United States Chemical Coordination Staff
Environmental Protection offjce of Pesticides and Toxi£ Substances
j»pf Agency Washington DC 20460
sPw
PA Extramural Activity
M
Volume II, Issue 2
May 1983
EPA 730-R-83-003
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, O.C. 20460
MEMORANDUM
SUBJECT:
Assistant Administrators
Aft Budget Officers
Regional Administrators
Agency extramural Activity Report (EARS for
Toxins-Related Projects, Volume IT, Issue 2
Volume II, Issue 2 of the Extramural Activity Report (EAR!,
prepared by the Chemical Coordination Staff (CCS) of the office
of Pesticides and Toxic Substances is attached. It includes
descriptions of toxics-related projects that have been modified
(including new tasks and work assignments) under existing
contracts, as well as any new contract, grant, cooperative agree-
ment or interageney agreement not included in the previous (January)
issue of the EAR.
The EAR is developed in consultation with the particular
programs involved with each project. The primary purpose of the
EAR is to aid in the coordination, planning and development of
extramural efforts by providing a source of information to deter-
mine which extramural efforts are currently being developed or on-
going throughout the Agency. By consolidating or coordinating
these efforts, their quality and consistency can be improved and
extramural duplication can be avoided. We strongly encourage yon
to use the EAR as a tool in the procurement process.
To facilitate use of the EAR, the projects have been indexed,
where possible, by chemical, industry and environmental media.
These indices are listed at the end of the document.
CC
numbers
S will continue t-o maintain a log of the names and phono
for the project officers, or appropriate contacts for each
project to ensure that only legitimate EPA users are put in touch
with the project/program office as well as to track the utilization
of the
CCS plans to distribute a supplemental issue of the EAR in
late summer wh»ch will include a description of toxics-related
lovel-oE-eJCort, and incrementally funded contracts for the
omce of Research and Development, and any new extramural efforts
identified by you, but not included in this issue.
_ In keeping with printing limitations, the BAR cannot he
furnished to every EPA project officerj therefore, ensuring the
availability of this document, to appropriate personnel within
your office is critical to its successful utilization.
If you have any questions, suggestions, or want to contact
the project ofticer for any of the projects listed in the EAR,
please call Joanne LaBaw, Peter Hahor or Arnie Bdelman of CCS at
3B2-2249. In addition to the KAR, the Office nf. Research Grants
and Tenters has information available on FY 81 research grants
For information on these latter projects, contact. Richard Harland
lit Administrator
teat ion
Don R. Clay
Acting Assistant Administrator
£or Pesticides and
Toxic Substances
Attachment
Office Directors
Division Directors
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Hcknowl«Ige«eiit
The Chemical .Coordination Staff of the Office of Pesticides and Toxic
Substances wishes to express its appreciation to the EPA project managers,
contract officers? and program budget officials, the Grants Administration.
Division and the Office of Research Grants and Centers, who assisted in the
development of this document by providing contract and grant information and
the timely review of draft descriptions. Without their enthusiastic
cooperation, production of this document would not have been possible.
Walter w. Kovaliek, jr.
Information concerning the project officers names and phone number for these
contract efforts may be obtained from Joanne LaBaw (382-3395), Peter Bahor
(382-2259) or Arnie ifllenian (382-2249) of the Chemical Coordination Staff.
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OF
Fate and Transport/Materials Balances ........... 1
Health/Environmental Effects.................................... 2
Health Effects , 4
Environmental Effects. ,, 13
Exposure •„.......„.. 18
Risk. 20
Industrial studies[[[ 23
Economic Studies 25
Treatment Technology Development/Evaluation 29
Waste Mangement/Resource Recovery. 34
Policy Studies/Regulatory Control Options 38
Methodology Development/Validation
o Chemical Analyses 42
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Statistical Analyses ' ...
•"•«»<»aaaaaOaaOaa,»!>aaaeaaa«aeoaaOa»aa ££
Modeling. ...aoae ,0
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Data Base Development «.„ ... 50
Sampling Analysis and Monitoring
o Chemical Analyses—Specific Topics 51
o Environmental Monitoring, 080 53
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FATETOAMSPORT/MATERIALS BALANCES
Title- Of f ice/Pi vision
Description
Workshop on Biodegradation
in Fate Modeling
Cooperative Agreement
The objectives .of the workshop will be to:
(1) develop a better understanding of state-of-
the-art methods for predicting biodegradation
rates; (2) identify the most promising methods or
approaches now being used or proposed} and
(3) suggest research and development programs that
are most likely to provide useful information on
biodegradation kinetics in the future.
Analytical Chemical
Support for Studies on the
Fates and Effects of Toxic
Organic Compounds in the
{ferine Environment
Grant
These studies will include chemical analysis of
selected organic compounds present in field
samples. In addition, this agreement will allow
collaboration in the design, implementation, and
interpretation of chemical studies on the fates
and effects of toxic organic compounds in the
marine environment.
(Chemical; Toxic organic chemicals) • •
(Media: Water)
Atmospheric Fates of Toxic
Organics
Cooperative Agreement
This project entails prediction of ozone and
hydroxyl radical reaction rates and mechanisms.
(Chemical; Toxic organic chemicals)
(Media:Mr)
Effluent Guidelines
Support
OWRS/Effluent Guidelines Division
See: Policy Studies/Regulatory Control Options
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HEALTH/EHVIROHMENTAL EFFECTS
Title
Office/Pivision
Description
Development of Molecular
Connectivity for
Estimation of Toxicity'and
Environmental Behavior of
Organic Molecules
Cooperative Agreement
This cooperative agreement will provide for the
development and extension of the molecular connec-
tivity method,,
Evaluation and Control of
Potential Health or
Environmental Problems
Associated with Used Oil
Recycling or Disposal
OSW/Hazardous and Industrial
Waste Division
The first task will provide an assessment of
certain waste oil management practices
including: a review a waste oil composition data
to determine constituents in the waste oil that
may be of concern; a review of available data on
current management practices and using such
information as fate and transport models and
engineering judgment draw conclusions as to the
potential for health and environmental problems
resulting from current management procedures
The second task will identify, describe and obtain
engineering or unit cost estimates for methods or
technologies that could be used to control risks
or hazards associated with waste oil storage,
recycling and disposal.
CChemical; Waste oil)
(Media: Land)
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HEALTH/ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Evaluation of Health and
Environmental Effects of
Proposed Regulations for
Coke Ovens
OPRM/Office of Program Analysis
This work assignment will provide support for a
review of the draft proposed regulations and sup-
porting documents for coke oven emissions.
Determinations will be made as to whether the
range of control options considered and the cost
estimates provided are accurate and whether
estimates of human health effects of controlled
and uncontrolled emissions are reasonably accurate.
(Chemical; Coke oven emissions)
(Media: Air)
State Epidemiologist Data
Management Program
OPTS/Chemical Coordination Staff
This new grant will identify state capabilities,
data resources, utilization and needs to encourage
the integration of environmental and health data.
State Legislative
Initiatives and Trends
Toxic Substances
Management
OPTS/Chemical Coordination Staff
in
This grant will compile and assess each state's
1983 legislative initiatives and analyze general
trends in integrated toxics management.
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HEALTH EFFECTS
Title
Office/Division
Development of In Vitro
Testing Systems for
Hepatic, Renal, and
Cardiac Toxicity
Assistance Amendment
Carcinogenic Activity of
Reaction Products of Humic
Substances and Drinking
Water Disinfectants
Cooperative Agreement
Human Exposure to
Formaldehyde Monitored by
Several Assays for
Mutagenesis in Man
Cooperative Agreement
Description
This proiect will conduct 90-day studies of target
organ toxicity in vivo in rats for carbon
tetrachloride and endothal. Calcium ATPase studies
on liver as effected by chlorinated hydrocarbons
will also be performed.
(Chemical: Carbon tetrachloride, Endothal,
Chlorinated hydrocarbons)
This project will assess the carcinogenic activity
of reaction products of alternate drinking water
disinfectants and humic acids.
