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             Research at the
             U.S. Environmental
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             EPA Progress Report, 2012
             Office of Research and Development

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Innovation Today  for a Sustainable  Tomorrow
A message from Lek Kadeli
Principal Deputy Assistant Administrator
U.S. EPA Office of Research and Development

This report highlights just a small sample of the
research results that the scientists and engineers
at the U.S. Environmental Protection Agency's
Office of Research and Development delivered
in support of the American people in 2012.
While just a snapshot, it reflects the enormous
positive impact of what a group of dedicated,
highly-skilled, and passionate researchers can
accomplish when they work together to cultivate
an atmosphere of innovation and common
purpose in providing solutions to environmental
health issues.
No other environmental research organization in
the world offers the collective depth and breadth
of expertise represented by EPA's research staff.
From assessing the promise and potential risks of
emerging technologies using tiny nanoparticles
thousands of times smaller than the width of a
human hair, to exploring the dynamics and far-
reaching challenges of global climate change,
EPA brings together experts from a diversity of
environmental and human health fields.
Collectively, this body of experts, together with
partners throughout the scientific community,
provide the firm, scientific foundation the
Agency needs to fulfill its mission on behalf of the
American people: to safeguard human health
and protect the environment.
EPA researchers are at the forefront of a
movement to advance environmental and
human health science into the next generation.
Their goal is not only to support efforts to
reduce pollution and lower the risks posed by
environmental exposure and contamination, but
to advance the science needed to achieve a
more sustainable and  prosperous future.
In doing so,  they are helping to fundamentally
change the business of protecting human
health and the environment from one focused
on what should not be done, to one based on
growth and opportunity. Together with their
partners, EPA researchers are part of a growing
community of scientists and engineers embracing
an entrepreneurial spirit aimed at delivering the
knowledge, tools, and solutions needed to meet
today's most pressing environmental challenges in
ways that simultaneously spark economic growth
and lay the groundwork for the a new wave of
American jobs.
This spirit of innovation is exemplified throughout
this report, which highlights some of the research
results and impacts achieved by EPA scientists
and engineers and their partners during 2012. A
few examples follow.
   •  Developing remote, mobile air monitoring
     sensors and technologies that will improve
     local air quality monitoring and are
     expected to help oil refineries and other
     industries save some $500 million over
     the next  ten years. (See New Technology
     to Improve Local Air Quality Monitoring,
     Reduce Costs.)

   •  Working with partners from the Department
     of Health and Human Services to launch
     the "My Air, My Health" initiative. My
     Air, My Health provided the incentive to
     inventors, software and app developers,
     and engineers to develop personal, portable
     sensors for air quality and human health.
     (See Sparking Innovation for Clean Air).

   •  Testing a novel, proof-of-concept coastal
     water quality monitoring system that taps
     data gathered from the International Space
     Station's Hyperspectral Imager for Coastal
     Ocean (HICO) through an EPA Pathfinder
     Innovation Project. (See Supporting
     Innovation.)

   •  Advancing the science and engineering

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Innovation Today for a  Sustainable Tomorrow, continued
    of "green infrastructure" techniques such
    as rain gardens, rain barrels, and green
    roofs that mimic natural conditions to help
    urban water systems develop new ways
    to reduce stormwater and remove excess
    nutrients from runoff. This work will help
    communities improve local waterways while
    avoiding costly upgrades and replacements
    to sewer systems and other "gray"
    stormwater infrastructure. (See Tapping
    Green Infrastructure and A Tool for Urban
    Stormwater Management.)

    Working with collaborators from Rutgers
    University and a New Jersey Department
    of Environmental Protection team to
    use a remote-controlled, submarine-like
    "autonomous underwater vehicle" to
    monitor water quality off the coast of New
    Jersey,  helping collect important data
    while reducing costly helicopter flights. (See
    Gliding beneath the Surface.)

    Developing new tools to help communities
    protect the health of their residents while
    advancing a more sustainable future, such
    as a sophisticated geographic information-
    based mapping tool  called the EnviroAtlas
    (see  Developing the EnviroAtlas to Support
    Community Decisions), and an on-line
    tool that helps illustrate the connections
    between natural ecosystems and human
    health. (See The Eco-Health Relationship
    Browser.)

    Combining advances in exposure science,
    biology, mathematical and computer
    modeling, and computer technology
    to advance the EPA's Computational
    Toxicology research and advance new,
    efficient, and fast high-throughput screening
    efforts.  (See EPA's Computational Toxicology
    Research; Chemical Evaluation Dashboards
    for Decision Makers, and ToxCast Partnership
     to Advance Chemical Testing, Reduce
     Animal Testing).

   • Growing EPA's widely-used Integrated Risk
     Information System ("IRIS") Program with
     a progress report to the U.S. Congress,
     highlighting continued improvements such
     as proactive stakeholder engagement
     and increased transparency, and
     the completion of several critical IRIS
     assessments, including dioxin (noncancer)
     and tetrachloroethylene (perc). (See
     Growing IRIS: Advancing EPA's Integrated
     Risk Information System.)

   • Enhancing the nation's ability to detect,
     respond to, and recover from a deliberate
     or accidental release of chemical,
     biological, or radiological agents through
     updates and improvements to tools such
     as I-WASTE and the Wide Area Recovery
     and Resiliency Program (see Supporting
     Emergency Response and Recovery),
     and the Selected Analytical Methods for
     Environmental Remediation and Recovery.
     (See Read to Respond: Improving the
     Nation's Emergency Preparedness).
EPA's overall research strategy unites six
complementary, highly-coordinated and
Transdisciplinary research  programs: Air,
Climate, and Energy; Sustainable and Healthy
Communities; Safe and Sustainable Water
Resources; Chemical Safety for Sustainability;
Human Health Risk Assessment; and Homeland
Security Research.
This report highlights some of the many
accomplishments EPA researchers and their
partners have achieved working together across
these programs throughout 2012. This report is
dedicated to their service and exemplifies the
innovative work they do everyday to support the
American people and advance a healthy and
sustainable future for the nation.

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                                                                                  PageS
Table of Contents
    Air, Climate, and Energy Research	
    Safe and Sustainable Water Resources Research.
    Sustainable and Healthy Communities Research..
    Chemical Safety for Sustainability Research	
    Human Health Risk Assessment Research	
    Collaborating with Partners	
    Homeland Security Research	,
...6
. 17
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.49
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Page 6

  Air, Climate, and Energy
  American communities face health and
  environmental challenges from air pollution and
  the growing effects of climate change, both of
  which are intricately linked to the choices we
  make about energy production and use.

  Improving air quality, reducing greenhouse gas
  emissions, and developing strategies to help
  communities and individuals address climate
  change are central to EPA's mission to protect
  human health and the environment.

  EPA's Air, Climate, and Energy research program
  examines the interplay among air pollution,
climate change, and energy use and production
to develop innovative and sustainable solutions for
improving air quality and addressing global climate
change. EPA research efforts in that regard support
policies with far-reaching health benefits across the
nation.

This section highlights a few of the research results
EPA researchers and their partners have achieved
in 2012 in the areas of air, climate, and energy.
    Learn More!

    For more information and to learn more about the scope and impact of EPA Air, Climate, and Energy
    research, please visit: www.epa.gov/research/airscience/.

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EPA research provides new insights into how pollution affects cardiovascular health.
    Protecting Cardiovascular  Health from Air  Pollution
    EPA scientists and grantees are making important
    new discoveries about the links between air
    pollution and cardiovascular health, part of the
    Agency's commitment to protecting human
    health. The research is giving medical experts
    new insights into how pollution affects the human
    cardiovascular system, including the finding that
    a combination of pollutants can cause much
    greater health problems that just a single agent
    alone.

    In 2012, EPA and EPA-funded studies
    revealed important insights into the link
    between particulate matter air pollution and
    cardiovascular health, including the following.

       •  A team of EPA-supported epidemiologists
        from Harvard and Brown Universities
        examined the medical records of 1,700
        stroke patients  in the Boston area over a 10-
        year period, and compared  them to hourly
        measurements of fine particle air pollution.
        They found a link between the pollution and
        an increased risk of ischemic strokes (the
        kind that occur when blood vessels to the
        brain are blocked).
    • EPA scientists collaborated with researchers
     from Duke University to find that people
     exposed to a combination of particulate
     matter and nitrogen dioxide may suffer
     worse health effects than just particulate
     matter alone.

   • In a study by EPA scientists, researchers
     found the potential for omega-3 fatty
     acids to protect the cardiovascular system
     from the harmful effects of fine particulate
     matter.

EPA scientists also advanced the understanding
of the link between cardiovascular health
and another air pollutant: ground level ozone.
The scientists discovered links between ozone
exposure and key indicators of cardiovascular
health, including changes in heart rhythm,
increased levels of an inflammation marker,
and decreases in compounds that help dissolve
artery-clogging blood clots. While previous
studies had shown statistical associations
between ozone exposure and such health
problems, the EPA research identified a
biologically-based explanation for these effects.

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EPA modified this electric-powered car with state-of-the-art technology to measure levels of different air pollutants along major
roadways and other pollution source locations.
   New Technology to Improve Local
   Air Quality Monitoring,  Reduce Costs
    In 2012, EPA scientists and engineers continued to
    advance the use and development of innovative
    technologies for researching, monitoring, and
    managing air pollution. The research is providing
    new, low-cost capabilities to measure emissions
    near industry, roadways and other areas
    where air pollution may be a concern but has
    traditionally been difficult to study.

    For example, in Wyoming, EPA researchers
    mounted air sensors on a vehicle to create a
    mobile monitoring platform for use along oil and
    gas pipelines. The device relays real-time data
    to occupants in the vehicle that they can use
    to identify spikes in emissions that could identify
    leaks.

    In a similar project, EPA researchers used an
    electric-powered, modified vehicle or "air sniffing
    car" equipped with air monitoring technology to
    quantify emissions profiles along major roadways
    and study the potential health impact that traffic
poses to those living, working, or going to school
near major highways.

In addition to mobile air monitors, EPA
researchers introduced novel monitoring
approaches utilizing advanced stationary sensor
technology. For example, a new approach was
developed for monitoring air quality at petroleum
refineries to more rapidly detect and identify
leaks so that small problems can be found and
fixed. Referred to as fence line monitoring, the
system  uses a series of sensors mounted along a
facility's perimeter to capture emissions from all
processes occurring within the facility rather than
deploying more expensive monitoring devices
targeted at individual processes within the
facility.

The innovative, low-cost fenceline sampling
approach has support from EPA's Office of Air
and Radiation and partners in the industrial
sector because it offers a highly cost effective

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This mobile air monitoring device relays real-time data to occupants in the vehicle they can use to identify spikes in emissions that
could indicate leaks along oil and gas pipelines.
   approach to support a new refinery sector
   proposal under the Clean Air Act. The sensors
   are expected to result in significant savings at
   refineries and provide a more flexible compliance
   framework. The Agency estimates that industry will
   realize savings of some $500 million over 10 years
   in reduced compliance costs.

   The new technologies EPA is advancing show
   the promise of establishing low cost, round-the-
   clock monitoring capabilities that would serve
   as both an early warning  system for industry to
   stop potentially costly leaks and better protect
   neighboring communities from air pollution.
Improvements in stationary air sensor technology allow
remote sensors to scan for "chemical footprints " of emission
characteristics.

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Page 10
  Sparking Innovation for  Clean Air
                          My Air
                          My Health
                          U.S. Department of Health and Human Services
                          U.S. Environmental Protection Agency
   The My Air My Health competition challenged Americans to develop
   personal, portable sensors that measure air pollution and a person's
   physiological response to pollution.
  In addition to advancing its own innovative use
  of air monitoring technologies, EPA is mining
  the collective efforts of inventors, software and
  application ("app") developers, independent
  engineers, and other innovators to spark the
  development of the next generation of air
  pollution monitoring devices and technologies.

  The goal is to inspire the development of
  revolutionary, low-cost, accurate, and easy-
  to-use air monitors that will provide individual
  citizens and health protection professionals alike
  better pictures of local air quality, and support
  actions and decisions to protect public health.

  In June, 2012, EPA and the Department of Health
  and Human Services (HHS) launched the "My
  Air, My Health Challenge," a call to innovators
  to create personal, portable, near-real-time,
  location-specific systems to simultaneously
  monitor and report air pollutants and potentially
  related health parameters such as heart rate and
  breathing.

  On November 15, 2012 four finalists were selected
  from 39 proposals. The four projects and their
  teams were:
               Ultra-fine particle sensing
               devices that also measure
               respiratory function and vital
               signs.
               Mobile application and website
               to link exposures to carbon
               monoxide and fine particulate
               matter with heart rates and
               blood oxygen levels.
               "Smart" athletic clothing that
               measures airborne pollutants
               and relevant health metrics.
               Integrated modular air quality
               sensors, breathing games,
               and a software package that
               promote public sharing of
               health information.
Each received $15,000 to move their ideas from
the design phase to working prototype, one of
which will be selected as the overall winner and
receive a cash award of $100,000 in June 2013.

Agency researchers are also providing technical
support and evaluation to nine teams from
across the United States and Europe who have
developed portable sensors for continuous or
near-continuous nitrogen dioxide and ozone
monitoring.

This collaboration stemmed from the 2012 Apps
and Sensors for Air Pollution Monitoring Workshop,
which brought outside developers together with
EPA researchers. The EPA evaluation team will
issue a final report in summer 2013.

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  Leading the Way to Cleaner Cookstoves
EPA research on indoor cookstoves could benefit millions.
    For roughly half the world's population, the
    source for both cooking and keeping warm is a
    simple fire pit surrounded by three large stones
    arranged to keep a pot, grill, or cooking surface
    above the flames. For the people who rely on
    them, these simple and inexpensive "solid fuel"
    cookstoves do the job.

    They are also among the world's leading
    source of environmental death due to indoor
    air pollution. In its report, Global Health Risks:
    Mortality and burden of disease attributable to
selected major risks (World Health Organization,
2009, accessed December 2012 at http://bit.ly/
UjXvSp) the World Health Organization estimates
that indoor air pollution from typical household
fires for heating and cooking contributes to
nearly two million premature deaths annually.

"Indoor smoke from solid fuel causes about 21 %
of lower respiratory infection deaths worldwide,
35% of chronic obstructive pulmonary deaths
and about 3% of lung cancer deaths," the report
states.  And because women and children
typically spend more time in countries where
such cookstoves are used, they are the most
affected.

EPA engineers and scientists are helping to
lead an international effort to develop a inside
the home new generation of clean burning
cookstoves that will bring relief to those exposed
to cookstove emissions in the developing world.

In 2012, EPA research engineers and their
colleagues published results from the most
extensive independent study done to date
to analyze emissions and energy efficiency of
cookstoves. The researchers tested 22 different
cookstove designs, measuring emissions of air
pollutants that cause harmful health effects and
contribute to climate change, including carbon
monoxide, particulates, hydrocarbons, carbon
dioxide, methane,  and black carbon.

Results of the worldwide study revealed
considerable differences in the amount of air
pollutants emitted  and in energy efficiency.
Among the key findings, researchers found
that emissions from some advanced cookstove
technologies are significantly lower than the most
widely used "three-stone" open fire.

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A 2009 report by The World Health Organization estimates that the indoor air pollution from typical household cooking fires
contributes to nearly 2 million premature deaths annually.
  In addition to supporting the potential health
  benefits from developing new cookstove
  technologies, the ongoing research is providing
  important scientific insights into global climate
  change. Because traditional cookstoves account
  for approximately 20 percent of worldwide
  emissions of black carbon—a contributor to
  global climate change—they represent an
  important potential opportunity for taking action
  to address climate change.

  A third study currently underway will provide
  additional information on cookstoves, including
  solar cookers.  The work is supported by the
  EPA-led Partnership for Clean Indoor Air, now
  integrated with the Global Alliance for Clean
  Cookstoves, a United Nations Foundation
  initiative.

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Biodiesel is fuel derived from plants, animals, or other living organisms.
    Health Effects  of Biodiesel
    The potential benefits of biodiesel—fuels derived
    from plants, animals, or other living organisms—
    as a substitute for conventional fossil fuels are
    numerous: they can be produced domestically,
    are generally safe to handle, and are naturally
    biodegradable. The use of biodiesel fuels
    can both lower the nation's dependence on
    imported fossil fuels and convert waste streams,
    such as used cooking grease, into a marketable
    commodity sold to power vehicles or heat homes
    and businesses.

    But while the allure of biodiesel is powerful,
    important questions about the long-term impacts
    associated with its use are  largely unanswered.
    EPA researchers are working to solve that
    important knowledge gap, conducting studies to
    better understand the health effects of biodiesel,
    from producing the fuel, to burning it.

    In 2012, EPA researchers continued to advance
    work examining how biodiesel fuels burn, working
    to identify the amount and types of pollutants
    in biodiesel exhaust, and how the pollutants in
    those emissions might affect human health.

    Specifically, the researchers are looking to see
    if components of  biodiesel emissions are likely
to have properties that trigger adverse health
effects, including changes in gene structures,
lung and cardiac reactions such as altered
electrocardiograms (known commonly as EKG),
heart rate variability, blood pressure, and lung
function in both healthy, normal individuals and
those susceptible to health problems.

Another area of interest EPA researchers are
advancing is the potential health effects
of biodiesel blends, fuels that combine a
percentage of bio-based fuels with more
traditional petroleum diesel. Biodiesel fuel
sources and the amounts used to create
blends are a constantly moving  target because
innovative technologies and market forces can
dramatically change the fuel type or blend.
That work is developing the science needed to
quickly test and evaluate the potential health
and environmental impacts of emerging fuel
sources.

What EPA researchers are learning will provide
decision makers with critical information and
guide further research in the quest to develop
alternative fuel sources that do not have the
unintended consequences of harmful emissions.

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Research results provided key information used in the development of emission standards for industrial boilers, allowing for less
costly, more efficient ways for boiler owners and operators to reach safer emissions targets.
    Reducing Hazardous Air Pollutants
    from Industrial Boilers
    New studies conducted by EPA researchers in
    2012 are playing a critical role in Agency efforts
    to reduce hazardous air pollution while also
    making it easier and less costly for industries and
    boiler operators to comply with new National
    Emission Standard for Hazardous Air Pollutants
    (NESHAP) rules under the Clean Air Act.

