Etwifonitwntsi Protection
                       A§eney •   ...
Office of ToKle
Washington,. CSC.       .-.'.::
EPA 950-R-84-004

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                                      Acknowledgement:









The Chemical  Coordination Staff of  the Office of Toxic  Substances  wishes  to express its




appreciation to the EPA project managers, contract officers, and program budget officials,




the Grants  Administration  Division  and  the  office of  Research Grants and  Centers, who




assisted in the  development of this  document by providing contract and grant information




and the  timely  review of  draft  descriptions.   Without  their  enthusiastic  cooperation,




production of this document would not have been possible.
                                                  Walter W. Kovalick, Jr.
If you  have any questions or  comments concerning the EAR,  or  wish to receive additional




copies please contact  Joanne LaBaw (382-3395) or Arnie Edleman  (382-2249) of the Chemical




Coordination Staff.

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                                           TABLE OF CONTENTS









Fate and Transport/Materials  Balances,.......................,«,-;....,....»».»...	t	   1




Health/Enviroflitental ^Effects.*	.»..,....	...................»,»..,... „ ..,»..,».,,..»,,«»...   5




Health Effects......,, .'.	..	...................V	   8




EnviroatBental  Effects,...",..... .''j,-*,	.».'.»«,...:......,..-,..,',...,................,...   18




Exposure.........^[[[   23




Risk.	.,,	   27




Industrial Studies	   30




Economic Studies	   31




Treatment Technology  Development/Evaluation	   36'




Waste Management/Resource Recovery	   42




Emergency Response	   48




Policy Studies/Regulatory and Control Options	   49




Methodology  Development/Validation	-	   55




Modeling	   58




Data  Base Development	   60




Sampling, Analysis and Monitoring	   61




    o   General.	   61





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                                        .  .                                           	  68
Conferences, Symposia, Workshops and Training	

                                                                        	  70
Statistical Studies	

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        UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

                    WASHINGTON, D.C.  2046O
MEMORANDUM
SUBJECT:
          Agency Extramural Activity Report  (EAR)  for
          Toxics-Related Projects, Volume  III,  Issue 1
FROM:
Messner
          Howard M .
          Assistant
         U  for Administration
        /^Resources Management /

          John A. Moore, D.V.M.   Y''
          Assistant Administratorjfy
           for Pesticides
           and Toxic Substances

          Assistant Administrators
          AA Budget Officers
          Regional Administrators

     Volume III, issue 1 of the  Extramural Activity  Report
(EAR), prepared by the Chemical  Coord ination~sFa"ff "(CCS)" "of
the Office of Toxic Substances is attached.   It  includes
descriptions of toxics-related projects being developed
under contract as well as grants, cooperative agreements or
assistance agreements awarded since August 1983.

     To facilitate use of the EAR, the projects  have been
indexed, where possible, by chemical,  industry and environ-
mental medium.  These indices are listed at the  end of the
document.  In addition, the EPA  project officers' names  and
phone numbers are included so that you can call  them directly
if you are interested in a specific project.

     As you know, the EAR is developed in consultation with  the
particular programs involved with each project.   The primary
purpose of the EAR is to aid in  the planning  and  development
of extramural efforts by providing a  source of information
                              -2-

as to which extramural projects are currently being developed
or ongoing throughout the Agency.  By coordinating these
efforts, their quality and consistency can be improved and
extramural duplication can be avoided.  We strongly encourage
you to use the EAR as a tool in the procurement process.

     As an EAR user, we thought you might be interested in
the results of the recent survey contained in the August 1983:
issue of the EAR.  CCS received approximately 200 responses
from EPA Headquarters, regions, laboratories, as well as
other recipients not directly affiliated with .EPA (i.e., othe
Federal and state agencies).  The surveys received represent
approximately half of those who receive the EAR and, therefor-
give a good indication of how the EAR has been utilized.

     According to this survey, the EAR has saved its users
approximately $262,000 and  1.2 work-years.  The vast majority
of the  responses  (about  75%)  indicate that the EAR  has  been
used to  identify research activities of  interest or as  a
reference  tool.   Forty-five percent  indicate  that  the EAR
has aided  in avoiding duplication of efforts, and sixteen
percent  utilize  the  EAR  in  the initiation of  extramural
efforts, either  through  "adding-on"  to existing contracts,
or through the joint development of  projects.

Attachment
                                                          cc:
      Office  Directors
      Division  Directors

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FATE AND TRANSPORT/MATERIALS  BALANCES
Title
Of fice/Division
Description
Locating and Estimating
Air Bnissions from Sources
of Chlorobenzenes, PCBs?
Vinylidene Chloride,
Phosgene and Manganese
Gas Volatilization from
Disposal
Dioxin Studies
Office of Air Quality Planning
and Standards/Monitoring and Data
Analysis Division
Research Triangle Park, NC

Tom Lahre
8/629-5585
ORD/Municipal  Environmental
Research Laboratory
Ci nc inna ti, OH

Steve James
8/684-7871

ORD/Municipal  Environmental
Research Laboratory
Cincinnati, OH

Don Banning
8/684-7875
A  summary   report   will  be  prepared   for   each
substance  describing  the kinds  of  sources  that
emit  each  substance,  where  they are  located,  and
will  present emission  factors  for. estimating .air
emissions from these.

(Chemicals:  PCBs
             Chlorobenzenes
             Vinylidene chloride
             Manganese
             Phosgene)

This work assignment will provide an assessment of
gas   volatilization   for  the  land   disposal   of
hazardous wastes.

(Media:  Land, Air)
Two  studies   will  examine  the  potentials   for
intermedia   transport   that   result   from   the
contamination  of  soils  by  dioxins.   The  first,
which  is  currently underway,  will evaluate  these
soils  for  leachability*    The  second,  which  is
planned,  will evaluate  these  soils  for  fugitive'
dust emissions.
Environmental Fate
Office of Pesticide  Programs

Lionel Richardson
557-0269
(Chemical:  Dioxins)
(Media;  Land, Ground water, Air)

This contract will provide for the  preparation  of
topical   discussions   on   environmental    fate,
exposure  profiles  and  evaluations  of  data  and
individual studies.
                                                                       (Chemicals:   Pesticides)

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FATE AHD TRANSPORT/MATERIALS BMANCES
Title
Office/Division
 Description
Environmental Fate of
Natural and Synthetic
Organic Products
ORD/lnvironmental Research
Laboratory
Gulf Breeze,  FL

Parmerly Pritchard
8/686-9011
The   overall   objective   of   this   cooperative
agreement    is    to   determine   the   rates   of
biodegradation  for selected pollutants  in aquatic
•habitats and to elucidate the  factors  that affect
these rates  and mechanisms of biodegradation.

(Medium:  Water)
Statistical Analysis  and
Computerized  Integration
of Structure-activity
Relationships for
Industrial Chemicals
 Incorporation of
 Xenobiotic  Aromatic
 Compounds into Soil and
 Sediment Humus
ORD/Environmental  Research
Laboratory
Duluth,  MN

Oilman D. Veith
218/727-9534

Office of Research and.
Development

Louis Swaby
382-5741
 Analytical Chemical
 Support for Studies on the
 Pates  and Effects of Toxic
 Organic Compounds in the
 Marine Environment
 Environmental Research
 Laboratory/ORD
 Narragansett, RI

 Allan D. Beck
 8/838-4843
 The  objectives  of this assistance agreement are to
 define  and  analyze a chemical similarity index for
 about 20,000 industrial  chemicals and  design and
 analyze a  classification  program to  identify the
 degradability  of   400-600   industrial  chemicals
 using the 134 molecular connectivity  indices.

 Polymerization  of  xenobiotics  by fungal  enzymes
 will be studied in the laboratory and then natural
 samples,    This will  be extended to polymerization
 of xenobiotics with humus.   The results  will be
 useful  in  describing the fate  of these compounds
 in the  environment.

 {Medium;  Land)

 These  studies  will  include  chemical  analysis of
 selected    organic   compounds   present   in   field
 samples.    In addition, this  agreement will  allow
 collaboration  in  the  design,  implementation, and
 interpretation of  chemical  studies  on  the  fates
 and'  effects of  toxic  organic  compounds  in the
 marine  environment.
                                                                       (Mediumi  Water}

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FATE AND TRANSPORT/MATERIALS BALANCES
Title
Office/Division
Description
Environmental Fate of
Natural and Synthetic
Organic Products
Statistical Analysis  and
Computerized  Integration
of Structure-activity
Relationships for
Industrial Chemicals
 Incorporation of
 Xenobiotic  Aromatic
 Compounds into Soil and
 Sediment Humus
ORD/Environmental Research
Laboratory
Gulf Breeze,  FL

Parmerly Pritchard
8/686-9011
OKD/Environmental  Research
Laboratory
Duluth,  MH

Gilman D. Veith
218/727-9534

Office of Research and
Development

Louis Swaby
382-5741
The   overall   objective   of   this   cooperative
agreement   is   to   determine    the    rates   of
biodegradation  for  selected pollutants  in  aquatic
habitats and  to elucidate the factors  that  affect
these rates and mechanisms of biodegradation.

(Medium;  Water)

The objectives  of this  assistance agreement are to
define and analyze  a  chemical similarity index for
about  20,000  industrial  chemicals  and  design and
analyze  a  classification program to identify the
degradability   of   400-600   industrial  chemicals
using the 134 molecular connectivity indices.

Polymerization  of  xenobiotics  by   fungal  enzymes
will be  studied in  the  laboratory and  then  natural
samples.   This  will be extended  to  polymerization
of  xenobiotics  with  humus.   The results will be
useful  in  describing the fate of these compounds
in the environment,!

 (Medi urn:  Land)
 Analytical Chemical
 Support for Studies on the
 Fates  and Effects of Toxic
 Organic Compounds in the
 Marine Environment
 Environmental Research
 Laboratory/ORD
 Narragan.sett, R!

 Allan D.
 8/838-4843
These  studies  will include  chemical analysis  of
selected   organic  compounds   present  in   field
samples.   In  addition,  this agreement  will  allow
collaboration  in  the  design,  implementation,  and
interpretation of  chemical studies  on the  fates
and  effects  of  toxic  organic  compounds  in  the
marine environment.
                                                                       (Mediums  Water)

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FATE AND TRANSPORT/MATERIALS BALANCES
Title
Office/Division
Description
Stochastic Prediction of
Dispersive ~ Contaminant
Transport
Influence of Subsurface
Organic Matter Complexes
on the Transport and  Fate
of Organic Pollutants
Determination of  Effective
Porosity of  Soil  Materials
ORD/Environmental Research
Laboratory
Ada, OK

Joseph P. Keely
8/743-2011

ORD/Environmental Research
Laboratory
Ada, OK

Marvin Piwoni
8/743-2011

ORD/Municipal  Environmental
Research  Laboratory
Cincinnati,  OH

Walter E. Grube,  Jr.
8/684-7871
Evaluation   of   Stochastic   Models   to   assess
subsurface contaminant transport.

(Medium:  Ground water)
Distribution  of  soil inhomogeneities and  som  will
be determined under this cooperative agreement  in
the  context  of  the  effect  they  will  have  on
organic pollutant transport.

(Medium:  Ground water)

Morphometric  measurements of porosity will be  made
under  this  cooperative agreement  on  undisturbed
soil samples  from soil horizons  in  Iowa that  have
been  permeated with tracer  solutes»   Laboratory
hydraulic conductivity  and  other variables will be
correlated with the  experimentally  determined  pore
characteristic data*
Determination of
Subsurface  Contaminant
Transport Using Microcosm
Systems
national  Center  for  Ground
Water  Research
 ORD/Robert S.  Kerr Environmental
 Research  Laboratory
 Ada,  OK

 John  T, Wilson
 8/743-2011
 ORD/Robert S.  Kerr Environmental
 Research Laboratory
 Ada,  OK

 Richard Scalf
 8/743-2011
(Medium;  Land, Ground water)

The  objective  of   this  project  is  to  design,
construct,   and    operate   column   and   static
microcosms  with which to study the transport,  fate
and  kinetics  of selected  trace  organic pollutants
in the  saturated subsurface.

(Medium;  Ground water)

Research  studies  focus  on characterization  of the
subsurface  environment,  the transport  and  fate of
pollutants,  and development of  methods for ground
water  quality assessment  will be  developed  under
this cooperative agreement.