(Chemical: Disinfectants, Humic acids)
(Media: Drinking Water)
The purpose of this cooperative agreement is to
evaluate the ability, sensitivity and precision of
several assays to predict a genotoxic hazard,
(Chemical; Formaldehyde)
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HEALTH EFFECTS
Title
Office/Division
Effects of Route of
Administration on
Carcinogen Disribution and
Metabolism in Mouse
Strains of Differing
Sensitivities to Tumor
Induction
Assistance Amendment
Chemical Axonopathy
Detected by Stimuli of
Increasing Frequency
Assistance Amendment
Evaluation of Inhalation
Toxicity of Hazardous
Chemical Air Contaminants
Cooperative Agreement
Description
Distribution and metabolism studies are planned
using 3H-benzo(a)- pyrene and 7,12-dimethylbenz(a)
anthracene. Activity in skin? liver, lung, and
forestomach will be studies., Comparisons will be
made in the SENCAR versus BALB/c mice. Oral
applicaton is to be compared to topical.
(Chemical; 3H-Benzo(a)pyrene
7,12-Dimethylbenz(a)anthracene)
This project will develop and validate the utility
of several functional approaches to testing
paripheral nerves for signs of neurotoxicity.
This project will evaluate the potential toxicity
of selected hazardous compounds present in the am-
bient air. Major endpoints examined related to
host defenses against infectous diseases.
(Chemical; Hazardous chemicals)
(Media:Air)
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HEALTH EFFECTS
Title
Office/Pivision
Neuropathology of
Trimethyltin( TMT)
Intoxication
Cooperative Agreement
Toxicological Evaluation
of Selected Organic
Contaminants Found in
Drinking Water
Cooperative Agreement
Impacts of Toxicants,
Pathogens, Climate on
Reproduction
Grant
Description
This cooperative agreement will provide neuro-
pathology support in an effort to understand th'e
neurotoxicology of trimethyltin. Results will be
correlated with behavioral and physiological
studies.
(Chemical: Trimethyltin)
The proposed studies will evaluate the potential
advers.e health effects of selected organic
contaminants found in drinking water. These data
should assist U.S. EPA in standard setting or
issuing health advisories.
(Chemical; Organic chemicals)
(Media: Drinking water)
This research will model the impact of toxicants,
pathogens, and climate on small mammals.
Physiological parameters for screening and
synergism determinations will be identified and
when mechanisms of action when synergism is
observed they will be assessed.
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HEM.TH EFFECTS'
Title
Of f i ce/ Pi vi s i on
A Single Gene Mutogenesis
System in D. Melanogaster
Grant
Reproductive/Teratologic
Assessment and
Pharmacokinetics of
Selected Organochlorine
Contaminants .in Drinking
Water
Cooperative Agreement
Environmental Carcinogen
Perturbation of
Differentiation and
Induction of
Ca'rcinogenesis in Human
Epithelial Cells
Grant
Description
Ttiis study will produce knowledge on the mechanism
of the nutagenic process as related to the ros'y
locus and elucidated by enzymatic, inraunologic and
"molecular analysis.
The purpose of this cooperative agreement is to
assess the effects of selected organochlorine con-
taminants of drinking water on reproduction and
development.
(Chemical; Organochlorines)
(Media: Drinking water)
nils grant will provide a study of the relation-
ship between metabolic activation of specific air-
borne carcinogens, carcinogen-DNA adduet forma-
tion, expression of the carcinogen insult, and
perturbation of the differentiation process of the
target cells.
(Me di a: Mr)
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Title
Of fi.ce/Pi vi sion
Description
Respiratory
Carcinogenicity of Diesel
Fuel Emissions and Related
Substances
Assistance Amenderaent
This project will determine the carcinogenic
potential of diesel fuel emissions and particle
extracts as compared with other known carcinogens.
(Chemical! Diesel fuel emissions)
(Media? Air)
Behavioral Tests for Toxic
Exposure
Cooperative Agreement
The purpose of this cooperative agreement is to
develop and validate a quick, objective and reli-
able behavioral test of sensory dysfunction,,
Lead Emissions and Blood
Lead Levels
OPRM/Office of Policy Analysis
This work assignment will provide research and
analysis of new data sources that estimate the
relationship between lead emissions and the
measured levels of lead in the blood of sensitive
populations.
(Chemical; Lead) • . . •
(Madia: Mr)
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HEALTH EFFECTS
Title
Office/Division
Description
lexicological Support
Office of Drinking Water/Criteria
and Standards Division
This project will prepare health effects criteria
documents for the revised primary drinking water
regulations and health advisories. Support will
also be provided for the activities of ODW's
Outreach Program (Emergency Response, etc.)
(Media: Drinking .water)
Preparation of "Current
Awareness" Reviews on
S t r-uc tur e -Ac t i vi ty
Relationships: Support
Documents for the •
Assessment of Health
Effects of Chemical
Substances
OTS/Assessment Division
This ' contract will develop an enhanced
understanding of structure-activity relationships
in particular chemical classes so that inferences
can be drawn about the potential hazard of new or
existing substances for which adverse health
effects data are lacking*
(Chemicals; - Difurcxanthone-type alkylating
agents
- Polynuclear lactone alkylating
agents
Tannins and flavonoids
- Hepatotoxins containing
anthraquinone nucleus
- Nitrosamine congener
alkylazoxymethanol type alkylating
agents
- Polyhalogenated biphenyls and-
related aromatics
- Industrially-used modified lipid
chemicals of plant origin)
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HEALTH EFFECTS
Title
Office/Division
Description
Technical Support for
Future Epidemiological
Studies
OTS/Health and Environmental
Review Division
The purpose of this incrementally funded
interagency agreement is to provide technical
support to determine the feasibility of future
epidemiologic studies. A mechanism will also be
provided for carrying out these studies.
Epidemiologic and
Statistical Analysis
OTS/Health and Environmental
Review Division
The purpose of this interagency agreement is to
allow time-sharing on the National Insitute of
Health computer. This computer is used by
OTS/HERD statisticians and epidemiologists to ana-
lyze health effects data, particularly carcino—
genicity data, for low dose extrapolations.
Phase II of Gene Tox
OTS/Health and Environmental
Review Division
The purpose of this interagency agreement is for
completing Phase II of Gene-Tox. Gene-Tox is an
on-going effort to review and evaluate, using the
published literature, selected bioassays for muta-
genicity and related endpoints.
In Phase II a computerized data base of over 3700
chemicals is being analyzed to determine which
tests or combination of test may be used for:
(1) routine screening; (2) testing specific
classes of chemicals for their ability to induce
genetic damage; and (3) discriminating between
carcinogens and noncarcinogens.
10
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HEALTH EFFECTS
Title
Office/Division
Description
Establishment of Breeding -
Colony for Teratology and
Reproduction Studies
Cooperative Agreement
The collaborative research is directed toward
characterizing the teratogenic potency of the
nratagenic agents ethylnitrosourea (ENU) and
methynitrosourea (MNO), with particular emphasis
on the pattern of limb malformations induced by
these agents.
(Chemicals Ethylnitrosourea, Methylnitrosourea)
Carcinogenic Potential of
Arsenic Compounds in
Drinking Water
Cooperative Agreement
This project will complete the assessment of
Arsenic in rat liver foci assay to determine
whether various forms of arsenic behave as tumor
initiators or promoters, A fourth year of study is
being awarded to more fully investigate the forma-
tion of renel twnores in Arsenic exposed animals
under this protocol.
(Chemicals Arsenic compounds)
(Media: Drinking water)
Plasmid Gene Transfer to
Indegenous Organisms
During Domestic Waste
Treatment and Disposal
Grant
This basic research will study the mechanisms of
transfer of drug resistance in biological treat-
ment processes.
11
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HEALTH EFFECTS
Title
Of fice/Pivi s io n
Description
Neurobehavioral Assessment
of Hazardous Was te
Grant
This cooperative agreement will provide for the
organization and holding of a conference which
focuses on human disease models of neurotoxicity
and • publish the results of the conference,
distributing them to the appropriate scientific
community.