    Research results provided key information used
    in the development of emission standards for
    industrial boilers that EPA estimates will have a
    significant impact on protecting public health:
    preventing 6,500 premature deaths and 4,000
    heart attacks a year starting in 2014. The rules are
    also expected to cut mercury emissions to the
    environment by as much as 90 percent.

    The research was conducted at the 1.2
    megawatt Multipollutant Control Research
    Facility at EPA's Research Triangle Park campus
    in North Carolina where engineers can burn
    coal, oil and gas under different operating
    conditions to test a variety of different pollutant
    control technologies. There, researchers tested
    air pollution control technologies for particulate
matter (PM) to determine if the technologies
might also be effective in reducing additional
pollutants regulated under the new boiler
NESHAP rules. The research produced quality
data that supports the use of PM as a surrogate
for regulating hazardous air pollutants.

Researchers also extensively tested another
control technology called Dry Sorbent Injection
(DSI) and showed its effectiveness in removing
hazardous air pollutants.

EPA's Office of Air and Radiation incorporated
the research findings into the development of the
NESHAP rules, allowing less costly, more efficient
ways for boiler owners and operators to reach
safer emissions targets.
                             EPA engineers at the 1.2
                             megawatt Multipollutant
                             Control Research Facility
                             in North Carolina can
                             burn coal, oil and gas
                             under different operating
                             conditions to test a variety
                               afferent pollutant
                                                                              control technologies.

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EPA scientists are building and advancing computer models that calculate scenarios of the potential impacts of climate change.

   Exploring Climate Change and Air Quality  Scenarios
    Predicting the likely impact that future climate
    change will have on air quality, the environment,
    and ecosystems is critical so that potentially
    damaging effects can be reduced.

    EPA scientists are building and advancing
    computer models that calculate scenarios of the
    potential impacts of climate change, helping
    the public, policymakers, and community and
    business leaders incorporate sound science into
    their decisions.

    Examples of work advanced during 2012 include:

      Climate change and land use: How will the
      complex interrelationships between land-use,
      such as housing density and development,
      and climate change drive environmental
      impacts in air and water quality, human
      health, ecosystems, and other environmental
      parameters?  Increased  knowledge of the
      dynamic connections between climate
      change and land use will help local
      communities better prepare and make
      important decisions today.
EPA's Integrated Climate and Land Use
Scenarios (ICLUS) project is providing just that
kind of information. ICLUS is an online tool and
model that enables researchers to tap existing
climate change science to run models that
calculate potential environmental scenarios
related to the connections between climate
change and U.S. land use patterns.

In January of 2012, ICLUS researchers released
data for each region in the contiguous
United States to support the National Climate
Assessment, a periodic report produced by
the U.S. Global Change Research Program
and delivered to the President and U.S.
Congress.

Reducing pollution from the cement industry
sector: EPA modelers are developing the
Industrial Sector Integrated Solutions (ISIS)
model to help industries better evaluate
pollution reduction strategies. The model
provides sophisticated calculations to
illustrate the trade off and benefits of how
various options and changes in operations will

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affect multiple pollutants simultaneously, and
how changes in emissions policy could affect
production. The goal with ISIS is to present the
optimal cost-effective controls needed to
meet emissions reduction requirements.

EPA researchers completed the first ISIS model
for the cement industry sector. It allowed
the agency to better evaluate impacts on
domestic and international competitiveness
as well as plant-by-plant projections of likely
control technology installations.

Exploring scenarios for complex environmental
decisions: An EPA team combined
components of several existing models to
develop Geos-CHEM LIDORT Integrated
with MARKAL for the Purpose of Scenario
Exploration (GLIMPSE). This sophisticated
decision-support tool examines the impacts
of complex environmental decisions involving
air quality, climate change, ecosystems, and
energy production. For example, GLIMPSE
can be used to determine the best strategy to
simultaneously address black carbon emissions
to reduce health effects while mitigating
climate change impacts.

The model is designed to be fast and
comprehensive allowing decision makers to
explore a range of options to assess multiple
environmental goals such as improved air
quality, climate change mitigation and
ecosystem conservation.
Climate Change and

Human Health

In addition to advancing climate models, EPA
researchers are exploring the impact that
an increase in events such as heat waves,
flooding, and poor air quality will have on the
public, particularly vulnerable populations such
as older adults.

EPA research is providing crucial information
that can be used to better prepare and
protect the public from a changing climate.
Important published studies in 2012 include:

•  EPA scientists conducted a review of the
   latest published research demographics,
   relevant climate stressors, and factors
   contributing to the vulnerability of older
   adults to those stressors. The study
   confirmed previous findings that older
   Americans are likely to be especially
   vulnerable to stressors associated with cli-
   mate change.
•  EPA scientists provided a better
   understanding of the potential range of
   estimated ozone-related human health
   impacts brought on by climate change.
   Through the use of multiple models,
   epidemiological studies, and population
   projections, the study was among the
   first to explicitly explore the uncertainty
   surrounding assessment of these impacts.
          -  MS.7:
                     Older adults may be among the
                     least able to cope with impacts of
                     climate change.

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Safe and Sustainable  Water  Resources
Across the nation, people are placing increased
demands on the finite water resources that supply
precious drinking water, support healthy aquatic
ecosystems, and fill important societal and
economic needs, including energy, agriculture,
and industrial production.

EPA's Safe and Sustainable Water Resources
research program provides the science and
innovative technologies that the Agency—and the
nation—need to maintain drinking water sources
and systems, as well as to protect the chemical,
physical, and biological integrity of our waters.
EPA scientists and engineers, together with their
research partners, are addressing 21st century
challenges to water supplies and infrastructures by
integrating research across social, environmental,
and economic disciplines. Together they are
working to provide lasting, sustainable solutions to
those challenges.

This section highlights a few of the research results
EPA researchers and their partners achieved
in 2012 to support safe and sustainable water
resources.
  Learn More!
  For more information and to learn more about the scope and impact of EPA water research, please
  visit: www.epa .aov/research/waterscience/.

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 Page 18
A focused scientific study will determine the potential impacts,
if any, of hydraulic fracturing on drinking water resources.
                                                Hydraulic Fracturing

                                                Study:  Progress and  Outreach

                                                 Hydraulic fracturing is a technique used to
                                                 release natural gas and oil from underground
                                                 reservoirs. EPA is conducting a focused scientific
                                                 study to determine potential impacts, if any, of
                                                 hydraulic fracturing on drinking water resources.
                                                 The study is looking at the full cycle of water as it
                                                 is used in hydraulic fracturing.

                                                 In December, 2012, EPA released its first hydraulic
                                                 fracturing progress report, Study of the Potential
                                                 Impacts of Hydraulic Fracturing on Drinking  Water
                                                 Resources. The report describes 18 research
                                                 projects undertaken as part of the study and
                                                 summarizes the current status of each project.
                                                 While the progress report outlines work currently
                                                 underway, it does not draw conclusions about
                                                 the potential impact of hydraulic fracturing
                                                 on drinking water resources. A draft report,
                                                 expected in late 2014, will synthesize results  and
                                                 address the study's research questions. The
                                                 report has been designated a Highly Influential
                                                 Scientific Assessment, meaning it will receive the
                                                 highest level of peer review in accordance with
                                                 EPA's Peer Review Handbook.

                                                 In 2012, EPA also announced an enhanced
                                                 technical engagement and stakeholder
                                                 outreach effort regarding the hydraulic
                                                 fracturing study.  EPA is taking several steps  to
                                                 meet its stakeholder engagement goals:

                                                   1. Increase technical engagement with the
                                                     stakeholder community to ensure that EPA
                                                     has ongoing access to a broad range of
                                                     expertise and data outside the Agency. Five
                                                     technical roundtables, held in November,
                                                     2012, focused on each stage of the water
                                                     cycle as pertains to hydraulic fracturing.
                                                     EPA will host in-depth technical workshops

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1. Water
Acquisition
    4
2. Chemical
Mixing
 L
        4. Flowback and
        Produced Water
3. Well  (Wastewaters)
Injection
 The five stages of the water cycle as pertains to the hydraulic fracturing process.
5. Wastewater
Treatment and
Waste Disposal
                                                                                              Page 19
      to address specific issues raised during these
      roundtables in greater detail.

    2. Obtain feedback on projects undertaken
      as part of the study and ensure that EPA is
      up-to-date on changes in industry practices
      and technologies. The Agency is soliciting
      public involvement in identifying relevant
      data and scientific literature specific to
      inform the hydraulic fracturing study. In
      November, 2012, EPA published a  Request
      for Information in the Federal Register.
                                3. Improve public understanding of the goals
                                   and design of the study. In addition to the
                                   organized technical meetings, EPA will seek
                                   opportunities (such as association or state
                                   organization meetings) to provide  informal
                                   briefings and updates on the study to a
                                   diverse range of stakeholders, including
                                   states, non-governmental organizations
                                   (NGOs), academia, and industry.  EPA
                                   will also increase the frequency of  public
                                   webinars, hosting them after each technical
                                   meeting.
                                                               Hydraulic Fracturing Chemicals

                                                               Included in EPA's hydraulic fracturing
                                                               progress report is a list of over 1000
                                                               chemicals associated with hydraulic
                                                               fracturing processes. EPA researchers
                                                               curated and reconciled multiple EPA,
                                                               industry, and public chemical lists to
                                                               produce this consolidated inventory of
                                                               unique substances associated with
                                                               hydraulic fracturing.

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Page 20
  Bristol Bay, Alaska:

  Assessing Potential

  Mining Impacts on

  Salmon Ecosystems


  Bristol Bay watershed in southwestern Alaska
  supports the largest sockeye salmon fishery in
  the world, is home to 25 federally recognized
  tribal governments, and contains large mineral
  resources. The potential for large-scale mining
  activities in  the watershed has raised concerns
  about the impact of mining on the sustainability
  of Bristol Bay's world-class fisheries, and the
  future of some of the Alaska Native tribes in the
  watershed who have maintained a salmon-
  based culture and subsistence-based lifestyle for
  at least  4,000 years.

  This pristine  and unique watershed supports all
  five species of Pacific salmon and half of the
  world's sockeye salmon population. The fishery
  (commercial, recreational, subsistence) is
  valued at more than $365 million per year, with
  hunting  and sight-seeing bringing the total value
  to almost $500 million per year. The Bristol Bay
  watershed also holds large deposits of valuable
  minerals. One deposit—the Pebble Deposit—if
  fully developed, has the potential of becoming
  one of the largest mines of its type in the world.

  EPA received petitions from nine federally
  recognized tribes and other stakeholders
  expressing concern that the salmon fishery would
  be at risk from large-scale mining and asking that
  EPA take action to protect salmon populations
  affected by the Bay's Watershed. Other tribes
  and stakeholders who support development in
  the Bristol Bay watershed requested EPA take no
  action until a permitting process begins.

  In response to the petitions, EPA is conducting an
  assessment of the Bristol Bay Watershed to better
Approximately 50% of the world's production of sockeye salmon
comes from the Bristol Bay Watershed.


understand how future large-scale mining may
affect the salmon fishery. EPA will use the results
of the assessment to evaluate options for assuring
that the resources of Bristol Bay, are effectively
protected.

EPA's draft report, An Assessment of Potential
Mining Impacts on Salmon Ecosystems of Bristol
Bay, Alaska, was released in May 2012; it then
underwent a 60-day public comment period
and external peer review panel. The final report
is expected to be completed and publicly
available in 2013.
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Water pumped in and out of ship hulls to provide stability can introduce of non-native invasive species.

    Stemming the Tide  of Invasive Marine  Species
    In 2012, EPA scientists finalized an Atlas of non-
    native marine and estuarine species for the
    North Pacific Ocean. The Atlas provides a
    comprehensive reference to help biologists,
    marine and estuarine managers, and others
    identify species that were likely introduced by
    the release of ballast water—the water that ships
    pump in and out of their hulls to maintain stability.
    The Atlas provides key information for assessing
    which areas are prone to risk from invasive
    marine species, and identifies traits that make
    certain groups of species potentially disruptive
    when released outside their  natural range.

    In addition to the Atlas, EPA  researchers
    partnered with colleagues from the U.S. Coast
    Guard to develop new performance verification
    protocols to ensure that disinfection technologies
    and devices used by ships for destroying
    organisms in ballast water are effective. The
    test protocols were subsequently validated by
    independent tests conducted by engineers and
    scientists at the Naval Research Laboratory (NRL)
    in Key West, Florida.
This research is expected to help stem the tide of
economic and environmental impacts caused
by the release of invasive species in ballast water.
  The zebra mussel (Dreissena polymorpha) is native to Eastern
  Europe, but was discovered in the Great Lakes nearly 25 years
  ago.

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Rainwater runs off of roads into the sewer system.

    A Tool for Urban

    Storm Water Management

    Stormwater overflow presents a  big problem in
    many urban areas. Heavy rains send torrents of
    water running over pavement, rooftops, and all
    the other impervious surfaces that cover most
    city grounds. Not only does this excess water
    cause superficial flooding of roads and buildings,
    but it also floods city sewer systems. Combined
    sewer systems that collect municipal sewage and
    stormwater in a single pipe system can overflow
    during heavy rain resulting in 'combined sewer
    overflows' where sewage and other pollutants
    overflow into nearby waterways. EPA researchers
    are developing tools and strategies to help
    city planners, managers, and others address
    stormwater problems.

    EPA's Storm Water Management Model (SWMM)
    is used widely for planning, analysis and design
    related to stormwater runoff, combined sewers,
    sanitary sewers, and other drainage systems in
    urban areas. SWMM is a rainfall-runoff simulation
    model that gives users important information
    about local water patterns. This  helps inform
the design and implementation of natural and
"green" (such as rain gardens and green roofs)
as well as traditional "gray" (pipes) stormwater
management alternatives. This publicly available
model averages 2,000 downloads every month
and is often used as a core modeling engine by
municipalities.

EPA recently expanded SWMM (version 5) to
explicitly model the performance of specific
types of low impact development controls,
such as porous pavement, bio-retention areas
(e.g., rain gardens, and green roofs), infiltration
trenches, vegetative swales, and other forms
of green infrastructure (see  "Tapping Green
Infrastructure" on adjacent page). The updated
model allows engineers and planners to
accurately represent any combination of low
impact controls within a study area to determine
their effectiveness in managing stormwater and
combined sewer overflows.

The development of predictive modeling
tools like SWMM for the design of integrated
green and gray infrastructure for use in urban
watersheds is intended to improve resource
management, criteria development, and
regulatory decisions.
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Rain garden pilot project with monitoring equipment at the St. Francis Court Apartments in Cincinnati.
    Tapping Green Infrastructure
    EPA researchers are studying green infrastructure,
    water management techniques that tap or
    mimic natural conditions to achieve efficient,
    sustainable stormwater management systems.
    Examples of green infrastructure include: rain
    gardens, rain barrels, green roofs, cisterns,
    daylighted streams, and retention ponds. The
    environmentally-friendly techniques of green
    infrastructure present sustainable options for
    reducing urban water problems and health risks.

    The work will provide cities and local communities
    with tools and guidance they can use to combat
    water-quality issues such as flooding, combined
    sewer overflows, and nutrient impairment.

    With research ranging from soil analysis to best
    placement modeling, EPA researchers are
    working to inform city managers and decision-
    makers about green infrastructure practices.
    Research data are also used to inform the
    development and evaluation of stormwater
    modeling tools such as the Storm Water
    Management Model.
• Urban Soil Assessment: Researchers assessed
  characteristics of urban soils in various
  locations to inform the development of
  an Urban Soil Assessment Protocol. By
  accounting for how excess stormwater will (or
  will not) move through surface and deeper
  soils, this protocol helps direct communities
  when  and how to use green infrastructure in
  an economically feasible way.

• Guiding Green Infrastructure in Omaha: In
  collaboration with the City of Omaha and
  the Nebraska Department of Environmental
  Quality, EPA scientists analyzed soils and
  prepared monitoring equipment for the
  introduction of green infrastructure to
  selected sites througout the city. EPA is
                    •

            2010 URBAN SOILS ASSESSMENT
                 Rediscovering Your
               Community's Urban Soils
                                                     Soil core samples were taken at various urban soil
                                                     testing sites.

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Page 24
      Researchers dig up and examine a soil core for analysis at a potential
      green infrastructure site in Omaha.
     providing guidance on how the city and state
     can incorporate green infrastructure into their
     combined sewer overflow control plan. EPA will
     also work with the local U.S. Geological Survey
     (USGS) to establish monitoring sites around the
     green infrastructure installations to determine
     how well they perform with respect to water
     capture and infiltration.
     Daylighting Streams to Improve Water
     Quality: Researchers recently compared
     the effectiveness of buried streams (streams
     routed into underground pipes) versus open-
     air streams for removing harmful nitrogen from
     water systems. Early research results suggest
     that buried streams are less effective at
     removing nitrogen than daylighted streams—
     streams above ground and open to the air.
     These findings suggest that daylighting  streams
     could prove a sustainable method for nitrogen
     removal and improved water quality. The
     outcomes of this study and further research
     will be used to inform a new modeling tool
     for urban managers. This tool will help identify
     places within a city where daylighting streams
     would  be most effective.

     Monitoring Green Infrastructure: Green
     infrastructure pilot projects are underway
     in Cincinnati, Ohio, and EPA scientists are
     monitoring the hydrology (water flow patterns)
            Researchers sample an open-air
            stream (top) and a buried stream pipe
            (bottom).
  and water quality at select rain garden and
  permeable pavement sites. The Metropolitan
  Sewer District of Louisville, Kentucky is working
  with EPA scientists to develop a monitoring
  plan to demonstrate the performance of
  individual green infrastructure controls and the
  aggregated effectiveness of these measures
  on combined sewer flow. Additionally, EPA is
  monitoring the long-term performance of green
  infrastructure best management practices at
  the EPA facility in Edison, New Jersey.

• Cleveland's Vacant Lots: Based on technical
  guidance from EPA experts, Cleveland, Ohio
  has incorporated a green infrastructure pilot
  program into its combined sewer overflow
  consent decree. This program takes advantage
  of the city's vacant land, turning that land
  into green spaces that not only absorb excess
  stormwater, but also improve the social and
  economic fabric of neighborhoods historically
  lacking green space.