(Medium:  Ground water)

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FATE AMD TRANSPORT/MATERIALS  BALANCES
Title
Office/Division
Description
Sorption and Transport of
Toxic Organic Substances
in Aqueous and Mixed
Solvent Systems
ORD/Ground Water  Research
Robert S. "Kerr  Environmental
Research Laboratory
Ada, OK

A, Lynn Wood
8/743-2304
The  purpose of  this cooperative  agreement is
evaluate and describe the  influence of  the solve
phase  on   the  mobility  of   selected   synthet
organic   compounds   in   natural   porous  mec
systems.

(Medium:  Ground water)

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Title
Office/Division
Description
Pre-CHIP Screening/CHIP
Preparation/Post-CHIP
Follow-up Support
Office of Toxic Substances/
Existing Chemicals Assessment
Division

Jim Darr
382-3473
This  contract will perform  pre-CHIP screening  .of
current published  literature and prepare a  serief"
of Chemical  Hazard  Identification Profiles  (CHIPS
which  will  highlight  the  potential  health  anc
environmental  problems  associated with  particular
chemicals or groups of chemicals.   The work  will
involve   designing   and   performing   literature
searches,    obtaining   and   summarizing  relevant
information  in  a  format  specified  by  the  EPA
Project   Officer,   and   providing   a   limited
evaluation  and  interpretation of  relevant  data.
When  available,  information  concerning  exposure,
environmental  fate,  health effects,  environmental
effects  and   regulatory   status   of  the  subject
chemical will  be included.
Comparison of Sensitivity
of Laboratory Rodents with
Wild Terrestrial Animals
ORD/Environmental Research
Laboratory
Corvallis, OR

Bill A. Williams
8/420-4679
The  purpose of  this cooperative  agreement is  tc
review   literature   which   relates   comparative
toxicity of wild  animals  to laboratory animals and
supports the results  of  the literature review  with
appropriate laboratory  tests designed  to  fill any
experimental "data  gaps" which  are identified  in
the  literature.     This  is  a   laboratory   task
combined with an extensive literature  search.
Statistics and
Environmental Factors in
Health (Toxic Substances)
ORD/Health Effects Research
Laboratory
Research Triangle Park, NC

William C* Nelsen
8/629-8411
The objective  of this cooperative agreement  is  to
investigate  improved statistical  methodology  for
the   testing,    monitoring,   and   assessment   of
potentially  toxic   substances.     The  components
which  are  to  be  investigated  are:    design  and
analysis  of  animal and  in  vitro   experiments?
environmental     exposure     monitoring,      risk
assessment,  and  design and  analysis  of community
toxicology studies.

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HEALTH/ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Toxicity of Contaminated
Prey to Carnivores
Mechanisms of Metabolism
and Activity of
Cyclopenta-PAH and
Derivatives
Enzyme-Altered  Foci  in
Pish  Liver  Carcinogenesis
 Aquatic  Toxicity Testing
 and  Criteria Document
 Development
ORD/Environmental Research
Laboratory
Corvallis,  OR

Jay D.  Gile
8/420-4649

ORD/Health  Effects  Research
Laboratory
Research  Triangle Park,  NC

Dr. Joelien Lewtas
8/629-8411
 ORD/Environmental Research
 Laboratory
 Gulf Breeze,  FL

 Dr.  John Couch
 8/686-9011
 ORD/Environmental Research
 Laboratory
 Duluth,  MN

 Oilman D.  Veith
 8/783-9550
Toxicity  tests will  be  conducted using  proposed
OTS mink toxicity  test  guidelines.  Test protocols
will   compare   the    effects    of   contaminated
laboratory  food with  contaminated natural  (live)
food   sources  to   simulate  secondary   exposure
routes.

The   grant   will   identify   the  mechanisms   of
mammalian  metabolism   and   genetic  toxicological
activity   of   rused   ring   polycyclic   aromatic
hydrocarbons  (PAH's) and their  nitro-substituted
derivatives.

(Chemical:  Polycyclic  Aromatic  Hydrocarbons)

This   cooperative   agreement  will  define   three
pathogenesis  of neoplasms in fish livers following
exposure    to   known    mammalian   carcinogens.
Histochemical  methods  will  form  the  basis  for
detecting   earliest   altered   foci   (biochemical
changes) in cells.

(Ghemical:  Diethylinitrosamine)

The  objectives of  this  study  are to  extend  and
further develop (a)  the acute and chronic toxicity
tests  for  solid waste extracts,  (b) the supporting
technical   information  for   the  ammonia  criteria
document,  and  (c)  the  comparative toxicology data
base  to be  used  for determining  the relationship
of species  sensitivity  to industrial chemicals.
                                                                       (Chemical:  Ammonia)

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HEALTH/ENVIRONMENTAL EFFECTS


Title                          Office/Division                         Description


Toxicity Validation             Office of Toxic Substances/            This  contract will  provide a  review of chemicals
Chemical Review                 Health and Environmental Review        regulated  under  the  Toxic Substances  Control Act
                                Division                               for health and environmental  hazards.

                                Glen Williams
                                382-4283

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HEALTH EFFECTS
Title
Office/Division
Description
Validation of the
V79/HGPRT Cell Culture
Assay for Tumor-Promoting
Chemicals
Office of Toxic Substances/
Health and Environmental Review
Division

Diane Beal, Harry Milman
382-4256
The V79/HGPRT  cell culture assay  is  a short  term
test  that  shows  promise  in  identifying   tumor
promoters  and  in  ranking  them according to  their
relative potency.
Workshop on Progression of
Neoplasia
Health Effects and
Evaluations
Office of Toxic Substances/
Health and Environmental Review
Division

Office of Toxic Substances/
Health and Environmental Review
Division

Glen Williams
382-4283
See:     Conferences,
Training
Symposia,   Workshops   and
The  purpose  of  this  effort  is to  provide for  a
review  of  health  hazard  assessment of  chemicals
undergoing the  Premanufacture  Review  Notification
process  under  the  Toxic  Substances Control  Act,
The  human  health  hazard  assessment will  include
structure-activity    relationships,     metabolism
(i.e.,   absorption,   metabolic  conversions   and
excretion),    acute     effects,    mutagenicity,
carcinogenicity,  teratogenicity, and other  chronic
effects.   Potential  toxic effects associated  with
the   chemical   and/or  contaminants,   byproducts,
degradation products,  etc., will be  identified.

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HEALTH EFFECTS
Title
Office/Division
                                                                       Description
Epidemiologic Support
Office of Toxic  Substances/
Exposure Evaluation Division

Joe  Carra
382-3886
Percutaneous  Absorption
Studies
 Office of Toxic Substances/
 Exposure Evaluation Division

 Frederick Kutz
 382-3569
This new  contract will  provide assistance in  the
following areas:

o   Emergency epidemiologic reviews.

o   Conducting  exhaustive  literature  reviews  or
    searches  on  epidemiology relating  to  priority
    chemicals or methodologic areas.

o   Provide  epidemiologist  support  for  document
    review and critique  as  well as the preparation
    of issue papers  and  guidances.

o   Conduct  feasibility  studies  or  evaluate  the
    quality  of  such  studies  already  completed,
    including  identification  of study populations,
    and    occupational    and    other    exposure
    monitoring,  preliminary  to the  initiation of
    analytic   epidemiology   with   priority   OTS
    chemicals.

This  project will provide  percutaneous absorption
studies.     By  employing  appropriate  laboratory
animal   models,  data   may  be   extrapolated  to
humans.   Chemicals  to be studies include PCBs, MDA
and three  that have  yet  to  be  specified.    The
factors    influencing   increased   or   decreased
absorption  rates   will  be   explored  (including
synergistic/antagonistic    relationships    among
chemicals).   The results  of  these studies will be
used   in  risk   assessments.     In   addition,  a
mathematical  model  to  predict  dermal absorption
based  on  chemical  characteristics using resultant
dermal absorption data will be developed.
                                                                       (Chemicals:  PCBs, MDA)

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HEALTH EFFECTS
Title
Office/Division
Description
Human Monitoring
Initiative
Office of Toxic  Substances/
Exposure Evaluation  Division

Joe  Carra
382-3886
Genetic Toxicology
Research
 ORD/Health and Environmental
 Research  Laboratory
 Research  Triangle Park,  NC

 Michael D.  Waters
 8/629-2537
One objective  of this project  is to identify  the
appropriate companion medium  (i.e.,  blood,  breath,
urine,  mothers'  milk, etc.)  to adipose  tissue  to
maximize   OTS"   ability  to   monitor   chemicals
regulated  under  the  Toxic   Substances  Control
Act.   Upon selection of  such a medium,  specimens
will  be  collected  through  a  rigorous  sampling
scheme  and   will  undergo  broad   scan  chemical
analysis   to   identify  the  range   of   compounds
detectable in  this medium.   Another major  output
of  this effort  will  be  the  implementation of  an
improved  survey  design  to  collect chemical  body
burden  data found in human adipose  tissue.

This  contract  modification  will provide  support
for on- and off-site genetic  toxicology  research.

(Chemicals;

Benzo(a)pyrene
N-methyl-N'-Nitro-N-Nitrosoguanidine
2-Acetylaminofluorene
Acetaldehyde
Glyoxal
Methyl-glyoxal
Per oxyac yIni tra te
Toluene
2-Aminofluorene
Dime thyIni tro s ami ne
Butadiene
Styrene
Vinyl carbamate
Cyclophosphamide)
                                                                10

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HEALTH EFFECTS
Title
Office/Division
Description
Workshops on Toxicity
Assessment  Issues
Species Conversion
Toxicity Models
Preparation of  Health
Assessment Documents
Health  Effects  Related to
Water Quality
 Health  Assessments  at
 Hazardous Waste Sites
ORD/Office of  Health  and
Environmental  Assessment
Cincinnati, OH

ORD/Office of  Health  and
Environmental  Assessment
Ci nc innati, OH

Rick Hertzberg
8/684-7531

ORD/Office of  Health  and
Environmental  Assessment
Ci nc i nna ti, OH

Steven  D.  Lutkenhoff
8/684-7531

ORD/Health and Environmental
Research Laboratory
Cincinnati, OH

Guther  Craun
8/684-7205

Office  of  Emergency Remedial
Response

Priscilla  Holtzclaw
382-2198
See:     Conferences,   Symposia,   Workshops   and
Training
This new  contract will provide for  the  validation
of species conversion toxicity models.
This new contract  will  provide for the development
of health  assessment documents on  three  Hazardous
Air Pollutant (HAP) chemicals.

(Chemicalsi  Hazardous Air Pollutants)
(Medium;  Ai r)

This  new  contract will  provide  research  on  the
relationship of water quality and congenital  heart
disease.

(Medium:  Water)
This  project will  provide  for the  development  of
guidance   relating   to  health   assessments   at
hazardous waste  sites.
                                                                11

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Title
Office/Division
Description
Toxicology Support
Preparation of Current
Awareness Reviews on
S tructure-Activi ty
Relationships:  Support
Documents for the
Assessment of Health
Effects of Chemical
Subs tances
Office of Pesticide Programs

Judy Heckman
557-7634
Office of Toxic Substances/
Existing Chemicals Assessment
Division

Joseph Arcos
382-3478
This contract  will provide analytical support for
comparative  risk   assessments,   toxicology  data
review  and  validation  as  well  as  for regulatory
actions«

(Chemicals;  Pesticides)

This  contract  aims  to  enhance  understanding  of
established  knowledge  and  awareness  of  emerging
new     developments     in      structure-activity
relationships.   The  products  developed  in this
contract   are   structure-activity    relationship
analysis   documents   specifically   oriented   to
support          carcinogenic!ty/mutagenicity/tera-
togenicity hazard  assessment of  PMN and existing
chemicals  submitted   to  EPA.     Such   documents
containing systematically organized and up-to-date
information  in  these   areas  are   not   available
eIs ewhere.
                                                                       (Chemicals;

                                                                       o   difuroxanthone-type  alkylating  agents
                                                                       o   polynuclear  lactone  alkylating  agents
                                                                       o   nitrosamine    congener    alkylazoxy-methanol-
                                                                          derived alkylating agents
                                                                       o   pyrolizidine derivative  alkylating agents
                                                                       o   hepatotoxins containing  anthraquinone nucules
                                                                       o   safrole and  its  congeners
                                                                       o   tannins and  flavonoids
                                                                       o   industrially used   lipid  chemicals  of  plant
                                                                          origin
                                                                       o   water soluble high polymers)
                                                               12

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HEALTH EFFECTS
Title
Office/Division
Description
Transfer of Xenobiotics  in
Blood Cells
ORD/Office of Exploratory
Research

George R. Simon
382-5744
This  project will  study  the role  of lipids  and
lipoproteins  in  the  transfer  of  lipid  soluble
foreign compounds into cells.
Mechanisms of Mutagenesis
by Environmental
Care i nogens
ORD/Office of Exploratory
Research

Clyde C. Bishop
382-5741
This  grant  will  identify  specific  pathways  of:
genetic change which  result from specific types of
chemically-induced  lesions in  DNA and which  play
an important role in carcinogenesis.
Comparison of In Vivo and
In \ritro Procedures  for
Determining Alterations in
Liver Functions
Cytogenetic Effects of
Chemical Mutagens of
Sipe raa togenes is
ORD/Health Effects Research
Laboratory
Research Triangle Park, NC

Dr. Robert Chadwick
8/629-8411

ORD/Office of Exploratory
Research

Clyde Bishop
382-5741
This  cooperative  agreement will  compare  compound-
induced liver function  involving  the metabolic end
products of endrin, a chlorinated hydrocarbon.