Evaluation of Human Tissue
Supplements for Metabolism
of Xenobiotics in
Mutagenesis Studies with
V79 Cells and Human
Fibrob lasts
Cooperative Agreement
This project will evaluate the possibility of
using material derived from human tissue as
supplements for metabolic activation in mammalian
cell mutagenesis bioassays to identify
environmental materials hazardous to humans.
Effects on Prenatal
Development of the
Interaction Between
Malnutrition and Exposure
to Toxic Agents .
Cooperative Agreement
This cooperative agreement will investigate the
interaction between environmental agents and
protein-calorie malnutrition during pregnancy for
potential synergistic effects.
12
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ENVIRONMENTAL EFFECTS
Title
Office/Pivision
Description
Field Verification of
Bioassay Results at Toxic
Waste Sites in Three River
Drainage Systems
Cooperative Agreement
Provide the field research required to verify the
effectiveness of laboratory bioassay in predicting
environmental impact of toxic chemical release
from hazardous waste sites.
(Chend.cal; Hazardous wastes)
(Media; Land, Water)
Cooperative Agreement to
Develop Data bases for
Terrestrial Plants
Responses to Organic
Chemicals
Assistance Amendment
The objectives of this cooperative agreement are
to: (15 prepare a computer data base on organic
chemicals and their influence on the growth and
development of terrestrial plants following
prototype PHYTOTOX and (2) prepare a computer
data base on organic chemicals and their uptake and
accumulation by terrestrial plants,
(Chemical: Organic chemicals)
Chemical Reactions'of
Aquatic Humics with C
Cooperative Agreement
CIO,
and Chloramines
This cooperative agreement will provide measure-
ments of byproducts of reactions of disinfectants
with natural organic materials to extend knowledge
of the nature of- these byproducts and their quan-
titative significance.
(Chemical: Disinfectants)
Complex Effluents Toxicity
Testing Program
Office of Water Enforcement/
Permits Division
See: Policy Studies/Regulatory and Control Options
13
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Title
Of fice/Division
Description
Assessment of Impact of
Highway Heavy Metals on
Roadside Stream Ecosystems
Grant Agreement
This project will observe the change in heavy
metals concentrations in several components of
stream ecosystems with exposure to highway heavy
metals and assess the impact of time on stream
biota.
(Chemical: Heavy metals)
(Media: Water)
Physiological Aspects of
Heavy Metal Uptake in
Algae
Assistance Amendment
This research is studying polyphosphate formation
using electron microscopic techniques and
organisms from culture and from collections of the
"Hudson system," and the association of copper,
cadmium, and lead with the polyphosphate granules.
(Chemical; Copper, Cadmium, Lead)
Environmental Monitoring
and Assessment of Pollution
Impact on Ecosystems
Assistance Amendment
See: Sampling Analysis and Monitoring —
Environmental Monitoring
Environmental Effects of
Drilling Along the
Continental Shelf
Office of Water Enforcement/
Permits Division
This incremental funding action will provide
environmental data on the effects of drilling,
fluids and cuttings released into waters along the
continental shelf. An. annual supplement which
summarizes the results of laboratory and field
studies on drilling fluids will be provided.
(Media: Water)
14
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ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Field Assessment of
Laboratory-Derived Test
Protocols and Water
Quality Criteria
Assistance Amendment
This project consists of two components:
(1) evaluation of the suitability of laboratory
derived criteria for protection of aquatic life?
and (2) description of the effects of pentachloro-
phenol (PCP) on microbial and algal communities.
(Chemical: Pentachlorophenol)
(Media: Water)
Aquatic Ecosystem Effects
of Process Waters Produced
by Synthetic Fuel
Te chnologi es
Cooperative Agreement
This project will evaluate the toxicity of dis-
charges from oil shale mining and processing coal
gasification and tar sandsj conduct experiments to
evaluate individual synfuel toxicants and mixtures
for use in validating risk assessment units; and
perform literature searches on the toxicity of
synfuel related wastes to be used in enlarging the
AQUIRE computer data base.
(Chemical; Synfuels)
(Media: Water)
Aquatic Toxicity Testing
and Criteria Document
Development
Assistance Amendment
The objectives of this study are to extend and
further develop (a) the acute and chronic toxicity
tests for solid waste extracts, (b) the supporting
technical information for the ammonia Criteria
document, and (cr) the comparative toxicology data
to be used for determining the relationship of
species sensitivity to industrial chemicals.
(Chemical: Hazardous wastes. Ammonia)
15
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ENVIRONMENTAL EFFECTS
Title
Office/Pivision
Description
Computer Simulation
Modeling of Terrestrial
Ecological Effects from
Industrial Chemicals
Assistance Amendment
The overall objective of this project is to
develop computerized system models for assessing
the effects of man-made chemicals on ecosystem
processes and dominant species.
Biodegradation of Organic
Pollutants
Cooperative Agreement
This project consists of two studies designed to
examine the fate of xenobioties in aquatic
Environments.
(Chemical; Organic chemicals)
(Media: Water)
Effects Assessment of
Selected Chemicals on
Estuarine and Marine
Organisms
Cooperative Agreement
This cooperative agreement will provide for
completion of a series of toxicity tests with
selected pesticides and certain non-target
estuarine or marine animals. The chemicals to be
used will include fenthion and Static and
flow-through acute tests will be completed with
Mysiodopsis bohia.
(Chemical: Fenthion, Naled)
16
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ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Effect of Chemical Form
and Environmental Toxieity
of Heavy Metals to
Microbes and Microbe-
Mediated Ecologic
Processes
Assistance Amendment
This project will determine the effects of heavy
metal pollutants as influenced by the psysio-
chemical characteristics of aquatic and
terrestrial ecosystems into which they are
deposited, on microorganisms.
(Chemical; Heavy metals)
(Media: Land, Water)
Effect of Concentration of
Organic Chemicals on Their
Biodegradation
Cooperative Agreement
This project will study factors influencing the
rates of mineralization of trace concentrations of
organic compounds in aquatic environments
including effects due to the presence of sorptive
surfaces and natural screening organic materials
and to "the involvement of cometabolism will be
determined.
(Chemical; Organic chemicals)
(Media: Water)
Interactions between
Microbiota and Persistent
Pollutants in Marine
Sediment
Assistance Amendment
This project will examine the effects of pollutant
loading on microbial biomass and activities in
estuarine and salt marsh sediments, and to
determine the mineralization rates of selected
organic pollutants in pristine and impacted
sediments.
(Chemical: Organic chemicals)
(Media: Sediments)
17
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EXPOSURE
"Title
Of f ice/Division.
Pesticide Exposure
assessment of Strawberry
Harvesters
Cooperative Agreement
Development of a Field
Methodology and Model to
Estimate Commuter
Exposures to Air Pollution
Using Personal Exposure
Monitors
Assistance Amendment
Colorado Pesticide Hazard
Assessment Project
Cooperative Agreement
De s c ription
Develop scientific data on the magnitude and
effects of exposure to pesticides on the health of
the U.S. population.
(Chemical: Pesticides)
This project will develop a field methodology to
estimate human exposure to air pollutants asso-
ciated with micro-environments heavily influenced
by exhaust from motor vehicles,
(Media* Mr)
This project will develop scientific data on the
magnitude and effects of exposure to pesticides on
the health of the U.S. population.
(Chemical: Pesticides)
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EXPOSURE
Title
Office/Division
De s cription
Exposure Assessments for
Comprehensive and Priority
Chemical Assessments
OTS/Exposure Evaluation Division
This contract modification will provide exposure
profiles for human and nonhuman populations
exposed to existing chemicals and proposed chem-
icals Cor changes in production, use or disposal
patterns of existing chemicals). Exposure will be
assessed by evaluating: (a) the environmental
materials balance of the chemical (e.g., produc-
tion, use, transportation, spills,- fugitive emis-
sion, indusrial and municipal effluents, and non-
point sources); (b) environmental transport and
transformation fate of the chemical? (c)
monitoring data on the presence of the chemical in
air, land, water, sediment, food, and drinking
water; • and (d) the number and distribution of
exposed populations (humans and nonhumans).
Studies include assessing occupational exposures,
estimating exposures from disposal and certain
toxic wastes and from food and drinking water; and
providing Premanufacture Notification (PMN)
support to OTS.