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This autonomous underwater vehicle can safely and efficiently collect water quality data.
    Gliding Beneath the Surface
    Low levels of dissolved oxygen (DO) in ocean
    environments have the potential to harm sea life
    and degrade the health of aquatic ecosystems.
    New Jersey's coastal waters have long suffered
    from low oxygen conditions, putting the state in
    violation of water quality standards.

    In order to improve understanding of the
    highly variable ocean processes that influence
    oxygen levels in New Jersey's  coastal zone, a
    collaborative team of researchers from New
    Jersey's Department of Environmental Protection
    and Rutgers University developed a robotic
    vehicle to investigate beneath the ocean
    surface. Supported by EPA's regional science
    programs, the team operated this autonomous
    underwater vehicle (AUV), named the "Slocum
    Glider" and evaluated its ability to capture data
    about coastal water quality efficiently.

    Dissolved oxygen levels have historically been
    measured based on infrequent sampling,
    providing imprecise results. In contrast, the AUV
    takes rapid-fire readings of dissolved oxygen,
    salinity, and temperature at various depths,
    resulting in a much more comprehensive
database for dissolved oxygen. The AUV also
goes where ships and scientists cannot safely go,
including sampling beneath Hurricane Irene, one
of the few times an AUV captured data during
such a powerful storm.

The Slocum Glider was relaunched on July 10,
2012 to collect water quality readings along
more than 185 miles of the NJ coastline. This
experiment monitored coastal conditions
during the peak of summer, when a transitional,
mixed layer of water separates warmer surface
waters from colder layers below. Under certain
conditions, this layering of the water column can
lead to poor water quality and be harmful to
humans and aquatic life.

Information gathered by the Slocum Glider is
informing New Jersey's upcoming re-evaluation
of impaired coastal waters. Use of this glider
technology has already allowed EPA's regional
office (Region 2) in New York to divest from its
previous practice of monitoring dissolved oxygen
by helicopter, which was a costly approach with
limited results.

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EPA's Virtual Beach software allows for real-time water quality monitoring at Wisconsin beaches.
    Real-time Beach Monitoring
    The principal cause for beach closings and
    advisories is water pollution caused by elevated
    levels of bacteria, primarily E. coll. which
    indicates human or animal waste contamination.
    However, by conventional methods,
    measurements of E. coll levels can take up to 24
    hours. By the time results are compiled, water-
    quality conditions may have already changed.
Bacteria indicative of human or animal waste is the principal
cause for beach closings.
To improve beach water monitoring, EPA
scientists developed Virtual Beach modeling
software. This tool, updated in March 2012, is
designed to predict pathogen indicator levels
at recreational beaches, giving water-quality
information in real-time or even before the
contamination occurs.

Using the Virtual Beach software, managers
can easily map their beach using an intuitive
graphical interface. By looking at data on the
local watershed, Virtual Beach's models can
find correlations between certain weather and
water conditions and bacterial outbreaks, giving
beach managers advanced warning of the
kinds of contamination events that lead to swim
advisories and beach  closures.

The Wisconsin Department of Natural Resources
(WDNR) partnered with EPA and the U.S.
Geological Survey (USGS) to tap EPA's Virtual
Beach software for real-time water monitoring
at Wisconsin beaches. The impact of that effort
was the creation of the Nowcast Program,

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                                                                                             Page 27
                                                                 ^ Swimcast
                                                                    Nowcast
                                                                    Nowcast (Operational/Testing)
                                                                    Forecast (Operational/Testing)
                                                                    Various (Development'Testing)
Anal map of the Great Lakes showing beaches currently under Nowcast or other water quality monitoring programs.
   which works with local public health departments
   along Wisconsin's Great Lakes coast to improve
   the timeliness, accuracy, and cost-effectiveness
   of water-quality monitoring at high-priority
   recreational beaches. The program creates
   and implements early-warning models that can
   predict the level of E. coli bacteria and the
   probability of exceeding water-quality guidelines
   in real-time.

   In 2011, two beaches piloting Nowcast models
   reduced the number of missed advisories by 20
   percent and reduced the number of incorrectly-
   posted advisories by 50 percent. As of June 2012,
   Nowcasts were being used to make management
   decisions at seven high-priority beaches on
   Lake Michigan. Models have been developed
   for an additional 21 beaches on Lake Michigan
   and Lake Superior by Wisconsin and the U.S.
   Geological Survey.


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 Page 28
                                   ' • * .!        '" ,
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Legacy sediment layers are visible in this Big Spring Run stream bank (Photo credit: Dr. Dorothy Merritts)


     Sediment Removal to Improve Water  Quality
     Excess sediments and nutrients, especially
     nitrogen and phosphorous, are a leading cause
     of water quality impairment in streams and
     wetlands throughout the nation, particularly in
     the mid-Atlantic region. Legacy sediments are
     the deposits of sediment and nutrients that built
     up as a result of historic mill dam construction.
     EPA scientists are researching the removal
     of legacy sediments as a cost-effective and
     sustainable means of reducing sediment and
     nutrient pollution in watersheds.

     Historic damming of streams and rivers led to a
     huge backup of sediment and the destruction
     of natural water and soil systems. Most of the
     dams are now abandoned, but as the natural
     water systems return, they threaten to release
     massive amounts of sediment and nutrients to
     downstream waters. EPA, in collaboration with
     federal, state, and academic partners, focused
                                                                          .

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                                                                                       Page 29
research efforts on Big Spring Run (BSR), a rural
stream in Lancaster County, Pennsylvania that is
impacted by legacy sediments.

Beginning in 2009, legacy sediments were
removed from Big Spring Run and buried
wetlands were exposed and reconnected to
the floodplain water system. Water quality and
geologic assessments of the area showed that
stream bank erosion was more extreme than
expected and nutrient levels were high in ground
and surface waters. Restoration is expected to
greatly reduce sediment transport and nutrient
contamination, especially because healthy
wetlands will naturally filter and convert harmful
excess nutrients out of the water system.

Restoration of Big Spring Run was completed in
September 2012. Researchers found that since
September, the plant community composition
at BSR has changed significantly, showing signs
of healthy wetlands. These early results point to
a promising method for protecting downstream
waters from further sediment and nutrient
pollution by the removal of legacy sediments
and the associated wetland restoration.

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 Page 30
One of two waste water treatment facilities at Ft. Riley, KS.
    Partnering to Achieve  "Net Zero"
    EPA supports a United States Army sustainability
    initiative—called Net Zero—to reduce energy,
    water and waste from Army facilities. This cross-
    agency collaboration is a test case for new
    technologies to improve efficiency and to
    minimize waste of resources. Technologies that
    prove successful through this partnership will
    serve as examples of tools that can benefit other
    communities across the United States and world-
    wide.

    The Net Zero-EPA collaboration began for
    EPA with the signing of a Memorandum of
    Understanding (MOU) between EPA and
    the Army. Two Army bases chosen to pilot
    this research collaboration are Fort Riley,
    Kansas and Joint Base Lewis-McChord  (JBLM),
    Washington. The initial focus is on water issues
    such as stormwater management, water reuse,
    monitoring aging water infrastructure for leaks,
and ways to improve efficiency.

In July, 2012, EPA scientists met with Army staff
at Fort Riley to discuss water infrastructure
challenges and specific technology needs of the
base. The site visit allowed an integrated project
team to prioritize needs and identify potential
                                                   EPA collaboration with the United States Army will reduce
                                                   waste and increase efficiency of Army facilities.

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projects. Project plans were drafted in the fall
and finalized in December, 2012.
                                                                                      Page 31
Projects that were drafted include:
 1. Perform assessment and introduce
   rehabilitation technologies that address the
   maintenance and upgrading of aging water
   infrastructure in a cost-effective manner
 2. Implement small-scale water reuse systems
   to significantly reduce the need for potable
   water use
 3. Facilitate a study to investigate education/
   outreach approaches focused on behavior
   and culture changes needed to reduce
   water consumption

Similar project planning is underway for Joint
Base Lewis-McChord, exploring stormwater
management that incorporates green
infrastructure approaches into current
stormwater systems and decontamination
techniques to improve understanding of handling
and treatment of waste water.

An additional MOU, signed with the U.S.
Department of Defense  in February, 2012,
complements the Army MOU, and expands EPA's
opportunities to promote and transfer technology
successes broadly to other communities and
additional military installations.
             POTABLE WATER

-
            HBB
Planned projects Include Introducing small-scale
water reuse systems to conserve potable water.

  Learn More about EPA Safe and Sustainable Water Research
  • Visit: www.epa.gov/research/waterscience/.
  • See the 2012 Water Research issue of EPA's Science Matters newsletter:  http://l .usa.gov/WgsrVb
  • Download a copy of EPA's Safe and Sustainable Water Resources Strategic Research Action Plan,
    2012-2016: www.epa.gov/research/docs/sswr-strap.pdf.

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The single largest Chesapeake Bay pollutant is excess nutrients, which come from wastewater treatment plants and stormwater
runoff, among other sources.
    Community-Based Chesapeake  Bay
    Stormwater Management
    Presidential Executive Order 13508 directs the
    federal government to lead efforts to restore
    and protect Chesapeake Bay, a body of
    water plagued by pollutants and poor water
    quality. The largest group of Bay pollutants is
    excess nutrients, which come from wastewater
    treatment plants and  runoff from cropland,
    urban and suburban areas, and other sources.
    To address the problem of nutrient pollution from
    urban stormwater runoff in the Bay area, EPA's
    Science to Achieve Results (STAR) grant program
    sought applications for applied research aimed
    at identifying pathways for effective and durable
    community-based stormwater management.

    In September, 2012, STAR announced a $700,000
    award to the University of Maryland to work with
    local communities to improve urban stormwater
    management in the Chesapeake Bay area.

    The awarded project, Sustainable Community
    Oriented Stormwater Management: A Sensible
    Strategy for the Chesapeake Bay, will use
innovative community involvement methods.
Maryland researchers will use information from
community member submissions and interviews
to create a model of troublesome stormwater
areas within the community. Using this model,
scientists and the community will collaborate to
develop improved and sustainable stormwater
management practices to reduce stormwater
pollution from hot spots, maintain long-term
water quality in Chesapeake Bay, and protect
the health of  the community.

In 2011, EPA awarded almost $2.5 million
dollars to Penn State University to open an
interdisciplinary research center that is studying
green infrastructure to improve water quality
in Chesapeake Bay. The team that runs this
center works  to combine decision making
and green infrastructure issues to improve
stormwater management. The Penn State and
Maryland teams plan to work together and
share information as they both strive to improve
Chesapeake Bay.

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                                                                                   V
Sustainable and Healthy  Communities
EPA's Sustainable and Healthy Communities
research program works to help communities
meet their current needs in ways that protect the
environment and enhance human health over the
long term, so that future generations can meet
their needs, too.

Working closely with community stakeholders
and other decision  makers to identify the
information, science, and technologies they
require, EPA scientists use a holistic approach to
advance research that reflects the three pillars
of sustainability: economy, society, and the
environment. The work provides decision-support
tools and information that communities need
to develop proactive, strategic solutions for a
prosperous and environmentally sustainable future.

This section highlights a few of the research results
EPA researchers and their partners have achieved
in 2012 to support sustainable and healthy
communities.
  Learn More!

  For more information about the scope and impact of EPA research to support sustainable and healthy
  communities, please visit:
  •  EPA Sustainability: www.<
    Download a copy of Sustainable and Healthy Communities Strategic Research Action Plan,
    2012-2016: www.eDa.aov/research/docs/shc-straD.Ddf.

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Satellite imaging shows a smoke plume from the 2008 North Carolina peat fire.

    Studying the  Connections between Wildfire
    Smoke and Community Health
    More than 73,000 wildfires broke out in the United
    States in 2011, and that figure is expected to rise
    with climate change. Results from a new EPA
    study will help state agencies and the EPA Office
    of Air and Radiation identify and assist vulnerable
    communities and individuals who are highly
    susceptible to air pollutants—especially those
    released by wildfires.

    Researchers compared different health factors
    in counties in eastern North Carolina  that were
    exposed to smoke from a 2008 peat wildfire in
    Pocosin Lakes National Wildlife Refuge. The peer-
    reviewed study shows that poorer residents had
    a much higher chance of getting sick from air
    pollutants caused by the wildfire.

    During the fire, burning deposits of partially
    decayed vegetation released smoke and haze
    for several weeks. One particularly bad episode
    left dense ground-level smoke covering most
    of the eastern and central parts of the state for
    approximately three days. Researchers found
that during this time, significantly more people
than usual visited hospital emergency rooms for
heart and lung complications linked to wildfire
smoke inhalation.

Using data collected from 98 percent of all
emergency departments in North Carolina,
researchers examined health behaviors such as
excessive alcohol consumption, access to clinical
care, socio-economic status and unemployment
rates, among other factors. By analyzing
these factors for patients who visited  hospitals
following the 2008 fire, researchers found that a
community's low socio-economic status was the
best  indicator of risk for worsening asthma and
heart failure after smoke exposure.

Results from this study, titled Cardio-respiratory
Outcomes Associated with Exposure  to Wildfire
Smoke are Modified by Measures of Community
Health, were published in the September
2012 online edition of the scientific journal
Environmental Health.

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                                                                                           Page 35
 Protecting People  from Arsenic and Lead in  Soil
EPA research results in an effective way of protecting human
health while guiding clean-up activities at Superfund and other
contaminated sites.
A team of EPA scientists looked at the way the
digestive system takes in arsenic after exposure
to develop an innovative and efficient way to
determine the bioavailablility of arsenic and lead
in soils. They used that model to make a tool that
shows how much bioavailable arsenic is in soil.
The tool can detect how much arsenic is actually
toxic. The result is an effective way of protecting
human health while guiding cleanup activities at
superfund and other contaminated sites.

Use of the tool, still in its testing stage, has led to
significant cost savings at a number of regional
Superfund site offices and could ultimately help
EPA assess human exposure to soil contaminants in
a much more cost effective way.
    Toxics and human digestion may sound like a
    daunting pair, but EPA researchers have found
    a way to create a computer model of the
    digestive system and the way it absorbs arsenic
    to create a powerful science tool. This device is
    one of several innovative tools EPA researchers
    are developing to better estimate human
    exposure to arsenic and lead in soil.

    Currently, mitigating the dangers of locations
    with contaminated soils means using heavy
    equipment to remove the entire top layer
    and hauling the soil to a landfill designed for
    hazardous material. Then the soil  is treated and
    all the toxins are removed. This method, although
    effective, is expensive and inefficient because
    not all forms of soil contaminants  are harmful to
    animals and humans, or "bioavailable" (can be
    absorbed into the bloodstream).  Arsenic and
    lead are toxic only in this bioavailable form.
   i,'

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                                                                                  .
The EnviroAtlas maps ecosystem services such as air filtration provided by these urban trees.

    Developing the  "EnviroAtlas" to Support
    Community Decisions
    EPA researchers are developing the EnviroAtlas,
    a Web-based mapping tool that will provide
    users with an easy-to-use, visual way to explore
    and better understand the benefits of natural
    ecosystems and how they can be conserved
    and enhanced for a sustainable future.

    The tool provides information community
    decision makers need to make strategic choices
    about development and environmental policy,
    based on a more comprehensive understanding
    of the interactions between human activities and
    the many goods and amenities (often referred to
    as "ecosystem services") that people derive from
    nature.

    The EnviroAtlas is a Web-based mapping
    application that allows users to view and analyze
    multiple ecosystem services in a specific region
    such as drinking water supplies or recreational
    and cultural amenities. Decision-makers can use
    the Atlas to forecast what will happen to these
natural resources under future population growth
and climate change.

EPA researchers are working with partner
agencies to develop this online, interactive
decision-support tool. The EnviroAtlas
collaborators currently include the Natural
Resources Conservation Service and U.S. Forest
Service (both part of the U. S. Department
of Agriculture), the U.S. Geological Survey
(Department of the Interior), the National
Geographic Society, the nonprofit organization
NatureServe, and  the City College of New York.
Other organizations working with EPA researchers
to take advantage of the information provided in
the EnviroAtlas include:

   • The Strategic Highway Research Program
    2 of the National Academy of Sciences
    which is exploring the use of the Atlas for
    sustainable highway planning.

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     • LcmdScope America, an online resource
       for the land-protection community, now
       includes multiple data layers from the
       EnviroAtlas.

  Also, the EnviroAtlas will most likely be a major
  resource for the forthcoming EcolNFORMA,
  an online digital information system on
  ecosystem services and biodiversity currently in
  development. The development of EcolNFORMA
  was recommended in a report by the President's
  Council of Advisors on Science and Technology.

  The EnviroAtlas will also feature detailed data
  on 50 to 250 cities and towns across the country.
  The community component of EnviroAtlas, will
  provide fine-scale information linking human
  health and well-being to environmental
  conditions such as urban heat islands, near-road
  pollution, and other quality of life indicators.

  Ongoing development of the EnviroAtlas in 2012
  focused heavily on this community component.
  The EnviroAtlas development team worked with
  all 10 EPA regional offices to identify communities
  for the next phase of high-resolution analyses,
  and current plans include six tribal communities.
  The first community pilot project is for Durham,
  North Carolina (see  "The Durham Pilot" on this
  page).

  In 2012, the EnviroAtlas became available to
  EPA's partners (other federal agencies and
  several universities).  Public access to the tool is
  planned for 2013.


                           &/  * €*e>-
                                   "S*

                                           >
This aerial map of downtown Portland, ME, from the
EnviroAtlas, is classified into open spaces (greens), impervious
surfaces (pinks), and water (blue).
In September, EPA scientists ran a field monitoring project
with Durham high school students in environmental science
advanced placement classes. The goal was to engage students
in participatory research and improve understanding about the
extent to which tree cover reduces the urban heat island effect.
Pictured here, students learned to use temperature sensors at
EPA's research campus in Research Triangle Park, NC.
  The Durham Pilot

  In 2012, EPA completed the EnviroAtlas
  community component for the city of Durham,
  North Carolina. Working with the Durham
  community, researchers created map layers
  for supply and demand of ecosystem services,
  and societal implications for the city's natural
  resources.