(Chemicals  Endrin)
This grant will  obtain detailed information on the
gamete since  the gamete  is  the only genetic  link
between  two  generations,  and  develop  a  reliable
and  economical  test  protocol  for  environmental
mutagens using  male gametogenetic elements  as  the
test material.
                                                               13

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niuuyrn
Title
Office/Division
Description
Effects of Toxic Chemicals
on Pre- and Post-Puberty
Testicular Function
Epidemiology Research
Center
Cytogenetic  Analysis  for
the L5178/TKt/-Mouse
Lymphoma  Hutagenesis  Assay
System
Effects  of  Varying Doses
of  W Mammalian Skin:
Simulation  of  Decreasing
Stratospheric  Ozone
 Chemical  Axonopathy
 Detected  by Stimuli of
 Increasing Frequency
ORD/Health Effects Research
Laboratory
Research Triangle Park,  NC

Neil Chernoff
8/629-4061
ORD/Health  Effects  Research
Laboratory
Cincinnati,  OH

Gunther  Craun
8/684-7422

ORD/Health  Effects  Research
Laboratory
Research Triangle Park,  NC

Dr.  Martha  Moore
8/629-3933

ORD/Office  of  Environmental
Engineering and Technology

Dr.  Herbert. L. Wiser
382-7676
 Office of Toxic Substances/
 Health and Environmental Review
 Division

 Tina Levine
 382-3454
This    cooperative    agreement    sets   out    to
systematically  assess  the potential  of a  variety
of  toxic  chemicals  to  affect testicular  function
in   animals   ranging   in   age    from  birth   to
adulthood.   The means  of assessing alterations  in
sperm   competency   will  invoke   newly  developed
techniques which utilize  flow cytometry.

The  purpose of  this cooperative  agreement is  to
develop     epidemiological    methodologies    and
epidemiological  studies  with  emphasis on  problem
definition and feasibility studies.
The  purpose  of  this  assistance  amendment is  to
analyze  the type  of  genetic damage  detectable  by
the L5178/TKt/- mouse  lymphoma  assay.
Albino  and  pigmented hairless mice will be exposed
to  solar  simulating radiation  to  determine  cancer
producing  potential of DVB  (290-320nm)  increments
combined  with  varying doses  of  UVA  (320-400nm);
assess   systemic  and  antigenic   effects   on  UV
carcinogenesis.

This  project will develop and validate the utility
of   several   functional   approaches   to   testing
peripheral  nerves for  signs  of neurotoxicity.
                                                                14

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HEALTH EFFECTS
Title
Office/Division
Description
Evaluation of Human Tissue
Supplements for Metabolism
of Xenobiotics in
Mutagenesis Studies with
V79 Cells and Human
Fibroblasts

Assessment of
Neurobehavioral Function
in Children with Elevated
Blood Lead Levels
Triethyltin-Behavioral  and
Biochemical  Changes  as  a
Function of  Early  Neonatal
Exposure in  the  Rat
The Testing of  Fetuses  and
Newborn  for Cardiovascular
Problems  After  Exposure to,
Pesticides and  Other Toxic
Subs tances
ORD/Health Effects Research
Laboratory
Research  Triangle Park,  NC

Dr. Stephen Nesnow
8/629-3847

ORD/Health Effects Research
Laboratory
Research  Triangle Park,  NC

Dr. David A.  Otto
8/629-4146

ORD/Health Effects Research
Laboratory
Research  Triangle Park,  NC

Dr. Lawrence  W.  Reiter
8/629-2671

ORD/Office of Exploratory
Research

Clyde  C.  Bishop
382-5741
The  purpose  of  this  assistance amendment  is  to
evaluate   the  possibility   of  using   materials
derived  from  human  tissue  as  supplementals  for
metabolic activation  in mammalian cell mutagenesis
bioassays   to  identify  environmental   materials
hazardous to humans.

The  purpose of  this  assistance  agreement is  the
replication  and clarification in  an  independent
sample   of  preliminary  neurobehavioral  results
observed in lead-exposed young  children.

(Chemical;  Lead)

Detailed studies on the  effects of  early postnatal
exposure to triethyltin  on  the learning and memory
of rats will be conducted.

(Chemical;  Triethyltin)
The  purpose  of this grant  agreement  is  to develop
fetal  and  neonatal electrocardiography  of  small
mammals   as   standardized  tests   for  evaluating
developmental  toxicity.

(Chemical:   Pesticides)
                                                                15

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HEALTH EFFECTS
Title
Office/Division
 Description
Evaluation of the
Reproductive Effects of
Chlorine Dioxide, Chloramine
and Chlorine Administration
in the Drinking Water of
Bats.
Initiation and Promotion
Assay of Halogenated
Ethanes, Benzenes, and
Phenols in Mouse Liver
Organic Contaminants in
Drinking Water:
Toxicological Effects in
the Developing Rat
Reproductive/Teratologic
Assessment and
Pharmacokinetics of
Selected Contaminants in
Drinking Water
 ORD/Health Effects Research
 Laboratory
 Cincinnati,  OH

 M,  Kate  Smith
 8/684-7577
ORD/Health Effects Research
Laboratory
Cincinnati, OH

Dr. Michael A, Pereira
8/684-7411

ORD/Health Effects Research
Laboratory
Cincinnati, OH

R. Dana Laurie
8/684-7436

ORD/Health Effects Research
Laboratory
Ci nc innati, OH

Dr. Kate Smith
8/684-7577
 The  major objective of this project is  to
 evaluate  the  reproductive  effects  of
 ingestion of  drinking water disinfectants
 in both males and  females.
 (Chemicals;
   Chlorine)
Chlorine   Dioxide,   Chloramine,
This project  will evaluate the  carcinogenicity  of
halogenated chemicals  in order  to determine  their
mechanisms of action.

(Chemicals:  Ethanes, Benzene, Phenol)
The overall  objective  of this assistance amendment
is to develop  an  integrated  approach to screen for
developmental  toxicity of organic  concentrates  in
drinking water.

(Medium:  Drinking Water)

The purpose  of  this  cooperative  agreement is  to
supply  information  concerning  reproductive  and
developmental  toxicity of specific  drinking water
contaminants *

(Medium;  Drinking Water)
                                                               16

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HEALTH EFFECTS
Title
Office/Division
Description
Formation and Distribution
of Organic N-Chloramines
from the Ingestion of
Chlorinated Drinking Water
Evaluation of Health
Effects of Bio-Available
Oligomeric Residues of
Polymeric Coagulants  in
Drinking Water
Methods for Assessing  the
Impact of Environmental
Chemicals on Human
Fertility
ORD/Health Effects Research
Laboratory
Cincinnati, OH

F.B. Daniel
8/684-7482
ORD/Health Effects Research
Laboratory
Cincinnati, OH

J.P. Berz
8/684-7482
ORD/Office  of  Exploratory
Research

Clyde  C.  Bishop,  Jr.
382-5744
This    assistance    agreement    evaluates    the
pharmocokinetics of reactive  organic  N-Chloramines
formed  by  the  reaction  of  aqueous  chlorine  (in
drinking water) and amines  stomach fluid  and  other
body liquids.

(Chemical;  Organic N-Chloramines)
(Medium:  Drinking Water)

The  purpose of  this  cooperative  agreement  is  to
evaluate  the   toxicologic  properties  and  adverse
health  effects  of  bio-available,  low  molecular
weight oligomeric residues  in drinking water.
                                                                       (Medium;
                                                                       (Chemical:
             Drinking Water)
             Oligomeric Residues)
The purpose  of this grant agreement  is  to develop
a  protocol  that  can  be  used  to  determine  the
potential   of  environmental   agents   to   induce
reduced  fertility in men  and determine  the  human
chorionic   gonadotropin   (hCG)  levels   to  early
abortion in women.
                                                                17

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ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Acid Deposition Experiment
Environmental Effects of
Air Pollutants
Network Biomonitoring
Using Honeybees
Fish Population  Changes
and the Mechanisms
Associate! with  Change ia
an Acidified Lake;   Pre-
Acidification Period
Assessing  the  Effects  of
Chronic  Stress on
Freshwater Wetland  Plant
Communities  and Soil
Properties:  A Data-Base
Modelling  Approach
ORD/Environmental  Sciences
Research Laboratory
Research Triangle  Park, NC

Francis Pooler
8/629-4551

ORD/Office of Health  and
Environmental Assessment
Research Triangle  Park, NC

Vandy Bradow
8/629-3797

ORD/Environmental  Research
Laboratory
Corvallis, OR

Eric M. Preston
8/420-4636

ORD/Environmental  Research
Laboratory
Dai-nth, .MS

John G. Eaton
8/783-9557

ORD/Office of Research Grants &
Centers

Rufus Morison
382-5741
This new  contract will provide a  technical  design
plan for a regional acid deposition experiment.
This   new  contract  will   provide  for   a   NATO
Committee  on  the   Challenge   of  Modern  Society
report  on   the   effects  of  air   pollutants   on'
visibility and climate.
The  objective of this  project is to  evaluate  the
feasibility  of  a  network  biological  monitoring
program   using   honeybees   for   both   exposure
potential and effects.
This   grant  will  define   changes  in   relative
abundance  and size structure  of all fish  species
populations?  define  mechanisms  through which  lake
acidification   alters   year-class   survival   in
important  species populations.
This  project identifies key properties  of wetland
vegetation  and  hydrologic reimes that  interact to
determine   distribution  and  growth   of  wetland
plants in temperate and boreal climates.
                                                          18

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ENVIRONMENTAL EFFECTS
Title
SCE Assay for Waterborne
Genetic Hazards
Effects  of  Varying  Acidic
Conditions  on the
Survival, Development,
Growth  of Salmonid  Fishes
 Aquatic Toxicology:
 Testing and Evaluation
 Marine Sciences Research
 Center
Office/Division


Office  of  Research  and
Development

George  R.  Simon
382-5744

ORD/Environmental Research
Laboratory
Corvallis, OR

Gary Chapman
8/420-4876
 ORD/Environmental Research
 Laboratory
 Duluth, MN

 Dr. Rosemarie C. Russo
 8/783-9572
 ORD/Environmental Research
 Laboratory
 Narragansett, RI

 Dr. Robert Payne
 8/838-4843
Description
This  project will  measure  genetics damage  caused
by waterborne  chemicals in the  estuarine  teleost,
Opsanus tau.

(Medium;  Water)

Laboratory  acute and  chronic toxicity  tests  will
be conducted to determine the effects  of  episodic
exposures  to acidic  pH and  aluminum  on survival,
development,  and  growth of  juvenile,  larval  and
embryonic trout under  this cooperative agreement.

 (Chemical;  Aluminum)
 (Medium;    Wa te r)

 The  purpose of this  cooperative  agreement  is to
 improve  methods for aquatic  toxicology testing and
 evaluation  so  that more confident application of
 aquatic  toxicology information  to natural systems
 can  be made.

