Chicken (Callus domesticus)
4
u |FD
19
d
49
w
LB
F
REP
PROG
WO
2.24

72
Growth (GRO)
9
10
11
12
Holcman and Stibilj, 1997
Camardese et al, 1990
Howell and Hill, 1978
Hoffman et al, 1992
5305
5747
1387
1376
Chicken (Gallus domesticus )
Mallard duck (Anas platyrhynchos )
Chicken (Gallus domesticus )
Mallard duck (Anas platyrhynchos )
4
4
2
2
u
UX
u
UX
FD
FD
FD
FD
19
2
21
4
d
w
d
w
49
1
1
1
w
d
d
d
SM
JV
JV
JV
F
F
B
B
GRO
GRO
GRO
GRO
BDWT
GGRO
BDWT
BDWT
WO
wo
wo
wo
2.24




1.49
3.55
17.3
66
83
76
82
Survival (MOR)
13
14
15
16
Holcman and Stibilj, 1997
Howell and Hill, 1978
Camardese et al, 1990
Hoffman et al, 1992
5305
1387
5747
1376
Chicken (Gallus domesticus )
Chicken (Gallus domesticus )
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
4
2
4
2
u
u
UX
UX
FD
FD
FD
FD
19
21
10
4
d
d
w
w
49
1
1
1
w
d
d
d
SM
JV
JV
JV
F
B
B
B
MOR
MOR
MOR
MOR
MORT
MORT
MORT
SURV
wo
wo
wo
wo
2.24
3.55
3.72
17.3




74
77
84
83
ACHE = acetylcholinesterase; ACTV = general activity levels; B = both; BDWT = body weight changes; BEH = behavior; BR = brain; d = days; ENZ = enzyme changes;
F = female; FCNS = food consumption; FD = food; FDB = feeding behavior; GGRO = general growth changes; GRO = growth; GLPX = gluathione peroxidase; JV =
juvenile; LB = laying bird; LI = liver; LOAEL = lowest observed adverse effect level; MOR = mortality, MORT = mortality; NOAEL = no observed adverse effect level;
NR = Not reported; ORW = organ weight changes; ORWT = organ weight; PL = plasma; PROG = progeny counts; REP = reproduction; SM = sexually mature; SURV =
survival; U = unmeasured; UX = measured but results not reported; w = weeks; WO = whole organism
Eco-SSL for Arsenic
                                                                                                                               March 2005

-------
                                                                 Figure 5.1 Avian TRV Derivation for Arsenic
   •§ 10.000

-------
Table 5.2 Calculation of the Avian Eco-SSLs for Arsenic
Surrogate Receptor
Group
Avian herbivore
(dove)
Avian ground
insectivore
(woodcock)
Avian carnivore
(hawk)
TRY for
Arsenic
(mg dw/kg
bw/d) 1
2.24
2.24
2.24
Food Ingestion
Rate (FIR)2
(kg dw/kg
bw/d)
0.190
0.214
0.0353
Soil Ingestion
as Proportion
of Diet (Ps)2
0.139
0.164
0.057
Arsenic in Biota
Type (i)'2<3
(B,)
(mg/kg dw)
Bi = 0.03752 * Soilj
where i = plants
ln(Bj) = 0.706 *
In(Soilj)- 1.421
where i = earthworms
ln(Bi) = 0.8188*
ln(Soilj) - 4.8471
where i = mammals
Eco-SSL
(mg/kg dw)4
67
43
1100
1 The process for derivation of wildlife TRVs is described in Attachment 4-5 of U.S. EPA (2003).
2 Parameters (FIR, Ps, Bj values, regressions) are provided in U.S. EPA (2003) Attachment 4-1 (revised February 2005).
3 B; = Concentration in biota type (i) which represents 100% of the diet for the respective receptor.
4 HQ = FIR * (Soil, * Ps + Bj) / TRY) solved for HQ=1 where Soil, = Eco-SSL (Equation 4-2; U.S. EPA, 2003).
NA = Not Applicable
6.0    ECO-SSL FOR MAMMALIAN WILDLIFE

The derivation of the Eco-SSL for mammalian wildlife was completed as two parts. First the
TRV was derived according to the Eco-SSL guidance (U.S. EPA, 2003; Attachment 4-5). Second
the Eco-SSL (soil concentration) was back-calculated for each of three surrogate species based
on the wildlife exposure model and the TRV (U.S. EPA, 2003).

6.1  Mammalian TRV

The literature search was completed according to the Eco-SSL guidance (U.S. EPA, 2003;
Attachment 4-2) and identified 1,173 papers with possible toxicity data for arsenic  for either
avian or mammalian test species.  Of these studies, 1,110 were rejected for use as described in
Section 7.5.  Of the remaining papers, 55 contained data for mammalian test species. These
papers  were reviewed and the data were extracted and scored according to the Eco-SSL guidance
(U.S. EPA, 2003; Attachment 4-3 and 4-4).  The results of the data extraction and  review are
summarized in Table 6.1. The complete results are provided in Appendix 6.1.

Within the 55 papers there are 138 results for biochemical (BIO), behavioral (BEH), physiology
(PHY), pathology (PTH), reproduction (REP), growth (GRO), and survival (MOR) endpoints
with a total Data Evaluation Score >65 that were used to derive the TRV (U.S. EPA 2003;
Attachment 4-3). These data are plotted in Figure 6.1 and correspond directly with the data
presented in Table 6.1.  The NOAEL values for growth and reproduction are used to calculate a
geometric mean NOAEL.  This result is examined in relationship to the lowest bounded LOAEL
for reproduction, growth and survival to derive the TRV according to procedures in the Eco-SSL
guidance (U.S. EPA, 2003; Attachment 4-4).
Eco-SSL for Arsenic
March 2005

-------
                  Table 6.1 Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                          Arsenic
                                                        Page 1 of 3
*
Reference
Ref
No.
Test Organism
# of Cone/ Doses
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
a
<
Age Units
Lifestage
**
&
Effect Type
Effect Measure
Response Site
NOAEL Dose
(mg/kg bw/day)
LOAEL Dose
(mg/kg bw/day)
1
Biochemical (BIO)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
Neiger and Osweiler 1989
Neiger and Osweiler, 1992
Wood and Fowler, 1978
Mahaffey et al., 1977
Ghosh et al 1999
Itoh et al., 1990
Schroeder, 1968
Nagaraja and Desiraju, 1994
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Nagaraja and Desiraju, 1994
Glattre et. al.,
Wood and Fowler, 1978
Morrison and Chavez, 1983
Biswas, et al, 2000
Biswas et al, 1998
Garcia- Vargas et al, 1995
Tripathi et al 1997
Garcia- Vargas et al, 1995
14583
15703
15387
14580
15011
14577
15506
15216
14546
14546
15216
11361
15387
15709
25916
15322
15530
14590
15530
Dog (Canis familiaris )
Dog (Canis familiaris )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus)
Pig (Sus scrofa )
Goat (Ovis aries )
Goat (Capra hircus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
4
4
4
2
3
3
2
2
2
2
2
2
4
2
2
2
2
2
2
U
M
U
UX
U
U
U
U
U
U
U
U
U
u
u
u
u
u
u
FD
FD
DR
FD
GV
OR
DR
GV
FD
GV
FD
DR
DR
FD
OR
DR
DR
DR
DR
8
58
6
10
28
14
781
20
90
18
90
4
6
2
3
6
6
16
6
w
d
w
w
d
d
d
d
d
d
d
w
w
w
w
w
w
w
w
8
8
NR
NR
35
4
21-23
2
90
2
90
NR
NR
21
12
1
NR
NR
NR
mo
mo
NR
NR
d
w
d
d
d
d
d
NR
NR
d
mo
yr
NR
NR
NR
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
JV
JV
JV
JV
F
F
M
M
F
M
B
B
NR
B
B
M
M
B
F
F
M
M
M
ENZ
CHM
ENZ
CHM
ENZ
CHM
CHM
ENZ
HRM
HRM
ENZ
HRM
ENZ
ENZ
ENZ
CHM
CHM
HRM
CHM
ASAT
GBCM
GENZ
RBCE
GENZ
TRYP
CHOL
ACHE
DOPA
DOPA
ACHE
TPJI
GENZ
GLPX
ASAT
HMGL
PORP
DOPA
PORP
SR
UR
LI
BL
AR
BR
SR
BR
BR
BR
BR
SR
LI
PL
BL
BL
UR
BR
UR
1.04


















1.66
0.500
1.20
1.50
2.06
2.51
3.78
5.00
5.00
5.00
5.00
6.36
6.60
9.44
14.4
14.4
24.6
32.0
42.1
80
79
69
68
73
77
69
77
68
77
74
69
69
71
70
69
66
66
66
Behavior (BEH)
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
Hunder et al, 1999
Bencko 1972
Neiger and Osweiler 1989
Franke and Moxon 1937
Fowler and Woods 1979
Franke and Moxon 1937
Morrison and Chavez, 1983
Hunder et al, 1999
Benese and Bencko, 1981
Coulson et al, 1935
Mahaffey et al., 1977
Itoh et al., 1990
Brown et al., 1976
Nagaraja and Desiraju, 1994
Nagaraja and Desiraju, 1994
Cabe, et al., 1979
Garcia- Vargas et al, 1995
Garcia- Vargas et al, 1995
15007
15471
14583
14508
15358
14508
15709
15007
15288
14603
14580
14577
4
15216
15216
1244
15530
15530
Guinea pig (Cavia porcellus )
Mouse (Mus musculus )
Dog (Canis familiaris )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Pig (Sus scrofa )
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Mouse (Mus musculus )
4
3
4
2
4
2
2
4
4
2
2
3
4
2
2
2
2
2
u
u
u
u
u
u
u
u
u
M
UX
u
u
u
u
u
u
u
FD
DR
FD
FD
DR
FD
FD
FD
DR
FD
FD
OR
DR
GV
FD
DR
DR
DR
3
64
1
100
6
100
6
3
32
52
10
14
6
21
90
18
6
6
w
d
w
d
w
d
w
w
d
w
w
d
w
d
d
w
w
w
NR
NR
8
28
NR
28
21
NR
NR
33-35
NR
4
NR
2
90
50
NR
NR
NR
NR
mo
d
NR
d
d
NR
NR
d
NR
w
NR
d
d
d
NR
NR
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
F
M
F
M
M
M
B
F
M
B
M
M
M
B
B
M
M
M
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
BEH
FOB
FOB
BEH
FOB
FOB
FOB
FCNS
WCON
FCNS
FCNS
WCON
FCNS
FCNS
FCNS
WCON
FCNS
FCNS
ACTV
WCON
FCNS
ACTP
WCON
WCON
WCON
WO
WO
WO
WO
WO
WO
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
0.844
0.880
1.04
1.88
2.84
3.22
3.59
3.85
6.43









2.53
6.00
1.66

5.69


7.69
32.4
0.472
1.50
2.51
4.70
5.00
5.00
5.81
24.6
42.1
79
73
83
68
74
68
74
79
73
79
71
80
68
80
73
68
69
69
Physiology (PHY)
38
39
40
41
42
43
44
45
46
47
48
Bencko 1972
Kanisawa and Schroeder, 1969
Carmignani et al, 1985
Carmignani et al, 1985
Carmignani et al, 1985
Morrison and Chavez, 1983
Brown et al., 1976
Nagaraja and Desiraju 1993
Carmignani et al 1983
Biswas et al, 1998
Biswas, et al, 2000
15471
15061
15174
15174
15174
15709
4
14546
15249
15322
25916
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rabbit (Oryctolagus cuniculus )
Rat (Rattus norvegicus )
Pig (Sus scrofa )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Goat (Capra hircus )
Goat (Ovis aries )
3
2
2
2
2
2
4
2
2
2
2
u
u
u
u
u
u
u
u
u
u
u
DR
DR
DR
DR
DR
FD
DR
GV
DR
DR
OR
32
18
18
10
18
6
6
18
320
6
9
d
mo
mo
mo
mo
w
w
d
d
w
w
NR
21
NR
NR
NR
21
NR
2
NR
1
12
NR
d
NR
NR
NR
d
NR
d
NR
yr
mo
JV
JV
NR
NR
NR
JV
JV
JV
JV
JV
AD
M
B
M
F
M
B
M
B
M
F
F
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
GPHY
BLPR
GPHY
BLPR
BLPR
EXCR
RPRT
GPHY
GPHY
GPHY
RPRT
LI
wo
wo
wo
wo
wo
KI
HA
HA
BL
WO
0.880










6.00
0.569
2.55
2.61
3.22
3.59
4.70
5.0
5.65
14.4
14.4
73
67
67
67
67
74
68
80
67
72
73
Pathology (PTH)
49
50
51
52
53
54
55
56
57
58
Hughes and Thompson, 1996
Coulson et al, 1935
Kanisawa and Schroeder, 1969
Nemec et al, 1998
Bencko 1972
Obermeyer et al, 1971
Tice et al 1997
Neiger and Osweiler 1989
Fowler et al., 1977
Fowler and Woods 1979
15160
14603
15061
15057
15471
12934
14589
14583
14569
15358
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rabbit (Oryctolagus cuniculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Dog (Canis familiaris )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
3
2
2
4
3
2
4
4
4
4
u
M
u
M
u
u
u
u
u
u
DR
FD
DR
GV
DR
FD
GV
FD
DR
DR
28
52
42
7
64
4
4
8
6
6
d
w
mo
d
d
w
d
w
w
w
96
33-35
21
NR
NR
NR
12
8
NR
NR
d
d
d
NR
NR
NR
w
mo
NR
NR
SM
JV
JV
GE
JV
JV
JV
JV
JV
JV
F
B
B
F
M
M
M
F
M
M
ORW
HIS
HIS
GRS
ORW
ORW
HIS
ORW
HIS
HIS
ORWT
GfflS
GfflS
BDWT
ORWT
SMIX
USTR
SMIX
USTR
USTR
LI
LI
KI
WO
SP
LI
BL
LI
LI
LI
0.000859
0.447
0.569
0.750
0.880
0.913
1.44
1.66
2.22
2.84
0.0859


3.0
6.00

2.88

4.43
5.69
67
69
67
84
73
73
86
68
74
74
Eco-SSL for Arsenic
                                                                                                                 March 2005

-------
                  Table 6.1 Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                          Arsenic
                                                        Page 2 of 3
*
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
Reference
Byron et al, 1967
Byron et al, 1967
Nemec et al, 1998
Garcia- Vargas et al, 1995
Garcia- Vargas et al, 1995
Seidenberg et al 1986
Healy et al., 1998
Healy et al., 1998
Schroeder et al, 1968
Mahaffey et al., 1977
Ghosh et al 1999
Brown et al., 1976
Nagaraja and Desiraju, 1994
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Nagaraja and Desiraju, 1994
Carmignani et al 1983
Ref
No.
2
2
15057
15530
15530
113
14543
14543
7
14580
15011
4
15216
14546
14546
15216
15249
Test Organism
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Mouse {Mus musculus )
Mouse (Mus musculus )
Mouse {Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
# of Cone/ Doses
6
6
4
2
2
2
3
3
2
2
3
4
2
2
2
2
2
Method of Analyses
U
U
M
U
U
U
U
U
U
UX
U
U
U
u
u
u
u
Route of Exposure
FD
FD
GV
DR
DR
GV
DR
DR
DR
FD
GV
DR
GV
FD
GV
FD
DR
Exposure Duration
2
2
6
6
6
5
91
32
1575
10
28
6
20
90
18
90
320
Duration Units
yr
yr
d
w
w
d
d
d
d
w
d
w
d
d
d
d
d
a
<
NR
NR
NR
NR
NR
NR
76
76
21-23
NR
35
NR
2
90
2
90
NR
Age Units
NR
NR
NR
NR
NR
NR
d
d
d
NR
d
NR
d
d
d
d
NR
Lifestage
JV
JV
GE
JV
JV
GE
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
**
&
B
B
F
M
M
F
M
M
M
M
F
M
B
NR
B
B
M
Effect Type
HIS
HIS
GRS
ORW
ORW
GRS
ORW
PTH
ORW
GRS
ORW
ORW
ORW
ORW
ORW
ORW
HIS
Effect Measure
GfflS
GfflS
BDWT
SMIX
SMIX
BDWT
ORWT
ORWT
SMIX
BDWT
SMIX
SMIX
ORWT
ORWT
ORWT
ORWT
GfflS
Response Site
LI
LI
WO
LI
LI
WO
LI
KI
HE
WO
AR
KI
BR
BR
BR
BR
KI
NOAEL Dose
(mg/kg bw/day)
4.91
9.84
24.0
24.6
42.1
43.4











LOAEL Dose
(mg/kg bw/day)
9.81
19.7
48.0



0.00650
0.00850
0.533
1.50
2.06
4.70
5.00
5.0
5.0
5.00
5.65
1
79
79
86
69
69
78
68
68
68
71
76
68
80
71
80
73
67
Reproduction (REP)
76
77
78
79
80
81
82
83
Savabieasfahani et al, 1998
Nemec et al, 1998
Morris et al, 1938
Nemec et al, 1998
Healy et al., 1998
Schroeder and Mitchener, 1971
Skalnaya et al, 1996
Seidenberg et al 1986
14556
15057
15125
15057
14543
66
15167
113
Cotton rat (Sigmodon hispidus )
Rabbit (Oryctolagus cuniculus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
3
4
3
4
3
2
2
2
u
M
U
M
U
U
U
U
DR
GV
FD
GV
DR
DR
OR
GV
6
12
340
9
91
6
30
5
w
d
d
d
d
mo
d
d
NR
NR
26-27
NR
76
21
NR
NR
NR
NR
d
NR
d
d
NR
NR
AD
GE
JV
GE
JV
JV
GE
GE
M
F
M
F
M
F
F
F
REP
REP
REP
REP
REP
REP
REP
REP
TEWT
RSEM
PRWT
PROG
TEWT
PROG
PRWT
PROG
TE
WO
WO
WO
TE
WO
WO
WO
0.601
0.750
7.47
24.0





3.0

48.0
0.00650
0.548
5.66
43.4
70
90
71
92
74
67
81
86
Growth (GRO)
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
Hughes and Thompson, 1996
Coulson et al, 1935
Kanisawa and Schroeder, 1969
Schroeder et al, 1968
Obermeyer et al, 1971
Neiger and Osweiler 1989
Palmer et al 1983
Palmer et al 1983
Franke and Moxon 1937
Byron et al, 1967
Schmolke et al 1992
Fowler and Woods 1979
Franke and Moxon 1937
Ghosh et al 1999
Fowler et al., 1977
Hunder et al, 1999
Bencko 1972
Benese and Bencko, 1981
Morris et al, 1938
Hunder et al, 1999
Brown et al., 1976
Byron et al, 1967
Byron et al, 1967
Kanisawa and Schroeder, 1967
Schroeder and Balassa, 1967
Hunder et al, 1999
Nagaraja and Desiraju, 1994
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Kiyono et al, 1974
Nagaraja and Desiraju, 1994
Glattre et. al.,
Morrison and Chavez, 1983
Biswas et al, 1998
Biswas, et al, 2000
15160
14603
3701
7
12934
14583
15262
15262
14508
2
15264
15358
14508
15011
14569
15007
15471
15288
15125
15007
4
2
2
20979
3084
15007
15216
14546
14546
15427
15216
11361
15709
15322
25916
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Dog (Canis familiaris )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Dog (Canis familiaris )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Guinea pig (Cavia porcellus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Pig (Sus scrofa )
Goat (Capra hircus )
Goat (Ovis aries )
3
2
2
2
2
4
2
2
2
5
3
4
2
3
4
4
3
4
3
4
4
6
6
2
2
4
2
2
2
4
2
2
2
2
2
U
M
U
U
U
U
U
U
U
U
U
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
u
DR
FD
DR
DR
FD
FD
FD
FD
FD
FD
FD
DR
FD
GV
DR
FD
DR
DR
FD
FD
DR
FD
FD
DR
DR
FD
GV
FD
GV
GV
FD
DR
FD
DR
OR
28
52
519
69
4
8
4
8
100
2
15
6
100
28
6
3
64
32
340
3
6
12
12
338
339
3
20
90
18
10
90
4
2
9
9
d
w
d
d
w
w
w
w
d
yr
w
w
d
d
w
w
d
d
d
w
w
w
w
d
d
w
d
d
d
d
d
w
w
w
w
96
33-35
21
21-23
NR
8
NR
NR
28
6
7
NR
28
35
NR
NR
NR
NR
26-27
NR
NR
NR
NR
20-22
21
NR
2
90
2
1
90
NR
21
1
12
d
d
d
d
NR
mo
NR
NR
d
mo
w
NR
d
d
NR
NR
NR
NR
d
NR
NR
NR
NR
d
d
NR
d
d
d
d
d
NR
d
yr
mo
SM
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
F
B
B
B
NR
F
M
M
M
B
F
M
M
F
M
F
M
M
M
F
M
B
M
M
B
F
B
NR
B
M
B
M
B
F
F
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
WO
WO
WO
WO
WO
WO
WO
WO
WO
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
0.0859
0.447
0.533
0.571
0.913
1.04
1.39
1.65
1.88
2.25
2.52
2.84
3.22
3.78
4.43
5.52
6.00
6.43
7.47
7.69
9.40
9.84
10.3

















1.66



5.62

5.69


9.42


32.4


10.7
19.7
20.6
0.663
0.665
0.844
5.00
5.0
5.0
5.0
5.00
6.36
9.44
14.4
14.4
69
74
72
72
77
87
68
68
72
82
68
78
72
73
78
68
73
77
69
68
78
83
83
72
72
77
84
75
84
84
77
76
78
76
77
Eco-SSL for Arsenic
                                                                                                                 March 2005

-------
                  Table 6.1 Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                          Arsenic
                                                        Page 3 of 3
*
Reference
Ref
No.
Test Organism
# of Cone/ Doses
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
§i
<
Age Units
Lifestage
W
$
Effect Type
Effect Measure
Response Site
NOAEL Dose
(mg/kg bw/day)
LOAEL Dose
(mg/kg bw/day)
1
Survival (MOR)
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
Schroeder et al, 1968
Nemec et al, 1998
Palmer et al 1983
Palmer et al 1983
Franke and Moxon 1937
Byron et al, 1967
Byron et al, 1967
Nemec et al, 1998
Franke and Moxon 1937
Kiyono et al, 1974
Cabe, et al., 1979
Fowler et al., 1977
Byron et al, 1967
Byron et al, 1967
Nemec et al, 1998
Tripathi et al 1997
Schroeder and Balassa, 1967
Biswas et al, 1998
Biswas, et al, 2000
Seidenberg et al 1986
7
15057
15262
15262
14508
2
2
15057
14508
15427
1244
14569
2
2
15057
14590
3084
15322
25916
113
Rat (Rattus norvegicus )
Rabbit (Oryctolagus cuniculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Dog (Canis familiaris )
Dog (Canis familiaris )
Rabbit (Oryctolagus cuniculus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Rat (Rattus norvegicus )
Mouse (Mus musculus )
Goat (Capra hircus )
Goat (Ovis aries )
Mouse (Mus musculus )
2
4
2
2
2
5
5
6
2
4
2
4
6
6
4
2
2
2
2
2
U
M
U
U
U
U
U
M
U
U
U
U
U
U
M
U
U
U
U
U
DR
GV
FD
FD
FD
FD
FD
GV
FD
GV
DR
DR
FD
FD
GV
DR
DR
DR
OR
GV
1575
12
4
8
100
2
13.5
12
100
21
18
6
78
2
9
16
519
78
12
5
d
d
w
w
d
yr
mo
d
d
d
w
w
w
yr
d
w
d
d
w
d
21-23
NR
NR
NR
28
6
6
NR
28
1
50
NR
NR
NR
NR
NR
21
1
12
NR
d
NR
NR
NR
d
mo
mo
NR
d
d
d
NR
NR
NR
NR
NR
d
yr
mo
NR
JV
GE
JV
JV
JV
JV
JV
GE
JV
JV
JV
JV
JV
JV
GE
JV
JV
JV
AD
GE
B
F
M
M
M
B
B
F
M
M
M
M
B
B
F
M
M
F
F
F
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
SURV
MORT
MORT
SURV
MORT
MORT
MORT
MORT
MORT
MORT
MORT
MORT
SURV
SURV
MORT
MORT
SURV
MORT
MORT
MORT
WO
WO
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
0.533
0.750
1.39
1.65
1.88
2.25
2.25
2.25
3.22
5.0
5.81
9.63
9.65
9.99
24.0
32.0





3.00



5.62
5.62
4.50

7.5


19.3
20.0
48.0

0.675
14.4
14.4
43.4
73
89
78
69
82
83
83
91
73
91
73
73
84
84
91
74
73
77
78
85
ACHE = acetylcholinesterase; ACTP = accuracy of learned behavior; ACTV = activity, general; AD = adult; AR = adrenal; ASAT = aspartate aminotransferase; B = both;
BDWT = body weight changes; BEH = behavior; BL = blood; BLPR = blood pressure; BR = brain; bw = body weight; CHM = chemical changes; CHOL = cholesterol; d -
day; DOPA = dopamine; DR = Drinking water; ENZ = enyzme level changes; EXCR = excretion; F = female; FCNS = food consumption; FD = food; FDB = feeding
behavior; GBCM = general biochemical changes; GE = gestation; GENZ = general enzyme changes; GFflS = general histology; GLPX = glutathione peroxidase; GPF1Y =
general pysiology changes; GRO = growth; GRS = gross body weight changes; GV = gavage; FLA = hair; HE = heart; HIS = histological changes;HMGL = hemoglobin; HRM
= hormone changes; JV = juvenile; kg = kilograms; KI = kidney; L = liter; LI = liver; LOAEL = lowest observed adverse effect level; mo = months; M = male; M = measured;
MOR = effects on mortality and survival; MORT = mortality; NOAEL = No Observed Advese Effect Level; NR = Not reported; OR = other oral;
ORW = organ weight changes; ORWT = organ weight changes; PHY = physiology; PL = plasma; PORP = porphyrin; PROG = progeny numbers/counts; PRWT = progeny
weight; PTH = pathology; RBCE = red blood cell count; REP = reproduction; RPRT = respiratory rate; RSEM = resorbed embryo; SM = sexually mature; SMTX = weight
relative to body weight; SP = spleen; SR = serum; SURV = survival; TE = testes; TEWT = testes weight; TRII = tridothyronine; TRYP = tryptophan; U = unmeasured; UR =
urine; USTR = ultrastructural changes; UX = measured but values not reported; w = weeks; WCON = water consumption; WO = whole organism; yr = year.
Eco-SSL for Arsenic
                                                                                                                 March 2005

-------
                                                             Figure 6.1 Mammalian TRV Derivation for Arsenic
                                                                                                                                       TRY = Highest bounded NOAEL lowei
                                                                                                                                          than lowest bounded LO AEL for
                                                                                                                                        reproduction, growth or survival =1.04
0.000
            Biochemical (BIO)
                                  Behavior (BEH)
                                                       Physiology (PHY)
                                                                               Pathology (PTH)
                                                                                                        Reproduction (REP)
                                                                                                                                    Growth (GRO)
                                                                                                                                                                          Mortality (MOR)
  • BIO-NOAEL OBIO-LOAEL •BEH-NOAEL OBEH-LOAEL  OPHY-NOAEL  OPHY-LOAEL  OPTH-NOAEL   PTH-LOAEL  »REP-NOAEL OREP-LOAEL  OGRO-NOAEL    GRO-LOAEL  OMOR-NOAEL   MOR-LOAEL
Wildlife TRV Derivation Process
                                                                                          Lowest-Observed Adverse Effect Dose

                                                                                          Paired values from same study whenjoined by line

                                                                                          No-Observed Adverse Effect Dose
                                                            Data Evaluation Score
 1)  There are at least three results available for two test species within the growth, reproduction, and mortality effect groups.
    There are enough data to derive a TRV.

 2)  There are three NOAEL results available within the growth and reproduction effect groups for calculation of a geometric mean.

 3)  The geometric mean is equal to 2.47 mg arsenic /kg bw/d and is lower than the lowest bounded LOAEL for results within the reproduction, growth, and survival (MOR) effect groups.
 4)  The mammalian wildlife TRV for arsenic is equal to 1.04 mg arsenic/kg bw/day which is the geometric mean of NOAEL values for reproduction and growth.
Eco-SSL for Arsenic
                                                                                                12
                                                                                                                                                                                      March 2005

-------
A geometric mean of the NOAEL values for growth and reproduction was calculated at 2.47 mg
arsenic/kg bw/day.  However, this value is higher than the lowest bounded LOAEL for
reproduction, growth, or survival results. Therefore, the TRV is equal to 1.04 mg arsenic/kg
bw/day which is the highest bounded NOAEL lower than the lowest bounded LOAEL for
reproduction, growth or survival.

6.2   Estimation of Dose and Calculation of the Eco-SSL

Three separate Eco-SSL values were calculated for mammalian wildlife, one each for three
surrogate species representing different trophic groups. The mammalian Eco-SSLs for arsenic are
calculated according to the Eco-SSL guidance (U.S. EPA, 2003; Attachment 4-5) and are
summarized in Table 6.2
Table 6.2 Calculation of the Mammalian Eco-SSLs for Arsenic
Surrogate Receptor
Group
Mammalian herbivore
(vole)
Mammalian ground
insectivore (shrew)
Mammalian carnivore
(weasel)
TRV for
Arsenic
(mg dw/kg
bw/d) 1
1.04
1.04
1.04
Food Ingestion
Rate (FIR)2
(kg dw/kg bw/d)
0.0875
0.209
0.130
Soil Ingestion
as Proportion
of Diet (PJ2
0.032
0.030
0.043
Arsenic in Biota
Type (i)2'3
(B,)
(mg/kg dw)
Bj = 0.03752 * Soilj
where i = plants
ln(Bj) = 0.706 *
ln(Soilj)- 1.421
where i = earthworms
ln(Bi) = 0.8188*
hXSoilj) - 4.8471
where i = mammals
Eco-SSL
(mg/kg dw)4
170
46
170
1 The process for derivation of wildlife TRVs is described in Attachment 4-5 of U.S. EPA (2003).
2 Parameters (FIR, Ps, Bj values, regressions) are provided in U.S. EPA (2003) Attachment 4-1 (revised February 2005).
3 Bj = Concentration in biota type (i) which represents 100% of the diet for the respective receptor.
4 HQ = FIR * (Soilj * Ps + Bt) / TRV) solved for HQ=1 where Soilj = Eco-SSL (Equation 4-2; U.S. EPA, 2003).
NA = Not Applicable
Eco-SSL for Arsenic
13
March 2005

-------
This Page Intentionally Left Blank

-------
7.0    REFERENCES

7.1    General Arsenic References

American Petroleum Institute (API).  1998. Arsenic: Chemistry, Fate, Toxicity, and Wastewater Treatment Options.
Health and Environmental Sciences Department. Publication 4676.

Canadian Council of Ministers of the Environment (CCME).  1996. Recommended Canadian Soil Quality
Guidelines for Arsenic: Environmental and Human Health, Supporting Document - Final Draft.  December 1996.

Cullen, W.R. and K. J. Reimer. 1989. Arsenic speciation in the environment. Chem. Rev.  89: 713-764.

Huang, Y-C.  1994. Arsenic distribution in soils. In: Arsenic in the Environment. Part I: Cycling and
Characterization, pp 17-49. J. O. Nriagu (ed.), John Wiley & Sons, Inc., New York.

United States Environmental Protection Agency (U.S. EPA).  2003. Guidance for Developing Ecological Soil
Screening Levels (Eco-SSLs).   November. Office of Emergency and Remedial Response,  Washington, DC.
OSWER Directive 9285.7-55.

United States Environmental Protection Agency (U.S. EPA).  1999. Ecological Risk Assessment and Risk
Management Principles for Super fund Sites.  Office of Emergency and Remedial Response, Washington, DC.
OSWER Directive 9285.7-28.P.

United States Environmental Protection Agency (U.S. EPA).  1998. Guidelines for Ecological Risk Assessment.
Risk Assessment Forum. U.S. Environmental Protection Agency, Washington DC. EPA/630/R-95/002F.  April.
May 14, 1998 Federal Register 63(93): 26846-26924.

United States Environmental Protection Agency (U.S. EPA).  1997. Ecological Risk Assessment Guidance for
Superfund:  Process for Designing and Conducting Ecological Risk Assessments.  Interim Final.  U.S.
Environmental Protection Agency, Environmental Response Team (Edison, NJ). June 5, 1997.
7.2    References Used for Derivation of Plant and Soil Invertebrate Eco-SSLs

Anastasia, F. B. andKender, W. J.  1973. The Influence of Soil Arsenic on the Growth of Lowbush Blueberry.
J.Environ.Qual. 2(3):  335-337

Jacobs, L. W., Keeney, D. R.,  and Walsh, L. M. 1970. Arsenic Residue Toxicity to Vegetable Crops Grown on
Plainfield Sand. Agron. J. 62: 588-591.

Jiang, Q. Q. and Singh, B. R. 1994. Effect of different forms and sources of arsenic on crop yield and arsenic
concentration. Water Air Soil Pollut. 74(3/4): 321-343.

Schweizer, E. E.  1967. Toxicity of DSMA Soil Residues to Cotton and Rotational Crops.  Weed Sci. 15(1): 72-76.

Woolson, E. A. and Isensee, A. R.  1981.  Soil Residue Accumulation from Three Applied Arsenic Sources. Weed
Sci. 29(1): 17-21.
Eco-SSL for Arsenic                               14                                      March 2005

-------
7.3    References Rejected for Use in Derivation of Plant and Soil Invertebrate Eco-SSLs

These references were reviewed and rejected for use in derivation of the Eco-SSL.  The
definition of the codes describing the basis for rejection is provided at the end of the reference
sections.

No Tox         Albert, W. B. and Arndt, C. H. 1931. The Concentration of Soluble Arsenic as an Index of
                Arsenic Toxicity to Plants.  South Carolina Agric Exp StaAnn Rep  44: 47-48 (1931)

OM, pH        Amonoo-Neizer, E. H., Nyamah, D., and Bakiamoh, S. B. 1996. Mercury and Arsenic Pollution
                in Soil and Biological Samples Around the Mining Town of Obuasi, Ghana.  Water Air Soil Pollut.
                91(3/4): 363-373 (1996)

No Cone        Amonoo-Neizer, Eugene H. and Amekor, Emmanuel M. K.  1983. Determination of Total Arsenic
                in Environmental Samples fromKumasi and Obusai, Ghana. Environ. Health  Perspect. 101(1):
                46-49 (1993)

pH,             Anderson, L. W. I, Pringle, J. C, and Raines, R. W. 1978.  Arsenic Levels in Crops Irrigated
                with Water Containing MSMA. WeedSci. 26(4): 370-373.

No Cone        Arnott, J. T. and Leaf, A. L.  1967.  The Determination and Distribution of Toxic Levels of
                Arsenic in a Silt Loam Soil.  WeedSci.  15(2):  121-124.

Media          Asher, C. J. and Reay, P. F.  1979.  Arsenic Uptake by Barley Seedlings. Aust. J. Plant Physiol.
                6: 459-466 (1979).

No Cone        Baker, R. S., Barrentine, W. L., Bowman, D. H., Hawthorne, W. L., and Pettier, J. V. 1976. Crop
                Response and Arsenic Uptake Following Soil Incorporation of MSMA. WeedSci. 24(3): 322-326.

Mix            Bardgett, R. D., Speir, T. W., Ross, D. J., Yeates, G. W., and Kettles, H. A.  1994. Impact of
                Pasture Contamination by Copper, Chromium, and Arsenic Timber Preservative on Soil Microbial
                Properties and Nematodes. Biol.Fertil.Soils 18(1): 71-79.

Media          Barrachina, A. C., Carbonell, F. B., and Beneyto, J. M. 1995. Arsenic Uptake, Distribution and
                Accumulation in Tomato Plants: Human Health Risk. Fresenius Environ.Bull. 4: 395-400 (1995)

Mix            Batjer, L. P. and Benson, N. R. 1958. Effect of Mtal Chelates in Overcoming Arsenic Toxicity to
                Peach Trees. Proc Am Soc Hort Sci 72: 74-78 (1958)

No Dur         Bech, Jaume, Poschenrieder, Charlotte, Llugany, Merce, Barcelo, Juan, Tume, P., Tobias, F. J.,
                Barranzuela, J. L., and Vasquez, E. R.  1997. Arsenic and heavy metal contamination of soil and
                vegetation around a copper mine in northern peru.  Science of the Total Environment.  203(1):
                83-91.

No Control      Benson, L. M., Porter, E. K., and Peterson, P. J. 1981. Arsenic Accumulation, Tolerance  and
                Genotypic Variation in Plants on Arsenical Mine Wastes in S.W.England. J.  Plant Nutr.  3(1-4):
                655-666 (1981)

OM            Benson, N. R.  1953. Effect of Season, Phosphate and Acidity in Plant Growth in Arsenic-Toxic
                Soils. Soil Sci. 76: 215-224 (1953)

OM            Benson, N. R.  1976. Retardation of Apple Tree Growth by Soil Arsenic Residues. J. Am. Soc.
                Hortic. Sci.  101(3): 251-253 (1976)
Eco-SSL for Arsenic
15
March 2005

-------
Media          Bhattacharya, A. and Mandal, S. 1999. Loss of Pollen Viability of Cassia siamea Lamk,
                Following Treatment with Arsenic. J. Environ. Biol.  20(1): 67-69.

Rev            Bibhas, R.  1975.  Fate of Organic Arsenicals in Soils and Plants.  Int. Pest. Control.  17:  9-14.

Score           Biro, B., Koves-Pechy, K., Voros, I., and Kadar, I. 1998. Toxicity of Some Field Applied Heavy
                Metal Salts to the Rhizobial and Fungal Microsymbionts of Alfalfa and Red Clover. Agrokem.
                Talajtan.  47(1-4): 265-276.

OM            Bishop, R. F. and Chisholm, D. 1962.  Arsenic Accumulation in Annapolis Valley Orchard Soils.
                Can. J. Soil Sci. 42: 77-80.

ERE           Blatt,  C. R.  - Effect of Arsenic and Molybdenum on Plant Response of Cauliflower (Brassica
                oleracea) Grown in Sand Culture. In: M.L.VanBuesichem, (Ed.),  Plant Nutr. Physiol. Appl.  41:
                303-306 (1990)

Species         Bliss,  C. I.   1936. The Size Factor in the Action of Arsenic upon Silkworm Larvae. Exp.  Biol.
                13: 95-110.

Mix            Boisson, J., Ruttens, A., and Vangronsveld, J.  1999.  Evaluation of Hydroxyapatite as a Metal
                Immobilizing Soil Additive for the Remediation of Polluted Soils. Part I. Influence of
                Hydroxyapatite on Metal Exchangeability in Soil, Plant Growth and Plant Metal Accumulation.
                Environ. Pollut. 104(2):  225-233.

Rev            Braman, R. S.  1975. Arsenic in the Environment. In: E.A.Woolson (Ed.), Arsenical Pesticides,
                Chapter 8, ACS Symp.Ser.No.7, Washington, D.C. 108-123.

Media          Brenchley, W. E.  1914.  On the Action of Certain Compounds of Zinc, Arsenic, and Boron on the
                Growth of Plants.  Ann. Bot.  28:283-301.

OM, pH        Burlo, F., Guijarro, I., Carbonell-Barrachina, A. A., Valero,  D., and Martinez-Sanchez, F.  1999.
                Arsenic Species: Effects on and Accumulation by Tomato Plants.  J. Agric. Food Chem.  47(3):
                1247-1253.

Species         Campbell, F. L.  1926. Relative Susceptibility to Arsenic in Successive Instars of the Silkworm.
                Gen Physiol.  9(6): 727-733.

OM, pH        Carbonell-Barrachina, A. A., Burlo-Carbonell, F., and Mataix-Beneyto, J.  1997.  Arsenic Uptake,
                Distribution and Accumulation in Bean Plants: Effect of Arsenite and Salinity on Plant Growth
                and Yield.  J. Plant  Nutr. 20(10): 1419-1430.

Media          Carbonell-Barrachina, A. A., Aarabi, M. A., DeLaune, R. D., Gambrell, R. P., and Patrick, W. H.,
                Jr.  1998. The influence of arsenic chemical form and concentration on Spartina patens and
                Spartina alterniflora growth and tissue arsenic concentration. Plant Soil. 198(1): 33-43.

OM, pH        Carbonell-Barrachina, A. A., Burlo, F., and Mataix, J. 1998.  Response of Bean Micronutrient
                Nutrition to Arsenic and Salinity. J. Plant Nutr.  21(6):  1287-1299.

OM            Carbonell-Barrachina, A. A., Burlo, F., Lopez, E., and Martinez-Sanchez, F. 1999.  Arsenic
                Toxicity and Accumulation in Radish as Affected by Arsenic Chemical Speciation. J. Environ.
                Sci. Health. Part B.  34(4): 661-679.
Eco-SSLfor Arsenic
16
March 2005

-------
Media          Carbonell-Barrachina, A. A., Burlo, F., Valero, D., Lopez, E., Martinez-Romero, D., and
                Martinez-Sanchez, F.  1999.  Arsenic Toxicity and Accumulation in Turnip as Affected by Arsenic
                Chemical Speciation. J. Agric. Food Chem. 47(6): 2288-2294.

Media          Carbonell Abrrachina, A., Burlo Carbonell, F., and Mataix Beneyto, J.  1995. Arsenic uptake,
                distribution, and accumulation in tomato plants: effect of arsenite on plant growth and yield.
                J.PlantNutr. 18(6):  1237-1250.

Media          Carbonell, A. A., Aarabi, M. A., DeLaune, R. D., Gambrell, R. P., and Patrick, W. H.  1998.
                Arsenic in wetland vegetation: Availability, phytotoxicity, uptake and effects on plant growth and
                nutrition. Science of the Total Environment. 217(3):  189-199.

OM, pH        Carbonell, A. A., Aarabi, M. A., DeLaune, R. D., Gambrell, R. P., and Patrick, W. H., Jr.  1998.
                Bioavailability and uptake of arsenic by wetland vegetation: effects on plant growth and nutrition.
                J.Environ.Sci.Health Part A  A33(l): 45-66.

Species         Carriker, N. E., Gillespie, W. T., and Brezonik, P. L.  1976.  Boron and Arsenic Studies in Florida
                Waters. Florida Water Resources Council, Publ.No.34, Gainesville, FL (Cited in Demayo et al
                1979): 3-48.

Score           Carrow, R. N., Rieke, P. E., and Ellis, B. G. 1975.  Growth of Turf grasses as Affected by Soil
                Phosphorus and Arsenic.  Soil Sci Am Proc. 39:1121-1124.

ERE            Cataldo, D. A. and Wildung, R. E.   1978.  Soil and Plant Factors Influencing the Accumulation of
                Heavy Metals by Plants. Environ. Health Perspect. 27:  149-159.

Abstract        Chaney, R. and Ryan, J. 1995. Risk Based Standards For Arsenic, Lead And Cadmium In Urban
                Soils. Summary Of Information And Methods Developed To Estimate Standards For Cd, Pb And
                As In Urban Soils. Govt-Reports-Announcements-&-Index-(GRA&I) (19).

Media          Chen, Shyi Hwan.  1997. An investigation on the effect of arsenic poisoning on humans,
                agriculture, and fisheries. J.  Chin. Chem. Soc. (Taipei). 44(2): 115-121.

FL             Chen, T. and Liu, G. 1993.  Effects of Soil pH on Arsenic Adsorption in Soil  and Its Toxicity to
                Rice (Oryza sativa L.).  Zhongguo Nongye Kexue (Beijing)  26(1): 63-68 (CHI).

OM            Chen, T. and and Liu, G.  1993. Effect of Arsenic on Rice (Oryza sativa L.) Growth and
                Development and Its Mechanism. Scientia Agricultura Sinica (Zhongguo Nongye Kexue (Beijing))
                26(6): 50-58.

OM, pH        Chisholm, D.  1972. Lead, Arsenic, and Copper Content of Crops Grown on Lead Arsenate-
                Treated and Untreated Soils. Can. J. Plant Sci. 52: 583-588.

OM, pH        Clements, H. F. and Munson, J.  1947.  Arsenic Toxicity Studies in Soil and in Culture Solutions.
                PacSci.  1:151-171.

Mix            Codling, E. E. and Wright, R. J. 1998. Plant Uptake  of Selenium Arsenic and Molybdenum From
                Soil Treated with Coal Combustion Byproducts. Fresenius Environ. Bull. 7(1-2):  118-125.

No Data        Cooper, H. P., Paden, W. R., Hall, E. E., Albert, W. B., Rogers, W. B., and Riley, J. A. 1931.
                Effect of Calcium Arsenate on the Productivity of Certain Soil Types. S.C. Agric. Exp. Stn. Ann.
                Rep. No. 44 , 28-36.
Eco-SSLfor Arsenic
17
March 2005

-------
Score
Covey, R. P., Koch, B. L., and Larsen, H. J.  1981.  Influence of Vesicular Arbuscular
Mycorrhizae on the Growth of Apple and Corn in Low-Phosphorous Soil.  Phytopathology. 11:
712-715.
Score           Cox, M. S., Bell, P. F., and Kovar, J. L.  1996.  Differential Tolerance of Canola to Arsenic when
                Grown Hydroponically or in Soil. J. Plant Nutr. 19(12):  1599-1610.

OM, pH        Crafts, A. S. and Rosenfels, R. S.  1939.  Toxicity Studies with Arsenic in Eighty California Soils.
                Hilgardia. 12(3):  177-200.

No Data        Crafts, A. S. 1935. The Toxicity of Sodium Arsenite and Sodium Chlorate in Four California Soils.
                Hilgardia. 9: 462-498.

Species         Crecelius, E. A., Johnson, C. J., and Hofer, G. C. 1974. Contamination of Soils Near a Copper
                Smelter by Arsenic, Antimony, and Lead.  Water Air  Soil PoHut.  3:337-342.

Mix            Da Costa, E. W. B. and Bezemer, L. D.  1973.  Anti-Fungal Effectiveness of
                Copper-Chrome-Arsenic Preservatives in a Phosphatic Environment. Int. Biodeterior. Bull. 9(1/2):
                44-48.

OM, pH        Daris, B. T., Papadopoulou, C, Kleperis, I, and Grimanis, A. P. 1970.  Herbicide Influence on
                the Arsenic Uptake of Grapes. A Study by Neutron Activation Analysis. Proc. Br. Weed Control
                Conf. 10(1): 429-433.

Mix            Davis, R. D., Beckett, P. H. T., and Wollan, E.  1978.  Critical Levels of Twenty Potentially Toxic
                Elements in Young Spring Barley. Plant Soil.  49:395-408.

Mix            De Koe, T.  1991.  Arsenic in Water, Sediment and Vegetation of the Jales Go Id Mine, North
                Portugal. In: J.Rozema and J.A.C.Verkleij (Eds.), Ecological Responses to Environmental
                Stresses, Chapter 5, Kluwer Acad.Publ., Netherlands : 42-47 (1991)

No Data        Dorman, C., Tucker, F. H., and Coleman, R.  1939. The Effect of Calcium Arsenate upon the
                Productivity of Several Important Soils of the Cotton Belt.  JAmSocAgron.  31:  1020-1028.

No Cone        Deuel, L. E. and Swoboda, A.  R.  1972.  Arsenic Toxicity to  Cotton and Soybeans.  J. Environ.
                Qual. 1(3): 317-320.

Rev            Environment Canada. - Canadian Soil Quality  Guidelines for Arsenic: (Environmental and Human
                Health). Draft Document.Guidelines Division, Evaluation and Interpretation Branch,
                Environmental Conservation Service, Environment Canada, Ottawa : 61 p. (1996)

ERE            Escritt, J. R.  1955.  Calcium Arsenate for Earthworm Control. J Sports Turf Res Inst 9: 28-34 .

Media          Fargasova, A.  1994. Effect of Pb, Cd, Hg, As, and Cr on Germination and Root Growth of
                Sinapis alba Seeds. Bull.  Environ. Contam. Toxicol. 52: 452-456 .

OM, pH        Fergus, I. F. 1955.  A Note on Arsenic Toxicity in Some Queensland Soils. Queensland J. Agric.
                Sci.  12(4): 95-100 (1955)

No Cone        Fodor, L. 1998.  Effect of Heavy Metals on Wheat and Maize Crop on Brown Forest Soil.
                Agrokem.Talajtan. 47(1-4): 197-206.

Rev            Fowler, B. A. and Mahaffey, K. R.  1978.  Interactions Among Lead, Cadmium, and Arsenic in
                Relation to Porphyrin Excration Patterns. Environ.Health Perspect. 25:  87-9.
Eco-SSLfor Arsenic
                                   18
March 2005

-------
OM, pH        Gal, J. Y. and Bouche, M. B. 1988.  Correlation of Lethal Concentrations of Heavy Metals with
                Tissue Levels of Earthworms. University of France, Montpellier, France (NTIS#ADA199269): 34
                (1988)

OM            Geiszinger, A., Goessler, W., Kuehnelt, D., Francesconi, K., and Kosmus, W.  1998.
                Determination of arsenic compounds in earthworms. Environ. Sci. Technol. 32(15): 2238-2243
                (8-1-1998).

OM, pH        Gill, B. S. and Sandhu, S. S.  1992.  Application of the tradescantia micronucleus assay for the
                genetic evaluation of chemical mixtures in soil and aqueous media. Mutation Research 270(1):
                65-69.

OM, pH        Girling, C. A., Peterson, P. J., and Minski, M. J.  1978. Gold and Arsenic Concentrations in
                Plants as an Indication of Gold Mineralization. Sci Total Environ. 10(1): 79-86 .

FL             Guo, Y., Wang, Z., Lai, Q., Zhang, Y., Xia, W., Yan, H., and Deng, J. 1995. Soil Heavy Metal
                Pollution And Earthworm Isozymes. Yingyong Shengtai Xuebao  6(3): 317-322.

OM, pH        Hall, I. V., Lockhart, C. L., Newbery, R. J., and Wood, G. W.  1971.  Factors Affecting Arsenic
                Injury to Lowbush Blueberry Foliage. Phytoprotection 52(3): 95-99.

Media          Kara, T., Sonoda, Y., andlwai, I.  1977.  Growth Response of Cabbage Plants to Arsenic and
                Antimony Under Water Culture Conditions.  Soil Sci.Plant Nutr.  23(2): 253-256.

Mix            Helgesen, H. and Larsen, E. H. 1998. Bioavailability and Speciation of Arsenic in Carrots Grown
                in Contaminated.  Soil. Analyst.  123(5): 791-796.

Mix            Hiroko, Mikiya.  1993. Effect of Arsenic Pollution on Soil Microbial Population. Soil Sci.Plant
                Nutr. 39(2): 227-235.

FL             Il'In, V. B. and Konarbaeva, G. A. 1993. Forms of arsenic in soil and its accumulation in tomato
                organs. Agrokhimiya : 54-57.

FL             Il'In, V. B.  1994.  Arsenic in orchard soils of kuzbas cities. Agrokhimiya  : 82-85.

OM            Jackson, B. P., Miller, W. P., Schumann, A. W., and Sumner, M. E.  1999. Trace Element
                Solubility from Land Application of Fly Ash/Organic Waste Mixtures. J.Environ.Qual.  28(2):
                639-647.

No Control     Johnson, L. R. and Hiltbold, A. E.  1969. Division S-4-Soil Fertility and Plant Nutrition. Arsenic
                Content of Soil and Crops Following Use of Methanearsonate Herbicides. Soil Sci.Soc.Am.Proc.
                33(2): 279-282.

ERE            Johnson, L. R. and Hiltbold, A. E. 1969. Arsenic Content of Soil and Crops Following Use of
                Methanearsonate Herbicides.  Soil Sci.Soc.Am.Proc . 33(1): 279-282.

Mix            Jones, J. S.  and Hatch, M. B.  1945.  Spray Residues and Crop Assimilation of Arsenic and Lead.
                Soil Sci. 60: 277-288.
ERE
Kanabo, I. A. K. and Gilkes, R. J. 1992. Low-Contaminant Jarosite Waste as a Fertilizer
Amendment. J. Environ. Qual. 21(4):  679-684 .
Eco-SSLfor Arsenic
                                   19
March 2005

-------
FL
Media
Media
OM
FL
Kawashiro, I. and Kondo, T.  1962.  Determination of Trace Amounts of Poisonous Metals in
Foods. II. The Content of Arsenic, Cadmium, Copper, Manganese and Mercury in Rice, Wheat
Flour and Soybeans. Bull. Natl. Inst. Hyg. Sci.  80: 75-87 (JPN).

Khattak, R. A., Haghnia, G. H., Mikkelsen, R. L., Page, A. L., and Bradford, G. R.  1989.
Influence of Binary Interactions of Arsenate, Molybdate and Selenate on Yield and Composition
of Alfalfa. J.  Environ. Qual.  18(3):  355-360.

Khattak, R. A., Page, A. L., Parker, D. R., and Bakhtar, D.  1991. Accumulation and Interactions
of Arsenic, Selenium, Molybdenum and Phosphorus in Alfalfa J. Environ. Qual.  20(1): 165-168.

Kiss, A. S., Oncsik, M., Dombovari, J., Veres, S., and Acs, G.  1992.  Dangers of arsenic
drinking and irrigation water to plants and humans: antagonism of arsenic and magnesium. Ada
Agron.Hung. 41(1/2):  3-9.

Koseki, K.  1988. Suppression of arsenic injury of rice plants by the application of higher
phosphate concn. in culture soln.  Gakujutsu Hokoku - Miyagi-ken Nogyo Tanki Daigaku 36:
15-21.
FL             Kulich, J.  1987.  Basic Nutrition and Phytotoxicity Caused by Arsenic and Lead. Part II.
                Agriculture 33(10): 907-919 (RUS) (1987)

FL             Kulich, J. and Kulichova, R. 1984. Comparison of the Phytotoxicity of Arsenic and Lead
                (Porovnanie Fytotoxicity Arzenu a Olova). Agriculture 30(2):  109-117 (RUS).

FL             Kulich, Jozef.  1988.  The response of cereals to arsenic and lead. Rostl. Vyroba  34(5): 491-498.

FL             Kulich, Jozef.  1990.  Detoxication of arsenic in cereals and legumes by sulfur. Rostl. Vyroba
                36(4): 395-405.

Species         Lancaster, R. J., Coup, M. R., and Hughes, J. W. 1971. Toxicity of Arsenic Present inLakeweed.
                N.Z.Vet.J.  19(7): 141-145.

Media          Lane, I. and Puckett, K. J. 1979. Responses of the Phosphatase Activity of the Lichen Cladina
                rangiferina to Various Environmental Factors Including Metals. Can. J. Bot. 57: 1534-1540.

Mix            Langdon, C. J., Piearce, T. G., Black, S., and Semple, K. T.  1999.  Resistance to
                Arsenic-Toxicity in a Population of the Earthworm Lumbricus rubellus. Soil Biol Biochem. 31:
                1963-1967.
Mix
Lejeune, Katherine, Galbraith, Hector, Lipton, Joshua, and Kapustka, Lawrence A.  1996. Effects
of metals and arsenic on riparian communities in southwest Montana. Ecotoxicology. 5(5):
297-312.
FL
Media
Rev
Li, Xunguang and Li, Xiaoping. 1992. Critical concentration of arsenic in soils of Xiashu loess
area.  Turang (Nanjing) (CHI). 24(6): 302-305.

Liebig, G. F., Jr., Bradford, G. R., and Vanselow, A. P. 1959.  Effects of Arsenic Compounds on
Citrus Plants in Solution Culture.  Soil Sci. 88(6): 342-348.

Liebig, G. F. Jr.  1966.  Arsenic. In: H.D.Chapman (Ed.), Diagnostic Criteria for Plants and Soils,
University of California, Berkeley, CA :  13, 23 (1966)
Eco-SSLfor Arsenic
                                   20
March 2005

-------
Media          Lindner, R. C. and Reeves, E. R. 1942.  Arsenic Injury of Peach Trees: A Disorder Sometimes
                Confused with Western X-Disease. Washington State HortAssoc Proc 38: 37-40.

NoDur         Lindner, R. C.   1943. Arsenic Injury of Peach Trees. ProcAmSocHortSci. 42: 275-279.