  Local partners in Durham will use EPA research
  products like the EnviroAtlas to diagnose
  environmental problems, analyze alternatives,
  and track the performance of implemented
  management approaches. Tools and approaches
  developed in Durham will be transferable to other
  communities around the country.

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Shade trees in urban areas contribute to multiple ecosystem services such as heat mitigation and air filtration while also encouraging
engagement with nature and other benefits as suggested by the Eco-Health Relationship Browser.
     The Eco-Health Relationship Browser
    Ecosystem services are the goods and services
    people derive from the natural environment,
    such as clean water, fertile soil for crop
    production, pollination, and flood control and
    water filtration from wetlands. While many
    of these services and their benefits are easily
    recognizable, many, such as air filtration, are not,
    and as a result are easy to undervalue.

    To help communities and others better account
    for and protect the benefits they derive from the
    environment, in 2012 EPA researchers developed
    an Eco-Health Relationship Browser. The browser
    is designed to increase our understanding of the
    nation's ecosystems, the services they provide,
    and how those services benefit public health and
    well being.

    The publicly-available, Web-based browser uses
    a series of interactive "info-bubbles" to help users
    easily identify linkages between human health
    and ecosystem services. For example, forests
    are ecosystems that contribute to cleaner air
through natural air filtration, and air pollution has
been shown to be connected to the incidence
of migraine headaches. Through this association,
changes in forest ecosystems could be linked to
frequency of migraines.

The info-bubbles also contain sidebar
descriptions that briefly explain the selected
topic and  pop-up boxes that illuminate
associated ecosystem service linkages, complete
with citations of relevant scientific studies about
the connections. A complete bibliography is also
available from the browser webpage.

The Eco-Health Relationship Browser is one new
tool in the Agency's efforts to better understand
and quantify connections between ecosystems,
ecosystem services, and human health. This
information is critical for decision makers as they
work to preserve and protect valuable and
interconnected assets and strive to ensure
sustainable and healthy communities.

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                                                                                          Page 39
A two-year EPA study investigated toxic vapors and radon concentrations in indoor air and underground soils near residences.

    EPA Science Supports Vapor Intrusion Guidance
    Most threats to people in buildings, such as fire,
    flood, hazardous spills, or structural damage,
    are dramatic and easy to identify. But while
    it may not be something worthy of coverage
    on the evening news, vapor intrusion—the
    contamination of indoor air by harmful gases,
    both naturally occurring (such as radon) or
    or resulting from chemical spills), that  migrate
    upward from the ground or ground water—also
    poses serious health risks.

    EPA scientists have provided measurements and
    analysis methods for a new guidance document
    to better evaluate the problems associated with
    toxic chemicals that seep into people's homes
    through vapor intrusion.

    During a two-year study, EPA scientists
    investigated spatial and seasonal changes in
    the concentrations of vapors, including volatile
    organic compounds (VOS) and radon in indoor
    air.

    The outcomes were published in October 2012 in
    a report titled, Fluctuation of Indoor Radon and
    VOC Concentrations Due to Seasonal Variations.
Results from the study, along with several
other documents and tools were compiled as
part of the Agency's Final Subsurface Vapor
Intrusion Guidance, made publicly available on
November 30, 2012.

This guidance document provides reliable ways
to measure vapor intrusion and answers questions
first posed in the 2002 EPA document on the
same topic. The results of the research and
guidance provide environmental managers and
others from EPA Regional Offices and states with
easy-to-understand ways to evaluate sites for
VOC vapor intrusion.

Additional ongoing EPA research on vapor
intrusion includes developing approaches for
measuring vapor impacts, evaluating sampling
tools to assess impacts at petroleum sites, and
modeling studies to better understand the
screening of certain vapor intrusion chemicals.
The suite of research supports efforts to develop
assessment approaches for contaminated sites
and buildings, and to inform multiple regulatory
efforts related to vapor intrusion issues.

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Two 55 gallon drums (in series) for sand filtration are always in service while the third is undergoing backwash. Daniel Concepcion,
a University of Puerto Rico student, completed his Masters Degree based on these drum sand filter studies.
     Water Systems  in Puerto Rico
     EPA researchers are customizing innovative water
     treatment systems to help better protect people
     living in small communities in Puerto Rico that
     currently rely on untreated sources of drinking
     water, making them susceptible to periodic
     outbreaks of waterborne diseases.

     To offer sustainable solutions to the water
     quality challenge, EPA scientists aimed to
     design treatment systems that could serve local
     populations. For example, they sought systems
     that would be inexpensive, fabricated from local
     parts and supplies, and easy to build, operate,
     and maintain—such as systems that could be
     operated via gravity or solar power.

     The researchers delivered. The result of their work
     was the creation of two "slow" sand  filtration
     systems constructed in a remote location in Rio
     Piedras. The systems not only provide a locally
     sustainable, clean drinking water supply, they
     also serve as demonstration and training centers
     for surrounding communities and water system
     operators.
Researchers plan to further customize their
designs to address filtration needs of specific
contaminants in certain rural communities, such
as naturally occurring arsenic.  The long-term
objective is to create versatile systems that can
be used by small communities anywhere in need
of reliable, low-cost, and low-maintenance water
purification systems.

Currently, the researchers have focused on
nearly 250 local Puerto Rico water systems that
are not under the regulation of the Puerto Rico
Aqueduct and Sewer Authority (PRASA). A third
of these non-PRASA systems either offer no
treatment or have treatment systems that are out
of order or not in use. Economical and technical
challenges, including a lack of electricity, make
it impossible to integrate traditional treatment
systems into these communities; this makes
the impact of EPA's research results critically
important.

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Sustainability Science: Understanding
Ecosystem Services in Wetlands
The multitudes of benefits people derive from
the environment are so abundant and free
flowing that they are easy to overlook. Because
these benefits are difficult to quantify, they are
often left out or undervalued in risk assessments
and other analyses that decision makers use to
set environmental policies and protect human
health.

EPA scientists have embarked on a research
effort to help change this oversight. Research
in Tampa Bay, Florida is advancing the science
of sustainability by focusing on aspects of the
natural environment that form the foundation of
ecology, economy, and overall well-being. These
beneficial aspects of nature are what scientists
refer to as "ecosystem services," and include
such things as flood control, fertile soils, biological
diversity, and the natural cycles that cleanse air
and water.

In 2012, EPA scientists completed a two-year

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 Page 42
The results of two-year study on wetlands and marshes near Tampa Bay, FL will become part of a dynamic model to understand how
human disturbance affects the ecosystem services of wetlands.
     study in nine mangrove wetlands and 18
     freshwater riparian and marsh sites with varying
     levels of human disturbance in the Tampa Bay
     drainage basin. Analysis of the study results will
     become part of a dynamic model that allows
     users to understand how human disturbance
     affects the ecosystem services of wetlands,
     particularly regarding the removal of nutrient
     pollution and improved water quality. This project
     is part of an effort to illustrate the trade-offs in
     ecosystem services associated with alternative
     management decision scenarios.  Research
     results are available through a new, user-friendly
     website for Tampa Bay.

     Additionally, scientists are partnering with local
     governments, other research entities, planning
     organizations, and citizen and business groups
     to identify and assess the values a  productive
     ecosystem provides to the community. All
     these experts will help paint a more complete
     picture of Tampa Bay that decision makers
     can use when establishing development and
     environmental plans.
A U.S. Human Well-being Index

A defining component of sustainability, as
highlighted in the National Environmental
Policy Act of 1969, is "to create and
maintain conditions under which humans
and nature can exist in productive
harmony, that permit fulfilling the social,
economic, and other requirements of
present and future generations."

EPA's Human Well-being Index (HWBI),
released as a draft in 2012, is being
designed to help communities live more
sustainably. When final, the HWBI will
provide a Web-based predictive model to
help communities better quantify the flow
of ecosystem services, and make decisions
that prioritize human well-being.

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                                                                                              Page 43

EPA's lakes web tool helps users understand the linkages between changing nutrient cycles and the delivery of important ecosystem
services to residents and visitors of the Northeast.
     Nutrient Tool for Lakes
     EPA researchers in Narragansett, Rhode Island,
     recently updated an important online resource
     that contains information on more than 28,000
     lakes in the northeastern United States. Scientists
     developed this Web tool to guide management
     decisions, particularly those that affect the flow
     of nutrients into the nation's lakes.

     Lakes provide valuable benefits—called
     ecosystem services—to residents and visitors
     and are increasingly important for maintaining
     recreational opportunities and amenities.
     However, northeastern population growth
     threatens regional lakes by, for instance,
     increasing levels of nutrients entering lake waters.

     EPA's updated Web tool helps users understand
     the linkages between changing nutrient cycles
     and the delivery of important ecosystem services
     to residents and visitors of the northeast.
The online lakes tool includes a Lakes Ecosystem
Services Database, which combines information
from a variety of sources such as EPA's National
Lakes Assessment and the U.S. Geological
Survey's SPARROW Model for water quality,
among other datasets. The tool also includes
a Geographic Information System (GIS) that
provides geospatial visualization, search, and
analysis  options.

Users can go online and query, sort, and
download data on lake location, depth, volume,
land cover, and surrounding human population.
They can also study the flow of nitrogen and
phosphorus into certain lakes, as well as explore
associations between those nutrients and the
benefits that people obtain from lakes. The tool is
intended to aid lake managers in the northeast
and nationwide to foster a better understanding
of the links between management decisions,
nutrients, and lake ecosystem services.

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The Tribal-Focused Environmental Risk and Sustainability
Tool is designed to provide tribes with the best available human
health and ecological scientific information.
                                                  Supporting Sustainable  and
                                                  Healthy Tribal and Native
                                                  Alaskan  Communities
The 565 federally recognized Tribal nations
across the United States manage more than
95 million acres of land. EPA's American Indian
Environmental Office works with those Tribes to
protect human health and the environment
by supporting and implementing federal
environmental and related human health
protection laws (as consistent with the Tribes'
sovereign rights, federal responsibilities, and
EPA's official Indian Policy).

That effort is supported by research exploring
ways to advance sustainable and healthy Tribal
communities. EPA scientists and the National
EPA-Tribal Science Council work collaboratively
to better understand environmental and human
health issues important to Native American and
Eskimo communities. (The EPA-Tribal Science
Council is composed of a tribal representative
from each of the nine Agency  regions across the
country.)

In 2012, EPA scientists and their partners
from tribes across the country continued to
develop and pilot a Web-based environmental
decision-support tool called the Tribal-Focused
Environmental Risk and Sustainability Tool (Tribal-
FERST). The tool is designed to provide tribes with
the best available human  health and ecological
scientific information.

Using stakeholder feedback from the National
Tribal Caucus,  numerous tribes, the consortium
of United South and Eastern Tribes (USET), Tribal
Colleges and Universities, and other stakeholders,
EPA researchers incorporated a host  of new
enhancements into the beta version  of Tribal-

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                                                                                          Page 45
FERST. These included additional tribal
information resources, enhanced maps
in a Geographic Information System
database with the ability to overlay
local data.

EPA researchers also collaborated with
the Pleasant Point Passamaquoddy
Tribe of eastern Maine to pilot Tribal-
FERST and address priority issues facing
the tribe, such as the need to consider
adaptive coastal management
strategies in the face of potential
sea level rise. The tribe also piloted
Tribal-FERST as a decision support
tool for comparing different waste
management options and outcomes,
including the production of power,
revenue, and jobs under various
scenarios.

Also in 2012, the EPA Tribal-FERST
team joined with the USET consortium
to develop a  tribal environmental
assessment roadmap and link Tribal-
FERST with the USET Tribal Water Quality
database and exchange node.

These ongoing partnerships, as well
as outreach at key tribal meetings
across the country, serve to enhance
Tribal-FERST and continue to connect
EPA science with tribal environmental
needs.
-
                                         EPA scientists and the National EPA-Tribal Science Council work
                                         collaboratively to better understand environmental and human health
                                         issues important to Native American and Eskimo communities.

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Page 46
    Protecting  Children's
    Health for  a Lifetime
    For more than 14 years, EPA has partnered with
    the National Institute of Environmental Health
    Sciences (NIEHS) to expand knowledge about
    children's environmental health through the
    EPA/NIEHS Children's Environmental Health and
    Disease Prevention Research Program. Together,
    they have invested more than $150 million to
    support a network of multidisciplinary Children's
    Environmental Health and Disease Prevention
    Research Centers (Children's Centers).

    Through the collaborative network, scientists,
    statisticians, pediatricians, epidemiologists, local
    community representatives, and other experts
    engage in cross-cutting research to understand
    and reduce children's health risks and promote
    health and well-being in the communities where
    they live, learn, and play.

    Children's Center researchers are investigating
    environmental, genetic, and epigenetic changes
    in gene expression based on nutrition and other
    factors) components of disease and disease
    prevention, as well as how social and cultural
    factors may be linked to many of today's most
    pressing children's health challenges, including
    asthma, autism, attention deficit hyperactivity
    disorder (ADHD), neurodevelopmental deficits,
    childhood leukemia, diabetes, and obesity.

    By design, a major emphasis of the Chidren
    Center's program is to effectively share research
    results with  health care professionals, educators,
    community groups, and parents in accessible,
    practical ways that will have real-world impacts
    in preventing disease and improving the health
    and development of children.
A sample of the many recent Children's Center
research findings over the past year include:

•  A study by researchers at the Center for
   Environmental Research and Children's
   Health at the University of California, Berkeley
   found an association between levels of the
   chemical  Bisphenol A (BPA) and lower levels
   of thyroid  hormones in pregnant women
   and newborn boys. Thyroid hormone during
   pregnancy and the neonatal period is critical
   to proper  development.

•  Researchers from the Dartmouth Children's
   Center suggest that rice and food containing
   organic brown rice syrup can expose children
   to arsenic, a known carcinogen that can
   also adversely affect neurologic, respiratory,
   hematologic, cardiovascular, gastrointestinal,
   and other systems.

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                                                                                            Page 47
•  Researchers at Columbia University's
   Center for Children's Environmental Health
   (CCCEH) found that children with exposures
   to phthalates (chemicals found in personal
   care and plastic products) have elevated
   risk of asthma-related airway inflammation.

•  CCCEH researchers were the first to find
   a difference between how boys and
   girls respond to prenatal exposure to the
   insecticide chlorpyrifos. They found that boys
   appear to be more vulnerable and lower
   IQs have been seen in boys exposed in the
   womb to this chemical.

•  A brain imaging study by CCCEH researchers
   found that even low to moderate levels
   of exposure to the insecticide chlorpyrifos
   during pregnancy may lead to long-term,
   potentially irreversible changes in the brain
   structure consistent with IQ deficits at age
   seven.

To learn more about EPA's Children's
Environmental Health and Disease Prevention
Research Centers, including how to sign up for
monthly EPA-sponsored webinars presenting the
latest research findings, please visit: www.epa.
aov/ncer/childrenscenters/.
                                                  EPA is part of a collaborative network of experts who engage
                                                  in cross-cutting research to understand and reduce children's
                                                  health risks and promote health and well-being in the
                                                  communities where they live, learn, and play.

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 Page 48
Visitor to the Smithsonian's National Zoo learns about EPA research and the importance of biodiversity.

    EPA, Smithsonian Biodiversity and Human
    Health Exhibit Opens
     EPA science has taken its place as a featured
     exhibit alongside giant pandas, bald eagles, and
     tigers at the Smithsonian Institution's National
     Zoological Park in Washington, DC.

     Working under a long-standing Memorandum
     of Understanding  between EPA and the
     Smithsonian to support partnerships between the
     two organizations, zoo exhibit developers and
     EPA scientists joined forces to produce a new,
     permanent interpretive exhibit highlighting the
     Agency's leadership role supporting biodiversity
     and human health research, and the importance
     of healthy ecosystems for the well being of
     humans.

     Opened in late 2012, the exhibit is housed in
     the zoo's Amazon/a Science Gallery. It features
a host of interpretive elements, including a
computer-based "tick counting game" that
invites children and other visitors to explore the
forest as environmental scientists do, a suite of
videos featuring EPA and partner field biologists,
and a host of education materials such as
posters, publications, and artifacts.

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                                                                                       Page 49
Chemical Safety  for Sustainability
Chemical safety is a major priority for EPA.
Achieving a safer and more sustainable future
requires developing new, innovative methods to
design, manufacture, use, and dispose of existing
and new chemicals in cleaner, less toxic ways.
With tens of thousands of chemicals currently in use
and hundreds more introduced every year, it also
demands faster, more efficient chemical testing
and screening methods.

EPA chemical research is focused on advancing
a better understanding of chemicals to maximize
safety and sustainability. Researchers are
developing fast, efficient, and less-costly ways to
collect and analyze data, better predict chemical
risk, and help reduce the current  backlog of
chemicals not fully assessed for potential human
health and environmental effects.

The data and studies EPA researchers generate are
publicly available through transparent, accessible,
online tools, providing the latest science-based
safety data  to support better, more informed
decisions protecting human health and the
environment.

This section highlights some of the top
research results in computational toxicology,
nanotechnology, sustainable chemical design,
pesticides, industrial chemicals, endocrine
disrupting chemicals, and human health risk EPA
researchers  and their partners achieved in 2012.
  Learn  More!
  For more information about the scope and impact of EPA research to support Chemical Safety
  Sustainability, please visit: www.epa.gov/research/chemicalscience/.

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EPA researchers are leading the development of innovative, new tools and toxicology screening and testing methods that are faster
and less costly than traditional practices.

     EPA's Computational Toxicology Research
     There are currently more than 80,000 chemicals
     listed or registered for use under EPA authorities,
     many of which have not been thoroughly
     assessed for the health and environmental
     risks. With hundreds more introduced into the
     marketplace every year, it's easy to see the
     enormous challenge facing EPA officials and
     others tasked with ensuring the sustainable
     production, use, and disposal of chemicals.

     To meet that challenge, EPA researchers are
     leading the development of innovative new
     tools and technologies to evaluate the safety of
chemicals, products, and emerging materials.
EPA computational toxicology researchers are
using advances in exposure science, molecular
and systems biology, chemistry, mathematical
and computer modeling, and computer
technology to predict chemical hazards and
risk. In the process, they are ushering in a new
generation of predictive tools to evaluate
potential chemical risk to human health and the
environment.

EPA's computational toxicology research
continued to make important strides in 2012.