 (Medium;  Water)

 A  study   of   nutrient  additions  to  Estuarine
 Mesocosms,  and  development  of  information base on
 the  potential  effects  of  ocean  disposal  of  low-
 level radioactive  wastes will  be conducted under
 this cooperative agreement.  Study includes  impact
 of air particulate matter on land and water.

 (Medium:  Water)
                                                           19

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ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Effects Assessment of
Ocean Disposed Wastes on
Estuarine and Marine
Organisms
Effects of Hydraulic
Gradient and Field Testing
on Hydraulic Conductivity
of Soil
Studies in Natural Aquatic
Habitats of the Effects of
Agricultural Herbicides on
Aquatic Food Chains
Effects of Methyl
Parathion on Wild Avian
Species in Agricultural
Areas of Skagit Valley,
Washington
ORD/Environmental Research
Laboratory
Narragansett, RI

Richard W. Latimer
8/838-4843

ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Walter E. Grube
8/684-7871

ORD/Environmental Research
Laboratory
Corvallis, OR

David P. Larsen
8/420-4877
ORD/Environmental Research
Laboratory
Corvallis, OR

Eric Preston
8/420-4636
This cooperative  agreement  will  support studies to
assess  the  effects  of  ocean disposed  wastes  on
estuarine and marine organisms.

(Medium:  Water)
This  project will  develop  experimental data  that
will  help  to  clarify  the  effect  that hydraulic
gradient  and other  operational  variables  have  on
the apparent hydraulic conductivity of clay soils.

(Medium;  Ground water)

The purpose of  the cooperative  agreement is  two-
fold:      (1)  to  monitor  the experimental   ponds
through their  third year  of atrazine  exposure,-  (2)
to develop  a broader understanding of  the effects
of  chemical stressors on  aquatic  ecosystems  by
examining    patterns    of   response    in    other
experimental studies.

(Chemical:  Atrazine)
(Medium;    Wa te r)

This  is a field study to determine the  effects  of
Methyl Parathion  on non-target avian species  such
as  waterfowl  and  passerines.   This  is a  large-
scale  evaluation  of the  actual effects  of'< this
pesticide on birds  in the field.

(Chemical;  Methyl  Parathion)
                                                         20

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ENVIRONMENTAL EFFECTS
Title
Office/Division
 Description
Intermedia Transport
Research Center
Verification of an Acid
Precipitation Model for
the North-Central United
States
Long-term Chemical
Monitoring of Northern
Rocky Mountain Lakes
Evaluation of Aquatic
Resources in Wisconsin
Susceptible to Acid
Deposition
ORD/Office of Environmental
Process and Effects Research

Ed Schuck
382-5904

ORD/Environmental Research
Laboratory
Duluth, MN

Norbert A. Jaworski
8/783-9550
ORD/Environmental Research
Laboratory
Corvallisj OR

Charles F. Powers
8/420-4684
ORD/Environmental Research
Laboratory
Duluth, MN

Dr. Gary E. Glass
8/783-9550
Research studies will  be  conducted focusing on the
interactions of the  pollutants  at the air-land and
air-water interfaces.

(Media;  Multi-Media)

The  objectives  of  this  cooperative  agreement are
to validate existing models  for predicting changes
in water quality due to  the  atmospheric deposition
of acidic pollutants.   The hydrocycle  approach is
used  in  first achieving•a water  balance  followed
by chemical equilibria modeling where carbonate is
the master variable.

(Medium.;  Acid rain)

Northern  Rocky  Mountain  lakes  will  be  sampled
three times  yearly as part  of  a  National  Surface
Water Monitoring  Program  under the  National  Acid
Precipitation Assessment  Program,   The extent  of
acidification  and  sensitivity  of  surface  water
will be quantified*
                                                                       (Media:
                                                  Water, Acid rain)
The  objectives  of the  proposed  research  are  to
determine:    the past  and present  conditions  of
lakes and  streams, terrestrial resources and  land
use;  and  resources  susceptible  to  damage   from
atmospheric deposition.
                                                                       (Media:
                                                  Water, Acid rain)
                                                         21

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ENVIRONMENTAL EFFECTS
Title
Office/Division
Description
Fish Population Changes
and the Mechanisms
Associated With Change in
an Acidified Lake
Simulated Acid Rain
Effects on Yield  and
Growth of Corn and Soybean
and Soil Parameters
The Effects  of  Acid
Precipitation of Aquatic
and Terrestrial Ecosystems
ORD/Environmental  Research
Laboratory
Duluth, MN

John G. Eaton
8/783-9557
ORD/Environmental  Research
Laboratory
Corvallis,  OR

Jeffrey  J.  Lee
8/420-4758
 ORD/Environmental Research
 Laboratory
 Corvallis, OR

 Raymond G. Wilhour
 8/420-2634
The  studies   will  define  changes  in   relative
abundance and  size structure  of all fish  species
population;  define mechanisms  through  which  lake
acidification   alters   year-class   survival   in
important species populations.

(Medium;  Water, Acid Rain)

This project is an integral part  of EPA's program
to  assess  the effects   of  acid  deposition  on
agriculture.    The  University  of  Illinois  will
develop  dose-response  relationships   for  field-
grown  corn  and  soybeans.   Physiological  and  soil
measurements   will   aid    in   understanding   the
mechanisms  by  which  yield is  affected,  and  in
extrapolating results to other locations.

(Medium;  Acid  Rain)

The  purpose  of this  assistance  agreement is  to
coordinate,   manage   and   conduct  research   to
determine   actual   and    potential   effect   on
terrestrial   and  aquatic   components   of  lake-
watershed   ecosystems    characteristic   of   the
northwestern U.S.

(Medium:  Water, Acid Rain)
                                                          22

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EXPOSURE
Title
Office/Dim sion
Description
Biotechnology Methods
Development  (Exposure  and
Risk)
Office of Toxic  Substances/
Exposure Evaluation Division

Joe Carra
382-3886
The purpose of this project  is  to determine whether
existing regulations  are adequate for  dealing  with
human  exposure  to  Biotechnology  products.    The
following concerns will be addressed:

o   whether  existing  chemical  monitoring  networks
    are   capable   of   measuring   levels   of   bio-
    technological products in the environment

o   whether   the   fate  problems  associated   with
    genetic  bodies are understood  well enough  to
    develop   regulations  for   disposal   of   bio-
    technological products

o   if  adequate  exposure  data  exist  for  making
    rational decisions
 Environmental Fate
 Office of Pesticide Programs
o   if  it  is  feasible  to  develop  a program  for
    monitoring   the   impact  of   biotechnological
    processes   and   products  for  the  purpose  of
    assessing the need/effectiveness  of regulations

o   development of  an exposure analysis methodology
    for  application to  genetically  engineered life
    forms.

 (Industry:   Biotechnology)

 See:   Fate  and  Transport/Materials  Balances
                                                          23

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EXPOSURE
Title
Office/Division
Description
Existing Chemicals Task
Force Support
Office of Toxic
Substances/Exposure Evaluation
Division

Frederick Kutz    382-3569
Joe Carra  382-3886
Environmental Exposure
Assessments
Minimum Worker  Protection
Factors for Respiratory
Protective Devices
ORD/Environmental  Research
Laboratory
Athens, GA

Lee  A. Mulkey
8/250-3581

Office of Toxic  Substances/
Economics and Technology Division

William Burch
382-3664
This project  will provide environmental and human
exposure assessments  for chemicals considered  for
action  under  TSCA Section  6.   Accordingly, field
human  and/or  environmental  exposure  monitoring
studies  will  be  done  on five chemicals:   PCBs,
formaldehyde  and  three  other  as  yet  unspecified
chemicals.    For  situations  where  actual field
monitoring is  logistically impractical, a  special
room  will be  constructed  for  simulated  consumer
exposure  studies  to  such  chemicals  as   paints,
solvents, volatile organics, etc.

(Chemicals:  PCBs
             Formaldehyde
             Paints
             Solvents
             Volatile Organic Compounds)

This   basic   ordering    agreement   will   provide
technical   support   for  environmental   exposure
assessments "of pesticides and toxic substances.

(Chemicals:  Pesticides)
This  project  will investigate the effectiveness of
respirators   in   actual   field   conditions   in
comparison with laboratory  fit  test  results.
                                                          24

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EXPOSURE
Title
                 Office/Division
                                  Description
Selection and
Effectiveness  of
Protective Gloves
Support  for Exposure
As sessments
                 Office of Toxic Substances/
                 Economics  and Technology
                 Division

                 William  Bureh
                 382-3664

                 Office of  Emergency Remedial
                 Response

                 Richard  Stanford
                 475-8115
                                  This project  involves the development of a
                                  methodology  to  predict  the effectiveness
                                  of   chemical   protective    clothing   for
                                  specific chemical substances.
                                  The intent  of  this project is  to  produce a
                                  background   document   and    a    guidance
                                  document  on exposure assessments  for  the
                                  Feasibility Study Guidance Manual.
Tolerance
Sys tern
Asses sment
Office of  Pesticide Programs

Judy Heckman
557-7634
This  contract will  provide
approved    data   on    food
parameters.

(Chemicals:   Pesticides)
an update  and
   consumption
Review and  Evaluation
of Available Dioxin
Emissions Data for
Combustion  Sources
                 Office of  Air  Quality
                 Planning and  Standards

                 Bill Lamason
                 8/629-5585
                                  This   work   assignment   is   to   collect,
                                  organize,  review  and  evaluate  available
                                  emissions- data  for  dioxin  isomers  from
                                  combustion  sources.    The  collected  data
                                  will  be  used  in  the planning of  a  source
                                  test   program  for   the   National   Dioxin
                                  Study.
                                                              (Chemicals;
                                                              {Indus try:
                                                                 Dioxin Isomers
                                                                Incineration and  other
                                                                combustion sources)
Indoor Air  Pollution
Study
                 Region X—Air  and Waste
                 Management  Division

                 Dana Davoli
                 8/399-1981
                                  A  sample   of  houses   and  mobile   homes
                                  totalling   100   will   be   analyzed   for
                                  formaldehyde,  fungus,  CO,  NOx,  TSP,  etc.
                                  before  and  after'  installing  a  retrofit
                                  system   designed    to    reduce  pollutant
                                  levels.

                                  (Chemical:  Formaldehyde)
                                                  25

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EXPOSURE
Title
Office/Division
                                                              Description
Clothing  Material
Consideration
Electrophys iological
Battery for Assessing
the  Effects of
Exposure to Toxic
Subs tances
 Study of Stability  of
 Residues in Stored
 Adipose Tissue
ORD/Municipal Environmental
Research Laboratory
Edison,  NJ

Mike  Royer
8/340-6633

ORD/Health Effects  Research
Laboratory
Research Triangle  Park, NC

Dr.  David A. Otto
8/629-8411
 Office of Toxic  Substances/
 Exposure Evaluation Division

 Frederick W. Kutz
 382-3569
This task  assignment will  provide clothing
material    guidelines   to    reduce   user
exposure  to highly toxic pesticides.
Application    of    a    minibattery    of
electrophysiological  tests  to a  selected
population;   construction  of  a  normative
data base  for selected  tests;  expansion of
results      of      coordinated     studies;
development  of  application  software  and
appropriate  hardware  interfaces  will  be
done under this assistance agreement.