FL             Luo, Jinfa, Xia, Zenglu, and Li, Senzhao.  1991.  Chemical behavior of arsenic in purple soil and
                their effects on crops. HuanjingKexueXuebao.  11(3): 269-275.

Media          Machlis, L. 1941. Accumulation of Arsenic in the Shoots of Sudan Grass and Bush Bean. Plant
                Physiol. 16: 521-543.

Species         MacLauchlan, L. E., Borden, J. H., D'Auria, J. M, and Wheeler,  L. A. 1988. Distribution of
                arsenic in MSMA-treated lodgepole pines infested by the mountain pine beetle
                Dendroctonus-ponderosae Coleoptera Scolytidae and its relationship to beetle mortality. Journal
                of Economic Entomology.  81(1): .274-280.

Media          Marin, A. R., Pezeshki, S. R., Masschelen, P.  H., and Choi, H. S.  1993. Effect of dimethylarsenic
                acid (DMAA) on growth, tissue arsenic, and photosynthesis of rice plants. J. Plant Nutr.  16(5):
                865-880.

Cone           Marin, A. R., Masscheleyn, P. H., and Patrick, W. H., Jr. 1993.  Soil Redox-pH Stability of
                Arsenic Species and Its Influence on Arsenic Uptake by Rice. Plant Soil.  152(2): 245-253.

OM            Martin, R. R., Tomlin, A., and Marsello, B. - Arsenic Uptake in Orchard Trees: Implications for
                Dendroanalysis. Chemosphere 41(5): 635-637 (2000)

OM,pH        Mcbee, G. G., Johnson, P. R., and Holt, E. C.  1967. Arsenic Residue Studies on Coastal
                Bermudagrass. Weeds 15: 77-79.

OM, pH        Mclean, H. C., Weber, A. L., and Joffe, J. S.  1944.  Arsenic Content of Vegetables Grown in
                Soils Treated with Lead Arsenate. J. Econ. Entomol. 37(3): 315-316.

Score           Meharg, A. A., Shore, R. F., and Broadgate, K. 1998. Edaphic Factors Affecting the Toxicity and
                Accumulation of Arsenate in the Earthworm Lumbricus terrestris. Environ. Toxicol. Chem. 17(6):
                1124-1131.

Media          Meharg, A. A. and Macnair, M. R.  1991. Uptake, Accumulation and Translocation of Arsenate in
                Arsenate-Tolerant and Non-Tolerant Holcus lanatus L. New Phytol.  117: 225-231.

Mix            Merry, R. H., Tiller, K. G., and Alston, A. M.  1986. The Effects of Soil  Contamination with
                Copper, Lead and Arsenic on the Growth and Composition of Plants. II. Effects of Source of
                Contamination, Varying soil pH, and Prior Waterlogging.  Plant Soil. 95:  255-269.

No Control     Merry, R. H., Tiller, K. G., and Alston, A. M. 1986. The Effects of Contamination of Soil with
                Copper, Lead and Arsenic on the Growth and Composition of Plants. I. Effects of Season,
                Genotype, Soil Temperature and Fertilizers. Plant Soil. 91:115-128.

OM            Miller, R. L.,Bassett, I. P., andYothers, W. W.  1933. Effect of Lead Arsenate Insecticides on
                Orange Trees inFlorida. U.S.Dep.of Agric.Tech.Bull.No.350, Washington, D.C.  20 p.

Mix            Morgan, A. J., Winters, C., and Yarwood, A.  1994. Speed-Mapping Of Arsenic Distribution In
                The Tissues Of Earthworms Inhabiting Arsenious Soil. Cell Biol IntRep.  18(9): 911-914.
Eco-SSLfor Arsenic
21
March 2005

-------
OM, pH        Murphy, H. J. and Goven, M. J.  1966.  Arsenic Residues in Potato Soils and Tubers. Maine
                Farm Res. 14(3): 4-8.

Rev            National Academy of Sciences. Arsenic. Medical and Biologic Effects of Environmental
                Pollutants. Rep.of the Natl.Tech. Advisory Committee to the Secretary of the Interior, Washington,
                D.C. 277-321

Rev            National Research Council of Canada. 1978.  Effects of Arsenic in the Canadian Environment.
                NRCC No. 15391, Associate Committee on Scientific Criteria for Environmental Quality, National
                Research Council of Canada, Ottawa: 352 p. 363.

Media          Ngu, M., Moya, E., and Magan, N. 1998. Tolerance and uptake of cadmium, arsenic and lead by
                Fusarium pathogens of cereals. International Bio deterioration & Biodegradation. 42(1): 55-62.

Media          Nissen, P. and Benson, A. A. 1982. Arsenic Metabolism in Freshwater and Terrestrial Plants.
                Physiol. Plant.  54: 446-450 .

pH             Nyarai-Horvath, F., Szalai, T., Kadar, I., and Csatho, P. 1997.  Germination characteristics of pea
                seeds originating from a field trial treated with different levels of harmful elements.  Ada Agron.
                Hung.  452(147-154).

No Dur         Olson, O. E., Sisson, L. L., and Moxon, A. L.  1940. Absorption of Selenium and Arsenic by
                Plants from Soils Under Natural Conditions. Soil Sci. 50: 115-118.

No Data        Onken, B. M. andHossner, L. R.  1995. Plant uptake and determination of arsenic species in soil
                solution under flooded conditions. J. Environ.  Qual. 24(2): 373-381.

OM, pH        Otte, M. L., Rozema, J., Beek, M. A., Ernst, W. H. O., and Broekman, R. A.  1988. Uptake of
                Arsenic by Vegetation of the Former Rhine Estuary. Proc.Third Int.Conf.Environ. Contam.,
                Sept.1988, Venice, Italy : 529-531.

OM, pH        Otte, M. L., Rozema, J., Beek, M. A., Kater, B. J., and Broekman, R. A.  1990.  Uptake of Arsenic
                by Estuarine Plants and Interactions with Phosphate, in the Field (Rhine Estuary) and Under
                Outdoor Experimental Conditions.  Sci. Total Environ.   97/98:839-854.

Media          Paivoke, A. 1983. Anatomical Response of the Roots of Pea Seedlings to Lead and Arsenate
                Ions. Ann. Bot. Fenn.  20: 307-315.
Media
Paliouris, G. and Hutchinson, T.  1997.  Arsenic, Cobalt and Nickel Tolerances in Two
Populations of Silene vulgaris (Moench) Garcke from Ontario, Canada. New Phytol. 117:
449-459.
No COC        Pavlikova, D., Tlustos, P., Szakova, J., and Balik, J.   1997. b The effect of application of
                potassium humate on the content of cadmium, zinc and arsenic in plants. Rostl. Vyroba 43(10):
                481-486.
Media
Rev
Pepper, L, Galanti, N., Sans, J., and Lopez-Saez, J. F.  1988. Reversible Inhibition of Root
Growth and Cell Proliferation by Pentavalent Arsenic mAllium cepa L. Environ. Exp. Bot.  28(1):
9-18.

Pershagen, G. and Vahter, M.  1979. Arsenic-A Toxicological and Epidemiological Appraisal.
NaturvardsverketRapp.SNVPM 1128, Liber Tryck, Stockholm : 265 .
Eco-SSLfor Arsenic
                                   22
March 2005

-------
Species         Peryea, F. J.  1991.  Phosphate-Induced Release of Arsenic from Soils Contaminated with Lead
                Arsenate. Soil Sci.Soc.Am.J. 55(5): 1301-1306.

Mix            Pilgrim, W.  1995.  Lead, Cadmium, Arsenic, And Zinc In The Ecosystem Surrounding The
                Belledune Lead Smelter. Gov.Rep.Announce.Index (24) (1995)

Mix            Pitten, F. A., Muller, G., Konig, P., Schmidt, D., Thurow, K., and Kramer, A.  1999. Risk
                Assessment of a Former Military Base Contaminated with Organoarsenic-Based Warfare Agents:
                Uptake of Arsenic by Terrestrial Plants. Sci Total Environ. 226: 237-245.

Mix            Porter, E. K. and Peterson, P. J. 1975. Arsenic Accumulation by Plants on Mine Waste (United
                Kingdom). Sci Total Environ.  4(4): 365-371.

Media          Porter, E. K. and Peterson, P. J. 1977. Arsenic Accumulation by Plants on Mine Waste (United
                Kingdom). Environ. Pollut. Ser. A Ecol. Biol. 14(4): 255-265.

OM, pH        Pyles, R. A. and Woolson, E. A. 1982. Quantitation and Characterization of Arsenic Compounds
                in Vegetables Grown in Arsenic Acid Treated Soil. J.Agric.Food Chem.  30(5): 866-870 .

No Data        Reed, J. F. and M. B. Sturgis.  1936.  Toxicity from Arsenic Compounds to Rice on Flooded Soils.
                J. Am. Soc. Agron. 28: 432-436.

Species         Riedel, G. F. and Valette-Silver, N.  2002. Differences in the Bioaccumulation of Arsenic by
                Oysters from Southeast Coastal US and Chesapeake Bay: Environmental Versus Genetic Control.
                Chemosphere.  49(1): 27-37 (2002)

OM            Robinson, E. L. 1975.  Arsenic in Soil with Five Annual Applications of MSMA. Weed Sci.
                23(5): 341-343.

Media          Rocovich, S. E. and West, D. A. 1975.  Arsenic Tolerance in a Population of the Grass
                Andropogon scoparius Michx. Science 188: 263-264 (1975)

OM, pH        Rosehart, R. G. and Lee, J. Y. 1973.  The  Effect of Arsenic Trioxide on the Growth of White
                Spruce Seedlings.  Water Air Soil Pollut.  2:439-443.

Rev            Sandberg, G. R. and Allen, I. K. 1975. A Proposed Arsenic Cycle in an Agronomic Ecosystem.
                In: E.A. Woolson (Ed.), Arsenical Pesticides, ACS Symp.Ser.No. 7 : 124-147 (1975)

FL             Savory, J. and Wills, M. R.  Arsenic. In: E.Merian (Ed.), Metals in the Environment: Distribution,
                Analysis and Biological Relevance, Chapter 3, Verlag: Weinheim,  West Germany

OM, pH        Sheppard, M. I., Thibault, D. H., and Sheppard, S. C. 1985  Concentrations and Concentration
                Ratios of U, As and Co in Scots Pine Grown in a Waste-Site Soil and an Experimentally
                Contaminated Soil.  Water Air Soil Pollut. 26(1): 85-94 .

Rev            Sheppard, S. C. 1992.  Summary of Phytotoxic Levels of Soil Arsenic. Water Air Soil Pollut.
                64(3/4): 539-550.

ERE            Shinonaga, Taeko and Ambe, Shizuko. 1998. Multitracer study on absorption of radionuclides in
                atmosphere-plant model system. Water Air Soil Pollut.  10(1-4): 93-103.

OM,pH        Sieczka, J. B. andLisk, D. J.  1971.  Arsenic Residues in Red Clover. Am.PotatoJ. 48: 395-397.

OM,pH        Sihlbom,E.  1956.  Arsenic in Potato Tubers. Sveriges  Utsadesforen  Tids 66:199-201(1956)
Eco-SSLfor Arsenic
23
March 2005

-------
OM            Sihlbom, E. and Fredriksson, L.  1960.  Yield and Arsenic Content in Potatoes Grown in Soil with
                Different Amounts of Arsenite. Svehges Utsadesforen Tids 70: 312-317 .

pH             Simon, T., Mikanova, O., and Kubat, J.  1998. The Effect of Addition of Inorganic Ni and As
                Compounds on the Growth of Radish and Activities of Soil Microorganisms. Rostl. Vyroba.
                44(4): 187-192.

OM, pH        Singh, B. R. and Steinnes, E. 1976. Uptake of Trace Elements by Barley in Zinc-Polluted Soils:
                2. Lead, Cadmium, Mercury, Selenium, Arsenic, Chromium and Vanadium in Barley. Soil Sci.
                121(1):  38-43 .

Rev            Slooff, W., Haring, B. J. A., Hesse, J. M., Janus, J. A., and Thomas, R. 1990.  Integrated Criteria
                Document Arsenic. RIVM Rep.No.758701002, Natl.Inst.of Public Health and Environ.Prot,
                Bilthoven, Netherlands : 130 p. (OUT).

OM, pH        Small, H. G., Jr. and McCants, C. B.  1962. Residual Arsenic  in Soils and Concentration in
                Tobacco. Tobacco Sci. 6: 34-36.
ERE
Rev
Mix
Small, H. G., Jr. and McCants, C. B. 1962. Influence of Arsenic Applied to the Growth Media on
the Arsenic Content of Flue-Cured Tobacco. Agron J. 54: 129-133.

Smith, E., Naidu, R., and Alston, A. M. 1998. Arsenic in the Soil Environment:  A Review.
AdvAgron. 64: 149-195 .

Speir, T. W., Ross, D. J., Feltham, C. W., Orchard, V. A., and Yeates, G. W.  1992. Assessment
of the Feasibility of Using CCA (Copper, Chromium and Arsenic)-Treated and Boric Acid-Treated
Sawdust as Soil Amendments. II. Soil Biochemical and Biological Properties. Plant Soil.  142(2):
249-258.
No COC        Speir, T. W., August, J. A., and Feltham, C. W.  1992. Assessment of the feasibility of using cca
                copper chromium and arsenic-treated and boric acid-treated sawdust as soil amendments i. Plant
                growth and element uptake. Plant Soil 142(2): 235-248.

Media          Stakman, E. C., Stevenson, F. V., and Wilson, C. T. 1946. Adaptation of Monosporidial Lines of
                Ustilago zeae to Arsenic. Phytopathology  36: 411 (ABS).

OM, pH        Steevens, D.  R., Walsh, L. M., and Keeney, D. R.  1972. Arsenic Residues in Soil and Potatoes
                from Wisconsin Potato Fields - 1970. Pestic.Monit.J.  6(2): 89-90 .

Score           Steevens, D.  R., Walsh, L. M., and Keeney, D. R. 1972. Arsenic Phytotoxicity on a Plainfield
                Sand as Affected by Ferric Sulfate or Aluminum Sulfate. J. Environ. Qual.  1(3): 301-303.

OM, pH        Stewart, J.  and Smith, E. S.  1922.  Some Relations of Arsenic to Plant Growth: Part 2. 5*0/7 Sci.
                14(2): 119-126.

No Dur         Stijve, T., Vellinga, E. C., and Herrmann, A. 1990. Arsenic Accumulation in Some Higher Fungi.
                Persoonia  14: 161-166.

NoTox         Tang, T. and Miller, D. M. 1991. Growth and Tissue Composition of Rice Grown in Soil Treated
                with Inorganic Copper Nickel and Arsenic.  Commun .Soil Sci. Plant Anal.  22(19/20):
                2037-2046.
Eco-SSLfor Arsenic
                                   24
March 2005

-------
OM            Thompson, A. H. and Batjer, L. P. 1950. Effect of Various Soil Treatments for Correcting
                Arsenic Injury of Peach Trees. Soil Sci.  69: 281-290.

No Tox         Thompson, M. E. and Johnston, A. M.  1958. Total Sulphydryl Content of Embryos of
                Arsenic-Resistant and Sensitive Strains of the Blue Tick Boophilus decoloratus.  Nature. 181:
                647-648.

No Stats        Tlustos, P., Balik, I, Szakova, J., and Pavlikova, D. 1998. The accumulation of arsenic in radish
                biomass when different forms of As were applied in the soil (Czech). RostlinnaVyroba. 44(1): 7-
                13.
Mix
Mix
Mix
Media
Rev
Rev
Rev
Media
Mix
Score
Media
Media
Tlustos, P., Pavlikova, D., Balik, J., Szakova, J., Hanc, A., and Balikova, M. 1998. The
accumulation of arsenic and cadmium in plants and their distribution [Czech].  Rostlinna Vyroba
44(10): 463-469.

Tlustos, P., Balik, J., Pavlikova, D., and Szakova, J.  1997. The uptake of cadmium, zinc, arsenic
and lead by chosen crops. Rostl.Vyroba.  43(10): 487-494.

Tolle, D. A., Arthur, M. F., Chesson, J., and Van Voris, P. 1985. Comparison of Pots Versus
Microcosms for Predicting Agroecosystem Effects due to Waste Amendment.
Environ.Toxicol.Chem. 4(4): 501-509.

Tso, T. C., Sorokin, T. P., and Engelhaupt, M. E. 1973.   Effects of Some Rare Elements on
Nicotine Content of the Tobacco Plant. Plant Physiol. 51: 805-806.

Tsutsumi, M. 1981.  Arsenic Pollution in Arable Land. In: K.Kitagishi and I.Yamane (Eds.),
Chapter 14, Heavy Metal Pollutin in Soils of Japan, Japan Scientific Soc.Press, Tokyo : 181-192
(1981)

Valberg, P. A., Beck, B. D., Bowers, T. S., Keating, J. L., Bergstrom, P. D., and Boardman, P. D.
1997. Issues In Setting Health-Based Cleanup Levels For Arsenic In 5*0/7. Regul Toxicol
Pharmacol. 26(2): 219-229.

Vetter, J. 1994. Data on Arsenic and Cadmium Contents of Some Common Mushrooms. Toxicon
32(1): 11-15.

Villalobos-Pietrini, R., Flores-Marquez, A. R., Sanchez, M., and Gomez-Arroyo, S. 1990.
Micronuclei induced in tradescantia by arsenic. Rev Int Contam Ambient.  6(1): 75-78.

Wang, Zhenzhong, Zhang, Youmei, Hu, Juelian, Zheng, Yunyou, Hu, Zhaoyang, Guo, Yongcan,
Lai, Qing, Yan, Hengmei, and Deng, Jifu. 1994. Effect of heavy metals in soil on earthworms
(Opisthopora).  HuanjingKexueXuebao.  14(2): 236-243.

Weaver, R. W., Melton, J. R., Wang, D.,  and Duble, R. L. 1984. Uptake of Arsenic and Mercury
from Soil by Bermuidagrass Cynodon dactylon.  Environ. Pollut.  33:  133-142.

Wells, B. R. and Gilmour, J.  T. 1977. Sterility in Rice Cultivars as Influenced by MSMA Rate
and Water Management. AgronJ. 69: 451-454.

Wetzel,  A. and Werner, D.  1995. Ecotoxicological Evaluation of Contaminated Soil Using the
Legume Root Nodule Symbiosis as Effect Parameter. Environ. Toxicol. Water Qual. 10(2):
127-133.
Eco-SSLfor Arsenic
                                  25
March 2005

-------
Mix            Wiersma, D., Van Goor, B. I, and Van der Veen, N. G. 1986. Cadmium, Lead, Mercury, and
                Arsenic Concentrations in Crops and Corresponding Soils in The Netherlands. J. Agric. Food
                Chem.  34: 1067-1074.

Mix            Wilkins, C. 1997. The Uptake of Copper, Arsenic and Zinc by Miscanthus-Environmental
                Implications for Use as an Energy Crop. Biomass and Energy Crops, April 7-8, 1997, Royal
                Agricultural College, Cirencester : 335-340 (1997)

Score           Woolson, E. A., Axley, J. H., and Kearney, P. C.  1973. The Chemistry and Phytotoxicity of
                Arsenic in Soils: II.  Effects of Time and Phosphorus. Proc. Soil Sci. Soc. Am. 37:  254-259.

No Data        Woolson, E. A.  1973. Arsenic Phytotoxicity and Uptake in Six Vegetable Crops.  Weed Sci.
                21(6):  524-527.

Score           Woolson, E. A.  1972. Effects of Fertiliser Materials and Combinations on the Phytotoxicity,
                Availability and Content of Arsenic in Corn (Maize). J. Sci. Food Agric. 23: 1477-1481.

OM            Woolson, E. A., Axley, J. H., and Kearney, P. C.  1971. Correlation Between Available Soil
                Arsenic, Estimated by Six Methods, and Response of Corn (Zea mays L.). Soil Sci.Soc.Am.Proc.
                35(1): 101-105(1971)

No Data        Woolson, E. A., Axley, J. H., and Kearney, P. C.  1971. The Chemistry and Phytotoxicity of
                Arsenic in Soils: I. Contaminated Field Soils.  Soil Sci Am Proc.  35: 938-943.

Mix            Wyttenbach, A., Bajo, S., and Tobler, L.  1996.  Arsenic Concentrations in Successive Needle Age
                Classes of Norway Spruce (Picea abies (L.) Karst).  Fresenius' J.Anal.Chem. 354(5/6): 668-671.

No Dur         Wyttenbach, A., Bajo, S., Furrer, V., Langenauer,  M., and Tobler, L. 1997. The accumulation of
                arsenic, bromine and iodine in needles of norway spruce (Picea abies (1.) Karst.) At sites with low
                pollution.  Water Air Soil Pollut.  94(3-4): 417-430.

FL             Xi, Yuying, Li, Feng, and Fan, Jiaren.  1989. Rule of accumulation and movement of chromium
                and arsenic in soil and the inside of plants. Shanxi DaxueXuebao, Ziran Kexueban.  12(4):
                472-480.

Media          Xie, Zheng Miao and Huang, Chang Yong. 1998.  Control of arsenic toxicity in rice plants grown
                on an arsenic-polluted paddy soil. Commun. Soil Sci.Plant Anal.  29(15/16): 2471-2477.

FL             Xie, Zhengmiao, Zhu, Zuxiang, Yuan, Keneng, and Huang, Changyong.  - Effect of birnessite
                (.delta.-MnO2) on oxidation of arsenic(III) in soils. Huanjing Huaxue 8(2): 1-6 (1989)

FL             Xie, Zhengmiao, Zhu, Zuxiang, Yuan, Keneng, and Huang, Changyong.  1991. Study on critical
                arsenic contents causing toxicity towards rice plants  in different soils. Zhongguo Huanjing Kexue
                11(2): 105-108.

Mix            Yeates, G. W., Orchard, V A., and Speir, T. W. 1995.  Reduction In Faunal Populations And
                Decomposition Following Pasture Contamination By A Cu-Cr-As Based Timber Preservative.
                Acta Zoo/. Fenn. (196): 297-300.

OM, pH        Yothers, M. A. and Carlson, F. W. - Effect of DDT on the Green Peach Aphid and Its Coccinellid
                Predators. J.Econ.Entomol. 41(3): 515-516 (1948)
Eco-SSLfor Arsenic
26
March 2005

-------
Species         Zaman, K., MacGill, R. S., Johnson, J. E., Ahmad, S., and Pardini, R. S.  - An Insect Model for
                Assessing Oxidative Stress Related to Arsenic Toxicity. Arch.Insect Biochem.Physiol. 29(2):
                199-209 (1995)

FL             Zyrin, N. G., Kovnatskii, E. F., Roslyakov, N. P., Ryakhovskii, A. V., and Samonov, A. M.  -
                Determination of Arsenic and Antimony in Plants. Yad.-Fiz.Metody Anal.Kontrole Okruzh.Sredy,
                Tr.Vses.Soveshch.  228-231(1985)
7.4    References Used for Derivation of Wildlife TRVs

Bencko, V. 1972. oxygen consumption by  mouse  liver homogenate during drinking water arsenic exposure,  ii.
J.Hyg.Epidemiol.,Microbiol.,Immunol.   16(1): 42-6.  RefID:  15471

Benes, B. and Bencko, V. 1981. content of lipids and esterified fatty acids in the liver of mice exposed to arsenic
in drinking   water.  J. Hyg. Epidemiol., Microbiol., Immunol.   25(4): 384-92. RefID:  15288

Biswas, U., Sarkar, S., Bhowmik, M. K., and Roy, S. clinicopathological profile of induced chronic arsenic toxicity
in Goats.  Indian Journal of Animal Sciences; 68 (4).  1998. 320-323.  RefID:  15322

Biswas, U. S. Sarkar M. K. Bhowmik A. K. Samanta and S. Biswas. 2000. chronic toxicity of arsenic in goats:
clinicobiochemical changes pathomorphology and tissue  residues.  Small Ruminant Research  38(3): 229-235.
RefID: 25916

Blakley, BR, Sisodia, CS, and Mukkur, TK. 1980. the effect of methylmercury, tetraethyl lead, and sodium arsenite
on the humoral immune response in mice.   Toxicol. Appl. Pharmacol. 52(2): 245-254. RefID:  14598

Brown, M. M., Rhyne, B. C., and Goyer, R. A.  1976.  intracellular effects of chronic arsenic administration on renal
proximal tubule cells.  J Toxicol Environm Health.  1(3):  505-514. RefID:  4

Byron, W. R., Bierbower, G. W., Brouwer, J. B., and Hansen, W. H.  1967. pathologic changes in rats and dogs
from two-year feeding of sodium arsenite or sodium arsenate.   Toxicol. Appl.Pharmacol.  10(1):  132-147.  RefID:
2

Cabe, P. A., Carmichael, N. G., and Tilson, H. A. 1979.  effects of selenium, alone and in combination with silver
or arsenic, in rats.  Neurobehav Toxicol.  1(4): 275-8. RefID:  1244

Camardese, Michael B., Hoffman, David J., LeCaptain, Leonard J., and Pendleton, Grey W. effects of arsenate on
growth and physiology in mallard  ducklings.  Environ. Toxicol. Chem. (1990)  9(6): 785-95. RefID: 5747

Carmignani, M., Boscolo, P., and Castellino, N.  1985. metabolic fate and cardiovascular effects of arsenic in rats
and rabbits chronically exposed to trivalent and pentavalent arsenic.   Arch.  Toxicol. Suppl. (8): (Recept. Other
Targets Toxic Subst), 452-5. RefID:  15174

Carmignani, M., Boscolo, P., and lannaccone, A. effects of chronic exposure to arsenate on the cardiovascular
function of rats.  Br. J. Ind. Med (1983)  40(3):  280-4. RefID: 15249

 Chaudhuri, Aditi Nag, Basu, Srabanti, Chattopadhyay, Sukumar, and Gupta,  S. Das.  effect  of high arsenic content
in drinking   water on rat  brain.  Indian J. Biochem. Biophys. (1999)  36(1):  51-54. RefID:   15033

Chiou  WenShyg, P., Chen, K. L., and Yu, B.  1998. effect of dietary organic arsenicals and cupric sulfate on
copper toxicity, liver accumulation and residue in eggs and excreta of laying Hens.  Animal Feed Science and
Eco-SSL for Arsenic                               27                                      March 2005

-------
Technology. 73(1-2)  RefID:  2049

Cobo, Jose M, Aguilar, Maria V., and Martinez, Maria C.  effect of chronic cr3+ administration and its interaction
with dietary as3+on glucose tolerance in wistar rats  .  Nutr. Res.  (N. Y.) (1995)   15(4):  555-64. RefID:  15198

Coulson, EJ, Remington, RE, and Lynch, KM.  1935. metabolism in the rat of the naturally occurring arsenic of
shrimp as compared with arsenic trio xide.  J. Nutr.  10: 255-270. RefID:  14603

Fowler, BA, Woods, JS, and Schiller, CM.  1977. ultrastructural and biochemical effects of prolonged oral arsenic
exposure on liver mitochondria of rats.  Environ. Health Perspect.  19:  197-204. RefID:  14569

Fowler, Bruce A. and Woods, James S. the effects of prolonged oral  arsenate exposure on liver mitochondria of
mice : morphometric and biochemical studies.  Toxicol. Appl. Pharmacol. (1979)   50(2):  177-87. RefID:  15358

Franke, KW and Moxon, AL.  1937. the toxicity of orally ingested arsenic, selenium, tellurium,  vanadium and
molybdenum.  J. Pharmacol. Exp. Ther. 61:  89. RefID: 14508

Fuentes, N, Zambrano, F, and Rosenmann, M. 1981. arsenic contamination: metabolic effects and localization in
rats.  Comp. Biochem. Physiol.  70C:  269-272. RefID: 14570

Garcia-Vargas, G., Cebrian, M. E.,  Albores, A., Lim, C. K., and De Matteis, F.  1995. time-dependent porphyric
response in mice subchronically exposed to arsenic.   Human & Experimental Toxicology  14(6): 475-83. RefID:
15530

Ghosh, Debidas, Chattopadhyay, Sandip, and Debnath,  Jogen. effect of sodium arsenite on adrenocortical activity in
immature female rats  : evidence of dose-dependent response.  J. Environ. Sci. (China) (1999)  11(4):  419-422 .
RefID: 15011

Glattre, E., Mravcova, A., Lener, J., Vobecky, M., Egertova, E., and Mysliveckova, M. 1995. study of distribution
and interaction of arsenic and selenium in rat thyroid.   Biol Trace Elem Res. 49(2-3):  177-86.  RefID:  11361

Healy,  Sm, Casarez, Ea, Ayala-Fierro, F, and Aposhian, HV. 1998.  enzymatic methylation of arsenic compounds.
Toxicol. Appl. Pharmacol.  148:  65-70. RefID: 14543

Hoffman, D. J., Sanderson, C. J., LeCaptain,  L. J., Cromartie, E., and Pendleton, G.  W. 1992.  interactive effects of
arsenate, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings. Arch Environ
Contam Toxicol. 22(1): 55-62. RefID: 1376

Holcman, A. and Stibilj, V. arsenic residues in eggs from laying hens fed with a  diet  containing arsenic (iii)
oxide.   Arch. Environ.  Contam.  Toxicol. (1997)  32(4): 407-410. RefID:  5305

Howell, G. O. and Hill,  C. H. 1978. biological interaction of selenium with other trace elements in chicks.
Environ Health Perspect.  25:  147-50.  RefID:  1387

Hughes, Michael F. and Thompson, Daniel J.  subchronic dispositional and lexicological effects  of arsenate
administered in drinking  water  to  mice.   J. Toxicol. Environ. Health (1996) 49(2): 177-196. RefID: 15160


Hunder, G., Schaper, J., Ademuyiwa, O., and Elsenhans, B. species differences in arsenic-mediated renal copper
accumulation: a comparison between  rats  ,  mice  and guinea pigs.   Hum. Exp.  Toxicol.  (1999)  18(11): 699-
705. RefID: 15007
Eco-SSL for Arsenic                               28                                      March 2005

-------
Itoh, T, Zhang, YF, Murai, S, Saito, H, Nagahama, H, Miyate, H, Saito, Y, and Abe, E.  1990. the effect of arsenic
trioxide on brain monoamine metabolism and locomotor activity of mice.  Toxicol. Letters.  54: 345-353. Ref ID:
14577

Kanisawa, M. and Schroeder, H. A. 1969.  life term studies on the effect of trace elements on spontaneous tumors in
mice and rats.   Cancer Res.  29(4): 892-895. Ref ID:  3701

Kanisawa, M. and Schroeder, H. A. 1969.  renal arteriolar changes in hypertensive rats given cadmium in drinking
water.  Experimental and Molecular Pathology  10(1): 81-98.  Ref ID: 15061

Kanisawa, M. and H. A. Schroeder. 1967.  life term studies on the effects of arsenic, germanium, tin, and vanadium
on spontaneous tumors in mice.  Cancer Research. 27: 1192-1195. Ref ID: 20979

Kiyono, S., Hasui, K., Takasu, K., and Seo, M. toxic effect of arsenic trioxide in infant rats.   J. Physiol. Soc. Jpn.
36(7): 253-254; 1974.(5 References)  Ref ID: 15427

Mahaffey, KR and Fowler, BA.  1977. effects of concurrent administration of lead, cadmium, arsenic in the rat.
Environ. Health Perspect.  19:  165-171. Ref ID:  14580

Mercado, R. C. and Bibby, B. G. 1973.  trace element effects  on enamel pigmentation incisor growth and molar
morphology in rats.   ARCH ORAL BIOL.  18(5): 629-635. Ref ID: 757

Morgareidge, K. 1963.  metabolismof two forms of dietary arsenic by the rat.   J. Agric. Food Chem.  11: 377.
RefID: 14414

Morris, H. P., Laug, E. P., Morris, H. J.,  and Grant, R. L.  growth and reproduction of rats fed diets containing lead
acetate and arsenic trioxide and the lead and arsenic content of newborn and suckling Rats.   JPharmacol Exp Ther
64:420-445,1938 RefID: 15125

Morrison, L. L. and Chavez, E. R.  1983. selenium-arsenic interaction in the weanling pig.   Canadian Journal of
Animal Science  63(1):  239-246. RefID:  15709

Nagaraja, T. N. and Desiraju, T. effects  on operant learning and brain acetylcholine esterase activity in rats
following chronic inorganic arsenic intake.  Hum. Exp. Toxicol. (1994)  13(5): 353-6.  RefID:  15216

Nagaraja, TN and Desiraju, T.  1993. regional alterations in the levels of brain biogenic amines, glutamate, gaba,
and gad activity due to chronic consumption of inorganic arsenic in developing and adult rats/.  Bull. Environ.
Contain. Toxicol.  50: 100-107.  RefID: 14546

Neiger, R. D. and Osweiler, G. D.  1992. arsenic concentrations in tissues and body fluids of dogs on chronic low-
level dietary sodium arsenite.  Journal Of Veterinary Diagnostic Investigation. 4(3): 334-337. RefID:  15703

Neiger, RD and Osweiler, GD.  1989.  effect of subacute low level dietary sodium arsenite on dogs.  Fund. Appl.
Toxicol.  13: 439-451.  RefID:  14583

Nemec, Mark D., Holson, Joseph F., Farr, Craig H., and Hood, Ronald D. developmental toxicity assessment of
arsenic acid in mice   and rabbits.   Reprod. Toxicol. (1998)  12(6): 647-658.  RefID:  15057

Nielsen, F. H., Hunt, C. D., and Uthus, E. O.  1980. interactions between essential trace and ultratrace elements.
Annals of the New York Academy of Sciences  355: 152-64. RefID: 15690

Obermeyer, B. D., Palmer, I. S., Olson, O. E., and Halverson, A. W.  1971. toxicity of trimethylselenonium chloride
Eco-SSL for Arsenic                               29                                      March 2005

-------
in the rat with and without arsenite.  Toxicol Appl Pharmacol.  20(2):  135-46. RefID:  12934

Palmer, I. S., Thiex, Nancy, and Olson, O. E.  dietary  selenium and arsenic effects in  rats.   Nutr. Rep. Int. (1983)
27(2):  249-57.  RefID:  15262

Savabieasfahani, M, Lochmiller, RL, Rafferty, DP, and Sinclair, JA.  1998.  sensitivity of wild cotton rats (sigmodon
hispidus) to the immunotoxic effects of low-level arsenic exposure.  Arch. Environ. Contain. Toxicol. 34:  289-296.
RefID: 14556

Schiller, Carol M., Fowler, Bruce A., and Woods, James S. effects of arsenic onpyruvate dehydrogenase activation.
 Environ. Health Perspect. (1977) : 19,205-7.  RefID:  15397

Schiller, Carol M., Walden, Ramsey, and Fowler, Bruce A. interaction between arsenic and alloxan-induced
diabetes, effects on rat  urinary enzyme levels.   Biochem. Pharmacol. (1981) 30(2): 168-70. RefID: 15324

Schmolke, G., Elsenhans, B., Ehtechami, C., and Forth, W. arsenic-copper interaction in the kidney of the  rat.
Hum. Exp.  Toxicol. (1992)  11(5): 315-21. RefID: 15264

Schroeder, H. A. and Balassa, J. J. 1967.  arsenic, germanium, tin and vanadium in mice: effects on growth, survival
and tissue levels.  J. Nutr.  92(2): 245-252. RefID: 3084

Schroeder, H. A., Kanisawa, M., Frost, D.  V., and Mitchener, M.  1968. germanium, tin, and arsenic in rats: effects
on growth, survival, pathological lesions, and life span.  JNutr. 96: 37-45. RefID:  7

Schroeder, H. A. and Mitchener, M.  1971. toxic effects of trace elements on the reproduction of mice and rats.
Arch.Environ.Health.  23:  102-106. RefID:  66

Schroeder, Henry A.  1968. serum cholesterol levels in  rats  fed thirteen trace elements.  J. Nutr.  94(4):  475-80
.  RefID:  15506

Seidenberg, J. M., Anderson, D. G., and Becker, R. A. 1986. validation of an in vivo developmental  toxicity screen
in the mouse.   Teratog Carcinog Mutagen.  6:  361-374.  RefID:  113

Skalnaya, M. G., Zhavoronkov, A. A., Kalinina, 1.1., and Skalny, A. V. characteristic of thymus in newborn  mice
after chronic exposure of their mothers to sodium arsenite.   Trace Elem. Electrolytes  (1996)   13(2):  88-91  Ref ID:
15167

Stanley, T. R. Jr., Spann, J. W., Smith, G. J., and Rosscoe, R. 1994. main and interactive effects of arsenic and
selenium on mallard reproduction and duckling  growth and survival.  Archives of Environmental Contamination
and Toxicology.  26(4):  444-451. RefID:  1570

Tice, RR, Yager, JW, Andrews, P, and Crecelius, E. 1997. effect of hepatic metyl donor status on urinary excretion
and dna damage in bc3fl mice treated with sodium arsenite.  Mutation Res.  386:  315-334.  RefID:  14589

Tripathi, N, Kannan, GM, Pant, BP, Jaiswal, DK, Malhotra, PR, and Flora, SJS.  1997. arsenic-induced changes in
certain neurotransmitter levels and their recoveries following chelation in rat whole brain. Toxicol. Letters. 92:
201-208. RefID: 14590

Uthus, Eric O. and Nielsen, Forrest H.  1985.  effects in chicks of arsenic, arginine, and zinc and their interaction on
body weight, plasma uric acid, plasma urea, and kidney arginase activity.   Biol. Trace Elem. Res.   7(1): 11-20 .
RefID: 6188
Eco-SSL for Arsenic                                30                                       March 2005

-------
Valkonen, S, Savolainen, J, and Javisalo, J.  1983.  arsenic distribution and neurochemical effects in peroral sodium
arsenite exposure of rats.  Bull. Environ. Contam.  Toxicol.  30(3): 303-308. RefID:  14593

Vreman, K., Van, D. E. R. Veen Ng, Van, D. E. R. Molen Ej, and De, Ruig Wg.  1988.  transfer of cadmium lead
mercury and arsenic from feed into tissues of fattening bulls chemical and pathological data.  Neth JAgric Sci.
36(4):  327-338. RefID: 471

Whitworth, Molly R., Pendleton, Grey W., Hoffman, David J., and Camardese, Michael B. effects of  dietary
boron and arsenic on the  behavior  of  mallard   ducklings.  Environ. Toxicol. Chem. (1991)   10(7):  911-16:
0730-7268. RefID: 5690

Woods, James S. and Fowler, Bruce A. altered regulation of mammalian hepatic heme biosynthesis and urinary
porphyrin excretion during prolonged exposure to sodium arsenate.  Toxicol. Appl. Pharmacol. (1978) 43(2):
361-71. RefID:  15387
7.5    References Rejected for Use in Derivation of Wildlife TRVs

These references were reviewed and rejected for use in derivation of the Eco-SSL. The
definition of the codes describing the basis for rejection is provided at the end of the reference
sections.

Diss            Arsenic: an analytical procedure to determine its total content in biological samples and signs of
                its deprivation in rats and chicks.   788794 ORDER NO: AAD82-20750

Diss            Characterization and comparison of mitochondria! atpase and adenine nucleotide transport activity
                in mitochondria from rat liver and neoplastic tissues of different growth rates.   760425  ORDER
                NO: AAD81-23882

Diss            Characterization, fate and environmental risk assessment of microbial, elemental and toxic
                components of fractionated broiler litter during storage and reutilization.   01295605 ORDER
                NO: AAD93-16361

Diss            Crystallographic studies of transport proteins and ligands (thiobacillus ferrooxidans, didelphins
                virginiana, multiplewavelength anomalous dispersion).  01695894 ORDER NO: AAD99-23629

Diss            Ecology and toxicology of arsenic in contaminated grassland.  0996661  ORDER NO: Not
                Available from University Microfilms Int'l.

Diss            effects of chronic dietary inorganic arsenic in dogs.   0966997 ORDER NO: AAD87-21915

Diss            effects of stripped oil shale retort water on fishes, birds, and mammals.  01265899 ORDER NO:
                AAD84-08915

Diss            electrochemical synthesis and structural characterization of zintl anion clusters produced via the
                cathodic dissolution of telluride electrodes.  01378472 ORDER NO: AAD94-29162

Diss            factors affecting the toxicity and metabolism of organic arsenicals (roxarsone, copper, cysteine).
                1003496 ORDER NO: AAD85-02122

Diss            heavy metal bioaccumulation in great basin submersed aquatic macrophytes.  01363274 ORDER


Eco-SSL for Arsenic                               31                                       March 2005

-------
                NO: AAD94-18488

No Oral        letter from smelter environmental research association to usepa submitting two research reports on
                arsenic compounds, cadmium compounds and calcium sulfate with attachments.  EPA/OTS; Doc
                #88-7800150

Unrel           Multielement Geochemical Exploration Data for the Cove Known Geothermal Resource Area,
                Beaver andMillard Counties, Utah\ AU-

CP             newer trace elements - vanadium (v) and arsenic (as): deficiencyand possible metabolic roles. .|
                au.   Trace Element Metabolism in Man and Animals - 3

NoCOC        news about chemicals.  IRPTC Bull. V8,N1, P 17(16)

Diss            processes controlling arsenic mobility in natural and engineered systems (drinking water,  los
                angeles, water treatment, geothermal.  01603177 ORDER NO: AAD98-03506

No Oral        Tadlock, Charles H. and Aposhian, H. Vasken.  protection of mice  against the  lethal  effects of
                sodium arsenite by 2,3 dimercapto-1-propanesulfonic acid and dimercaptosuccinic acid.
                Biochem. Biophys. Res. Commun. (1980)  94(2): 501-7.

Diss            the role of activated charcoal in the treatment of acute arsenic poisoning:  an in vivo study.
                01201519  ORDER NO: AAD13-46055
Diss


FL


Unrel

Diss
Stress-induced proteins in rat myoblasts (arsenic, heat shock, phosphorylation, gel electrophoresis,
two-dimensional.   887311 ORDER NO: AAD85-14020

Study on the maximum permissible concentration of arsenic compounds in drinking   water.
Huan ChingK'o Hsueh (1981)  2( 3):  184-8 CODEN: HCKHDV; ISSN: 0250-3301.

Synergistic teratogenic effects of arsenic and hyperthermia in.

systemic indicators of inorganic arsenic toxicity in several species.  1015071 ORDER NO:
AAD13-33254
No COC        1949.Thiouracil Administration and Thyroidectomy in Experimental Polyarthritis of Rats  : 8p.

Surv            1958.Regional Monitoring Activities, May 1958.  HW-56226

Surv            1916.Rocky Mountain Arsenal Bird Kill (Entomological Special Study).  RMA-83020R03

An Prod        1980.  market milk technology and equipment; milk products microbiology,physico-chemical
                properties and analysis. india, national dairy research institute: annualreport
                1979.    211-219.

FL             1980.  [a study on the combined toxicity of ddt, 666, as, hg and cr (author's transl)].  Chung-Hua
                Yu Fang i Hsueh Tsa Chih  14(2): 86-8.

Unrel           1982. Use of Isotopes to Detect Moderate Mineral Imbalances in Farm Animals. Results of a CO-
                Ordinated Research Programme on the Use of Isotope Techniques for Detection of Moderate
                Mineral Imbalances in Farm Animals Organized by the Joint FAO/IAEA Division of Isotope and
                Radiation Applications of Atomic Energy for Food and Agricultural Development and Presented
Eco-SSLfor Arsenic
                                  32
March 2005

-------
                at a Research CO-Ordination Meeting Held in Nicosia, Cyprus, 6-10 October 1980. IAEA-
                TECDOC-267; CONF-8010327-

Unrel           1987. Toxicology and biochemistry of acaricides.  report 1984-86, division of
                tropical animal sciences,csiro.    25-31.

No Dose        1989. Superfund Record of Decision (EPA Region 5): Ott/Story/Cordova Chemical Site, North
                Muskegon, Michigan (First Remedial Action), September 1989.  EPA/ROD/R05-89/111

Mix            1993. NTP technical report on toxicity studies of a chemical mixture of 25 groundwater
                contaminants administered in  drinking   water to f344/n  rats and b6c3fl  mice.   Natl.
                Toxicol. Program Toxic. Rep. Ser.   35:  184 pp.

Unrel           1996. Environmental Cleanup: Progress in Resolving Long-Standing Issues at the Rocky
                Mountain Arsenal

Drug           aAbdul-Ghani, A. S., Attwell, P. J., and Bradford, H. F.  1998. the effect of 2-amino-3-
                arsonopropionate and 2-amino-4-arsonobutyrate on the development and maintenance of amygdala
                kindled seizures.  InternationalJournalofNeuroscience  96(3-4):  255-67.

Org met        Abdo, K. M, Elwell, M. R., Montgomery, C. A., Thompson, M. B., Thompson, R. B., and
                Prejean, J. D. 1989.  toxic responses in 1344 rats and b6c3f 1 mice given roxarsone in their diets
                for up to  13 weeks.   Toxicology Letters 45(1): 55-66.

FL             Abdrashitova, S. A., Mynbaeva, B. N., Aidarkhanov, B. B., Abdullina, G. G., and Ilialetdinov, A.
                N. 1989. relationship between arsenite oxidation and lipid oxidation during arsenite-oxidizing
                microorganism growth.  Doklady Akademii NaukSssr  304(3):  737-740.

An Prod        Abrahams, P. W. and Thornton, I. 1994.  the contamination of agricultural land in the
                metalliferous province of southwest England: implications to livestock.  Agriculture Ecosystems
                & Environment; 48 (2): 125-137.

FL             Adachi, S., Kawai, H., Hosogai, Y., Takahashi, T., Yoshimura, H., Katayama, H., and Takemoto,
                K. 1980. Toxicity of hijiki (Hizikia fusiforme) extract containing unidentified arsenic compound.
                JFood Hyg Soc Jpn. 21 (6): (RECD. 1981). 425-434.

CP              Su, L. C., Csallany, A. S., Tangney, C. C., Driskell, J. A., Chow, C. K., Howell, G.,
                Hill, C. H., Prohaska, J. R., Ganther, H. E., Oh, S. H., Hoekstra, W. G., Burk, R. F., Nishiki, K.,
                Lawrence, R. A., Chance, B., Ullrey, D. E., Shelle, J. E., Brady, P. S., Miller, E. R., Ayaz, K. L.,
                Machlin, L. J., Gabriel, E., Horn, L. R., Spiegel, H. E., Nelson, J., Brin, M., Catignani, G. L.,
                Bieri, J. G., Thorp, S. L., Tolliver, T. J., Shih, J. C. H., Scott, M. L., Schloss, J.,  Corwin, L. M.,
                Ferretti, R. J., Morris, V. C., Levander, O. A., Scares, J. H. Jr., Swerdel, M., Sleet, R. B., Chou, A.
                C., Broun, G. O. Jr., Fitch, C. D., Heffron, J. J. A., Chan, A. C., Hegarty,  P. V. J., and Fisher, M.
                1977. federation of american societies for experimental biology; 61st annualmeeting, Chicago,
                Illinois april 1 -  8, 1977. selenium and vitamin e.  Federation Proceedings  36(3): 1094-1095,
                1167-1168.
FL
Fate
 Ado, V. A. and Horyachkina, L. A. modeling of chemical allergoses and their selective and
nonspecific inhibition.  Fiziol Zh (Kiev); 21 (4). 1975 481-485

Aguilar, M. V., Martinez-Para, M. C., and Gonzalez, M. J. 1997. effects of arsenic (v)-chromium
(iii) interaction on plasma glucose and cholesterol levels in growing rats.   Ann Nutr Metab.
Eco-SSLfor Arsenic
                                   33
March 2005

-------
CP
FL
An Prod
Org met
Gene
Dead
Abstract
No Oral
InVit
Diss
No Dose
HHE
FL
41(3): 189-95.

Aguilar, M. V., Martinez-Para, M. C., and Gonzalez, M. J. 1998. effect of as(v)-cr(iii) interaction
on body weight, plasma protein, urea, uric acid and creatinine levels in growing  rats.   Met. Ions
Biol. Med. Proc. Int. Symp., 5th :  280-284. Editor(s): Collery, Phillipe. Publisher: Libbey
Eurotext, Montrouge, Fr.

Aguilar, M. Victorina, Martinez-Para, M. Carmen, and Gonzalez, M. Jose.  1997. effects of
arsenic(v)-chromium(iii) interaction on plasma glucose and cholesterol levels in growing  rats.
Ann. Nutr. Metab.   41(3):  189-195.

Akhtar, M. H., Patterson, J. R., Salisbury, C. D. C., Ho, S. K., Jui, P. Y., and Hartin, K. E.  effects
of feeding 3 nitro-4-hydroxyphenylarsonic acid on growing-finishing pigs.. Canadian Journal of
Animal Science. 72 (2). 1992. 389-394.

Al-Timimi, A. A. and Sullivan, T. W.  1972.  safety and toxicity of dietary organic arsenicals
relative to performance of young turkeys part 1 arsanilic-acid and sodium arsanilate.   Poultry
Science.  51(1): 1972111-116.

Ali, A., Krone, P. H., Pearson, D. S., and Heikkila, J. J.  1996. evaluation of stress-inducible
hsp90 gene expression as a potential molecular biomarker in xenopus laevis.   Cell Stress &
Chaperones  1(1):  62-9.

Allen, G. T., Blackford, S. H., and Welsh, D.  1998. arsenic, mercury,  selenium, and
organochlorines and reproduction of interior least terns in the northern great plains, 1992-1994.
Colonial Waterbirds. 21(3): 356-366.

Alvarez-Barrera L(A), Corona-Martinez A(A), Rodriguez-Aguilera, E., Betancourt-Rule, M., and
Altamirano-Lozano, M. A(A).  2000. dna damage in leukocytes and testicular cells in male mice
after chronic or acute treatments with sodium arsenate.   Environmental and Molecular
Mutagenesis.   3 5 (Suppl. 31): 10.

Aly, S., Mousa, S., el-Kahky, M., Saleh, A., and el-Mofty, A. 1975. toxic deafness, i. histological
study of the effect of arsenic, salicylates and quinine, on the organ of corti of guinea pigs.
Journal of the Egyptian Medical Association.  58(3-4):  144-57.

Amacher, D. E. and Paillet, S. C. 1980. induction of trifluorothymidine-resistant mutants by
metal ions in 15178y/tk-plus/minus Cells.   MutatRes. 78 (3): 279-1

Amann, R. P.  reproductive toxicology of chemical mixtures.
Institutes Of Health
Crisp Data Base National
Amano, Ryohei, Oishi, Shigeo, Lit, B., Enomoto, Shuichi, and Ambe, Fumitoshi. biodistribution
of trace elements in normal, aluminum-overloaded and cadmium-overloaded  mice.  Ann. Clin.
Lab. Sci. (1996) 26(6): 531-541.

Ambrose, K. R., Butler, T. A., Callahan, A. P., and Ferren, L. A.  1987.  in vivo toxicity of arsenic
trioxide for human cells in diffusion chambers.   Govt Reports Announcements & Index (GRA&I)

Anca, Zoe, Gabor, Silvia, and Bordas, E.  arsenic and lead interaction with glucose metabolism
and acetylcholinesterase activity in the  rat  brain.    Stud. Cercet. Biochim. (1985)  28(1): 3-8.
Eco-SSLfor Arsenic
                                    34
                    March 2005

-------
Unrel           Andersen, F. A.  1996. amended final safety assessment of polyvinyl acetate.   Vol. 15, No. 2, Pp.
                166-176 J. Am. Coll. Toxicol.

Org met        Anderson Brian and Chamblee, T. N.  1998.  the effect of dietary 3-nitro-4-phenylarsonic acid on
                growth, processing yield fecal arsenic and litter arsenic in broiler chickens.  Poultry Science
                77(SUPPL. 1):  149.

FL             Angelow, L. Institut fuer Tierzucht Kostinbrod Bulgaria, Petrova, I., Yanchev, I., Anke, M,
                Groppel, B., Guertler, H., Gruen, M., Lombeck, L, and Schneider, H. J.  1992. the influence of a
                copper, zinc, arsenic, molybdenum and sulphur supply on the flora and fauna, 1: the influence on
                the trace element content of the flora.  die wirkung einer kupfer-, zink-, arsen-,
                molybdaen- und schwefelbelastung auf die flora und fauna, 1: der einfluss auf den
                spurenelementgehalt der flora, macro and trace elements.   mengen- und
                spurenelemente.   P. 395-402

Rev            Anke, M., Dorn, W., Gunstheimer, G., Arnhold, W., Glei, M., Anke, S., and Losch, E. 1998.
                effect of trace and ultratrace elements on the reproduction performanceof ruminants.   Veterinarni
                Medicina. 43(9):  272-282.

FL             Anke, M., Hennig, A., Gran, M., Partschefeld, M., Groppel, B., and Ludke, H. arsenic, a new
                essential trace element.   Archiv Fur Tierernahrung\ PY-1976\ VO- 26\  IS-10\ PG- P. 742-743\
                LA- Miniature Pigs Given As-Deficient and Normal Diets,  With As 50 or 350 Mu G/Kg Diet,
                Respectively, Indicate That the Fertility, Number of Live Births, Survival to Weaning and Total
                Weight of Offspring Were Adversely Affected in Both Species Deprived of As; Differences in the
                Total Weight of Young at Birth Were Highly Significant and There Was a Pronounced Retardation
                of Growth (24%) in the Lambs Born to Ewes Deprived of As During the  Sucking Period. Growth
                Rates After Weaning Were Adversely Affected in the Second Generation Only. During the
                Experiment There Was a 30% Adult Mortality in the Controls Which Increased to 71% in Those
                Deprived of As, Chiefly During the Period of Lactation, and Mostly Accompanied by Histological
                Evidence ofMyocardial Lesions.

Bio Ace         Anke, M., Hoffmann, G., Graen, M., Groppel, B., and Riedel, E. Karl-Marx-Universitaet Leipzig
                German D. R. Sektion Tierproduktion und Veterinaermedizin.  1982. absorption, distribution and
                excretion of arsenic-76 in hens and ruminants, the use of isotopes to detect moderate mineral
                imbalances in farm animals.  results of a co-ordinated research programme on the use of
                isotope techniques for detection of moderate mineral imbalances in farm animals organized by the
                joint fao/iaea division of isotope and radiation applications of atomic energy for food and
                agricultural development and presented at a research co-ordination meeting held in nicosia, Cyprus,
                6-10 October 1980.  P.  135-146

Diss            Anke, M., Krause, U., and Groppel, B.  1987. the effect of arsenic deficiency on growth,
                reproduction, lifeexpectancy and disease symptoms in animals.    533-550.

CP             Anke, M., Schmidt, A., Groppel, B., and Kronemann, H.  1983. further  evidence for the
                essentiality of arsenic.  Spurenelement-Symposium  4:  97-104.

CP             Anke, M., Schmidt, A., Kronemann, H., Krause, U., and Grahn, K.  1985. new data on the
                essentiality of arsenic.  Trace Elem. ManAnim. — TEMA  5 Proc. Int. Symp.,  5th :  Meeting Date
                1984, 151-4. Editor(s): Mills, C. F.; Bremner, L; Chesters, J. K. Publisher: CAB, FarnhamRoyal,
                Slough, UK.

No Oral        Anon,  controlling the cattle tick in new-south-wales.  AGR GAZNS W.  80  (6). 1969 356-368
Eco-SSL for Arsenic                               35                                       March 2005

-------
Reg
Unrel
No Oral
FL
Anon.  1935. report for 1990 of a study committee for testing the toxicity and other aspects of
dangerous exotic chemicals used in the ic industry and elsewhere,  japan industrial safety and
health association.
InVit



InVit


Acu


Drug


No Oral



Acu



Diss

Abstract


Mix


HHE
Anon.  1990
(GRA&I)
regional monitoring activities, may 1958.   Govt Reports Announcements & Index
Anon.  1996. thiouracil administration and thyroidectomy in experimental polyarthritis of rats.
Govt Reports Announcements & Index (GRA&I)

Antoniuk, M. V., Ivanova, I. L., and Khasina, E. I.  1996.  [the effect of the internal intake of
carbonate mineral waters on lipid and carbohydrate metabolism in the development of
experimental obesity].  vliianie vnutrennego priema uglekislykh mineral'nykh vod na
obmen lipidov i uglevodov pri razvitii eksperimental'nogo ozhireniia.  Voprosy Kurortologii,
Fizioterapii, i Lechebnoi Fizicheskoi Kultury;

Aoki, Y., Lipsky, M. M., and Fowler, B. A.  1990.  alteration in protein synthesis in primary
cultures of rat kidney proximal tubule epithelial cells by exposure to gallium, indium, and arsenite.
 Toxicology and Applied Pharmacology  106(3):  462-8.