(Chemicals:
Vermicttlite
DEHP
Asbestos
Formaldehyde
1,1,1-Trichloroethane
Tetrachloroethene
Di chloromethane
Tetrachlorome thane
Trichloroethene
Trichlorotrifluormethane
PCB's
NTS
MBOCA
Ethoxyethanlol
Ethoxyethanol acetate
Methoxyethanol
Methoxyethanol acetate)
(Media; Air, land, water, drinking water)
19
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RISK
Title
Office/Division
Description
Analysis and Ranking of
Health Evidence for
Hazardous Air Pollutants
OPRM/Office of Policy Analysis
This work assignment will entail ranking 37 sus-
pect hazardous air pollutants (which are candi-
dates for listing and regulation under Section 112
of the Clean Mr Act). Factors to be considered
in this ranking process include: toxic potency,•
emissions, exposed population and persistence in
the environment. An examination will be performed
on the type and quality of evidence for the chemi-
cals posing the greatest risk.
(Media: Mr)
Risk Assessments of
Contaminants
Office of Drinking Water
This project will provide advice on the employment
of pharmacokinetic data in risk assessments of
contaminants in drinking water.
(Media; Drinking water)
Existing Chemical Risk
Assessment Support
Services
OTS/Assessments Division
The purpose of this contract is to provide tech-
nical support to the existing chemicals program by
preparing hazardous risk assessments in support of
TSCA sections 6 and 8 existing chemicals evalua-
tions.
20
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RISK
Title
Office/Division
Description
Pre-Chemical Hazard
Identification-Profiles
(CHIP) Screening/CHIP
Preparation/Post CHIP
Follow-up Support
OTS/Assessment Division
The purpose of this Interagency Agreement is to
support the development of Chemical Hazard
Identification Profiles for existing chemicals.
(Chemical: Acetaldehyde
1-Ghloro-2-nitrobenzene
1-chloro-4-nitrobenzene
2,4-Diaminoazobenzene
2,3-Dichlorodioxane
2,2,-Dithiobis (benzothiazole)
1, 2, 3 ? 4 ? 7 j 7-Hexachloronorbornadien
Tetrabromoethane
iso-Butanol
p-Chlorobenzotrichloride
C.I. Disperse Yellow 3
DSC Red No. 9
Melamine
n-Propanol
Pentachloroethane)
Analysis of Risk/Benefit
Ratios on Pesticide Use
Affecting the Economy of
California and Other
States
Assistance Amendment
See: Economic Analysis
21
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RISK
Title
Office/Division
Description
Health Risks associated
with Non-Point Sources of
Pollution of Water
Cooperative Agreement
This project will determine if a swimming-
associated illness can be observed in water
contaminated with non-hunan wastes from dispersed
sources, and if so, does the. rate fit the model
established by previous EPA freshwater health
effects studies.
(Media: Water)
22
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INDUSTRIAL STUDIES
Title
Office/Division
I>e scri p t io n_
Industrial Data Gathering
and Analysis
OTS/Management Support Division
The purpose of this contract is to provide
information^ particularly unpublished information,
and data analysis in the areas of chemical
production, use, adverse effects, and economic
impacts.
(Industry^ Chemical manufacturers)
Development of Effluent
Standards and Limitations
OWRS/Effluent Guidelines Division
The following are mission contracts Which have
received incremental fundings* These projects are
intended to provide assistance in the development
of effluent standards and limitations for the
industries listed. These efforts will provide
national standards or guidance to the National
Pollutant Discharge Elmination System (NPDES) and
pretreatment standards for use by Publicly Owned
Treatment Works (POTW's).
(Indus trijesj
o Electrical and electronic component,
electroplating, photographic processes and
equipment supplies.
o Metal finishing industries: electroplating
and painting.
o Mill finishing, coil coating, porcelain
enameling, battery manufacturing, plastic
molding and forming industries.
23
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INDUSTRIAL STUDIES
Title
Office/Division
Description
Development of Effluent
Standards and Limitations
(continued)
OWRS/Effluent Guidelines Division
o
Nonferrous metals manufacturing (Phase I),
aluminum forming and copper forming
industrial categories? and nonferrous
manufacturing (Phase II) and nonferrous
forming categories.
Metal molding and casing (foundry)
industries.
o Wood industries, including pulp and paper
textile, timber, soaps and detergents
manufacturing, adhesives and sealants, paint
and ink, printing and ink, printing and
publishing, gum and wood chemicals, and
Pharmaceuticals.
o Food and leather industries)
o Inorganic chemical manufacturing, organic
chemical manufacturing, plastics, rubbers,
and pesticides.
o Energy and Mining Industry
(Media: Water)
Statistical Methodology
for Industrial
Environmental Research
Cooperative Agreement
See: Statistical-Analysis
24
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ECONOMIC STUDIES
Title
Qf fie e /Pi vi s io n
Description
Analysis of Risk/Benefit
Decisions of Pesticides
Use Affecting the Economy
of California and Other
States
Assistance Amendment
Analyses of the costs and benefits of specific
pesticides and non-chemical controls.
(Chemical; Pesticides)
Evaluation of Health and
Environmental Effects of
Proposed Regulations for
Coke Ovens
OPRM/Office of Program Analysis
See: Health/Environmental Effects
Southwest Regional Project
to Assess Crop Loss Due to
Photochemical Oxidants and
Sulfur Dioxide
Cooperative Agreement
The primary objective of this research project is
to define the relationships between yield of major
agricultural crops and doses of ozone. This
information will partially fulfill the need for
data required to assess economic consequences in
the U.S. from crop exposure to gaseous air pollu-
tants .
(Chemicals Photochemical Oxidants, Sulfur
Dioxide)
(Medias Air)
Pesticide Usage Survey
OPP/Benefits and Use Division
See: Policy Studies/Regulatory and Control
Options
25
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ECONOMIC STUDIES
Title
Office/Division
Description
Analysis of Cost Benefits
of Crop Pesticide Use
Cooperative Agreement
Economic Impacts of Diesal
Particulate Emissions
Control
OPRM/Office of Program Analysis
The purpose of this project is to evaluate the
economic impacts of pesticide use in Southwestern
cotton production,. Two general categories of work
efforts are involved. Type I tasks are economic
impact analyses for specific regulatory actions.
Type II tasks are baseline benefit/cost analyses
of pest management in western U.S. cotton produc-
tion .
(Chemical; Pesticides)
This work assignment will provide a survey of
current literature on the economic aspects of the
demand and supply of diesal engines. This will
enhance understanding of the potential impacts of
the regulations currently in place and any
alternatives which may be considered.
{Chemical_t Diesal particulates)
(Media: Mr)
Economic Analysis of
Environmental Programs for
Water Quality Standards
OWRS/Office of Analysis and
Evaluation
This new contract will provide for the development
of cost/benefit analyses of water quality
standards. The cost-effectiveness of the impacts
of waste load allocations will also be analyzed.
(Medias Water)
Economic Analysis of the
Chemicals Industry
OWRS/Office of Analysis and
Evaluation
This Project will support economic analysis of
effluent guidelines for the chemicals industry.
(Industry; Chemical Manufacturing)
(Media: Water)
26
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ECONOMIC STUDIES
Title
Office/Division
Description
Marine Estuary Cross
Industry and Multimedia
Economic Analysis
OWRS/Office of Analysis and
Evaluation
This project will focus on the 129 priority
pollutants agreed to by the Natural Resources
Defence Council/EPA consent decree. EPA is
required, as part of its role, to assess the
economic impacts of environmental regulations on a
diverse number of Clean Water Acts programs.
These areas include, Estuary and Marine Programs,
Effluent Guidelines, the dredge and fill programs,
National Urban Runoff Program (NURP), and other
nonpoint source control programs, and the various
sludge removal programs.
This contract will provide review of the current
methodologies presently in use to assess the
economic impacts and develop, as needed, more
efficient and versatile methodologies which will
aid in the Agency's mandated responsibilities of
assessing economic impacts on the national, state,
regional and local level.