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                                                                                          Page 51
Researchers analyzed automated, high-
throughput screening data and developed
high-throughput exposure predictions for
over 1,000 chemicals of interest. "High-
throughput" refers to the speed of chemical
tests (assays) or predictions, defined as
being capable of generating test results
or predictions for hundreds to thousands
of chemicals in just days or weeks. The
researchers also analyzed chemical
structures to identify which chemical
properties are  more likely to influence toxicity
and exposure potential.

These accomplishments promise to deliver
advanced methods that are not only higher
performing and faster, but also far less costly
to use.
                                                  Tox21
                                                  EPA researchers and their partners conduct
                                                  high-throughput chemical screening using
                                                  robotics and a variety of other technologies
                                                  available from a research  partnership called
                                                  Toxicity Testing in the 21st Century ("Tox21").
                                                  Tox21 is a collaborative federal research
                                                  partnership uniting EPA, the National Institutes
                                                  of Health, and the U.S. Food and Drug
                                                  Administration to screen tens of thousands of
                                                  chemicals.
                                                 The automated systems move small, specialized
                                                 test plates, each with 1,536 tiny wells of liquid
                                                 test solutions and containing human cells or
                                                 proteins, through a series of computerized
                                                 screening and analysis  activities, in effect
                                                 simultaneously running  thousands of separate
                                                 experiments at a time.

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EPA researchers are working to provide web-based tools that supply summary information based on extensive chemical exposure and
hazard data, decision-rules, and predictive models.
     Increasing Transparency and Accessibility of
     Chemical Safety Information
     EPA's computational toxicology research
     is building accessible, online databases on
     thousands of chemicals that can be shared
     with the public and those making policy
     and regulatory decisions about the safety of
     chemicals.

     As these extensive, Web-accessible databases
     are being developed, EPA is collaborating with
     academia and industry partners to gather the
     "critical mass" of chemical hazard and exposure
     data needed to advance innovation, and
     to launch the next generation of sustainable
     chemical design. By using the data to identify
the features of chemicals that contribute to their
hazardous properties, chemical engineers and
others will have the information they need to
design new functional, yet safer, chemicals.

The public release of computational toxicology
data provides opportunities to engage
stakeholders and to promote transparency
on how the data are used to inform EPA
decisions. It is also expected that by actively
engaging stakeholders and making research
results widely accessible, EPA will promote the
commercialization and use of the data and its
research, facilitating chemical safety assessments

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                                                                                        Pane 53
and the design of benign or less hazardous
materials by industry and others.

An additional result of this investment in
innovative science will be a reduction in the
number of animals needed for evaluating
chemical hazard and risk.

Chemical Evaluation Dashboards for
Decision Makers

For those protecting human health and the
environment by making decisions regarding
chemical risks and health effects, the extensive
databases and proliferation of additional
scientific information being generated by EPA's
CompTox and other research efforts can be
daunting.

To overcome this obstacle, EPA computational
toxicology researchers are developing
customizable and user-friendly Web-based
applications—called "Dashboards"—that
provide accessible, useful summary information
on chemical exposure and hazard data,
decision-tools, and predictive models. The
Dashboards compile information useful for
predicting risk and prioritizing chemicals for
further testing.

Prototype Dashboards were developed in
2012 for EPA's Endocrine Disruption Screening
program, to support chemical prioritization
for the Toxic Substances Control Act, and for
chemicals of concern for the Safe Water Drinking
Act's Candidate Contaminant List.

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ToxCast Partnership to Advance Chemical
Testing, Reduce Animal Testing
A major component of EPA's computational
toxicology research (see previous stories) is EPA's
toxicity forecaster, or "ToxCast." Researchers are
using ToxCast as part of work to systematically
screen chemicals to better understand the
potential impact exposures have on processes
in the human body that lead to adverse health
effects.

Using ToxCast, EPA screened more than 1,000
chemicals in some 700 fast, automated tests
called high throughput assays. Research results,
presented in a host of published scientific papers
in peer-reviewed journals, show ToxCast can be
used to predict a chemical's potential for liver
toxicity, developmental toxicity, reproductive
toxicity, and cancer.

Based largely on the promising results of ToxCast
for advancing computational toxicology
methods and for ushering in a new generation
of chemical screening methods that will be
faster, less costly, and greatly reduce the use
of laboratory animals, in March 2012, EPA and
the cosmetics company L'Oreal announced
a collaboration to expand the work to include
substances from the cosmetic sector.

As part of the partnership, L'Oreal is providing
EPA with $1.2 million in collaborative research
funding plus robust safety data from a set of
representative cosmetic substances. Substances
from L'Oreal are being assessed by ToxCast
and results will be compared to the safety data
L'Oreal provided.

For more than 30 years, L'Oreal has invested
in animal-free toxicology tests and the EPA

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                                                       '•• • •'
Using ToxCast, EPA researchers and their partners are screening more than 1,000 chemicals in some 700 fast, automated tests ,
including robot-assisted ones (pictured) to better understand their potential impact on processes in the human body that lead to
adverse health effects.
     collaboration will help the company to make
     predictions on the safety of substances earlier
     in the development process. It also expands
     the types of chemical use groups that EPA
     researchers are now assessing in ToxCast.

     The L'Oreal research partnership is just one
     of many that EPA researchers have fostered
     to increase the scope and impact of
     computational toxicology research efforts.
     One of the largest is the Toxicity Testing in the
     21st Century (Tox21) collaboration with the
     U.S. Food and Drug Administration and the
     National Institutes of Health, which pools federal
     resources and expertise to screen more than
     10,000 chemicals for potential toxicity (see EPA's
     Computational Toxicology Research).
EPA now has partners from more than 100
different organizations ranging from industry,
academia, trade associations, other federal
agencies, state governments, and non-
governmental organizations. Partners provide
a wide variety of support, including chemicals,
software, chemical toxicity study data and
results, different kinds of high-throughput
screening, and much more.

Partnerships are finalized through numerous types
of agreements. Individuals and organizations with
an interest in promoting the use of computational
toxicology and exposure science are invited to
participate in EPA's Computational Toxicology
Communities of Practice; for more information,
visit: http://1 .usa.aov/fevacF.

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                                                      4      i*.L
Ensuring  Safe Nanotechnology and Nanomaterials
Nanomaterials are materials between one and
100 nanometers in size (a nanometer is one
billionth of a meter). These tiny materials often
exhibit unique properties that are different from
those of the same substances in a larger size, and
have been tapped for manufacturing processes
and for applications in paint, cosmetics, treated
wood, electronics, and other products. While
nanomaterials offer important benefits, they may
also present some risks.

EPA is leading scientific efforts to understand the
potential risks to humans and the environment
from nanomaterials. This work includes:

•  Collaborating on Nano-copper: As part
   of the U.S. National Nanotechnology
   Initiative, EPA and the U.S. Consumer
  Product Safety Commission (CPSC) are
  collaborating in a worldwide effort to assess
  the effects of nanomaterials. Joint research
  includes exploring the potential human
  and environmental effects from exposure
  to copper nanomaterials used in wood
  treatment products for decks and fences.

• Children's Exposure: Another part of the EPA-
  CPSC collaboration focuses on the potential
  exposure  of children to nanoparticles. Of
  particular interest is nanosilver, which can
  prevent the growth of some bacteria or fungi
  and is sometimes used in the manufacturing
  of children's toys. Researchers are developing
  the tools,  approaches, and protocols
  needed to determine if nanosilver is released
  from children's products under real-world

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                                                                                        Page 57
   conditions. Preliminary study results on 13
   products indicate that the silver levels to
   which children may potentially be exposed
   during normal product use is low.

•  Nanosilver: To investigate potential health
   risks of nanosilverin everyday products
   such as body soap, laundry detergent, and
   toothpaste, scientists from EPA and the
   University of Nevada, Las Vegas, researched
   the changes that occur when nanosilver
   interacts with the acidic environment of a
   synthetic human stomach.

   Results showed that nanomaterials could
   alter the amount of silver that is absorbed
   by the body. Researchers further developed
   methods and standard test procedures for
   characterizing the physical and chemical
   properties that influence the health risks
   associated with nanosilver.

EPA researchers also released the document:
Nanomaterial Case Study: Nanoscale Silver in
Disinfectant Spray (see next column).
EPA Case Study: Nanosilver in
Disinfectant Spray

In 2012, EPA released Nanomateriai Case
Study: Nanoscaie Silver in Disinfectant
Spray.

The case study was conducted to support
research planning efforts for nanomaterials
such as the studies mentioned previously.
Researchers considered nanosilver in
disinfectant sprays across the entire
lifecycle of products, including how they
are produced, shipped, stored, used, and
disposed of or recycled. The report presents
information about how nanosilver materials
and waste by-products might move and
change before coming into contact with
people and other organisms, and the
potential impacts of exposures in these
populations.

For more information, and to download  a
copy of the report, see: http://1 .usa.gov/
WOo7vO.

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EPA research advancements in 2012 included narrowing down the field of already confirmed endocrine disrupting chemicals to
support targeted studies to identify specific mechanisms likely to cause harmful effects.

     Endocrine Disrupting  Chemical Research
     Normal growth and development, from
     conception, through pregnancy and to
     childhood and adolescence, depends on the
     intricate timing and release of hormones by
     the body's endocrine system, which regulates
     growth, maturation, and reproduction in people
     and animals.

     Scientists have discovered that exposures
     to excess hormones or to certain chemicals,
     known collectively as "endocrine disrupting
     chemicals," can disrupt the functioning of the
     endocrine system, which can lead to a series
     of development problems and other adverse
     effects, including cancer, diabetes, obesity,
     infertility, and childhood disorders.

     As  part of the effort to better protect human
     health and the environment, learning more
about endocrine disrupting chemicals and how
to screen and identify them from the thousands
of chemicals in use has been a high priority for
EPA researchers since the early 1990s.

In 2012, EPA scientists used innovative
approaches to assess thousands of chemicals
for potential endocrine disruption, and worked
with outside research partners to investigate the
effects of hormones in waste from concentrated
animal feeding operations.

Innovative approaches included an EPA-
developed Quantitative Structure Activity
Relationship (QSAR)-based estrogen expert
system, and the ToxCast approach (see previous
stories), to screen thousands of chemicals and
provide new information to EPA's Endocrine
Disruptor Screening Program (EDSP). The expert

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                                                                                        Page 5 9
system predicts the potential for chemicals
to bind to estrogen hormone receptors and
activate genes that cause health effects.

EPA researchers worked closely with the EDSP
to define the potential "chemical universe" of
endocrine disrupting chemicals that require
screening. In 2012, they identified more than
10,000 chemicals that make up this "chemical
universe," by identifying properties that could
cause them to interfere with natural hormones
and disrupt the endocrine system.

Advancements in 2012 included narrowing
down the field of already confirmed
endocrine disrupting chemicals to support
targeted studies and the identification of
specific chemical interactions with important
biological processes that are likely to cause
toxicological effects. The scientific information
is being used to help prioritize which
chemicals should be tested first by EPA, and
what additional tests are needed to assess the
chemicals.

Reducing Endocrine Disrupting
Chemicals in Chesapeake Bay

EPA scientists worked with the University of
Maryland Wye Research Center to determine
how to reduce the amounts of endocrine
disrupting hormones associated with
Concentrated Animal Feeding Operations
from reaching nearby waterways. Hormone-
containing wastes from these operations  can
get into soil and water, leading to adverse
effects such as intersex conditions in fish.

Research results from the collaboration
showed that tilling poultry fecal waste into
the soil and injecting the waste underground
reduced endocrine disrupting hormones
concentrations,  as compared to not tilling the
waste into the ground.

The findings will inform actions to reduce the
amount of poultry steroid hormones in storm
runoff coming from areas along Chesapeake
Bay.
                          PvT


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A series of EPA studies are providing key information to minimize exposure to PCBs in schools.
     PCB Research  Supports  Safer Schools
     In 2012, EPA researchers completed the first three
     of five studies they are conducting to answer
     questions about polvchlorinated biphenvls,
     (PCBs) in schools.  What they are learning is
     providing key information to minimize exposures
     and better protect students, teachers, and
     others.

     PCBs are a structurally similar group of manmade
     chemicals useful for a variety of applications.
     Some PCBs, for example, are slippery, making
     them valuable as industrial lubricants. Heat and
     flame resistant,  they were also used as insulators
     in transformers,  electrical appliances, and
     fluorescent light fixtures. PCBs were also used as
     stabilizers in paints, adhesives, and caulking.

     PCBs were widely used from 1950 until the
     late 1970s. Congress banned their use and
     manufacture in 1976 in the face of growing
evidence linking their exposure with adverse
human health effects, including cancer,
reproductive problems, and neurological
development.

While PCB exposures have been greatly reduced,
the combination of their previous widespread
use and persistence has meant they are still
present in the environment. Buildings, including
schools, built or renovated between 1950 and
1970 may contain PCBs, particularly in caulking or
fluorescent lighting fixtures.

In response to concerns raised by parents, EPA
scientists are identifying and evaluating potential
PCB sources in schools and advancing a better
understanding of how people might be exposed.
The researchers are also investigating methods to
minimize or eliminate PCB emissions in schools.

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In 2012, EPA researchers released the results
of three studies. The first two studies focused
on primary sources (such as caulk and lighting
fixtures) and secondary sources (paint, masonry
walls, and dust that can absorb PCBs from
primary sources) of PCBs in schools. The third
study investigated a containment method known
as "encapsulation" where PCB sources are
covered with a coating material to reduce air
and surface concentrations of PCBs.

Results of the studies include:
•  Encapsulation is only effective at reducing
   air concentrations to desirable levels when
   PCB content in the source is low. Selecting
   high-performance coating materials is key
   to effective encapsulation. Multiple layers of
   coatings enhance the performance of the
   encapsulation.

As EPA researchers gain new information they will
make further recommendations on how to best
prevent harmful PCB exposure in schools.
   Caulk put in place between 1950 and 1979
   may contain as much as 30% PCBs and can
   emit PCBs into the surrounding air. PCBs
   from caulk may also contaminate adjacent
   materials such as masonry or wood.

   Fluorescent lighting fixtures that still contain
   their original PCB-containing light ballasts
   have exceeded their designed lifespan, and
   the chance for rupture and emitting PCBs is
   significant. Sudden rupture of PCB-containing
   light ballasts may result in exposure to the
   occupants and may also result in the addition
   of significant clean-up costs.

   Some building materials (e.g., paint and
   masonry walls) and indoor dust can absorb
   PCB emissions and become potential
   secondary sources. When the primary PCB-
   emitting sources are removed, the secondary
   sources often emit PCBs.
                  Learn More about
                  EPA Chemical Safety
                  for Sustainability

                  For more information about
                  the scope and impact of
                  EPA Chemical Safety for
                  Sustainability research, visit:

                  • EPA Chemical Safety for
                    Sustainability: www.epa.gov/
                    research/chemicalscience/.
                  • EPA Computational
                    Toxicology Research: www.
                    epa.gov/comptox/
                  • Download a copy of
                    EPA's Chemical Safety
                    for Sustainability Strategic
                    Research Action Plan,
                    2012-2016: http://epa.gov/
                    research/docs/css-stra p.pdf

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EPA and research partners are exploring how to incorporate
the concepts of sustainability to advance the design of new,
innovative, "green " products made of safe substances and
manufactured with efficient, clean processes.
     Promoting  Chemical
     Sustainability
     There is no doubt that chemicals can make our
     lives easier. They are ubiquitous in our medicines,
     the cleaning and disinfection products we use
     to clean our homes and workplaces, and used
     throughout industry to make the many products
     we use and enjoy everyday. What would be
     even better would be to continue to enjoy these
     multiple benefits with minimal or no negative
     impacts to human  health and the environment.
Together with partners, EPA is exploring how
to incorporate the concepts of sustainability
to advance the design of new, innovative,
"green" products made of safer substances
and manufactured with more efficient, clean
processes.

In September 2012, EPA signed a Memorandum
of Understanding with the National Science
Foundation (NSF) to collaborate to help steer
more chemical research toward advancing
sustainability. In December, EPA and the National
Science Foundation released two requests
for applications (RFAs) to support innovative
research projects investigating ways to use
benign, more natural materials in developing
chemicals for use in everyday products.

The RFAs seek to fund innovative chemical
safety research focused on two distinct areas:
(1) sustainable, safe alternatives to existing
chemicals, and (2) assessments looking at the
entire life cycle of chemicals, from production to
disposal.

In addition to the partnership with NSF, EPA's
own scientists continued to advance chemical
sustainability throughout 2012. One example
is Greenscope, a six-year-effort that has
identified and ranked 139 separate indicators
of the chemical manufacturing processes on
a "sustainability scale" from 0 to 100 percent
sustainable.

In order to test Greenscope, researchers devised
a computer model of a hypothetical biodiesel
facility that included all the manufacturing
processes  and sustainability indicators. A
published case study on the model illustrated
how they were able to assess the sustainability
of the plant.  Also, in February 2012, EPA signed
an MOU with the company Procter and Gamble
to develop sustainability measures for its supply
chain management system, and possibly deploy
Greenscope at P&G facilities in the future.

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                                                                                     Page 63

   \
Human Health Risk Assessment
  EPA's Human Health Risk Assessment research
  program provides state-of-the-science products in
  support of risk assessment, such as independently
  peer-reviewed human health assessments for
  individual chemicals and chemical  mixtures;
  integrated science assessments and technical
  support to meet partner and stakeholder needs;
  and tools to modernize human health risk
  assessment.

  The research results and products of the
  program are used by local, state, national, and
  international authorities to guide waste site
  cleanups, protect the air, set exposure limits for
  chemicals in drinking water, and determine the
  potential risk to public health from exposures to
multiple environmental contaminants.

EPA researchers are helping to advance the
science of risk assessment through original
research, consultation with experts, and by
accepting new challenges. These include
developing community risk assessment tools and
tailoring risk assessments to inform key decisions.

This section highlights a few of the many
achievements from EPA's Human Health Risk
Assessment program from 2012. For more
information on the scope and impact of EPA
research on human health risk assessment, please
visit: http://www.epa.aov/ncea/.
  Learn More!
  For more information about the scope and impact of EPA research to support Human Health Risk

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                             IRIS is a human health risk assessment program through which Agency scientists
                             evaluate and present comprehensive risk information on the health effects that may
                             result from exposures to contaminants in land, water, and air.
Growing IRIS: Advancing EPA's Integrated Risk
Information  System
EPA researchers provide leadership to assess the
potential health effects posed by exposures to
chemicals in the environment. A critical part
of that effort is the Agency's Integrated Risk
Information  System, or "IRIS."