Aoki, Yasunobu, Lipsky, Michael M., and Fowler, Bruce A. altered protein synthesis in rat
kidney cells exposed to semiconductor materials.  Appl. Organomet. Chem. (1994)  8(3):  253-8

Aposhian, H. V. 1981. Prevention and Treatment ofVesication and Poisoning Caused by
Arsenicals.   Annual Summary Rept. Feb 80-Jan 81

Aposhian, H. V. 1982. biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-
dimercaptosuccinic acid.  Advances in Enzyme Regulation  20:  301-19.

Aposhian, H. V., Tadlock, C. H., and Moon, T. E. 1981. protection of mice against lethal effects
of sodium arsenite--a quantitative comparison of a number of chelating agents.  Toxicology and
Applied Pharmacology 61(3): 385-92.

Aposhian, H. Vasken, Tadlock, Charles H., and Moon, Thomas E. protection of mice against
the  lethal effects of sodium arsenite - a quantitative comparison of a number of chelating agents.
 Toxicol. Appl. Pharmacol. (1981)  61(3):  385-92 CODEN: TXAPA9; ISSN: 0041-008X.

Arnold, R. L.  1971. effects of various levels of dietary selenium and arsenic on chickens .

Arnold, R. L. and Carlson, C. W.  life cycle studies with chickens using selenium and arsenic
Supplements.  Poultry Sci.  49 (5). 1970 1364-1365.

Arnold, R. L., Olson, O. E., and Carlson,  C. W. 1973. dietary selenium and arsenic additions and
their effects on tissue and egg selenium.  Poultry Sci. 52: 847-854.

 Atalla, L. T., Silva, C. M., and Lima, F. W.  1965.  activation analysis of arsenic in human hair--
some observations on the problem of external contamination.  An. Acad. Brasil. Cien.; 37(3/4):
433-441
Acute
Atkins, C. E. and Johnson, R. K.  1975.  clinical toxicities of cats.
652.
                                                Vet. Clin. N. Am.  5( 4): 623-
Eco-SSLfor Arsenic
                                   36
                                                              March 2005

-------
Surv           Augspurger, Tom, Franson, J. C., Converse, Kathryn A., Spitzer, Paul R., and Miller, Erica A.  an
                epizootic of common loons in coastal waters of north Carolina: concentrations of elemental
                contaminants and results of necropsies.  Environ. Toxicol. Chem. (1998)  17(2): 205-209.

Phys           Bacchi, C. J., Nathan, H. C., Livingston, T., Valladares, G., Saric, M, Sayer, P. D., Njogu, A. R.,
                and Clarkson, A. B. Jr.  1990. differential susceptibility to dl-alpha-difluoromethylornithine in
                clinical isolates of trypanosoma brucei rhodesiense.  Antimicrobial Agents and Chemotherapy
                34(6):  1183-8.

Drug           Bacchi, C. J., Nathan, H. C., Yarlett, N., Goldberg, B., McCann, P. P., Sjoerdsma, A., Saric, M.,
                and Clarkson, A. B. Jr.  1994. combination chemotherapy of drug-resistant trypanosoma brucei
                rhodesiense infections in mice using dl-alpha-difluoromethylornithine and standard trypanocides.
                Antimicrobial Agents and Chemotherapy  38(3): 563-9.

Unrel           Badakhsh, F F and Foster,  J W.  endotoxin-containing preparations of brucella abortus: biological
                studies.  Am J Vet Res.  Feb 1970 31(2): 365-369

Mix            Bai, K. M., Bhavnagary, H. M., and Majumder, S. K. enhancement of magnesium ammonium
                arsenate toxicity to rats.   Pestic. Sci. 5(5): 527-534; 1975.(13 References)

Rev            Baker, D. H. and Czarnecki-Maulden, G. L. 1987.  pharmacologic role of cysteine in ameliorating
                or exacerbating mineraltoxicities.   Journal of Nutrition  117(6):  1003-1010.

Drug           Baker, D. H., Robbins, K. R., and Willis, G. M. 1982. amino  acid utilization as influenced by
                antibacterial and anticoccidial drugs.  Federation Proceedings  41(11):  2824-7.

Surv           Baker, F. D.,  Tumasonis, C. F., Stone, W.  B., and Bush, B. 1976. levels of pcb and trace metals
                in waterfowl in new york state.  N. Y. Fish Game J. 23(1): 82-91.

CP             Balatincz, J.,  Ajtony, Z., and Tamasy, V.  1997. prenatal protein-energy malnutrition: its effects
                on mineral concentrations in  rats 'brain.  Mengen-Spurenelem. Arbeitstag., 17th : 525-535.
                Editor(s): Anke, Manfred. Publisher: VerlagHarald Schubert, Leipzig, Germany.

FL             Balatskii, K. P.  new aspects in the toxic effect of arsenic compounds and antidote therapy during
                poisoning of animals by them.   Visn. Sil's'Kogospod. Nauki (1978) (4): 58-62
FL

                (No.9):  84-86
Balatskii, K. P.  1976. arsenic poisoning in animals (experimental sodium arsenite or
calciumarsenate poisoning in cattle, treated with dimercaprol).  Veterinariya, Moscow, USSR
          -
Unrel           Baozhen, Wang. 1987. the  development  of ecological wastewater treatment and utilization
                systems (EWTUS) in China.  Water Sci. Technol. (1987)  19(1-2, Water Pollut. Res. Control,
                Rio de Janeiro, 1986, Pt. 1):  51-63 .

Unrel           Barbour, A. G. 1981.  vaginal isolates of staphylococcus aureus associated with toxic shock
                syndrome.  Infection and Immunity   33(2): 442-9.

In Vit            Barchowsky  Aaron(A), Klei Linda R, Dudek Edward J, Swartz Harold M, and James Philip E.
                1999.  stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial
                cells exposed to low levels of arsenite.  Free Radical Biology & Medicine  27(11-12):  1405-
                1412.
Eco-SSL for Arsenic                               37                                       March 2005

-------
Chem Meth
HHE
FL
InVit
Acute
Barnett, N. W., Chen, L. S., and Kirkbright, G. F.  1984. the rapid-determination of arsenic by
optical-emission spectroscopy using a microwave induced plasma source and a miniature hydride
generation device.   Spectrochimica Acta Part B-Atomic Spectroscopy  39(9-11): 1141-1147.

Baron, P. and Schweinsberg, F. 1989. a literature-review on concentrations of arsenic, cadmium,
lead and mercury in human-body fluids and tissues to localize normal levels and to detect
expositions .4. lead, summary of medium levels for As, Cd, Hg, Pb and references.  Zentralblatt
Fur Hygiene Und Umweltmedizin  188(3-4):  195-239.

Battistis, P. de and  Giordano, A. 1972. studies on arsenic in livers of slaughtered cows.
Zooprofilassi  27(1/2): 47-50.

Bauman, J. W., Liu, I, and Klaassen, C. D. 1993. production of metallothionein and heat-shock
proteins in response to metals.  Fundamental and Applied Toxicology  21(1): 15-22.

Baxley, M. N., Hood, R. D., Vedel, G. C., Harrison, W. P., and Szczech, G. M.  1981. prenatal
toxicity of orally administered sodium arenite in mice.  Bull.Environm.Contam.Toxicol.  26(6):
749-756.
Dup            Baxley M.N., Hood R.D., Vedel G.C., Harrison W.P., and Szczech G.M. 1981. prenatal toxicity
                of orally administered sodium arsenite in mice.  Bull. Environ. Contam. Toxicol Vol. 26, No. 6:
                pp. 749-756.

Abstract        Baxley, M. N., Vedel, G. C., Harrison, W. P., and Hood, R. D.  1980. effects of oral sodium
                arsenite on mouse development.  Teratology  21: A27.

Abstract        Beaudoin, A. R.  1973.  lack of teratogenic action of sodium arsenate in rats.  Teratology 7:724.

No Oral        Beaudoin, A. R.  1974.  teratogenicity of sodium arsenate in rats.  Teratology  10: 153-
                158,1974
FL
Acute
Beletskii, V. I. and Govyadin, V. G.  1979. tin arsenate poisoning in sheep.   Veterinariya,
Moscow, USSR (9): 43-45.

Bell, J.  1972.  the acute toxicity of four common poisons to the opossum, Trichosurus vulpecula.
New Zealand Vet. J. 20: 212-214.
InVit
InVit
FL
Belton, J. C., Benson, N. C., Hanna, M. L., and Taylor, R. T. growth inhibitory and cytotoxic
effects of 3 arsenic compounds on cultured Chinese hamster ovary cells.  J ENVIRON SCI
HEALTH PART A ENVIRON SCI ENG.  Journal of Environmental Science and Health Part A
Environmental Science and Engineering.  20(1). 1985. 37-72.

Belton, John C., Benson, Nancy C., Hanna, M. Leslie, and Taylor, Robert T. growth  inhibitory
and cytotoxic effects of three arsenic compounds on cultured Chinese  hamster  ovary cells.  J.
Environ. Sci. Health  Part A (1985):  A20(l), 37-72.

Bencko, V  1972.  tissue respiration of a mouse liver homogenate during poisoning by arsenic
administered with  drinking   water .  ii.  Zh. Gig. Epidemiol., Mikrobiol. Immunol.  16(1):
41-4.
FL
Bencko, V. and Benes, B. changes in blood glucose and the content of glucose and glycogen in
liver of mice  exposed to arsenic in  drinking   water.   Cesk. Hyg. (1978)  23(9): 377-82.
Eco-SSLfor Arsenic
                                   38
March 2005

-------
Fate            Bencko, V, Benes, B, and Cikrt, M. 1976. biotransformation of as (iii) to as (v) and arsenic
                tolerance .  Arch. Toxicol.  36(2): 159-162.

FL             Bencko, V., Benes, B., and Hajek, V.  the content of free sulfhydryl groups and the activity of
                glutathione reductase in the  liver of mice exposed to arsenic in drinking   water.   Cesk. Hyg.
                (1978)  23(5): 209-14.

No control      Bencko, V., Benes, B., Jechova, S., and Symon, K.  1980. the effect of a milk  diet  on the
                retention of arsenic-74 in mice.  J. Hyg. Epidemiol., Microbioi, Immunol.  24(4):  389-95.

No Oral        Bencko, V., Dvorak, V., and Symon, K. 1973. organ retention of parenterally administered
                arsenic labeled with arsenic-74 in mice preliminarily exposed to the element in drinking water
                arsenic tolerance.  J. Hyg. Epidemiol., Microbioi., Immunol.  17(2):  165-8.

No Oral        Bencko, V., Dvorak, V., and Symon, K. 1973. organ retention of parenterally administered
                arsenic (labelled with74as) in mice preliminarily exposed to the element in drinking water: astudy
                in arsenic tolerance.  Journal of Hygiene, Epidemiology, Microbiology and Immunology
                17(No.2): 165-168.

FL             Bencko, V., Dvorak, V., and Symon, K.  1973.  retention of parenterally administered arsenic-74-
                labeled arsenic in organs of mice having previously received arsenic in drinking   water  in
                relation to arsenic tolerance.  Zh. Gig. Epidemiol., Mikrobiol. Immunol.   17(2):  153-6.

FL             Bencko, V., Mokry, Z., and  Nemeckova, H.  1970.  metabolic oxygen consumption by  mouse
                liver homogenate during ingestion of arsenic.  Cesk. Hyg. (1970)  15(9/10): 305-8.

FL             Bencko, V., Nejedly, K., and Somora, J. 344. histological picture of certain organs following
                peroral administration of arsenic in hairless mice.   Cesk. Hyg.;  13(6)

FL             Bencko, V., Nejedly, K., Somora, J., and Symon, K. 1969.  analytical and  histological findings
                in hairless  mice  exposed to arsenic.   Cesk. Hyg.  (1969)  14(7-8): 266-71 CODEN: CEHYAN.

In Vitro        Bencko, V. and Nemeckova, H. 1971.  oxygen consumption by  mouse  live homogenate during
                drinking -  water arsenic exposure, i.  J. Hyg. Epidemiol., Microbioi., Immunol.   15(1):  104-
                10

InVit          Bencko, V. and Nemeckova, H. 1971.  oxygen consumption by mouse liver homogenate during
                drinking water arsenic exposure, i.  Journal of Hygiene, Epidemiology, Microbiology, and
                Immunology  15(1)

In Vitro        Bencko, V., Rossner, P., and Mokry, M. 1975.  dehydrogenase activity of liver parenchyma in
                mice exposed to arsenic in drinking water.  Journal of Hygiene, Epidemiology, Microbiology, and
                Immunology  19(1)

FL             Bencko, V. and Simane,  Z.  the effect of chronic intake of arsenic on the liver tissue respiration in
                mice.  Experientia (1968)  24(7): 706.

FL             Bencko, V. and Simane,  Z.  tissue respiration of liver parenchyma in hairless mice   exposed to
                arsenic.  Cesk. Hyg.  (1968) 13(5): 271-5.

Alt             Bencko, V. and Symon, K.  1969; (REF:27).  suitability of hairless  mice for experimental work
                and their sensitivity to arsenic.  J. Hyg. Epidemiol. Microbioi. Immunol. ; 13(1):  1-6
Eco-SSLfor Arsenic
39
March 2005

-------
Alt
Alt
FL
Gene
Mix
Mix
FL
Surv
CP
InVit
No Dose
Bencko, V. and Symon, K.  1953.  dynamics of arsenic cumulation in hairless mice after peroral
administration.   J. Hyg. Epidemiol. Microbiol. Immunol. 13(2): 248.

Bencko, V. and Symon, K.  1969.  suitability of hairless  mice  for experimental work and their
sensitivity of arsenic.   J. Hyg. Epidemiol., Microbiol., Immunol.   13(1):  1-6.

Benes, B. and Bencko, V. excretion of tri-and pentavalent arsenic in the urine of  mice  exposed
to a toxic concentration of trivalent arsenic in potable water (study of arsenic tolerance).   Cesk.
Hyg. (1976) 21(2): 56-9.

Benes, B. and Bencko, V.  1985.  incorporation of cl4-thymidine and cl4-uridine nucleosides into
nucleic acid molecules in the liver of  mice  exposed to  trivalent arsenic in  drinking  water.
J. Hyg. Epidemiol., Microbiol., Immunol.  29(4): 347-51.

Benjamin, S. A., Constan, A. A., Yang, R. S. H., Tessari, J. D., Baker, D. C., and Chubb, L.  1995.
lack of correlation between liver cell proliferation and preneoplastic foci in rats exposed to a
mixture of groundwater contaminants.   Toxicologic Pathology  23(6):  756.

Bennett, DG Jr and Schwartz, TE. 1971. cumulative toxicity of lead arsenate in phenothiazine
given to sheep.   Am J Vet Res. 32(5): 727-730.
Benzko, W. 1970. hygienic and lexicological problems of air pollution by arsenic.
Humboldt-Univ. Berlin Math.-Naturwiss. Reihe   19(5): 499-501.
 Wiss. Z.
Bergeland, M. E., Ruth, G. R., Stack, R. L., and Emerick, R. J. arsenic toxicosis in cattle
associated with soil and watercontamination from mining operations.

Bernardini, P., Boscolo, P., Carelli, G., lannaccone, A., and Sacchettoni-Logroscino, G.  1980.
effect of chronic arsenic exposure on the liver and on the peripheral nervous system.
Spurenelem.-Symp.: Arsen 3rd  : 199-204. Editor(s): Anke,  Manfred; Schneider, Hans-Joachim;
Brueckner, Chr. Publisher: Friedrich-Schiller- Univ. Jena Abt. Wiss. Publ., Jena, Ger. Dem. Rep.

Berry, J. P. and Galle, P.  1994.  selenium-arsenic interaction in renal cells: role of lysosomes.
electron microprobe study.  JSubmicrosc Cytol Pathol.  26(2): 203-10.

Berry, J. P., Zhang, L., and Galle, P. 1995. interaction of selenium with copper, silver, and gold
salts, electron microprobe study.   Journal ofSubmicroscopic Cytology and Pathology  27(1):
21-8.
Surv           Beyer, W. Nelson, Miller, Gary, and Simmers, John W.  trace elements in soil and biota in
                confined disposal facilities for dredged material.  Environ. Pollut. (1990)  65(1):  19-32

Unrel          Bezuidenhout, J. D. and Stutterheim, C. J.  1980.  a critical evaluation of the role played by the
                red-billed oxpeckerbuphagus erythrorhynchus in the biological control of ticks.  Onderstepoort
                Journal of Veterinary Research  47(2): 51-75.

FL             Bires, J.  1989. interactions between copper, iron, zinc, arsenic, cadmium, and lead in the liver of
                sheep after experimental poisoning with copper oxide.   Veterinarni Medicina.  34(11):  665-674.

Bio Ace          Bires, J. and Vrzgula, L.  1990. wool as an indicator of sheep exposure to copper iron zinc
                molybdenum arsenic lead cadmium and selenium from the industrial emission source.  Ekologia-
                CSSR. 9(4):  419-428.
Eco-SSLfor Arsenic
                                    40
March 2005

-------
FL
FL
FL
No Oral
Herp
No Oral
Bires, I, Vrzgula, L., and Mudron, P.  1990. the influence of experimental and spontaneous
copper intoxication on the contents of copper, iron, zinc, cadmium, arsenic and lead in the liver
and kidneys of ewes and their foetuses.   Zivocisna Vyroba - UVTIZ. 35(2):  159-168.

Bires, J. Ustav Experimentalnej Veterinarnej Mediciny Kosice Czechoslovakia, Vrzgula, L., and
Mudron, P. 1990. the influence of experimental and spontaneous copper intoxication on the
contents of copper, iron, zinc, cadmium, arsenic and lead in the liver and kidneys of ewes and their
foetuses.  vplyv experimentalnej a spontannej intoxikacie medou na obsah medi, zeleza,
zinku, kadmia, arzenu a olova v peceni a oblickach bahnic a ich plodov.   Zivocisna Vyroba -
UVTIZ. V.  35(2) P. 159-168

Bires, J. Vysoka Skola Veterinarska Kosice CSFR, Vrzgula, L., and Juhasova, Z.  1991.
distribution of harmful metals in ewes after experimental industrial contaminant intake. 
distribucia rizikovych kovov v organizme oviec po prijme priemyselnej emisie v experimente.
Veterinarni Medicina - UVTIZ.  V. 36(6) P. 361-371

Birge, W. J. and Just, J. J. sensitivity of vertebrate embryos to heavy metals as a criterion of
water quality.   NTISPB REPORT (PB-226 850):20 PP, 1973

Birge, W. J. and Just, J.  J. 1915.Sensitivity of Vertebrate Embryos to Heavy Metals As a Criterion
of Water Quality. Phase II. Bioassay Procedures Using Developmental Stages As Test Organisms.
 Research Kept.  RR-84; W75-06352; OWRT-B-039-KY(1)
Birge, W. J. and Roberts, O. W.  1976. toxicity of metals to chick embryos.
Contam. Toxicol.  16: 319-324.
       Bull. Environ.
No Oral
NoCOC
Mix
Birge, W. J., Westerman, A. G., and Roberts, O. W. lethal  and teratogenic effects of metallic
pollutants on vertebrate embryos.   Trace Contam. Environ.  Proc. Annu. NSF-RANN Trace
Contam. Conf., 2nd (1974):  Issue LBL-3217, 316-20 Publisher: NTIS, Springfield, Va.
Birnboim, H. C.  1985.  dna clastogenic activity of diethylstilbestrol.
 34(18):  3251-7.
Biochemical Pharmacology
 Bishop, Christine A., Boermans, Herman J., Ng, Peggy, Campbell, G. Douglas, and Struger,
John, health of tree swallows (tachycineta bicolor) nesting in pesticide-sprayed apple orchards in
Ontario, Canada, i. immunological parameters.  J. Toxicol. Environ. Health  Part A (1998): 55(8),
531-559.
Surv
Rev
No Oral
Bishop, Christine A., Van Der Kraak, Glen J., Ng, Peggy, Smits, Judit E. G., and Hontela, Alice.
health of tree swallows (tachycineta bicolor) nesting in pesticide-sprayed apple orchards in Ontario,
Canada, ii. sex and thyroid hormone concentrations and testes  development.  J. Toxicol. Environ.
Health  Part A (1998):  55(8), 561-581.

Biswas, N. M, Roychowdhury, G., and Sarkar, M. 1995. effect of sodium arsenite on
adrenocortical activities in male rats: dose- and duration-dependent responses.  Vol. 23, No. 3,
Pp. 153-154 Med. Sci. Res.

Biswas, MM, Roychowdhury, G, and Sarkar, M.  1995.  effect of sodium arsenite on
adrenocortical activities in male rats: dose- and duration-dependant responses.  Med. Sci. Res.
23: 153-154.
Acute
Biswas, S, Taluka, G, and Sharma, A.  1999.  prevention of cytotoxic effects of arsenic by short-
Eco-SSLfor Arsenic
                                   41
             March 2005

-------
                term dietary supplementation with selenium in mice in vivo.  Mutation Res. 441: 155-160.

Acute          Biswas, Sonali, Talukder, Geeta, and Sharma, Archana. 1999.  prevention of cytotoxic effects of
                arsenic by short-term  dietary  supplementation with selenium in  mice  in vivo.  Mutat. Res.
                (1999)  441(1):  155-160.

Orgmet        Bjoernstad, J., Opstvedt, I, andLunde, G.  1974. unidentified  growth  factors in fish meal.
                organic arsenic compounds in broiler diets.  Br. Poult. Sci. (1974). 15(5):  481-7.

Mix            Blakley, B.R. 1987. alterations in urethane-induced adenoma formation in  mice  exposed to
                selenium and arsenic.   Drug-Nutr. Interact. (1987) 5(2):  97-102.

Mix            Blakley, B. R. 1987. the effect of arsenic on urethane-induced adenoma formation in swiss mice.
                Can. J.  Vet. Res. (1987) 51(2): 240-3.

Orgmet        Blakley, B. R., Clark, E. G., andFairley, R.  1990.  roxarsone (3-nitro-4-hydroxyphenylarsonic
                acid) poisoning in pigs.  Canadian Veterinary Journal  31(5):  385-387.

Rev            Blus, L. J., Henny, C. J., and Grove, R. A.  1985. effects of pelletized anticoagulant rodenticides
                on California quail.  Journal Of Wildlife Diseases  21(4):  391-395.

Dead           Blus, L. J., Stroud, R. K., Reiswig, B., and Mceneaney, T.  1989. lead poisoning and other
                mortality factors in trumpeter swans.  Environ Toxicol Chem. 8(3):  p263-271.

Chem Meth     Boerma, D. O., Smit, E. P., and Roosnek, N. 1989. pixe trace-element determination and its
                accuracy in the analysis of bile.  Nucl. Instrum. Methods Phys. Res. Sect. B B36(l):  60-73.

FL             Bogos, V., Aureliu, C., Gheorghe, M, Chirila, C., and Blendea, G. 1987. increasing fecundity
                and natality in pigs by nutritional therapy.  Productia Animala,  Zootehnie Si Medicina Veterinara
                 37(8):  25-30.

Method         Bolton,  B. A. andHopke, P. K. 1975. the use of instrumental neutron activation analysis for the
                determination of arsenic concentrations in Poultry.  J Radio anal  Chem. Journal of
                Radioanalytical Chemistry. 25 (2): 299-302.

No Org         Boon, D. Y.  1989. potential selenium problems in great plains soils.  SSSA (Soil Sci SocAm)
                Spec Publ Ser; 23.: 107-122.

FL             Boscolo, P., Carmignani, M., Porcelli, G., L'abbate, N., and Ripanti, G.  1980.  cardiovascular
                function and urinary kallikrein excretion in rats chronically exposed to mercury, arsenic, lead,
                cadmium or cadmium and lead.  Acta MedRom; 18 (2). 1980 (RECD. 1981). 211-217.

FL             Boscolo, Paolo, Carmignani, Marco, Sacchettoni-Logroscino, Gabriella, Carelli, Giovanni, and
                Bernardini, Pierluigi.  1982. chronic exposure of  rats  to arsenic: morphological and functional
                comparisons.  G. /to/. Med. Lav. (1982)   4(4-5):  169-74.

No Oral        Bosque, M. A., Domingo, J. L., Llobet, J. M., and Corbella, J.  1991.  effects of meso-2,3-
                dimercaptosuccinic acid (DMSA) on the teratogenicity of sodium arsenate in mice.  Bull.
                Environ. Contain. Toxicol.   47(5): 682-8.

Drug           Bosque, M. A., Paternain, J. L., Domingo, J. L., Llobet, J. M., and Corbella, J.  1990. prevention
                by meso-2,3-dimercaptosuccinic acid (DMSA) of sodium arsenite-induced embryotoxic and
Eco-SSLfor Arsenic
42
March 2005

-------
Acute
No Oral
Surv
NoOrg
Unrel
QAC
Org met
teratogenic effects in mice.   Trace Elem Med. 7(2):  69-70.

Bosque, M. A., Paternain, J. L., Domingo, J. L., Llobet, J. M, and Corbella, J.  1990.  prevention
by meso-2,3-dimercaptosuccinic acid (dmsa) of sodium arsenite-induced embryotoxic effects in
mice.  Met. lonsBiol. Med. Proc. Int. Symp.,  1st  : 345-7.  Editor(s): Collery, Philippe. Publisher:
Libbey, Paris, Fr.

Bosque, M. A., Piera, V., Domingo, J. L., and Corbella, J. 1991. meso-2,3-dimercaptosuccinic
acid (dmsa) alleviation of arsenite-induced embryofetotoxicity in mice: effectiveness with time.
Toxicologist.  Feb;ll(l): 295.

Bourne, W. R. P.  1976. the mass mortality of common murres in the irish sea in 1969.   J.Wildl.
Manage.  40(4): 789-792 1976 (35 References)

Boyer, Kenneth W. and Capar, Stephen G.  1977.  fortification variability in  rat  diets fortified
with arsenic, cadmium, and lead .  J. Toxicol. Environ. Health  3(4): 745-53 .

Briones, Annabelle V., Ambal, Wilhelmina O., Monroyo, Evangelina C., Bonifacio, Teresita S.,
and Sison, Fe M. 1997.  seaweed tablet: a natural source of iodine.  Philipp. J. Sci. (1997)
126(3): 221-232

Brostrom, C. O., Prostko, C. R., Kaufman, R.  J., and Brostrom, M. A. 1996.  inhibition of
translational initiation by activators of the glucose-regulated stress protein and heat shock protein
stress response systems, role of the interferon-inducible double-stranded rna-activated eukaryotic
initiation factor 2alphakinase.  Journal of Biological Chemistry  271(40):  24995-5002.

Brown, T. P., Larsen, C. T., Boyd, D. L., and Allen, B. M. 1991. ulcerative cholecystitis
produced by 3 nitro-4-hydroxyphenylarsonic acid toxicosis in turkey Poults.  Avian Dis; 35 (1).
1991. 241-243.
Abstract        Brumm, M. C., Sutton, A. L., and Mayrose, V. B.  dietary arsenic effects on stored swine waste.
                Journal of Animal Science. 42(5). 1976 1340

Org met        Brumm, M. C., Sutton, A. L., Mayrose, V. B., and Krider, J. L.  1979.  effect of dietary arsonic
                acids on fresh swine waste composition andanaerobic decomposition.  Journal of Animal Science
                48(6):  1305-1311.

Org met        Brumm, M. C., Sutton, A. L., Mayrose, V. B., Nye, J. C., and Jones, H. W.  1977. effect of
                arsanilic-acid in swine diets on fresh waste production composition and anaerobic decomposition.
                Journal of Animal Science. 44 (4):  521-531.

Rev            Buck, WB. toxicity of inorganic aliphatic organic arsenicals. in Oehme, FW (Ed)  Toxicity of
                Heavy Metals in the Environment.:  357-374.

No Dose        Bucy, LL, Garrigus, US, Forbes, RM, Norton, HW, and James, MF. 1954. arsenical supplements
                in lamb fattening rations.  J.Anim.Sci.   13: 668.

n = 1            Bucy, L.L., Garrigus, U.S., Forbes, R.M,  Norton, HW, and Moore, W.W. 1955. toxicity of some
                arsenicals to growing-fattening lambs.  J.Anim.Sci.  14: 435.

Surv            Bukovjan, K., Wittlingerova, Z., and Cerna, E. 1997. chemical elements in tissues and
                histological changes in tissues ofhares (1.  europaeus pall.).  Scientia Agriculturae Bohemica.
Eco-SSLfor Arsenic
                                   43
March 2005

-------
                28(3):  215-226.

Bio Ace         Burger, J. and Gochfeld, M.  1997. age differences in metals in the blood of herring gull (Lams
                argentatus) and franklin's (Laruspipixcan) gulls.  Arch Environ Contamin Toxicol.  33(4): 436-
                440.

Surv           Burger, J. and Gochfeld, M.  1997. age differences in metals in the blood of herring (Lams
                argentatus) and franklin's (Larus pipixcan) gulls.  Archives of Environmental Contamination and
                Toxicology  33(4): 436-440.

Bio Ace         Burger, J., Woolfenden, G. E., and Gochfeld, M. 1999. metal concentrations in the eggs of
                endangered florida scrub-jays from central florida.  Archives of Environmental Contamination
                and Toxicology  37(3): 385-388.

Abstract        Burk, D.  T.  1976. arsenic induced renal agenesis in the wistar rat.  Teratology.  13 (2). 197619a

No Oral        Burk, Dorothy and Beaudoin, 1977. Allan R.  arsenate-induced renal agenesis in  rats.
                Teratology (1977)  16(3): 247-59.

Diss            Burk, Dorothy Thamah.  1976.  inorganic arsenic: placenta! transfer and effect on embryogenesis
                of the urogenital system of the  rat.  Avail.: Xerox Univ. Microfilms. Ann Arbor, Mich., Order
                No. 77-7884 From: Diss. Abstr. Int. B 1977, 37.  10. 4805-6.  89 pp.

Drug            Burns, Leigh Ann, McCay, J. Ann, Brown, Ronnetta, and Munson, Albert E.  1993.  arsenic in
                the  sera of gallium arsenide-exposed   mice  inhibits bacterial  growth  and increases host
                resistance.   J. Pharmacol. Exp. Ther.  265(2):  795-800.

Surv           Butler, D. L., Krueger, R. P., Osmundson, B. C., and Thompson, A. J. 1993.Reconnaissance
                Investigation of Water Quality, Bottom Sediment, and Biota Associated With Irrigation Drainage
                in the Pine River Project Area, Southern Ute Indian Reservation, Southwestern Colorado and
                Northwestern New Mexico, 1988-89 :  105 pp.

Bio Ace         Cahill, T. M, Anderson, D.  W., Elbert, R. A., Perley, B. P., and Johnson, D. R. 1998. elemental
                profiles in feather samples from a mercury-contaminated lake in central California.  Arch.
                Environ.  Contam. Toxicol.  35(1): 75-81 .

Abstract        Calvert, CC and Smith, LW. 1972. arsenic in milk and blood of cows fed organic arsenic
                compounds.   J. Dairy Sci.  55:  706.

Org met        Calvert, CC and Smith, LW. 1981. arsenic in tissues of sheep and milk of dairy cows fed
                arsanilic  acidand3-nitro-4-hydroxyphenylarsonic acid.  J.Anim.Sci. 51(2):  414-421.

No Control     Calvery,  H. O. E. P. Laug and H. J. Morris.  1938. the chronic effects on dogs of feeding diets
                containing lead acetate, lead arsenate and arsenic trioxide in varying concentrations.   J.
                Pharmacol. Exp. Ther. 64:  364-387.

No Oral        Cannon,  J. R., Saunders, J. B., and Toia, R. F. isolation and preliminary lexicological evaluation
                of arsenobetaine: the water-soluble arsenical constituent from the hepatopancreas of the western
                rock lobster (Panulims cygnus).  Sci Total Environ; 31 (2). 1983. 181-186.

No Dose        Cannon,  J. R., Saunders, J. B., and Toia, R. F.  1983. isolation and preliminary toxicological
                evaluation of arsenobetaine  - the water-soluble arsenical constituent from the hepatopancreas of
Eco-SSLfor Arsenic
44
March 2005

-------
                the western rock lobster.  Science of the Total Environment  31(2):  181-5.

In Vit          Cantoni, Orazio, Hussain, Saber, Guidarelli, Andrea, and Cattabeni, Flaminio. 1994. cross-
                resistance to heavy metals in hydrogen peroxide-resistant cho cell variants.  Mutat. Res.   324(1-
                2): 1-6.

Mix            Capar, Stephen G. and Boyer, Kenneth W. 1977. fortification variability in rat diet fortified with
                arsenic, cadmium, and lead.  Journal of Toxicology and Environmental Health.  3(4): 745.

CP             Carmignani, M, Carelli, G., Sacchettoni-Logroscino, G., Gioia, A., and Boscolo, P. 1983.
                chronic exposure of  rats to sodium arsenite or arsenate: cardiovascular function and tissue metal
                levels.  Spurenelem.-Symp. 4th :  119-26. Editor(s): Anke, Manfred. Publisher: Friedrich-
                Schiller-Univ., Jena, Ger. Dem. Rep.

No Oral        Carpenter, S. J.  1987. development analysis of cephalic axial dysraphic disorders in arsenic-
                treated hamster Embryos.  Anat Embryol.  176(3):  345-366.

No Oral        Carpenter, S. J.  1987. developmental analysis of cephalic axial dysraphic disorders in arsenic-
                treated hamster embryos. Anatomy and Embryology  176(3):  345-65.

Abstract        Carpenter, S. J. and Perm, V. H. 1977. early stages in development of exencephaly in arsenic-
                treated hamster embryos.  Teratology  15: A23.

Drug           Castejon, M., Tagliaferro, M., and Cedeno, G.  1987.  use of anabolics in the finishing of cattle.
                informe anual, institute de produccion animal,universidad central de Venezuela.
                 155.

Alt             Chaineau, E., Binet, S., Pol, D., Chatellier, G., and Meininger, V.  embryotoxic effects of sodium
                arsenite and sodium arsenate on mouse embryos in culture.  Teratology. 41 (1). 1990.  105-112.

Mix            Chapin, Robert E., Phelps, Jerry L., Schwetz, Bernard A., and Yang, Raymond S. H. toxicology
                studies of a chemical mixture of 25 groundwater contaminants, iii.  male reproduction  study in
                b6c3fl  mice .   Fundam. Appl. Toxicol. (1989)  13(3): 388-98 .

Prim           Charbonneau, S. M., Spencer, K.,Bryce, F., and et, a. 1. 1978. arsenic excretion by monkeys
                dosed with arsenic-dosed fish or with inorganic Arsenic.  Bulletin of Environmental
                Contamination and Toxicology 20(4): 470-477.

Org met        Chen, H, Yoshida, K, Wanibuchi, H, Fukushima, S, Inoue, Y, and Endo, G.  1996.  methylation
                and demethylation of dimethylarsinic acid in rats following chronic oral expossure.   Appl.
                Organometallic Chem.  10:  741-745.

No Org         Chen, M, Ma, LQ, and Harris, WG. 1999. baseline concentrations of 15 trace elements in florida
                surface soils.   J. Environ. Quality. 28: 1173-1181.

In Vit          Chen, M. L., King, R. S., and Armbrecht, H. J. 1990.  sodium-dependent phosphate transport in
                primary cultures of renal tubule cells from young and adult rats.  Journal of Cellular Physiology
                143(3): 488-93.

FL             Choe, R. S., Boo, M.  J., and Kim, H. H.  1990. studies on the properties of intracellular arsenic
                binding substances in the rat liver.  Korean J Zoo/.  33(4): 476-492.
Eco-SSL for Arsenic                               45                                       March 2005

-------
Unrel           Choi Wahn Soo(A), Chung Kae Jong, Chang Man Sik, Chun Kae Kwang, Lee Hyang Woo, and
                Hong Sung Youl. 1993.  a turbidimetric determination of protein by trichloroacetic acid.
                Archives of Pharmacal Research (Seoul)  16(1):  57-61.

No Oral        Choudhury, A. R., Das, T., and Sharma, A.  1997. mustard oil and garlic extract as inhibitors of
                sodium arsenite-induced  chromosomal breaks in vivo.  Cancer Letters  121(1): 45-52.

No Oral        Choudhury Arati Roy (A), Das Tandra, Sharma Archana, and Talukder Geeta.  1997. inhibition of
                clastogenic effects of arsenic through continued oral administration of garlic extract in mice in
                vivo.   Mutation Research  392(3): 237-242.

Diss            Cibulka, I, Slamova, A., Szakova, I, Miholova, D., Mader, P., Svatos, Z.,  Anke, M,
                Meissner, D., and Mills,  C. F.  1993. cadmium status in rats contaminated with cadmium and
                arsenic from theirdiet.    579-580.

Mix            Cikrt, M., Mravcova, A., Malatova, I., andBencko, V.  1988.  distribution and excretion of 74as
                and 75se in rats after their simultaneous administration, the effect of arsenic, selenium  and
                combined pretreatment.  Journal of Hygiene, Epidemiology, Microbiology,  and Immunology
                32(1)

Herp           Clark, D. R. Jr., Cantu, R., Cowman, D. F., and Maxson, D. J.  1998. uptake of arsenic and metals
                by tadpoles at an historically contaminated texas site.   Ecotoxicology. 7(2): 61-67.

Rev            Clarkson, T. W.  1977. factors involved in heavy metal Poisoning.  FedProc. 36(5):  1634-
                1639.

Rev            Clements, HF and Munson, J.  1947. arsenic studies in soil and in culture solution.  Pacific Sci.
                1: 151-171.

FL             Cobo, J. M., Gonzalez, M. J., Perez Piqueras, J. L., Aguilar, M. V., and Martinez Para, M. C.
                1990. effect of chromium over insulin levels and its interaction with the arsenic of the diet.
                Anales De Bromatologia 42(1):  133-138.

FL             Cobo, J. M., Gonzalez, M. J., Perez Piqueras, J. L., Aguilar, M. V., and Martinez Para, M. C.
                Alcala de Henares Univ.  Madrid Spain Facultad de Farmacia. 1990. effect of chromium over
                insulin levels and its interaction with the arsenic of the diet.  efecto del cromo sobre los
                niveles de insulina: interaccion con el arsenico de la dieta.   Anales De Bromatologia.  V. 42(1) P.
                133-138

Diss             Cobo, J. M.,  Valdez, J. G., and Gurley, L. R.  1994. Inhibition ofMitotic-Specific Histone
                Phophorylation by Sodium Arsenile. LA-UR-94-3210; CONF-9409234-1

Acu            Colomina, M. T., Albina, M. L., Domingo, J. L., and Corbella, J.  influence of maternal restraint
                stress on arsenic-induced pre- and postnatal alterations in mice.  Psychobiology 1996
                Sep;24(3):227-34

Acute           Colomina, MT, Albina, ML, Domingo, JL, and Corbella, J. 1997.  influence of maternal sress on
                the effects of prenatal exposure to methylmercury and arsenic on postnatal development and
                behavior in mice: a preliminary evaluation.  Physiol. Behav.  61(3): 455-459.

No Dose        Confer, Anthony W., Ward, Billy C., and Hines, Fred A. arsanilic acid toxicity in  rabbits.  Lab.
                Anim. Sci.  (1980) 30(2,  Pt. 1): 234-6
Eco-SSL for Arsenic                               46                                       March 2005

-------
Org met        Confer, AW, Ward, BC, and Hines, FA.  1980.  arsanilic acid toxicity in rabbits.  Lab. Anim. Sci.
                30(2 (part 1)):  234-236.

Abstract        Conner, EA, Yamauchi, H, and Fowler, BA.  1992. effects of indium and arsenide on heme
                biosynthetic pathway.   The Toxicologist.  12(1): 360.

No Oral        Conner, EA, Yamauchi, H, and Fowler, B A.  1995. alterations in the heme biosynthetic pathway
                from the iii-v semiconductor metal, indium arsenide (inas).   Chemico Biol. Interact.  96(3): 273-
                285.
Mix
Mix
Mix
Mix
FL
Unrel
Unrel
Chem Meth
Unrel
Constan, A. A., Benjamin, S. A., Tessari, J. D., Baker, D. C., and Yang, R. S. 1996. 1995 STP
young investigator award recipient, increased rate of apoptosis correlates with hepatocellular
proliferation in fischer-344 rats following long-term exposure to a mixture of groundwater
contaminants.   Toxicologic Pathology  24(3): 315-22.

Constan, A. A., Yang, R. S., Baker, D. C., and Benjamin, S. A. 1995. a unique pattern of
hepatocyte proliferation in f344 rats following long-term exposures to low levels of a chemical
mixture of groundwater contaminants.   Carcinogenesis  16(2): 303-10.

 Constan, A. A(A), Benjamin, S. A., Yang, R. S. H., Tessari, J. D., and Baker, D. C.  1995.
increased rate of apoptosis correlates with hepatocellular proliferation in fischer-344 rats following
long-term, low-level exposure to a mixture of groundwater contaminants.   Toxicologic Pathology
23(6):  755-756.

Constan Alexander A(A), Benjamin Stephen A, Tessari John D, Baker Dalec., and Yang
Raymond S H. 1996. increased rate  of apoptosis correlates with hepatocellular proliferation in
fischer-344 rats following long-term exposure to a mixture of groundwater contaminants.
Toxicologic Pathology  24(3): 315-322.

Costa, Maria R. M, Da Fonseca, Maria I. C., and Do Paco, Natalia M. 1970. arsenic content of
meat and viscera in  chickens.   Rev. Port. Farm.  20(1): 1-7..

Crans Debbie C(A), Simone Carmen M, Holz Richard C, and Que Lawrence Jr. 1992.  interaction
of porcine uterine  fluid purple acid phosphatase with vanadate and vanadyl cation.   Biochemistry
31(47):  11731-11739.

Creffield, J. W. and Tarn Mun Kwong. 1979. laboratory assessments of the efficacy of cca and
pep-treated dyeracostulata (jelutong)  against two species of australian termites.  Malaysian
Forester.  42(3):  230-239.

Croteau, L. G., Akhtar, M. H., Belanger, J. M. R., and Pare, J. R. J. 1994. high performance
liquid chromatography determination followingmicrowave assisted extraction of 3-nitro-4-
hydroxyphenylarsonic acidfrom swine liver, kidney and muscle.  Journal of Liquid
Chromatography  17(13):  2971-2981.

Crowder, M. W., Vincent, J. B., and Averill, B. A(A).  1992.  electron paramagnetic resonance
studies on the high-salt form of bovine spleen purple acid phosphatase.  Biochemistry  31 (40):
9603-9608.
Surv
Custer, T. W. and Mitchell, C. A. 1991. contaminant exposure of willets feeding in agricultural
drainages of the lower rio grande valley of south texas (Usa).   Environ Monit Assess.  16(2):
189-200.
Eco-SSLfor Arsenic
                                   47
March 2005

-------
Surv           Custer, T. W. and Mitchell, C. A. 1993. trace elements and organochlorines in the shoalgrass
                community of the lower lagunamadre, texas.  Environ Monit Assess  25(3): 235-246.

Surv           Custer, Thomas W. and Hohman, William L. trace elements in canvasbacks (Aythya valisinerid)
                wintering in louisiana, usa, 1987-1988.  Environ. Pollut. (1994)  84(3): 253-9.

Surv           Custer, Thomas W. and Mitchell, Christine A. 1991.  contaminant exposure of willets feeding in
                agricultural drainages of the lower rio grande valley of south Texas.   Environ. Monit. Assess.
                (1991)  16(2):  189-200.

Org met        Czarnecki, G. L. and Baker, D. H. 1985.  reduction of liver copper concentration by the organic
                arsenical, 3 -nitro-4-hydroxyphenylarsonic acid.   Journal of Animal Science  60(2):  440-50.

Org met        Czarnecki, G. L., Baker, D. H., and Garst, J. E.  1984.  arsenic-sulfur amino acid interactions in the
                chick.   J.Anim.Sci. (1984). 59(6):  1573-81.

Bio Ace         Daghir, N. J. and Hariri, N. N. 1977.  determination of total arsenic residues in chicken Eggs.  J
                Agric Food Chem. 25 (5).  1977 1009-1010.

Chem Meth     Dal Lago, A. and Lucke, S. 1973. a method of fixing rat testis for light and electron microscopy.
                Stain Technology 48(6):  289-95.

Mix            Dam Trung Bao and Nguyen Quang Thuong.  1985. effect of arsenic and selenium on the
                nonprotein sulfhydryl and disulfide content of the liver and the brain of mice.  Rev. Pharm.
                (1985) 92-102

Surv           Danielsson, B. R., Dencker, L., Lindgren, A., andTjalve, H. 1984. accumulation of toxic metals
                in male reproduction organs.  Arch Toxicol Suppl. 7:  177-80.

Plant           Darmody, Robert G., Green, William P., and Dreher, Gary B. 1998. coal slurry solids/coal
                fluidized bed combustion byproduct mixtures as plant growth media.   Int. J. Surf. Min. (Reclam.
                Environ.): 12(3), 111-115 .

FL             Das, P. M., Sadana, J. R., Gupta, R. K. P., and Kumar, K.  1989.  experimental selenium toxicity
                in guinea pigs: biochemical studies.  Annals Of Nutrition And Metabolism.  33(1): 57-63.

FL             Das, P. M., Sadana, J. R., Gupta, R. K. Paul, and Gupta, R. P. experimental selenium toxicity in
                guinea   pigs  : hematological studies.  Ann. Nutr. Metab. (1989) 33(6):  347-53.

CP             Das, T., Roychoudhury, A., and Sharma, A. 1997. bio-anticlastogenic effects of mustard oil and
                garlic in the first-generation offsprings of sodium arsenite treated mice.   Mutation Research
                379(1 SUPPL. 1): S89.

No Oral        Das, T., Roychoudhury, A., Sharma, A., and Talukder, G.  1993.  modification of clastogenicity
                of three known clastogens by garlic extract in mice in vivo.  Environmental and Molecular
                Mutagenesis 21(4): 383-8.

Gene           Datta, Supriti, Talukder, Geeta, and Sharma, Archana.  1986.  cytotoxic effects of arsenic in
                dietary  oil primed  rats.   Sci. Cult. (1986)  52(6):   196-8.

Bio Ace         Dauwe, T., Bervoets, L., Blust, R., Pinxten, R., and Eens, M.  1999. are eggshells and egg
                contents of great and blue tits suitable as indicators of heavy metal Pollution?  Belgian Journal of
Eco-SSLfor Arsenic
48
March 2005

-------
                Zoology; 129 (2). 1999. 439-447.

CP             Davies, N. T. 1981. an appraisal of the newer trace elements.  Philosophical Transactions of the
                Royal Society of London. Series B:

Unrel           Davis, S. D., Gibbons, D. F., Martin, R. L., Levitt, S. R., Smith, I, and Harrington, R. V.
                biocompatibility of ceramic implants in soft tissue.  JBiomedMater Res.  6 (5): 1972 425-449.

No Oral        DeKimpe, I, Cornelis, R., Wittevrongel, L., and Vanholder, R.  1999. dose dependent changes in
                74as-arsenate metabolism of flemish giant rabbits.   Journal of Trace Elements in Medicine and
                Biology  12(4): 193-200.

Abstract        DeRuiterN, Mailaender, V., andKappus, H. 1984.  effect of heavy metals on cellular growth
                metabolism and integrity of cultured Chinese hamster kidney cells.  3rd International Workshop
                on Tissue Culture Application in Toxicology

Dup            Debidas Ghosh, Sandip Cattopadhyay, and Jogen Debnath.  1999.  effect of sodium arsenite on
                adrenocortical activity in immature femalerats: evidence of dose dependent response.   Journal of
                Environmental Sciences  11(4):  419-422.

Carcin          Deknudt, G., Leonard, A., Arany, I, Jenar-du Buisson G, and Delavignette, E.  1984.  in-vivo
                studies on the mutagenicity of arsenic.   14th Annual Meeting of the European Environmental
                Mutagen Society

In Vitro        Deknudt, G., Leonard, A., Arany, I, Jenar-Du Buisson, G., and Delavignette, E. 1986.  in vivo
                studies in male mice on the mutagenic effects of inorganic arsenic.  Mutagenesis  1(1):  33-4.

In Vit           Delnomdedieu, Marielle, Basti, Mufeed M, Styblo, Miroslav, Otvos, James D., and Thomas,
                David J.  1994.  complexation of arsenic species in  rabbit  erythrocytes.  Chem.  Res. Toxicol.
                (1994)  7(5): 621-7.

CP             Den Tonkelaar E M, Kroes, R., and Van Logten M J. comparative toxicity studies of lead arsenate
                and lead acetate in Rats.   Int Union Pharmacol. Proceedings of the International Congress of
                Pharmacology, 6th. Abstract. Helsinki, Finland, 1975. 632p. Illus. Pergamon Press: Oxford, Engl.;
                New York, N.y., Usa. Isbn 0-08-021308-1. 1977 33

Bio Ace         Denneman, W. D. and Douben, P. E. T.  1993.  trace metals in primary feathers of the barn owl
                (Tyto alba guttatus) in the netherlands.   Environ. Pollut.   82(3):  301-10  .

Abstract        DeSesso, JM, Jacobson, CF, Scialli, AR, Farr, CH, and Holson, JF. 1998.  inorganic arsenic is not
                likely to be a developmental toxicant at environmentally relevant exposures.   Toxicology.
                57(4/5):  216.

Aquatic         Desgranges, J. L., Rodrigue, I, and Champoux, L. 1993.  outline of an exotoxicological
                surveillance network for fauna of the saint lawrence the role of the Canadian wildlife service.
                Twentieth Annual Aquatic Toxicity Workshop

Dead           DeSloovere, J., Debackere, M., and Hoorens, J.  1971. poisoning of domestic animals.   Vlaams
                Diergeneesk. Tijdschr. 40(1): 8-29; 1971(REF:18)

FL             Dinu, I., Boghianu, L., Botescu, E., and Sporn, A. 1972.  effect of some metals on carbohydrate
                metabolism.  Igiena.  21(8): 469-476.
Eco-SSLfor Arsenic
49
March 2005

-------
CP
Unrel
Surv
InVit
No Dose
Unrel
InVit
Diplock, A. T. and Mehlert, A. 1980. the effect of arsenic and vitamin e on the uptake and
distribution in the rat  of selenium-75-labeled sodium selenite.  Spurenelem.-Symp.: Arsen 3rd :
75-81. Editor(s): Anke, Manfred; Schneider, Hans-Joachim; Brueckner, Chr. Publisher: Friedrich-
Schiller- Univ. Jena Abt. Wiss. Publ., Jena, Ger. Dem. Rep.

Disa, S., Manilla, A. C., and Scher, C. D. 1989. purification and characterization of a platelet-
derived growth factor and heavy metal-modulated nuclear protein.  Journal of Biological
Chemistry  264(27): 15993-9.

Divers, T. J., Crowell, W. A., Duncan, J. R., and Whitlock, R. H.  1982. acute renal disorders in
cattle: a retrospective study of 22 cases.   Journal of the American Veterinary Medical Association
  181(7): 694-699.

Dix, D. J. and Hunter, E. S. function of hsp70s during embryogenesis.  1996. Dev Biol 1996
Mayl;175(2):394.

Dogan, A.  1996.  amounts of arsenic in goose embryos that died during incubation.  Etlik
VeterinerMikrobiyoloji Dergisi 8(3):  84-89.

Dolan, T. T. 1999.  dogmas and misunderstandings in east coast fever.   Tropical Medicine and
International Health 4(9):  A3-A11.

Dolzhanskaya, Natalia, Goncharova, Ekaterina, and Rossman, Toby G.  1998. isolation and
properties of lead-resistant variants of  rat  glioma cells.  Biol. Trace Elem. Res. (1998)   65(1):
31-43 .
No Oral        Domingo, J. L., Bosque, M. A., and Piera, V.  1991. meso-2,3-dimercaptosuccinic acid and
                prevention of arsenite embryotoxicity and teratogenicity in the  mouse.  Fundam. Appl. Toxicol.
                (1991)  17(2):  314-20.

No Oral        Domingo, J. L., Gomez, M., Sanchez, D. J., and Llobet, J. M. 1995. effects of monoisoamyl
                meso-2,3-dimercaptosuccinate on arsenite-induced maternal and developmental toxicity in mice.
                Vol. 89, No.  3, Pp. 389-400 Res. Commun. Mol. Pathol. Pharmacol.

Abstract        Domingo, J. L., Llobet, J. M., Ortega, A., Paternain, J. L., and Corbella, J.  1990.  effects of meso-
                2,3-dimercaptosuccinic acid (dmsa) in the pregnant rat: teratogenicity and tissue trace elements.
                Teratology.  42(2):   23A.

No COC        Domingo, J. L., Ortega, A., Paternain, J. L., Llobet, J. M., and Corbella, J.  1990.  oral meso-2,3-
                dimercaptosuccinic acid in pregnant sprague-dawley rats: teratogenicity and alterations in mineral
                metabolism, i. teratological evaluation.  Journal of Toxicology and Environmental Health  30(3):
                181-90.

Abstract        Domingo, JL, Llobet, JM, Ortega, A, Paternain, JL, and Corbella, J. 1990. effects of meso-2,3-
                dimercaptosuccinic acid (dmas) in the pregnant rat: teratogenicity and tissue trace elements.
                Teratology.  42(2): 23A.

No COC        Domingo, JL, Ortega, A, Paternain, JL, and Llobet, JM. 1990.  oral meso-2,3-dimercaptosuccinic
                acid in pregnant sprague-dawley rats: teretogenaity and alterations in mineral metabolism,  i.
                teratological evaluation.   J. Toxicol. Environ. Health. 30(3):  181-190.

No COC        Domingo Jose L.  1995. prevention by chelating agents of metal-induced developmental toxicity.
Eco-SSLfor Arsenic
                                   50
March 2005

-------
                Reproductive Toxicology  9(2):  105-113.

No Oral        Domingo, Jose O., Bosque, M. Angeles, Llobet, Juan M, and Corbella, Jacinto.  1992,
                amelioration by bal (2,3-dimercapto-l-propanol) and dmps (sodium 2,3-dimercapto-l-
                propanesulfonic acid) of arsenite  developmental  toxicity in  mice.   Ecotoxicol. Environ. Saf.
                (1992)  23(3): 274-81

Org met        Donoghue, D. J., Hairston, H., Cope, C. V., Bartholomew, M. J., and Wagner, D. D.  1994.
                incurred arsenic residues in chicken eggs.   Journal of Food Protection.  57(3): 218-223.

Rev            Doyle, J. J. 1979. toxic and essential elements in bone, a review.  J.Anim.Sci. 49(2): 482-497.

Rev            Doyle, J. J. and Spaulding, J. E.  1978.  toxic and essential trace elements in meat - a review.
                Journal of Animal Science. 47(2): 398-419.

FL             Droumev, D.  and Stojanova, L. 1976.  efficacy of sodium arsanilate and its influence on immunity
                in chickensexperimentally infected with borrelia anserina.  Deutsche Tierarztliche Wochenschrift
                83(5):  221-224.

Unrel           Dube, Benoit, Dunning, Greg, and Lauziere, Kathleen. 1998. geology of the hope brook mine,
                newfoundland, Canada: a preserved late proterozoic high-sulfidation epithermal gold deposit and
                its implications for exploration.   Econ. Geol. (1998)  93(4):  405-436.

In Vit           Dubrow, R., Riddle, V.  G. H., and Pardee, A. B.  1979.  different responses to drugs and serum of
                cells transformed by various means.  Cancer Research.  39 (7 Part 1). 1979. 2718-2726.

Abstract        Earnest, N. M. and Hood, R. D.  1981.  effects of chronic prenatal exposure to sodium arsenite on
                mouse development and Behavior.  Teratology  24(1):53A,1981

Surv            Edwards, W.  C. and Clay, B. R.  1980.  an investigation of an arsenic poisoning case.  Bovine
                Practitioner.  0 (15). 1980. 157-158.