(Media: Water)
Economic Analysis of
Environmental Programs for
the Energy and Natural
Products Industries
OWRS/Office of Analysis and
Evaluation
This contract will analyze ' economic impacts
resulting from the cost of regulating energy and
natural products industries. A cost and benefit
analysis will be perfomed to support permitting
programs for point sources. In addition, the
economic impacts of effluent limitations will be
studied .
(Industries_; Energy, Natural Products)
(Media: Water)
27
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ECONOMIC STUDIES
Title
Of fie e/pi vision
Description
Economic Analysis of
Environmental Programs for
the Metals Industries
OWRS/Office of Analysis and
Evaluation
This contract will analyze economic impacts for
metals/metal working industries with respect to
implementing certain provisions of the Clean Water
Act.
(Industries _;
Metal Industry
Aluminum Forming
Battery Manufacturing
Oil Coating
Mechanical Products
Nonferrous Metals
(Media: Water)
Electronic Components
Ferroalloys
Foundries
Iron and Steel
Metal Finishing
Porcelain Enameling)
Cost/Benefits Analyses
OPP/Benefits and Use Division
These cooperative agreements are conducting
economic analyses of pesticide regulatory
decision-making for use in registration standards,
special review and emergency actions.
(Chemical; Pesticides)
28
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TREATMENT TECHNOLOGY DE¥ELOPMENT/EVALUATION
Title
Of fice/Pivision
Description
Methods Development and
Water Pollution Control
Analysis
Cooperative agreement
The purposes of this project are (1) to determine
the 'feasibility and validity of using equations
for one area to estimate benefits for another
area; (2). to improve the methodology and
demonstrate more efficient approach to estimates
of national benefits from improved water quality.
(Media: Water)
Removal of Contaminants
from Drinking Water by the
Reverse Osmosis Treatment
Method
Cooperative Agreement
This project will evaluate the removal of inor-
ganic contaminants listed in National Interim Pri-
mary Drinking Water Regulation from drinking water
by reverse osmosis. Cost information on small
reverse osmosis systems will also be developed.
(Chemical_; Inorganics)
(Media: -Drinking Water)
Fourth International
Conference - Chemistry for
Environmental Protection
Cooperative Agreement
The proceedings of this -conference will present
the state-of-the-art on application of chemical
methods for environmental protection and identify
present and future trends in research and develop-
ment of water and wastewater treatment.
(Media: Water)
29
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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title Office/Division
Description
Treatment of Drinking
Water
Office of Drinking Water
This project will prepare treatment and costs
documents as well as method/monitoring documents
for revised regulations for microbials and
organics.
(Chemical; Organic chemicals)
A Review and Evaluation of
the Influence of Chemicals
on the Permeability of
Soil Clay
Cooperative Agreement
This cooperative agreement will provide laboratory
and field evaluation of the effects of selected
organic solvents on clay soil permeability* The
laboratory will complete the evaluation of effects
of concentration, hydraulic head, single and com-
bined mixtures of a variety of clay soils. Field
lysimeters, evaluating two "real world" wastes of
four soils, will be completed.
(Chemical; Solvents)
(Media:Land)
Scientific Basis for the
Selection of Polymers for
Water Treatment
Cooperative Agreement
This research will center on particle-polymer
interactions via polymer molecular weight, charge
density, flocculated particle size distribution,
and polymer mixing energies to derive a rational
method of polymer selection for water treatment.
(Media: Water)
Investigation and Analysis
of Organic Material
Accumulated from Drinking
Water by Activated Carbon
Filters
Assistance Amendment
The purpose of this project is to provide data on
carbon removal of contaminants from drinking
water.
(Chemical; Organic chemicals)
(Media: Drinking water)
30
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TKHMOLOGY DEVELOPMENT/EVALUATION
"Title
Office/Division
Description
Pilot Scale "Evaluation of
the Ozone/UV Process for
Removal of THM Precursors
Cooperative Agreement
This cooperative agreement will provide a pilot
'scale evaluation of the ozone/ultraviolet radia-
tion treatment process for the destruction of
trihalomethane precursors in drinking water.
Laboratory scale - studies will precede the pilot
scale work.
(Chemical_; Trihalome thanes)
(Media: Drinking Water)
Genetic Studies on a New
Anaerobe from Disgester
Sludge
Grant
This work will determine if degradation is caused
by a curable and transmissable plasmid, then
compare it to related strains, and characterize
mutants defective in the pathway. The ability to
metabolize aromatic ring structures will also be
s tudi ed.
(Chemica 1_; Aromatics)
(Media: Water)
Removal of Organic and
Inorganic Constituents
from a Contaminated
Drinking Water Source
Assistance Amendment
This project will provide a pilot plant evaluation
of alternative treatment techniques for removal of
ammonia and various specific organics including
trihalomethane* The best treatment technique
identified will be used to optimize the operations
of the Thornton (Thornton, CO) water plant to meet
existing regulations.
(Chemicals t Ammonia, Organic chemicals,
Trihalomethanes)
(Media: Drinking water)
31
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Title
Of fice/Di yijtig 11
Description
Workshop on Low—Cost
Wastewater Treatment
Processes
Cooperative Agreement
The purpose of this cooperative agreement is to
assemble engineering and regulatory personnel for
discussion of low-cost, low-energy processes for
achieving water 'quality objectives» Latest
research, design, and operational data on
mechanically simple treatment systems will be
disseminated to achieve a . variety of effluent
limitations*
(Media: Water)
THM Precursor Removal by
the Magnesium Process
Assistance Amendment
This project will provide a bench and small pilot-
scale investigation of methods to reduce the con-
centrations of trihalomethanes in the finished
water of a drinking water treatment plant using
the magnesium carbonate (mag-carb) process.
Process removals of heavy metals and heavy metal
and organic additions from recycled lime and mag-
nesium will also be investigated.
{Chemica 1_; Trihalome thanes, Heavy metals)
(Media_: Drinking water)
US/USSR Prevention of
Water Pollution from •
Industrial/Municipal
Sources
Cooperative Agreement
This project will provide administrative and
logistical support for a conferencei of US/USSR
scientists to exchange new developments and
technologies in. • the area of municipal and
wastewater pollution control and prevention.
(Media: Water)
32
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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Ti tie Of fice/Di vision
Description
Management of High
Strength Spills Wastes and
Dump or Landfill Leachates
Assistance Amendment
In this project, high strength wastes will be
separated for treatment by physical/chemical and
biological methods.
(Media: Land)
Land Treatment Research
Project
Assistance Amendment
The acquisition and preparation of a pilot-scale
land treatment site? collection? application,
sampling of OSW-specif ied wastes! operation of
column studies; management of field plots;
lysimeter operations! loading rate optimization!
closure-postclosure operations. Technical assis-
tance studies for ORD, OSW, States and industries
and verifiable basic and applied research studies
will be conducted»
(Media: Land)
33
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WASTE MANAGEMENT/RESOURCE RECOVERY
Title. Office/Division
Description
Site Selection for Land
Treatment
Cooperative Agreement
This cooperative agreement will provide a
methodology, in document form, for selecting
appropriate sites for land treatment of solid and
hazardous wastes and identify those charac-
teristics which can be managed and operated for
acceptable performances as a system.
(Chemical; Hazardous wastes)
(Media: Land)
Second Biennial
International Symposium on
Industrial and Hazardous
Was tes
Cooperative Agreement
This cooperative agreement will provide for the
development and presentation of a Conference for
exchanging information among scientists,
engineers, governments, and policy makers on
hazardous wastes. Topics will include: (1) new
methodology for monitoring, analysis of air, soil
and groundwater; (2) state-of-the-art of treatment
and control technology and (3) management and
institutional procedures to reduce costs and
improve efficiency.
(Chemical: Hazardous wastes)
(Media; Air, Land, Groundwater)
Investigation of Failure
Mechanisms and Migration
of Industrial Chemicals at
Wilsonville, Illinois
Cooperative Agreement
This project will study the Wilsonville, Illinois
hazardous waste landfill to determine why organic
contaminants are, leaching into soils surrounding
the site.