IRIS is a human  health assessment program
through which Agency scientists evaluate and
present comprehensive information on the
health effects that may result from exposures to
contaminants in land, water, and air.

IRIS health assessments provide information on
the hazards a chemical may pose as well as
information  on  "dose-response" (the relationships
between amounts of exposure and expected
effects), resulting in reference doses, reference
concentrations, cancer slope factors, and
inhalation unit risks. When combined with
information  about people's environmental
exposure to a chemical, IRIS assessments can be
used to characterize health risks.

IRIS assessments are not full risk assessments or
regulations,  but they provide part of the scientific
foundation that supports Agency decisions and
actions for the nation's environmental laws, and
are widely used throughout the country on the
federal, state, and local levels to guide cleanup
and other actions to protect human health.

Currently, IRIS contains information on more than
560 chemicals.
Over the past few years, EPA has taken steps
to significantly improve the IRIS program. Those
efforts continued throughout 2012.

On June 5, 2012, EPA publicly released an IRIS
progress report to the U.S. Congress (EPA's
Integrated Risk Information System Program,
Progress Report and Report to Congress, U.S.
Environmental Protection Agency). The report
provided Congress, stakeholders,  and the public
with an update on the program, and on EPA's
progress toward implementing recommendations
to improve the program made by the National
Research Council (NRC) in 2011.

Improvements were illustrated further with
the release of the 2012 draft assessments for
ammonia (IRIS Toxicological Review of Ammonia,
External Review Draft, U.S. Environmental
Protection  Agency) and several isomers of
trimethylbenzene (IRIS Toxicological Review of
Trimethylbenzenes, External Review Draft,. U.S.
Environmental Protection Agency).
The assessments present a new, highly
improved document structure which includes
a template for describing the literature search
approach  used in the assessments. In addition,
the documents clearly identify the strengths
and weaknesses of the analyzed studies and
explicitly describe how EPA guidance, methods,
and criteria were applied in developing the
assessments.

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Continuing the Agency's commitment to
improving the IRIS program, on May 16, 2012,
EPA announced that the NRC would conduct
a comprehensive review of the IRIS program's
assessment development processes, review
current methods for integrating data, and
recommend approaches for weighing
scientific evidence for chemical hazard
identification.

For more information on the IRIS program,
including opportunities to engage with EPA,
please visit the IRIS website (www.epa.gov/
IRIS/).
                                                    Strengthening IRIS

                                                    Because of the critical importance of IRIS in
                                                    supporting EPA and beyond, a strong, vital
                                                    and scientifically sound program is key to
                                                    providing needed health risk information.
                                                    Over the past two years, EPA has worked to
                                                    strengthen and streamline the IRIS program,
                                                    improving transparency and increasing
                                                    the number of final assessments added to
                                                    the IRIS database. Continually improving
                                                    IRIS is a priority for the Agency, and efforts
                                                    are underway to further strengthen and
                                                    streamline this important program.

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 Page 66
Confirming longstanding scientific understanding and research, the final assessment characterizes perc as a "likely
human carcinogen. "

     EPA's IRIS Program Releases Final Health
     Assessment for "Perc"
     In February 2012, EPA released the final health
     assessment for the chemical tetrachloroethylene,
     also known as perchloroethylene, or more
     commonly as "perc."

     Perc is a chemical solvent widely used in the
     dry cleaning industry and to manufacture some
     consumer products and other chemicals; it is also
     a common environmental contaminant.

     Confirming longstanding scientific understanding
     and research, the final assessment characterizes
     perc as a "likely human carcinogen." The
     assessment, which underwent rigorous,
     independent peer review, includes toxicity
     values for both cancer and non-cancer effects
     associated with exposure to perc over a lifetime.

     EPA has already taken several significant actions
     to reduce exposure to perc. For example, the
     Agency established  clean air standards for dry
     cleaners that use perc, including requirements
that dry cleaners operating in residential buildings
phase out its use by late 2020. EPA also set limits
for the amount of perc allowed in drinking water.

The toxicity values reported in the perc IRIS
assessment will be considered in future actions to
protect public health, such as:

•  Informing new Superfund clean up sites
   where vapor intrusion leads to indoor air
   contamination from perc,
•  Revising EPA's Maximum Contaminant Level
   for perc as  part of the carcinogenic volatile
   organic compounds group in drinking water,
   as described in the Agency's drinking water
   strategy, and
•  Evaluating the need for additional limits on
   the perc emissions into the atmosphere; (perc
   is listed as a hazardous air pollutant under the
   Clean Air Act).

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                                                                                           Page 67
                           CAUTION
                   HAZARDOUS WASTE SITE
                    DIOXIN CONTAMINATION
                      * STAY IN YOUR CAR
                      * MINIMIZE TRAVEL
                      * KEEP WINDOWS CLOSED •
                      • STAY ON PAVEMENT        r'"
                      • DRIVE  SLOWLY
As a result of efforts by EPA, state governments and industry,
known and measurable air emissions ofdioxins in the United
States have been reduced by 90 percent since 1987.

     Final Non-Cancer Science
     Assessment for Dioxins
     Released
     On February 17, 2012, EPA reached a major
     milestone by completing its non-cancer health
     assessment for dioxin. Dioxins are toxic chemicals
     that exist naturally and can be released to the
     environment through forest fires, backyard burning
     of trash, certain industrial activities, and residue
     from past commercial burning of waste.

     Over the past two decades EPA has worked to
     significantly reduce emissions from all of the major
     industrial sources of dioxins. Today, the largest
     remaining source of dioxin  emissions is backyard
     burning of household trash.

     EPA's final report, Reanalysis of Key Issues Related
     to Dioxin Toxicity and Response to MAS Comments,
     Volume 1 (Dioxin Reanalysis), describes the health
     effects (other than cancer) that may result from
     exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
     (TCDD), the most toxic of the many different forms
     of dioxin (also known as congeners).

     The assessment also establishes, for the first time,
     a non-cancer oral reference dose (RfD) that
     represents the amount of dioxin a person can
be exposed to every day over a lifetime that
is not likely to cause harmful effects. Scientists
can use this RfD to calculate the toxicity of the
many other dioxin congeners relative to TCDD.
This provides a way to add up the toxicity of all
dioxin congeners that appear together in an
environmental mixture.

Most Americans  have low-level exposure to
dioxins. The health effects associated with
dioxins depend on several factors, including:
how much dioxin a person is exposed to, when
someone was exposed, and for how long and
how often someone is exposed. Based on data
from animal and human epidemiology studies,
there is concern  that exposure to low levels
of dioxins over long periods (or exposures at
sensitive times during the lifespan) might result
in reproductive or developmental effects and
other health effects.

The non-cancer  health assessment for dioxin
is a significant achievement for EPA  and
will contribute to the Agency's mission of
protecting public health. The information in the
assessment will be considered in a variety of
Agency activities, such as establishing cleanup
levels at Superfund sites, reviewing the drinking
water standard for dioxin, and evaluating
whether additional Clean Air Act limits on dioxin
emissions are warranted.
     2,3,7,2

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Page 68
   Integrated Science Assessments:  Gathering the Best Air
   Science to Protect Human Health and the Environment
   EPA sets National Ambient Air Quality Standards
   (NAAQS) for six "criteria" air pollutants—ozone,
   particulate matter, carbon monoxide, sulfur
   dioxides, nitrogen oxides, and lead—considered
   harmful to human health and the environment.

   Interdisciplinary teams of EPA scientists prepare
the Integrated Science Assessments (ISAs)
that review, synthesize, and evaluate the most
policy-relevant science to serve as a scientific
foundation for the review of NAAQS. The ISAs
synthesize relevant information from a large body
of literature, generally encompassing thousands
of studies, from across scientific disciplines

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including atmospheric chemistry, exposure
science, epidemiology, animal and human
toxicology, and terrestrial and aquatic ecology.

All ISAs are vetted through a rigorous scientific
peer review process, which includes two reviews
by the Clean Air Scientific Advisory Council,
and are made available for public review and
comment.
documents to help evaluate the impacts of
ambient air pollution mixtures on health and
climate. The multipollutant assessments are
expected to help EPA scientists and managers
better understand uncertainties about the effects
of pollutants within the air pollution mixture. The
multipollutant assessment work will also stimulate
additional research and data gathering activities
to benefit future assessments.
During 2012, EPA scientists continued to make
significant progress in developing ISAs. In
February, the Agency released the second
external review draft of the ISA for lead for
public review and comment, and in November
released the third draft of the lead ISA. In June,
EPA released the third external review draft of
the ISA for ozone and related photochemical
oxidants for public review and comment.

EPA also held a  "kickoff" workshop to initiate
the next review of the health-based NAAQS
for nitrogen oxides, in keeping with the Clean
Air Act requirement for periodic reviews of the
standards.

In addition, EPA  scientists are laying the
groundwork for incorporating multipollutant
analyses into their assessments. The Agency
is currently developing multipollutant science
Integrated Science Assessments Released in
2012:

Lead
•  November 2012: EPA released the third
   external review draft of the ISA for Lead for
   public review and comment. [Federal Register
   Nov27. 2012]
•  February 2012: EPA released the second
   external review draft of the ISA for Lead for
   public review and comment. [Federal Register
   Feb2, 20121

Ozone
•  June 2012: EPA released the third external
   review draft of the Integrated Science
   Assessment of Ozone and related
   Photochemical Oxidants (EPA/600/R-10/076C)
   for public review and comment. [Federal
   Register Jun 19,2012]

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                                     *•<•

               V
              I >

                        *ut*f- ' •
EPA's draft assessment concludes that current ambient air concentrations of asbestos In the Libby, Montana mine area did not appear
to cause levels of risk above EPA Superfund targets.

     Asbestos Toxicity Estimates to Help  Protect
     Health in Libby, Montana
     In 2009, EPA Administrator Lisa P. Jackson
     declared a public health emergency in Libby,
     Montana. This unprecedented action by an EPA
     Administrator recognized serious health risks,
     including lung cancer, mesothelioma, asbestosis,
     and decreased lung function, posed from
     exposure to Libby Amphibole asbestos present in
     the community from past mining and  vermiculate
     processing.
EPA started cleanup activities for the
contaminated former Libby mine in 1999, and
the area was listed as a Superfund site in 2002.
Throughout that time, Agency researchers have
worked closely with partners from EPA's Region
8 Office (serving Montana, Colorado, North
Dakota, South Dakota, Utah, and Wyoming) and
the local community to support those efforts and
better protect public health.

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In 2011, EPA released the IRIS Toxicological
Review of Libby Amphibole (External Review
Draft). This health assessment, when final, will
support cleanup and related risk management
initiatives at the Libby Superfund site.

The draft assessment presents conclusions
about potential human health hazards for
cancer and non-cancer health effects, and it
provides toxicity values that will be used to help
characterize risk in areas where people may be
exposed to Libby Amphibole asbestos.

The draft assessment has undergone rigorous
peer review and incorporates a transparent
process including ample opportunity for
community and stakeholder involvement and
public comment. An explicit part of the process
was to engage the affected community in the
review process. Those efforts continued well into
2012.

In February of 2012, EPA's Scientific Advisory
Board (SAB) held a public peer review meeting
on the draft Libby Amphibole asbestos
assessment and held two public teleconferences
of the SAB Libby Amphibole Asbestos Panel in
May to discuss the Panel's report on its review of
the draft assessment.

EPA scientists will consider public and peer review
comments as they finalize the assessment. The
final assessment will help the Agency secure
the best path forward for cleaning up Libby
Amphibole asbestos and for protecting public
health at the Libby Superfund site.
Learn More about EPA's Human Health Risk Assessment Research

For more information about the scope and impact of EPA Human Health Risk Assessment
research, visit:

•  EPA Human Health Risk Assessment Research: www.epa.gov/nceawwwl/hhra/index.htm.
•  EPA Integrated Risk Information System (IRIS): http://www.epa.gov/iris/
•  Download a copy of EPA's Human Health Risk Assessment Strategic Research Action Plan,
   2012-2016: http://epa.gov/research/docs/hhra-strap.pdf

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                                                                           rak %f
Page 72
                                                                                 "« J


  Supporting and Building Partnerships
    EPA supports the nation's leading scientists
    and engineers to facilitate the pursuit and
    dissemination of high-quality research to build
    a strong foundation for Agency actions and
    decisions. Additionally, EPA researchers cultivate
    and maintain partnerships with research
    colleagues at colleges and universities around
    the world, at partner federal and state human
    health and environmental agencies, and other
    entities throughout the scientific community.

    The Agency's extramural research program funds
    research grants, graduate and undergraduate
    fellowships, and large research centers through
    a competitive solicitation processes and
    independent peer review. These programs
engage the nation's best scientists and engineers
in targeted research that complements EPA's
own research.

EPA is also one of 11 federal agencies that
participate in the Small Business Innovation
Research (SBIR) program, established in 1982 to
strengthen the role of small business in federal
research and development, to create jobs,
and to promote technical innovation. EPA's
SBIR program awards funds to innovative small
businesses that have novel concepts for products
and technologies that will help spur economic
growth while advancing a more sustainable
future.
    Learn More!
    For more information on EPA research grants, fellowships, and awards,

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                                                                                   Page 73
EPA Research Grants and Fellowships for 2012
EPA funds research grants and graduate
fellowships in numerous environmental science
and engineering disciplines through its Science
to Achieve Results (STAR) program. The
program engages the nation's best scientists
and engineers in targeted research that
complements EPA's own intramural research
program and supports partners in other federal
agencies.

The Agency awarded 126 Fellowships (87
graduate and 39 undergraduate),  114 grants
(this includes funds awarded in Fiscal Year 2012,
which includes late 2011), and 32 Small Business
Innovation Research (SBIR) awards to support
environmental research conducted in 2012.

Grants are given through competitive solicitation
processes followed by independent peer review.

In addition, through this same competitive
process, EPA periodically establishes large
research centers in specific areas of national
concern. Currently, centers focus on children's
environmental health, nanotechnology, clean
air, computational toxicology, health effects
of pollutants, and green infrastructure and
stormwater management for Chesapeake Bay.

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STAR Graduate Fellowships

The STAR Graduate Fellowship Program supports
masters and doctoral candidates working
towards advanced degrees and careers
in environmental science and engineering.
Students can pursue degrees in traditionally
recognized environmental disciplines as well as
other fields such as environmental anthropology,
urban and regional planning, and decision
sciences.

STAR fellowships are intended to help defray the
ever-increasing costs associated with studies
leading to advanced degrees in environmental
sciences. Eighty-seven STAR Graduate Fellowships
were awarded to support graduate work in
human health and environmental research in
2012.
Greater Research Opportunities (GRO)
Fellowships

The Greater Research Opportunities (GRO)
fellowships support undergraduate students in
environmental fields of study. The goals of the
program are to bolster the next generation of
environmental leaders, inspire and train diverse
communities, and boost excellent research and
development.

Eligible students receive support for their junior
and senior years of undergraduate study and for
an internship at an EPA facility during the summer
between their junior and senior years. The
fellowship provides up to $20,700 for academic
support and up to $8,600 of support for a three-
month summer internship. The Agency awards
approximately 40 new fellowships each year.

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STAR Grants to  Support Air Quality Measurement
Technology and  Management
EPA awarded four grants totaling approximately
$1.25 million to develop and demonstrate new
air quality measurement technology.

The supported research will allow measurements
of pollutants and the creation of smaller
measurement devices for addressing emerging
air pollution issues and improving air pollution
measurement and data collection.
Additionally, five projects were supported with
$2 million to create the scientific foundation for
improving the air quality management system.
These projects will increase the rate at which
new information is incorporated into regional
and local air quality management and develop
techniques for improved air quality.
 Summary of Air Quality Measurement Technology Grants
Recipients
Washington University
University of
California-San Diego
Princeton University
University of
Wisconsin-Madison

Research Project
Development of Cost-effective, Compact Electrical
Ultrafine Particle (eUFP) Sizers and Wireless eUSF
Sensor Network
A compact, low-cost, network accessible, optical
particle counter for the real time measurement of
submicron aerosol particle size distributions
Compact Multi-Pollutant Mid-Infrared Laser
Spectroscopic Trace-Gas Sensor
Assessing the Synergistic Impact of Anthropogenic
and Biogenic Emissions on Air Pollution Using Novel
High-Sensitivity, Real-Time Monitors for Fundamental
Carbonyls

Amount Awarded
$499,000
$250,000
$250,000
$250,00000
Total: $1.25M

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Summary of Air Quality Management Grants
Recipients
University of Texas-Austin;
Massachusetts Institute of
Technology
University of North Carolina-
Chapel Hill; Pennsylvania State
University-Main Campus
Georgia Institute of Technology,
Georgia Environmental
Protection Division, Georgia
Forestry Commission
Texas A&M University-Kingsville
SUNY-Albany, SUNY College
of Environmental Science and
Forestry

Research Project
Analysis of Dynamic, Flexible NOx and SO2
Abatement from Power Plants in the Eastern
U.S. and Texas
Dynamic Electricity Generation for
Addressing Daily Air Quality Exceedances in
the US
Dynamic Management of Prescribed
Burning for Better Air Quality
Optimization of Multipollutant Air Quality
Management Strategies
Creating Building Blocks fora More Dynamic
Air Quality Management Framework

Amount Awarded
$500,000
$250,000
$500,000
$249,115
$499,945
Total: $2.0M

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The frequency of extreme events such as large storms and severe droughts, is expected to increase with continued climate change.

     STAR Grants to Support Research on the Impacts of
     Global Climate Change
    EPA awarded 14 grants, totaling more than $8
    million, to support research exploring ways to
    provide the information and tools needed for
    effective air and water quality management
    during anticipated increases in extreme events
    such as large storms and severe droughts.

    The Agency-supported research focuses
    on understanding the hazards of extreme
    events, and to establish ways for experts and
stakeholders, such as climate scientists, impact
assessment modelers, and air and water quality
managers, to address water and air quality
challenges and increase community resiliency in
the face of extreme weather events and natural
disasters.