FL             Efthymiou, M. L., Cristofini, P., Pierron, E., and Djezzar, S.  1995. diagnosis of toxic or drug
                induced pancreatitis.   Therapie (Paris). 50(5):  467-468.

Unrel           Egan, H.  1972. pesticides and toxic chemicals.   Proc.  Nutr. Soc.. 31(1):  p23-32.

Rev            Eisler, R. 1927.  a review of arsenic hazards to plants and animals with emphasis on fishery and
                wildlife resources.   Nriagu : Art li: Human Health and Ecosystem Effects. Xv+293p. John Wiley
                and Sons, Inc.: New York,  New York,  Usa; Chichester, England, UK. ISBN 0-471-30436-0.; 0
                (0). 1994. 185-259.

Mix            El-Begearmi, M. M., Ganther, H.  E., and Sunde, M. L. 1982. dietary  interaction between
                methylmercury, selenium, arsenic, and  sulfur amino acids in Japanese quail.  Poult. Sci. (1982)
                61(2):  272-9.

Abstract        El-begearmi,  M. M., Ganther, H. E., and Sunde, M. L.  1975 . more evidence for a selenium
                arsenic interaction in modifying mercury toxicity.  Poult Sci. 49(5): 1756-1757.

Mix            Elgerwi, A. Al-Fateh Univ. Tripoli Libya Faculty of Veterinary Medicine and Bires, J.  1999.
                distribution of minerals in organs of sheep after intoxication with copper from industrial emissions.
                 Czech Journal of Animal Science.  V. 44(11) P. 487-495
Eco-SSLfor Arsenic
51
March 2005

-------
Diss
CP
Mix
Elliott, S. C., Pedersen, N. D., Weswig, P. H., and Whanger, P. D.  1973.  arsenic tissue levels in
rats supplemented with dietary arsenic.  Proc OregAcad Sci.  9. 1973 (RECD 1974) 28

Elsenhans, B., Ademuyiwa, O., Schmolke, G., Schaper, J., andHunder, G. 1993. arsenic-copper
interactions in the kidneys of laboratory animals.  Met.-Met. Interact. fSymp.J  :  110-28.
Editor(s): Elsenhans, Bernd; Forth, Wolfgang; Schuemann, Klaus. Publisher: Bertelsmann Found.
Publ., Guetersloh, Germany. CODEN: 60IEAS.

Elsenhans, B., Schmolke, G., Kolb, K., Stokes, J., and Forth, W.  1987.  metal-metal interactions
among dietary toxic and essential trace metals in the rat.  Ecotoxicol. Environ. Saf. 14(3):  275-
287.
CP
Elsenhans, B., Schuemann, K., Schaefer, S., and Forth, W.  interactions among cadmium arsenic
lead nickel and essential trace elements in rat tissue after dietary Exposure.  Second Joint Meeting
of the Nederlandse Vereniging Voor Toxicologie (Toxicological Society of the Netherlands) and
the British Toxicology Society, Leyden, Netherlands, May 17-19,  1987.  Hum Toxicol.  7 (1).
1988. 78.
No Oral        Erickson, Norman E. 1966. Arsenic in Hair.  U. S. At. Energy Comm. (1966)

Bio Ace         Erry, B. V., Macnair, M. R., Meharg, A. A., Shore, R. F., and Newton, I. 1999. arsenic residues
                in predatory  birds  from an area of britain with naturally and anthropogenically elevated arsenic
                levels.  Environ. Pollut. (1999)  106(1): 91-95.

Surv           Erry, BV, Macnair, MR, Meharg, AA, and Shore, RF.  1999.  seasonal variaition in dietary and
                body organ arsenic concentrations in wood mice apodemus sylvaticus and bank voles
                clethrionomys glareolus.  Bull. Environ. Contam. Toxicol.  63(5):  567-574.

In Vit          Espevik, T., Lamvik, M. K., Sunde, A., and Eik-Nes, K. B.  1982. effects of cadmium on survival
                and morphology of cultured rat sertoli cells.  Journal of Reproduction and Fertility  65(2): 489-
                95.
Unrel
Essig, T. H. 1967Environmental Status of the Hanford Reservation for January-February 1967.
BNWL-CC-1197-1
Unrel
Essig, T. H. 1961 .Environmental Status of the Hanford Reservation for March-April 1967.
BNWL-CC-1197-2
Unrel
Ewer, T. K.  animal Husbandry.  Grunsell, C.s.g. (Ed.), the Veterinary Annual, Issue 11.
Xvi+361p. Illus. John Wright & Sons, Ltd.: Bristol, England; (Dist. In U.S.A.. by Williams &
Wilkins Co.: Baltimore, Md.).  1971 310-335.
Org met        Exon, J. H., Harr, J. R., and Claeys, R. R.  1974. the effects of long term feeding of monosodium
                acid methanearsenate(msma) to rabbits.   Nutrition Reports International 9(5):  351-357.  Ref
                ID: 15382

Surv            Fairbrother, A., Fix, M., O'Hara, T., andRibic, C. A.  1994. impairment of growth and immune
                function of avocet chicks from sites with elevated selenium, arsenic, and boron.  J. Wildl. Dis.
                30(2):  222-233.

No Oral        Falandysz, J.  1986. metals and organochlorines in adult and immature males of white-tailed eagle
                Haliaeetus-albicilla.  Environ Conserv. 13(1): p69-70.
Eco-SSLfor Arsenic
                                   52
March 2005

-------
FL             Falandysz, J. and Jakuczun, B.  1986.  poly chlorinated compounds and trace elements in tissues
                and organs of white-tailed eagle haliaeetus-albicilla.   Bromatol Chem Toksykol.  19(2):  131-133.

FL             Fang, J. F., Kitagawa, Y., Ishikawa, S., Yanagisawa, H., Nakajima, K., Manabe, S., and Wada, O.
                1986. [toxicity assessments of chemical substances using primary culture of rathepatocytes].
                Sangyolgaku  28(6): 438-44.

Phys           Fawcett, T. W., Eastman, H. B., Martindale, J. L., and Holbrook, N. J.  1996.  physical and
                functional association between gadd!53 and ccaat/enhancer-binding protein beta during cellular
                stress.  Journal of Biological Chemistry 271(24): 14285-9.

Rev            Feldman, B. F. and Kruckenberg, S. M.  clinical toxicities of domestic and wild caged birds.  Vet.
                Clin. N.Am. 5(4): 653-673; 1975.(40 References).

InVit          Feldmann, K. and Helmreich, E. J.  1976. the pyridoxal 5' -phosphate site in rabbit skeletal muscle
                glycogen phosphorylase b:  an ultraviolet and Ih and 3 Ip nuclear magnetic resonance
                spectroscopic study.  Biochemistry  15(11): 2394-401.

In Vit          Feldmann, K. and Helmreich, E. J. M. the pyridoxal 5 phosphate site in rabbit skeletal muscle
                glycogen phosphorylase ec-2.4.1.1 an uv and proton nmr and phosphorus-31 NMR spectroscopic
                study.  Biochemistry.  15 (11).  1976 2394-2401.

Bio Ace         Fendick, E. A., Stevens, G. L., Brown, R. I, and Jordan, W. P.  1989. element content in tissues
                of four rodent species sampled in the geysers geothermal steamfield California usa.  Environ
                Pollut. 58(2-3):  155-178.

Mix            Fendick, E. A., Stevens, G. L., Brown, R. J., and Jordan, W. P.  1989. element content in tissues
                of four rodent species sampled in the geysers geothermal steamfield.   Environ. Pollut. (1989)
                58(2-3):  155-78.

Unrel          Feng, J. 1995. improving the iodine supply to humans by iodination of pig feed.   57pp.

No Oral        Perm, V. H.   1977.  arsenic as a teratogenic agent.  Environmental Health Perspectives  19:
                215-7.

No Oral        Perm, V. H. and Carpenter, S. J. 199-201. malformations induced by sodium arsenate.   J.
                REprod. Fertility.; 17(1)

No Oral        Perm, V. H. and Hanlon, D. P.  1985.  constant rate exposure of pregnant hamsters to arsenate
                during early gestation.   Environmental Research  37(2): 425-432.

No Oral        Perm, V. H. and Hanlon, D. P.  1986.  arsenate-induced neural tube defects not influenced by
                constant rate administration of folic acid.  Pediatric Research  20(8): 761-2.

Rev            Perm, V. H., Hanlon, D. P., Clarkson, T. W., Nordberg, G. F., and Sager, P. R. eds. 1983. metal-
                induced congenital malformations.   Reproductive and Developmental Toxicity of Metals.  383-
                398.

Rev            Perm, V. H., Hanlon, D. P., Clarkson, T. W., Nordberg, G. F., and Sager, P. R. eds. 1983. metal-
                induced congenital malformations,  reproductive and developmental toxicity of metals.  Pp. 383-
                398
Eco-SSL for Arsenic                               53                                       March 2005

-------
No Oral        Perm, Vergil H., Saxon, Andrew, and Smith, Bruce M. teratogenic profile of sodium arsenate in
                the golden hamster.  Arch. Environ. Health (1971)  22(5):  557-60.

No Oral         Perm, VH and Kilham, L. 1977. synergistic teratogenic effects of arsenic and hyperthermia in
                hamsters.   Environ. Res. 14: 483-486.

No Oral        Perm, VH, Saxon, A, and Smith, BM.  1971.  the teratogenic profile of sodium arsenate in the
                golden hamster.  Arch. Environ. Health. 22: 557-560.

Orgmet        Ferslew, K. E. and Edds, G. T. 1979. effects of arsanilic acids on growth, serum enzymes,
                hematologicvalues, and residual arsenic in young swine.   American Journal of Veterinary
                Research  40(10):  1365-1369.

Drug            Finnell, R. H. folate receptor knockouts, arsenate and birth defects.   Crisp Data Base National
                Institutes Of Health

In Vit          Fisher, D. L.  cultured rat embryo accumulation of dna, rna and protein following maternal
                administration of sodium Arsenate.   Environ Res. 28 (1).  1982.  1-9.

No Oral        Flora, S. J. S., Pant, S. C., Malhotra, P. R., and Kannan, G. M. biochemical and histopathological
                changes in arsenic-intoxicated rats  coexposed to ethanol.  Alcohol (N.  Y.) (1997)   14(6):  563-
                568

No Oral        Flora, SJS, Kannan, GM, and Kumar, P. 1999.  selenium effects on gallium arsenide induced
                biochemical and immunotoxicological changes in rats.  Chemico-Biological Interactions.  122:
                1-13.

No Dose        Flora, Swaran J. S.  1999. arsenic-induced oxidative stress and its reversibility following
                combined administration of n-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats.   Clin.
                Exp. Pharmacol. Physiol. (1999)  26(11):  865-869

Rev             Fonseca, M. L, Lunt, G. G., and Aguilar, J. S. 1991.  inhibition of muscarinic cholinergic
                receptors by disulfide reducing agents and arsenicals differential effect on locust and rat.
                Biochemical Pharmacology.  41 (5). 1991. 735-742.

Invert          Fonseca, MI, Lunt, GG, and Aguilar, JS.  1991.  inhibition of muscarinic cholinergic receptors by
                disulfide reducing agents and arsenicals.   Bichem. Pharmacol.  41(5): 735-742.

Abstract        Fowler, B. A. and Woods, J.  S. 1976.  ultrastructural and biochemical effects of ingested arsenic
                on rat liver Mitochondria.   Toxicol Appl Pharmacol. 37(1):  121. RefID: 15161

In Vit          Fowler, B. A.  ultrastructural and biochemical alterations of cellular organelles by prenatal
                exposure to toxic trace metals.   ReprodDev ToxicMet(proc JtMeet 1982) :437-451,1983

Rev             Fowler, B. A. and Mahaffey, K. R.  1978.  interactions among lead, cadmium, and arsenic in
                relation to porphyrin excretion patterns.  Environ Health Perspect.  25:  87-90.

In Vitro        Fowler, B. A., Woods, J. S., and Schiller, C. M. 1979. studies of hepatic mitochondria! structure
                and function: morphometric and biochemical evaluation in in vivo perturbation by arsenate.  Lab
                Invest.  41 (4). 1979. 313-320.

Abstract        Fowler, B. A., Woods, J. S., and Schiller, C. M. 1978. effects of arsenic on mitochondrial and
Eco-SSLfor Arsenic
54
March 2005

-------
Surv
Bio Ace
Acute
Prim
Reg
No Oral
Unrel
Rev
Drug
Gene
FL
Phys
Acu
InVit
microsomal oxidative interactions.  Society of Toxicology Seventeenth Annual Meeting: Abstracts
of Papers. In Toxicology and Applied Pharmacology  45(1): 308-309.

Franson J.C., Augspurger T.P., Converse K.A., SpitzerP.R., Miller E.A., BachmannR.W., Jones
J.R., Peters R.H., and Soballe, D. M. (eds.). 1995. necropsy results and concentrations of
mercury, lead, arsenic, and selenium in emaciated loons from the coast of north Carolina in 1993.
Lake Reserv. Manage  Vol. 11, NO. 2: p.  139A.

Franson, J. Christian, Koehl, Philip S., Derksen, Dirk V., Rothe, Thomas C., Bunck, Christine M.,
and Moore, John F.  1995.  heavy metals in seaducks and mussels from misty fjords national
monument in southeast Alaska.   Environ. Monit. Assess.   36(2):  149-67.

Freeman, GB, Johnson, JD, Killinger, JM, Liao, SC, Davis,  Ao, Ruby, MV, Chaney, RL, Lovre,
SC, and Bergstrom, PD.  1993.  bioavailability of arsenic in soil impacted by smelter activities
following oral administration in rabbits.  Fund. Appl. Toxicol.  21: 83-88.

Freeman, GB, Schoof, RA, Ruby, MV, Davis, AO, Dill, JA, Liao, SC, Lapin, CA , and Bergstrom,
PD.  1995. bioavailability of arsenic in soil and house dust impacted by  smelter activities
following oral administration in cynomolgus monkeys.  Fund.  Appl. Toxicol. 28(2):  215-222.

Frey, Michelle M., Owen, Douglas M., Chowdhury, Zaid K., Raucher, Robert S., and  Edwards,
Marc A.  1998.  cost to utilities of a  lower mcl for arsenic.   J. -Am. Water Works Assoc. (1998)
90(3):  89-102.

Friedheim, E. A. H.  1974.  therapeutic field trial of a macro- and microfilaricidal agent incanine
filariasis.  Bulletin of the World Health Organization 50(No.6):  572-574.

Froseth, A. J. 1979. selenium and vitamin e: blood and tissue levels in pigs.  Acta Agriculturae
Scandinavica. (Suppl. 21):  219-231.

Frost, DV, Overby, LR, and Spruth,  HC. 1955. studies with arsanilic acid and related compounds.
 J. Agric. Food Chem. 3:  235.

Funderburk, William H., Foxwell, M., and Ward, John W.  1969. inhibition of release of slow-
reacting substance by arsenic.  Eur. J. Pharmacol. (1969)  5(2): 203-8..

Gabis Kimberly K(A), Gildemeister Otto S, Pepe Joyce A, Lambrecht Richard W, and Bonkovsky
Herbert L. 1996.  induction of heme oxygenase-1 in Imh cells,  comparison of Imh cells to primary
cultures of chick embryo liver cells.   Biochimica Et Biophysica Acta  1290(1):  113-120.

Gabrashanskii, P., Koichev, K. B., and Troev, T.  1986. some diseases in fallow deer  in northeast
bulgaria and their prevention. Veterinarno Meditsinski Nauki.  23(10). 1986 (Reed. 1987). 83-88.

Gainer, J. H. 1973.  activation of the rauscher leukemia virus by metals.  J. Nat. Cancer Inst.
(1973)  51(2):  609-13.

Gainer, J. H. 1977.  effects of interferon of heavy metal excess and zinc deficiency.   AM J VET
RES.  38(6): 863-867.

Gainer, J. H. 1977.  effects on interferon of heavy metal excess and zinc deficiency.   American
Journal of Veterinary Research  3 8(6): 863-7.
Eco-SSLfor Arsenic
                                   55
March 2005

-------
No Oral        Gainer, J. H. and Pry, T. W.   1972. effects of arsenicals on viral infections in mice.  Amer.J.
                Vet. Res. (1972)  33(11): 2299-307.

Bact            Galperin, M. Y., Noll, K. M, and Romano, A. H.  1996. the glucose transport system of the
                hyperthermophilic anaerobic bacterium thermotoga neapolitana.   Vol. 62, No. 8, Pp. 2915-2918
                Appl. Environ. Microbiol.

Rev             Gebel, T.  1997. arsenic and antimony: comparative approach on mechanistic toxicology.
                Chem.Biol.Interact.  107(3):   131-144.

FL             Gencik, Andrej, Szokolayova, Jana, and Cerey, Karol.  dominant  lethal test after peroral
                administration of arsenic.  Bratisl. Lek. Listy (1977)  67(2):  179-87.

Chem Meth     George, G. M. and Frahm, L. J.  1986. graphite furnace atomic absorption spectrophotometric
                determination of 4 hydroxy-3-nitrobenzenearsonic-acid in finished animal feed collaborative
                study. Journal of the Association of Official Analytical Chemists. 69(5).  1986.838-843.

Unrel          Gerard, C. and Troncoso, J.  1980. use of fresh water hyacinth by the broiler rabbit.  Revue
                D'Elevage Et De Medecine Veterinaire Des Pays Tropicaux  33( 1):  91-96.

Mix             Gerber, G. B., Maes, I, and  Eykens, B.  1982. transfer of antimony and arsenic to the developing
                organism.   Arch Toxicol. 49(2):  159-68.

Alt             German, J., Louie, E., and Banerjee, D. 1986. the heat-shock response in vivo: experimental
                induction during mammalian organogenesis.  Teratogenesis, Carcinogenesis, andMutagenesis
                6(6): 555-62.

Mix             Germolec, Dori R., Yang, Raymond S. H., Ackermann, Michael F., Rosenthal, Gary J., Boorman,
                Gary A., Blair, Patricia, and Luster, Michael I. 1989. toxicology studies of a chemical mixture of
                25 groundwater contaminants, ii. immunosuppression in b6c3f 1  mice.  Fundam. Appl. Toxicol.
                (1989)  13(3): 377-87.

No Dose        Ghergariu, S., Roca, R., Mezei, E., and Toth, E.  1994. comparative epidemiology in an area with
                endemic goitre in man andanimals. RevistaRomanaDeMedicinaVeterinara 4(1): 17-23.

Phys            Ghishan, F. K. and Dykes, W. 1993.  ontogeny of phosphate transport by rat liver plasma
                membrane vesicles.   Journal of Developmental Physiology  19(5):  197-201.

CP             Gibbs, P. J.  1992-31820. heavy metal and organochlorine concentrations in tissues of the little
                penguin eudyptula minor.  DANN

HHE           Gibson, R. S. and Gage, L. A. 1982.  changes in hair arsenic levels in breast and bottle fed infants
                during the 1st year of infancy.  Science Of The Total Environment 26(1): 33-40.

CP             Gilani,  S. H. and Alibai, Y. 1985. the effects of heavy metals on the chick embryo development.
                American Association of Anatomists 98th Annual Meeting and the Association Canadienne Des
                Anatomistes (Canadian Association of Anatomists) 29th Annual Meeting

Acu             Gilani,  Shamshad H. New Jersey Medical School Newark and Alibhai, Yasmin New Jersey Inst of
                Technology Newark, teratogenicity of metals to chick embryos.   J Toxicol Environ Health.  V30,
                Nl, P23(9)
Eco-SSLfor Arsenic
56
March 2005

-------
Mix
Surv
Mix
Gilbert, F. R., Wells, G. A. H., and Gunning, R. F. 1981. 3-nitro-4-hydroxyphenylarsonic acid
toxicity in pigs.  Veterinary Record  109(8): 158-160.

Gill, J. M. and Darby, J. T.  1993. deaths in yellow-eyed penguins (megadyptes antipodes) on the
otagopeninsula during the summer of 1990.  New Zealand Veterinary Journal.  41(1): 39-42.

Gilmartin, JE, Alo, DK, Richmond, ME, Bache, CA, and Lisk, DJ.  1985.  lead in tissues of cats
fed pine voles from lead arsenate-treated orchards.  Bull. Environ.  Contam. Toxicol.  34(2): 291-
294.
No Oral        Gladney, W. J. and Dawkins, C. C.  1976.  the brown dog tick: laboratory tests of acaricides.
                Southwestern Entomologist 1(4):  184-189.

Surv           Goede, A. A., Nygard, T., de Bruin, M., and Steinnes, E.  1989. selenium, mercury, arsenic and
                cadmium in the lifecycle of the dunlin, calidris alpina, a migrant wader.  Science of the Total
                Environment. 78(1):  205-218.

Bio Ace         Goede, AA. 1985. mercury, selenium, arsenic and zinc in waders from the dutch wadden sea.
                Environ. Pollution (SeriesA).  37:  287-309.

CP             Goeneches, S., Fischer, B., Fischer, K., and Koehler, F.  1983. dose-related incorporation of
                arsenic into organs in pregnant mice  following chronic oral administration of arsenic.  Anorg.
                Stoffe Toxikol. Krim. Symp.  91-9 Publisher: Verlag Dr. Dieter Helm, Heppenheim, Fed. Rep. Ger.
                CODEN: 52GUAX.

Aquatic         Goldberg, E. D.  \912.Baseline Studies of Pollutants in the Marine Environment and Research
                Recommendations. NSF/IDOE-74-26

No COC        Goldman, M. and Dacre, J. C.  1989. lewisite: its chemistry, toxicology,  and biological effects.
                Reviews of Environmental Contamination and Toxicology  110: 75-115.

FL             Golikov, S. N., Gur'yanov, G.  A., and Kozlov, V. K.  1986. specific antibodies as modulators of
                the effects of physiologically active substances and xenobiotics the principle phenomena.
                Uspekhi Sovremennoi Biologii. 102(2). 1986 (Reed. 1987). 193-206.

Rev            Golub, M. S.  1994.  maternal  toxicity and the identification of inorganic  arsenic as a
                developmental toxicant.  Reproductive Toxicology.  8 (4):  283-295.

Mix            Golub, Mari S., Keen, Carl L., Commisso, Joel F., Salocks, Charles B., and Hathaway, T. R.
                1999. arsenic tissue concentration of immature  mice  one hour after oral exposure to gold mine
                tailings.   Environ. Geochem. Health (1999)  21(3):  199-209.

Rev            Golub, Mari S., Macintosh, Michael S., and Baumrind, Nikki.  1998. developmental and
                reproductive  toxicity of inorganic arsenic: animal studies and human concerns.  J. Toxicol.
                Environ. Health  Part B (1998): 1(3), 199-241.

Fate            Gonzalez, M. I, Aguilar, M. V., and Martinez, Para Me.  1995. gastrointestinal absorption of
                inorganic arsenic v the effect of concentration and interactions with phosphate and dichromate.
                Veterinary and Human Toxicology.  37(2): 131-136.

HHE           Goyer, R. A.  1976.  toxicology of lead on kidney and other organs.   Health Effects of
                Occupational Lead and Arsenic Exposure: a Symposium; Carnow B. W.,  Ed.
Eco-SSLfor Arsenic
                                   57
March 2005

-------
No COC        Gray, L. Earl Jr(A) and Ostby Joseph S. 1993. the effects of prenatal administration of azo dyes
                on testicular development in the mouse: a structure activity profile of dyes derived from benzidine,
                dimethylbenzidine, or dimethoxybenzidine.  Fundamental and Applied Toxicology  20(2):  177-
                183.
No COC
Drug
Unrel
CP
Gene
No oral
Gray, LE and Ostby, JS. 1993. the effects of prenatal administration of azo dyes on testicular
development in the mouse: a structure activity profile of dyes derived from benzidine,
dimetylbenzidine, or dimethoxybenzidine.  Fundamental Appl. Toxicol.  20:  177-183.
Graziano, J. H., Cuccia, D., and Friedheim, E.
acid and its potential use in arsenic poisoning.
Therapeutics  207(3):  1051-5.
1978. the pharmacology of 2,3-dimercaptosuccinic
 Journal of Pharmacology and Experimental
Greaves, T., Mclnnes, R. S., and Dowse, J. E.  \966.The Control of Termites (Coptotermes Spp.)
in Blackbutt (Eucalyptus Pilularis)

Green, E., Inns, R. H., and Bright, J. E.  1990.  pyruvate measurement in rabbit tissues as a
measure of arsenic Intoxication.  Proceedings of the British Toxicology Society

Groff, J. L. and Haurowitz, F. 1963 .Comparison of the Peptide Maps ofAnti= Bodies Against an
Acidic and a Basic Determinant Group : 2p.

Groth, D. H., Stettler, L. E., and Burg, J. R. 1986.  carcinogenic effects of antimony trioxide and
antimony ore concentrate in rats.  J Toxicol Environ Health.  18:  607-626.
Mix
Gry, J., Bille, N., Kristiansen, E., Madsen, C., Meyer, O., Olsen, P., Roswall, K., Thorup, L, and
Wurtzen, G.  1988. thermally oxidized soya bean oil interacted with mono- and diglycerides of
food fatty acids (esters of glycerol and thermally oxidized soybean fatty acids):  a long-term study
in  rats.  Publ. - Levnedsmiddelstyr.  (Den.) (1988) :  172, 154 pp. CODEN: PULEE4; ISSN:
0901-4322.
Surv           Guitart, R., Torra, M, Cerradelo, S., Puig-Casado, P., Mateo, R., and To-Figueras, J.  1994.  pb,
                cd, as, and se concentrations in livers of dead wild birds from the ebro delta, spain.  Bull.
                Environ. Contam. Toxicol. 52(4): 523-529.

InVit          Gurley, L. R., Walters, R. A., Jett, J. H., and Tobey, R. A.  1980.  response of cho cell
                proliferation and histone phosphorylation to sodium arsenite.  Journal of Toxicology and
                Environmental Health  6(1): 87-105.

Unrel          Haas, A. L., Warms, J. V., and Rose, I. A.  1983. ubiquitin adenylate: structure and role in
                ubiquitin activation.   Biochemistry  22(19):  4388-94.

No COC        Hackett, P. L., Sasser, L. B., Rommereim, R. L., Gushing, J. A., and Buschbom, R. L. 1987.
                Teratology Studies of Lewisite and Sulfur Mustard Agents: Effects of Lewisite in Rats and Rabbits.
                 Final Rept.  15 May 83-28 Feb 8.  PNL-6408

Acu            Haegele, M. A. and Tucker, R. K. 1974. effects of 15 common environmental pollutants on
                eggshell thickness in mallards and coturnix.  Bull Environ Contam Toxicol.  11(1): 98-102.

Surv           Halbrook, R.  S., Brewer, R. L., and Buehler, D. A.  1999. ecological risk assessment in a large
                river-reservoir. 7. environmental contaminant acccumulation and effects in great blue heron.
                Environmental Toxicology And Chemistry / 18(4): 641-648.
Eco-SSLfor Arsenic
                                   58
                                  March 2005

-------
Surv           Hall, L. W. Jr and Burton, D. T.  1982. effectsof power plant coal pile and coal waste runoff and
                leachate on aquatic biota: an overview with research recommendations.   CritRev Toxicol. 10(4):
                287-301 (REF: 116).

Bio Ace         Halverson, A. W., Tsay, D. T., Triebwasser, K. C., and Whitehead, E. I.  1970. development of
                hemolytic anemia in rats fed selenite.   Toxicol. Appl. Pharmacol. 17(1): 151-159.

Mix            Halverson, Andrew W., Tsay, Ding-Tsair, Triebwasser, K. C., and Whitehead, E. I.  1970.
                development of hemolytic anemia in  rats fed selenite.  Toxicol. Appl. Pharmacol.  (1970)
                17(1):  151-9.

Carcin         Hanlon, D. P. and Perm, V H. 1986.  teratogen concentration changes as the basis of the heat
                stress enhancement of arsenate teratogenesis in hamsters.  Teratology. 34 (2). 1986. 189-194.

No Oral        Hanlon, David P. and Perm, Vergil H.  1986. concentration and chemical status of arsenic in the
                blood of pregnant hamsters  during critical embryogenesis.  Environ. Res. (1986)  40(2):  380-90


No Oral        Hanlon, David P. and Perm, Vergil H.  1986.  concentration and chemical status of arsenic in the
                blood of pregnant hamsters  during critical embryogenesis.  1.  subchronic exposure to arsenate
                utilizing constant rate administration.   Environ. Res. (1986) 40(2): 372-9.

No oral         Hanlon, DP and Perm, VH.  1986.  concentration and chemical status of arsenic in the blood of
                pregnant hamsters during critical embryogenesis. 2.  acute exposure.  Environ. Res.  40(2): 380-
                390.

Abstract        Hanna, L., Peters, J. M, Wiley, L. M, Clegg, M. S., and Keen, C. L. 1996. comparative effects
                of essential and nonessential metals on preimplantation mouse embryo development.
                Experimental Biology 96

FL             Hapke, H. J. 1971. (general lexicological viewpoints in the use of pesticides, particularly
                weedkillers.).  Tieraerztl. Umschau; 26(4): 149-52  1971

Unrel           Harris, T.  K., Cole, R. N., Comer, P. L, and Mildvan, A.  S.  1998. proton transfer in the
                mechanism of triosephosphate isomerase.  Biochemistry  37(47): 16828-38.

Abstract        Harrison, W. P. and Hood, R. D. 1981. prenatal effects following exposure of hamsters to sodium
                arsenite by oral or intraperitoneal routes.   Teratology. 23:40A,1981

CP             Hartig, P.  C. and Hunter, E. S. 1998.  effects of overexpression of human p53 on arsenite-induced
                dysmorphology on mouse embryos in Culture.   Thirty-eighth Annual Meeting of the Teratology
                Society and the 22nd Annual Meeting of the Neurobehavioral Teratology Society and llth
                International Conference of the Organization of Teratology Information

In Vit           Hatayama, T., Takahashi, H., and Yamagishi, N.  1997. reduced induction of hsp70 in pc!2 cells
                during neuronal differentiation.   Journal of Biochemistry  122(5):  904-10.

Acu            Hatch,  R.  C., Clark, J. D., and Jain, A. V.  1978. use of thiols and thiosulfate for treatment of
                experimentally inducedacute arsenite toxicosis in cattle.  American  Journal of Veterinary
                Research  39(9):  1411-1414.

No Oral        Hattori, K., Nishikawa, M.,Fujita, K., Mashiko, M., Arima, T., andlchiki, Y.  1983. epidermal
Eco-SSLfor Arsenic
59
March 2005

-------
Phys
InVit
Mix
Phys
Rev
and follicular changes on the mouse skin induced by arsenic trioxide solution (arsenous acid)
administration as drinking water: microscopic and ultrastructural Studies.   JNatl DefMed Coll.
8 (2). 1983. 132-138.

Hauser, G. I, Dayao, E. K., Wasserloos, K., Pitt, B. R., and Wong, H. R.  1996. hsp induction
inhibits inos mrna expression and attenuates hypotension in endotoxin-challenged rats.   American
Journal of Physiology  271(6 Pt 2): H2529-35.

Haveman, I, Li, G. C.,  Mak, J. Y., and Kipp, J. B. A.  1986.  chemically induced resistance to
heat treatment and stress protein synthesis in cultured mammalian cells. International Journal of
Radiation Biology & Related Studies in Physics Chemistry & Medicine. 50 (1). 1986. 51-64.

Haynes, R., Minyard, J., Collins, J., Sparks, T., and Hill, J. 1980. weight gains and arsenic
depletion rate in steers fed broiler litter.   Res. Rep. - Miss. Agric. For. Exp. Stn. (1980). 5(5): 4
pp.

Head Mark W(A), Corbin Elaine, and Goldman James E. 1994. coordinate and independent
regulation of alpha-b-crystallin and hsp27 expression in response to physiological stress.   Journal
of Cellular Physiology  159(1): 41-50.

Healy, Sheila M,  Wildfang, Eric, Zakharyan, Robert A., and Aposhian, H. Vasken. 1999.
diversity of inorganic arsenite biotransformation.  Biol. Trace Elem. Res. (1999)  68(3): 249-266
No COC        Hedlund, B., Norm, H., Christakopoulos, A., Alberts, P., and Bartfai, T.  1982.
                acetylarsenocholine: a cholinergic agonist.  Journal of Neurochemistry  39(3):  871-3.

Mix            Heindel, J. I,  George, J. D., and Fail, P. A.  1990.  final report on the reproductive toxicity of a
                chemical mixture in cd-1-Swiss mice: volume 2, laboratory supplement.  NTIS Technical Report
                (NTIS/PB91-158451) 1990 Nov;:189 Pp.

Mix            Heindel, Jerold J., Chapin, Robert E., George, Julia, Gulati, Dushyant K., Fail, Patricia A., Barnes,
                Leta H., and Yang, Raymond S. H.  1995. assessment of the  reproductive  toxicity of a complex
                mixture of 25 groundwater contaminants in  mice  and rats.  Fun dam. Appl. Toxicol.  25(1): 9-
                19.

HHE           Henderson, P., Hale, T. W., Shum, S., and Habersang, R. W.  1985.  n-acetylcysteine therapy of
                acute heavy metal poisoning in mice.   Veterinary and Human Toxicology  27(6): 522-5.

No Oral        Henderson, P., Hale, T. W., Shum, Shu, and Habersang, R. W. 1985.  n-acetylcysteine therapy of
                acute heavy metal poisoning in  mice.   Vet. Hum.  Toxicol. (1985)  27(6): 522-5.

In Vit          Henle, K.  J., Norris, J. S., and Lumpkin, C. K.  1990. heat-induced protein dephosphorylation in
                Chinese hamster ovary cells.  Biomedica Biochimica Acta 49(1):  35-44.

Surv           Henny, C. J., Blus, L. J., and Grove, R. A. western grebe, aechmophorus occidentalis, wintering
                biology and contaminant accumulation in commencement bay, Puget sound, Washington (usa).
                Can Field-nat; 104 (3). 1990. 460-472.

Phys           Henriksen, E. J.  1991. effects of phenylarsine oxide on insulin-stimulated system a amino acid
                uptake in skeletal muscle.  American Journal  of Physiology  261(4 Pt 1):  C608-13 .
Eco-SSLfor Arsenic
                                   60
March 2005

-------
Aquatic         Herbel, M. I, Tanji, K. K., Dahlgren, R. A., and Gao, S.  1996.  acidification of agricultural
                evaporation ponds: effects on traceelement chemistry in sediment-water core microcosms.
                Journal of Environmental Quality  25(4): 732-742.

Abstract         Hermayer, K. L., Stake, P. E., and Shippe, R. L.  1977. evaluation of dietary zinc, cadmium, tin,
                lead, bismuth and arsenictoxicity in hens.  Poult. Sci.  56(5):  1721-1722.

Prim            Hey wood, R. and Sortwell, R. J. arsenic intoxication in the rhesus  monkey.   Toxicol. Lett.
                (1979)  3(3):  137-44..
CP
Hill, C. H.  reductions in mortality of phosphorus deficient chicks by vanadium arsenic selenium
and cadmium.   Meeting of the Federation of American Societies for Experimental Biology
(Faseb) Part li, Anaheim, California, Usa, April 5-9, 1992. Faseb (Fed Am Soc Exp Biol) J. 6 (5).
1992. A1651.
Rev
Hill, C. H.  1975.  interrelationships of selenium with other trace elements.  Fed. Proc.  34(11):
2096-2100.
Rev            Hill, C. H. and Matrone, G. 1970. chemical parameters in the study of in vivo and in vitro
                interactions of transition elements.  Federation Proceedings.  29(4): 1474-81.

Acu            Hill, E. F., Heath, R. G., Spann, J. W., Spann, J. W., and Williams, J. D.  1975.

Mix            Hilliard, E. P. and Pearce, G. R. 1978.  limitations of guidelines governing rates of application of
                pig manure to land.  Agriculture and Environment.  4 (1). 1978 65-76.

No Dose        Hilliard, E. P. and Pearce, G. R. 1936.  variability in the composition of commercial pig diets with
                particularreference to minerals.  Australian Journal of Experimental Agriculture and Animal
                Husbandry
Acu
Acute
Hilmy, A. M., El-Domiaty, N. A., Kamal, M. A., Mohamed, M. A., and Abou Samra, W. E.  1991.
effect of some arsenic antagonists on the toxicity, distribution and excretion of arsenite and
arsenate in rats.  Comp. Biochem. Physiol. C: Comp. Pharmacol.  Toxicol.   99C(3):  357-62

Hirata, M, Tanaka, A, Hisanaga, A, and Ishinishi, N.  1990. effects of glutathione depletion on the
acute nephrotoxic potential of arsenite and on arsenic metabolism in hamsters.  Toxicol Applied
Pharmacol.  106:  496-481.
Acute           Hirata, Miyuki, Tanaka, Akiyo, Hisanaga, Akira, and Ishinishi, Noburu.  1990. effects of
                glutathione depletion on the acute nephrotoxic potential of arsenite and on arsenic metabolism in
                hamsters.   Toxicol. Appl. Pharmacol. (1990)  106(3):  469-81.

Nut def         Hirunuma, R., Sotogaku, N., Endo, K., Enomoto, S., Ambe, S., and Ambe, F.  1999. time
                dependence of distribution of radioactive trace elements in se-deficient rats  . application of the
                multitracer technique.  J. Radioanal. Nucl. Chem. (1999)  239(1): 213-215.

Acu            Hochadel, J. F. and Waalkes, M. P.  1997. sequence of exposure to cadmium and arsenic
                determines the extent of toxic effects in male fischer rats.   Toxicology 116(1-3):  89-98.

Diss            Hodel, M.  \994.Untersuchungen Zur Festlegung UndMobilisierung Der Elemente As, Cd, Ni
                UndPb anAusgewaehltenFestphasen Unter Besonderer Beruecksichtiguung Des Einflusses Von
                Huminstoffen. (Investigation into the Immobilization and Mobilization of the Elements As, Cd, Ni
Eco-SSLfor Arsenic
                                   61
March 2005

-------
                andPb at Selected Solid Phases With Special Regard to the Influence of Humic Matter).
                 Diss. (Dr.Rer.Nat.)

Surv           Hoernfeldt, Birger and Nyholm, N. Erik I.  1996.  breeding performance of tengmalm's owl in a
                heavy metal pollution gradient.  J.Appl.Ecol.   33(2): 377-386.

Rev            Hoffman, D. J. measurements of toxicity and critical stages of development, wildlife toxicology
                and population modeling: integrated studiesof agroecosystems .   (SETA C Special Publications
                Series) 1994;:47-7

Rev            Hoffman, D. J. 1994. measurements of toxicity and critical stages of development.    Wildlife
                Toxicology and Population Modeling: Integrated Studies ofAgroecosystems (SETAC Special
                Publications Series) .: 47-7.

No Oral        Holmberg, R. Jr.  1969.  interrelationships of selenium, cadmium and arsenic in mammalian
                teratogenesis.  Arch. Environ. Health.  18(6):  837-7.

No Oral        Holmberg REFermVH Jr.  837. interrelationships of selenium, cadmium and arsenic in
                mammalian teratogenesis.   Arch. Environ. Health; 18(6)

No Oral        Holson, J. F., Stump, D. G., Ulrich, C. E., and Farr, C. H.  1999.  absence of prenatal
                developmental toxicity from inhaled arsenic trioxide in Rats.  Toxicological Sciences. 51 (1).
                1999. 87-97.

No Oral        Holson, JF, Stump, DG, Urlich, CE, and Farr, CH.  1999.  absence of prenatal developmental
                toxicity from inhaled arsenic trioxide in rats.  Toxicological Sciences. 51(1):  87-97.

Mix            Hong, H. L., Yang, R. S. H., and Boorman, G. A.  residual damage to hematopoietic system in
                mice  exposed to a mixture of groundwater contaminants.  Toxicol. Lett. (1991)  57(1):  101-11.

Mix            Hong, H. L., Yang, R. S. H., and Boorman, G. A.  1992.  alterations in hematopoietic responses in
                b6c3f 1  mice  caused by drinking a mixture of 25 groundwater contaminants.   J. Environ.
                Pathol. Toxicol. Oncol.   11(2): 65-74 .

Mix            Hong, H. L., Yang, R. S. H., and Boorman, G. A.  1993.  enhancement of myelotoxicity induced
                by repeated irradiation in mice exposed to a mixture of groundwater contaminants.  Arch.
                Toxicol.  67(5):  358-64.

Acu            Hood, R. D., Thacker, G. T., Patterson, B. L., and et, a. 1.  1978. prenatal effects of oral versus
                intraperitoneal sodium arsenate in Mice.  Journal of Environmental Pathology and Toxicology
                1(6):  857-864.

CP             Hood, R. D.  1981.  toxicology of prenatal exposure to arsenic.   Arsenic:indBiomed Environ
                Perspect Proc Arsenic Symp 1981 134-150,1983

No Oral        Hood, R. D.  1998.  developmental effects of methylated arsenic metabolites in mice.   Bulletin Of
                Environmental Contamination And Toxicology.  61(2):  231-238.

Abstract        Hood, R. D., Baxley, M. N., and Harrison, W.  P.  1979.  evaluation of chromated copper
                arsenate(cca)for Teratogenicity.  Teratology 19:31A, 1979

Abstract        Hood, R. D., Baxley, M. N., and Harrison, W. P. 1979. evaluation of chromated copper arsenate
Eco-SSLfor Arsenic
62
March 2005

-------
                for teratogenicity.  Teratology. 19 (2). 1979 3la

No Oral         Hood, R. D., Harrison, W. P., and Vedel, G. C.  1982. evaluation of arsenic metabolites for
                prenatal effects in the Hamster.  Bull Environ Contain Toxicol 29:679-687,1982

Abstract        Hood, R. D., Harrison, W. P., and Vedel, G. C. 1982. prenatal effects of arsenic metabolites in
                the Hamster.  Teratology 25(2) :50A, 1982

Abstract        Hood, R. D., Nemec, M. D., Holson, J. F., and Farr, C. H.  1988. effects of mid-gestational
                exposure of mice and rabbits to arsenic acid.   Toxicologist 1998 Mar;42(l-S):258

Dup            Hood, R. D., Thacker, G. T., Patterson, B. L., and Szczech, G. M. 1978. pre natal effects of oral
                vs intra peritoneal sodium arsenate in mice.. Journal of Environmental Pathology and Toxicology.
                1 (6). 1978. 857-864.

Mix            Hood, R. D. and Vedel-Macrander, G. C.  1984.  evaluation of the effect of bal (2,3-
                dimercaptopropanol) on arsenite -induced teratogenesis in mice.  Toxicology and Applied
                Pharmacology 73(1): 1-7.

Acute          Hood, RD.  1972. effects of sodium arsenite on fetal development.   Bull. Environ. Contam.
                Toxicol. 7(4): 216-222.

Orgmet        Hood, RD.  1998. developmental  effects of methylated arsenic metabolites in mice.   Bull.
                Environ. Contam. Toxicol. 61: 231-238.

No Oral        Hood, RD and Bishop, SL. 1972.  teratogenic effects of sodium arsenate in mice.  Arch, Environ.
                Health.  24(1): 62-65.

No oral         Hood, RD, Harrison, WP, and Vedel, GC.  1982. evaluation of arsenic metabolites for prenantal
                effects in the hamster.  Bull.  Environ. Contam. Toxicol.  29(6): 679-687.

Acute          Hood, RD, Thacker, GT, and Patterson, BL. 1977. effects in the mouse and rat of prenatal
                exposure to arsenic.   Env Health  Perspect. 19:  219-222.

CP             Hood, Ronald D. arsenic as a teratogen.  DOE Symp. Ser. (1978)  Volume Date 1977, 47(Dev.
                Toxicol. Energy-Relat. Pollut):  536-44.

No Oral         Hood, Ronald D. 1972.   effects of sodium arsenite on fetal  development.  Bull. Environ.
                Contam. Toxicol. (1972)  7(4): 216-22.

No Oral        Hood, Ronald D. embryonic, placenta!, and maternal uptake and retention of dimethylarsinic acid
                by species relatively sensitive ( rat ) or resistant ( mouse ) to its  developmental  toxicity.  Res.
                Commun. Pharmacol. Toxicol. (1998) 3(3 & 4):  99-104 CODEN: RCPTFY; ISSN:  1087-1101.

No Oral        Hood Ronald D.  1972. effects of solium arsenite on fetal development.   Bulletin of
                Environmental Contamination and Toxicology, 7(4): 216-222, April 1972

No Oral        Hood, Ronald D. and Bishop, Sally L. 1972.   teratogenic effects of sodium arsenate  in  mice.
                Arch. Environ. Health (1972) 24(1): 62-5.

Acute           Hood, Ronald D. and Harrison, William P. 1982.  effects of prenatal arsenite exposure in the
                hamster.  Bull. Environ. Contam. Toxicol. (1982)  29(6):  671-8.
Eco-SSLfor Arsenic
63
March 2005

-------
No Oral        Hood, Ronald D. and Pike, Charles T.  1972.  bal [2,3-dimercaptopropanol] alleviation of arsenate-
                induced teratogenesis in  mice.    Teratology (1972)   6(2): 235-7.

Dup            Hood, Ronald D., Thacker, Gary T., Patterson, Barbara L., and Szczech, George M.  1978.
                prenatal effects of oral versus intraperitoneal sodium arsenate in mice.  J. Environ. Pathol.
                Toxicol. (1978)  1(6): 857-64.

Unrel           Hooghe, R. J., Maisin, J. R., Vander Plaetse, F., Urbain, J., and Urbain-Vansanten, G.  1988.  the
                effect of prenatal or early postnatal irradiation on the production of anti-arsonate antibodies and
                cross-reactive idiotypes.  International Journal of Radiation Biology and Related Studies in

Herp           Hopkins, W. A., Mendonca, M.  T., Rowe, C. L., and Congdon, J.  D. 1998. elevated trace element
                concentrations in southern toads, bufo terrestris, exposed to coal combustion waste.  Arch
                Environ Contain Toxicol. 35(2): 325-9.

Surv           Hornfeldt, B. andNyholm, N. EL  1996.  breeding performance of tengmalm's owl in a heavy
                metal pollution gradient.   Journal of Applied Ecology.  33(2): 377-386.

No Oral        Horovitz, C. T. and ZIV, G.  1988. susceptibility of staphylococcus-aureus of bovine udder origin
                to antimicrobial drugs and heavy Metals.  IsrJVetMed.  44(2).   119-123.

Surv           Hothem, R. L. and Ohlendorf, H. M. 1989. contaminants in foods of aquatic birds at kesterson
                reservoir California usa 1985.  Arch Environ Contain Toxicol. 18(6): 773-786.

Surv           Hothem, R. L. and Welsh, D.  1994. contaminants in eggs of aquatic birds from the grasslands of
                central California.    Arch Environ Contam Toxicol. 27(2):  180-5.

Abstract        Howell, G and Hill, CH.  1977.  effects of arsenic in chicks.  Fed. Proc.  36:  1094.

Rev             Howell, J. M.,  Masters, D. G.,  and White, C. L.  1996.  toxicities and excessive intakes
                of minerals. detection and treatment of mineral nutrition problems in grazingsheep.    95-
                117.
Rev
Unrel
InVit
Surv
Acu
Rev
Howell, J. M., Masters, D. G., and White, C. L. 1996. toxicities and excessive intakes of
minerals.   Detection and Treatment of Mineral Nutrition Problems in Grazing Sheep.  95-117.

Howick, C. D. and Creffield, J. W.  1975. the development of a standard laboratory bio-assay
technique with Mastotermes darwiniensisfroggatt  (isoptera: mastotermitidae).  Zeitschrift Fur
Angewandte Entomologie. 78(2):  126-138.

Huang, H., Huang, C. F., Wu, D. R., Jinn, C. M., and Jan, K. Y.  1993.  glutathione as a cellular
defence against arsenite toxicity in cultured Chinese hamster ovary cells.   Toxicology (1993)
79(3):  195-204..

Hudec, K., Kredl, F., Pellantova, J., Svobodnik, J.,  and Svobodova, R.  1988.  residues of
chlorinated pesticides pcb and heavy metals in the eggs of water birds in southern moravia
Czechoslovakia.  Folia Zoo/.  37(2): p!57-166.

Hudson, R, Tucker, R, and Haegele M.  1984.  handbook of toxicity of pesticides to wildlife.   US
Fish and Wildlife Service Resource Publication. 153.:  90.

Hueper, WC and Payne, WW.  1962.  experimental studies in metal carcinogenesis.   Arch.
Eco-SSLfor Arsenic
                                    64
March 2005

-------
                Environ. Health.  5: 445-462.
Surv
Mix
CP
CP
Acute
Acu
Hui, Clifford A.  1998. metal and trace element burdens in two shorebird species at two sympatric
wintering sites in southern California.   Environ. Monit. Assess. (1998)  50(3): 233-247.

 Hullinger, G., Sangster, L., Colvin, B., and Frazier, K.  1998. bovine arsenic toxicosis from
ingestion of ashed copper-chrome-arsenatetreated timber.  Veterinary and Human Toxicology
40(3):  147-148.

Hunter, E. S.  1998. selenite prevents the dysmorphology and early phase cell cycle changes
produced by arsenite in mouse embryos in Culture.  Thirty-eighth Annual Meeting of the
Teratology Society and the 22nd Annual Meeting of the Neurobehavioral Teratology Society and
llth International Conference of the Organization of Teratology Information

Hunter, E. S lii, Elstein, K. H., and Zucker, R. M. 1997. studies of the pathogenesis of arsenite-
induced Dysmorphology.  Joint Meeting of the Teratology Society Thirty-seventh Annual Meeting
and Tenth International Conference of the Organization of Teratology Information Services

Inamasu, T.  1983.  arsenic metabolites in urine and feces of hamsters pretreated with pcb.
Toxicol Appl Pharmacol. 71: 142-152.

 Inns, R.  H., Bright, J. E., and Marrs, T. C.  1988.  comparative acute  systemic toxicity of
sodium arsenite and dichloro(2-chlorovinyl)arsine in  rabbits.  Toxicology (1988) 51(2-3): 213-
22.
CP
Drug
FL
Inns, R. H., Bright, J. E., and Marrs, T. C. 1986. comparative acute toxicity of sodium arsenite
and dichloro-2-chlorovinylarsine.   British Toxicology Society Meeting

 Inns, R. H., Rice, P., Bright, J. E., and Marrs, T. C. 1990. evaluation of the efficacy of
dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits.
Human & Experimental Toxicology 9(4): 215-20.

Inouye, M.  1989. teratology of heavy metals: mercury and other contaminants.  Senten Ijo
1989;29:333-44 29: 333-344.
Rev            Int Task Group Metal Interact. 1978. factors influencing metabolism and toxicity of metals a
                consensus Report.  Environ Health Perspect.   (25). 1978 3-41

Abstract        Irgolic, KJ and Irvin, TR.  1987.  arsenic compounds in water and organisms.  Abstr. Pap. Am.
                Chem.Soc.  194:  3264.
FL
Acu
 Isar, M., Isar, O., Poleacu, L, Bellea, S., Groza, L, Nemteanu, S., Popescu, V., Raducanescu, H.,
Popii, V. B., Togoe, L, Borhan, G., Popescu, L, Bosinceanu, M., lacoban, N., and Boier, L.  1983.
effect of biological sludge given to piglets and fattening pigs.  Lucrarile Stiintifice Ale Institutului
De Biologie Si Nutritie Animala  12: 59-72.

Ishida, Kazuo and Shirakawa, Takako.  1969.  histopathological studies of liver and kidney of
mice  injected with  lethal  doses of pesticides.  Niigata Norin Kenkyu (1969) :  No. 21, 183-
201..
FL
Ishinishi, Noburu, Tomita, Masako, and Hisanaga, Akira. 1980. chronic toxicity of arsenic
trioxide in  rats  with special reference to liver damages.  Fukuokalgaku Zasshi (1980)  71(1):
Eco-SSLfor Arsenic
                                    65
March 2005

-------
                27-40
FL
CP
InVit



Reg


Org met
Ishizaki, Mutsuo.  1980.  studies on pharmacokinetics of arsenicals in  rats.   Nippon Eiseigaku
Zasshi(1980)  35(3):  584-96.

Ishizaki, Mutsuo, Ueno, Seiichi, Oyamada, Noritaka, Kubota, Kaoru, Yamaguchi, Seiya, and
Fujiki, Motoo. 1979. studies on arsenical behavior  in rats.   Kankyo Osen Busshitsu to Sono
Tokishikorojii Shinpojumu [Koen Yoshishu], 6th  : 93-4 Publisher: Nagasaki-shi Ishi Kaikan,
Nagasaki, Japan.

Jacobs, J., Roussel, R., Roberts, M., Marek, D., Wood, S., Walton, H., Dwyer, B., Sinclair, P., and
Sinclair, J. 1998.  effect of arsenite on induction of cypla and cyp2h in primary cultures of chick
Hepatocytes.   Toxicology and Applied Pharmacology.  150(2). 1998.376-382.

Jacobson-Kram, D. and Montalbano, D.   1985. the reproductive effects assessment group's report
on the mutagenicity of inorganic arsenic.  Environmental Mutagenesis  7(5): 787-804.

Jaghabir, MTW, Abdelghani, AA, and Anderson, AC.  1989. histopathological effects of
monosodium methanearsonate on new Zealand white  rabbits (Oryctalagus cuniculus).   Bull.
Environ. Contain.  Toxicol. 42: 289-293.
No Control      James, L. F., Lazar, V. A., and Binns, W.  1966.  effects of sublethal doses of certain minerals on
                pregnant ewes and fetal development.  Am J Vet Res. 27(116): 132-135.

Unrel           Japenga, J., Zschuppe, K. H., De Groot, A J., and Salomons, W. 1990. heavy metals and organic
                micropollutants in floodplains of the river waal (netherlands) a distributary of the river rhine,
                (netherlands), 1958-1981.  NETHJAGRIC SCI. 38(3A): 381-397.

HHE           Jelovsek, Frederick R., Mattison, Donald R.,  and Chen, James J. 1989. prediction of risk for
                human  developmental  toxicity: how important are animal studies for hazard identification?
                Obstet. Gynecol. (N. Y.) (1989)  74(4): 624-36 .

FL             Jennings, F. W.  1988. the potentiation of arsenicals with difluoromethylornithine (DFMO):
                experimental studies in murine trypanosomiasis.  Bulletin De La Societe De Pathologie Exotique
                Et De Ses Filiales; 81  (3

Unrel           Jennings, F. W., Gichuki, C. W., Kennedy, P. G., Rodgers, J., Hunter, C. A., Murray, M., and
                Burke, J. M.  1997. the role of the polyamine inhibitor eflornithine in the neuropathogenesis of
                experimental murine african trypanosomiasis.  Neuropathology and Applied Neurobiology
                23(3): 225-34.

Surv           Johnson, E. V.,  Mack, G. L., and Thompson, D. Q.  1976.  effects of orchard pesticide applications
                on breeding Robins.   Wilson Bull.  88: 16-35.

Drug           Johnson, P. W., Boray, J. C., and Plant, J. W.  1989. itchmite in sheep.   Wool Technology and
                Sheep Breeding  37(3):  136-145.

Rev            Jones-Davies, W. J.  1972.  tick control and a history of tick resistance.   Rhodesian Veterinary
                Journal  2(No.4): 53-59.

No Oral        Jorgensen, M., Grosvik, B. E., Hamre, K., and Goksoyr, A. 1998.  induction of heme oxygenase
                in fish by heavy metals, phenylhydrazineand high lipid diets.  Marine Environmental Research
Eco-SSLfor Arsenic
                                   66
March 2005

-------
                46(1/5): 559-561.

Mix            Kaalaas, John Atle, Ringsby, Thor Harald, and Lierhagen, Syverin.  1995.  metals and selenium in
                wild animals from norwegian areas close to russian nickel smelters.   Environ. Monit. Assess.
                (1995) Volume Date 1995, 36(3): 251-70.

Orgmet        Kailaswar, S. A., Burte, R. G.,Pawar, S., andToro, V. A. 1997. effect of dietary supplementation
                of roxarsone and livol on the performance of broilers.   Indian Journal of Animal Nutrition  14(4):
                279-280.