(Chemical; Organic Chemicals)
(Media: Land)
34
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WASTE MANAGEMENT/RESOURCE RECOVERY
Ti tie Of fice/Pivision
De s c r i p t ig n
Evaluation and Control of
Potential Health or
Environmental Problems
Associated with Used Oil
Recycling or Disopsal
OSW/Hazardous and Industrial
Waste Division
See: Health/Environmental Effects
Kinetics of Microbial
Degradation of Hazardous
Wastes by Land Treatment
Grant Agreement
This project entails the development of predictive
model(s) for fates of given organic waste
constituents under soil and climate conditions
during land treatment of hazardous wastes„
Microbial soil reactors will be used for
developing biodegradation kinetics. These kinetic
data will be used for developing the predictive
model»
(Chemical; Hazardous wastes)
(Media: Land)
Cooperative Agreement for
the Industrial Waste
Elimination Research
Center
Cooperative Agreement
The center will perform long-term exploratory
research to address technology associated with the
control of environmental pollutants.
Sampling and Analysis
Incident to Destruction of
Polychlorinated Biphenyls
(PCBs)
OWRS/Criteria and Standards
Division
This work assignment will provide for the
continued analysis of various samples taken during
the incineration of toxic waste materials at sea.
(Chemical: Polychlorinated biphenyls)
35
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WA_S TE_ MAMAGEM E_NT/RESOORCE^ JlEg WERY_
_TJL_tle_ Office/Di yisign
Description
Environmental
Characterization of the
Disposal of Waste Oils and
Other Hazardous Waste in
Combustors and Using
Alternative Types of
Pollution Control Methods
OSW/Hazardous and Indus trial
Waste Division
This task will characterize emissions from
boilers/combustors burning waste oil and other
types of hazardous wastes as fuels or supple-
mentary fuels. The destruction and removal
efficiency of various constituents will also be
specified *
(Chemical_i Waste oil, Hazardous wastes)
(Media: Air)
Supplemental Support to
Waste as Energy
Notification and Analysis
OPRM/Office of Policy Analysis
The work assignment will provide support services
waste-as-energy notifications which regulate the
use of boilers as hazardous wastes incinerators
and control all hazardous waste burnt as fuel for
energy recovery in all devices. This will
include:'
o Determining impacted segments and potential
notifiers.
o Identifying data elements (economic,
demographic, and policy) to characterize
highly impacted segments
(Chemical: Hazardous wastes)
36
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WASTE MANAGEMENT/RESOURCE RECOVERY
Title Office/Division
De s c ri p t io n
Seismic and Floodplain
Regulatory Impact Analysis
OPRM/Office of Policy Analysis
This work assignment will provide a series of
documents which address the hazards associated
with the location of hazardous waste facilities in
seismically sensitive areas. This will include
the folowing efforts:
o Identifying and defining the human health and
environmental risks which exist as a result
of locating waste containment facilities in
seismically sensitive areas.
o Determine the adequacy of existing industry
practices, governmental standards and private
control mechanisms.
o Identify the mitigative practices which
reduce the risk of damage to facilities and
lessen possible health risks associated with
the release of materials to the environment.
(Chemical: Hazardous wastes)
Silvex Disposal
OPP/Program Support Division
This contract will provide for the disposal of
liguid silvex stores in fulfillment of Agency
statutory responsibilities
(Chemical: Silvex)
37
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POLICY STODIB S/REGULATORY CONTROLOPTIONS
Title . Office/Division
Description
Benefits Literature Review OPRM/Office of Policy Analysis
This work assignment will provide for the review-
ing, critiquing and cataloguing of benefit esti-
mation literature in the fields of air, water and
hazardous wastes.
(Medias Mr, Water)
State Integrated Toxics
Management Technical
Information Program
OPTS/Chemical Coordination Staff
The purpose of this grant is to facilitate the
exchange of information and expertise among state
executive branch agencies concerned with the
environment and human health. In addition, the
institutionalization of integrated toxics manage-
ment in the states will be encouraged.
State Legislative
Initiatives and Trends in
Toxic Substances
Management
OPTS/Chemical Coordination Staff
See: Health and Environmental Effects
States FIFRA Issues
Research and Evaluation
Group
Assistance Amendment
This project will utilize the Association of
American Pesticide Control Officials (AAPCO) to
provide information and recommendations
regarding the impact of Agency plans on State
regulatory programs and to develop' s'trategies for
implemention of key provisions of the amended
Federal Insecticide, Fungicide and Rodenticide Act
{FIFRA).
38
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Title
Of f ice /Pi yi sio n
Description
Effluent Guidelines
Support
OWRS/Effluent Guidelines Division
The following contracts support the development of
effluent guidelines limitations:
o Basic water quality analyses for all indus-
trial categories. This includes• projections
of water quality impacts under the regulatory
options for each industry.
o Maintain and make improvements in the indus-
trial discharger computer files which are
used in- water quality assessments.
o Comprehensive background water quality infor-
mation on stream segments affected by indus-
tries of particular concern including those
of which regulatory impact analyses have been
performed.
o Sophisticated water quality modeling
expertise for a detailed analyses of water
quality impacts.
o Projections of effluent loading of a large
number of priority pollutants from individual
facilities in the organic chemicals industry.
(Media: Water)
39
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PO_MC_Y _STODIES/REGUIATORY CONTROL OPTIONS
Ti_tle_ . Of f ice/Pi vision
Description
Effluent Guidelines
Support (continued)
OWRS/Effluent Guidelines Division
o Analysis of data on ambient water quality
data and environmental fate and effects
information on toxic pollutants. Comprehen-
sive site specific information on water
quality to be used in develop!ng waste load
allocation guidance for toxic pollutants.
o Provide computerized ability to identify
pollutants not on the priority pollutant list
by screening GC-MS tapes that -are generated
from the analysis of ambient water samples. •
(Industry; Organic chemical manufacturers)
(Media: Water)
Scientific and Laboratory
Support for Ocean Survey
Program
OWRS/Criteria and Standards
Division
This developing contract will collect and
efficiently utilize marine and environmental data
to assess^ the past impacts of the disposal of
pollutants in the ocean. This will assure that
present and future ocean disposal practices do not
unreasonably degrade the ocean. Appropriate ocean
disposal sites and critical areas will be
designated.
(Media: Water)
Pollutant-by-Pollutant
Toxics Controls
OWRS/Monitoring and Data Support
Division
The intent of this contract modification is to
provide general guidance design conditions,
workshops and guidance on probabilistic controls
for discharges of toxic pollutants into rivers and
s tr earns.
(Media: Water)
40
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POLICY STOPjE_S/RBG_yiATQRY CONTROL OPTIONS
Ti_tle_ Office/Division
Description
Complex Effluent Toxicity
Testing Program
Office of Water Enforcement/
Permits Division
This contract modification will provide on-site
biological assessments of National Pollutant
Discharge Elimination System (NPDES) permit
discarges. On-site research will be provided to
support the development of toxicity analyses and
abatement procedures in;the NPDES permit program.
(Medias Water)
Enforcement of Regulations
for Pesticide Materials
and Formulations
GPP/Benefits and Use Division
This cooperative agreement will develop, with the
Association of Official Analytical Chemists
(AOAC), supportive means to validate and publish
analytical methodology to enforce regulations
pertaining to pesticide materials and
formulations.
(Chemical: Pesticides)
Pesticide Usage Survey
OPP/Benefits and Use Division
This new contract will collect information on
various non-agricultural pesticide application
sites to assist in the development of economic and
regulatory impacts.
(Chemical: Pesticides)
41
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Chemical Analyses
Ti tie
Of fice/_Piyi_s_io.n
Des_cript:ion_
S trueture-Reactivi ty
Relationships for
Predicting Environmentally
Hazardous Chemicals
Cooperative Agreement
The purpose of this cooperative agreement is to
develop accurate methods of estimating gas phase
reaction rate constants for predicting the
atmospheric lifetimes of any potentially toxic
substance present in the atmosphere with molecules
and radicals found in the atmosphere which can
react with the chemical substance.
(Mediai Air) •
Validating Rapid Methods
of Partition Coefficient
Determination.