Human  tissue   specimens  will  be  analyzed
for  toxic  substance   residue.     Project
Results  will   be  reported  by  EPA  to  the
World  Health  Organization  and  The  United
Nations  Environmental  Program.
                                                   26

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RISK
Title
Office/Division
Description
Support for Environmental
Hazard and Risk Assessment
Office of Toxic Substances/
Health and Environmental Review
Division

Don Rodier
382-4276
This   contract  will   provide  support   in  the
development  of  environmental  hazard  and  risk
assessments   for  new   and   existing  chemicals
regulated  under  the Toxic  Substances  Control Act
(TSCA).   Single and  multispecies  models  will be
developed  for performing  Ecological  Effect Risk
Assessments.
Risk Extrapolation
Office of Toxic  Substances/
Exposure Evaluation Division

Joe Carra
382-3886
This  work assignment  will  provide  assistance  in
modifying  high-to-low  dose  risk  extrapolation
modeling  techniques so  they  may be readily used  in
risk assessments.  This  may  be done either through
programming  these  models or by  modifying them  to
accept  inputs  of environmental exposure levels  in
order to  calculate risk  levels.
Studies for National
Ambient Air Quality
Standards  (NAAQS)
Extrapolation  of  Animal
Data  for  Assessing  Ozone
Risks
 Office Air  Quality Planning  and
 Standards/Strategies  and Air
 Standards Division

 Tom  Feagans
 8/629-5655

 Office of Air Quality Planning
 and  Standards/Strategies and Air
 Standards Division
This   contract   provides   studies   needed   for
development  of a  public  health  risk  methodology
for NAAQS and other related technical studies.
See:  Modeling
 Toxicology Support
 Office of  Pesticide Programs
 See:  Health Effects
                                                          27

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RISK
Title
Office/Division
                                                                       Description
Risk Decision Model for
Controlling Toxic
Substances in EPA
Laboratories
Quantitative  Human
Reproductive  Risk
Assessment
Risk Assessment of
Airborne  Toxic  Substances
Office of Policy Planning and
Evaluation Office of Personnel
and Organization—Occupational
Health and Safety Staff

David Weitzman
382-3640
 ORD/Office  of  Health and
 Environmental  Assessment

 Carol  Sakai
 382-2873

 ORD/Environmental Sciences
 Research  Laboratory
 Research  Triangle Park,  NC

 Len Stockburger
 8/629-2554
This  contract will  provide a  simple,  efficient,
and interactive decision model for determining the
appropriate  level  of control for  the handling of
toxic substances  in EPA  laboratories  as  a result
of the Superfund program.

(Chemicals:   Methylene chloride
              Ether
              Malathion
              Chromic acid
              Formalin
              Benzene
              2,3,7,8 - Tetrachlorodibenzo-
              (Dioxin)
              Lindane)

The  purpose  of  this cooperative  agreement is  to
develop  procedures  for  quantitatively  assessing
adverse  male reproductive  effects resulting  from
toxic chemical exposure.


The  overall purpose  of  the  flow reactor project  is
to    provide    chemical    characterization   and
biological   testing  data  for   input  to  the  Risk
Assessment  Model developed by  Oak Ridge  National
Laboratory.
                                                          28

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RISK
Title
Office/Division
                                                                       Description
Fish Surrogates for Higher
Vertebrates in Risk
Assessment
Comparative Valuation of
Human  Health  Risk
Reduction  and Refinement
of Visibility Valuation
ORD/Environmental Research
Laboratory
Duluth, MN

James M.  McKim
8/783-9567
ORD/Office of  Exploratory
Research
The cooperative  agreement is designed to evaluate
the feasibility  of  subrogating fish toxicity data
with  that  for  mammals  in  order  to   facilitate
regulatory considerations*   This objective will be
accomplished  by  analyzing  the  correlativity  of
toxic potency ratios  of  selected chemicals between
various species of fish and mammals„

See:  Economic Studies
                                                           29

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INDUSTRIAL  STUDIES
Title
Office/Pivi sion
Description
Data Collection for
Industry Studies
Industrial Data Index
De ve 1 opine n t
Office of Solid Waste

Wanda LeBleu-Biswas
382-4796
Office of Toxic Substances/
Economics  and  Technology
Divis ion

Justin  C.  Powell
382-3689
This new contract will provide for data collection
for  industry  studies  (including   the   organic
chemical industry).   This effort will support the
hazardous waste listing effort.

(Indus try:  Organic Chemical)

This   project   will   survey   data   needs,
develop  approaches  to  meet  these  needs,
and  plan  implementation  of   an  index  of
chemical   product   documents   that    will
greatly   facilitate   retrieval   of    data
relevant  to   chemical   identity,   chemical
and physical  properties,  chemical  uses  and
application,   bibliographic  documentation,
data   categories,    and    abstracts.      The
output  will  be  a  report  that  can  be  the
basis  of  a future  project to  develop  an
automated  database.
                                                       30

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ECONOMIC STUDIES
Title
Office/Division
Description
Cost/Benefit Analysis
Support
 Cost  and  Economic Analysis
Office of  Air  Quality Planning
and Standards/Strategies  and  Air
Standards  Division

Janet Scheid
8/629-561 1

Office of  Air  Quality Planning
and Standards/
Strategies and Air Standards
Division

Richard  Jenkins
8/692-5610
This project  will  conduct a cost/benefit analysis
to potentially  support  selected NSPS which reduce
sulfur oxide and/or particulate emissions.

(Medium:  Air)
This  contract  provides   for   cost  and   economic
analysis  of  alternative  air   pollution  control
regulations  for  New Source Performance Standards,
(NSPS),  National  Emission Standards  for Hazardous
Air  Pollutants  (NESHAP),  and National Ambient  Air
Quality  Standards  (NAAQS).

(Chemicals;

NAAQS

Ozone
Particulates
Lead
Sulfates/Acid Rain-Secondary Standard
Fine Particulates-Secondary Standard

NESHAPs
                                                                       Acetaldehyde
                                                                       Acrolein
                                                                       Acrylonitrile
                                                                       Allyl Chloride
                                                                       Benzyl Chloride
                                                                       Bis  (Chloromethyl) Ether
                                                                       Carbon Tetrachloride
                                                                       Chlorobenzene
                                                                       Chloroform
                                                                       Chloromethylmethyl Ether
                                                                       Chloroprene
                                                           31

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ECONOMIC STUDIES
Title
Office/Division
Cost and Economic Analysis
(cont.)
                                                                       Description
                                       o-, m-, p-Cresol
                                       p-Dichlorobenzene
                                       Dimethylnitrosamine
                                       Dioxane
                                       Epichlorohydrin
                                       Ethylene Dibromide
                                       Ethylene Dichloride
                                       Ethylene Oxide
                                       Formaldehyde
                                       Hexachlorocyclopentadiene
                                       Maleic Anhydride
                                       Manganese
                                       Methyl Chloroform
                                       Methylene Chloride
                                       Methyl Iodide
                                       Nickel
                                       Nitrobenzene
                                       2-Ni tropropane
                                       N-Ni trosodi e thylamine
                                       Nitrosoethylurea
                                       Nitrosomethylurea
                                       Nitrosomorpholine
                                       Perchloroethylene
                                       Phenol
                                       Phosgene
                                       Polychlorinated  Biphenyls  (PCBs)
                                       Propylene Oxide
                                       Toluene
                                       Trichloroethylene
                                       Vinylidene Chloride
                                       o-, m-r  p-Xylene
                                       Cadmium
                                       Arsenic)
                                                          32

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ECONOMIC STUDIES
Title
Office/Division
                                                                       Description
Cost and Economic Analysis
(cont.)
                                       (industries/Industrial Processes:

                                       NSPS

                                       Hydrogen Fluoride
                                       Perlite
                                       Phosphoric Acid:  Thermal Process
                                       Secondary Zinc
                                       Uranium Refining
                                       Alfalfa Dehydrating
                                       Animal Feed Defluorination
                                       Detergent
                                       Gasoline Additives
                                       Robber Products
                                       Fabric Printing
                                       Synthetic/Organic Chemical
                                          Manufacturing  Industries  (SOCMI)
                                       Polymers & Resins
                                       Geothermal Energy
                                       Oil  Shale
                                       Utility  Steam Generators
                                        Aluminum products
                                        Electric Arc  Furnace Operations
                                        Copper Mining/Processing
                                        Coal Gasification
                                        Mineral  Wool
                                        Explosives
                                        Municipal  Incinerators
                                        Crude Oil  and Natural Gas Production
                                        Varnish
                                        Printing Ink
                                        Synthetic  Fibers
                                        Plywood Manufacture
                                        Industrial Surface Coating:  Large Appliances
                                        Incineration:  Organic Liquid Wastes
                                        Foundries:   Steel
                                        Sintering:   Clay and Flyash
                                        Gypsum
                                        Fiberglass
                                                           33

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ECONOMIC STUDIES
Title
Office/Division
Description
Cost and Economic Analysis
(cont.)
                                       Brick and Related Clay Products
                                       Ammonia
                                       Ceramic Clay
                                       Castable Refractory
                                       Starch)
Energy, Environment and
Cost Impact Analysis
Support
Multi-client  Market
Studies
 Dioxin Task Force
 Economic Support
 Health Econometric Methods
 for Air Pollutants
Office  of Air  Quality  Planning
and Standards/Strategies  and Air
Standards Division

Robert  Short
8/629-5611

Office  of Toxic
Substances/Economics and
Technology  Division

Ron Evans
382-3712

Office  of Emergency Remedial
Response

Conrad  Kleveno
382-7906

Office  of Pesticide Programs

Robert  Lee
557-7345
 Office of Policy Planning and
 Evaluation

 George Provenzano
 382-5732
This project will provide an energy, environmental'
and cost  impact analysis for  major energy sector
New Source Performance Standards development.
This procurement will  allow  ETD  (Regulatory  Impact
Branch)  to  purchase  existing  marketing studies
that are  usually proprietary, providing  data  that
would  otherwise not be  available to  EPA.   These
studies  will  assist  staff   in  understanding   how
each PMN substance fits into  the general market.

This  project will  perform a  study  on the  risks,
benefits, and costs of land disposal of dioxins.

(Chemicals:  Dioxins)
This  task  order will provide for data and analysis
of  this   data   primarily  focused  on  supporting
regulatory impact  analysis.

(Chemicals:   Pesticides)

Using  econometric  techniques,   the   grant  will
develop  improved   methods   for   estimating   the
economic    health    benefits   associated    with
controlling air pollutants.

 (Medium:   Air)
                                                          34

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ECONOMIC STUDIES
Title
Office/Pivi s io n
Description
Health Econometric Methods
for Multimedia Pollutants
Economic Analysis of
Pesticide Use
Comparative  Valuation of
Human Health Risk
Reduction and Refinement
of  Visibility Valuation
Office of Policy and Research
Management

George Provenzano
382-5732
Office  of  Pesticides
Programs/Benefits  and Field
Studies Division

Robert  J.  Lenahan
8/557-7335

ORD/Office of  Exploratory
Research

Alan Carlin
382-5754
Using  econometric  techniques,  this  grant  will
develop   improved   methods   for   estimating  the
economic    health    benefits    associated   with
controlling multimedia  pollutants subject to EPA
regulation.

(Media:  Multi-media)

This  cooperative  agreement will  provide data for
risk/benefit   regulatory  decisions   on  problem
pesticides which affect state economies.

(Chemical:  Pesticides)
This  grant  will  develop  and  demonstrate  methods
for  valuing  the  economic  benefits  of  reducing
health    risk    using    contingent    valuation,
environmental   health   econometrics   and   other
techniques   as  appropriate,   and  refining   the
economic    benefits    of   improved    visibility,
particularly in the Eastern United States.
                                                          35

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
Description
Polychlorinated bipheriyls
(PCBs) Disposal Project
Office of Toxic Substances/
Exposure Evaluation Division
                                Frederick Kutz
                                Joe Carra
                 382-3569
                 382-3886
Land Disposal Ban:
Treatment Alternatives
Office of Solid Waste

Steve Lingle
382-7917
Industry Furnace Tests
Office of Solid Waste

Dave Sus siuan
382-7917
The purpose  of  this work assignment is  to  provide
technical  information and  support which  will be
used  to evaluate  permit  applications  to  operate
PCB   disposal   facilities.       Instrumentation,
equipment and qualified  personnel  will be provided
to  conduct  in-the-field  studies   and   laboratory
analyses.  These will include;   source monitoring;
sample collection and analysis;  process  evaluation
and  review  of   test  plans;  assessment  of  QA/QC
procedures   contained   in   permit  applications;
review   and   evaluation   of   existing   process
demonstration data;  and  characterization  of wastes
and by-products.

(Chemicals;  PCBs)
{Medium:  Land)

This  new  contract  will   identify and evaluate'
treatment  . methods   for   hazardous   wastes  as
alternatives  to  land- disposal.    Information on
preferred  management options will  be disseminated
to  the  regulated  community, government  agencies,
and the public.