Surv           Kalas, JA, Ringsby, TH, and Lierhagen, S. 1995. metals and slenium in wild animals from
                norwegian areas close to nickel smelters.  Environ. Monitoring Assess.  36:  251-270.

Unrel           Kalra, R. A.  1977. pesticides residues - their implications and the job of a residue analyst.
                Pesticides 11(10): 13-17 1977 (17References).

FL             Kamil'dzhanov, A. Kh, Ubaidullaev, R. U., and Akbarov, A. A.  1986. studying the combined
                effect of arsenic trioxide and germanium dioxide during their hygienic standardization in the
                atmospheric air.  Gigiena i Sanitariya. 0 (8). 1986. 82-84.

FL             Kamkin, A. B.  1982. reevaluation of maximum permissible concentrations of arsenic trioxide in
                the environmental air of inhabited Areas.  Gig Sanit (l):6-9,1982

FL             Kamkin, A. B.  review of the maximum permissible concentration of arsenic trioxide in the
                atmosphere of populated places.   Gig Sanit (l):6-9,1982

InVit           Kanti, A. and Smith, M. A.  1997. effects of heavy metals on chondrogenic differentiation of
                embryonic chick limb Cells.  In Vitro Toxicology. 10(3): 329-338.

InVit           Kapahi, P.,Boulton, M. E., andKirkwood, T. B. 1999. positive correlation between mammalian
                life span and cellular resistance to stress.  Free Radical Biology & Medicine  26(5-6):  495-500.

No Oral        Karnofsky, D. A.  1955. assay of chemotherapeutic agents on the developing chick embryo.
                Cancer Res 15(suppl 3): 83-85,1955

Mix            Karunski, A. I., Kryuchkova, E. F., and Nikfturskii, N. I. 1993. wastes from sugarbeet
                production in the feeding of pigs and chickens.   Zootekhniya.(9)\ 15-18.

Acu            Katayama, Masayuki, Sugawa-Katayama, Yohko, and Nakano, Yukihiro. study on arsenic
                metabolism in animals by neutron activation analysis.   Kyoto Daigaku Genshiro Jikkensho
                Gakujutsu Koenkai Hobunshu (1994)  28: 67-72.

Acu            Katayama, Masayuki, Sugawa-Katayama, Yohko, and Otsuki, Kazuko.  1994.  effects of hijiki
                feeding on arsenic distribution in  rats  administered large doses of arsenate.  Appl. Organomet.
                Chem. (1994)  8(3): 259-64.

Acu            Katayama, Masayuki, Sugawa-Katayama, Yohko, and Tamura, Tomoko.  1992.  arsenic
                distribution in  rats  fed a hijiki  diet.  Appl. Organomet. Chem. (1992)  6(4): 389-92.

Acu            Kato, Y., Maki S-I, Matano, O., and Goto, S.  1980. trans placenta! bio accumulation of organo
                arsenate in rat fetal blood after ferric methane arsonate Administration.  J Pestic Sci (Nihon
                Noyakugaku Kaishi).  5 (3).  1980. 427-430.


Eco-SSL for Arsenic                               67                                      March 2005

-------
No Oral        Katsnel'son, B. A., Neizvestnova, Ye. M., and Blokhin, V. A.  1986.  stomach carcinogenesis
                induction by chronic treatment with arsenic.   Vopr. Onkol.  (1986)  32(3): 68-73.

In Vit          Kawasaki, Hiroshi, Moriguchi, Tetsuo, Matsuda, Satoshi, Li, Hong Zen, Nakamura, Shun,
                Shimohama, Shun, Kimura, Jun, Gotoh, Yukiko, and Nishida, Eisuke.  1996.  ras-dependent and
                ras-independent activation pathways for the stress-activated-protein-kinase cascade.  Eur. J.
                Biochem. (1996)  241(2): 315-321.

In Vitro        Keith, R. L., Gandolfi, A. J., Mclntyre, L. C. Jr., Ashbaugh, M. D., and Fernando, Q. 1999.
                analysis of heavy metal deposition in renal tissue by sectional mapping using pixe.  Nucl.
                Instrum. Methods Phys. Res.   Sect. B (1999): 149(1,2), 167-176.

Unrel          Kelley, Timothy R., Pancorbo, Oscar C., Merka, William C., Thompson, Sidney A., Cabrera,
                Miguel L., and Barnhart, Harold M.  1998. accumulation of elements in fractionated broiler litter
                during re-utilization.   J. Appl. Poult. Res.   7(1):  27-34 .

OrgMet        Kennedy, S., Rice, D. A., and Cush, P. F. 1986. neuropathology of experimental 3-nitro-4-
                hydroxyphenylarsonic acidtoxicosis in pigs.   Veterinary Pathology 23(4):  454-461.

Acute          Kenyon, E. M., Hughes, M. F., Del Razo, L. M., Edwards, B. C., Mitchell, C. T., and Levander, O.
                A.  1999. influence of  dietary  selenium on the disposition of arsenate and arsenite in the female
                b6c3fl  mouse.   Environ. Nutr. Interact. (1999)  3(2): 95-113.

Nut def         Kenyon, E. M., Hughes, M. F., and Levander, O. A. 1997.  influence of dietary selenium on the
                disposition of arsenate in the female b6c3fl mouse.  J Toxicol Environ Health. 51(3):  279-99.

Care           Kerkvliet, N. Isaacson and Steppan, L. Baecher. 1980.  immunotoxicology studies of sodium
                arsenate - effects of exposure on tumor growth  and cell-mediated tumor immunity.  J. Environ.
                Pathol. Toxicol. (1980) 4(5-6):  65-79.

Org met        Kerr, KB, Narveson, JR, and Lux, FA. 1969.  toxicity of an organic arsenical, 3-nitro-4-
                hydroxyphenylarsonic acid: residues in chicken tissues.   J. Agr. Food Chem.  17(6): 1400-1402.

Mix            Kienholz, E. W., Ward, G. M., Johnson, D. E., Baxter, J., Braude, G., and Stern, G. 1979.
                metropolitan denver Colorado usa sewage sludge fed to feedlot steers.  Journal of Animal Science.
                48 (4): 735-741.

In Vit          Kim, Y. J., Shuman, J., Sette, M., and Przybyla, A. 1983.  arsenate induces stress proteins in
                cultured rat myoblasts.   Vol. 96, No. 2, Pp. 393-400  J. Cell Biol.

An Prod        Kinabo, L. D. B.  1993. pharmacology of existing drugs for animal trypanosomiasis. Ada
                Tropica  54(3-4): 169-183.

No Oral        King, J. R., Peters, B. P., and Monteiro-riviere, N.  A.  laminin in the cutaneous basement
                membrane as a potential target in lewisite vesication.   Toxicology and Applied Pharmacology.
                126(1). 1994. 164-173.

FL             Kirilenko, A. V.  1975. avitellina arctica in rangifer tarandus.   Veterinariya, Moscow (7):  58-59.

Drug           Kirilenko, A. V.  1975. trials of some anthelmintics for monieziasis in rangifer tarandus.
                Bor'Ba s Boleznyami Sel'Skokhozyaistvennykh Zhivotnykhv Zabaikal'e i Na
                Dal'Nem Vostoke, Vyp.  2.  77-80.
Eco-SSLfor Arsenic
68
March 2005

-------
Acu
Rev
Kitagawa, H., Saito, H., Sugimoto, T., Yanaura, S., Kitagawa, H., Hosokawa, T., and Sakamoto,
K.  1982. effects of diiospropyl-l,3-dithiol-2-ylidene malonate (nkk-105) on acute toxicity of
various drags and heavy metals.   Journal ofToxicological Sciences  7(2): 123-34.

Klaassen, C. D. and Liu, Jie.  1997. role of metallothionein in cadmium-induced hepatotoxicity
and nephrotoxicity: new horizons in chemical-induced liver injury.  DrugMetab. Rev.  29(1-2):
79-102.
Drug
Klakow F-J, Mueller, M, and Jonas, K.  1986. use of magnesium chloride brine in drinking water
for prophylaxis against grass tetany of cattle.  Monatshefte Fuer Veterinaermedizin. 41 (15).
1986. 505-509.
Unrel
BioX
CP
InVit
Klee, S. R., Tzschaschel, B. D., Fait, I., Karnell, A., Lindberg, A. A., Timmis, K. N., and Guzman,
C. A.  1997.  construction and characterization of a live attenuated vaccine candidate against
shigella dysenteriae type 1.  Infection and Immunity  65(6): 2112-8.

Klee, S. R., Tzschaschel, B. D., Singh, M., Fait, I., Lindberg, A. A., Timmis, K. N., and Guzman,
C. A. 1997. construction and characterization of genetically -marked bivalent anti-shigella
dysenteriae 1  and anti-shigella flexneri y live vaccine candidates.  Microbial Pathogenesis
22(6): 363-76.

Kluge-Berge, S.,  Ingkaninun, P., and Poomvises, P.  1993.  residues of potentially
harmful substances in norwegian slaughteranimals.    Proceedings,  llth
International  Symposium of the WorldAssociation of Veterinary Food Hygienists, 24-29 October
1993, Bangkokjhailand.  471-474.
Knapp, F. F.
1980
1981.Nuclear Medicine Technology Progress Report for Quarter Ending June 30,
Unrel
Meth
Method
Surv
Phys
FL
FL
Knapp, F. F. Jr. 1981. nuclear medicine technology, progress report, quarter ending march 31,
1980.  Govt Reports Announcements & Index (GRA&I)

Kobayashi, Yoshinori. 1989. development of an x-ray fluorescence element mapping
spectrometer and its application to biological samples.  Kagaku Gijutsu Kenkyusho Hokoku
(1989) 84(12): 643-54.

Kogure,  K. and Alonso, O. F. 1978. a pictorial representation of endogenous brain atp by a
bio luminescent method.  Brain Research  154(2):  273-84.

Kohiyama Masatake, Kanematsu Hiromu, and Niiya Isao.  1992.  studies on the behavior of trace
components in oils and fats during processing for edible use: iv. decrease of trace metals in oils
and fats during deacidifying, bleaching and deodorizing.  Journal of the Japan Oil Chemists'
Society  41(12):  1180-1184.

Koizumi, T., Yamauchi, R., Irie, A., Negishi, M., andlchikawa, A.  1991.  induction of a 31,000-
dalton stress protein by prostaglandins d2 and J2 in porcine aortic endothelial cells.   Biochemical
Pharmacology  42(4): 777-85.

Kojima,  H. studies on developmental pharmacology of arsenite part 2 effect of arsenite on
pregnancy nutrition and hard tissue..  Folia Pharmacologica Japonica. 70(2).  1974  149-163

Kojima, H. 1974. [developmental pharmacology of arsenic. 2. effect of arsenic on pregnancy,
Eco-SSLfor Arsenic
                                   69
                                                               March 2005

-------
                nutritional state and hard tissue].   Nippon Yakurigaku Zasshi  70(2):  149-63.

BioAcc         Kollmer, W. E. arsenic in induced hair of the  rat  and its relation to the content in various organs
                during chronic exposure.  J. Trace Elem. Electrolytes Health Dis. (1992)  6(1): 11-14.

Acu            Kollmer, W. E. the dose response of arsenic in induced hair of the  rat and its relation to the
                content in various organs following acute exposure.  J. Trace Elem. Electrolytes Health Dis.
                (1990)  4(2): 79-85

Acute          Kondo, M and Ichikawa, I.  1999.  acute effects of orally administered sodium arsenate on heme
                biosynthetic enzymes in the tissues of three strains of mice.  Applied Organometallic Chem.  13:
                649-654.
Acute
Acu
FL
Abstract
FL
FL
Unrel
Kondo, Masao and Ichikawa, Isamu. 1999. acute effects of orally administered sodium arsenate
on heme biosynthetic enzymes in the tissues of three strains of  mice.  Appl. Organomet. Chem.
(1999)  13(9): 649-654 .

Kondo, Masao and Ichikawa, Isamu. 1994. different acute effects of oral and intratracheal
administration of disodium arsenate and gallium arsenide on heme synthesis in  rats.  Appl.
Organomet. Chem. (1994)  8(3): 215-21.

Kopbosynov, B.  1976. prophylaxis of anoplocephalata infections in sheep.  Veterinariya,
Moscow (6): 60-61.

Koropatnick Jim(A), Pearson-Sharpe Jane, and Fisman Michael. 1994. arsenic treatment induces
accumulation of proteins derived from amyloid precursor protein (app) in rat liver and brain.
Neurobiology of Aging 15(SUPPL. 1):  S66.

Koshkina, N. G., Logachev, E. D., and Tishchenko, L. G.  1978. fine morphology of the genital
organs of moniezia when normal andaction of some anthelmintics.  Trudy Kazakhskogo
Nauchno-Issledovatel'Skogo Veterinarnogo Instituta (Voprosy Veterinarnoi Parazitologii v
Kazakhstane)  17: 100-102.

Kozlov, V. L, Pugachev, M. K.,  and Terman, O. A. 1990. [direct action of low-intensity laser
irradiation on the morphofunctional status of the zona fasciculata of the adrenal cortex of white
rats].   napravlennoe vozdeistvie nizkointensivnogo lazernogo izlucheniia na
morfofunktsional'noe sostoianie  puchkovoi zony kory nadpochechnikov u beloi krysy.  Biulleten'
Eksperimental'Noi Biologii i Meditsiny  109(6): 598-600.

Kradel, J. 1971.  (the environment and plant protection.).   Prakt. Schaedlingsbekaempfer;  23(5):
64-9  1971
FL             Krasovskii, G. N. and Pozhidaeva, N. V.  1984.  [comparative toxicity of inorganic compounds
                containing 3- and 5-valent arsenic with respect to health standards for water]. 
                sravnitel'naia toksichnost' neorganicheskikh soedinenii, soderzhashchikh trekh- i piativalentnyi
                mysh'iak, v sviazi s ikh gigienicheskim reglamentirovaniem v vode.  Gigiena i Sanitariia (4): 9-
                11.

No Oral         Kraus, R. J. and Ganther, H. E.  1989.  synergistic toxicity between arsenic and methylated
                selenium compounds.  Biol Trace Elem Res.  20(1-2):  105-114.

FL             Krause, U and Anke, M.  1988. (arsenic intake by man and animals).  Zent. Bl. Pharm.
Eco-SSLfor Arsenic
                                   70
March 2005

-------
                Pharmakother. Lab. Diagn.  127:  363-364.

No Oral        Kreppel, H.  1993. metallothionein and arsenic toxicity.  Met.-Met. Interact. [Symp.J :  129-48.
                Editor(s): Elsenhans, Bernd; Forth, Wolfgang; Schuemann, Klaus. Publisher: Bertelsmann Found.
                Publ., Guetersloh, Germany..

Acu            Kreppel, H., Kolb, K., Reichl, F. X., Fichtl, B., and Forth, W.  1988. pretreatment with low doses
                of cadmium or zinc decreases  lethality  in  mice  acutely poisoned with arsenic.  Trace Elem.
                Anal. Chem. Med. Biol.  Proc. Int. Workshop, 5th (1988): 594-600.  Editor(s): Braetter, Peter;
                Schramel, Peter. Publisher: de Gruyter, Berlin, Fed. Rep. Ger.

No Oral        Kreppel, Helmut, Liu, Jie, Liu, Yaping, Reichl, Franz Xaver, and Klaassen, Curtis D.  1994. zinc-
                induced arsenite tolerance in mice.  Fundam. Appl. Toxicol. (1994)  23(1):  32-7.

No Oral        Kreppel, Helmut, Paepcke, Uwe, Thiermann, Horst, Szinicz, Ladislaus, Reichl, Franz X.,  Singh,
                Pramod K., and Jones, Mark M. 1993. therapeutic efficacy of new dimercaptosuccinic acid
                (dmsa) analogs in acute arsenic trioxide poisoning in mice.  Arch. Toxicol. (1993)  67(8): 580-5


No Oral        Kreppel, Helmut, Reichl,  Franz X., Kleine, Andreas, Szinicz, Ladislaus, Singh, Pramod K., and
                Jones, Mark M. 1995. antidotal efficacy of newly synthesized dimercaptosuccinic acid (dmsa)
                monoesters in experimental arsenic poisoning in mice.  Fundam. Appl. Toxicol. (1995)  26(2):
                239-45

No Dose        Kruckenberg, S. M., Cook, J. E., and Feldman, B. F.  1975.  clinical toxicities of pet and caged
                rodents and rabbits.   Vet.  Clin. N. Am. 5(4): 675-684; 1975.

Surv           LaDelfe, C. M. IV&l.Detailed Geochemical Survey Data Release for the San Andres-Oscura
                Mountains Special Study Area, New Mexico.  GJBX-215-81; LA-8016-MS

Surv           Lagally, H. R., Biddle, G.  N., and Siewicki, T. C.  1980.Cadmium Retention in Rats Fed Either
                Bound Cadmium in Scallops or Cadmium Sulfate

Surv           Lagally, H. R., Biddle, G.  N., and Siewicki, T. C. 1980. cadmium retention in rats fed bound
                cadmium in scallops or cadmium sulfate.  NutrRepInt. 21(3): 351-364.

HHE           Lagerkvist, B. E. and Linderholm, H.  1986.  cold hands after exposure to arsenic or vibrating
                tools - effects of ketanserin on finger blood-pressure and skin temperature.  A eta Pharmacologica
                Et Toxicologica  58(5): 327-332.

Bio Ace         Lakso, JU and Peoples,  SA.  1975. methylation of inorganic arsenic by mammals.  J.Agric.
                Food Chem. 23(4):  674-676.

Unrel           Lambert, H., Charette, S. J., Bernier, A. F., Guimond, A., and Landry, J. 1999. hsp27
                multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino
                terminus.  Journal of Biological Chemistry  274(14):  9378-85.

InVit           Landry, J. and Chretien, P. 1983.  relationship between hyper thermia induced heat shock proteins
                and thermo tolerance in morris hepatoma cells.. Canadian Journal of Biochemistry and Cell
                Biology.  61 (6). 1983. 428-437.

Rev            Langlands, J. P., Bowles, J. E., Donald, G. E., and Smith, A. J.  1986. Commonwealth Scientific
Eco-SSLfor Arsenic
71
March 2005

-------
                and Industrial Research Organization Armidale Australia Div. of Animal Production.  1986.
                selenium excretion in sheep.   Australian Journal of Agricultural Research. V. 3 7(2) P. 201-209

Unrel           Lanks, K. W., Kasambalides, E. I, Clunkers, M, and Brugge, J. S. 1982.  a major cytoplasmic
                glucose-regulated protein is associated with the rous sarcoma virus pp60src protein.  Journal of
                Biological Chemistry  257(15):  8604-7.

No Oral        Lappas, G. D., Karl, I. E., and Hotchkiss, R. S. 1994. effect of ethanol and sodium arsenite on
                hsp-72 formation and on survival in a murine endotoxin model.   Shock  2(1):  34-9; discussion
                40.

Carcin         Larsson, Sture, Karlberg, Ingvar, Selin, Eva, Daneryd, Peter, and Peterson, Hans Inge.  1987.
                trace element changes in serum and skeletal muscle compared to tumor tissue in sarcoma-bearing
                rats.  In Vivo (1987)  1(3):  131-40.

In Vit           Laszlo, A. 1988.  the relationship of heat-shock proteins thermotolerance and protein synthesis.
                Experimental Cell Research.  178(2).  1988. 401-414.

Unrel           Laszlo Andrei.  1992.  the thermoresistance state: protection from initial damage or better repair?
                Experimental Cell Research  202(2):  519-531.

Phys           Laszlo Andrei(A) and Li Gloria C.  1993. effect of amino acid analogs on the development of
                thermotolerance and on thermotolerant cells.  Journal of Cellular Physiology  154(2):  419-432.

FL             Laukova, A. 1994. metal ion resistance in rumen staphylococci.  Veterinarni Medicina  39(7):
                389-395.
Unrel
FL
Laukova A(A) and Kmet, V.  1993. metal ion resistance of the bacteriocin producing enterococci.
Asian-Australasian Journal of Animal Sciences  6(3):  441 -445.

Lebedeva, N. V.  1996. population ecotoxicology of Birds.  Doklady Akademii Nauk.  351(3):
425-429.
Org met        Ledet, A. E. and Buck, W. B. AU  F. W. Oehme CS State Univ. toxicity of organic
                arsenicals in feedstuffs.   ^-Document Title>Toxicity of Heavy Metals in the Environment. Part 1

Rev            Ledet, AE and Buck, WB. toxicity of organic arsenicals in feedstuffs.  in Oehme, FW (Ed)
                Toxicity of Heavy Metals in the Environment.  Part 1.: 375-391.

Org met        Ledet, AE, Duncan, JR, Buck, WB, and Ramsey, FK. 1973.  clinical, lexicological, adn
                pathological aspects of arsanilic acid poisoning in swine.  Clin. Toxicol.  6: 439.

In Vit          Lee, T. C., Huang, R. Y., and Jan, K. Y. 1985. sodium arsenite enhances the cytotoxicity,
                clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster
                ovary cells.   Mutation Research   148(1-2): 83-9.

In Vit          Lee, T. C., Kao, S. L., and Yih, L. H.  1991. suppression of sodium arsenite-potentiated
                cytotoxicity of ultraviolet light by cycloheximide in Chinese hamster ovary cells.  Archives of
                Toxicology  65(8): 640-5.

In Vit           Lee, T. C., Lee, K. Cc, Chang, C., and J Wo, W. L. cell cycle dependence of the cytotoxicity and
                clastogenicity of sodium arsenite in Chinese hamster ovary cells.   Bull Inst ZoolAcad Sin
Eco-SSLfor Arsenic
                                   72
March 2005

-------
                (Taipei); 25 (1). 1986. 91-98.

In Vit          Lee, T. C., Oshimura, M, and Barrett, J. C.  1985.  comparison of arsenic-induced cell
                transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in
                culture.   Carcinogenesis  6(10):  1421-6.

In Vit          Lee, Y. J. and Dewey, W. C. 1987. effect of cycloheximide or puromycin on induction of
                thermotolerance by sodium arsenite in Chinese hamster ovary cells: involvement of heat shock
                proteins.  Journal of Cellular Physiology  132(1):  41-8.

Unrel          Lee, Y. J., Perlaky, L., Dewey, W. C., Armour, E. P., and Cony, P. M. 1990. differences in
                thermotolerance induced by heat or sodium arsenite cell killing and inhibition of protein synthesis.
                 RADIATRES. Radiation Research.  121 (3). 1990. 295-303.

Surv            Lehn, P. J.,Pate, B.D., King, D. R.,andVoigt, R. C. 1972. evaluation of the effects of
                defoliants on the animal communities oftest area c-52a, Eglin air force base, Florida.    90.

No Oral        Leikin, J. B., Goldman-Leikin, R. E.,  Evans, M. A., Wiener, S., and Hryhorczuk, D. O.  1991.
                immunotherapy in acute arsenic poisoning.  Journal of Toxicology.  Clinical Toxicology  29(1):
                59-70.

Mix            Levander, L. C. OAArgrett. effects of arsenic, mercury, thallium and lead on selenium
                metabolism in rats.   Toxicol. Appl. Pharmacol.; 14(2)  308-1914.

Rev            Levander, O. A.  1972. metabolic interrelationships and adaptations in selenium toxicity.  Ann N
                YAcadSci.  192:  181-92.

CP             Levander, O. A. and Morris, V. C.  effect of arsenite on the metabolism of excess selenium fed to
                rats  as selenite or high-selenium yeast.  Spurenelem.-Symp.: Arsen 3rd (1980): 69-74.
                Editor(s): Anke, Manfred; Schneider, Hans-Joachim; Brueckner, Chr. Publisher: Friedrich-
                Schiller- Univ. Jena Abt. Wiss. Publ., Jena, Ger. Dem. Rep.

In Vit          Levander, O. A., Morris, V. C, and Higgs, D. J.  1973. acceleration of thiol-induced swelling of
                rat liver mitochondria by selenium.  Biochemistry  12(23): 4586-90.

Mix            Levander, Orville A.  and Argrett, L. C.  1969.  effects of arsenic,  mercury, thallium, and lead on
                selenium metabolism in rats.   Toxicol. Appl. Pharmacol. (1969)  14(2):  308-14.

No Dose        Levkutova, M., Revajova, V., Levkut, M.  1998.  andLeng, L..  1998. subpopulations of
                lymphocytes in cattle naturally infected with papillomavirus.  Acta Veterinaria Hungarica.  V.
                46(1) P. 13-18

No Oral        Lewis, S. C.  1975. acute lethality of selected heavy metals in spontaneously hypertensive rats.
                Toxicology and Applied Pharmacology. 33 (1). 1975 128

No Dose        Li, D., Cutress, T. W., and Li, X.  1996. [an experimental study on effects of arsenic on dental
                fluorosis in rats].   Chung-Hua Yu Fang i Hsueh Tsa Chih  30(6): 354-6.

In Vit          Li, G. C.  1983. induction of thermotolerance and enhanced heat-shock protein-synthesis in
                chinese-hamster fibroblasts by  sodium arsenite and by ethanol.   Journal Of Cellular Physiology
                115(2): 116-122.
Eco-SSL for Arsenic                                73                                       March 2005

-------
InVit          Li, Gloria C.  1983.  induction of thermotolerance and enhanced heat shock protein synthesis in
                Chinese hamster  fibroblasts by sodium arsenite and by ethanol.  J. Cell. Physiol. (1983)
                115(2): 116-22.

In Vit          Li, Gloria C. and Werb, Zena.  1982. correlation between synthesis of heat shock proteins and
                development  of thermotolerance in Chinese  hamster  fibroblasts.   Proc. Natl. Acad. Sci. U. S.
                A. (1982)  79(10):  3218-22.

No Dose        Li, W., Chien, P. K., and Furst, A.  1994. evaluation of three antidotes on arsenic toxicity in the
                common earthworm (Lumbricus terrestris).   Journal of Applied Toxicology  14(3): 181-3.

FL             Li, Y. and Zhu, H.   1997. [a study on the relation between nitric oxide and abnormal development
                of embryos].   Wei Sheng Yen  Chiu 26(3):  162-6.

FL             Li, Yong, Sun, Mianling, Wu,  Desheng, and Chen, Xing.  1999. toxicity of combination of
                selenium, fluoride and arsenic  on rat   embryos.  Weisheng Yanjiu (1999)  28(2): 74-75.

No Oral        Li, Yong, Yu, Zaifang, and Zhu, Huigang.  1998. role of programmed cell death in mediating
                arsenic-induced  rat  embryo anomalies.   Weisheng Yanjiu (1998)  27(2):  91-94.

Sed             Liber K(A) and Sobey S(A). 1999.  toxicity of uranium, nickel and arsenic to hyalella azteca in
                spiked-sediment toxicity tests.   Canadian Technical Report of Fisheries and Aquatic Sciences
                (2293): 107.

Surv           Lipa, J. J. and Trojanowski, H. 1977.   study on the effect of pesticides on the useful microflora
                and fauna of farmlands and gardens in Poland.  Postepy NaukRoln. 24(2): 77-94 1977 (77
                References).

Plant           Liu Donghua(A), Jiang Wusheng(A), and Li Deshen.  1993. effects of aluminium ion on root
                growth, cell division, and nucleoli of garlic (A Ilium sativum /.).  Environmental Pollution  82(3):
                295-299.

In Vit          Liu, Y. signal transduction pathways in response to stress.  Crisp Data Base National Institutes
                OfHealth

Orgmet        Lowry, K. R. and Baker, D. H. 1989.  amelioration  of selenium toxicity by arsenicals and
                cysteine.  JAnimSci. 67(4):  959-65. RefID:  1445

Unrel          Lu, Fung Jou.  1990. fluorescent humic substances and blackfoot disease in taiwan.  Appl.
                Organomet. Chem. (1990)  4(3): 191-5.

Gene           Lu, T. Hong, Pepe, J., Lambrecht, R. W., and Bonkovsky, H. L(A).  1996.  regulation of
                metallothionein gene expression, studies in transfected primary cultures of chick embryo liver
                cells.  Biochimie (Paris)  78(4): 236-244.

Unrel          Luthman, M. and Holmgren, A.  1982.  rat liver thioredoxin and thioredoxin reductase ec-1.6.4.5
                purification and characterization. Biochemistry.  21  (26).  1982 (Reed. 1983). 6628-6633.

Unrel          Luthman, M. and Holmgren, A.  1982.  rat liver thioredoxin and thioredoxin reductase:
                purification and characterization.   Biochemistry  21(26):  6628-33.

Gene           Lynn, S., Lai, H. T., Gurr, J. R., and Jan, K. Y.  1997.  arsenite retards dna break rejoining by
Eco-SSLfor Arsenic
74
March 2005

-------
                inhibiting dna ligation.  Mutagenesis  12(5): 353-8.

FL             Ma, Long, Zhang, Chen, Liu, Wenjie, Wang, Huaixing, and Jiang, Ping.  1994. effects of arsenic
                on the offspring  development  in  mice.   Zhonghua Yufang Yixue Zazhi (1994)  28(1): 20-3
                CODEN: CHYCDW; ISSN: 0253-9624.

No Oral        Machado, A. F., Hovland, D. N. Jr, Pilafas, S., and Collins, M. D. 1999. teratogenic response to
                arsenite during neurulation: relative sensitivities of c57bl/6j and swv/fnn mice and impact of the
                Splotch Allele.   Toxicological Sciences  51(1): 98-107 .

Cp             Machado, A. F., Hovland, D. NJr, Scott, W. I, and Collins, M.  D.  1997.  teratogenic responses to
                cadmium and arsenite relative sensitivity of c57bl-6 and swv mice.   Joint Meeting of the
                Teratology Society Thirty-seventh Annual Meeting and Tenth International Conference of the
                Organization of Teratology Information Services

No Oral        Machado, AF, Hovland, DN Jr, Pilafas, S, and Collins, MD.  1999. teratogenic response to
                arsenite during neurulation: relative sensitivities of c57bl/6j and swv/fnn mice and impact of the
                splotch allela.   Toxicol. Sci.  51(1):  98-107.

Abstract        Machado, AF, Hovland, DN Jr., Scott, WJ, and Collins, MD.  1997.  teratogenic responses to
                cadmium and arsenite: relative sensitivity to c57bl/6 and swv mice.  Teratology.  55(1):  40.

Surv           MacNeil, J. D.,  Patterson, J. R., Salisbury, C. D. C., and Tessaro, S. V. 1990.  an investigation of
                the trace element status of bison in wood buffalonational park and of ranch-raised bison in
                Saskatchewan, Canada.  InternationalJournal of Environmental Analytical Chemistry.  41(3 +4):
                99-104.

No Oral        Macquillan, M. J. and Shipp, E.  1976.  evaluation of chlorpyrifos and chlorpyrifos-methyl for
                control of dermestes-maculatus coleoptera dermestidae on sheep skins.. Journal of Stored
                Products Research.  12(2). 197693-96.

FL             Maehashi, H. 1974. studies on arsenic metabolism .8. effects of polytamin and polypepton in diet
                on absorption, cumulation and excretion of arsenic in rats.   Folia Pharmacologica Japonica  70:
                P89.
FL
Maehashi, Hiroshi. 1997. toxicology of metals with a special emphasis on the biotransformation
of arsenic and metal chelating agents, dmsa and dmps.  Matsumoto Shigaku (1997) 23(3): 145-
153.
Acu            Maehashi, Hiroshi and Yamaguchi, Yuriko. 1983. treatment of arsenic poisoning with heavy
                metal antagonists in mice.  Matsumoto Shigaku (1983)  9(1):  47-51.

Unrel           Mahaffey, K. R.  1977.  mineral concentrations in animal tissues certain aspects of federal drug
                administration regulatory role.  Journal of Animal Science 44 (3): 509-515.

Dup            Mahaffey, K. R., Capar, S. G., Gladen, B. C., and Fowler, B. A. 1981. concurrent exposure to
                lead, cadmium, and arsenic, effects on toxicity and tissue metal concentrations in the rat.  J Lab
                ClinMed. 98(4):  463-481.

Chem Method          Maher, W. A.  1989.  some observations on the determination of total arsenic in
                        biological tissues.  Microchemical Journal  40(1): 132-135.
Eco-SSLfor Arsenic
                                   75
March 2005

-------
No Dose        Maitai, C. K., Kamau, J. A., Gacuhi, D. M, and Njoroge, S. 1975. an outbreak of arsenic and
                toxaphene poisoning in kenyan cattle.  Veterinary Record  96(No.7):  151-152.

Acute          Maitani, T, Saito, N, Abe, M, Uchiyama, S , and Saito, Y.  1987. chemical form-dependent
                induction of hepatic zinc-thionein by arsenic administration and effect of co-administered selenium
                in mice.   Toxicol. Letters. 39(1):  63-70.

Acute          Maitani, Tamio, Saito, Nobuko, Abe, Mayumi, Uchiyama, Sadao, and Saito, Yukio.  1987.
                chemical form-dependent induction of hepatic zinc-thionein by arsenic administration and effect of
                co-administered selenium in  mice.  Toxicol. Lett. (1987)  39(1):  63-70.

Acu            Malishevskaya, A. S., Grudina, L. M., and Laisheva, M. M. 1966. distribution of arsenic and
                mercury in the blood and organs of animals during acute poisoning.   Tr. Kaz. Nauch.-Issled. Vet.
                Inst. (1966): 12,281-4.

Gene           Mandel, H. G., Triester, S. R., and Szapary, D.  1970. interference of barbiturates with pyrimidine
                incorporation.  3.  studies on the mechanism of the amobarbital-orotate relationship.  Biochemical
                Pharmacology  19(6):  1879-92.

CP             Marafante, E., Rade, J., Pietra, R., Sabbioni, E., and Bertolero, F.  1980. metabolic fate of
                inorganic arsenic in laboratory animals.   Spurenelem.-Symp.:  Arsen 3RD : 49-55. Editor(s):
                Anke, Manfred; Schneider, Hans-Joachim; Brueckner, Chr. Publisher: Friedrich-Schiller- Univ.
                Jena Abt. Wiss. Publ., Jena, Ger. Dem. Rep..

Orgmet        Marafante, E. and Vahter, M.  1986. the effect of dietary  and chemically induced methylation
                deficiency on the metabolism of arsenate in the  rabbit.  Ada Pharmacol.  Toxicol. Suppl.  59(7):
                35-8.
Acute
Unrel
Unrel
Mix
Marafante, E., Vahter, M., and Dencker, L.  1984. metabolism of arsenocholine in mice, rats and
rabbits (presence in seafood products).   The Science Of The Total Environment.  Mar 15, 1984.
v. 34  (3) p. 223-240. ill.

Marin-Padilla, M.  1980.  morphogenesis of experimental encephalocele cranioschisis occulta.  J
NEUROLSCI. Journal of the Neurological Sciences.  46(1). 1980.83-100.

Markovits, Andres, Conejeros, Raul, Lopez, Luis, and Lutz, Mariane.  1992.  evaluation of marine
microalga nannochloropsis sp. as a potential dietary  supplement, chemical, nutritional and short
term toxicological evaluation in  rats.  Nutr. Res. (N. Y.) (1992)  12(10):  1273-84.

Marshall, SP, Hay ward, FW, and Meagher, WR.  1963.  effects of feeding arsenic and lead upon
their secretion in milk.  J. Dairy Sci.  46:  580.
HHE           Mascolo, N., Summa, V., and Tateo, F.  1999.  characterization of toxic elements in clays for
                human healing use.  Appl. Clay Sci.   15(5-6): 491-500.

Acu            Mason, R. W. and Edwards, I. R. 1989. acute toxicity of combinations of sodium dichromate,
                sodium arsenate and copper sulfate in the  rat.  Comp. Biochem. Physiol. C:  Comp. Pharmacol.
                Toxicol.   93C(1):  121-5 .

No Oral        Mason, R. W., Edwards, I. R., and Fisher, L. C. 1987. fetotoxicity and teratogenicity of sodium
                dichromate sodium arsenate and copper sulfate in rats.  Proc Univ Otago Med Sch. 65(3): 59-60.
Eco-SSLfor Arsenic
                                   76
March 2005

-------
No Oral        Mason, R. W., Edwards, I. R., and Fisher, L. C. 1989. teratogenicity of combinations of sodium
                dichromate sodium arsenate and copper sulfate in the rat.  Comp Biochem Physiol C Comp
                Pharmacol Toxicol.  93(2): 407-412.

Surv           Mathews N E and Porter W F.   1989. acute arsenic toxication of a free-ranging white-tailed deer
                innewyork.   Journal of Wildlife Diseases  25.  126(1):  132-135.

FL             Matsumoto, N., lijima, S., and Katsunuma, H.  1975.  fetal body burden of chemicals and its effect
                on fetal Growth.   CongenAnom.  15:  245-246.

Abstract        Matsumoto, N., Okino, T., Katsunuma, H., and lijima, S. 1973. effects of na-arsenate on the
                growth and development of fetal Mice.   Teratology. 8:98,1973

FL             Matsumoto, N., Okino, T., Katsunuma, H., and lijima, S. 1974. effect of sodium arsenite on
                growth and development of fetal mice.  ; 13 (3). 1973 (RECD 1974) Congenital Anomalies.
                13(3): 175-176.

Unrel           Mattingly, M. E., Mattingly, J. R. Jr, and Martinez-Carrion, M.  1982.  phosphorus-31 nmr of
                mitochondria! aspartate amino transferase ec-2.6.1.1 the effects of solution ph and ligand binding.
                Journal of Biological Chemistry. 257 (15).  1982. 8872-8878.

Nut def         Maurice, D. V., Jensen, L. S., and Tojo, H.  1979.  comparison offish meal and soybean meal in
                the prevention of fattyliver-hemorrhagic syndrome in caged layers.  Poultry Science 58(4):  864-
                870.

FL             Mayer, Gabor, Csorba, Erzsebet, Dura, Gyula, Vincze, Istvan, Vargha, Laszlo, and Deak,
                Zsuzsanna. 1989. experimental examination of dermal absorption of arsenic.
                Egeszsegtudomany (1989) 33(3-4): 265-74.

Abstract        McDorman, EW, Collins, BW, Moore, T, George, MH, DeAngelo, AB, Mass, MJ, and Allen, JW.
                1989. micronucleus analysis in mice chronically exposed to arsenic in drinking water.  Environ.
                Molecular Mutagenesis. 31(Supp. 29): 39.

Alt             Mcdowell, L. R., Froseth, J. A., and Piper, R. C.  1978.  influence  of arsenic sulfur cadmium
                tellurium silver and selenium on the selenium vitamin e deficiency in the pig.  NUTR REP INT.
                17(1): 19-34.

Abstract        Mcdowell, L. R., Froseth, J. A., Piper, R. C., and Dyer, I. A.  1971.  selenium retention in the pig.
                Journal of Animal Science. 33 (1).  1971 235-236

HHE           McGown, E. L., van Ravenswaay, T., and Dumlao, C. R. 1987. histologic changes in nude mouse
                skin and human skin xenografts following exposure to sulfhydryl reagents: arsenicals.
                Toxicologic Pathology 15(2):  149-56.

FL             Medovar, E. N. and Grigor'eva, V. A. 1973. effect of microsome  fractions on glycolysis in
                skeletal muscles of normal rabbits  and those with dystrophy.   Ukr. Biokhim.  Zh. (1973)  45(4):
                387-92.
FL
Unrel
Merenyuk, G. V. and Burdenko, T. A.  1969.  toxicology of copper-containing pesticides.
Zdravookhranenie (1969)   12(5):  23-6.

Merry, R. H. and Tiller, K.  G.  1986. the effects of contamination of soil with copper, lead and
Eco-SSLfor Arsenic
                                   77
March 2005

-------
                arsenic on the growth and composition of plants, i. effects of season, genotype, soil temperature,
                and fertilizers.  Plant and Soil. 91:  115-128.

Gene           Mertens, F., Urbain, I, and Slaoui, M. 1989. in vivo induction of a/j anti-ars responses with
                different ranges of affinities: correlation between affinity and cria idiotype dominance.
                Molecular Immunology  26(9):  859-64.

FL             Mertin, D., Hanusova, E., Suvegova, K., and Stepanok, V.  1995.  concentration of some trace
                elements in the fur of greenland nutriaduring ontogenesis.  Scientifur  19(4): 277-280.

Mix             Meshkov, N. V. and Gadzhieva, Z. M.  1949-1954.  pathomorphological changes in the peroral
                action of the arsenic - containing pesticies, zinc fluoroarsenate and barium fluoroarsenate.   Vopr.
                Pitaniya; 28(4)

In Vit          Meunier J-C and Dalziel, K.  1978.  kinetic studies of glyceraldehyde 3 phosphate dehydrogenase
                ec-1.2.1.12 from rabbit muscle.  European Journal of Biochemistry. 82(2). 1978483-492.

In Vit          Meunier, J. C. and Dalziel, K.  1978.  kinetic studies of glyceraldehyde-3-phosphate
                dehydrogenase from rabbit muscle.   European Journal of Biochemistry  82(2): 483-92.

Unrel          Miera, F. R., Langhorst,  G., McEllin, S., and Montoya, C.  1984.  Environmental Studies
                Conducted at the Fenton Hill Hot Dry Rock Geothermal Development Site.  LA-9967-MS

Unrel          Miera, F. R. Jr, Langhorst, G., McEllin, S., and Montoya, C.  1984.  environmental studies
                conducted at the fenton hill hot dry rock geothermal development site.   Govt Reports
                Announcements & Index (GRA&I).(Issue 24,)

Surv           Mikkelsen, R. L., Page, A. L., and Bingham, F. T. 1986. geochemistry and health in California:
                recent experiences with selenium.   Trace Subst. Environ. Health (1986) : 20, 413-23 .

Unrel          Miller, J. J. a, Read, B. J., Wentz, D. J., and Heaney, D. J.  1996.  major and trace element content
                of shallow groundwater associated with dryland saline soils in southern alberta.  Water Quality
                Research Journal of Canada.  31(1):  101-117.

Carcin         Milner, John E. 1969. effect of ingested arsenic on methylcholanthrene-induced skin tumors in
                mice.  Arch. Environ. Health (1969) 18(1): 7-11.

Unrel          Mirkes, Philip E. and Little, Sally A.  1998. teratogen-induced cell death in postimplantation
                mouse  embryos: differential tissue sensitivity and hallmarks of apoptosis.  Cell Death Differ.
                (1998)  5(7): 592-600.

In Vit          Mirkes, Philip E a, Doggett, Barbar, and Cornel, Leanne.  1994. induction of a heat shock
                response (hsp 72) in rat embryos exposed to selected chemical teratogens.   Teratology. 49(2):
                135-142.

No oral         Mitchell, RD, Ayala-Fierro, F, and Carter, DE.  2000.  systemic indicators of inorganic arsenic
                toxicity in four animal species.  J. Toxicol Environ Health, Part A.  59(2):  119-134.

Acute          Mitchell Roger D, Ayala-Fierro Felix, and Carter Dean E(A). 2000. systemic indicators of
                inorganic arsenic toxicity in four animal species.  Journal of Toxicology and Environmental
                Health Part A 59(2): 119-134.
Eco-SSL for Arsenic                               78                                       March 2005

-------
Acu
InVit
In Vitro
Mitra, K., Kundu, S. N., and Khuda Bukhsh, A. R.  1999. efficacy of a potentized homoeopathic
drag (arsenicum album-30) in reducing toxic effects produced by arsenic trioxide in mice: ii. on
alterations in body weight, tissue weight and total protein.   Complementary Therapies in
Medicine  7(1): 24-34.

Mivechi, N. F. and Dewey, W. C.  1985. DNA polymerase alpha and beta activities during the
cell cycle and their role in heat radiosensitization in Chinese hamster ovary cells.. Radiation
Research. 103 (3). 1985.  337-350.

Mohelska, H., Bencko, V., Smetana, K., and Hyncica, V. 1980. ultrastractural changes in
hepatocytes of mice exposed to arsenic in drinking water.  Experimented Pathologie  18(5):
275-81.
No Dose        Monies, R. J. 1997. arsenic poisoning in a dairy heifer following contamination of aredundant
                industrial site with a wood tanalising (preserving) compound(copper sulfate, potassium
                dichromate, and arsenic pentoxide).  Cattle Practice  5(4):  307-312.

Nut def         Montessuit, C, Bonjour, JP, and Caverzasio, J.  1994.  pi transport regulation by chicken growth
                plate chondrocytes.  Am. J. Physiol. 267: E24-31.

Bio Ace         Mora, M. A. and Anderson, D. W. 1995. selenium, boron, and heavy metals in birds from the
                mexicali valley baja California mexico.  Bui Environ Contamin Toxicol. 54(2): p!98-206.

Abstract        Morimoto, Hiroshi, Noro, Haranobu, Otaki, Hiroyasu, and Takagi, Hisao.  1978. influence of
                dietary  minerals on their distribution  in broilers.  Nippon Kakin Gakkaishi (1978)  15(6): 296-
                301.

No Dose        Morris, HP, Lang, EP, Morris, HJ, and Grant, RL.  1938 J. Pharmacol. Exp. Ther. 64: 420.

Organic        Morrison, JL.  1969. distribution of arsenic from poultry litter i broiler chickens, soil, and crops.
                J.Agr. FoodChem.  17(6):  1288-1290.

   Coded        Morrison, L. L. and Chavez, E. R. 1983. selenium-arsenic interaction in the weanling pig.
                Canadian Journal of Animal Science  63(1):  239-246.

No Oral        Morrissey, R. E., Fowler, B. A., Harris, M. W., Moorman, M. P., Adkins, B., and Schwetz, B. A.
                1989. effect of arsine on prenatal development of Swiss (cd-1) mice and fischer 344 rats.
                Toxicologist 1989 Feb/Mar;9(l):32

No Oral        Morrissey, Richard E. and Mottet, N. Karle.  1983. arsenic-induced exencephaly in the  mouse
                and associated lesions occurring during neurulation.   Teratology (1983)  28(3): 399-411.

Aquatic         Motas, C. 1970.  pesticides, their effects on animals and man. water pollution aspects.
                OcrotireaNat; 14(1):  21-33; 1970; (REF:41)

FL             Mourek, Jindrich, Trojan, S., Trojanova, M., Prazkova, V., and Jilek, L. 1970.  changes in the
                resistance of central nervous system to anoxia produced by some metabolic substrates and enzyme
                inhibitors during ontogenesis.  Sb. Lek. (1970)  72(11-12):  302-11.

Surv            Moxham, JW and Coup, MR. 1968. arsenic poisoning of cattle and other domestic animals.
                New Zealand Vet J.  16:  161-165.
Eco-SSLfor Arsenic
                                   79
March 2005

-------
FL
Mix
Unrel
Unrel
No Dose
Unrel
FL
FL
FL
FL
FL
FL
FL
Fate
Mravcova, A.  1985. combined effect of arsenic and selenium administered to  mice  in drinking
  water.   Cesk Hyg. (1985)  30(5):  257-68.

Mueller W-U and Streffer, C.  1987. risk to preimplantation mouse embryos of combinations of
heavy metals and radiation.   European Late Effects Project (Eulep) Symposium on Effects after
Combined Exposure to Ionizing Radiation and Chemical Substances Held in Connection with the
Annual Meeting of the European Society for Radiation Biology, Pisa, Italy, September 19, 1986.
Int JRadiat BiolRelat StudPhys Chem Med. 51 (6). 1987. 997-1006.

Mukherjee Paramita, Poddar Sandeep, Talukder Geeta, and Sharma Archana(A).  1999. protection
by black tea extract against chromosome damage induced by two heavy metals in mice.
Pharmaceutical Biology  37(3): 243-247.

Murphy, B. J. and Brosnan, M. E.  1976. subcellular localization of ornithine decarboxylase in
liver of and growth-hormone-treated rats.  BiochemicalJournal 157(1):  33-9.

Mutenda, E. K., Sparkes, M. J., and Dixon, H. B.  1995.  arsenite release on enzymic
transformation of arsonomethyl substrate analogues: a potentially lethal synthesis by glycerol-3-
phosphate dehydrogenase. BiochemicalJournal  310(Pt3): 983-8.

Mylona, Photini V.,  Polidoros, Alexios N., and  Scandalios, John G.  1998.  modulation of
antioxidant responses by arsenic in maize.   Free Radical Biol. Med.  (1998)  25(4/5): 576-585.

Nadeenko, V. G. and Lenchenko, V. G.  1977.  nature of the combined action of small doses of
certain elements-antagonists.   Gig Sanit (8):30-34,1977

Nadeenko, V. G. and Lenchenko, V. G. regularities of the combined action of small doses of
certain antagonistic elements.   Gigiena i Sanitariya. (8). 1977 30-34.

Nadeenko, V. G. and Lenchenko, V. G.  1977.  (on the nature of the combined effects of small
doses of some antagonists).     Gigiena i Sanitariya  No. 8: 30-34.

Nadeenko, V. G., Lenchenko, V. G., Genkina, S. B., and Arkhipenko, T. A. effect of tungsten,
molybdenum, copper and arsenic on the intrauterine development  of the fetus.  Farmakol.
Toksikol. (Moscow)  (1978) 41(5): 620-3.

Nadeenko, V. G., Lenchenko, V. G., Genkina, S. B., and Arkhipenko, T. A.   1978. the influence
of tungsten, molibdenum, copper and arsenic on the intrauterine development of the fetus.
Farmakol Toksikol(moscow) 41:620-623,1978

Nadeenko, V. G., Lenchenko, V. G., Genkina, S. B., and Arkhipenko, T. A. 1978. [effect of
wolfram, molybdenum,  copper and arsenic on intrauterine fetal development]:  vliianie
vol'frama, molibdena, medi i mysh'iaka na vnutriutrobnoe razvitie ploda.  Farmakol Toksikol.
41(5):  620-3.

Nadeenko, V. G., Lenchenko, V. G., and Krasovskii, G. N. 1987.  combined effect of metals
during their intake with  drinking  water.   Gig. Sanit. (1987) (12): 9-12.

Naegle, S. R., Yousef, M. K., and Barton, J. T.  1983.  biokinetics of arsenic-74, cadmium-109,
and lead-203: effects of age,  ambient temperature and previous exposure.   Trace Subst. Environ.
Health (1983) :  17,  344-9.
Eco-SSLfor Arsenic
                                   80
March 2005

-------
No Oral


Rev

Org met


Org met




CP
Diss
Diss
Acu
Nagymajtenyi, L., Selypes, A., and Berencsi, G. 1985. chromosomal-aberrations and fetotoxic
effects of atmospheric arsenic exposure in mice.  Journal Of Applied Toxicology  5(2): 61-63.

 NAS, Subcommittee on Mineral Toxicity Committee on Animal Nutrition. 1980.:  588.

Naveen, P. K., Ananthasubramaniam, C. R., and Devasia, P. A.  1977.  studies on the use of
arsenicals in layer poultry rations.  Indian J. Nutr. Diet.  14(2):  47-51.

Naveen, P. K., Ananthasubramaniam, C. R., and Devasia, P. A. Kerala  1977. Agricultural Univ.
Mannuthy India Coll. of Veterinary and Animal Sciences. Dept. of Nutrition.  1977.  effects of
feeding arsenicals on growth in poultry [chickens, india].   Kerala Journal of Veterinary Science.
V. 8(1) P. 31-36

Nedkova, L. and  Botev, N.  1996.  effects of arsenic supply on the growth, health and
some biochemicalparameters in pheasants (phasianus colhicus mongolicus). <.  Document
Title>The Game and the Man. Proceedings International UnionofGame Biologists 22nd Congress
Sofia, Bulgaria, 4-8 September 1995.  461-467.

NeigerR.D. 1988. effects of chronic dietary inorganic arsenic in dogs. DISS. ABST. INT. PT. B
- SCI. & ENG  VOL. 48, NO. 7:  189 ppA.

Neiger, Regg Darwyn.  1987. effects of chronic dietary  inorganic arsenic in dogs.  Avail.:
Univ. Microfilms Int.  Order No. DA8721915 From: Diss. Abstr. Int. B 1988, 48.  7.  1910.   189
pp.

Neklesova, I. E., Egorova, N. V., and Kudrina, M. A.  1966. fungicidal properties and toxicity
with respect to warm-blooded animals or thioesters of certain acids of trivalent arsenic.  Proc.
Acad. Sci. USSR
No Oral        Newman, J. R. 1980. Effects of Air Emissions on Wildlife Resources.  Air Pollution and
                Acid Rain Rept. No. 1. FWS/OBS-80/40.1

Unrel           Ngu Mary, Moya Elena, and Magan Naresh(A).  1998.  tolerance and uptake of cadmium, arsenic
                and lead by fusarium pathogens of cereals.   International Bio deterioration & Bio degradation
                42(1):  55-62.

Unrel           Nielsen, F. H.  1981.  consideration of trace element requirements for preparation of chemically
                defined media.  The Growth Requirements of Vertebrate Cells in Vitro :  68-81.

Nut Def        Nielsen, F. H.  1990.  new essential trace elements for the life sciences.  Biol Trace Elem Res.
                26-27:  599-611.
Diss
Nielsen, F. H., Myron, D. R., and Uthus, E. O.  1978.  newer trace elements - vanadium (v) and
arsenic (as) deficiency signs and possible metabolic roles.   Trace Elem. Metab. Man Anim. Proc.
Int. Symp., 3rd : Meeting Date 1977, 244-7. Editor(s): Kirchgessner, M. Publisher: Arbeitskreis
Tierernaehrungsforschung Weihenstephan Inst. Ernaehrungsphysiol., Freising-Weihenstephan,
Ger.
Abstract        Nielsen, FH, Givand, SH, and Myron, DR. evidence of a possible requirement for arsenic by the
                rat.  Fed. Proc.  34:  923.
Rev
Nielsen, Forrest H., Hunt, Curtiss D., and Uthus, Eric O.  1980. interactions between essential
Eco-SSLfor Arsenic
                                   81
March 2005

-------
                trace andultratrace elements.  Ann. N. Y. Acad. Sci. (1980)  355(Micronutr. Interact.: Vitam.,
                Miner., Hazard. Elem.):  152-647

HHE           Nishino, Y. Shimane Univ. Matsue Japan Faculty of Agriculture, Bairinji, M, Tanikawa, M.,
                Takahashi, A., Nakao, T., and Tanaka, C.  1992. effect of wood treated with wood preservatives
                on living body.  Bulletin of the Faculty of Agriculture - Shimane University.  (No.26) P. 91-95

An Prod        Niven, D. R. and Pritchard, D. A.  1985. effects of control of the sheep body louse (Damalinia
                ovis) on woolproduction and quality.  Australian Journal of Experimental Agriculture  25(1):
                27-31.

Surv           Norheim,  G., Skaare, J. U., and Wiig, O.  1992. some heavy metals, essential elements, and
                chlorinated hydrocarbons in polar bear (Ursus maritimus) at Svalbard.  Environ Pollut.  77(1):
                51-57.

Phys           Nosek, T. M., Leal-Cardoso, J. H., Mclaughlin, M., and Godt, R. E. 1990.  inhibitory influence of
                phosphate and arsenate on contraction of skinned skeletal and cardiac muscle.. American Journal
                of Physiology. 259 (6 Part 1). 1990. C933-C939.

In Vit          Novgorodov, S. A., Kultayeva, E. V., Yaguzhinsky, L. S., and Lemeshko, V. V.   1987. ion
                permeability induction by the sh cross-linking reagents in rat liver mitochondria is inhibited by the
                free radical scavenger butylhydroxytoluene.   Journal ofBioenergetics andBiomembranes.  19
                (3). 1987.  191-202.

FL             Novikov,  Yu. V., Plitman, S. L, Levin, A. L, Shniger, N. Kh., Ershova, T. N., Kagirov, V. N.,
                Tsareva, L. G., Kochetkova, T. A., Lastochkina, K. O., Tyuleneva, I. S., and Noarov, Yu. A.
                1980. health status of the population in relation to use of soft drinkingwater low in minerals.
                Gigiena i  Sanitariya (12): 3-6.

FL             Nozaki, S. 1973.  studies on the arsenic metabolism part 7 added arsenite in diet and resulting
                content in each organ as well as the effect on Diet.   Folia Pharmacol JAP.  69 (1).  1973 201-212

FL             Nozaki, S. 1973.  [arsenic metabolism. 7. relation of arsenite in the diet of arsenic content of
                different organs, with different diets].  Nippon Yakurigaku Zasshi  69(1): 201-12.