Cooperative Agreement
The objectives of this project are to critique the
logic used to compute the n-octanol/water parti-
tion coefficient -(Log P) for industrial chemicals?
provide measurements of Log P for chemicals never
before studied, and develop a new computer program
which provides more accurate estimates of Log P:
for PMN chemicals.
42
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METHODOLOGY DEVELOPMENT
Treatment Processes and Monitoring
Ti tie Of fice/Pivision
Description
Downhole Sensing Methods
for Hazardous Waste Site
Monitoring
Cooperative Agreement
This cooperative agreement will provide testing
and evaluation of downhole sensing equipment and
techniques for hazardous waste monitoring and
detection using small diameter shallow boreholes.
(Chemical: Hazardous wastes)
(Media: Land)
Application of Non-
Destructive Testing (NDT)
to Locate and Determine
the Dispersion in Soils of
Hazardous Materials,
Wastes, and Leachates from
Spill and Release
Incidents
Assistance Amendment
A comprehensive survey of 18 NDT methods is
underway to assess applicability to various actual
or potential release situations. Electromagnetic,
acoustic, and geophysical approaches are being
adapted .
(Chemical: Hazardous materials and wastes)
(Media: Land)
A Study of Possible
Economical Ways of
Removing Radium from
Drinking Water
Cooperative Agreement
This study will determine if and how iron removal
units alone could provide the required economical
radium reduction process that many small community
water supplies are currently seeking.
(Chemical; Rad i u m)
(Media: Drinking water)
43
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METHODOLOGY DEVELOPMENT/VALIDATION
Health and Environmental Studies
Ti tie Of f ice/Pi, vision
Analysis of Environmental
Mixtures by Short-term
Bioassayss Quality
Assurance for Biological
Testing
Cooperative Agreement
Using the Natural
Detoxification Capacities
of Organisms to Access the
Environmental Impact of
Contaminants
Grant
A Rapid Sensitive and
Inexpensive i_n vi_vo_
Carcinogenesis Tests
Assistance Amendment
Des c ri p t io n
The purpose of this cooperative agreement is to
support evaluation of mutagenicity testing proce-
dures and samples preparation procedures; and
develop an audit sample program.
The purpose of this grant is to refine, expand and
standarize developed methods for toxicity bioassay
in marine organisms.,
This project will develop a relatively rapid,
simple and inexpensive in vivo carcinogen screen-
ing test for chemicals.
44
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METHOPOLOG Y DEVELOPMENT/yftLIDATION
Health and Environmental Studies
Title Office/Division
Description
Use of Receptor Studies
for Toxic Source
Apportionment
OAQPS/Monitoring Data Analysis
Division
The purpose of this contract is to examine the
feasibility of using source apportionment methods
that have been successfully applied to relate
particulate emissions to particulate matter air
quality contributions with a number of potentially
toxic substances«
(Media: Air)
Statistical Evaluation of
Test Designs Data
Requirements and
Analytical Procedures
Utilized by the Office of
Toxic Substances
Cooperative Agreement
This project will determine
designs for test • standards
experiments, determine data
collection of an adequates
ap pr opr i a te tes t
and round-robin
requirements for
quali ty-assured,
aquatic toxicology data base, and evaluate and
interpret data that are submitted to the Office of
Toxic Substances.
45
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STATISTICAL ANALYSES
Title
Of fice/pivision
Description
Statistical Methodology
for Industrial
Environmental Research
Cooperative Agreement
The purpose of this project is to provide an
avenue for the direct input of professional
statistical theory and practice in the areas of
direct liquefaction studies, synfuel combustion
studies, volatile organic compound emission
assessment, precision/accuracy of updated
analytical procedures and hazard assessment of new
industrial technologies.
(Chemical; Volatile organic chemicals, synfuels)
Aquatic Life Survey
OWRS/Monitoring and Data Support
Division
This .project will provide assistance in an aquatic
life survey and other statistical approaches for
the overall assessment of water quality,
(Media: Water)
Statistical Analysis
OWRS/Office of Analysis and
Evaluation
This new contract will provide a statistical
analysis to support the development of effluent
guidelines limitations and management of a data
base.
(Media: Water)
46
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STATISTICAL ANALYSES
Title
Office/Division
Description
Statistical Analysis and
Computerized integration
of Structure-Activity
Relationships for
Industrial Chemicals
Cooperative Agreement
The objectives of this project are to define and
analyze a chemical similarity index for about
20*000 industrial chemicals and design and analyze
a classification program to identify the
degradability of 400-600 industrial chemicals
using the 134 molecular connectivity indices.
(Chemical: Industrial chemicals)
Statistical Analysis of
Data from the Pesticide
Registration Process
OPP/Program Management and
Support Division
This new contract will provide planning and
analysis support to evaluate and develop
management information, control methods and data
for use in program planning and management.
(Chemical: Pesticides)
47
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MODELING
Title
Of f i ce/ Pi vi s ion
Description
Assessment of Mr Quality
Models and Their
Application
Assistance Amendment
This project will investigate and evaluate Mr
Quality Models that are related to standards and
regulations of ambient concentrations of
particles.
(Media: Mr)
Development and
Application of an Advanced
Utility Simulation Model
Cooperative Agreement
Researchers on several university campuses will
provide expertise and technical support in the
development of an advanced utility simulation
model for use in regulatory policy analysis.
Modeling Observed
Hydrocarbon Mixture
Reactivity Effects
Grant
The dual outdoor chamber of the University of
North Carolina will be used to study the, effects
of altered hydrocarbon mixture composition on the
products of photochemical smog in urban" _areas.
Tests of several airshed models will be made using
the outdoor chamber data to help establish more
realistic urban airshed models.
(Chemical: Hydrocarbons)
(Media: Mr)
48
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MODELING
Title
Description
Improvements in Ammonia
Modeling
Office of Water Enforcement/
Permits Division
This contract will provide improvements to QUAL II
and the State of Iowa's model and tested on Iow:a
rivers. This project is part of the Water Bodies
Modeling Program which studies the fate and
effects of water pollutants.
(Chemical: Ammonia)
(Media: Wa ter)
49
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DATA DEVELOPMEHT ' ' - -
Ti tie Of f i ce/Pi vision Description
On-Line Access to the DARC OTS/Management Support Division The purpose of this system is to provide full
Substructure Search System substructure search capabilities, "Biese
capabilities include the ability to retrieve
specific chemicals and substructure search to
retrieve a family of compounds with a desired
structural feature
On-Line Access to Various OTS/Management Support -Division ' The following data bases are supported by various
Data Bases interagency agreements to provide on-line access:
o Dialog Information Services: 250 data bases
containing chemical, agricultural, bio-
medical, environmental scientific and
business information.
o On-line Retrieval of Bibliographic
Information, Time-Shared (ORBIT): 68 data
bases containing environmental, energy,
chemical and health data.
o Bibliographic Retrieval Service Data Base:
47 data bases containing bibliographical
health, environmental, economic, management
and library science information.
o National Library of Medicine Data bases: 16
data bases containing chemical or biomedical
data.
o BIOMBD Data Base (Institute of Scientific
Information): Contains primary journal
information in all biomedical diciplines.
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SAMPLING ANALYSIS AND MONITORING
Chemical Analyses—Specific Topics
Title Office/Division
Description
Mutagens from Non-Volatile
Organics in Drinking water
Cooperative Agreement
This project will employ a coupled bacterial
mu-tagenesis assay/reverse phase HPLC subfrac-
tionation procedure, to isolate mutagens found in
drinking water residue organics for further
biological characterization and compounds
identification.
(Chemical: Nonvolatile organics)
(Media: Drinking Water)
Laboratory Support
Services for Effluent
Guidelines
OWRS/Effluent Guidelines Division
This contract modification will provide
demonstrated analytical instruments and techniques
to identify and measure the volatile and semi-
volatile organic compounds in a variety of water
and wastewater samples. Analyses to be performed
include extraction and concentration procedures,
and acceptable gas-chromatographic (GC) and
mass spectrometric (MS) procedures. These
activities will identify and estimate the
concentration of organic compounds in samples
collected across the U.S. A quality
assurance/quality control program will also be
executed under this contract. This project will
support the Effluent Guidelines Division Sampling
and Analysis Program.