(Medium:  Land)

This  new  contract  will perform  full-scale  site
testing of industrial boilers and  furnaces  burning
hazardous wastes to determine operating  practices,
emissions  and  controls.    Sampling  and analyses
will  be performed  on various types of  combustion
devices  to  determine  the   current  baseline of
device  performance  in  burning  various  types of
hazardous  waste,  and waste  otherwise classifiable
as  hazardous.   Associated activities will  include
characterization of potential and  selected sites,
and   the   evaluation  of  sampling  and  anaylsis
methods for particular wastes.
                                                          36

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
Description
Technology Transfer
Program Field Test
Removal of Barium and
Radium From Groundwater
Subsurface Microbial
Characteristics and Their
Effects on Contaminant
Degradation
Investigation of Gas
Thermal Decomposition
Properties of Hazardous
Organic Compounds
Office of Emergency Remedial
Response

Conrad Kleveno
382-7906

ORB/Municipal Environmental
Research Laboratory
Cincinnati, OH

Richard P. Lauch
8/684-7467
ORD/Environmental Research
Laboratory
Ada, OK

James F. McNabb
8/743-2216
ORD/Industrial Environmental
Research Laboratory
Cincinnati, OH

Robert E. Mournighan
8/684-7696
This  project  will  field  test,  demonstrate,  and
evaluate  new   technology,   develop  manuals  for
various applications of  technology  and provide for
adaptation     of     technologies    and    cost
effectiveness.

Weak  and   strong  acid  cation  exchange   resins
incorporating  the  hydrogen  cycle   and   activated
carbon  modified  with H2SO^  will  be evaluated for
barium  and   radium  removal   from  well   water.
Efficiencies of  strong  acid  resins in the  sodium
form  will be  compared  to  weak  and  strong acid
resins  in the hydrogen  form for combined barium,
radium and hardness removal.

(Chemicals;  Barium
             Radium)

(Medium;  Ground water)

The  purpose  of  this cooperative agreement  is  to
determine  _ the   characteristics    of   subsurface
microbial  populations  which are  responsible for
degradation  of  contaminants  introduced  into the
subsurface. •

(Medium:  Ground water)

The  purpose  of  this cooperative agreement  is  to
generate thermal decomposition  data of most  common
compounds occurring  in hazardous  waste; to develop
models  for  application  of  lab-generated thermal
decomposition data to  full-scale  incineration; and
to   develop  a   scale   of  thermal  stability   of
hazardous wastes.
                                                         37

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
Description
Evaluation of Methods for
Removing Agricultural
Chemicals from Drinking
Water
Evaluation  of  Packed  Tower
Aeration  for Removal  of
Volatile  Organics
 A Report on  Methods
 Available to Decision-
 Makers  To Protect Public
 Water Supplies from  Plumes
 of Ground-water
 Contamination

 Evaluate the Performance
 of Air  Stripping and GAG
 for Removal  of TOCs
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Ben w. Lykins Jr.,
8/684-7460
 ORD/Health  Effects  Research
 Laboratory
 Cincinnati,  OH

 O.  Thomas Love,  Jr.
 8/684-7281

 ORD/Environmental Research
 Laboratory
 Ada,  OK

 James F. McNabb
 8/743-2011

 ORD/Municipal Environmental
 Research Laboratory
 Cincinnati, OH

 Ben W. Lykins, Jr.
 8/684-7460
The  purpose of  this  assistance  agreement  is to
determine  cost  effectiveness   and   efficiency of
certain  water  treatment methods  for  removal of
pesticides contamination from ground water.

(Medium:  Ground water)
(Chemical;  Pesticides)

This   assistance  amendment   will   evaluate   the
practical  and  economic aspects  of  packed  tower
aeration  for  removal  of  volatile  organics  from
drinking water.

(Medium:  Drinking water)

The  purpose  of this  assistance  agreement  is to
prepare   a   detailed   report  on   the   various
containment/control methods available under  state-
of—art technology.

(Medium:  Ground water)

The  purpose of  this  cooperative  agreement is to
evaluate  the  cost  and  performance of  granular
activated  carbon and air stripping for  removal of
volatile    organic    carbon    and    trihalomethane
precursors  from  a ground water supply,

 (Medium;  Drinking water)
 (Chemical:   VOCs, Trihalomethane)
                                                          38

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
                                                                       Description
Cost and Performance
Evaluation of In-Plant
Trihalomethane Control
Techniques
Determination of the
Removal Characteristics  of
Organic Priority
Pollutants in Biological
Wastewater Treatment
Plants
Destruction  of  PCBs  -
Environmental Applications
of  Sodium  Polyethylene
Glycolate  Complexes
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

J. Keith Carswell
8/684-7228
ORD/Environmental  Research
Laboratory
Ada, OK

Thomas E. Short, Jr.
8/743-2234
 ORD/Industrial  Environmental
 Research  Laboratory
 Cincinnati,  OH

 Charles J. Rogers
 8/684-7757
The  primary  objective  of   this  project   is   to
document    cost    and   performance    data    for
trihalomethane   control  techniques   other   than
alternate   disinfectants    at   drinking   water
treatment plants  serving populations  of 75,000  or
less.

(Medium;  Drinking Water)
(Chemical:  Trihalomethane)

The  purpose  of  this  assistance amendment  is  to
study    the   anaerobic/aerobic    treatment    of
wastewater  containing  4,6  dinitro-o-cresol,  thus
allowing    more    comprehensive   coverage    of
anaerobic/activated  sludge  treatment  in the final
report.

(Medium;  Water)
(Chemical;  4,6-dinitro-o-cresol)

The  broad objective of  this  cooperative agreement
is  to develop  and  optimize  a potentially  useful
chemical  process for  the  degradation of PCBs  and
other  halogenated  compounds  so  as   to minimize
their  impact  in  the  environment.    The specific
objective is  to  determine  the effectiveness  of the
NaPEG   reaction   in   the   treatment   of    PCB-
contaminated  soils.
                                                                       (Chemical:   PCB's)
                                                          39

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
Description
An Evaluation of
Alternative Oxidant and
Disinfectant Treatment
Strategies for Controlling
Trihalomethane Formation
in Drinking Water
Selective Sorption Median
for Acid Rain Components
Bioaccumulation of Sewage
Sorbed Toxicants
Investigation of Volatile
Organic Chemical Emission
Control Methods for
Hazardous Waste Disposal
Operations
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Ben w. Lykins, Jr.
8/684-7460
ORD/Environmental Sciences
Research Laboratory
Research Triangle Park, NC

Lester Spiller
8/629-2127
 ORD/Marine  Science  Center
 Newport, OR

 Henry Lee,  II
 8/867-4042
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Stephen C. James
8/684-7871
A pilot  and full-scale study  to  collect cost and
performance  data  for  trihalomethane  control  by
alternate   disinfectants   for   water   utilities
serving  less   than  75,000  population   will  be
conducted under this cooperative agreement.

(Chemical:   Trihalomethane)
(Medium;  Drinking Water)

An investigation  of the selectivity, capacity and
chemical reversibility of  sorbents of a novel kind
designed for  the collection  and  determination of
volatile   ammonia   in  the   atmosphere   will  be
conducted  under this  assistance  agreement.   The
utility  of such  sorption  systems  for  acid rain
components will be examined.

(Chemical:   Ammonia)
(Medium:  Acid Rain)

This cooperative agreement will assess the rates
and mechanisms of bioaccumulation of pollutants
associated with sewage particulates subjected to
different  treatments.

(Medium;   Land)

The  objective  of  this project is  to investigate
the effectiveness  of selected control options fox
the   reduction   of   secondary  volatile  organic
chemical emissions  from hazardous  waste  disposal
operations,   especially   storage   and   treatment'
lagoons.

(Chemical;  ¥OCs)
(Medium:  Land)
                                                         40

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TREATMENT TECHNOLOGY DEVELOPMENT/EVALUATION
Title
Office/Division
Description
Laboratory and Field
Studies on the Removal of
Fluoride, Nitrate,
Arsenic, and Selenium,
Using Activated Alumina
Adsorption, Ion Exchange,
Reverse Osmosis and
Electrodi alys is

Incineration Performance
Research
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Thomas J. Sorg
8/684-7370
ORD/Industrial Environmental
Research Laboratory
Cincinnati,  OH
Laboratory  studies  will  be  conducted  using  a
mobile pilot plant in several small communities to
determine removal of various chemicals.

(Chemicals:  Fluoride, Nitrate,  Arsenic, Selenium)
See:  Waste Management/Resources Recovery
                                                          41

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WASTE MANAGEMENT/RESOURCE RECOVERY
Title
Office/Division
Description
Hazardous Waste Disposal
Hazardous Waste
Incineration
 Hazardous  Waste
 Encapsulation
 Permeability of Liners
 Hazardous  Waste Treatment
 and  Storage Facility
 Emission Workshop
Region "VII

Charles Hensley
8/926-3881
ORD/Industrial  Environmental
Research Laboratory
Research Triangle  Park,  NC

D« Bruce Harris
8/629-7807

ORD/Municipal Environmental
Research Laboratory
Cincinnati,  OH

Carlton Wiles
8/684-7871

ORD/Municipal Environmental
Research Laboratory
Cincinnati,  OH

Jon Herrmann
8/684-7871

ORD/Industrial  Environmental
Research Laboratory
Cincinnati,  OH
This new contract will provide for the disposal of
dioxin-related  hazardous   waste   following  the
storage and disposal regulations.

(Chemicals;  Dioxins)

This  new  contract  will  provide  process  control
instrumentation for hazardous waste incineration.
This   new   work  assignment   will   provide  an
evaluation   of   the   encapsulation  of  hazardous
wastes.
This    work   assignment    will   evaluate    the
permeability   of   liner  materials  in  terms  of
effectiveness in hazardous waste disposal.

(Medium:  Land)
See:      Conferences,
Training
Symposia,   Workshops   and
                                                          42

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WASTEMANAGEMENT/RESOURCE RECOVERY
Title
Of fic e/Divi s ion
Description
Evaluate Hazardous Waste
Treatment and Storage
Disposal Facility Emission
Conversion  of  Abandoned
and  Idle Mineral
Processing  Kilns  to High
Capacity Incinerators
 Hazardous  Waste
 Incineration Data Base
 Hazardous  Waste Site
 Safety Considerations
ORD/Industrial Environmental
Research Laboratory
Cincinnati, OH

Edwin Oppelt
8/684-7696
ORD/Industrial  Environmental
Research Laboratory
Cincinnati,  OH

Edwin  T. Oppelt
8/684-7696

ORD/Industrial  Environmental
Research Laboratory
Cincinnati,  OH

George L.  Huffman
8/684-7881

ORD/Municipal Environmental
Research Laboratory
Edison, NJ

Mary  Stinson
 (201)340-6683
This  incremental  funding action  will  provide for
the   evaluation   and  measurement   of  non-stack
emissions  from  hazardous waste  treatment storage
and disposal facilities.

(Indus try;  Hazardous Waste Disposal)
(Medium;  Air)

This  is  a planned  effort  that  is  intended   to
provide  engineering  assessment and  test data for
conversion   of   abandoned    and    idle   mineral
processing kilns to high capacity incinerators for
the disposal of hazardous waste.
This contract modification will  provide  support  to
organize,  develop,  and  operate  a data  base for
hazardous waste incineration.
'This   task   assignment  will  evaluate   procedures
concerning    personnel   safety   and    equipment
decontamination   which   must   be    taken   into
consideration  when  working with a hazardous  waste
disposal site.
                                                          43

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WASTE MANAGEMENT/RESOURCE RECOVERY
Title
Office/Division
Description
Wastewater Sludge Workshop
Organics in Municipal
Wastewater
Evaluation of RCRA
Analytical Methods
Impact of Hazardous and
Solid Waste Regulations

Hazardous Waste Control
Me thodology
Control Measurements for
Hazardous Waste Land
Treatment
ORD/Health and Environmental
Assessment
Research Triangle Park, NC

ORD/Health and Environmental
Research Laboratory
Research Triangle Park, NC

Richard Bull
8/684-7404

ORD/Environmental Monitoring
Systems Laboratory
Las Vegas, NV

Steven Billets
8/545-2232

Office of Emergency Remedial
Response

Office of Emergency Remedial
Response

Richard Stanford
475-8115

ORD/Robert S. Kerr Environmental
Research Laboratory
Ada, OK

Marvin L. Wood
8/743-2226
See:     Conferences,   Symposia,   Workshops   and
Training
This  new  contract  will  provide  an experimental
assessment of  the hazards associated with organic
chemical pollutants  in municipal wastewater.