FL             Nozaki, S. 1974.  [arsenic metabolism, (ii). arsenic content in the diet and increase in arsenic
                levels in various organs].   Nippon Yakurigaku Zasshi  70(5): 707-18.

FL             Nozaki, Shigeru. 1972.   arsenic metabolism, vi.  effect of components of milk on arsenic
                tolerance in the digestive tract.  Nippon Yakurigaku Zasshi (1972)  68(6): 857-68.

Surv           Nyholm, Erik. 1986. uptake and effects of metals on  birds  and mammals in heavy metal
                contaminated areas.    Inst. Vatten- Luftvaardsforsk. [Publ] B    IVL B 820,  50 pp.

Mix            Nyholm, N. E. I. Umea University Umea Sweden, influence of heavy metal exposure during
                different phases of the.   Arch Environ Contam Toxicol.  V35, N4, P632(6)

Surv           Nyholm, N. El. 1998. influence of heavy metal exposure during different phases of the ontogeny
                on the development of pied flycatchers, ficedula hypoleuca, in natural populations.  Arch Environ
                Contamin Toxicol.  35(4):  p632-637.

Drug           O'brien Dermot J(A). 1999. treatment of psoroptic mange with reference to epidemiology and


Eco-SSL for Arsenic                               82                                        March 2005

-------
FL
InVit
InVit
Bio Ace
Drug
history.  Veterinary Parasitology  83(3-4):  177-185.

Ochi, T., Kaise, T., and Oya-Ohta, Y. 1994.  glutathione plays different roles in the induction of
the cytotoxic effects of inorganic and organic arsenic compounds in cultured balb/c 3t3 cells.
Experientia  50(2):  115-20.

Ochi, T., Nakajima, F., Shimizu, A., and Harada, M.  1999. induction of multinucleated cells in
v79 Chinese hamster cells exposed to dimethylarsinic acid, a methylated derivative of inorganic
arsenics: mechanism associated with the formation of aberrant mitotic spindles.   Vol.  13, No. 1,
Pp. 11-25 Toxicology In Vitro

Ochi, Takafumi, Nakajima, Fumie, and Fukumori, Nobutaka.  1998. different effects of inorganic
and dimethylated arsenic compounds on cell  morphology, cytoskeletal organization, and dna
synthesis in cultured Chinese  hamster  v79 cells.   Arch. Toxicol.  (1998)  72(9): 566-573.

Odanaka, Y, Matano, O, and Goto, S. 1980.  biomethylation of inorganic arsenic by the rat and
some laboratory animals.   Bull. Environ. Contain. Toxicol. 24: 452-459.

Odunuga, O. O., Okunade, G. W., and Olorunsogo, O. O. 1999. reversal of sodium arsenite
inhibition of rat liver microsomal ca2+ pumping atpase by vitamin c.  Bioscience Reports  19(1):
11-5.
Surv
Ohlendorf, Harry M., Hothem, Roger L., Aldrich, Thomas W., and Krynitsky, Alexander J. 1987.
selenium contamination of the grasslands, a major California waterfowl area.   Sci. Total Environ.
66, 169-83.
Nut def         Ohmori, S. and Takagi, Y. 1991. elemental concentrations in hair of protein malnourished rats
                and zinc deficient  rats.  Biomed. Res. Trace Elem.  2(2):  203-4.

No Dose         Ohtsuka, K., Nakamura, H., and Sato, C.  1986.  intracellular distribution of 73,000 and 72,000
                dalton heat shock proteins in hela cells.  International Journal ofHyperthermia  2(3):  267-75.

Unrel           Ohtsuka K(A), Liu Y-C, and Kaneda, T. 1993.  cytoskeletal thermotolerance in nrk cells.
                InternationalJournalofHyperthermia  9(1):  115-124.

HHE           Okui, T. and Fujiwara, Y.  1986.  inhibition of human excision dna repair by inorganic arsenic and
                the co-mutagenic effect in v79 Chinese hamster cells.  Mutation Research  172(1): 69-76.

In Vit           Okui, Toyo.  1987. cytotoxicity and effects of arsenic compounds on dna repair in cho cells.
                Eisei Kagaku (1987)  33(1): 20-4.

HHE           Okui, Toyo and Fujiwara, Yoshisada. inhibition of human excision dna repair by inorganic arsenic
                and the  co-mutagenic effect in v-79 Chinese  hamster  cells.  Mutat. Res. (1986)  172(1):  69-76
                CODEN: MUREAV; ISSN: 0027-5107.

Aquatic         Oleson  S.G. and Carr J.R.  1990. correspondence analysis of water quality data: implications for
                fauna deaths at stillwater lakes, nevada.  Math. Geol  VOL. 22, NO. 6: pp. 665-698.

No Oral         Omura, M., Tanaka, A., Hirata, M., Zhao, M., Makita, Y., Inoue, N., Gotoh, K., and Ishinishi, N.
                1996.  testicular toxicity of gallium arsenide, indium arsenide, and arsenic oxide in rats by
                repetitive intratracheal Instillation.   Fundamental and Applied Toxicology;  32 (1). 1996. 72-78.
Eco-SSLfor Arsenic
                                   83
March 2005

-------
No Oral
Fate
Omura Minoru(A), Hirata Miyuki, Tanaka Akiyo, Zhao Mangen, Makita Yuji, Inoue Noahide,
Gotoh Kaoru, and Ishinishi Noburu. 1996. testicular toxicity evaluation of arsenic-containing
binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters.
Toxicology Letters (Shannon)  89(2):  123-129.

Ong, Colin G. and Tanji, Kenneth K. 1993. evaporative concentration of trace elements in a
multicell agricultural evaporation pond.  J. Agric. Food Chem. (1993)  41(9): 1507-10 CODEN:
JAFCAU; ISSN: 0021-8561.
In Vit          Opanashuk, L. A. and Finkelstein, J. N.  1995. relationship of lead-induced proteins to stress
                response proteins in astroglial cells.  Journal of Neuroscience Research 42(5):  623-32.

FL             Orlova AkinchevaMYa, N. V. 1967. hygienic characterizations of certain arsenic-containing
                pesticides.   Vop. Pitaniya; 26(1): 63-9

Bio Ace         Osowski, S. L., Brewer, L. W., Baker, O. E., and Cobb, G. P.  1995.  the decline of mink in
                georgia, north Carolina, and south Carolina: the role of contaminants.   Arch Environ Contain
                Toxicol. 29(3): 418-23.

In Vit          Ovelgonne Hans H, Wiegant Fred A, Souren Jan E M, Van Rijn Han, and Van Wijk Roeland.
                1995. enhancement of the stress response by low concentrations of arsenite in arsenite-pretreated
                reuber h35 hepatoma cells.  Toxicology and Applied Pharmacology  132(1): 146-155.

Lead Shot      Pain, D. J., Amiard-Triquet, C., and Sylvestre, C. 1992. tissue lead concentrations and shot
                ingestion in nine species of waterbirds from the camargue (france).   Ecotoxicol Environ Saf.
                24(2):  217-33.

Unrel          Pain, D. I, Sanchez, A., andMeharg, A. A. 1998.  the donana ecological disaster: contamination
                of a world heritage estuarine marsh ecosystem with acidified pyrite mine waste.   Sci. Total
                Environ. (1998)  222(1,2): 45-54.

No Oral        Palmer, I. S., Arnold, R. L., and Carlson, C. W.  1973. toxicity of various selenium derivatives to
                chick Embryos.  Poult Sci.  52:  1841-1846.

HHE           Papp, J. P., Gay, P. C., Dodson, V N., and Pollard, H. M.  119-1923.  potassium chloride
                treatment in thallotoxicosis.   Ann. Internal Med.; 71(1)

Acu            Paramita Mukherjee,  Sandeep Poddar, Geeta Talukder, and Archana Sharma.  1999.  protection by
                black tea extract against chromosome damage induced bytwo heavy metals in mice.
                Pharmaceutical Biology   37(3):  243-247.

CP             Park, J. H(A), Chung, H. J., Kim, Y. O., Chung,  S. T., Kim, J. H., Han, S. S., and Cho, D. H.
                1999. hematopoietic  effects in mice exposed to sodium arsenite.  FASEB Journal  13(4 PART
                1): A358.

In Vit          Paschin, Y. V, Kozachenko, V L,  andToropzev, S. N.  1983.  suppression by arsenic trioxide of
                the induction of mutations in the mouse  bone marrow and male germ cells by an alkylating agent.
                 Int. J. Environ. Stud. (1983) 21(3-4): 317-24.

Surv           Pascoe, GA, Blanchet, RJ, and Linder, G.  1994. bioavailability of metals and arsenic to small
                mammals at a mining waste-contaminated wetland .  Arch. Environ. Contam. Toxicol.  27:  44-
                50.
Eco-SSLfor Arsenic
                                   84
March 2005

-------
InVit
InVit
Pashin, I. u. V., Kozachenko, V. L, and Toroptsev, S. N.  1984.  [arsenic trioxide inhibition of the
thiophosphamide induction of mutations in mouse germ and somatic cells]. 
ingibirovanie trioksidom mysh'iaka induktsii mutatsii tiofosfamidom v polovykh i somaticheskikh
kletkakh myshi.   Genetika  20(2):  365-6.

Pashin, Y. U. V, Kozachenko, V. L, and Toroptsev, S. N. inhibition by arsenic trioxide of
induction of mutations with thiotepa in mouse somatic and germ cells.   Genetika; 20 (2). 1984.
365-366.
Gene
Pashin, Yu. V., Kozachenko, V. L, and Toroptsev, S. N. 1984.  inhibition by arsenic trioxide of
the induction of mutations with thiophosphanide in mouse  somatic and germ cells.   Genetika
(Moscow) (1984)  20(2): 365-6.
NoCOC
Chem Meth
Bio Ace
Surv
Bio Ace
CP
Paternain, J. L. Univ of Barcelona Reus Spain, Ortega, A., Domingo, J. L., Llobet, J. M, and
Corbella, J.  oral meso-2,3-dimercaptosuccinic acid in pregnant sprague-dawley rats.   J Toxicol
Environ Health. V30, N3, P191(7)

Peisach, M., Pineda, C. A., Casimiro, E., Gulumian, M., and Pillay, A. E. 1993.  studies by pixe
on the removal of trace metals from the heart, liver and kidneys of the  rat  by chelating agents.
Nucl. Instmm. Methods Phys. Res. Sect. B   B75(l-4):  191-4.

Peles, J. D. and Barrett, G. W. 1997. assessment of metal uptake and genetic damage in small
mammals.   Bull Environ Contain Toxicol.  59(2): 279(6).

Peles, J. D. Savannah River Ecology Laboratory Aiken SC and Barrett, G. W. University of
Georgia Athens, assessment of metal uptake and genetic damage in small mammals.   Bull
Environ Contam Toxicol.  V59, N2, P2 79(6)

Pendleton, Grey W., Whitworth, Molly R., and Olsen, Glenn H.  1995.  accumulation and loss of
arsenic and boron, alone and in combination, in mallard   ducks.   Environ. Toxicol.  Chem.
(1995)  14(8): 1357-64.

Peoples, S. A. the mechanisms of action of arsenicals in feed on performance and health of
Animals.  National Academy of Sciences.  National Academy of Sciences. National Research
Council Publication. No. 1679. The Use of Drugs in Animal Feeds.  Proceedings of a Symposium.
Viii + 407p. Illus. National Academy of Sciences: Washington, D.c. U.S.a. 1969 77-86
Unrel
Peoples, S. A. Jr.  1970.  the pharmacology of rodenticides.
15-8.
Proc. Vertebrate Pest; Conf. No. 4.
InVit
Unrel
Rev

No Oral
Perlaky, L., Lee, Y., and Dewey, W. C.  1991.  heat-induced morphological alterations in non-
tolerant and thermotolerant cells.   International Journal of Radiation Biology  60(5): 819-32.

Pernfuss, B., Ebner, C., Pumpel, T., Diels, L., Macaskie, L., Tsezos, M., Keszthelyi, Z., and
Glombitza, F.  1999.  the" behavior " of five metal biosorbing and bioprecipitating bacterial
strains, inoculated in a moving-bed sand filter.  Process Metall. (1999)  9B(Biohydrometallurgy
and the Environment Toward the Mining of the 21st Century, Pt. B): 373-382..

Pershagen, G. and Vahter, M.  1979.

Peterkova, R. and Puzanova, L.  1976.  effect of trivalent and pentavalent arsenic on early
developmental stages of the chick embryo.  Folia Morphol(prague) 24:5-13,1976
Eco-SSLfor Arsenic
                                   85
                     March 2005

-------
InVit
Chem Meth
No Oral
FL
Acute
Care
Unrel
Unrel
Pfeifer, F. and Schacht, S.  development  and validation of genotoxicological and ecotoxicological
tests for evaluating soil retention.  Forschungsverbund: Biol. Verfahren Bodensaniemng (1998) :
A76-A85 Publisher: Umweltbundesamt, Berlin, Germany..

Pietra, R., Sabbioni, E., and Marafante, E. 1981.  comparative metallobiochemical studies on
present environmental levels of arsenic in mammals, i.  neutron activation analysis of nanogram
levels of arsenic in tissues of laboratory animals.   J. Radioanal.  Chem. (1981)  62(1-2): 41-52

Pipkin, J. L Jr, Anson, J. F., Hinson, W. G., Duffy, P. H., Burns, E. R., and Casciano, D. A.  1987.
the turnover of radiolabeled nuclear proteins in rats exposed to environmental and chemical stress.
 ToxicolLett (AMST); 39 (1). 1987. 15-26.

Plitman, S. L, Novikov, I. u. V., Tulakina, N. V., Mete'lskaia, G.  N., Kochetkova, T. A., and
Khvastunov, R. M.  1989.  [problem of correction of hygienic standards with special reference to
the hardness of drinking water].   k voprosu korrektirovki gigienicheskikh normativov s
uchetom urovnia zhestkosti pi'tevykh vod.  Gigiena i Sanitariia (7): 7-10.

Poma, K., Degraeve, N., and Susanne, C. 1987. cytogenetic effects in  mice  after chronic
exposure to arsenic followed by a single dose of ethyl methanesulfonate.  Cytologia (1987)
52(3):  445-9.

Pories, W. J., Mansour, E. G., and Strain, W. H. 1972.  trace elements that act to inhibit neoplastic
growth.  Annals of the New York Academy of Sciences  199: 265-73.

 Prall, R. C.  the physician's role in prevention of mental and emotional disorders.   Pa. Med.; 75:
71-78; 1972; (REF:40)

Pratap Singh,  Agrawal, O. P., and Shashi Dhawan.  1991. insect pests of different art
and cultural materials and their control.    54-65.
Bio Ace         Prestrud, P., Norheim, G., Sivertsen, T., andDaae, H. L. 1994. levels of toxic and essential
                elements in arctic fox in svalbard.   Polar Biology.  14(3):  155-159.

Bio Ace          Prestrud P(A), Norheim, G., Sivertsen, T., andDaae, H. L.  1994.  levels of toxic and essential
                elements in arctic fox in svalbard.   Polar Biology  14(3):  155-159.

Acu            Pribyl, E. 1927. nitrogen metabolism in experimental subacute arsenic and antimony poisoning.
                J. Biol. Chem. 74: 775.

Rev            Pritsos, C. A.  National Technical Information Service (NTIS).  environmental transformation,
                exposure & effects of pesticide residues.   FEDRIP DATABASE

Bio Ace         Prouty, R. M., Pattee, O. H., and Schmeling, S. K. 1982. ddt poisoning in a cooper's hawk
                collected in 1980.   Vol. 28, No. 3, Pp.  319-321  Bull. Environ. Contam. Toxicol.

Acu            Pryor, G. T., Uyeno, E. T., Tilson, H. A., and Mitchell, C. L. 1983. assessment of chemicals
                using a battery of neurobehavioral tests: a comparative study.  Neurobehavioral  Toxicology and
                Teratology  5(1): 91-117.

No Oral        Puzanova, L.  1980. teratogenic effect of different toxic elements on young chick embryos.
                FoliaMorphol. 28: 354-356.
Eco-SSLfor Arsenic
                                   86
March 2005

-------
No Oral        Puzanova, L. 1983. effect of lithium on the developing  chicken  embryo.  Spurenelem.-Symp.
                4th (Issue Lithium,):  295-9.  Editor(s): Anke, Manfred. Publisher: Friedrich-Schiller-Univ., Jena,
                Ger. Dem. Rep.

No COC        Puzanova, L. and Doskocil, M. 1979. teratogenic effect of lithium salts on young chick embryos.
                FoliaMorphol(prague)   27:  26-30.

Plant           Qian, JH, Zayed A,  Zhu, YL, Yu, M, and Terry, N.  1999.  phytoaccumulation of trace elements
                by wetland plants: iii.  uptake and accumulation often trace elements by twelve plant species.  J.
                Environ. Qulaity. 28:  1448-1455.

Plant           Qian, Jin-Hong, Zayed, Adel, Zhu, Yong-Liang, Yu, Mei, and Terry, Norman.  1999.
                phytoaccumulation of trace elements by wetland plants: iii. uptake and accumulation of ten trace
                elements by twelve plant species.  J. Environ. Qual.  (1999)  28(5):  1448-1455.

Unrel           Quin, J. L, Rimington, C., and Roets, G. C.  S. 463-478. studies on the photosensitisation of
                animals in south africa. viii. the biological formation of phylloerythrin in the digestive tracts of
                various domesticated animals.  Onderstepoort J Vet Sci An Indust

Fate            Quinn, T. L. and Ondov, J. M.  1998. influence of temporal changes in relative humidity on dry
                deposition velocities and fluxes of aerosol particles bearing trace elements.  Atmos. Environ.
                (1998)  32(20):  3467-3479.

Invert          Ramos-Morales, P and Rodriguez-Arnaiz, R.  1995.  genotoxicity of two arsenic compounds in
                germ  cells and somatic cells of drosophila melanogaster. Environ. Molec. Mutagenesis. 25(4):
                288-299.

Mix            Rao, Ghanta N. and Knapka, Joseph J.  contaminant and nutrient concentrations of natural
                ingredient  rat  and  mouse   diet  used in chemical toxicology studies.  Fundam. Appl.
                Toxicol. (1987)  9(2):  329-38.

Nutrition       Rao, GN and Knapka, JJ. 1987. contaminant and nutrient concentrations of natural ingredient rat
                and mouse diet used in chemical toxicolgy studies.  Fund. Appl. Toxicol.  9(2):  329-338.

No Oral        Rasco, J. F. and Hood, R. D.  1994. effects of maternal restraint stress and sodium arsenate in
                mice.   Reproductive Toxicology 8(1):  49-54.

Diss            Rasco, Jane Fraser.  1993.  enhancement of the  developmental  toxicity of sodium arsenate and
                all-trans-retinoic acid by maternal restraint stress in  mice.   Avail.: Univ. Microfilms Int. Order
                No. DA9417155 From: Diss. Abstr. Int. B 1994, 55.  2.  258.   129 pp.

Surv            Reece, R. L., Beddome, V. D., and Barr, D. A. 1985. diseases diagnosed in broiler chicken flocks
                in victoria, australia, 1977 to 1984.   Veterinary Record. 116(12):  315-20.

Acu            Reichl, F. X., Kreppel, H., Szinicz, L., Fichtl, B.,  and Forth, W.  1989. effect of glucose in mice
                after acute experimental  poisoning withas203.    1025-1031.

CP             Reichl, F. X., Szinicz, L., and Kreppel, H. 1990. effect of glucose on survival of mice after
                poisoning with arsenic trioxide.   31st Spring Meeting of the Deutsche Gesellschaft Fuer
                Pharmakologie Und Toxikologie (German Society for Pharmacology and Toxicology)

No Oral        Reichl, F. X., Szinicz, L., Kreppel, H., Fichtl, B., and Forth, W. effect of glucose in  mice  after
Eco-SSLfor Arsenic
87
March 2005

-------
                acute experimental poisoning with arsenic trioxide (as2o3).  Arch. Toxicol. (1990)  64(4): 336-8

No Oral        Reichl, FX, Hunder, G, Liebl, B, Fichtl, B, and Forth, W.  1995. effect of dmps and various
                absorbents on the arsenic excretion in guinea-pigs after injection with as2o3.  Arch Toxicol.  69:
                712-717.

No Oral        Reichl, F. X., Kreppel, H., Szinicz, L., Fichtl, B., and Forth, W.  effect of glucose treatment on
                carbohydrate content in various organs in mice  after acute arsenic trioxide poisoning.  Vet. Hum.
                Toxicol. (1991)  33(3): 230-5.

n = l           Rhian, M and Moxon, AL.  1943. chronic selenium poisoning in dogs and its prevention by
                arsenic.   J. Pharmacol. Exp. Ther.  78:  249. RefID:  14494

Acu            Rhoads, K. and Sanders, C. L. 1985. lung clearance, translocation, and acute toxicity of arsenic,
                beryllium, cadmium, arsenic, lead, selenium, vanadium, and ytterbium oxides following deposition
                in rat lung.  Environmental Research  36(2): 359-378.

QAC           Ribeiro Sergio P, Villar Jesus, Downey Gregory P, Edelson Jeffrey D, and Slutsky Arthur S(A).
                1994. sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and
                protects rats  against sepsis.   Critical Care Medicine  22(6):  922-929.

Org met        Rice, D. A., Kennedy,  S., McMurray, C. H., and Blanchflower, W. J.  1985.  experimental 3-nitro-
                4-hydroxyphenylarsonic acid toxicosis in pigs.   Research in Veterinary Science 39(1): 47-51.

No Oral        Ridgway, L. P. and Karnofsky, D. A.  1952.  the effects of metals on the chick embryo:  toxicity
                and production of abnormalities in development.  Ann NYAcadSci.  55:  203-215.

CP             Riggs, B. S., Kulig, K., Knapp, G., and Rumack, B. H.  1988-1989. arsenic poisoning comparison
                of iv nac vs im bal vs po d Penicillamine.  Scientific Meeting of the American Association of
                Poison Control Centers

Rev            Riviere, J. E., Boosinger, T. R., and Everson, R.  J.  1981. inorganic arsenic toxicosis in cattle, a
                review of selected cases.  Modern Veterinary Practice 62(3):  209-211.

No Oral        Robertson, I. D., Harms, W. E., and Ketterer, P. J.  1984. accidental arsenical toxicity of cattle.
                Australian Veterinary Journal  61(11): 366-367.

Rev            Robinson, J. 1973.  industrial and agricultural pollution and the environment.  Roy. Soc.  Health
                J.93(2): 62-68,106

CP             Robinson, P. W., Boul, H. L., Joyce, N. I., and Reid, T. C.  1998.  residue monitoring in wool, and
                the environmental impacts of pesticideresidues.  ACIAR Proceedings Series (85):  100-114.

Abstract        Rodriguez, V. M(A), Diaz-Barriga, F., Jimenez-Capdeville, M. E., Carrizales, L., and Giordano
                M(A).  1999. the effects of arsenic (as) on neurobehavioral parameters.   Society for
                Neuroscience Abstracts.  25(1-2):  1830.

Org met        Rogers, E. H.,  Chernoff, N., and Kavlock, R. J.  1981.  the teratogenic potential of cacodylic acid
                in the rat and mouse.  Drug Chem Toxicol. 4(1):  49-61.

Aquatic        Roper, J. M., Cherry, D. S., Simmers, J. W., and Tatem, H. E. 1997.  bioaccumulation of toxicants
                in the zebra mussel, Dreissena polymorpha, at the times beach confined disposal facility, buffalo,
Eco-SSL for Arsenic                               88                                       March 2005

-------
                newyork.  Environ. Pollut.   94(2):  117-129.

Aquatic        Roper, J. M(A), Cherry, D. S., Simmers, J. W., and Tatem, H. E. 1996. bioaccumulation of
                toxicants in the zebra mussel, dreissena polymorpha, at the times beach confined disposal facility,
                buffalo, new york.  Environmental Pollution  94(2):  117-129.

Bio Ace        Roper, JM, Cherry, Ds, Simmer, JW, and Tatem, HE.  1996. bioaccumulation of toxicants in the
                zebra mussel, dreissena polymorpha, at the times beach confined disposal facility, buffalo, new
                york.  Environ. Pollution. 94(2): 117-129.

No Dose        Rosenberg, M. A., Wilcox, A. H., Chase, C. H. Ill, and Chase, C. H. Jr.  1976.  a mathematical
                formula as an aid in the treatment and prognosis ofcanine heartworm disease.   Veterinary
                Medicine and Small Animal Clinician 71(4): 496,498-503.

Unrel           Roux, D. J., Badenhorst, J. E., Du Preez, H. H., and Steyn, G. J.  1994. note on the occurrence of
                selected trace metals and organic compounds in water, sediment and biota of the crocodile river,
                eastern transvaal, south Africa.   Water S a.  20(4): 333-340.

Herp           Rowe, C. L. a, Kinney, O. M., Fiori, A. P., and Congdon, J. D. 1996. oral deformities in tadpoles
                (rana catesbeiana) associated with coal ash deposition: effects on grazing ability and growth.
                Freshwater Biology.  36(3):  723-730.

Orgmet        Roy, S., Ghosh, R. C., and Misra, S. K.  1991.  effect of sodium arsanilate on the growth rate of
                broilers.   Indian Veterinary Journal.  68(9): 855-857.

Drug           RoyChoudhury, Arati, Das, Tandra, Sharma, Archana, and Talukder, Geeta.  1996.  dietary  garlic
                extract in modifying clastogenic effects of inorganic arsenic in  mice : two-generation studies.
                Mutat. Res. (1996) 359(3): 165-70.

No Oral        Sabbioni, E., Marafante, E., Bertolero, F., andFoa, V.  1979.  inorganic arsenic: metabolic
                patterns and identification of arsenic binding components in the  rabbit.   Manage. Control Heavy
                Met. Environ. Int. Conf.  167-70 Publisher: CEP Consultants Ltd., Edinburgh, Scot.

FL             Sagner, G. 1973.  [the toxicology of arsenic in drinking water].  zur toxikologie des
                arsens im trinkwasser.  Schriftenreihe Des Vereins Fur Wasser-, Boden- Und Lufthygiene; 40

Surv           Sahli, BP.  1982.  arsenic concentrations in cattle liver, kidney and milk.    Vet Hum Toxicol.
                24(3): 173-174.

FL             Salahi, A. \9%2.Fast Transport Facility for Activation Analysis With High-Energy Neutrons.
                 Thesis (Dr. Techn.). INIS-MF-8945

Mix            Salbe, A. D., Morris, V. C., and Levander, O. A.  1993. selenium content of rat hair, nails  , and
                other tissues as affected by concurrent exposure to toxic Elements.  Nutr Res. 13(1): 31-36.

Surv           Salisbury, C. D. C., Chan, W., and Saschenbrecker, P.  W.  1991. multi-element concentrations in
                liver and kidney tissues from five species of Canadian slaughter Animals.   JAssoc off Anal Chem.
                74(4): 587-591.

Rev            Salmon, T. P. and Marsh, R. E. So- Vertebrate Pest Control and Managementsociety for Testing
                and Materials, 1979. PP. 84-98.  age as a factor in rodent susceptibility to rodenticides~a review.
Eco-SSLfor Arsenic
89
March 2005

-------
No Dose


Phys


Surv


No Dose


No Oral
Salplachta, J. and A. Vinkler. 2001. lactate dehyrogenase pattern in tissues of pigs exposed to
arsenic and cadmium - a pilot study.  Acta. Vet. BRNO. 70: 285-299.

Salt, A. N. and DeMott, J. 1994. time course of endolymph volume increase in experimental
hydrops measured in vivo with an ionic volume marker.   Hearing Research  74(1-2):  165-72.

Sample, B. E. and Suter, G. W. II.  1999. ecological risk assessment in a large river-reservoir : 4.
piscivorous wildlife.   Environmental Toxicology and Chemistry  18(4): 610-620.

Sample, Bradley E. and Suter, Glenn W. II.  ecological risk assessment in a large river-reservoir:
4. piscivorous wildlife.  Environ. Toxicol.  Chem. (1999)  18(4):  610-620.
Sarkar, M, Ghosh, D., Biswas, H., and Biswa, N. M. 1992. effect of sodium arsenite on
haematology in male albino rats.  Indian Journal of Physiology and Allied Sciences  46(3):
120.
                                                                                                   116-
No Dose        Satoh, H., Hashimoto, and Yamagiwa, J. 1971. pathological features of osmose poisoning in a
                cow: neurological observation.).   Jap. J. Vet. Sci.; 33: 89-105; 1971; (REF:49)

Chem Meth     Savage, I. and Haswell, S. J(A).  1998. the development of analytical methodology for
                simultaneous trace elemental analysis of blood plasma samples using total reflection x-ray
                fluorescence spectrometry.   Journal of'AnalyticalAtomic Spectrometry  13(10): 1119-1122.

Acu            Saxena, S. N., Sharma, K. M., and Singh, C. P.  1972. field trials on calcium arsenate as
                anthelmintic against commontapeworms of bikaneri, rampur bushair and cross-bred lambs under
                farmlevels of feeding.   Indian Veterinary Journal 49(4):  336-340.

Acute          Schafer, EW Jr and Bowles, WA Jr. 1985. acute oral toxicity and rpellency of 933 chemicals to
                house and deer mice.   Arch. Environ.  Contain. Toxicol.  14: 111-129.

No Oral        Schaumburg, H. H. 1980.Failure to Produce Arsenic Neurotoxicity in the Rat. An Experimental
                Study.   Final Rept. EPA-560/11-80-022

No Oral         Schaumburg, Herbert H. 1980.. failure to produce arsenic  neurotoxicity in the  rat.  an
                experimental study.    Report (1980) EPA-560/11-80-022; Order No. PB80-209505,  Avail.:
                NTISFrom: Gov. Rep. Announce. Ind U. S.) 1980, 80(24. 5061.   17 pp.

HHE           Schaupen, J. L., Fesmire, F. M., Roberge, R. J., Wears, R. L., and Sandroni, S.  massive arsenic
                ingestion in humans a characterization of 2 survivors.  1987 Meeting of the American Academy
                of Clinical Toxicology, American Association of Poison Control Centers, American Board of
                Medical Technology, Canadian Association of Poison Control Centers, Vancouver, British
                Columbia, Canada, September 27-october 2, 1987. Vet Hum Toxicol. 29 (6). 1987. 479-480.

Abstract        Schiller, C. M., Walden, R., Kee, T. E., Curley, W. H., Gafford, G. M., Shirkey, R. J., Lucier, G.
                W., and Fowler, B. A.  1978. development of a model to investigate interaction between alloxan-
                induced diabetes and exposure to arsenic - elevated levels of rat urinary enzymes.  Federation
                Proceedings  37:  505.

No COC        Schiller, CM, Fowler, B A, and Woods, JS. 1977. effects of arsenic on pyruvate dehydrogenase
                activation.   Environ Health Perspect.  19: 205-207.

Abstract        Schiller, CM, Walden, R, Kee, TE, Curley, WH, Gafford, GM, Shirkey, RJ, Lucier, GW, and
Eco-SSLfor Arsenic
                                   90
March 2005

-------
                Fowler, BA.  1978.  development of a model to investigate the interaction between alloxan-
                induced diabetes and exposure to arsenic: elevated levels of rat urinary enzymes.   Fed. Proc. 37:
                505.

FL             Schmid, A.  1983. pharmacological and lexicological evaluation of arsanilic acid andsodium
                arsanilate.   Deutsche  Tierarztliche Wochenschrift  90(1):  10-13.

Meth           Schmidt, P. F. and Barckhaus, R. H.  1991.  how can toxic elements be localized in histological
                sections by laser microprobe mass analysis (lamma)?   Progress in Histochemistry and
                Cytochemistry  23(1-4): 342-54.

In Vit          Schrader, T., Rienhofer, A., and Andreesen, J. R. 1999.  selenium-containing xanthine
                dehydrogenase from eubacterium barkeri.  European Journal of Biochemistry  264(3):  862-71.

HHE           Schrauzer, G. N., White, D. A., and Schneider, C. J.  1976.  inhibition of the genesis of
                spontaneous mammary tumors in c3h mice : effects of selenium and of selenium-antagonistic
                elements and their possible role in human breast cancer.  Bioinorg. Chem. (1976) 6(3):  265-70.

Dup            Schroeder, H. A. 1970. Metallic Micronutrients and Intermediary Metabolism: Progress Kept.
                No. 3 (Final).: 22 p.

Dup             Seidenberg, J. M. and Becker, R. A.  1987. a summary of the results of 55 chemicals screened for
                developmental toxicity in mice.   Teratog Carcinog Mutagen.  7(1):  17-28.

Rev            Selby, L. A., Case, A. A., Dorn, C. R., and Wagstaff, D. J.  1974.  public health hazards associated
                with arsenic poisoning in cattle.   Journal of the American Veterinary Medical Association
                165(No.ll): 1010-1014.

Surv           Selby, L. A., Case, A. A., Osweiler, G. D., and Hayes, H. M. Jr. CS Environmental Epidemiology
                Branch National Cancer Institute Bethesda.  epidemiology and toxicology of arsenic poisoning in
                domestic animals.

Rev            Selby, LA, case, AA, Osweiler, GD, and Hayes, HM Jr.  1977. epidemiology and toxicology of
                arsenic poisoning in domestic animals.  Environ Health Perspect.  19:  183-189.

Gene           Serbolisca, L., de Ferra, F., and Margarit, I.  1999.  manipulation of the dna coding for the
                desulphurizing activity in a new isolate of arthrobacter sp.  Applied Microbiology and
                Biotechnology  52(1):  122-6.

In Vit          Seymour, C. B. and Mothersill, C. 1987. the effect of glycolysis inhibitors on the recovery of
                cho-kl cells from split-dose irradiation.  Acta Oncologica  26(5): 367-71.

Surv           Shahin, Usama, Yi, Seung-Muk, Paode,  Rajendra D., and Holsen, Thomas M.  2000.  long-term
                elemental dry deposition fluxes measured around lake michigan with an automated dry deposition
                sampler. Environ. Sci. Technol. (2000)  34(10):  1887-1892 .

Rev            Shalat, Stuart L., Walker, Dana B., and Finnell, Richard H.  1996. role of arsenic as a
                reproductive  toxin with particular attention to neural tube defects.  J. Toxicol. Environ. Health
                48(3): 253-272.

Alt             Shaw, J. H.  1973. relation of arsenic supplements to dental caries and the periodontalsyndrome in
                experimental rodents.   Journal of Dental Research  52(3): 494-507.
Eco-SSL for Arsenic                               91                                       March 2005

-------
HHE           Sheabar, F. Z. and Yannai, S.  1989. invitro effects of cadmium and arsenite on glutathione-
                peroxidase, aspartate and alanine aminotransferases, cholinesterase and glucose-6-phosphate-
                dehydrogenase activities in blood.   Veterinary And Human Toxicology 31(6):  528-531.

No Oral        Shiomi, Kazuo, Chino, Makoto, and Kikuchi, Takeaki.  1990.  metabolism in mice  of arsenic
                compounds contained in the red alga porphyra yezoensis.   Appl. Organomet. Chem. (1990) 4(3):
                281-6.

Acute          Shum, Shu, Skarbovig, Jens, and Habersang, Rolf.  1981.  acute  lethal arsenite poisoning in
                mice  :  effect of treatment with n-acetylcysteine, d-penicillamine and dimercaprol on survival
                time.   Vet. Hum.  Toxicol.  (1981)  23(Suppl.  1): 39-42.

Drug           Siddiqui Rumana, Vohora Divya, and Vohora, S. B(A). 1999. proconvulsant effects of calcined
                arsenic preparations used in unani medicine.  Indian Journal of Pharmacology 31(2): 150-152.

Drug           Siebert, T.  1982.  selection of e. coli with plasmid-coded drug resistance by metal ionsin farm
                animals.   118pp.

Org met        Siewicki, T. C.  1981. tissue retention of arsenic in rats fed witch flounder (glyptocephalus
                cynoglossus) orcacodylic acid.  JNutr; 111  (4). 1981. 602-609.

Org met         Siewicki, T.  C. 1981. tissue retention of arsenic in rats fed witch flounder or cacodylicacid.
                Journal of Nutrition   111(4): 602-609.

Org met        Siewicki, T. C. and Leffel, E. C. 1980 .Effects of Dietary Cysteine on Arsenic Toxicity in the Rat:
                Up.

Org met        Siewicki, T. C. and Sydlowski, J. S.  excretion of arsenic by rats fed witch flounder
                (glyptocephalus cynoglossus) or cacodylic acid.  NutrRep Int; 24 (1). 1981. 121-128.

Orgmet        Siewicki, T. C. and Sydlowski, J. S.  1981.  excretion of arsenic by rats fed witch flounder or
                cacodylicacid.  Nutrition Reports International  24(1): 121-127.

Org met        Siewicki, Thomas C. and Leffel, Emory C.  effects of  dietary  cysteine on arsenic toxicity in the
                rat.  Nutr. Rep. Int. (1980) 22(1):  123-33.

Orgmet        Siewicki, Thomas C. and Sydlowski, Jane S.  1981.  excretion of arsenic by  rats fed witch
                flounder or cacodylic acid.  Nutr. Rep. Int. (1981)  24(1):   121-7.

FL             Silaev, A. A. and Lemeshevskaya, E. P.  1980. experimental data on the gonadotropic effect of
                cesium arsenate.  Gig. Tr. Prof. Zabol.  (1980) (9 ):  46-8.

HHE           Silbergeld, E. K.  1976.  neurochemical and pharmacological studies of central nervous system
                lead toxicology.   Health Effects of Occupational Lead and Arsenic Exposure: a Symposium;
                Carnow, B. W., Ed.

No Oral        Siller, F. R., Quintanilla-Vega,  B., Cebrian, M. E., and Albores, A. 1997. effects of arsenite
                pretreatment on the acute toxicity of parathion.   Toxicology  116(1-3): 59-65.

FL             Simek, M., Dvorak, R., Zendulka, I., Musil, V., and Krasa,  A. 1990.  effect of supplementary
                dolomite on rumen fermentation and metabolicindicators in cattle during fattening.   Sbornik
                Vedeckych Praci Vyzkumneho Ustavu Vyzivy Zvirat Pohorelice (23):  27-31.
Eco-SSLfor Arsenic
92
March 2005

-------
Mix            Simmons, Jane Ellen, Yang, Raymond S. H., Svendsgaard, David I, Thompson, Morrow B.,
                Seely, John C., and McDonald, Anthony.  1994. toxicology studies of a chemical mixture of 25
                groundwater contaminants: hepatic and renal assessment, response to carbon tetrachloride
                challenge, and influence of treatment-induced water restriction.  J. Toxicol. Environ. Health
                43(3): 305-25.

No Oral        Sinclair, A. N. 1976. fleece derangement of merino sheep infested by the itch mitepsorergates
                ovis.   New Zealand Veterinary Journal  24(7):  149-152.

FL             Sinkovics, G.  1974. therapeutic experiments and intestinal flora studies in swinedysentery.
                Zentralblatt Fur  Veterinarmedizin 21B(Heft9): 706-714.

FL              Skal'naia, M. G., Zhavoronkov, A. A., Skal'nyi, A. V., and Riabchikov, O. P.  1995.
                [morphologic characteristics of the thymus in pregnant and newborn mice exposed to sodium
                arsenite].  morfologicheskaia kharakteristika timusa beremennykh i novorozhdennykh
                myshei pri ekspozitsii arsenitom natriia.  Arkhiv Patologii  57(2): 52-8.

FL             Skal'naya, M. G., Zhavoronkov, A. A., Skal'nyi, A. V., and Ryabchikov, O. R.  1995.
                morphological characteristics of the thymus of pregnant and newborn mice exposed to sodium
                arsenite.  Arkhiv Patologii; 57 (2).  1995. 52-58.

FL             Skare, J. U.  1995.  environmental toxicology research at a veterinary college-veterinary institute.
                Norsk Veterinaertidsskrift. 107(4):  363-376.

Bio Ace        Slejkovec, Z, Byrne, AR, and Smodis, B.  1996. preliminary studies on arsenic species in some
                environmental samples.   Fresenius J. Anal. Chem. 354:  592-595.

Drug           Snider, T. H., Wientjes, M. G., Joiner, R. L., and Fisher, G. L.  1990. arsenic distribution in
                rabbits after lewisite administration and treatment with british anti-lewisite (bal).   Fundamental
                and Applied Toxicology   14(2): 262-72.

Sed             Snitz, F. L., Weber, W. J Jr., Barney, J. L., and Posner, J. C. 1977.  effects of calcium and
                sediment concentrations on the release of metals and nutrients from dredge spoil dispersions.
                ASTMSpec. Tech. Publ.  (1979) Volume Date 1977, STP 667, Aquat. Toxicol.,  322-41.

Acu            Sonali Biswas, Geeta Talukder, and Archana Sharma.  1999. prevention of cytotoxic effects of
                arsenic by short-term dietary supplementation with selenium in mice in vivo.   Mutation Research,
                Genetic Toxicology and Environmental Mutagenesis  441(1):  155-160.

Acu            Sonali Biswas, Geeta Talukder, and Archana Sharma.  1999. protection against cytotoxic effects
                of arsenic by dietarysupplementation with crude extract of emblica officinalis fruit.  Phytotherapy
                Research  13(6): 513-516.

Acu            Sporn, Alfred and Cirstea, Adriana.  1969. determination of the concomitant action of arsenic,
                copper, zinc, lead, and tin; acute toxicity.  Igiena (1969)  18(2):  81-90.

FL             Sporn, Alfred, Dinu, Ileana, and Stoenescu, Liana.  1968.  toxicity of zinc, copper, lead, and
                arsenic.  Igiena (1968)   17(12):  717-24.

Mix            Sporn DinnlStoenescuL, A.  1965-1973.  influence of concomitant administration of arsenic, lead,
                copper and zinc on the activity of some hepatic enzymes and on the ( sic ) oxidative
                phosphorylation.   Rev.  Roumaine Biochim.; 6(1)
Eco-SSL for Arsenic                               93                                        March 2005

-------
Abstract        Sram, R. J.  1975.  changes in the activity of chemical mutagens caused by various Compounds.
                MutatRes 29:195,1975

Carcin         Sram, R. J. 1976.  relation between acute and chronic exposures in mutagenicity studies in mice.
                Mutat. Res. (1976)  41(1): 25-42.

FL             Sram, R. J. 1977.  subacute and chronic effects of chemical mutagens on the frequency of
                dominant  lethals  in  mice.   Genet. Posledstviya Zagryaz. Okruzhayushchei Sredy (1977) :
                141-7. Editor(s): Dubinin, N. P. Publisher: "Nauka", Moscow, USSR. CODEN: 37BFAA.

In Vitro        Sram, R. J. 1976. relationship between acute and chronic exposures in mutagenicity studies in
                mice.  Mutation Research 41(1 spel. no): 25-42.

FL             Sram, R. J. and Bencko, V. 1974.  a contribution to the evaluation of the genetic risk of exposure
                to arsenic.   Cesk. Hyg. 19(6- 7): 3 08-315; 19 74. (14 References)

FL             Sram, R. J. and Bencko, V. 1974.  evaluation of the  genetic risk of exposure to arsenic.   Cesk.
                Hyg. (1974)   19(6-7):  308-15.

Bio Ace        Stadelman, W. J. 1973.  record of some chemical residues in poultry products.
                BioScience23(7): 424-428; 1973(REF:38)

Unrel           Stainki, D. R., Raiser, A. G., Graca, D. L., and Becker, C.  1995. the effect of galium arsenate
                laser radiation on peripheral nerveregeneration in dogs after surgery.  Arquivo Brasileiro De
                Medicina Veterinaria e Zootecnia  47(6):  763-771.

Acu            Steinrauf, L.  1976. the effect  of thiocholesterol on the acute lethality of selected heavy metals in
                the mouse.  Society of Toxicology: Fifteenth Annual Meeting:Abstracts. London: Academic
                Press, 1976. Pp. 129, 131

Mix            Stendell, R. C., Beyer, W. N., and Stehn, R. A.  1989. accumulation of lead and organochlorine
                residues in captive american kestrels fed pine voles from apple orchards.  J Wildl Dis.  25(3):
                o oo o c\ i
                388-391.
Surv
 Rev
CP
Acu
Abstract
Stevens, J. B.  1991.  disposition of toxic metals in the agricultural food chain: 1. steady-state
bovine milk biotransfer Factors.   Environ Sci Technol.  25(7):  1289-1294.

Stump, D. G., Clevidence, K. J., Knapp, J. F., Holson, J. F., and Farr, C. H. an oral developmental
toxicity study of arsenic trioxide in rats.  Teratology 1998Apr/May;57(4/5):216-7

Stump, D. G., Fleeman, T. L., Nemec, M. D., Holson, J. F., and Farr, C. H. 1998 . evaluation of
the teratogenicity of sodium arsenate and arsenic trioxide following single oral intraperitoneal
administration in rats.  Thirty-eighth Annual Meeting of the Teratology Society and the 22nd
Annual Meeting of the Neurobehavioral Teratology Society and llth International Conference of
the Organization of Teratology Information

Stump, D. G., Holson, J. F., Fleeman, T. L., Nemec, M. D., and Farr, C. H. comparative effects of
single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero
Development.   Teratology; 60 (5). 1999. 283-291.

 Stump, DG, Clevidence, KJ, Knapp, JF, Holson, JF, and Farr, CH.  1998. an oral developmental
study of arsenic trioxide in rats.   Terratology.  57(4/5): 216-217.
Eco-SSLfor Arsenic
                                   94
March 2005

-------
Abstract        Stump, DG, Fleeman, TL, Nemec, MD, Holson, JF, and Farr, CH.  1998.  evaluation of the
                teratogenaity of sodium arsenate and arsenic trioxide following single oral or intraperitoneal
                administration in rats.  Teratology.  57(4/5):  217.

Abstract        Stump, DG, Urlich, CE, Holson, JF, and Farr, CH.  1998.  an inhalation developmental toxicity
                study of arsenic trioxide in rats.   Teratology. 57(4/5): 216.

Abstract        Su, L and Csallany, AS.  unknown,  relationships of age, vitamin e, dppd and selenium to
                glutathione peroxidase activity and lipofuscin pigment concentration in mice.  Fed. Proc.
                unknown:  1094.

Org met        Sullivan, T. W. and Al-Timimi, A. A. 1972.  safety and toxicity of dietary organic arsenicals
                relative toperformance of young turkeys. 2. carbarsone. 3. nitarsone. 4.roxarsone.  Poultry
                Science  51(No.5):  1498-1501; 1582-1586; 1641-1644.

Org met        Sullivan, T. W. and Al-Timimi, A. A. 1972.  safety and toxicity of dietary organic arsenicals
                relative toperformance of young turkeys, 4. roxarsone.  Poultry Science  51(5):  1641-1644.

Org met        Sullivan, T. W. and Al-Timimi, A. A. 1972.  safety and toxicity of dietary organic arsenicals
                relative toperformance of young turkeys. 3. nitarsone.  Poultry Science   51(5):  1582-1586.

FL             Surcel, Didi, Gabor, Silvia, Anca, Zoe, and Ciugudeanu, Maria. 1981. interactions between lead,
                arsenic and selenium on some immunological parameters.  Rev. Ig. Bacterial., Virusol.,
                Parazitol., Epidemiol., Pneumoftiziol, Ig.   30(2): 123-30.

FL             Suren, K. and Kreuzer, W. CS Inst. Hygiene Univ. Veterinarstrasse  13 Federal Republic.  1979.
                arsenic residues in slaughter pigs after consumption of feed withvarious contents of arsanilic acid.
                 Schlachten Und Vermarkten  49(7): 203-209.

Unrel           Sutton, A. L., Brumm, M. C., Kelly, D. T., Henderson, C. A., and Mayrose, V. B.  1980.  effect of
                dietary salt, arsenic and copper additions and wastemanagement systems on selected microbial
                organisms in swine wastes.   Journal of Animal Science  51(4): 791-797.

InVit           Suzuki, Keiji, Kawaharada, Umeko, Tamura, Yuji, and Nakajima, Katsuyuki.  1991.  effects of
                metals on  rat glioma cells (c6).  Biomed. Res. Trace Elem  2(2): 111-12.

Unrel            Swanson, S. M. and Roest, N. 1997. biophysical effects of uranium mining in Canada and some
                suggestions for biomarkers of effects.  Canadian Technical Report of Fisheries and Aquatic
                Sciences 0(2144): 33.

Surv           Swiggart, RC, Whitehead, CJ Jr., Curley, A, and Kellogg, FE.  1972. wildlife kill resulting from
                the misuse  of arsenic acid herbicide.   Bull. Environ. Contain.  Toxicol.  8(2):  122-128.

In Vit           Szczepanska-Konkel, M., Yusufi, A. N., VanScoy, M., Webster, S. K., and Dousa, T. P.  1986.
                phosphonocarboxylic acids as specific inhibitors of na+-dependent transport of phosphate across
                renal brush border membrane.  Journal of Biological Chemistry 261(14):  6375-83.

No Oral        Tadlock, C. H. and Aposhian, H. V.  1980.  protection of mice against the lethal effects of sodium
                arsenite by 2,3 dimercapto-1-propane-sulfonic acid and dimercaptosuccinic acid.   Biochemical
                and Biophysical Research Communications  94(2): 501-7.

Abstract        Tadlock, C. H., Rovner, B. A., and Aposhian, H. V.  1980. water soluble  analogs of british
Eco-SSLfor Arsenic
95
March 2005

-------
No Oral
antilewisite are more potent than penicillamine analogs in preventing arsenic lethality.   64th
Annual Meeting of the Fed. Am. Soc. Exp. Biol.

Takahashi, K., Yamauchi, H., Mashiko, M., and Yamamura, Y. 1990.  [effect of s-
adenosylmethionine on methylation of inorganic arsenic].  Nippon Eiseigaku Zasshi  45(2):  613-
No Oral        Takeuchi, I. K.  embryo toxicity of arsenic-acid light microscopy and electron microscopy of its
                effect on neurulation stage rat embryo. Journal of Toxicological Sciences.  4(4). 1979 (Reed.
                1980). 405-416.

Meth           Tamborini, P., Sigg, H., and Zbinden, G.  1990. acute toxicity testing in the nonlethal dose range:
                a new approach.  Regulatory Toxicology and Pharmacology  12(1): 69-87.

FL             Tamura, S. 1978. metabolism of arsenic: 20. effect of arsenic on the developing brain of rat.
                FoliaPharmacolJpn; 74 (1). 1978 1-14

FL             Tamura, S.  1978. metabolism of arsenic part 22 effect of arsenic on the spontaneous motor
                activity avoidance conditioning extinction and swimming record in rats.   Folia Pharmacologica
                Japonica. 74 (7). 1978 (Reed. 1979).  783-796.

FL             Tamura, S. 1974. [studies on the arsenic metabolism (report 11). acute toxicity of arsenic trioxide
                (author's transl)].  ShikaGakuho  74(10):  1478-81.

FL             Tamura, S., Kobayashi, K., and Kojima, H. 1974. studies on arsenic metabolism part 10 effect of
                arsenite upon the spontaneous activity in rats.  Folia Pharmacologica Japonica.  70 (2). 1974
                193-197

FL             Tamura, S. andNozaki, S. 1972.  [arsenic metabolism. 5. blood brain barrier and arsenite, with
                special reference to the effect of the feed].  Nippon Yakurigaku Zasshi  68(6): 800-8.

Abstract        Tamura, S. and Tanaka, I.  placenta! transfer of arsenic tri oxide.  Jpn JPharmacol; 25 (SUPPL).
                1975 (RECD 1976) 133P-134P

FL             Tamura, Shikichi, Nozaki, Shigeru, and Tsuzuki,  Shitaro.  1972. arsenic metabolism, iv. effect
                of food on arsenic tolerance in the digestive tract.   Nippon Yakurigaku Zasshi (1972)  68(5):
                586-601
FL
FL
FL
FL
 Tamura, Shunkichi.  1978.  metabolism of arsenic,  effect of arsenic on the spontaneous motor
activity, avoidance condition, extinction and swimming record in rats.  Nippon Yakurigaku Zasshi
(1978)  74(7): 783-95.

Tamura, Shunkichi.  1978.  metabolism of arsenic,  part 20.  effect of arsenic on the developing
brain of  rat.  Nippon Yakurigaku Zasshi (1978)  74(1):  1-14..

Tamura, Shunkichi, Maehashi, Hiroshi, Nozaki, Shigeru, and Mizukami, Reiko.  1974. arsenic
metabolism, xii. effects of polypeptone and polyamine on arsenic accumulation in certain organs
and on the excretion.  Nippon Yakurigaku Zasshi (1974)  70(6):  831-6..

Tamura, Shunkichi, Maehashi, Hiroshi, Ozawa, Reiko, and Goto, Kazuyoshi.  1977.  studies on
arsenic metabolism, xx. arsenic accumulation in the organs and excretion into the feces and urine
of  rats  chronically poisoned with arsenic.   Nippon Yakurigaku Zasshi (1977)  73(8): 877-85.
Eco-SSLfor Arsenic
                                   96
March 2005

-------
FL             Tamura, Shunkichi, Mizukami, Reiko, and Tanaka, Izumi.  1974.  arsenic metabolism,  xiv.
                effects of lactalbumin, egg albumin on arsenic excretion and storage.  Nippon Yakurigaku Zasshi
                (1974)  70(6):  843-7.

FL             Tamura, Shunkichi, Nozaki, Shigeru, Maehashi, Hiroshi, and Tanaka, Izumi.  1974. arsenic
                metabolism, xiii. effects of methionine, taurine, and cysteine on arsenic accumulation in certain
                organs and on the excretion rates.   Nippon Yakurigaku Zasshi (1974)  70(6): 837-41.

Dup            Tanaka, I.  studies on arsenic metabolism. 17. studies of placenta! transfer andantidotes and diets
                on placental transfer.

FL             Tanaka, I.  1976.  [arsenic metabolism. (17) studies of placental transfer of arsenic and the effects
                of antidotes and diet].   Nippon Yakurigaku Zasshi  72(6): 673-87.

FL             Tanaka, Izumi.  studies on arsenic metabolism, (xvii).  studies on placental transfer and the effects
                of antidotes and diets on placental transfer.   Nippon Yakurigaku Zasshi (1976)  72(6): 673-87

No Oral        TandraDas, Choudhury, A. R., Archana Sharma, and Geeta Talukder.  1993.  modification of
                cytotoxic effects of inorganic arsenic by a crudeextract of allium sativum 1. in mice.
                InternationalJournalofPharmacognosy 31(4): 316-320.

FL             Taranov, G. S.  1994.  feed yeasts (for feeding mink).  Krolikovodstvo i Zverovodstvo (3): 8.

Alt             Tariq, M. A. and Preiss, I. L. 1994. fluctuations in fe, cu, zn, br, as, se, and rb concentrations in
                c571/j mice bearing bw7756 murine hepatoma using radioisotope-induced x-ray fluorescence.
                Biol Trace Elem Res.  42(2):  97-114.

No Oral        Tariq, Muhammad Ashraf and Preiss,  Ivor L.  fluctuations in fe, cu, zn, br, as, se, and rb
                concentrations in c571/j mice bearing bw7756 murine hepatoma using radioisotope-induced x-ray
                fluorescence.  Biol. Trace Elem. Res. (1994)  42(2): 97-114.

Rev             Task Group Metal Interact, Int.  1978. factors influencing metabolism and toxicity of metals a
                consensus Report.   Environ Health Perspect. 25:  3-41.

Abstract        Taubeneck, M. W., Daston, G. P., Rogers, J. M., and Keen, C. L.  evidence for a common pathway
                of developmental toxicity of urethane, melphalan and arsenic: impact on maternal and embryonic
                zinc status.  Teratology 1991 May;43(5):469

Acu             Taubeneck, Marie Weldon, Daston, George P., Rogers, John M., and Keen, Carl L. altered
                maternal zinc metabolism following exposure to diverse developmental  toxicants.  Reprod.
                Toxicol. (1994)  8(1): 25-40.