(Chemical: Volatile organic compounds,
Semi-volatile organic compounds)
(Media: Water)
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SAMgLITJG &NM.YSIS AND MONITORING
Chemical Analyses—Specific Topics
Ti tle Offi ce/Division
Description
Smog Chamber Study of
Aromatic VOC's and Their
Oxidation Products
Cooperative Agreement
The purpose of "this project is to obtain detailed
information on the kinetics- and mechanism of aro-
matic hyirocarbons under carefully -con trolled
photo-chemical smog conditions.
Aromatic hydrocarbons)
Air)
_
(Media:
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SAMPLING ANALYSIS AND MONITORING
Environmental Monitoring
Title
Office/Division
Description
Environmental Monitoring--
Research and Development
Cooperative Agreement
This cooperative agreement' will provide for the
development of enhanced monitoring instrumentation
and techniques, statistical methods for applica-
tion to design of monitoring strategies and data
interpretation insuring the most efficient and
cost effective programs.
Environmental Monitoring
and Assessment of
Pollution Impact on
Ecosystems• .
Assistance Amendment
The purpose of this assistance amendment is to
investigate the environmental and health1 hazards
associated with specific activities and pollutants
in aquatic ecosystems and to develop and test
environmental monitoring techniques.
(Media: Water)
Network design and Site
Exposure Criteria for
Selected Non-Criteria
Pollutants
OAQPS/Monitoring Data Analysis
Division
This effort will provide a guidance document for
ambient air monitoring network design and siting
for toxic organic compounds. The guideline will
include the following: monitoring objectives,
data needs and principal uses of data; pollutant
characeristies that need to be considered in
network design; spatial scale of representa-
tiveness and siting procedure for locating each of
the representative types of monitoring sites;
specific siting criteria and siting rationale
based on past monitoring studies^ modeling and
practical consideration.
(Chemi ca 1: Toxic organic chemicals)
(Media: Air)
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SAMPLING ANALYSIS AND MONITORING
Environmental Monitoring
Ti tie
Office/Division
Description
Support in Determining
Water Quality Criteria
OWRS/Criteria and Standards
Division
The intent of this contract .modification is to
acquire field data for fresh and marine waters.
This will include data collection for ocean
disposal site designation and data collection and
analylsis for site-specific •criteria on fresh
wate r.
(Media: Water)
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IMDBC
Ctieaicals
Acetaldehyde (75-07-0)
ammonia (T664-41-7)
Aromatics
Arsenic compounds (7440-38-2)
Asbestos (1332-21-4)
3H-Benzo(a)pyrene (50-32-8)
C.I. Disperse Yellow 3 (2832-40-8)
Cadmium (7440-43-9)
Carbon tetrachloride (56-23-5)
Chlorinated hydrocarbons (SEQ:11)
p-chlorobenzotrichloride (1344-32-7)
1-Chloro-2-nitrobenzene (88-73-35
1-Chloro-4-nitrobenzene (100-00-5)
Coke oven emissions (SEQ:3)
Copper (7440-50-8)
DSC Red No. 9 (5160-02-1)
DEHP (117-81-7)
2,4-diaminoazobenzene
2,3-dichlorodioxane (95-59-0)
Dichloromethane (75-09-2)
Diesel fuel emissions (SEQ:110)
Diesel particulates (SEQ:110)
Difurcxanthone-type alkylating agents
7,12-dimethylbenz(a)anthracene) (57-97-6)
Disinfectants
2,2,-Dithiobis (benzothiazole) (120-78-5)
Endothal (145-73-3)
Ethoxyethanol (110-80-5)
Ethoxyeth'anol acetate (111-15-9)
Ethylnitrosourea (759-73-9)
Fenthion (55-38-9)
Formaldehyde (50-00-0)
Hazardous chemicals
Hazardous materials
Hazardous wastes
Heavy metals (SEQ:73)
Page
21
31,
52
49
31,
11
19
5
21
14
4
4
21
21
21
3
14
21
19
21
21
19
8
26
9
5
4, 13
21
4
19
19
11
16
4, 19
5
43
13, 15,
14, 17,
34,
43
35, 36, 37, 43
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CfaewLcals CContinued)
Page
Hepatotoxins containing anthraquinone nucleus (84-65-1)
1,2,3,4,7,7-Hexachloronorbornadien (2550-75-6)
jHumic acids (1415-93-6)
Hydrocarbons (SEQs 11)
Industrial chemicals
Inorganics
iso-Butanol (71-36-3)
Lead (7439-92-1)
Lipid chemicals
MBOC& Methylene bis(o-chloroaniline) (101-14-4)
Melamine (108-78-1)
Me thoxyethanol (109-86-4)
Methoxyethanol acetate (110-49-6-)
Methylnitrosourea (684-93-5)
NTS .
Haled (300-76-5)
Nitrosamine congener alkylazoxymethanol type alkylating agents
Nonvolatile organics
Organic chemicals
Organochlorines
Pentachloroethane (76-01-7)
Pentachlorophenol (87-86-5)
Pesticides
Photochemical oxidants (SBQ:79)
Polychlorinated biphenyls (13336-36-3)
Polyhalogenated biphenyls and related aromatics
Polynuclear _lactone alkylating agents
n-Propanol (71-23-8)
Radium (7440-14-4)
Semi-volatile organic compounds
Silvex (32534-95-5)
Solvents.
Sulfur Dioxide (7446-09-5)
Synfuels
Tannins (T401-55-4) and flavonoids
14
9
21
4
48
47
29
21
8,
9
19
21
19
19
11
19
16
9
51
6,
7
21
15
16, 18, 25, 28, 41, 47, 75
25
19, 35
9, 35
9
21
43
51
37
30
25
15, 46
9
13, 16, 17, 30, 31, 34
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Q*e«ieals (Continued) Page
Tetrabromoethane (573-58-0) . 21
Tetrachloroethene (127-18-4) 1 9
Tetrachloromethane (56-23-5) 19 .
Toxic organic chemicals 1? 53
1,1,1-Trichloroethane (71-55-6) 19
Trichloroethene (79-01-6) 19
Trichlorotrifluormethane (76-13-1) 19
Trihalomethanes (SBQ:28) 31, 32
Trimethyltin (594-27-4) 6
Vermiculite (1318-00-9) 19
Volatile organic compounds ' 46, 51
Waste oil 2, 36
Page
Adhesives and sealants 24
Aluminum forming 24, 28
Battery manufacturing 23, 28
Chemical manufacturing 23, 26
Coil coating 23
Copper forming 24
Electrical and electronic component 23
Electronic components 28
Electroplating 23
Energy 23, 24, 27
Ferroalloys 28
Food 24
Foundries 28
Gum and wood chemicals 24
Inorganic chemical manufacturing 24
Iron and steel 28
Leather 24
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J&icfes s tries C Cbntinned)
Page
Mechanical products
Metal finishing industries
Metal industries
Metal molding and casing (foundry) industries
Mill finishing
Mining
Natural products
Nonferrous metals manufacturing and forming
Oil coating
Organic chemical manufacturing
Paint and ink
Pesticides
Pharmaceuticals
Photographic processes and equipment supplies
Plastics
Plastic molding and forming industries
Porcelain - enameling
Printing and ink
Printing and publishing
Pulp and paper
Rubbers
Soaps and detergents manufacturing
Textile
Timber
Wood industries
28
23, 28
28
24
23
24
27
24, 28
28
24, 28, 40
24
24, 41
24
23
24
23
23. 28
24
24
24
24
24
24
24
24
Media
Air
Page
1, 3, 5, 7, 8, 18,
19,' 20, 25, 26, 34, 36,
38, 42, 45, 48, 52, 53
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Media (continued)
Drinking water 4, 6, 7, 9, 11, 19,
20, 29, 30, 31, 32,
43,.51
Groundwater 34
land 2, 13, 17, 19, 30
33, 34, 35, 43
Sediments 17
Water 1, 13, 14, 15, 16
17 19, 22, 24, 26
27 28, 29, 30, 31
32,38, 39, 40, 41
46, 49, 51, 53, 54
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