(Chemicals:  Organics)
(Medium:  Water)

This  new contract will  provide an  evaluation of
RCRA  Analytical  Methods  for   testing  hazardous
wastes.
See:     Policy   Studies/Regulatory   and  Control
Options

The  purpose   of  this   project   is  to  develop
protocols  for assessing  hazardous  waste control
technology.
This  project will  evaluate  control measurements
necessary  for  effective  operation  of  hazardous
waste land treatment sites.

(Medium:  Land)
                                                         44

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WASTE MANAGEMENT/RESOURCE RECOVERY
Title
Office/Division
                                                                       Description
Evaluation of High Loading
Rates and Assimilation
Capacities for Land
Treatment of Hazardous
Wastes
ORD/Environmental Research
Laboratory
Ada, OK

John E. Matthews
8/332-8800
The  purpose  of  this  cooperative  agreement  is  to
generate   a   definitive   data   base  concerning
treatability  and  maximum  acceptable application
rates for selected hazardous wastes.

(Medium:  Land)
Land Treatment Research
Project
Quantify Leak Rates
through Holes in Landfill
Liners
ORD/Robert S. Kerr Environmental
Research Laboratory
Ada, OK

Jay P. Law, Jr .
8/332-8800
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Carlton C. Wiles
8/684-7871
Acquisition and  preparation of a pilot-scale  land
treatment site;  collection, application, sampling
of  OSW-specified   wastes?   operation  of   column
studies?  management  of  field  plots?   lysimeter
operations?   loading  rate  optimization?  closure-
postclosure  operations  will  be conducted  under
this cooperative agreement.

(Medium;  Land)

The cooperative  agreement  will  measure  and model
leakage  of   fluids  through  flaws  in  landfill
liners.  Parameters to be  tested  include 4 types
of liner materials, 3  types of sub-base materials,
4  types of leachate,  2 types of  geotextiles and
the effects  of overburden soil and pressures.

(Medium:  Land)
Incineration Performance
Research
ORD/Industrial Environmental
Research Laboratory
Cincinnati, OH

Harry Freeman
8/684-7696
The  objective of  this  project  is  to  conduct a
series of  incineration research, development,  and
operational tests at an  operating commercial  scale
facility and  to  provide  access to an incineration
facility for short lead time research projects.

(Medium:   Land)
                                                         45

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WASTE MANAGEMENT/RESOURCE RECOVERY
Title
Office/Pivision
Description
An Evaluation of the
Protocol for Unsaturated
Zone Monitoring at Land
Treatment  Sites
ORD/Robert S. Kerr Environmental
Research Laboratory
Ma, OK
See:   Sampling,  Analysis  and Monitoring/Chemical
Analyses—Specific Topics
Fundamental  Approach  to
Service Life Prediction  of
Flexible Membrane Liners
(FMLs)
ORD/Municipal  Environmental
Research Laboratory
Cincinnati, OH

Paul R. DePercin
8/684-7871
This  study   will  examine  the  macroscopic  and
microscopic measurements, and optical and scanning
microscopic  observations  to  determine  if   these
evaluation methods  are capable  of  producing data
from which FML service life can be predicted.

(Medium:  Land)
 Investigation of Failure
 Mechanisms and Migration
 of Industrial Chemicals at
 Wilsonville,  Illinois
 The Impacts of Background
 Compounds on the
 Adsorption of Hazardous
 Organics from Concentrated
 Liquids and Solid Waste
 Leachates and Seepages
ORD/Municipal  Environmental
Research  Laboratory
Cincinnati,  OH

Mike  H. Roulier
8/684-7871

ORD/Office  of  Exploratory
Research

Donald F. Carey
382-5741
Project  -will   study  the  Wilsonville,   Illinois
hazardous  waste  landfill to determine why organic
contaminants  are  leaking  into  soils  surrounding
the site*

(Medium;   Land)

Nineteen  priority pollutants will  be screened  to
determine  which   pollutants  exhibit  changes   in
adsorption behavior  when various  concentrations  of
humic   and   fulvic   material   are   present   as
background in the  waste  stream»

(Medium:   Land)
 Permeation of Hazardous
 Wastes Through Landfill
 Liners Formulated of Clay
 ORD/Office of Exploratory
 Research

 Donald F *  Carey
 382-7541
Valid  techniques  will  be developed  to  properly
measure   the  permeation   of   leachates   through
geotechnical  materials  commonly used as  permeation
barriers  under controlled  conditions.

(Medium:   Land.)
                                                          46

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WASTE MANAGEMENT/RESOURCE RECOVERY
Title
Office/Division
                                                                      Description
Investigation of Volatile
Organic Chemical Emission
Control Methods for
Hazardous Waste Disposal
Operations
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH
See:  Treatment Technology Development/Evaluation
                                                          47

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EMERGENCY RESPONSE
Title
Office/Division
Description
State and Local Emergency
Response Training
Emergency Response Team
Training
Technical Support for
Superfund Policy
Formulation
Office of Emergency Remedial
Response

Joseph Bahnick
382-7912

Office of Emergency Remedial
Response

Stephen Dorrler
8/340-6740

Office of Emergency Remedial
Response
This  project   will  support  strategic   training
initiatives  to  develop  state  capabilities  for
assuming removal and remedial activities.
This  contract will  provide  technical  and safety
training  for  EPA  and  other  Federal  employees  : s
well  as  develop  new  courses to  meet identified
technical training needs.
See:     Policy
Options
Studies/Regulatory  and   Contr-1
Policy/Analytical Support
For Superfund
Implementation and
Evaluation

Emergency Response Cleanup
Services
Countermeasures Program
Development
Office of Emergency  Remedial
Response
Office of Emergency Remedial
Response

Jim Jowe tt
382-2205

Office of Emergency Remedial
Response

Michael Flaherty
382-2196
See:     Policy   Studies/Regulatory   and  Control
Options
This    contract    provides   cleanup   equipment,
materials, and personnel to conduct CERCLA removal
actions.
This contract  will  provide for the development of
guidelines  for the  prevention of  the  release of
the    CERCLA   hazardous    substances    in   all
environmental media  (land, air and water).

(Media:  Multi-media)
                                                         48

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POLICY STUDIES/REGULATORY AND CONTROL  OPTIONS
Title
Office/Division
                                                                       Description
Support for Development,
Analysis and
Implementation of
Hazardous Waste
Regulations

Post '82 Attainment Policy
Workshops
Analysis and Evaluation of
Environmental Issues in
Region VIII
Office of Solid Waste

Jon Perry
382-4689
Office of Air Quality Planning
and Standards/Control Programs
Development Division
Region VIII

Paul Riederer
8/327-2351
This new  contract will  provide  technical  support
for  the  refinement of  land disposal regulations.
This  will   include  standards   for  liners  and
location guidances.
                        Symposia,   Workshops  and
See:      Conferences,
Training

(Medium:  Air)
The   contractor   provides   economic   analysis,
benefit-cost  analysis,  program  evaluations  and
policy  analyses  in  this  level-of-effort  analytic
resources contract.  Task orders include:

1 .  Assist   Region  VIII   states   in   evaluating
    alternative   funding   mechanisms   for  State
    hazardous waste programs.

2.  Provide   a   seminar  and   documentation  for
    applying  benefit-cost analysis  techniques  to
    evaluating  BACT  alternatives  especially   in
    state-run air pollution control programs.

3.  Inventory acid  rain research efforts  (current
    and  recent)  in  the   six-state  Region VIII
    rocky-mountain  area,  and  assist  Region VIII
    staff in  developing an Acid Rain Strategy  that
    will emphasize subject areas where  research  is
    lacking  and  target geographic  areas   needing
    immediate or near term remediation.

(Medium:  Air)
                                                         49

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POLICY STUDIES/REGULATORY AND CONTROL  OPTIONS
Title
Office/Division
Description
Monitoring Guidelines
Regulations and Strategies
Policy/Analytical  Support
for Superfund
Implementation  and
Evaluation
 Technical Support for
 Superfund Policy
 Formulation
 TSCA Section 8(c)
 Implementation/Evaluation
Office of Air Quality Planning
and Standards/Emission Standards
and Engineering Division

David Lutz
8/629-5651

Office of Emergency  Remedial
Response

Bruce Clemens
382-2201

Office of Emergency  Remedial
Response

Maryann Froelich
382-2207

Office of Toxic  Substances/
Existing Chemicals Assessment
Division

Barbara Ostrow
382-3540
This  contract  will provide  monitoring guidelines
for  criteria  and  noncriteria pollutants.   These
guidelines will assist state  and  local governments
in their siting functions.

(Medium:  Air)

This   contract   will   provide  technical  support
services  to  assist in designing,  implementing and
assessing the effectiveness of CERCLA programs,
This  contract  provides  support  in  delineating,
implementing  and  assessing  policies  related  to
fulfilling responsibilities under CERCLA.
Final   regulations   under   section  8(c)   of   TSCA
require  chemical manufacturers  and processors  to
keep  records  of allegations received  from workers
and  the public  regarding  the chemical  substances
these  companies  produce.  Some  10,000  firms  could
be  affected by  this rule.   Two purposes  in  this
contract   are:     (1)   to   assist  the  Agency  in
developing a  comprehensive,  ongoing  methodology
for  sampling  the section  8(c) records  so that the
Agency can  evaluate  the  kinds  of records  being
kept under the rule and the volume of such records
and  (2) to help the Agency evaluate the effective-
ness  of  the  rule   and  of  company experience  in
implementing it.
                                                          50

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POLICY STUDIES/RBGUIATORY AND CONTROL  OPTIONS
Title
Office/Division
Description
Technical Support Services
for Test Rules Development
Technical Analysis  to
support standard  and
Environmental  Impact
Statement Preparation
Office of Toxic Substances/
Existing Chemicals Assessment
Division

Jeff Davidson
475-81 40
Office  of  Radiation Programs

Lewis Meyer
557-8610
This contract  provides  technical support  services
to  assist  the  test rules   development   process.
These support  services involve extensive data base
searches  and   literature   retrieval  review  and
assessment of  this technical data and literature,
preparation  of  technical  support  documents,  and
public  comment  coordination.    Specific   outputs
include technical  support documents  of publishable
quality of TSCA section 4 testing decisions.

The  contractor provides  technical assistance such
as  cost/benefit  analyses,   model  formulation   to
calculate  risks,  disposal  alternatives  and cost
data,   for   the   preparation   of   a  low-level
radioactive waste  standard.
 Impact of Hazardous and
 Solid  Waste Regulations
 Office of  Emergency Remedial
 Response

 Tom Ingersoll
 475-8115
This  contract  will provide  economic,  regulatory
and environmental  analysis  aimed at the  impact  of
regulations  in the  areas of  solid and  hazardous
wastes.
 Case History and
 Regulatory Support
 Office of Toxic Substances/
 Chemical Control Division

 Robert Jones
 382-3746  .
The  contractor will  query the  technical  document
information  system   to  find  previously  reviewed
cases  that may be similar to cases presently under
review by the  Agency.  The contractor will analyze
cases   significant to  review  of  new  cases  and
develop reports  which  relate previous  regulatory
decisions to  the  current  cases.   For  some cases,
the  contractor will  use  the information  from the
data  system  to   develop  a  case  history  report
taking   into    account   how   other   applicable
regulations  significantly  affect the  cases.
                                                          51

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POLICY STUDIES/REGULATORY AND CONTROL OPTIONS
Title
Office/Division
                                                                       Description
Residue Chemistry
Farm  Safety
 Regulatory Reform
 The Role of Local
 Government in Hazardous
 Waste Management
 Policy Analysis for Toxic
 Substances Identification
 and Testing
Office of Pesticide  Programs

William Boodee
557-7484
Office  of  Pesticide Programs

Linda Billings
557-7634

Office  of  Policy Planning and
Evaluation/Office of Standards
and Regulations

Nancy  Beach
 382-7567

 Office of  Solid Waste

 Jane C. Stieber
 382-4505
 Office of Toxic Substances

 Margo Oge
 382-3704
This  contract  will provide  for  the  review  and
evaluation  of  product and  residue chemistry  data
in support of pesticide regulation.

(Chemicals:  Pesticides)

This  contract will provide  support for  guideline
development and training.