Abstract        Taubeneck, MW, Daston, GP, Rogers, JM, and Keen, CL.  1991.  evidence for a common pathway
                of developmental toxicity of urethane, melphalan and arsenic: impact on  maternal and emryonic
                zinc status.  Teratology. 43(5): 371-542.

Unrel           Taylor, J. D., Gibson,  J. A., and Yeates, C. E. F.  1991.  furazolidone toxicity in dairy calves.
                Australian  Veterinary Journal  68(5):  182-183.

FL             Teuscher, E., Sauvageau, R., and Tellier, P.  1985.  case of accidental arsenic poisoning in cattle,
                with reference todevelopment of histopathological lesions.   Schweizer Archiv Fur Tierheilkunde
                127(4): 257-266.
Eco-SSLfor Arsenic
97
March 2005

-------
Abstract        Thacker, G. T., Patterson, B. L., and Hood, R. D.   1977.  effects of administration route on
                arsenate teratogenesis in mice.  Teratology;  15 (2). 1977 30A-31A

Mix            Thapar, N. T., Guenthner, E., Carlson, C. W., and Olson,  O. E. 1969. dietary selenium and
                arsenic additions to diets for chickens over a life cycle.   Poult Sci.  48(6): 1987-93.

                Thapar, NT, Guenther, E, Carlson, CW, and Olson, OE.  1969. dietary selenium and arsenic
                additions to diets for chickens over a half cycle.   Poult. Sci. 48:  1988.

Bio Ace         Theis, M and Gregory, D.  1994. residues of lead, cadmium, and arsenic in livers of mexican free-
                tailed bats.  Bull. Environ. Contam. Toxicol. 52(5):  641-648.

Rev            Thompson, L. I, Hall, J. O., and Meerdink, G. L.   1991. toxic effects of trace element excess.
                Veterinary Clinics of North America, Food Animal Practice. 7( 1): 277-306.

FL             Tishchenko, L. G.  1983.  histological studies of anoplocephalids after the action ofanthelmintics
                and experimental bio-control.  Byulleten' Vsesoyuznogo Instituta  Gel'Mintologii Im. K.I.
                Skryabina(No.35): 72-73.

Drug           Tobey, R. A., Enger, M. D., Griffith, J. K., and Hildebrand, C. E.  1982.  inducible protective
                proteins: a potentially novel approach to chemotherapy.   Govt Reports Announcements & Index
                (GRA&I)

No Oral        Tripathi, Neelima, Kannan, G. M., Pant, B. P., Jaiswal, D. K., Malhotra, P. R., and Flora,  S. J. S.
                1977.  arsenic-induced changes in certain neurotransmitter levels and their recoveries following
                chelationin  rat  whole brain.  Toxicol. Lett. (1997)  92(3): 201-208 .

An Prod        Troeger, K., Reuter, G., and Schneider, D.  1983.  use  of dried chicken manure in cattle feeding,
                from the aspects of meathygiene and feed technology,  i. microorganisms, nutrients and residuesin
                battery-hen manure and maize silage used as basal feed.   Berliner UndMunchener Tierarztliche
                Wochenschrift  96(11): 388-397.

FL             Trojan, S.  1980.  [adaptation of newborn rats to repeated exposure to histotoxic hypoxia (author's
                transl)].  adaptace novorozenych krys na opakovane vystaveni histotoxicke hypoxii.
                Bratislavske Lekarske Listy  73(6):  662-70.

FL             Trojan, S., Jilek, L., and Mourek, J.  1967.  [effect of repeated sodium arsenite administration on
                oxygen consumption in the rat brain and liver during development].   vliv opakovaneho
                podavani arzenitanu sodneho na spotrebu kysliku v mozku a v jatrech krys behem ontogeneze.
                SbornikLekarsky  69(12):  361-5.

FL             Trojan, S., Jilek, L., and Travnickova, E. 1968.  effect of repeated administration of sodium
                arsenate on the developing organism abstract rat ischemia development retardation.  CESK
                FYSIOL.  Ceskoslovenska Fysiologie.  17 (1). 1968 32

FL             Trojan, Stanislav and Jilek, L.  1967.  influence of repeated administration of sodium arsenite on
                the reflex activity of  rats.  Sb. Lek. (1967)  69(6): 175-80.

Unrel           True Anne E, Scarrow Robert C, Randall Clayton R, Holz Richard C, and Que Lawrence  Jr(A).
                1993.  exafs studies of uteroferrin and its anion complexes.   Journal of the American Chemical
                Society  115(10):  4246-4255.
Eco-SSL for Arsenic                                98                                       March 2005

-------
Surv           Trust, K. A., Rummel, K. T., Scheuhammer, A. M., Brisbin, I. L. Jr., and Hooper, M. J. 2000.
                contaminant exposure and biomarker responses in spectacled eiders (somateria fischeri) from st.
                lawrence island, alaska.  Arch. Environ. Contam. Toxicol.  (2000)  38(1):  107-113.

No Oral        Tsukamoto, H, Parker, HR, Gribble, DH, Mariassy, A, and Peoples, SA.  1983.  nephrotoxicity of
                sodium arsenate in dogs.  Am. J. Vet. Res.  44(12): 2324-2330.

No Oral        Tsukamoto, H, Parker, HR, and Peoples SA. 1983.  metabolism and renal handling of sodium
                arsenate in dogs.  Am. J. Vet. Res. 44(12): 2331-2335.

FL             Tsuneishi, E., Takeshita, K., Yoshida, S., and Nishimura, K. Tohoku National Agricultural
                Experiment Station Morioka Japan. 1981.  accumulation and excretion of dietary arsenic (as) in
                cattle, and survey of as content in organs of cattle produced in tohoku district [japan].   Bulletin of
                the Tohoku National Agricultural Experiment Station. (No. 65) P. 167-174

FL             Tsutsumi, S., Usui, Y., and Matsumoto, Y.  1974. [arsenic metabolism, (report no. 8) inhibition of
                succinic acid dehydrogenase activity of arsenic trichloride in rats; influence of different types of
                diet].  Nippon Yakurigaku Zasshi 70(4):  515-22.

FL             Tsutsumi, Shoji.  1972.  fundamental studies on arsenic metabolism, fate of radioisotope arsenic-
                74 administered to experimental animals and the pharmacodynamic action of the antidotes on the
                arsenic poisoning.  Shika Gakuho (1972)  72(5): 1-25

InVit          Tuena De Gomez-Puyou M(A), Sandoval Francisca, and Gomez-Puyou, A.  1995. synthesis of
                medium pyrophosphate by soluble mitochondrial f-1 through dimethyl sulfoxide-water transitions.
                Journal of Biological Chemistry 270(28): 16820-16825.

FL             Tulakina, N. V., Novikov, Yu. V., Plitman, S. L, Kochetkova, T. A., Lastochkina, K. O., and
                Khvastunov, R. M. 1987. standards for arsenic in drinking water of different hardness.  Gigiena
                i Sanitariya (1):  21-24.

Surv           Turner, J. C., Solly, S. R. B., Mol-Krijnen, J. C. M., and Shanks, V.  1978. organochlorine,
                fluorine, and heavy-metal levels in some birds from newzealand estuaries.  New Zealand Journal
                ofScience  21(1): 99-102.

Phys           Ullrich, K. J. and Murer, H. 1982. sulphate and phosphate transport in the renal proximal tubule.
                Philosophical Transactions of the Royal Society of London. Series B:

Phys           Ullrich, K. J., Papavassiliou, F., Rumrich,  G., andFritzsch, G. 1985.  contraluminal phosphate
                transport in the proximal tubule of the rat kidney.  Pflugers Archiv  405 Suppl 1: S106-9.

Phys           Ullrich, K. J., Rumrich,  G., and Kloss, S.  1984.  contraluminal sulfate transport in the proximal
                tubule of the rat kidney, i. kinetics, effects of k+, na+, ca2+, h+, and anions.  Pflugers Archiv
                402(3): 264-71.

Abstract        Umpierre, C. C.  1981. embryo lethal and teratogenic effects of sodium arsenite in Rats.  21st
                Annual Meeting of the Teratology Society

Unrel          Underwood, E. J. 1976.  mineral imbalances in farm animals and their study and diagnosis with
                isotopic tracers.  Atomic Energy Review   14(4): 591-619.

Rev            Underwood, E. J. 1981.: ix+180pp.
Eco-SSLfor Arsenic
99
March 2005

-------
BioAcc         US Army.  1976.: 9.

Rev            USDOI.  1988.

                USEPA.  1998.
Rev
Uthus, E. O. evidence for arsenic essentiality.   ENVIRON GEOCHEMHEALTH; 14 (2). 1992.
55-58.
Abstract        Uthus, E. O.  1997.  arsenic deprivation decreases the specific activity of betaine homocysteine
                methyltransferase (bhmt) in rats fed diets low in folic acid but supplemented with choline.
                FASEB Journal  11(3):  A148.

Mix            Uthus, E. O. and Kang, Y. J. effect of buthionine sulfoximine on the response to arsenic
                deprivation in female  rats.  J. Trace Elem. Exp. Med (1998)  11(1):  29-36.

CP             Uthus, E. O. and Neilsen, F. H. 1983.  zinc status affects the induction of arsenic deficiency in
                chicks.   67th Annual Meeting of the Federation of American Societies for Experimental Biology,
                Chicago, III, Usa, April 10-15, 1983. Fed Proc.  42  (4). 1983. Abstract 3108.

CP             Uthus, E. O. and Nielsen, F. H. arsenic-zinc interactions in chicks.   Proc. N. D. Acad. Sci. (1980)
                :  34,54.
CP
CP
Abstract
NoCOC
CP
CP
Abstract
Nut def
Nut def
Uthus, E. O. and Nielsen, F. H.  1980.  arsenic deprivation and arsenic-zinc interactions in the
chick.  Spurenelem.-Symp.: Arsen 3rd  :  33-9.  Editor(s): Anke, Manfred; Schneider, Hans-
Joachim; Brueckner, Chr. Publisher: Friedrich-Schiller- Univ. Jena Abt. Wiss. Publ., Jena, Ger.
Dem. Rep.

Uthus, E. O. and Nielsen, F. H.  1983.  influence of arsenic on arginine metabolism in chicks .
Spurenelem.-Symp. 4th :  105-10.  Editor(s): Anke, Manfred. Publisher: Friedrich-Schiller-Univ.,
Jena, Ger. Dem. Rep..

Uthus, E. O. and Nielsen, F. H.  1987.  effects of dietary taurine on arsenic deprivation in the
spontaneously hypertensive rat.  Federation Proceedings 46:  1007.

Uthus, E. O. and Nielsen, F. H.  1987.  methyl depletion affects the response of rats to arsenic
deprivation.  Nutrition Research  7(10):  1061-1072.

 Uthus, E. O. and Poellot, R.  effects of dietary methionine on signs of arsenic deprivation in rats.
Proceedings Of The North Dakota Academy Of Science.   Apr 1990. v. 44 p. 90.

Uthus, E. O. and Poellot, R. A.  1998.  high dietary sodium arsenite affects kidney trace element
concentrations.  FASEB Journal  12(4):  A221.

Uthus, EO and Nielson, FH.  1987.  effects of dietary taurine on arsenic deprivation in the
spontaneously hypertensive rat.  Fed Proc.  46(3):  1007.

Uthus, Eric and Poellot, Rhonda, effect of dietary  pyridoxine on arsenic deprivation in rats.
Magnesium Trace Elem. (1993)  Volume Date 1992, 10(5-6):  339-47.

Uthus, Eric and Poellot, Rhonda, effect of methionine deficiency on arsenic deprivation in rats  :
growth , blood parameters, organ weight/body weight ratios, and tissue trace element
Eco-SSLfor Arsenic
                                   100
March 2005

-------
                concentration.  J. Trace Elem. Exp. Med. (1992)  5(3):  153-64.

Nut def         Uthus, Eric O. diethyl maleate, an in vivo chemical depletor of glutathione, affects the response of
                male and female rats  to arsenic deprivation.   Biol. Trace Elem. Res. (1994)  46(3):  247-59

Nut def         Uthus, Eric O. effects of arsenic deprivation in hamsters.  Magnesium Trace Elem. (1991)
                Volume Date 1990, 9(4):  227-32.

Rev            Uthus, Eric O. evidence for arsenic essentiality.   Environ.  Geochem. Health (1992)  14(2):  55-8


Nut def         Uthus, Eric O. and Nielsen, Forrest H.  methyl depletion affects the response of rats  to arsenic
                deprivation.  Nutr. Res. (N. Y.) (1987)  7(10):  1061-72.

Bio Ace         Vadhanavikit, S., Ip,  C., and Ganther, H. E. metabolites of sodium selenite and methylated
                selenium compounds administered at cancer chemoprevention levels in the  rat.  Xenobiotica
                (1993)  23(7): 731-45.

Prim           Vahter, M, Couch, R, Nermell, B, and Nilsson, R. 1995.  lack of methylation of inorganic arsenic
                in the chimpanzee.   Toxicol. Appl. Pharmacol. 133(2): 262-268.

No Oral        Vahter, M and Marafante, E.  1987. effects of low dietary intake of methionine, chlorine or
                proteins on the biotransformation of asenite in the rabbit.   Toxicol. Letters.  37:  41-46.

CP             Vahter, M. and Marafante, E.  1988. intracellular distribution and chemical forms of arsenic in
                rabbits exposed to Arsenate.   First International Meeting on Molecular Mechanisms of Metal
                Toxicity and Carcinogenicity

Rev            Vahter, Marie.  1999. methylation of inorganic arsenic in different mammalian species and
                population groups.   Sci. Prog. (Northwood U. K.)  82(1):  69-88

Acu            Van den Heuvel, M. J., Clark, D. G., Fielder, R. J., Koundakjian, P. P., Oliver, G. J. A., Felling,
                D., Tomlinson, N. J., and Walker, A. P. 1990. the international validation of a fixed-dose
                procedure as an alternative to the classical Id50 test.   Food Chem. Toxicol. (1990) 28( 7): 469-
                82.

Surv           Van Der Veen, N. G. and Vreman, K.  1986. transfer of cadmium lead mercury and arsenic from
                feed into various organs and tissues of fattening lambs.  NETH JAGRIC SCI.  34(2):  145-154.

Abstract        Van Gelder, G. A., Buck, W. B., Osweiler, G. D.,  and Stahr, H. M. 1972.  research activities of a
                veterinary toxicology laboratory.   Clinical Toxicology 5(2): 271-81.

Drug           van Praag, M. C., Tseng, L. N., Mommaas, A. M., Boom, B. W., and Vermeer, B. J.  1993.
                minimising the risks of puva treatment.   Drug Safety  8(5): 340-9.

Mix            Van Vleet, J. F.  1982.  amounts of twelve elements required to induce selenium vitamin e
                deficiency in ducklings. Am. J. Vet. Res. 43(5):  851-857.

Dead           VanUlsen, F. W. one hundred poisoned dogs.   Tijdschr.  Diergeneesk. 99(18): 947-948; 1974.(2
                References)

Abstract        Vedel, G. C., Harrison, W. P., Baxley, M. N., and Hood, R.  D.  influence of an arsenic chelating
Eco-SSLfor Arsenic
101
March 2005

-------
                agent (bal) on the outcome of prenatal arsenite exposure in mice.
                73A.1980
                         Teratology.   27:724-
Mix            Veen, N. G. van der and Vreman, K.  1986.  transfer of cadmium, lead, mercury and arsenic from
                feed into variousorgans and tissues of fattening lambs.  Netherlands Journal of Agricultural
                Science  34(2): 145-153.

Mix            Veeramachaneni, D. N. R. and Amann, J. S. Palmer And R P. 1995. sexual dysfunction and
                abnormal acrosomes in rabbits following infantile exposure to a mixture of chemical contaminants
                in drinking water.  Biology of Reproduction  52(SUPPL. 1): 171.

Rev            Venugopal, B. andLuckey, T. D. 1978Metal Toxicity in Mammals  1

Surv           Vermeer, K and Thompson, JAJ. 1992.  arsenic and copper residues in waterbirds and their food
                down inlet from the island copper mill.  Bull Environ Contam Toxicol.  48(5):  733-738.

FL             Vibe, P. P. 1976. parasitic coenoses in sheep.   Veterinariya, Moscow (6): 58-60.

Mix            Vijchulata, Pravee, Henry, P.  R., Ammerman, C. B., Becker, H. N.,  and Palmer, A. Z.
                performance and tissue mineral composition of ruminants fed cage layer manure in combination
                with monensin.  J.Anim. Sci. (1980). 50(1): 48-56.

No COC        Vincent, J. B., Crowder, M. W., and Averill,  B. A.  1991. spectroscopic and kinetics studies of a
                high-salt-stabilized form of the purple acid phosphatase from bovine spleen.  Biochemistry. 30
                (12). 1991. 3025-3034.

FL             Viuf, B. T. 1992. report, 4: department of chemical analyses (additives and undesirable
                substances).  4: meddelelser fra kemisk afdeling.  Plantedirektoratets Beretning.
                Foder, Goedning, Voksemedier, EF-Stoetteordninger.  (No.l) P. 59-79

Mix            Vodela, J. K., Lenz, S. D., Renden, J. A., and Kemppainen, B. W.  1996.  reproductive
                performance altered by chemical mixture.  Toxicologist 1996Mar;30(l Pt 2): 192

Mix            Vodela, J. K., Lenz, S. D., Renden, J. A., Mcelhenney, W. H., and Kemppainen, B. W.  1997.
                drinking water contaminants (arsenic, cadmium, lead, benzene, and trichloroethylene): 2. effects
                on reproductive performance, egg quality, and embryo toxicity in broiler breeders.  Poultry
                Science.  76(11):  1493-1500.

Mix            Vodela, J. K., Renden, J. A., Lenz, S. D., Mcelhenney, W. H., and Kemppainen, B. W.  1997.
                drinking water contaminants (arsenic, cadmium, lead, benzene, and trichloroethylene): 1.
                interaction of contaminants with nutritional status on general performance and immune function in
                broiler chickens.  Poultry Science.  76(11):  1474-1492.

FL             Vogler, G. 1967.  [intoxication of man and animals with phytoplankton toxins from surface
                waters].   intoxikationen von mensch und tier durch phytoplanktontoxine aus
                oberflachengewassern.  Archiv Fur Hygiene UndBakteriologie  151(1):  1-22.

Abstract        Vreman, K. and De Ruig W G. 1980. supplementation of diet with arsenic lead cadmium and
                mercury in lactating dairy cows and young fattening bulls appearance of various heavy metals in
                various edible tissues.   34th  Convention of the Society for the Nutritional Physiology of Domestic
                Animals, Goettingen, West Germany, March  12-14,  1980. Z Tierphysiol Tierernaehr Futtermittelk.
                44 (1). 1980. 10-11.
Eco-SSLfor Arsenic
102
March 2005

-------
FL
Mix
Diss
Unrel
Abstract
Mix
Unrel
Bio Ace
FL
CP
InVit
Unrel
InVit
InVit
Unrel
Vreman, K. and Ruig, W. G. de.  1980.  supplements of arsenic, lead, cadmium and mercury for
lactating dairy cows and young fattening bulls, the transfer (of the heavy metals) todifferent edible
tissues.  ZeitschriftFur Tierphysiologie, Tierernahrung UndFuttermittelkunde  44(1):  10-11.

Vreman, K., Van Der Veen, N. G., Van Der Molen, E. I, and De Ruig, W. G. 1986. transfer of
cadmium lead mercury and arsenic from feed into milk and various tissues of dairy cows chemical
and pathological Data.   Neth JAgric Sci. 34(2):  129-144.

Vreman, K. and Veen, N. G. van der.  1981. carry-over of lead, cadmium, mercury and arsenic
from animal feed toedible products of fattening lambs. rapport, instituut voor
veevoedingsonderzoek "hoorn".  (136):  17 pp.

 Vyaizenen,  G. N., Tokar', A. I., Gulyaev, V. A, Marinets, R. M, and Struchkov, A. A. 1998.
conifer extract for obtaining ecologically clean product.  Kormoproizvodstvo (1):  28-29.

Wagstaff, D. J.  1972. arsenic trioxide: stimulation of liver enzyme detoxication activity.
Toxicol. Appl. Pharmacol; 22(2): 310; 1972

Wagstaff, D. J.  alteration of hepatic de toxication enzyme activity by dietary arsenic tri oxide.
Food and Cosmetics Toxicology.  16 (5).  1978. 423-426. RefID:  15190

Waheed, A.  and Van Etten R L. 1980 the structural basis of the anomalous kinetics of rabbit liver
aryl  sulfatase aec-3.1.6.1.   Archives of Biochemistry and Biophysics. 203(1). 1980. 11-24.

Waheed, S., Fatima, L, Mannan, A., Chaudhary, M. S., and Qureshi, I. H.  1985.  trace element
concentration in egg- yolk and egg-white of farm and domestic  chicken  eggs.  Int. J. Environ.
Anal. Chem. (1985)  21(4):  333-44.
Wan, B., Wang, C.:
chicken Embryos.
Dis) 1:3-4,1984
Liou, S., and Ren, J.  1984. toxicity and teratogenicity studies of arsenite in
Zhonghua Laodong Weisheng Zhiyebing Zazhi (Chinese JInd Hyg Occupat
Wang, C., Gomer, R. H., and Lazarides, E.  1981. heat shock proteins are methylated in avian and
mammalian cells.  Proceedings of the National Academy of Sciences of the United States of

Wang, C., Lin, J. M., and Lazarides, E.  1992.  methylations of 70,000-da heat shock proteins in
3t3 cells: alterations by arsenite treatment, by different stages of growth and by virus
transformation.   Archives of Biochemistry and Biophysics  297(1):  169-75.

Wang, T. C., Huang, J. S.,  Yang, V. C., Lan, H. J., Lin, C. J., and Jan, K. Y. delay of the excision
of uv light-induced dna adducts is involved in the coclastogenicity of uv light plus arsenite.
International Journal of Radiation Biology; 66(4). 1994. 367-372.

Wang, T. S., Kuo, C. F., Jan, K. Y., and Huang, H. 1996. arsenite induces apoptosis in Chinese
hamster ovary cells by generation of reactive oxygen species.  Journal of Cellular Physiology;
169 (2). 1996. 256-268.

Wang, T. S., Shu, Y. F., Liu, Y. C., Jan, K. Y., and Huang, H.   1997. glutathione peroxidase and
catalase modulate the genotoxicity of arsenite.   Toxicology; 121 (3). 1997. 229-237.

Warren, A. P. and Pasternak, C. A.  1988. common pathway for the induction of hexose transport
by insulin and Stress.   J Cell Physiol; 138 (2). 1988. 323-328.
Eco-SSLfor Arsenic
                                   103
                                                          March 2005

-------
In Vit          Wasserman, R. H.  1979.  Molecular Mechanisms of the Epithelial Transport of Toxic Metal Ions,
                Particularly Mercury, Cadmium, Lead, Arsenic, Zinc, and Copper. Progress Report, January 1,
                1979-December31, 1979

In Vit          Wasserman, R. H. and Fullmer, C. S.  19&6.Molecular Mechanisms of the Epithelial Transport of
                Toxic Metal Ions. Final Report, September 1, 1975-December 31, 1985.  DOE/EV/02792-12

Diss            Watanabe, T., Hirayama, T., Takahashi, T., Kokubo, T., and Ikeda, M. lexicological evaluation of
                arsenic in edible seaweed, hizikia.

CP             Watanabe, T., Hirayama, T., Takahashi, T., Kokubo, T., and Ikeda, M.  1980.  lexicological
                evaluation of arsenic in edible seaweed hizikia species.   2nd International Congress on
                Toxicology

Aquatic        Watanabe, Takao, Hirayama, Toshiko, Takahashi, Torn, Kokubo, Takeshi, and Ikeda, Masayuki.
                1979.  toxicological evaluation of arsenic in edible seaweed, hizikia species.  Toxicology (1979)
                14(1):  1-22.

Unrel          Watson, A. P. and Griffin, G. D.  1992.  toxicity of vesicant agents scheduled for destruction by
                the chemical stockpile disposal program.  Environmental Health Perspectives 98: 259-80.

No Oral        Webb, D. R., Wilson, S. E., and Carter, D. E.  1987.  pulmonary clearance and toxicity of
                respirable gallium arsenide particulates intratracheally instilled into  rats. Am. Ind. Hyg. Assoc.
                J.  (1987)  48(7): 660-7.

Unrel          Westing, T.  W., Fontenot, J. P., McClure, W. H., Kelly, R. F., and Webb, K. E. Jr.  1985.
                characterization of mineral element profiles in animal waste andtissues from cattle fed animal
                waste.  1. heifers fed broiler litter.  Journal of Animal Science  61(3): 670-681.

Nut Def        Whanger, P. D., Weswig, P. H., Schmitz, J. A., and Oldfield, J.  E. 1976.  effects of selenium,
                cadmium, mercury, tellurium, arsenic, silver and arsenic on white muscle disease in lambs and
                effect of dietary forms of arsenic on its accumulation in tissues.   NutrRepInt. 14(1): 63-72.

Unrel          Wharton, R. H., Roulston, W. J., and  Wells, E. A.  1977. acaricide  resistance in
                boophilus microplus in australia.    73-92.

Surv            White, D. H., King, K. A., and Prouty, R. M.  1980.  significance of organochlorine and heavy
                metal residues in wintering shorebirds at corpus christi, texas, 1976-77.  Pestic. Monit. J.  14(2):
                58-63.
In Vit
In Vit
Surv
 Wiegant, F. A., van Bergen en Henegouwen, P. M., van Dongen, G., and Linnemans, W. A.
1987. stress-induced thermotolerance of the cytoskeleton of mouse neuroblastoma n2a cells and
rat reuberh35 hepato ma cells.  Cancer Research  47(6):  1674-80.

 Wiegant, F. A. C., Souren, J. E. M., van Rijn, J., and van Wijk, R.  stressor-specific induction of
heat shock proteins in  rat hepatoma cells.  Toxicology (1994)   94(1-3):  143-59.

Wiemeyer,  S. N., Jurek, R. M., and Moore, J. F.  1986. environmental contaminants in surrogates
foods and feathers of California condors gymnogyps-californianus.   Environ Monit Assess.  6(1):
Surv
Wiemeyer, Stanley N., Schmeling, Sheila K., and Anderson, Allen.  1987.  environmental
Eco-SSLfor Arsenic
                                   104
March 2005

-------
                pollutant and necropsy data for ospreys from the eastern united states, 1975-1982.  J. Wildl. Dis.
                23(2):  279-91  .

No Oral        Wight, P. A. L., Dewar, W. A., Saunderson, C. L., Wiemeyer, S. N., Jurek, R. M, and Moore, J.
                F. 1986. zinc  toxicity in the fowl ultrastructural pathology and relationship to selenium lead and
                copper: environmental contaminants in surrogates foods and feathers of California condors
                Gymnogyps-californianus.  Avian Pathol. 15(1):  23-38.

Rev            Wilber, C. G.  1980. toxicology  of selenium: a review.  Clin.  Toxicol.  17(2): 171-230.

No Oral         Wilkinson, F.  C.  1979.  dermatophilosis of sheep association with dipping and effects
                onproduction.  Australian Veterinary Journal 55(2):  74-76.

Gene           Willems, F., Vansanten-Urbain, G., De Wit, D., Slaoui, M., and Urbain, J. 1990. loss of a major
                idiotype (cria)  after repopulation of irradiated mice.  Journal of Immunology  144(4): 1396-403.

No Oral        Willhite, C. C. arsenic-induced axial skeletal (dysraphic) Disorders.  Exp Mol Pathol 34:145-
                158,1981
Rev
Sed
Williams, S. N. and McDowell, L. R.  1985.  newly discovered and toxic elements.  Animal
Feeding and Nutrition: Nutrition of Grazing Ruminants in Warm Climates.   317-338.

Winger, P. V., Lasier, P. J., White, D. H., and Seginak, J. T.  2000.  effects of contaminants in
dredge material from the lower savannah river .  Arch. Environ. Contam. Toxicol.  38(1):  128-
136.
Surv           Winger, P. V(A), Lasier, P. J., White, D. H., and Seginak, J. T. 2000. effects of contaminants in
                dredge material from the lower savannah river.  Archives of Environmental Contamination and
                Toxicology  38(1): 128-136.

Org met        Wise, D. R., Hartley, W. J., and Fowler, N. G.  1974. pathology of 3-nitro-4-
                hydroxyphenylarsonic acid toxicity in turkeys.  Research in Veterinary Science  16(No.3): 336-
                340.

Abstract        Woods, J. S. and Fowler, B.  A. 1978. perturbation of hepatic heme biosynthesis and urinary
                porphyrin levels as an early response to prolonged arsenic exposure.   Society of Toxicology
                Seventeenth Annual Meeting: Abstracts of Papers. In Toxicology and Applied Pharmacology
                45(1):  309.

Dup            Woods, JS and Fowler, BA.   1977. effects of chronic arsenic exposure on hematopoietic function
                in adult mammalian liver.  Environ. Health. Perspect.  19:  209-213.

Org met        Worden, An and Wood, EC.  1973. the effect of carbarsone (33.6% w/v p-ureidobenzene arsonic
                acid) on bodyweight gain, food conversion and tissue arsenic levels of turkey poults.  J. Sci. Food
                Agric.  24: 35-41  .

Unrel           Xu, Xiuju, Xiao, Menglan, Li, Feng, Wang, Xiaoning, and Li, Meixian. nutritional and safety
                evaluation of delipidized castor bean proteins.  Shipin Kexue (Beijing) (1990)  : 122, 8-9

Mix            Yanaga, Makoto, Enomoto, Shuichi, Hirunuma, Rieko, Endo, Kazutoyo, Ambe, Shizuko, Tozawa,
                Machiko, and Ambe, Fumitoshi.  1966. uptake and excretion of various elements in rats.   RIKEN
                Rev.   13, 23-24 .
Eco-SSLfor Arsenic
                                   105
March 2005

-------
Mix            Yanaga, Makoto, Enomoto, Shuichi, Hirunuma, Rieko, Furuta, Riko, Endo, Kazutoyo, Tanaka,
                Akira, Ambe, Shizuko, Tozawa, Machiko, and Ambe, Fumitoshi.  multitracer study on uptake and
                excretion of trace elements in rats.  Appl. Radial. Isot. (1996)  47(2): 235-40 .

Acu            Yanez, Leticia, Carrizales, Leticia, Zanatta, Maria Teresa, De Jesus Mejia, Jose, Batres, Lilia, and
                Diaz-Barriga, Fernando,  arsenic-cadmium interaction in  rats : toxic effects in the heart and
                tissue metal shifts.   Toxicology (1991)  67(2): 227-34.

FL              Yang, J. G., Zhou, L., and Liu, M. X. 1989.  [antidotal effect ofStenoloma chusanum(l.) ching
                against arsenic and ammonium].  Chung-Kuo Chung Yao Tsa Chih   14(3):  46-8, 64.

In Vit          Yang, J. L., Chen, M. F., Wu, C. W., and Lee, T.  C.  1992. posttreatment with sodium arsenite
                alters the mutational spectrum induced by ultraviolet light irradiation in Chinese hamster ovary
                cells.  Environmental and Molecular Mutagenesis  20(3): 156-64.

No Oral        Yang, Y. L., Lu, K. T., Tsay, H. J., Lin, C. H., and Lin, M. T.  1998. heat shock protein
                expression protects against death following exposure to heatstroke in rats.  Neuroscience Letters
                252(1):  9-12.

Aquatic        Yannai, S., Mokady, S., Sachs,  K., Kantorowitz, B., and Berk, Z.  1979.  secondary toxicology and
                contaminants of algae grown on waste water.   Nutrition Reports International.  19 (3): 391-400.

FL             Yao, H. and Wang, G. Q.  1988. [experimental studies on the acute and chronic combined action
                of arsenic and fluoride].   Chung-Hua Yu Fang i Hsueh Tsa Chih  22( 5): 284-6.

In Vit          YIH, L. H. and Lee, T. C.  1994.  a proteolytic activity enhanced by arsenite in Chinese hamster
                ovary cells: possible involvement in arsenite-induced cell killing.  Biochemical and Biophysical
                Research Communications; 202 (2). 1994. 1015-1022.

Acute          Yoshida, K, Chen, H, Inoue, Y, Wanibuchi, H, Fukushima, S, Kuroda, K, and Endo, G.  1997.
                the urinary excretion of asenic metabolites after a single oral administration of dimethylarsinic acid
                to rats.  Arch Environ Contam Toxicol.  32(4): 416-421.

Org met        Yoshida, Kaoru, Inoue, Yoshinori, Kuroda, Koichi, Chen, Hua, Wanibuchi, Hideki, Fukushima,
                Shoji, and Endo, Ginji.  1998. urinary excretion of arsenic metabolites after long-term oral
                administration of various arsenic compounds to  rats.  J.  Toxicol. Environ. Health Part A . 54(3):
                179-192

Acu            Yoshikawa, Hiroshi. preventive effect of pretreatment with low dose of metals on the acute
                toxicity of metals in mice.   Ind. Health (1970)  8(4):  184-91.

Unrel          Yotis William W(A), Gopalsami Chellam, Corrigan Kevin, Hoerman Kirk, and Keene Joseph J Jr.
                1993. phosphorylated nutrient uptake by treponema denticola and other potential
                periodontopathogens.  Journal of Basic Microbiology  33(5): 357-368.

Org met        Young, R. A., Opresko, D. M.,  Watson, A. P., and King, J. preliminary data analysis and
                derivation of an estimated reference dose (rfde) for lewisite.  Toxicologist 1996Mar;30(1 Pt
                2): 149

Unrel          Yu, Ping, Yan, Jinling, and Huang, Meng. extraction of the active constituents of fugus ovary and
                their properties.  Tianran Chanwu  Yanjiu Yu Kaifa (1999)  11(5): 51-54.
Eco-SSLfor Arsenic
106
March 2005

-------
FL
Prim
Prim
Yuan, Hongbing and Zhang, Gong,  combined effects of lead, cadmium and arsenic on renal trace
element levels in  mice.   Gongye Weisheng Yu Zhiyebing (1991)   17(2):  70-2 .

Zakharyan, R. A., Wildfang, E., and Aposhian, H. V.  1996.  enzymatic methylation of arsenic
compounds, iii. the marmoset and tamarin, but not the rhesus, monkeys are deficient in
methyltransferases that methylate inorganic arsenic.   Toxicology and Applied Pharmacology
140(1):  77-84.

Zakharyan, Robert A., Wildfang, Eric, and Aposhian, H. Vasken. enzymic methylation of arsenic
compounds, iii. the marmoset and tamarin, but not the rhesus, monkeys  are deficient in
methyltransferases that methylate inorganic arsenic.   Toxicol. Appl. Pharmacol. (1996)  140(1):
77-84.
Acute          Zaman, K and Pardini, RS. 1995. an insect model for assessing toxicity: arsenic elevated
                glutathione content in the musca domestica and trichoplusia ni.  Bull Environ Contam Toxicol.
                55(6):  845-852.

No Org         Zaman, Khalequz, MacGill, Randall S., Johnson, James E., Ahmad, Sami, and Pardini, Ronald S.
                an insect model for assessing oxidative stress related to arsenic toxicity.  Arch. Insect Biochem.
                Physiol. (1995)  29(2): 199-209..

Unrel          Zeledon, R. and De Monge, E.  1967.  physiological studies on the culture form of four strains of
                leishmania braziliensis. i. nitrogen content, substrate utilization, and effect of metabolic inhibitors
                on respiration and its relation to infectivity.   Journal of Parasitology  53(5): 937-45.

Mix            Zhai, CK, Tang, WL, Jang, XL, and Lorenz, KJ. 1996. studies of the safety of Chinese wild rice.
                Food Chem Toxicol. 34: 347-352.

FL             Zhang, C., Yao, H., Ling, B., and Liu, J. 1997.  [the effect of arsenic on reproduction and
                offspring development of rats].   Wei Sheng Yen Chiu  26(3):  179-82.

FL             Zhang, Chen, Ling, Bing, Liu, Jiwen, Wang, Guoquan, and Xiao, Biyu. effect of fluoride-arsenic
                exposure on neurobehavioral development  of off springs in  rats.  Weisheng Yanjiu (1999)
                28(6):  337-338, C4.

FL             Zhang, Chen, Yao, Hua, Ling, Bing, and Liu, Jiwen. accumulative arsenic level in viscera in
                offsprings of exposed parent rats.  Zhonghua Yufang Yixue Zazhi (1998)  32(2): 76-78.

FL             Zhang, Cheng, Yao, Hua, Lin, Bin, Liu, Jiwen, and Jiang, Ping, arsenic exposed rat offspring
                mutagenicity  study.   Weisheng Dulixue Zazhi (1998)  12(1): 33-34.

Chem Meth     Zinke-Allmang, M, Feldman, L. C., Patel, J. R., and Tully, J. C.  The Morphology of Arsenic
                Terminated Silicon(l 11)  from Desorption Kinetics.  Surf. Sci. (1988)  197(1-2): 1-10.

FL             Zmudzki, J. and Szkoda,  J. Trace Elements Content of Hen Eggs in Poland.  Bromatologia I
                Chemia Toksykologiczna; 29 (1). 1996. 55-57.
Eco-SSLfor Arsenic
                                   107
March 2005

-------
Literature Rejection Categories
Rejection Criteria
ABSTRACT
(Abstract)
ACUTE STUDIES
(Acu)
AIR POLLUTION
(AirP)
ALTERED RECEPTOR
(Alt)
AQUATIC STUDIES
(Aquatic)
ANATOMICAL STUDIES
(Anat)
BACTERIA
(Bact)
BIOACCUMULATION
SURVEY
(Bio Ace)
BIOLOGICAL PRODUCT
(BioP)
BIOMARKER
(Biom)
CARCINOGENICITY
STUDIES
(Carcin)
CHEMICAL METHODS
(Chem Meth)
CONFERENCE
PROCEEDINGS
(CP)
DEAD
(Dead)
DISSERTATIONS
(Diss)
DRUG
(Drug)
DUPLICATE DATA
(Dup)
Description
Abstracts of journal publications or conference
presentations.
Single oral dose or exposure duration of three days or less.
Studies describing the results for air pollution studies.
Studies that describe the effects of the contaminant on
surgically-altered or chemically -modified receptors (e.g.,
right nephrectomy, left renal artery ligature, hormone
implant, etc.).
Studies that investigate toxicity in aquatic organisms.
Studies of anatomy. Instance where the contaminant is
used in physical studies (e.g., silver nitrate staining for
histology).
Studies on bacteria or susceptibility to bacterial infection.
Studies reporting the measurement of the concentration of
the contaminant in tissues.
Studies of biological toxicants, including venoms, fungal
toxins, Bacillus thuringiensis, other plant, animal, or
microbial extracts or toxins.
Studies reporting results for a biomarker having no
reported association with an adverse effect and an
exposure dose (or concentration).
Studies that report data only for carcinogenic endpoints
such as tumor induction. Papers that report systemic
toxicity data are retained for coding of appropriate
endpoints.
Studies reporting methods for determination of
contaminants, purification of chemicals, etc. Studies
describing the preparation and analysis of the contaminant
in the tissues of the receptor.
Studies reported in conference and symposium
proceedings.
Studies reporting results for dead organisms. Studies
reporting field mortalities with necropsy data where it is
not possible to establish the dose to the organism.
Dissertations are excluded. However, dissertations are
flagged for possible future use.
Studies reporting results for testing of drug and therapeutic
effects and side-effects. Therapeutic drugs include
vitamins and minerals. Studies of some minerals may be
included if there is potential for adverse effects.
Studies reporting results that are duplicated in a separate
publication. The publication with the earlier year is used.
Receptor
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates

-------
Literature Rejection Categories
Rejection Criteria
ECOLOGICAL
INTERACTIONS
(Ecol)
EFFLUENT
(Effl)
ECOLOGICALLY
RELEVANT ENDPOINT
(ERE)
CONTAMINANT
FATE/METABOLISM
(Fate)
FOREIGN LANGUAGE
(FL)
FOOD STUDIES
(Food)
FUNGUS
(Fungus)
GENE
(Gene)
HUMAN HEALTH
(HHE)
IMMUNOLOGY
(IMM)
INVERTEBRATE
(Invert)
IN VITRO
(In Vit)
LEAD SHOT
(Lead shot)
MEDIA
(Media)
METHODS
(Meth)
MINERAL REQUIREMENTS
(Mineral)
MIXTURE
(Mix)
Description
Studies of ecological processes that do not investigate
effects of contaminant exposure (e.g., studies of "silver"
fox natural history; studies on ferrets identified in iron
search).
Studies reporting effects of effluent, sewage, or polluted
runoff.
Studies reporting a result for endpoints considered as
ecologically relevant but is not used for deriving Eco-SSLs
(e.g., behavior, mortality).
Studies reporting what happens to the contaminant, rather
than what happens to the organism. Studies describing the
intermediary metabolism of the contaminant (e.g.,
radioactive tracer studies) without description of adverse
effects.
Studies in languages other than English.
Food science studies conducted to improve production of
food for human consumption.
Studies on fungus.
Studies of genotoxicity (chromosomal aberrations and
mutagenicity).
Studies with human subjects.
Studies on the effects of contaminants on immuno logical
endpoints.
Studies that investigate the effects of contaminants on
terrestrial invertebrates are excluded.
In vitro studies, including exposure of cell cultures,
excised tissues and/or excised organs.
Studies administering lead shot as the exposure form.
These studies are labeled separately for possible later
retrieval and review.
Authors must report that the study was conducted using
natural or artificial soil. Studies conducted in pore water or
any other aqueous phase (e.g., hydroponic solution), filter
paper, petri dishes, manure, organic or histosoils (e.g., peat
muck, humus), are not considered suitable for use in
defining soil screening levels.
Studies reporting methods or methods development
without usable toxicity test results for specific endpoints.
Studies examining the minerals required for better
production of animals for human consumption, unless
there is potential for adverse effects.
Studies that report data for combinations of single
toxicants (e.g. cadmium and copper) are excluded.
Exposure in a field setting from contaminated natural soils
or waste application to soil may be coded as Field Survey.
Receptor
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates

-------
Literature Rejection Categories
Rejection Criteria
MODELING
(Model)
NO CONTAMINANT OF
CONCERN
(No COC)
NO CONTROL
(No Control)
NO DATA
(No Data)
NO DOSE or CONC
(No Dose)
NO DURATION
(No Dur)
NO EFFECT
(No Efct)
NO ORAL
(No Oral)
NO ORGANISM
(No Org) or NO SPECIES
NOT AVAILABLE
(Not Avail)
NOT PRIMARY
(Not Prim)
NO TOXICANT
(No Tox)
NO TOX DATA
(No Tox Data)
NUTRIENT
(Nutrient)
NUTRIENT DEFICIENCY
(Nut def)
NUTRITION
(Nut)
OTHER AMBIENT
CONDITIONS
(OAC)
Description
Studies reporting the use of existing data for modeling,
i.e., no new organism toxicity data are reported. Studies
which extrapolate effects based on known relationships
between parameters and adverse effects.
Studies that do not examine the toxicity of Eco-SSL
contaminants of concern.
Studies which lack a control or which have a control that is
classified as invalid for derivation of TRVs.
Studies for which results are stated in text but no data is
provided. Also refers to studies with insufficient data
where results are reported for only one organism per
exposure concentration or dose (wildlife).
Studies with no usable dose or concentration reported, or
an insufficient number of doses/concentrations are used
based on Eco-SSL SOPs. These are usually identified
after examination of full paper. This includes studies
which examine effects after exposure to contaminant
ceases. This also includes studies where offspring are
exposed in utero and/or lactation by doses to parents and
then after weaning to similar concentrations as their
parents. Dose cannot be determined.
Studies with no exposure duration. These are usually
identified after examination of full paper.
Studies with no relevant effect evaluated in a biological
test species or data not reported for effect discussed.
Studies using non-oral routes of contaminant
administration including intraperitoneal injection, other
injection, inhalation, and dermal exposures.
Studies that do not examine or test a viable organism (also
see in vitro rejection category).
Papers that could not be located. Citation from electronic
searches may be incorrect or the source is not readily
available.
Papers that are not the original compilation and/or
publication of the experimental data.
No toxicant used. Publications often report responses to
changes in water or soil chemistry variables, e.g., pH or
temperature. Such publications are not included.
Studies where toxicant used but no results reported that
had a negative impact (plants and soil invertebrates).
Nutrition studies reporting no concentration related
negative impact.
Studies of the effects of nutrient deficiencies. Nutritional
deficient diet is identified by the author. If reviewer is
uncertain then the administrator should be consulted.
Effects associated with added nutrients are coded.
Studies examining the best or minimum level of a
chemical in the diet for improvement of health or
maintenance of animals in captivity.
Studies which examine other ambient conditions: pH,
salinity, DO, UV, radiation, etc.
Receptor
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Plants and Soil Invertebrates
Plants and Soil Invertebrates
Wildlife
Wildlife
Wildlife
Plants and Soil Invertebrates

-------
Literature Rejection Categories
Rejection Criteria
OIL
(Oil)
OM,pH
(OM, pH)
ORGANIC METAL
(Org Met)
LEAD BEHAVIOR OR HIGH
DOSE MODELS
(Pb Behav)
PHYSIOLOGY STUDIES
(Phys)
PLANT
(Plant)
PRIMATE
(Prim)
PUBLAS
(Publ as)
QSAR
(QSAR)
REGULATIONS
(Reg)
REVIEW
(Rev)
Description
Studies which examine the effects of oil and petroleum
products.
Organic matter content of the test soil must be reported by
the authors, but may be presented in one of the following
ways; total organic carbon (TOC), particulate organic
carbon (POC), organic carbon (OC), coarse particulate
organic matter (CPOM), particulate organic matter (POM),
ash free dry weight of soil, ash free dry mass of soil,
percent organic matter, percent peat, loss on ignition
(LOI), organic matter content (OMC).
With the exception of studies on non-ionizing substances,
the study must report the pH of the soil, and the soil pH
should be within the range of >4 and <8.5. Studies that
do not report pH or report pH outside this range are
rejected.
Studies which examine the effects of organic metals. This
includes tetraethyl lead, triethyl lead, chromium
picolinate, phenylarsonic acid, roxarsone, 3-nitro-4-
phenylarsonic acid,, zinc phosphide, monomethylarsonic
acid (MMA), dimethylarsinic acid (DMA), trimethylarsine
oxide (TMAO), or arsenobetaine (AsBe) and other organo
metallic fungicides. Metal acetates and methionines are
not rejected and are evaluated.
There are a high number of studies in the literature that
expose rats or mice to high concentrations of lead in
drinking water (0.1, 1 to 2% solutions) and then observe
behavior in offspring, and/or pathology changes in the
brain of the exposed dam and/or the progeny. Only a
representative subset of these studies were coded.
Behavior studies examining complex behavior (learned
tasks) were also not coded.
Physiology studies where adverse effects are not
associated with exposure to contaminants of concern.
Studies of terrestrial plants are excluded.
Primate studies are excluded.
The author states that the information in this report has
been published in another source. Data are recorded from
only one source. The secondary citation is noted as Publ
As.
Derivation of Quantitative Structure- Activity
Relationships (QSAR) is a form of modeling. QSAR
publications are rejected if raw toxicity data are not
reported or if the toxicity data are published elsewhere as
original data.
Regulations and related publications that are not a primary
source of data.
Studies in which the data reported in the article are not
primary data from research conducted by the author. The
publication is a compilation of data published elsewhere.
These publications are reviewed manually to identify other
relevant literature.
Receptor
Wildlife
Plants and Soil Invertebrates
Plants and Soil Invertebrates
Wildlife
Wildlife
Wildlife
Wildlife
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates

-------
Literature Rejection Categories
Rejection Criteria
SEDIMENT CONC
(Sed)
SCORE
(Score)
SEDIMENT CONC
(Sed)
SLUDGE
SOIL CONC
(Soil)
SPECIES
STRESSOR
(QAC)
SURVEY
(Surv)
REPTILE OR AMPHIBIAN
(Herp)
UNRELATED
(Unrel)
WATER QUALITY STUDY
(Wqual)
YEAST
(Yeast)
Description
Studies in which the only exposure concentration/dose
reported is for the level of a toxicant in sediment.
Papers in which all studies had data evaluation scores at or
lower then the acceptable cut-off (_s 10 of 18) for plants
and soil invertebrates).
Studies in which the only exposure concentration/dose
reported is for the level of a toxicant in sediment.
Studies on the effects of ingestion of soils amended with
sewage sludge.
Studies in which the only exposure concentration/dose
reported is for the level of a toxicant in soil.
Studies in which the species of concern was not a
terrestrial invertebrate or plant or mammal or bird.
Studies examining the interaction of a stressor (e.g.,
radiation, heat, etc.) and the contaminant, where the effect
of the contaminant alone cannot be isolated.
Studies reporting the toxicity of a contaminant in the field
over a period of time. Often neither a duration nor an
exposure concentration is reported.
Studies on reptiles and amphibians. These papers flagged
for possible later review.
Studies that are unrelated to contaminant exposure and
response and/or the receptor groups of interest.
Studies of water quality.
Studies of yeast.
Receptor
Wildlife
Plants and Soil Invertebrates
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates
Wildlife
Wildlife
Plants and Soil Invertebrates
Wildlife
Plants and Soil Invertebrates

-------
This Page Intentionally Left Blank

-------
m
                SSL
Appendix 5-1
Avian Toxicity Data Extracted and Reviewed for Wildlife Toxicity
Reference Value (TRY) -Arsenic	
March 2005

-------
This page intentionally left blank

-------
                                                          Appendix 5.1 Avian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                                                                      Arsenic
                                                                                                    Page 1 of 1
Ref
Result #
2;
1

Reference
Exposure
Chemical Form
£
Q
*s
s.
CO
%
Phase #
# of Cone/ Doses
Cone/ Doses
Cone/Dose Units
Wet Weight Reported?
Percent Moisture
Application Frequency
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
Q
*
Age Units
Lifestage
X
£

Control Type

Test Location


Effects
General Effect Group
Effect Type
Effect Measure
Response Site
Study NOAEL
Study LOAEL
Conversion to mg/kg bw/day
Body Weight Reported?
Body Weight in kg
Ingestion Rate Reported?
Ingestion Rate in kg/day or
L/day
Result
NOAEL Dose (mg/kg/day)
LOAEL Dose (mg/kg/day)
Data Evaluation Score
Data Source
Dose Route
Test Concentrations
Chemical form
Dose Quantification
Endpoint
Dose Range
Statistical Power
Exposure Duration
Test Conditions
1
Biochemical
1
2
5747
1376
Camardese et al, 1990
Hoffman et al, 1992
Sodium arsenate
Sodium arsenate
100
100
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
1
1
4
2
0/30/100/300
0/200
mg/kg diet
mg/kg diet
Y
N
12.1
6
ADL
ADL
UX
ux
FD
FD
10
4
w
w
1
1
d
d
JV
JV
F
B
C
C
FieldA
FieldA
5
4
BIO
BIO
ENZ
ENZ
ACHE
GLPX
BR
PL


30.0
200
Y
N
1.0
0.384
Y
N
0.012
0.03121


0.410
17.3
10
10
10
10
10
10
10
10
7
5
1
1
4
4
10
10
10
10
4
4
76
74
Behavior
5
3
4
5747
5305
5690
Camardese et al, 1990
Holcman and Stibilj, 1997
Whitworth et al 1991
Sodium arsenate
Arsenic oxide
Sodium arsenate
100
100
100
Mallard duck (Anas platyrhynchos )
Chicken (Callus domesticus )
Mallard duck (Anas platyrhynchos )
1
1
1
4
4
4
0/30/100/300
0/7.5/15.0/30.0
0/30/100/300
mg/kg diet
mg/kg diet
mg/kg diet
Y
N
Y
12.1
na
12.1
ADL
NR
ADL
UX
u
u
FD
FD
FD
2
19
9
w
d
w
1
49
1
d
w
d
JV
SM
JV
F
F
NR
C
C
C
FieldA
Lab
Lab
4
1
1
BEH
BEH
BEH
FOB
FOB
BEH
FCNS
FCNS
ACTV
WO
WO
wo
30.0
30.0
100
100.0

300
Y
N
N
0.160
1.6
0.092
Y
Y
N
0.007
0.1194
0.01231
1.49
2.24
15.2
4.98

45.7
10
10
10
10
10
10
10
5
5
10
10
10
7
6
5
4
4
4
8
4
10
10
8
10
10
6
10
4
4
4
83
67
78
Pathology
6
7
5747
1376
Camardese et al, 1990
Hoffman et al, 1992
Sodium arsenate
Sodium arsenate
100
100
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
1
1
4
2
0/30/100/300
0/200
mg/kg diet
mg/kg diet
Y
N
12.1
6
ADL
ADL
ux
ux
FD
FD
10
4
w
w
1
1
d
d
JV
JV
B
B
C
C
FieldA
FieldA
3
3
PTH
PTH
ORW
ORW
ORWT
ORWT
LI
LI
300


200
Y
N
1.10
0.384
Y
N
0.012
0.03121
3.72


17.3
10
10
10
10
10
10
10
10
7
5
4
4
4
4
1
10
10
10
4
4
70
77
Reproduction
8
5305 |Holcman and Stibilj, 1997 |Arsenic oxide
100 |Chicken (Callus domesticus )
1
4 |o/7.5/15.0/30.0 |mg/kg diet
N
na
NR
u |FD
19
d
49
w
LB
F
C
Lab | 3 | REP
REP
PROG
WO
30.0

N
1.6
Y
0.1194
2.24

10
10
5
10
6
10
4
3
10
4
72
Growth
9
10
11
12
5305
5747
1387
1376
Holcman and Stibilj, 1997
Camardese et al, 1990
Howell and Hill, 1978
Hoffman et al, 1992
Arsenic oxide
Sodium arsenate
Arsenic trichloride
Sodium arsenate
100
100
100
100
Chicken (Callus domesticus )
Mallard duck (Anas platyrhynchos )
Chicken (Callus domesticus )
Mallard duck (Anas platyrhynchos )
1
1
1
1
4
4
2
2
0/7.5/15.0/30.0
0/30/100/300
0/50
0/200
mg/kg diet
mg/kg diet
mg/kg diet
mg/kg diet
N
Y
N
N
na
12.1
na
6
NR
ADL
ADL
ADL
u
ux
u
ux
FD
FD
FD
FD
19
2
21
4
d
w
d
w
49
1
1
1
w
d
d
d
SM
JV
JV
JV
F
F
B
B
C
C
C
C
Lab
FieldA
Lab
FieldA
2
2
1
2
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
BDWT
GGRO
BDWT
BDWT
WO
wo
wo
wo
30.0




30.0
50.0
200
N
Y
N
Y
1.6
0.160
0.564
0.384
Y
Y
N
N
0.1194
0.007
0.04009
0.03121
2.24




1.49
3.55
17.3
10
10
10
10
10
10
10
10
5
10
5
10
10
10
10
10
6
7
5
6
8
8
8
8
4
4
4
4
3
10
10
10
6
10
10
10
4
4
4
4
66
83
76
82
Survival
13
14
15
16
5305
1387
5747
1376
Holcman and Stibilj, 1997
Howell and Hill, 1978
Camardese et al, 1990
Hoffman et al, 1992
Arsenic oxide
Arsenic trichloride
Sodium arsenate
Sodium arsenate
100
100
100
100
Chicken (Callus domesticus )
Chicken (Callus domesticus )
Mallard duck (Anas platyrhynchos )
Mallard duck (Anas platyrhynchos )
1
1
1
1
4
2
4
2
0/7.5/15.0/30.0
0/50
0/30/100/300
0/200
mg/kg diet
mg/kg diet
mg/kg diet
mg/kg diet
N
N
Y
N
na
na
12.1
6
NR
ADL
ADL
ADL
u
u
ux
ux
FD
FD
FD
FD
19
21
10
4
d
d
w
w
49
1
1
1
w
d
d
d
SM
JV
JV
JV
F
B
B
B
C
C
C
C
Lab
Lab
FieldA
FieldA
4
2
3
1
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MORT
MORT
MORT
SURV
wo
wo
wo
wo
30.0
50.0
300
200