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Summary of STAR Grants for Extreme Event Impacts on Air Quality
and Water Quality with a Changing Global Climate
Recipients
Oregon State University



Georgia Institute of Technology -
Main Campus

Massachusetts Institute of
Technology, Colorado State
University, North Carolina State
University

University of South Florida

Michigan Technological
University, University of Louisville

University of Texas at Austin

Mississippi State University



Public Policy Institute of
California, Climate Central



Cornell University, National
Center for Atmospheric Research
Ohio State University - Main
Campus


University of South Florida


Research Project
Prediction and quantification of Combined
Sewer Outflows under extreme storm events:
Flow dynamics and Reduction of Combined
Sewer Outflows
Air Qualitv Impacts of Extreme Weather
Events: Historical Analysis and Future
Projection
Usina Advanced Statistical Techniques
to Identify the Drivers and Occurrence of
Historical and Future Extreme Air Quality
Events in the United States from Observations
and Models
Early Career: The hazards of Extreme
Climatic Events: Predictina Impacts
Impacts of Climate-induced Chanaes in
Extreme Events on Ozone and Particulate
Matter Air Qualitv
Response of Reaional Air Quality to Severe
Drought
Role of land use and BMPs in reducina the
effect of extreme maanitude events on
sediment and pollutant transport in the SE US
Coastal Plain and Mississippi Alluvial Valley
Intearatina Information from Climate
Scientists and Resource Manaaers: Informina
Preparedness and Adaptation to Extreme
Event Impacts on Air and Water Qualitv in
California
Extreme Air Quality Events Usina a Hierarchy
of Models: Present and Future
Ensurina Safe Drinkina Water in Lake Erie:
Quantifyina Extreme Weather Impacts on
Cvanobacteria and Disinfection Byproducts

Ecoloaical Assessment of Generalized Littoral
Environments Decision-Support System
fEAGLE/OS)
Award Amount
$265,528



$749,859


$749,931




$374,936

$374,960


$750,000

$363,258



$710,529




$746,825





$734,122



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Summary of STAR Grants for Extreme Event Impacts on Air Quality
and Water Quality with a Changing Global Climate, continued
Recipients
University of Washington
Michigan State University
Columbia University in the City of
New York

Research Project
Prediction of Effects of Changing
Precipitation Extremes on Urban Water
Quality
Forecastina and Evaluatina Vulnerability of
Watersheds to Climate Chanae, Extreme
Events, and Algal Blooms
Combinina Empirical Orthoaonal Function
and Extreme Value Theory Methods to
Characterize Observed and Future Chanaes
in Extreme U.S. Air Pollution Events

Award Amount
$699,905
$750,000
$749,951
Total: $8,0 19,534

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STAR Grants to Support Chesapeake Bay
EPA awarded the University of Maryland a grant
totaling $691,674 for supporting a research
center to identify new, collaborative approaches
to reduce urban stormwater from reaching
Chesapeake Bay.

The center's research includes: applying existing
stormwater-reduction techniques in new ways;
developing new techniques and technologies;
identifying why existing Chesapeake Bay
restoration or protection strategies have
succeeded or failed; developing methods
and metrics to document water-quality
improvements in Chesapeake Bay tributaries;
and developing strategies for specific sectors
(residential, industrial, commercial developments,
transportation infrastructure) in the Chesapeake
Bay watershed to contribute to a cleaner Bay.

The University of Maryland research will
complement similar EPA-supported work
conducted by Pennsylvania State University
researchers to understand how decisions are
made at multiple levels to improve the planning,
design, adoption, and successful implementation
of innovative, sustainable stormwater
management systems to protect and restore
Chesapeake Bay. EPA awarded Pennsylvania
State University a grant of $2,173,026 in 2011  to
support that research. (Also see Community-
Based Chesapeake Bay Stormwater
Management on page 30.)
Summary of Grants to Support Water and Watersheds, Pollution Prevention, and
Sustainable Development for Chesapeake Bay
Recipients
University of Maryland - College
Park
Pennsylvania State University

Research Project
Sustainable Community Oriented
Stormwater Manaaement: A Sensible
Strateav for the Chesapeake Bav
Center for Green Infrastructure and
Stormwater Manaaement (awarded in mid
20111

Amount
Awarded
$691,674
$2,173,026
Total: $2,864,700

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Oil from the Deepwater Horizon oil spill coats the water's surface, June 2010.
    STAR Grants to Support the Environmental Impact and
    Mitigation of Oil  Spills
    EPA awarded four grants totaling $1.9 million to
    explore the development of innovative oil spill
    mitigation technologies and to provide needed
    technical assistance to Gulf Coast communities
    impacted by the Deepwater Horizon oil spill.

    The funding will enable Gulf Coast communities
    affected by the oil spill to effectively participate
    in research projects so that they can benefit
    from, and use, the results in restoration
and cleanup activities. The EPA-supported
research will develop cost-effective, innovative
technologies with low environmental impact that
can be used for mitigating the impacts of oil spills,
including: oil dispersants, surface washing agents,
and bioremediation agents; also supported are
projects investigating the environmental effects
of oil spills and the application of dispersants and
other clean up measures.
    Summary of Grants for studying the Environmental Impact and Mitigation of Oil Spills
Recipients
Michigan State University,
Louisiana State University-Baton
Rouge
Clemson University, University of
South Alabama
Iowa State University, Columbia
University in the City of New York,
Louisiana State University-Baton
Rouge
Skidaway Institute of
Oceanography, University of
Maryland, University of Southern
Mississippi

Research Project
Environmental Impact and Mitigation of Oil
Spills
Dendritic Polymers as Biocompatible
Dispersants for Oil Spill Remediation
Producing and Characterizing Bacillus
Subtilis Biosurfactants with Potentially
Lower Environmental Impact for Salt Water
Applications
Uptake and Effects of Dispersed Oil Droplets
and Emulsified Oil by Estuarine Crustaceans
in the Gulf of Mexico

Amount
Awarded
$500,000
$500,000
$500,000
$476,553
Total: $ 1,976,553

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Pare 82

                                           STAR Grants to Support
                                           Treatment Technologies
                                           for  Small Drinking Water
                                           EPA awarded 11 grants totaling $5.5 million
                                           to support research on and demonstration
                                           of new and existing drinking water treatment
                                           technologies in small, public water systems to
                                           reduce or eliminate chemical contamination.

                                           The research aims to provide small systems with
                                           reliable and more cost-effective treatment
                                           technologies to better manage co-occurring
                                           chemicals or groups of chemical contaminants
                                           in their water systems, resulting in cleaner water
                                           and a reduction in waterborne illnesses.
   Summary of EPA Grants Research and Demonstration of Innovative Drinking Water
   Treatment Technologies in Small Systems
Recipients
University of Massachusetts,
Amherst
Lincoln University-MO, University of
Missouri- Columbia
University of Illinois at Urbana-
Champaign
University of Texas - Austin
University of Nevada - Reno
Arizona State University, Main
Campus; University of Alaska,
Anchorage
The City College of New York
Research Project
Use of Ferrate in Small Drinkina Water
Treatment Systems
Improvina Drinkina Water Qualitv for Small
Rural Communities in Missouri
Sustainable Catalytic Treatment of Waste
Ion Exchanae Brines for Reuse Durina
Oxvanion Treatment in Drinkina Water
Fluoride, DBF Precursors, and Particles:
Simultaneous Removal with Aluminum Salts
A Solution for Small Drinkina Water Systems
Contaminant Removal Usina Membrane
Distillation for Sustainable Drinkina Water
Treatment
Sustainable Sorbents and Monitorina
Technoloaies for Small GroundwaterSvstems

Municipal Sewaae Sludae Based Composite
Adsorbents For Removal Of Contaminants
from Drinkina Water Sources
Award Amount
$497,078
$499,996
$500,000
$499,357
$499,743
$500,000
$499,746

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Summary of EPA Grants Research and Demonstration of Innovative Drinking Water
Treatment Technologies in Small Systems, continued
Recipients
University of Texas at El Paso, New
Mexico State University - Main
Campus
Clarkson University, Southern
Nevada Water Authority
University of Florida, University of
South Florida
University of Iowa, Johns Hopkins
University, University of California -
Riverside,

Research Project
Point Of Use (POU) Water Treatment
Systems For Improvina Sustainabilitv And
Environmental Justice in Colonias of the
Paso del Norte Reaion
Intearation of Filtration and Advanced
Oxidation: Development of a Membrane
Liauid-Phase Plasma Reactor
Small, Safe, Sustainable (S3) Public Water
Systems throuah Innovative Ion Exchanae
Research and Demonstration of Electrospun
Nanofiber Filters: Multifunctional, Chemically
Active Filtration Technoloaies for Small-Scale
Water Treatment Systems

Award Amount
$498,906
$499,779
$499,361
$499,466
Total: $5,493,432

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STAR Grants to Support Computational Toxicology
EPA awarded eight grants totaling nearly $8.6
million to support research to develop new,
innovative ways to test and screen chemicals
and chemical mixtures.

In support of EPA's commitment for safe and
sustainable chemicals, the Agency is supporting
the development of computational toxicology
methods (high-throughput assays; see more in
the "Chemical Safety forSustainability" section of
this document). The supported work is advancing
insight into the causal relationship between
chemical exposures and adverse developmental
and reproduction health effects.
Summary of Grants for Developing High-Throughput Assays for Predictive Modeling of
Reproductive and Developmental Toxicity Modulated Through the Endocrine System
or Pertinent Pathways in Humans and Species Relevant to Ecological Risk Assessment
Recipients
University of Texas-Austin
Batelle Memorial Institute, Pacific
Northwest Division
University of California-Davis
University of Michigan-Ann Arbor
North Carolina State University
University of North Carolina-
Chapel Hill
Oregon State University
University of South Carolina at
Columbia

Research Project
High Information Content Toxicity Screening
Using Mouse and Human Stem Cell Models
of Endocrine Development and Function
High-Throughput Cellular Assays for
Modeling Toxicity in the Fish Reproductive
System
In Vitro to In Vivo Screening of Thyroid
Hormone Receptor Disrupting Chemicals
Cell-Free Neurochemical Screening Assays
to Predict Adverse Effects in Mammals, Fish,
and Birds
Multi-Sensor Reporter Cell Technology to
Assess Hazard Involving Endocrine Signaling
Pathways
Carolina Center for Computational
Toxicology: Assays, models and tools for
NextGen safety assessments
Toxicity Screening with Zebra fish Assay
Imaging Assessment of G-protein-coupled
Estrogen Receptor Activation

Award Amount
$1,200,000
$1,199,908
$649,345
$1,199,222
$950,507
$1,200,000
$1,199,999
$1,063,460
Total: $8,662,441

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Collaborating on Health Disparities  Research
EPA is a partner in the Federal Collaboration
on Health Disparities Research, a coordinated,
federal effort to target health improvement
in populations disproportionately affected by
disease, injury, and/or disability. The collaboration
pools scientific expertise and resources to
advance the research needed to accelerate
the elimination of health disparities in vulnerable
populations.

Additionally, EPA is partnering with the National
Institute on Minority Health and Health Disparities
(NIMHD), a division of the National Institutes
of Health. This partnership supports health
disparities research that takes into account the
complex interaction of biological, social, and
environmental factors that influence the health
of certain populations. EPA and NIMHD recently
funded 10 grant awards to support research
initiatives and activities within NIMHD Centers of
Excellence program.
Institution
University of New Mexico Health
Sciences Center
Weill Cornell Medical College, Cornell
University
Georgia State University
University of Kansas Medical Center
Columbia University Medical Center
The University of Texas at El Paso, The
University of Texas Health Science
Center Houston
University of Illinois at Chicago
Meharry Medical College, Charles
Drew University of Medicine &
Science, National Space Science
and Technology Center, Tulane
University of Louisiana, University of
Maryland - Baltimore, University of
Tennessee - Knoxville
University of South Carolina at
Columbia, University of Maryland
University of Michigan - Ann Arbor,
Drexel University, Jackson State
University

Project Titles
New Mexico Center for Advancement
of Research, Enaaaement, & Science
on Health Disparities (NM CARES HD) -
Environmental Health Core
Environmental Health Disparities Research
Core
Center of Excellence: Environmental
Health Disparities Core
Central Plains Center for American Indian
Health Disparities (CPC-AIHD) Revision
Environmental Health Disparities Research
in NOCEMHD
Revision Application to Support
Environmental Health Disparities Research

Improving Environmental Health
Disparities: A Fundamental Cause
Approach
Environmental Context of Health
Disparities
Analysis and Action on the Environmental
Determinants of Health and Health
Disparities
Center for Intearative Approaches
to Health Disparities - Environment
Assessment Core

Award Amount
$792,750
$860,901
$724,523
$791,461
$850,638
$752,795
$817,064
$684,465
$669,258
$556,144
Total: $7,499,999

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Stoking the Economic Engine: EPA's Small Business
Innovation Research Awards
There are approximately 25 million small
businesses in the United States today. As the
leading source of employment growth, these
firms have generated 60 to 80 percent of new
jobs over the past decade, and are responsible
for developing most of the country's new
technologies.

EPA is helping to stoke the economic engine
and tap the entrepreneurial energy of small
businesses to meet today's environmental
challenges while also growing a green and
sustainable economy.

EPA's Small Business Innovation Research (SBIR)
program was established to ensure that new
technologies are developed to solve priority
environmental problems. In 2012 EPA awarded
nearly $4.1 million to 32 small companies to
support the development of new technologies
for protecting the environment and public
health.

Twenty-five small businesses received "proof
of concept" awards up to $80, 000 (phase I
recipients). In addition, seven companies that
received similar awards in 2011 were awarded
additional 2012 funding, up to $300,000, to move
their technologies towards commercialization
and implementation (phase II recipients).

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Summary of EPA Phase I SBIR Awardees
Small Business
Aerodyne
Research Inc.
Luna Innovations
Inc.
OnTo Technology
LLC
Fungi Perfect! LLC
Orono Spectral
Solutions Inc
GVD Corporation
ThornProducts
LLC
LIES Inc.
SolarBee Inc.
Fluidic
microControls, Inc
Faraday
Technology Inc.
Sunocs LLC
Los Gatos
Research Inc.
NEI Corporation
Compact
Membrane
Systems Inc.
Intelligent Optical
Systems Inc.
T3 Scientific LLC
Altex
Technologies
Corporation
NanoSonic Inc.
Okeanos
Technologies LLC
Project Titles
Size-Selection Aerosol Characterization Instrument

Non-Formaldehvde Bio-based Phenolic Resins

Recvclina Rare Earth Metals from Nickel Metal Hvdride
Batteries
Comprehensive Assessment of Mycofiltration Biotechnoloay to
Remove Pathoaens from Urban Storm Water
Preconcentration Technoloav for Infrared Analysis of
Organophosphates in Water
Environmentallv-Benian Polvtetrafluoroethvlene (PTEE) Coatina
for Mold Release
New Technoloay for Electricity Monitorina & Reportina Built
into Electrical Receptacles and Switches
Real-Time, In-Line Sensor for Wastewater Monitorina
Improvina TTHM Reduction Processina and Operational
Efficiencies in Potable Water Distributions Systems Usina Solar-
Powered Circulation with Diffused, Near-Surface Aeration
A 10 Kilowatt, Rankine Cycle Aaricultural Waste to Enerav
Conversion Module Utilizina Ultra Micro Turbo-Alternators
Microelectrode Arrav to Enable Robust Water Monitorina for
Multiple Contaminants at Sub-Nanomolar Concentrations
A Non-Toxic Composite Flame Retardant
Ultra-Sensitive Detection of Air Toxics Usina Incoherent Cavitv
Ringdown Spectroscopy
Siloxane Removal from Bioaass Usina a Novel Drop-In
Technology
Enhanced Drvina of Pipeline Ethanol

Fiber Optic Distributed Chemical Sensors for Environmental
Impact Monitorina in Carbon Seauestration
Forward Osmosis Water Purification Membranes for Small
Operations
Hiahlv Efficient Water Manaaement System for Lianocellulosic
Biomass
VOC-free, Hiahlv Flame Resistant HvbridSil™ Insulation
Coatinas for Next Generation Thermal Insulation and Eneray
Efficiency
Cost Effective Seawater Desalination with ICP Element Arrays

Award Amount
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000
$80,000

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Summary of EPA Phase I SBIR Awardees, continued
Small Business
Synanomet LLC
Adherent
Technologies Inc.
The Laser Sensing
Company
Electron Energy
Corporation
Membrane
Technology and
Research Inc.
Project Titles
Novel Lianin-Based Maanetite Nanocomposites for Removal
of Phosphate from Contaminated Waters
Emission Control System for Small Boilers

lnFRNO2: INfrared Faradav Rotation of NO2 for Portable Sub-
Part-Per-Billion Sensors
Cost-Effective Rare Earth Element Recyclina Process from
Industrial Scrap and Discarded Electronic Products to
Valuable Maanetic Alloys and Permanent Maanets
Membrane Process for Solvent Reclamation and Reuse

Award Amount
$80,000
$80,000
$80,000
$80,000
$80,000
Summary of EPA Phase II SBIR Awardees
Small Business
OPTRA Inc.
FBS Inc.
Adherent
Technologies Inc.
Advanced
Diamond
Technologies Inc.
Faraday
Technology, Inc.
TDA Research
Inc.
Lynntech Inc.

Project We
Fourier Transform Infrared Phase Shift Cavity Ring Down
Spectrometer
Defect Detection in Water Pipelines Using Ultrasonic Guided
Waves
Catalytic Emissions Reduction System for Outdoor Wood Boilers
Development of a Scalable, Low-cost, Ultrananocrystalline
Diamond Electrochemical Process for the Destruction of
Contaminants of Emerging Concern (CECs)
Functional Chrome Coatings on Hard to Access, Internal
Surfaces of Industrial Parts from an Environmentally Benign
Trivalent Chromium Bath
Pipeline-Quality Methane from Anaerobic Digestion Streams
Microelectrochmical Capillary System for Environmental
Analytical Lab on a Chip

Amount
Awarded
$299,956
$299,960
$300,000
$299,686
$299,981
$300,000
$299,999
Total:
$2,146,352

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P3—Winning the Sustainable Future
On April 25, 2012 EPA announced the winners
of its annual P3 Awards Competition for
Sustainability. More than $1 million was awarded
to university and college teams from across
the country who participated in the 8th Annual
National Sustainable Design Expo on the National
Mall in Washington,  D.C.