N
N
Y
Y
1.6
0.564
1.10
0.384
Y
N
Y
N
0.1194
0.04009
0.012
0.03121
2.24
3.55
3.72
17.3




10
10
10
10
10
10
10
10
5
5
10
10
10
10
10
10
6
5
7
6
9
9
9
9
4
4
4
4
10
10
10
10
6
10
10
10
4
4
4
4
74
77
84
83
 ailable from Attachment 4-3 of the Eco-SSL guidance (U.S. EPA 2003).
Eco-SSL for A rsenic
March 2005

-------

-------
               Soil Sorooning M>v«l«
Appendix 6-1
Mammalian Toxicity Data Extracted and Reviewed for Wildlife
Toxicity Reference Value (TR V) - Arsenic
March 2005

-------
This page intentionally left blank

-------
                                                         Appendix 6.1  Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                                                                   Arsenic
                                                                                                 Page 1 of 4
Ref
Result #
Z;
1

c
1
Exposure
S
1
1
g
u
6
SS
^
.1
1
«
H
Phase #
# of Cone/ Doses
1
o
Q
1
o
O
Cone/Dose Units
Wet Weight Reported?
Percent Moisture
Application Frequency
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
&
•3
Age Units
Lifestage
x
<2

Control Type

o
H
Effects
General Effect Group
Effect Type
3
S
^
Response Site
J
H
|
^1
i
s
Conversion to mg/kg bw/day
Study LOAEL
Body Weight Reported?
Body Weight in kg
Ingestion Rate Reported?
Ingestion Rate in kg or L/day
Result
NOAELDose (mg/kg/day)
LOAEL Dose (mg/kg/day)
Data Evaluation Score
Data Source
Dose Route
Test Concentrations
Chemical form
Dose Quantification
Endpoint
Dose Range
Statistical Power
Exposure Duration
Test Conditions
3
o
H
Biochemical
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
14583
15703
15387
14580
15011
14577
15506
15216
14546
14546
15216
11361
15387
15709
25916
15322
15530
14590
15530
Neiger and Osweiler 1989
Neiger and Osweiler, 1992
Wood and Fowler, 1978
Mahaffey et al., 1977
Ghosh et all 999
Itohetal., 1990
Schroeder, 1968
Nagaraja andDesiraju, 1994
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Nagaraja andDesiraju, 1994
Glattreet. al., 1995
Wood and Fowler, 1978
Morrison and Chavez, 1983
Biswas, et al, 2000
Biswas etal, 1998
Garcia- Vargas et al, 1995
Tnpathietal 1997
Garcia- Vargas et al, 1995
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenite
Arsenic trioxide
Sodium arsenite
Sodium arsenate
Arsenic
Sodium arsenate
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenate
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
57.69
56.79
100
100
57.69
83.53
100
100
100
100
100
100
100
100
57.69
57.69
100
100
100
Dog (Canis familiaris~)
Dog (Cams familiaris~)
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Mouse (Mus musculus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus }
Rat (Rattus norvegicus}
Mouse (Mus musculus)
Pig (Sus scrofa }
Goat (Ovis aries}
Goat (Capra hircus}
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Mouse (Mus musculus }
1
1
1
1
1
1
1
1
2
1
2
i
2





2
4
4
4
2
3
3
2
2
2
2
2
2
4
2
2
2
2
2
2
0.0/0.88/1.80/2.88
0.0/0.88/1.80/2.88
0/1.2/2.2/3.5
0/50
0/0.2/0.4
0/3/10
0/3.776
0/5
0/5
0/5
0/5
0/6.36
0/6.6/11.4/25.1
0/100
0/25
0/25.0
0/20
0/2.56
0/50
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg diet
mg/org/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg diet
mg/kg bw/d
mg/kg bw/d
mg/L
mg/org/d
mg/L
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
Y
na
na
na
na
na
na
na
na
na
na
na
na
na
na

na

na

DLY
DLY
NR
ADL
DLY
DLY
ADL
DLY
DLY
DLY
DLY
ADL
NR
ADL
DLY
ADL
ADL
ADL
ADL
U
M
U
UX
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
FD
FD
DR
FD
GV
OR
DR
GV
FD
GV
FD
DR
DR
FD
OR
DR
DR
DR
DR
8
58
6
10
28
14
781
20
90
18
90
4
6
2
3
6
2
16
2
w
d
w
w
d
d
d
d
d
d
d
w
w
w
w
w
w
w
w
8
8
NR
NR
35
4
21-23
2
90
2
90
NR
NR
21
12
1
NR
NR
NR
mo
mo
NR
NR
d
w
d
d
d
d
d
NR
NR
d
mo
yr
NR
NR
NR
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
JV
JV
AD
JV
F
F
M
M
F
M
B
B
NR
B
B
M
M
B
F
F
M
M
M
M
C
C
C
C
C
C
C
C
C
C
C
C
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
BIO
ENZ
CHM
ENZ
CHM
ENZ
CHM
CHM
ENZ
HRM
HRM
ENZ
HRM
ENZ
ENZ
ENZ
CHM
CHM
HRM
CHM
ASAT
GBCM
GENZ
RBCE
GENZ
TRYP
CHOL
ACHE
DOPA
DOPA
ACHE
TRII
GENZ
GLPX
ASAT
HMGL
PORP
DOPA
PORP
SR
UR
LI
BL
AR
BR
SR
BR
BR
BR
BR
SR
LI
PL
BL
BL
UR
BR
UR
1.80


















2.88
0.880
1.20
50.0
0.200
3.0
3.78
5.0
5.0
5.0
5.0
6.36
6.60
100
25.0
25.0
20.0
2.56
50.0
N
N
Y
N
Y
N
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
10.1
10.1
0.2000
0.523
0.056
0.022
0.2350
0.050
0.2152
0.0313
0.25
0.290
0.0300
5.40
14.8
11.0
0.030
0.080
0.0300
N
N
N
Y
N
N
N
N
N
N
N
N
N
Y
N
N
Y
N
Y
0.4597
0.4597
0.02326
0.01568
0.006426
0.002981
0.02689
0.005855
0.01943
0.003984
0.02198
0.03249
0.004217
0.5100
0.6294
0.8568
0.0350
0.01020
0.0240
1.04


















1.66
0.500
1.20
1.50
2.06
2.51
3.78
5.00
5.00
5.00
5.00
6.36
6.60
9.44
14.4
14.4
24.6
32.0
42.1
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
5
10
8
8
5
8
10
8
10
5
5
10
8
5
5
5
5
5
10
5
10
10
10
5
10
5
10
5
5
5
5
10
5
5
5
5
10
10
10
10
10
10
10
10
4
10
10
10
10
10
10
10
10
10
10
10
10
10
6
6
10
10
10
10
10
10
10
10
7
10
10
7
7
7



















10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
3
10
10
10
10
10
10
10
10
10
10
3
10
10
10
10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
80
79
69
68
73
77
69
77
68
77
74
69
69
71
70
69
66
66
66
Behavior
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
15007
15471
14583
14508
15358
14508
15709
15007
15288
14603
14580
14577
4
15216
15216
1244
15530
15530
Plunder etal, 1999
Bencko 1972
Neiger and Osweiler 1989
Franke and Moxon 1937
Fowler and Woods 1979
Franke and Moxon 1937
Morrison and Chavez, 1983
Plunder etal, 1999
Benese and Bencko, 1981
Coulsonetal, 1935
Mahaffey etal., 1977
Itohetal., 1990
Brown etal., 1976
Nagaraja andDesiraju, 1994
Nagaraja andDesiraju, 1994
Cabe, etal., 1979
Garcia- Vargas et al, 1995
Garcia- Vargas et al, 1995
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenite
Sodium arsenite
Arsenic trioxide
Sodium arsenate
Arsenic trioxide
sodium arsenate heptahydrate
Sodium arsenate
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenate
100
100
57.69
100
100
100
100
100
100
100
100
83.53
100
100
100
100
100
100
Guinea pig (Cavia porcellus}
Mouse (Mus musculus }
Dog (Canis familiaris}
Rat (Rattus norvegicus}
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Pig (Sus scrofa }
Mouse (Mus musculus }
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus }
Mouse (Mus musculus }
3
1
1
1
1
2
i
2
1
2
i
i
i
i
2
i
i
2
4
3
4
2
4
2
2
4
4
2
2
3
4
2
2
2
2
2
0/10/30/60
0/0.88/6.0
0.0/0.88/1.80/2.88
0/1.88
0/20/40/85
0/3.22
0/100
0/10/30/60
0/4.945/49.45/249.4
0/0.21
0/50
0/3/10
0/4.7/9.4/10.9
0/5
0/5
0/50
0/20
0/50
mg/kg diet
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/L
mg/kg bw/d
mg/kg diet
mg/kg diet
mg/L
mg/org/d
mg/kg diet
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/L
mg/L
mg/L
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
na
na
na
na
na
na
na
na
na
na
na
na
na
na
na
na
na
na
ADL
NR
DLY
DLY
DLY
DLY
ADL
ADL
NR
NR
ADL
DLY
ADL
DLY
DLY
ADL
ADL
ADL
U
U
U
U
U
U
U
U
U
M
UX
U
U
U
U
U
U
U
FD
DR
FD
FD
DR
FD
FD
FD
DR
FD
FD
OR
DR
GV
FD
DR
DR
DR
3
64
1
100
6
100
6
3
32
52
10
14
6
21
90
18
6
6
w
d
w
d
w
d
w
w
d
w
w
d
w
d
d
w
w
w
NR
NR
8
28
NR
28
21
NR
NR
33-35
NR
4
NR
2
90
50
NR
NR
NR
NR
mo
d
NR
d
d
NR
NR
d
NR
w
NR
d
d
d
NR
NR
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
F
M
F
M
M
M
B
F
M
B
M
M
M
B
B
M
M
M
c
c
M
C
c
c
c
c
c
c
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
BEH
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
FOB
BEH
FOB
FOB
BEH
FOB
FOB
FOB
FCNS
WCON
FCNS
FCNS
WCON
FCNS
FCNS
FCNS
WCON
FCNS
FCNS
ACTV
WCON
FCNS
ACTP
WCON
WCON
WCON
WO
WO
WO
WO
WO
WO
WO
WO
WO
WO
WO
WO
WO
wo
wo
wo
wo
wo
10.0
0.880
1.80
1.88
20.0
3.22
100
30.0
49.5









30.0
6.00
2.88

40.0


60.0
249
0.21
50.0
3.0
4.70
5.0
5.0
50.0
20.0
50.0
Y
Y
N
Y
Y
Y
Y
Y
Y
Y
N
Y
Y
Y
Y
Y
Y
Y
0.315
0.03329
10.1
0.2874
0.0267
0.2635
14.2
0.0300
0.0325
0.4450
0.523
0.022
0.444
0.050
0.250
0.200
0.0300
0.0300
N
Y
N
Y
N
Y
Y
N
Y
Y
Y
N
Y
N
N
N
Y
Y
0.02658
0.005790
0.4597
0.01296
0.003801
0.01109
0.5100
0.003847
0.004225
0.01208
0.01568
0.002981
0.01785
0.005855
0.02198
0.02326
0.0350
0.0240
0.844
0.880
1.04
1.88
2.84
3.22
3.59
3.85
6.43









2.53
6.00
1.66

5.69


7.69
32.4
0.472
1.50
2.51
4.70
5.0
5.0
5.81
24.6
42.1
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
5
10
10
5
10
10
10
5
10
10
8
5
8
10
5
5
5
5
5
5
5
5
5
5
5
5
10
10
10
5
10
5
5
5
5
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
6
7
10
10
6
10
7
6
7
7
6
10
10
10
6
6
7
7
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
10
8
10
4
10
4
4
10
8
4
4
4
4
4
4
4
4
4
10
10
10
1
10
1
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
3
10
6
10
10
10
10
10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
79
73
83
68
74
68
74
79
73
79
71
80
68
80
73
68
69
69
Physiology
38
39
40
41
42
43
44
45
46
47
48
15471
15061
15174
15174
15174
15709
4
14546
15249
15322
25916
Bencko 1972
Kanisawa and Schroeder, 1 969
Carmignani etal, 1985
Carmignani etal, 1985
Carmignani etal, 1985
Morrison and Chavez, 1983
Brown etal., 1976
Nagaraja and Desiraju 1993
Carmignani et al 1983
Biswas et al, 1998
Biswas, et al, 2000
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenite
Sodium arsenite
sodium arsenate heptahydrate
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenite
100
100
45.71
57.69
57.69
100
100
100
100
57.69
57.69
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rabbit (Oryctolagus cuniculus}
Rat (Rattus norvegicus}
Pig (Sus scrofa }
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Goat (Capra hircus}
Goat (Ovis aries}
1
1
2
3
1
1
1
1
1
1
1
3
2
2
2
2
2
4
2
2
2
2
0/0.88/6.0
0/5
0/50
0/50
0/50
0/100
0/4.7/9.4/10.9
0/5
0/50
0/25.0
0/25
mg/kg bw/d
mg/L
mg/L
mg/L
mg/L
mg/kg diet
mg/kg bw/d
mg/kg bw/d
mg/L
mg/kg bw/d
mg/kg bw/d
N
N
Y
Y
Y
N
N
N
N
N
N
na
na
na
na
na
na
na
na
na
na
na
NR
DLY
NR
NR
NR
ADL
ADL
DLY
DLY
ADL
DLY
U
U
U
U
U
U
U
U
U
U
U
DR
DR
DR
DR
DR
FD
DR
GV
DR
DR
OR
32
18
18
10
18
6
6
18
320
6
9
d
mo
mo
mo
mo
w
w
d
d
w
w
NR
21
NR
NR
NR
21
NR
2
NR
1
12
NR
d
NR
NR
NR
d
NR
d
NR
yr
mo
JV
JV
NR
NR
NR
JV
JV
JV
JV
JV
AD
M
B
M
F
M
B
M
B
M
F
F
c
c
c
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
PHY
GPHY
BLPR
GPHY
BLPR
BLPR
EXCR
RPRT
GPHY
GPHY
GPHY
RPRT
LI
wo
wo
wo
wo
wo
KI
HA
HA
BL
WO
0.880










6.00
5.0
50
50
50
100
4.70
5.0
50.0
25.0
25.0
Y
N
N
N
N
Y
Y
Y
N
Y
Y
0.03329
0.248
0.50
4.10
0.50
14.2
0.444
0.0313
0.2670
11.0
21.3
Y
N
N
N
N
Y
Y
N
N
N
N
0.005790
0.02823
0.05305
0.3525
0.05305
0.5100
0.01785
0.003984
0.03016
0.8568
0.8490
0.880










6.00
0.569
2.55
2.61
3.22
3.59
4.70
5.0
5.65
14.4
14.4
10
10
10
10
10
10
10
10
10
10
10
5
5
5
5
5
10
5
8
5
5
8
5
5
5
5
5
5
5
10
5
5
10
10
10
10
10
10
10
10
10
10
10
10
7
5
5
5
5
7
10
10
5
10
10
4
4
4
4
4
4
4
4
4
4
4
8
4
4
4
4
4
4
4
4
4
4
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
6
10
10
10
3
4
4
4
4
4
4
4
4
4
4
4
73
67
67
67
67
74
68
80
67
72
73
Pathology
49
50
51
52
53
54
15160
14603
15061
15057
15471
12934
Hughes and Thompson, 1 996
Coulsonetal, 1935
Kanisawa and Schroeder, 1 969
Nemecetal, 1998
Bencko 1972
Obermeyer et al, 1971
Sodium arsenate heptahydrate
Arsenic trioxide
Sodium arsenate
Arsenic acid
Sodium arsenite
Sodium arsenite
100
100
100
100
100
100
Mouse (Mus musculus }
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rabbit (Oryctolagus cuniculus}
Mouse (Mus musculus }
Rat (Rattus norvegicus}
1
2
1
3
1
1
3
2
2
4
3
2
0/0.014/1.4
0/0.21
0/5
0/0.19/0.75/3.0
0/0.88/6.0
0/10
mg/L
mg/org/d
mg/L
mg/kg bw/d
mg/kg bw/d
mg/kg diet
N
N
N
N
N
N
na
na
na
na
na
na
ADL
NR
DLY
DLY
NR
ADL
U
M
U
M
U
U
DR
FD
DR
GV
DR
FD
28
52
42
7
64
4
d
w
mo
d
d
w
96
33-35
21
NR
NR
NR
d
d
d
NR
NR
NR
SM
JV
JV
GE
JV
JV
F
B
B
F
M
M
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
PTH
PTH
PTH
PTH
PTH
PTH
ORW
HIS
HIS
GRS
ORW
ORW
ORWT
GHIS
GHIS
BDWT
ORWT
SMLX
LI
LI
KI
WO
SP
LI
0.0140
0.210
5.0
0.75
0.880
10.0
1.40


3.0
6.00

Y
Y
N
Y
Y
Y
0.0799
0.4700
0.248
4.36
0.03329
0.202
Y
Y
N
N
Y
N
0.0049
0.01168
0.02823
0.2303
0.005790
0.01843
0.000859
0.447
0.569
0.750
0.880
0.913
0.0859


3.0
6.00

10
10
10
10
10
10
5
10
5
8
5
10
5
10
5
10
5
5
10
10
10
10
10
10
7
7
5
10
7
6
4
4
4
4
4
4
6
4
4
8
8
4
10
1
10
10
10
10
6
10
10
10
10
10
4
4
4
4
4
4
67
69
67
84
73
73
Eco-SSLfor Arsenic
March 2005

-------
                                                         Appendix 6.1  Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                                                                   Arsenic
                                                                                                 Page 2 of 4
Ref
Result #
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
Z;
1
14589
14583
14569
15358
2
2
15057
15530
15530
113
14543
14543
7
14580
15011
4
15216
14546
14546
15216
15249

c
1
Tice etal 1997
Neiger and Osweiler 1989
Fowler etal., 1977
Fowler and Woods 1 979
Byron etal, 1967
Byron etal, 1967
Nemecetal, 1998
Garcia- Vargas et al, 1995
Garcia- Vargas et al, 1995
Seidenberg et al 1986
Healyetal., 1998
Healyetal., 1998
Schroeder et al, 1968
Mahaffeyetal., 1977
Ghosh etal 1999
Brown etal., 1976
Nagaraja andDesiraju, 1994
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Nagaraja andDesiraju, 1994
Carmignani et al 1983
Exposure
S
1
1
g
u
6
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenate heptahydrate
Arsenic acid
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenate heptahydrate
Sodium arsenite
Sodium arsenate
Sodium arsenite
sodium arsenate heptahydrate
Sodium arsenate
Arsenic
Sodium arsenate
Sodium arsenate
Sodium arsenate
SS
^
57.69
57.69
100
100
100
100
100
100
100
45.71
100
100
100
100
57.69
100
100
100
100
100
100
.1
1
«
H
Mouse (Mus musculus )
Dog (Canisfamiliaris~)
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus~)
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus~)
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Phase #
1
1
1
1
1
2
1
1
2
1
2
i
i
i
i
i
i
2
1
2
i
# of Cone/ Doses
4
4
4
4
6
6
4
2
2
2
3
3
2
2
3
4
2
2
2
2
2
1
o
Q
1
o
O
0/2.5/5.0/10.0
0.0/0.88/1.80/2.88
0/20/40/85
0/20/40/85
0/15.63/31.25/62.5/125/250
0/31.25/62.5/125/250/400
0/7.5/24/48
0/20
0/50
0/95
0/6.5/750
0/8.5/827
0/5
0/50
0/0.2/0.4
0/4.7/9.4/10.9
0/5
0/5
0/5
0/5
0/50
Cone/Dose Units
mg/kg bw/d
mg/kg bw/d
mg/L
mg/L
mg/kg diet
mg/kg diet
mg/kg bw/d
mg/L
mg/L
mg/kg bw/d
ug/kg bw/d
ug/kg bw/d
mg/L
mg/kg diet
mg/org/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/L
Wet Weight Reported?
N
N
N
N
N
N
N
Y
Y
N
N
N
N
N
N
N
N
N
N
N
N
Percent Moisture
na
na
na
na
na
na
na
na


na
na


na
na
na
na
na
na

Application Frequency
DLY
DLY
ADL
DLY
NR
NR
DLY
ADL
ADL
DLY
ADL
ADL
ADL
ADL
DLY
ADL
DLY
DLY
DLY
DLY
DLY
Method of Analyses
U
U
U
U
U
U
M
U
U
U
U
U
U
ux
U
U
U
U
U
U
U
Route of Exposure
GV
FD
DR
DR
FD
FD
GV
DR
DR
GV
DR
DR
DR
FD
GV
DR
GV
FD
GV
FD
DR
Exposure Duration
4
8
6
6
2
2
6
6
6
5
91
32
1575
10
28
6
20
90
18
90
320
Duration Units
d
w
w
w
yr
yr
d
w
w
d
d
d
d
w
d
w
d
d
d
d
d
&
•3
12
8
NR
NR
NR
NR
NR
NR
NR
NR
76
76
21-23
NR
35
NR
2
90
2
90
NR
Age Units
w
mo
NR
NR
NR
NR
NR
NR
NR
NR
d
d
d
NR
d
NR
d
d
d
d
NR
Lifestage
JV
JV
JV
JV
JV
JV
GE
JV
JV
GE
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
X
<2
M
F
M
M
B
B
F
M
M
F
M
M
M
M
F
M
B
NR
B
B
M

Control Type
M
M
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C

o
H
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Effects
General Effect Group
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
PTH
Effect Type
HIS
ORW
HIS
HIS
HIS
HIS
GRS
ORW
ORW
GRS
ORW
ORW
ORW
GRS
ORW
ORW
ORW
ORW
ORW
ORW
HIS
3
S
^
USTR
SMLX
USTR
USTR
GHIS
GHIS
BDWT
SMLX
SMLX
BDWT
ORWT
ORWT
SMLX
BDWT
SMLX
SMLX
ORWT
ORWT
ORWT
ORWT
GHIS
Response Site
BL
LI
LI
LI
LI
LI
WO
LI
LI
WO
LI
KI
HE
WO
AR
KI
BR
BR
BR
BR
KI
J
H
1
^1
i
s
2.5
2.88
20.0
20.0
62.5
125
24.0
20.0
50.0
95.0











Conversion to mg/kg bw/day
Study LOAEL
5.0

40.0
40.0
125
250
48.0



6.50
8.5
5.0
50.0
0.200
4.70
5.0
5.0
5.0
5.0
50.0
Body Weight Reported?
N
N
Y
Y
Y
Y
Y
Y
Y
Y
N
N
Y
N
Y
N
Y
Y
Y
Y
N
Body Weight in kg
0.0316
10.1
0.325
0.0267
0.4728
0.4652
0.0527
0.0300
0.0300
0.043
0.0316
0.0316
0.4790
0.523
0.056
0.444
0.050
0.2152
0.0313
0.250
0.2670
Ingestion Rate Reported?
N
N
N
N
N
N
N
Y
Y
N
Y
Y
N
Y
N
Y
N
N
N
N
N
Ingestion Rate in kg or L/day
0.004015
0.4597
0.03600
0.003801
0.03711
0.03662
0.006113
0.0350
0.0240
0.00517
na
na
0.05104
0.01568
0.006426
0.01785
0.005855
0.01943
0.003984
0.02198
0.03016
Result
NOAELDose (mg/kg/day)
1.44
1.66
2.22
2.84
4.91
9.84
24.0
24.6
42.1
43.4











LOAEL Dose (mg/kg/day)
2.88

4.43
5.69
9.81
19.7
48.0



0.00650
0.0085
0.533
1.50
2.06
4.70
5.0
5.0
5.0
5.0
5.65
Data Evaluation Score
Data Source
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
Dose Route
8
10
5
5
10
10
8
5
5
8
5
5
5
10
8
5
8
10
8
10
5
Test Concentrations
10
5
5
5
5
5
10
5
5
10
5
5
5
10
10
5
10
5
10
5
5
Chemical form
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
4
10
10
10
Dose Quantification
10
10
6
6
6
6
10
7
7
10
6
6
6
6
6
10
10
10
10
6
5
Endpoint
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Dose Range
10
4
10
10
10
10
10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
Statistical Power
10
1
10
10
10
10
10
10
10
8
10
10
10
10
10
10
10
10
10
10
10
Exposure Duration
10
10
10
10
10
10
10
10
10
10
10
10
10
3
10
6
10
10
10
10
10
Test Conditions
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
o
H
86
68
74
74
79
79
86
69
69
78
68
68
68
71
76
68
80
71
80
73
67
Reproduction
76
77
78
79
80
81
82
83
14556
15057
15125
15057
14543
66
15167
113
Savabieasfahani et al, 1998
Nemecetal, 1998
Moms etal, 1938
Nemecetal, 1998
Healyetal., 1998
Schroeder and Mitchener, 1971
Skalnaya et al, 1996
Seidenberg et al 1986
Sodium arsenite
Arsenic acid
Arsenic trioxide
Arsenic acid
Sodium arsenate heptahydrate
Arsenite
Sodium arsenite
Sodium arsenate
57.69
100
100
100
100
75.74
56.6
45.71
Cotton rat (Sigmodon hispidus )
Rabbit (Oryctolagus cuniculus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
i
3
1
1
2
i
i
i
3
4
3
4
3
2
2
2
0/0.088/0.15
0/0.19/0.75/3.0
0/450/4100
0/7.5/24/48
0/6.5/750
0/5
0/10
0/95
mg/org/d
mg/kg bw/d
ug/org/d
mg/kg bw/d
ug/kg bw/d
mg/L
mg/kg bw/d
mg/kg bw/d
N
N
N
N
N
N
N
N

na

na
na



ADL
DLY
ADL
DLY
ADL
ADL
DLY
DLY
U
M
U
M
U
U
U
U
DR
GV
FD
GV
DR
DR
OR
GV
6
12
340
9
91
6
30
5
w
d
d
d
d
mo
d
d
NR
NR
26-27
NR
76
21
NR
NR
NR
NR
d
NR
d
d
NR
NR
AD
GE
JV
GE
JV
JV
GE
GE
M
F
M
F
M
F
F
F
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
REP
TEWT
RSEM
PRWT
PROG
TEWT
PROG
PRWT
PROG
TE
WO
WO
WO
TE
WO
WO
WO
0.150
0.750
4100
24.0





3.0

48.0
6.50
5.0
10.0
95.0
N
Y
Y
Y
N
N
N
Y
0.144
4.355
0.549
0.0549
0.0316
0.0225
0.0288
0.043
Y
N
N
N
Y
N
N
N
0.01530
0.2303
0.01905
0.006322
na
0.003255
0.003715
0.00517
0.601
0.750
7.47
24.0





3.0

48.0
0.00650
0.548
5.66
43.4
10
10
10
10
10
10
10
10
5
8
10
8
5
5
8
8
5
10
5
10
5
5
5
10
10
10
10
10
10
4
10
10
6
10
7
10
6
5
10
10
10
10
10
10
10
10
10
10
4
10
4
8
4
4
4
4
10
10
1
10
10
10
10
10
6
10
10
10
10
10
10
10
4
4
4
4
4
4
4
4
70
92
71
92
74
67
81
86
Growth
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
15160
14603
3701
7
12934
14583
15262
15262
14508
2
15264
15358
14508
15011
14569
15007
15471
15288
15125
15007
4
2
2
20979
3084
15007
15216
Hughes and Thompson, 1 996
Coulsonet al, 1935
Kanisawa and Schroeder, 1 969
Schroeder et al, 1968
Obermeyer et al, 1971
Neiger and Osweiler 1989
Palmer etal 1983
Palmer etal 1983
Franke and Moxon 1937
Byron etal, 1967
Schmolke etal 1992
Fowler and Woods 1 979
Franke and Moxon 1937
Ghosh etal 1999
Fowler etal., 1977
Hunder et al, 1999
Bencko 1972
Benese and Bencko, 1981
Moms etal, 1938
Hunder et al, 1999
Brown etal., 1976
Byron etal, 1967
Byron etal, 1967
Kanisawa and Schroeder, 1 967
Schroeder and Balassa, 1967
Hunder et al, 1999
Nagaraja andDesiraju, 1994
Sodium arsenate heptahydrate
Arsenic trioxide
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenite
Sodium arsenate
Sodium arsenite
Sodium arsenite
Sodium arsenite
Arsenic trioxide
Sodium arsenite
sodium arsenate heptahydrate
Sodium arsenate heptahydrate
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
100
100
100
100
100
57.69
100
100
100
100
100
100
100
57.69
100
100
100
100
100
100
100
100
100
100
100
100
100
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Dog (Canisfamiliaris')
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Dog (Canisfamiliaris}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Mouse (Mus musculus )
Guinea pig (Cavia porcellus}
Rat (Rattus norvegicus}
i
2
1
1
1
1
1
2
i
3
1
1
2
i
i
i
i
i
i
2
i
2
1
1
1
3
1
3
2
2
2
2
4
2
2
2
5
3
4
2
3
4
4
3
4
3
4
4
6
6
2
2
4
2
0/0.014/1.4
0/0.21
0/5
0/5
0/10
0.0/0.88/1.80/2.88
0/16
0/20
0/1.88
0/5/25/50/125
0/15/30
0/20/40/85
0/3.22
0/0.2/0.4
0/20/40/85
0/10/30/60
0/0.88/6.0
0/4.945/49.45/249.4
0/450/4100
0/10/30/60
0/4.7/9.4/10.9
0/31.25/62.5/125/250/400
0/15.63/31.25/62.5/125/250
0/5
0/5
0/10/30/60
0/5
mg/L
mg/org/d
mg/L
mg/L
mg/kg diet
mg/kg bw/d
ug/g diet
ug/g diet
mg/kg bw/d
mg/kg diet
mg/kg diet
mg/L
mg/kg bw/d
mg/org/d
mg/L
mg/kg diet
mg/kg bw/d
mg/L
ug/org/d
mg/kg diet
mg/kg bw/d
mg/kg diet
mg/kg diet
mg/L
mg/L
mg/kg diet
mg/kg bw/d
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N





na
na
na

na



na
na

na



na
na
na



na
ADL
NR
ADL
ADL
ADL
DLY
ADL
ADL
DLY
NR
DLY
DLY
DLY
DLY
ADL
ADL
NR
NR
ADL
ADL
ADL
NR
NR
NR
ADL
ADL
DLY
U
M
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
DR
FD
DR
DR
FD
FD
FD
FD
FD
FD
FD
DR
FD
GV
DR
FD
DR
DR
FD
FD
DR
FD
FD
DR
DR
FD
GV
28
52
519
69
4
8
4
8
100
2
15
6
100
28
6
3
64
32
340
3
6
12
12
338
339
3
20
d
w
d
d
w
w
w
w
d
yr
w
w
d
d
w
w
d
d
d
w
w
w
w
d
d
w
d
96
33-35
21
21-23
NR
8
NR
NR
28
6
7
NR
28
35
NR
NR
NR
NR
26-27
NR
NR
NR
NR
20-22
21
NR
2
d
d
d
d
NR
mo
NR
NR
d
mo
w
NR
d
d
NR
NR
NR
NR
d
NR
NR
NR
NR
d
d
NR
d
SM
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
F
B
B
B
NR
F
M
M
M
B
F
M
M
F
M
F
M
M
M
F
M
B
M
M
B
F
B
c
c
c
c
c
M
V
V
c
c
M
C
C
c
c
c
c
c
c
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
WO
WO
WO
WO
WO
WO
WO
WO
WO
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
1.40
0.210
5.0
5.0
10.0
1.80
16.0
20.0
1.88
50.0
30.0
20.0
3.22
0.400
40.0
60.0
6.000
49.5
4100
60.0
9.40
125
125









2.88



125

40.0


85.0


249


10.7
250
250
5.0
5.0
10.0
5.0
Y
Y
Y
Y
Y
N
Y
Y
Y
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
0.0799
0.4700
0.479
0.4790
0.202
10.1
0.2652
0.3624
0.2874
10.8
0.3250
0.0267
0.2635
0.061
0.325
0.193
0.03329
0.0325
0.549
0.030
0.423
0.4652
0.358
0.0536
0.052
0.305
0.050
Y
Y
N
N
N
N
N
N
Y
N
N
N
Y
N
N
N
Y
Y
N
N
Y
N
N
N
N
N
N
0.0049
0.01168
0.05104
0.0280
0.01843
0.4597
0.02308
0.02983
0.01296
0.4858
0.02727
0.003801
0.01109
0.006894
0.03600
0.01777
0.005790
0.004225
0.01905
0.003847
0.01785
0.03662
0.02952
0.007110
0.069189
0.02589
0.005855
0.0859
0.447
0.533
0.571
0.913
1.04
1.39
1.65
1.88
2.25
2.52
2.84
3 22
3.78
4.43
5.52
6.00
6.43
7.47
7.69
9.40
9.84
10.3









1.66



5.62

5.69


9.42


32.4


10.7
19.7
20.6
0.663
0.665
0.844
5.0
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
5
10
5
5
10
10
10
10
10
10
10
5
10
8
5
10
5
5
10
10
5
10
10
5
5
10
8
5
10
5
5
5
5
5
5
5
5
5
5
5
10
5
5
5
5
5
5
5
5
5
5
5
5
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
7
7
6
6
6
10
6
6
10
5
6
6
10
6
6
6
7
7
7
6
10
6
6
6
6
6
10
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
8
4
4
4
4
4
10
4
4
4
10
4
10
4
4
10
4
4
8
4
4
10
10
10
4
4
4
4
10
1
10
10
10
10
1
1
1
10
1
10
1
3
10
1
10
10
1
1
10
10
10
10
10
10
10
6
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
6
10
10
10
10
10
10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
69
74
72
72
77
87
68
68
72
82
68
78
72
73
78
68
73
77
69
68
78
83
83
72
72
77
84
Eco-SSLfor Arsenic
March 2005

-------
                                                         Appendix 6.1  Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                                                                   Arsenic
                                                                                                 Page 3 of 4
Ref
Result #
111
112
113
114
115
116
117
118
Z;
1
14546
14546
15427
15216
11361
15709
15322
25916

c
1
Nagaraja and Desiraju 1993
Nagaraja and Desiraju 1993
Kiyonoetal, 1974
Nagaraja and Desiraju, 1994
Glattreet. al., 1995
Morrison and Chavez, 1983
Biswas etal, 1998
Biswas, et al, 2000
Exposure
S
1
1
g
u
6
Arsenic
Sodium arsenate
Arsenic trioxide
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenite
Sodium arsenite
Sodium arsenite
SS
^
100
100
100
100
100
100
57.69
57.69
.1
1
«
H
Rat (Rattus norvegicus)
Rat (Rattus norvegicus~)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Pig (Sus scrofa )
Goat (Copra hircus)
Goat (Ovis ones)
Phase #
2
1
1
2
i
i
i
i
# of Cone/ Doses
2
2
4
2
2
2
2
2
1
o
Q
1
o
O
0/5
0/5
0/5.0/7.5/10.0
0/5
0/6.36
0/100
0/25.0
0/25
Cone/Dose Units
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/kg diet
mg/kg bw/d
mg/kg bw/d
Wet Weight Reported?
N
N
N
N
N
N
N
N
Percent Moisture
na
na

na
na
na
na

Application Frequency
DLY
DLY
DLY
DLY
ADL
ADL
ADL
DLY
Method of Analyses
U
U
U
U
U
U
U
U
Route of Exposure
FD
GV
GV
FD
DR
FD
DR
OR
Exposure Duration
90
18
10
90
4
2
9
9
Duration Units
d
d
d
d
w
w
w
w
&
•3
90
2
1
90
NR
21
1
12
Age Units
d
d
d
d
NR
d
yr
mo
Lifestage
JV
JV
JV
JV
JV
JV
JV
AD
x
<2
NR
B
M
B
M
B
F
F

Control Type
C
C
C
c
c
c
c
c

o
H
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Effects
General Effect Group
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
Effect Type
GRO
GRO
GRO
GRO
GRO
GRO
GRO
GRO
3
S
^
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
BDWT
Response Site
WO
WO
wo
wo
wo
wo
wo
wo
J
H
|
^1
i
s








Conversion to mg/kg bw/day
Study LOAEL
5.0
5.0
5.0
5.0
6.36
100
25.0
25.0
Body Weight Reported?
Y
Y
Y
Y
Y
Y
Y
Y
Body Weight in kg
0.2152
0.0313
0.025
0.250
0.290
5.40
19.6
21.3
Ingestion Rate Reported?
N
N
N
N
N
Y
N
N
Ingestion Rate in kg or L/day
0.01943
0.003984
0.003312
0.02198
0.03249
0.5100
1.441
0.8490
Result
NOAELDose (mg/kg/day)








LOAEL Dose (mg/kg/day)
5.0
5.0
5.0
5.0
6.36
9.44
14.4
14.4
Data Evaluation Score
Data Source
10
10
10
10
10
10
10
10
Dose Route
10
8
8
10
5
10
5
8
Test Concentrations
5
10
10
5
5
5
5
10
Chemical form
4
10
10
10
10
10
10
10
Dose Quantification
10
10
10
6
10
7
10
10
Endpoint
8
8
8
8
8
8
8
8
Dose Range
4
4
4
4
4
4
4
4
Statistical Power
10
10
10
10
10
10
10
10
Exposure Duration
10
10
10
10
10
10
10
3
Test Conditions
4
4
4
4
4
4
4
4
3
o
H
75
84
84
77
76
78
76
77
Survival
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
7
15057
15262
15262
14508
2
2
15057
14508
15427
1244
14569
2
2
15057
14590
3084
15322
25916
113
Schroeder et al, 1968
Nemecetal, 1998
Palmer etal 1983
Palmer etal 1983
Franke and Moxon 1937
Byron etal, 1967
Byron etal, 1967
Nemecetal, 1998
Franke and Moxon 1937
Kiyonoetal, 1974
Cabe, etal., 1979
Fowler etal., 1977
Byron etal, 1967
Byron etal, 1967
Nemecetal, 1998
Trrpathi etal 1997
Schroeder and Balassa, 1967
Biswas et al, 1998
Biswas, et al, 2000
Seidenberg et al 1986
Sodium arsenite
Arsenic acid
Sodium arsenite
Sodium arsenite
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenite
Arsenic acid
Sodium arsenate
Arsenic trioxide
Sodium arsenate
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenite
Arsenic acid
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
100
57.69
57.69
45.71
Rat (Rattus norvegicus~)
Rabbit (Oryctolagus cuniculus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Dog (Canisfamiliaris~)
Dog (Canisfamiliaris)
Rabbit (Oryctolagus cwiiculus}
Rat (Rattus norvegicus~)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus~)
Mouse (Mus musculus )
Rat (Rattus norvegicus)
Mouse (Mus musculus )
Goat (Copra hircus)
Goat (Ovis aries)
Mouse (Mus musculus )
i
3
i
2
1
4
3
2
2
1
1
1
2
1
1
1
1
1
1
1
2
4
2
2
2
5
5
6
2
4
2
4
6
6
4
2
2
2
2
2
0/5
0/0.19/0.75/3.0
0/16
0/20
0/1.88
0/5/25/50/125
0/5/25/50/125
0/0.75/2.25/4.5/6.75/9.0
0/3.22
0/5.0/7.5/10.0
0/50
0/20/40/85
0/31.25/62.5/125/250/400
0/15.63/31.25/62.5/125/250
0/7.5/24/48
0/2.56
0/5
0/25.0
0/25
0/95
mg/L
mg/kg bw/d
ug/g diet
ug/g diet
mg/kg bw/d
mg/kg diet
mg/kg diet
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
mg/L
mg/L
mg/kg diet
mg/kg diet
mg/kg bw/d
mg/org/d
mg/L
mg/kg bw/d
mg/kg bw/d
mg/kg bw/d
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N

na
na
na

na
na
na



na
na
na
na


na


ADL
DLY
ADL
ADL
DLY
NR
NR
DLY
DLY
DLY
ADL
ADL
NR
NR
DLY
ADL
ADL
ADL
DLY
DLY
U
M
U
U
U
U
U
M
U
U
U
U
U
U
M
U
U
U
U
U
DR
GV
FD
FD
FD
FD
FD
GV
FD
GV
DR
DR
FD
FD
GV
DR
DR
DR
OR
GV
1575
12
4
8
100
13.5
2
12
100
10
18
6
78
2
9
16
519
78
12
5
d
d
w
w
d
mo
yr
d
d
d
w
w
w
yr
d
w
d
d
w
d
21-23
NR
NR
NR
28
6
6
NR
28
1
50
NR
NR
NR
NR
NR
21
1
12
NR
d
NR
NR
NR
d
mo
mo
NR
d
d
d
NR
NR
NR
NR
NR
d
yr
mo
NR
JV
GE
JV
JV
JV
JV
JV
GE
JV
JV
JV
JV
JV
JV
GE
JV
JV
JV
AD
GE
B
F
M
M
M
B
B
F
M
M
M
M
B
B
F
M
M
F
F
F
c
c
V
V
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
MOR
SURV
MORT
MORT
SURV
MORT
MORT
MORT
MORT
MORT
MORT
MORT
MORT
SURV
SURV
MORT
MORT
SURV
MORT
MORT
MORT
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
wo
5.0
0.750
16.0
20.0
1.88
50.0
50.0
2.25
3.22
5.0
50.0
85.0
125
125
24.0
2.56





3.0



125
125
4.50

7.5


250
250
48.0

5.0
25.0
25.0
95.0
Y
Y
Y
Y
Y
N
N
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
0.4790
4.36
0.2652
0.3624
0.2874
10.8
10.8
4.10
0.2635
0.025
0.200
0.260
0.5206
0.4279
0.0527
0.080
0.045
19.6
20.1
0.043
N
N
N
N
Y
N
N
N
Y
N
N
N
N
N
N
Y
N
N
N
N
0.05104
0.2303
0.02308
0.02983
0.01296
0.4858
0.4858
0.2191
0.01109
0.003312
0.02326
0.02945
0.04017
0.03419
0.006113
0.01020
0.006075
1.441
0.8094
0.00517
0.533
0.750
1.39
1.65
1.88
2.25
2.25
2.25
3.22
5.00
5.81
9.63
9.65
9.99
24.0
32.0





3.00



5.62
5.62
4.50

7.5


19.3
20.0
48.0

0.675
14.4
14.4
43.4
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
5
8
10
10
10
10
10
8
10
8
5
5
10
10
8
5
5
5
8
8
5
10
5
5
5
5
5
10
5
10
5
5
5
5
10
5
5
5
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
6
10
6
6
10
5
5
10
10
10
6
6
6
6
10
7
6
10
10
10
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
4
8
4
4
4
10
10
10
4
10
4
4
10
10
10
4
4
4
4
4
10
10
10
1
10
10
10
10
1
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
3
10
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
73
89
78
69
82
83
83
91
73
91
73
73
84
84
91
74
73
77
78
85
Data Not Used to Derive TRV
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
15160
3701
757
757
14556
14556
14556
20979
20979
14543
14543
14543
14598
14598
15262
15262
14508
14414
14414
15264
14508
1244
1244
15125
15125
14590
15288
15198
Hughes and Thompson, 1 996
Kanisawa and Schroeder, 1 969
Mercado andBibby 1973
Mercado andBibby 1973
Savabieasfahani et al, 1998
Savabieasfahani et al, 1998
Savabieasfahani et al, 1998
Kanisawa and Schroeder, 1 967
Kanisawa and Schroeder, 1 967
Healyetal., 1998
Healyetal., 1998
Healyetal., 1998
Blakleyetal., 1980
Blakleyetal., 1980
Palmer etal 1983
Palmer etal 1983
Franke and Moxon 1937
Morgareidge, 1963
Morgareidge, 1963
Schmolke etal 1992
Franke and Moxon 1937
Cabe, etal., 1979
Cabe, etal., 1979
Moms etal, 1938
Moms etal, 1938
Tnpathietal 1997
Benese andBencko, 1981
Cobo etal 1995
Sodium arsenate heptahydrate
Sodium arsenite
Arsenic pentoxide
Arsenic pentoxide
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate heptahydrate
Sodium arsenate heptahydrate
Sodium arsenate heptahydrate
sodium arsenite
sodium arsenite
Sodium arsenite
Sodium arsenite
Sodium arsenate
Arsenic trioxide
Arsenic trioxide
Sodium arsenite
Sodium arsenate
Sodium arsenate
Sodium arsenate
Arsenic trioxide
Arsenic trioxide
Sodium arsenite
Sodium arsenite
MO,
100
100
100
100
57.69
57.69
57.69
100
100
100
100
100
57.69
57.69
100
100
100
100
100
100
100
100
100
100
100
100
100
37.9
Mouse (Mus musculus )
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Cotton rat (Sigmodon hispidus )
Cotton rat (Sigmodon hispidus )
Cotton rat (Sigmodon hispidus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus}
Rat (Rattus norvegicus)
Rat (Rattus norvegicus')
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Rat (Rattus norvegicus)
Mouse (Mus musculus )
Rat (Rattus norvegicus)
1
1
1
1
1
1
1
1
1
2
i
i
i
i
i
2
1
2
2
1
2
i
i
i
i
i
i
i
3
2
2
2
3
3
3
2
2
3
3
3
4
4
2
2
2
2
2
3
2
2
2
3
3
2
4
2
0/0.014/1.4
0/5
0/5
0/5
0/0.088/0.15
0/0.088/0.15
0/0.088/0.15
0/5
0/5
0/8.5/827
0/8.5/827
0/8.5/827
0/0.5/2.0/10.0
0/0.5/2.0/10.0
0/16
0/20
0/1.88
0/16
0/16
0/15/30
0/3.22
0/50
0/50
0/450/4100
0/450/4100
0/2.56
0/4.945/49.45/249.4
0/0.295
mg/L
mg/L
mg/L
mg/L
mg/org/d
mg/org/d
mg/org/d
mg/L
mg/L
ug/kg bw/d
ug/kg bw/d
ug/kg bw/d
mg/L
mg/L
ug/g diet
ug/g diet
mg/kg bw/d
mg/kg diet
mg/kg diet
mg/kg diet
mg/kg bw/d
mg/L
mg/L
ug/org/d
ug/org/d
mg/org/d
mg/L
mg/g bw
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N









na
na
na
na

na
na












ADL
ADL
ADL
ADL
ADL
ADL
ADL
NR
NR
ADL
ADL
ADL
NR
NR
ADL
ADL
DLY
DLY
DLY
DLY
DLY
ADL
ADL
ADL
ADL
ADL
NR
ADL
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
U
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
FD
FD
FD
FD
FD
FD
FD
DR
DR
FD
FD
DR
DR
DR
28
1175
50
50
6
6
6
24
518
32
32
32
3
3
4
8
100
4
4
15
100
18
18
340
340
16
32
8
d
d
d
d
w
w
w
mo
d
d
d
d
w
w
w
w
d
w
w
w
d
w
w
d
d
w
d
w
96
21
23
23
NR
NR
NR
20-22
20-22
76
76
76
6
6
NR
NR
28
NR
NR
7
28
50
50
26-27
26-27
NR
NR
NR
d
d
d
d
NR
NR
NR
d
d
d
d
d
w
w
NR
NR
d
NR
NR
w
d
d
d
d
d
NR
NR
NR
SM
JV
JV
JV
AD
AD
AD
JV
JV
JV
JV
JV
AD
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
JV
AD
F
B
M
M
M
M
M
B
B
M
M
M
M
M
M
M
M
B
B
F
M
M
M
M
M
M
M
M
c
c
c
c
c
c
c
c
c
c
c
c
c
c
V
V
c
c
c
M
c
c
c
c
c
c
c
c
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
BEH
MOR
PHY
GRO
BIO
GRO
PTH
MOR
PTH
GRO
BEH
GRO
BEH
GRO
PTH
PTH
BIO
BEH
GRO
BEH
BIO
GRO
PTH
BEH
PTH
BEH
BIO
BEH
FOB
MOR
PHY
GRO
CHM
GRO
ORW
MOR
HIS
GRO
FOB
GRO
FOB
GRO
ORW
ORW
CHM
FOB
GRO
FOB
CHM
GRO
ITX
FOB
ORW
FOB
CHM
FOB
WCON
TDTH
GPHY
BDWT
HMGL
BDWT
ORWT
MORT
GHIS
BDWT
WCON
BDWT
WCON
BDWT
ORWT
ORWT
HMGL
FCNS
BDWT
FCNS
HMGL
BDWT
INCO
FCNS
ORWT
WCON
LIPD
WCON
wo
wo
XX
wo
BL
wo
LI
wo
MT
wo
wo
wo
wo
wo
KI
KI
BL
WO
WO
wo
BL
WO
WO
WO
KI
WO
LI
WO
1.40
5.0
5.0
5.0
0.150
0.150
0.150
5.0
5.0
750
827
827
10.0
10.0
16.0
20.0
1.88
16.0
16.0
30.0
3.22
50.0
50.0
4100
4100
2.56
249
0.295




























Y
Y
N
N
Y
Y
Y
Y
Y
N
N
N
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
0.0799
0.479
0.2670
0.2670
0.144
0.144
0.144
0.0536
0.0536
0.0316
0.0316
0.0316
0.02857
0.02857
0.2652
0.3624
0.2874
0.1810
0.1810
0.3250
0.2635
0.200
0.200
0.549
0.549
0.080
0.0200
0.338
Y
N
N
N
Y
Y
Y
N
N
Y
Y
Y
Y
Y
N
N
Y
Y
Y
N
Y
N
N
N
N
Y
Y
N
0.0049
0.05104
0.03016
0.03016
0.01530
0.01530
0.01530
0.007110
0.007110
na
na
na
0.00437
0.00437
0.02308
0.02983
0.01296
0.02310
0.02310
0.02727
0.01109
0.02326
0.02326
0.01905
0.01905
0.01020
0.004225
0.03730
0.0859
0.533
0.565
0.565
0.601
0.601
0.601
0.663
0.672
0.750
0.827
0.827
0.882
0.882
1.39
1.65
1.88
2.04
2.04
2.52
•7 22
5.81
5.81
7.47
7.47
32.0
32.4
112




























10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
5
5
5
5
5
5
5
5
5
5
5
5
5
5
10
10
10
10
10
10
10
5
5
10
10
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
10
7
6
5
5
7
7
7
6
6
6
6
6
7
7
6
6
10
7
7
6
10
6
6
7
7
7
7
10
4
9
4
8
1
8
4
9
4
8
4
8
4
8
4
4
1
4
8
4
1
8
4
4
4
4
1
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
10
1
1
1
10
1
8
1
1
1
1
1
1
6
1
1
1
1
1
1
1
1
1
1
1
3
1
1
6
10
10
10
6
6
6
10
10
10
10
10
6
6
10
10
10
3
3
10
10
10
10
10
10
10
10
3
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
65
64
58
62
62
60
63
64
59
63
59
63
56
65
64
64
65
58
62
64
65
63
59
65
65
62
57
56
Eco-SSLfor Arsenic
March 2005

-------
                                                                   Appendix 6.1  Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
                                                                                                                 Arsenic
                                                                                                               Page 4 of 4
Ref
"3
167
168
169
170
171
172
173
174
175
176
177
178
179
Z;
15160
14543
14570
14556
14569
15397
15358
15324
15033
14543
14543
14593
15198

c
Hughes and Thompson, 1 996
Healyetal., 1998
Fuentesetal., 1981
Savabieasfahani et al, 1998
Fowler etal., 1977
Schiller et al, 1977
Fowler and Woods 1 979
Schiller etal 1981
Chaudhuri et al, 1999
Healyetal., 1998
Healyetal., 1998
Valdonenetal., 1983
Coboetal 1995
Exposure
S
1
1
g
u
S
Sodium arsenate heptahydrate
Sodium arsenate heptahydrate
Arsenic trioxide
Sodium arsenite
Sodium arsenate
Sodium arsonate
Sodium arsenate
Sodium arsenate
Sodium arsenate
Sodium arsenate heptahydrate
Sodium arsenate heptahydrate
Sodium arsenite
AS203

100
100
61.01
57.69
100
100
100
100
100
100
100
100
37.9
.1
I
H
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Cotton rat (Sigmodon hispidus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus}
Mouse (Mus musculus )
Mouse (Mus musculus )
Rat (Rattus norvegicus}
Rat (Rattus norvegicus~)
Phase #
1
1
1
1
1
1
1
1
1
2
2
i
i
# of Cone/ Doses
3
3
3
3
4
4
4
2
2
3
3
2
2
1
o
Q
1
o
O
0/0.014/1.4
0/8.5/827
0/4/12
0/0.088/0.15
0/20/40/85
0/20/40/85
0/20/40/85
0/40
0/0.05/0.10/0.30/3.0
0/8.5/827
0/8.5/827
0/0.1
0/0.295
Cone/Dose Units
mg/L
ug/kg bw/d
mg/L
mg/org/d
mg/L
mg/L
mg/L
mg/L
g/L
ug/kg bw/d
ug/kg bw/d
g/L
mg/g bw
Wet Weight Reported?
N
N
N
N
N
N
N
N
Y
N
N
N
N
Percent Moisture

na

na
na




na
na


>^
c
3
C
^o
«
"E.
Q.
ADL
ADL
ADL
ADL
ADL
NR
DLY
ADL
DLY
ADL
ADL
ADL
ADL
Method of Analyses
U
U
U
u
u
u
u
u
u
u
u
u
u
Route of Exposure
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
DR
Exposure Duration
28
32
3
4
6
3
6
3
40
32
32
11
8
'5
c
o
n
d
d
mo
w
w
w
w
w
d
d
d
d
w
&
•3
96
76
45
NR
NR
NR
NR
NR
4
76
76
3
NR
Age Units
d
d
d
NR
NR
NR
NR
NR
w
d
d
mo
NR
Lifestage
SM
JV
JV
AD
JV
AD
JV
AD
JV
JV
JV
JV
AD
x
F
M
F
M
M
M
M
M
M
M
M
M
M

Control Type
C
C
C
c
c
c
c
c
c
c
c
c
c

o
H
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Effects
General Effect Group
BIO
BIO
BIO
BEH
BIO
BIO
BIO
BIO
BIO
BIO
BEH
BIO
BIO
Effect Type
CHM
ENZ
ENZ
FOB
ENZ
ENZ
ENZ
ENZ
ENZ
ENZ
FOB
ENZ
CHM
3
TRIG
GENZ
CCOX
FCNS
MAOA
GENZ
MAOA
ALPH
GLRE
GENZ
WCON
ACHE
GLUC
Response Site
PL
TE
LI
WO
LI
LI
LI
UR
BR
TE
WO
NE
BL
H
Z;
^i
i
a













Conversion to mg/kg bw/day
Study LOAEL
0.0140
8.50
4.0
0.0880
20.0
20.0
20.0
40.0
0.0500
6.5
6.5
0.100
0.295
Body Weight Reported?
Y
N
N
Y
Y
Y
Y
N
Y
N
N
Y
Y
Body Weight in kg
0.0793
0.0316
0.204
0.144
0.340
0.2650
0.0267
0.510
0.1100
0.0316
0.0316
0.313
0.338
Ingestion Rate Reported?
Y
Y
N
Y
N
N
N
N
N
Y
Y
N
N
Ingestion Rate in kg or L/day
0.0049
na
0.02368
0.01530
0.03749
0.02996
0.003801
0.05401
0.01358
na
na
0.03480
0.03730
Result
^
BJD
^S_
H
Z;













LOAEL Dose (mg/kg/day)
0.00086
0.00850
0.283
0.353
2.22
2.26
2.84
4.24
6.50
6.5
6.5
11.1
112
Data Evaluation Score
3
C3
fi
10
10
10
10
10
10
10
10
10
10
10
10
10
Dose Route
5
5
5
5
5
5
5
5
5
5
5
5
5
Test Concentrations
5
5
5
5
5
5
5
5
5
5
5
5
5
Chemical form
10
10
10
10
10
10
10
10
10
10
10
10
10
Dose Quantification
7
6
5
7
6
6
6
5
6
6
6
6
10
Endpoint
1
1
1
4
1
1
1
1
1
1
4
1
1
BJD
C
1
n
4
4
4
4
4
4
4
4
4
4
4
4
4
Statistical Power
10
10
10
10
10
10
10
10
10
10
1
10
10
Exposure Duration
6
10
10
6
10
6
10
3
10
10
10
10
3
Test Conditions
4
4
4
4
4
4
4
4
4
4
4
4
4
3
o
H
62
65
64
65
65
61
65
57
65
65
59
65
62
•ailable from Attachment 4-3 of the Eco-SSL guidance (U.S. EPA 2003).
   Eco-SSLfor Arsenic
March 2005

-------