The three "Ps" of P3  are People, Prosperity and
the Planet. Established in 2004, the competition
is focused on supporting innovative designs that
benefit people, promote prosperity, and protect
the planet while advancing Sustainability around
the world.

The competition has two phases. In the Phase I,
student teams and their faculty advisors submit
research proposals for a chance to win up to
$15,000 in seed money to research and develop
designs for sustainable solutions to current
environmental and human health challenges.

Phase I grantees are invited to Washington,
DC each spring to display their research at
the National Design Expo. At the Expo, a
panel of experts convened by the American
Association for the Advancement of Sciences
evaluates the projects and passes along their
recommendations to EPA officials for selecting
the winners.

In addition to the coveted P3 Award, winning
teams received additional funding of up to
$90,000 for moving their projects into Phase
II, when they start developing marketable
prototypes of their sustainable designs.

Previous P3 award  winners have started
successful businesses and are marketing the
technologies in the United States and around the
world.

Winners of the 2012 awards include:
•  Appalachian State University for developing
   an artificial wetland suitable for recycling
   of grey water from small businesses for
   immediate reuse.
•  Butte College for developing structural
   insulated panels for building  construction using
   rice hulls, an abundant agricultural waste, as
   the primary raw material.

-------
•  Embry-Riddle Aeronautical University for
   designing a foldable solar power water
   purification system that can fit into a
   backpack for easy transport for use after a
   disaster affecting drinking water supplies.
•  Gonzaga University for developing a simple
   ventilation system for kitchens in rural dwellings
   using electrical power generated from
   thermoelectric cells driven by waste heat from
   cooking fires.
•  Oregon State University for raising awareness
   of pollution associated with the production
   and use of plastic mulch by farmers and
   testing alternative biodegradable mulch
   material.
•  Princeton University for developing, testing
   and deploying an electricity generation
   system that can be transported in a standard
   shipping container and rapidly set up in rural
   communities and post disaster areas.
•  Santa Clara University for developing a fuel
   cell capable of continuous sustainable energy
   supply to meet energy demands in rural
   communities in developing nations lacking
   reliable energy grids.
•  Southern Illinois University- Carbondale for
   developing  methods to extract (recycle)
   metals from coal combustion byproducts
   to reduce mining waste and to produce
   a concrete with reduced carbon dioxide
   emissions.
•  SUNY College of Environmental Science
   and Engineering for studying ways to
   recover struvite, a slow release fertilizer, from
   digested animal manures and assessing its
   marketability.
•  Texas State University - San Marcos for
   converting rice husks, a byproducts of
   agriculture, into a starter material called
   lignocellulose for producing fabrics, biofuel
   and silica nanoparticles.
•  University of California - Riverside for designing
   a solar collector to heat ambient air for use
   in home appliances, such as clothes dryers
   and space heaters, to reduce home energy
   consumption.
•  University of Cincinnati for developing a
   pilot scale system to convert grease from
   restaurants, a waste sent to landfills, to
   renewable biodiesel.
•  University of Connecticut for investigating
   ways to use local industrial byproducts such as
   steal slag and lime kiln dust to control erosion
   and to stabilize roads in Nicaragua.
•  University of Oklahoma - Norman for
   designing, field-testing, constructing,
   analyzing, and documenting a habitat for
   humanity house built of compressed earth
   blocks.
•  Vanderbilt University for developing a
   biohyrid solar panel that substitutes a protein
   from spinach for rare metals  (mined) and  is
   capable of producing electricity.

2072 Honorable Mention winners include:
•  Christian Brothers University for developing
   technologies to improve energy efficiency
   in the building envelope of residences in
   Memphis, Tennessee, that focus on the
   thermal properties of materials, fire safety,
   material stability and cost.
•  Clarkson University for studying the feasibility
   of using waste heat and leachate from a
   solid waste management facility for energy to
   produce biodiesel from algae.

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      •  Drexel University for designing a pilot-scale
         reactor for a local landfill that uses algae to
         produce biofuels from landfill leachate and
         gas.
      •  Missouri University of Science and Technology
         for designing a novel way to reduce the
         energy lost when power coming into a house
         is converted to the current needed by many
         household electronics to run.
      •  Purdue University for designing, building and
         installing affordable "ram" pumps in Haiti to
         improve the availability of water for its citizens.
      •  Rochester Institute of Technology for designing
         a hydrofoil system that harvests energy from a
         river while minimizing the harmful effects that
         dams create for river flow and sediments.
      •  Santa Clara University for developing a high
         efficiency solar absorber/exchanger that can
         bring low cost energy to urbanites who have
         limited space for solar collectors.
              •  Southern Illinois University-Edwardsville for
                evaluating the use of selenium-polluted
                plant waste materials harvested from
                phytoremediation sites to produce selenium-
                enriched edible mushrooms.
              •  University of California - Davis for designing
                and monitoring an affordable green roof
                technology that uses the shading from plants
                to cool roof surfaces and reduce peak
                electricity demand by  up to 75 percent.
              •  University of North Carolina at Chapel Hill
                for creating and implementing a point-of-
                use disinfectant for drinking water that is
                cheap, non-toxic and effective in reducing
                waterborne illness in  developing nations.
              •  University of Texas at Austin for designing,
                constructing and  testing vermicomposting
                (composting with worms) bins to improve
                public health in the Dominican Republic by
                reducing water contamination from organic
                waste.

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Image of Chesapeake Bay taken from the International Space Station.
     Supporting Innovation
     Innovative organizations recognize the
     importance of tapping the collective expertise
     of their staff and encouraging everyone to
     contribute ideas and submit possible solutions
     that support the organizational mission. EPA's
     Office of Research and Development has
     embraced this concept to harness the talent and
     energy of its scientists and engineers.

     The Agency's Pathfinder Innovation Projects
     (PIPs) encourage staff researchers to try bold
     ideas that could produce transformational
     advancements in  environmental and human
     health protection. PIPs reward the ingenuity
     and entrepreneurial spirit of Agency scientists
     and provide seed funding for proof-of-concept
     research.

     Like  EPA's extramural granting programs (see
     previous stories on the STAR grants and EPA's P3
     student competition forsustainability), the PIP
     program employs a competitive review process
     to identify and support the best, most innovative
     proposals.

     External panels evaluate proposals on several
     criteria, including the potential to dramatically
     transform how EPA solves environmental
     problems and the potential for significant
     progress toward sustainability.
Teams selected for their PIP proposals receive
funding and time to work on the research.
Although the awards are for internal EPA studies,
some scientists do work across disciplines
and garner external support. For instance, an
Agency research team collaborated with the
Naval Research Laboratory and NASA on the
International Space Station to test a novel proof-
of-concept satellite system that can monitor
coastal water quality.

In 2012, ten new PIPs—on topics that range
from building a toxicity screening system that
more closely mimics air pollution exposure in
human lung cells, to making risk assessments of
waterborne viruses more reliable—joined  the
growing list of projects that cultivate innovative
solutions to support EPA's mission to protect
human health and the environment.
Learn More about EPA research grants,
fellowships, and awards
•  EPA Extramural Research Funding and Award
   opportunities: www.epa.gov/ncer/
•  EPA's Small Business Innovation Research
   Program: www.epa.gov/ncer/sbir/
•  EPA Research Fellowships: www.epa.gov/
   ncer/fellow/

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Homeland Security
  EPA's Homeland Security research supports the
  Agency's role as the lead federal agency for
  protecting water systems and decontamination
  efforts following incidents involving chemical,
  biological, or radiological contamination.

  The research strengthens the resiliency of
  communities to prepare for and respond to
  contamination incidents. The research enables
  water utility managers, laboratory technicians,
on-scene coordinators, risk assessors, risk
communicators, and emergency responders to
detect, prepare for, respond to, and recover
from terrorist attacks and other disasters.

This section highlights some of the results EPA
researchers and their partners have achieved in
2012 advancing Homeland Security.
  Learn More!

  For more information abut the impact and scope of about EPA Homeland Security Research, please
  visit: www.eDa.aov/nhsrc/.

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EPA researchers develop monitoring and early warning technologies as well as help utilities and communities prepare response for
potential contamination events.
     Protecting Drinking Water Supplies
     The vast majority of Americans need look no
     further than their kitchen faucet to find clean,
     safe, and abundant drinking water. The nation's
     water distribution system is a model of success
     for delivering this vital resource in ways that
     also protect public health. That success is
     underscored by the need for constant vigilance
     to protect water sources and distribution systems
     from deliberate or accidental contamination.
     This was a fact that became clear in the wake
     of the 9/11 terrorist attacks and the subsequent
     mailing of anthrax-tainted letters to U.S. Senators
     and media outlets.
EPA is the primary federal agency responsible
for treating drinking water and decontaminating
drinking water infrastructure in the event of
a terrorist attack or other incident involving
chemical, radiological, or biological agents
introduced into the water supply. These
responsibilities are supported by scientific and
engineering research conducted in EPA's
Homeland Security Research program.

EPA researchers are developing the scientific and
technical solutions needed to secure and sustain
the nation's water systems. A primary goal of
that work is to prevent or minimize the impact

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of any attempted or actual contamination
event. This is done through the development
of monitoring and early warning technologies
and software to provide system-wide, real time
surveillance.

In 2012, EPA researchers continued to advance
the Agency's award-winning CANARY Event
Detection software, a technology that serves
as an early warning system for water utilities.
CANARY is used to quickly distinguish between
day-to-day variations in water chemistry and
those variations from a contamination event.
Researchers are pursuing ways to tap information
collected simultaneously from multiple locations
(rather than each location separately).  In
addition, researchers released a Quick Start
Guide to make the software more accessible
and user-friendly by providing step-by-step,
downloadable instructions.

Along with threat detection and monitoring
tools,  EPA scientists and engineers are also
working to help water utilities, communities, and
the public be better prepared to respond and
recover (decontaminate and clean up) once
contamination occurs. To learn how to better
respond to biothreat agents in drinking water,
they studied the effectiveness of chlorination and
chloramination for destroying anthrax.

They also developed a standard protocol—the
Standardized Persistence and Decontamination
Experimental Design Protocol—that research
laboratories across the country can follow when
investigating the decontamination of water
pipes. The use of such a protocol will facilitate
comparability of research findings across studies
and advance consistency and confidence in
decontaminating water infrastructure.
Need to Know: Helping
Water Utilities Prepare

As the lead federal agency for water
security, EPA researchers play a critical role
in helping their partners at water utilities and
in the response community better prepare
for emergencies. In 2012, EPA's National
Homeland Security Research Center and
the Water Information Sharing and Analysis
Center (WaterlSAC) teamed up to deliver
the webcast "Anticipating the Public's
Questions during a Water Emergency." The
webcast provided practical information that
drinking water utilities can use in formulating
effective communication plans. These
plans can then be employed during a water
contamination event.

EPA also released a companion publication,
Need to Know: Water Emergency Questions,
presenting practical information that crisis
communicators can directly apply to
planning and response. The publication
is the result of a series of interviews and
webinars EPA conducted to identify the
anticipated information needs of water
utilities and the public following events that
threaten the safety of drinking water. The
report is available for downloading at: l.usa.
aov/QovLtF.

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           •*"»  v •           * "v
                   -
                             .^
                           1*
                                                  •


                                    . -
                
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Department of Health and Human Services, the
Department of Defense, and others.

Collectively they are working to find ways to
inform the design of emergency response and
decontamination procedures to eliminate
the hazards posed by anthrax spores after
an initial release. A focus of the program is to
explore how anthrax spores might renter the
air,  ("reaerosolization") from surfaces where
they settled after first  being released. SPORE
researchers conducted wind tunnel tests
using anthrax surrogates and have found that
reaerosolization of anthrax spores can occur
even after the spores have settled, a key fact to
consider for cleanup  and disposal operations.

Another effort is underway in collaboration with
the Centers for Disease Control and Prevention
(CDC) to understand how best to eliminate
the threat of an anthrax release in water.
Researchers conducted seven laboratory-
based studies in water using anthrax surrogates
along with other microbes identified as potential
bioterrorism agents.

Researchers from the EPA/CDC partnership
found that the effectiveness of chlorine and
other disinfectants in  killing the various biological
contaminants depended on  how many microbes
are present,  the pH and temperature of the
water, the type and quantity of organic and
inorganic particles in  the water and the kind of
material used in construction of the pipes. The
studies are providing  important information to
EPA's Office of Water and water utility managers
who may have to deal with such biological
contaminants.
The results of EPA's homeland security research
will better inform and prepare the Agency and its
stakeholders in responding to a terrorist threat or
attack. These tools and techniques will result in
quicker and more cost-effective response to and
recovery from not just terrorist attacks, but other
disasters, both natural and accidental.









-
'


.

                                                Researchers conducted tests using this wind tunnel to determine
                                                that anthrax spores can reaerosolize, even after settling to the
                                                ground.

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I-WASTE is a web-based tool that provides a suite of waste management information for cleaning up after natural disasters, terrorist
attacks, and widespread outbreaks of animal disease.
     Supporting  Emergency Response and Recovery
     Tragic events from the terrorist attacks of 2001
     to the recent destruction left in the wake
     of Superstorm Sandy have made images of
     emergency response all too familiar: emergency
     crews rush in, search and rescue operations
     commence, and those affected are tended to
     and moved to more secure areas. Research
     products addressing terrorism response and
     recovery can also be employed in other
     situations.

     For the past ten years, EPA's homeland security
     researchers have been conducting research that
     supports federal, state, and local decision makers
working to prepare emergency responders and
local communities with the information they
need.

In 2012, EPA researchers continued to work with
partners from the Department of Homeland
Security on the Wide Area Recovery and
Resiliency Program (WARRP). The program is a
collaborative effort to develop and demonstrate
actions to reduce the time and resources
needed to recover from a large-scale chemical,
biological, or radiological event, such as one
affecting  military installations, urban areas, or
critical infrastructure.

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                                                                                         Page 99
Working with EPA's Office of Solid Waste and
Emergency Response, public health officials, and
waste management experts, EPA researchers
have developed plans and tools to provide
real-time information on waste disposal. EPA
researchers updated the Agency's Incident
Waste Assessment System and Triage Estimator
(I-WASTE), a web-based, easily accessible tool
that provides a suite of waste management
information for cleaning up after natural disasters,
terrorist attacks, and widespread outbreaks of
animal disease.

I-WASTE 2012, available at http://bit.lv/12fs1EK.
offers emergency response planners information
on waste characterization, treatment, and
disposal options, and how to incorporate safe,
efficient waste management operations into
emergency response plans.

To support emergency response operations
involving hazardous biologicals and chemicals,
in 2012 EPA researchers released SERRA 4.0
database (SERRA is an  acronym for "Support for
Environmental Risk Assessment). The "knowledge
base" provides an extensive compilation
of scientific information to assist scientists,
emergency personnel, and decision makers
responsible for planning and managing cleanup
operations, including mitigating hazards, in the
aftermath of a terrorist event.





-------
Methods presented in SAM will allow for quicker and more efficient and effective lab analysis, communication, and support in the
event of an emergency.

     Ready to Respond: Improving the Nation's
     Emergency Preparedness
     In the event of an environmental disaster
     involving potential contamination from radiation,
     biological, or chemical agents, the need for
     fast, accurate laboratory analysis is essential for
     supporting emergency response, recovery, and
     remediation operations. In the ten years since
     EPA's Homeland Security Research program was
     established, Agency researchers have helped
     the nation become significantly better prepared
     for just such response activities.

     Agency scientists increased the nation's ability
     to analyze large quantities of environmental
     samples following the intentional or unintentional
     release of hazardous chemical, biological, or
     radiological (CBR) substances. To accomplish
     that, they have established the Environmental
     Response Laboratory Network (ERLN), a
nationwide network of analytical labs that can
quickly support large-scale responses.

In support of the Network, EPA researchers
have prepared Selected Analytical Methods for
Environmental Remediation and Recovery (SAM)
-2012, the latest update of a compendium
of methods for use in analyzing samples for
chemical, biological, radiological, and biotoxin
contamination.

The standardized analytical methods
presented in SAM  allow labs to share samples,
increasing the speed of analysis, improving
data comparability, and simplifying the task of
recruiting and using commercial labs for rapid
analytical support in the event of an emergency.

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                                                                                            Page 101
Researchers have prepared the latest update of a compendium of methods for use in analyzing samples for chemical, biological,
radiological, and biotoxin contamination.
    EPA researchers worked in collaboration with the
    Agency's Office of Emergency Management,
    the Office of Ground Water and Drinking Water,
    the Office of Radiation and Indoor Air, and EPA
    Region 10 (serving the Pacific Northwest) to
    update and improve SAM 2012.
EPA has developed companion documents to
provide information regarding field screening
equipment, sample collection, rapid screening
and preliminary analysis equipment, and sample
disposal information to supplement the analytical
methods included in SAM 2012.
    The latest version of SAM 2012 incorporates
    revisions to the list of target sample types and
    provides the latest analytical methods and
    procedures. Method updates included are
    based on the availability of new methods or
    data, and now present more than 200 method
    summaries  for biological, chemical, and
    radiochemical agents.
In addition to providing access to the latest
document, EPA's SAM-2012 website (www.epa.
gov/sam) hosts a Methods Query, sample matrix
type, and specific capabilities of a laboratory.
The site also has full documentation of publicly
available laboratory methods, companion
documents, sample collection procedures, and
links to technical contacts and key collaborators.
    Learn More about EPA Homeland Security Research
    • EPA Homeland Security Research: www.epa.gov/nhsrc/
    • Read the Homeland Security issue of EPA's Science Matters Newsletter, http://epa.gov/research/
      sciencematters/september2011 /index.htm
    • Download EPA's Homeland Security Strategic Research Action Plan, 2012-2016: http://epa.gov/
      research/sciencematters/september2011 /index.htm.

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United States Environmental Protection Agency

                                                        US EPA Research
                                                        @EPAresearch
                                                        Office of Research & Development is the scientific
                                                        research arm of the US EPA.
                                                        11  states + DC •  http://www.epa.gov/research
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