(Chemicals:  Pesticides)

This  contract will provide  analytical support in
the  development of new reform opportunities,  the
implementation  of  controlled   trading  policies,
regulatory    outreach,   regulatory    alternative
seminars,  and negotiated  rulemaking.
 The   purpose   of   this  grant  is  to  support  the
 overall  goals  of  EPA  and  the  states  which  are
 assuming   .the   responsibility   for   establishing
 programs  Ainder  the aegis of  RCRA Subtitle  C  and
 Superfund  legislation.

 The  purpose  of this  cooperative agreement  is tc
 articulate and analyze  important  issues in  the
 identification and testing of toxic substances; tc
 synthesize   and   assess   alternative    policies,
 strategies  and   approaches   that  address  these
 issues;    and   to  contribute   to   an   improved
 understanding  of  the processes  by  which  toxic 01
 potentially  toxic substances are  developed,  used
 and released into the environment.
                                                           52

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POLICY STODIES/RBGUIATORY AMD CONTROL OPTIONS
Title
Of fiea/Division
Description
Methods Development in
Measuring Benefits of
Environmental Improvement
Environmental Assessment
of Region I
Development of Improved
Methods for Evaluating the
Impacts of Toxic
Subs tances Regulatory
alternatives on Industry
Organization, Structure,
and Performance

Framework-Case Study
Design for a Risk Benefit
Analysis of a Pesticide in
the Special Review Process
Development and
Application of an Advanced
Utility Simulation Model
Office of Program Planning and
Evaluation

Alan Carlin
382-5754

ORD/Strategic and Scientific
Assessment Staff

John W. Reuss
382-5747

Office of Toxic Substances/
Economics and Technology Division

Dr. Michael Shapiro
382-3667
Office of Program Planning and
Evaluation

Al McGartland
382-3354

Industrial Environmental Research
Laboratory
Research Triangle Park, NC

John O. Milliken
8/629-7716
Research  to  improve  the  methods   for  measuring
economic  benefits  of  environmental improvements
will   be   developed   under   this  cooperative
agreement.
The  purpose  of  this  cooperative  agreement  is  to
analyze  current  and  future  environmental trends,
problems and opportunities in Region I.
This project will provide  for applied research and
demonstration  activities   which  would  lead  to
improved  methods   for  performing  economic  and
regulatory  analyses  of  Toxic  Substances control
actions.
Methodologies   will  be   developed   under   this
cooperative  agreement  to  improve  and  generate
estimates  of   economic   benefits  and  costs  of
proposed pesticide review decisions.
Researchers  on  several  university  campuses will
provide  expertise  and technical  support  in the
development  of  an  advanced   utility   simulation
model for use  in regulatory policy analysis  under
this assistance agreement.
                                                         53

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POLICY STUDIES/REGULATORY AND CONTROL OPTIONS
Title
Office/Division
Description
fhe Benefits of Hazardous
Waste Management
Regulations Using
Contingent Valuation
Office of Program Planning  and
Evaluation

George Provenzano .
382-5732
This  grant  proposes  to  develop  and demonstrate
improved   contingent    valuation   methods   for
measuring  the   regional   and  national   economic
benefits  of  regulations to  control land  disposal
of hazardous wastes.

(Medium:  Land)
Ihe Use of Time Allocation
Information  in Exposure
Estimation and Economic
Benefits Analysis:   An
Exploratory  Research
Proposal

Develop a National
Aggregate Benefit Estimate
Office  of Program Planning and
Evaluation

Dr. George  Provenzano
382-5732
 Office of  Program Planning and
 Evaluation

 Ralph Luken
 382-5490
The  purpose  of  the  cooperative agreement  is  to
examine the  use  of time allocation information  in
estimating   pollutant   exposures  and   the   health
benefits associated with pollution control.
This  cooperative agreement  will provide  research
to  better  integrate  estimates  of  benefits  from
controlling  individual  pollutants  into  aggregate
estimates  of the benefits  of controlling air  and
water pollution.
                                                          54

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METHODOLOGY DEVELOPMENT/VALIDATION -  TREATMENT PROCESSES AND MONITORING
Title
Office/Division
                                                                       Description
Polychlorinated Biphenyl
Disposal Methods
Development
Office of Toxic Substances/
Exposure Evaluation Division
                                Frederick Kutz
                                Joe Carra
                 382-3569
                 382-3886
This  project will  be oriented  towards  improving
the  Agency's  ability  to  detect  very  hazardous
chemicals  during  PCB  destruction  processes  by
improving   analytical   methods    and  analytical
standards.   Instrumentation,  equipment,   supplies
and   qualified   personnel  will   be  provided  to
conduct  the  laboratory  methods  development  and
standards  development.    There   will  also  be  a.
review    of    existing   analytical    techniquesr
preparation   of    proposals   or    work    plans,
preparation  of   standards   and   preparation  of
reports for work performed under this task*

(Chemicals :  PCBs)
 Health and Environmental
 Data Audit Program (HEDAP)
 Management Assistance
 Malignant Transformation
 of Human Diploid Cells by
 Chemical Carcinogens and
 Mutagens from Residues of
 Drinking Water

 Detection of Somatic Cell
 Mutations in Human
 Erythrocytes by Labeling
 with Antibodies Against
 Glycophorin A
 Office of  Toxic Substances/
 Existing Chemicals Assessment
 Division

 Carl R.  Morris
 475-8148

 ORD/Office of Exploratory
 Research

 Clyde C. Bishop, Jr.
 382-5744

 ORD/Office of Exploratory
 Research

 Clyde C. Bishop
 382-5741
This  contract will provide  a more formal  program
for  coordinating laboratory  inspection and  study
audits  of   industrial/contract   laboratories  whc
develop data for TSCA purposes.   In  addition,  the
contractor  will validate  the  submitted data wit-
approved study plans,

The  goal of  this project is  to develop an in vitro
method    of   human    cell    transformation   by
environmental  chemicals  and  mixtures  that  will be
predictive of malignancy in mammalian  hosts.
This   is   a   laboratory   study   to   develop   a
quantitative   method  for  determining   mutagenic
chemicals using peripheral blood.
                                                          55

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METHODOLOGY DEVELOPMENT/VALIDATION -            PROCESSES  MID MONITORING
Title
Office/Division
                                                                       Description
Rapid Screening Methods
for Genotoxic Chemicals
Organic Chemical Residue
and Pine Particulate
Investigation of Various
Environmental Phenomena
Anaphase Aberration - A
Unifying Method for
Development of an Aquatic
Animal Gene-tox Model
Validation of Analytical
Methodology for
Implementation of EPA
Regulations on Pesticides
ORD/Office of Exploratory
Research

Clyde C. Bishop
382-5744

Research Laboratory/ORD
Duluth, MN

Philip Cook
8/783-9550

ORD/Office of Exploratory
Research

Rufus Morison
382-5741

Office of Pesticides Programs

Kenneth F* Kissler
344-2232
The  objective of  this  project  is  to  develop a
rapid in  vitro mamalian  cell  screening assay  for
detecting  the ntutagenic/earcinogenic  activity of
toxic chemicals.
The  purpose of  this  assistance amendment  is to
design  short-term  tests  for  assessing  relative
biological and carcinogenicity  of unknown^ complex
mineral dust samples *
This project will use  the cytogenetic  technique of
anaphase aberration  analysis to  link  and compare
genotoxic effects  or  organic  compounds  on cells,
embryos and whole animals of the same species.
This cooperative agreement will provide EPA with a
mechanism  for  validation and  publication  of an
analytical  methodology for  implementation of EPA
regulations pertaining to pesticides.

(Chemicals:  Pesticides)
Evaluation of Proposed
Test Protocols to
Determine Toxicant
Leaching into Potable
Water
Methods for Assessing the
Impact of Environmental
Chemicals in Hunan
Fertility
ORD/Municipal Environmental
Research Laboratory
Cincinnati, OH

Alan A. Stevens
8/684-7342
ORD/Office of Exploratory
Research
This  cooperative  agreement will  develop tank and
pipe   coating   material   testing   protocol   to
determine coating  component leaching into potable
water.     Field   verification   of   validity  of
protocol,

(Medium;  Water)

See:  Health Effects
                                                         56

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METHODOLOGY DEVELOPMENT/VALIDATION - TREATMENT PROCESSES AND MONITORING
Title
Office/Division
Description
Aquatic Toxicology:
Testing and Evaluation
ORD/Environmental Research
Laboratory
Duluth, MN
See:-  Environmental Effects
                                                         57

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MODELING
Title
Of f ic e/Divi s io n
                                                                       Description
Control Strategies
"Modeling Clearinghouse"
Evaluate Complex Terrain
Models
 Extrapolation  of  Animal
 Data  for Assessing Ozone
 Risks
 Math  Models Testing
 Handbook on Pollutant
 Modeling
Office of Air  Quality Planning
and Standards/Control Programs
Development Division

Brock Nicholson
8/629-5516
Office  of  Air  Quality Planning
and Standards/Monitoring and Data
Analysis Division

William M. Cox
8/629-5561
 Office of Air Quality Planning
 and Standards/Strategies and Air
 Standards Division

 Dave McKee
 629-5655

 ORD/Environmental Research
 Laboratory—Athens,  GA

 Heinz Kollig
 8/250-3447

 ORD/Environmental Research
 Labora to ry—Athens,  GA

 Thomas Barnwell
 8/250-3175
This  ' Clearinghouse   provides   advice   on  State
Implementation  Plans,   bubble  rules,   technical
issues   of   modeling   and   volatile   organics
compounds«

(Chemicals;  Volatile Organic Compounds)
(Medium;  Air)

The  contractor  provides  statistical performance
evaluations  of  each  of  eight complex  terrain
models  using model  predictions   and  measure  data
collected  at  two  field  sampling networks.    The
performance   statistics   are  archived  on  EPA's
computer and used by  scientists  in conducting  peer
review of models used for regulatory purposes.

(Medium;  Air)

The  objective  of  this contract  is to apply  actual
animal  data  to  a quantitative, dosemetric model
and   apply   the  model   to   the   standard   setting
process.
This   new   contract   will   provide   analytical
chemistry  and   biology  laboratory  sampling  and
preparation for  the  testing of math models.
 This   basic  'ordering   agreement  will  provide  a
 critical   review  of   a  handbook  on   pollutant
 modeling     which   will    cover    conventional'
 pollutants.   This manual will serve as a state-of-
 the-art reference on  fate and  transport  and  will
 emphasize  process descriptions and  rate  constants.

 (Chemicals:   Conventional Pollutants)
                                                          58

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MODELING
Title
Office/Division
Description
Demonstrate and Evaluate
the Environmental Problem
Anticipatory System  (EPAS)
Mathematical Models  for
Subsurface Transport and
Fate
ORD/Strategic and  Scientific
Assessment Staff

John W.  Reuss
382-5747

ORD/Robert S. Kerr Environmental
Research Laboratory
Ada, OK

Carl G.  Enfield
8/743-2334
The  purpose  of  this  cooperative  agreement  is  to
provide  a   systematic  and   consistent  set   of-
qualitative   and   quantitative   indicators    of
changing enviromental trends and conditions.
Documentation  and  implementation  of  contaminant
transport  models  complete with  codes  and user-
guides,  as   well  as  preparation  of  a   report
detailing the  proper  application  of the models  tc
practical  field   situations,  will  be developed
under this cooperative agreement»

(Mediums  Ground water)
Facilitation  of General
Unders tanding and
Application of Ground
Water Models
 QED/Emrironmental Research
 Laboratory
 Ada,  OK

 Joseph F. Keely, Jr.
 8/332-8800
The  purpose of  this cooperative  agreement is  to
facilitate  the  understanding and  application  of
ground-water  models  and  their  accessibility  to
potential users»

(Medium:  Ground water)
                                                          59

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DATA BASE DEVELOPMENT
Title
Of fice/Pivi sion
Description
Biodegradability Data Base
Development
Office of Toxic Substances/
Exposure Evaluation Division

Robert Boethling
382-3913
Industrial Data Index
De ve 1opment

State/Local Toxics Program
Support Initial Design of
Clearinghouse
Office of Toxic Substances/
Economics and Technology Division

Office of Mr Quality Planning
and Standards/Strategies and Air
Standards Division

Karen Blanchard
8/629-5519
This  project   provides   for  development  of  an
Environmental  Fate . Data  Base  which  includes  a
large amount  of biodegradability  data indexed by
chemical.    Laboratory  methods  used  to  measure
biodegradation  will be  reviewed.   This  data will
be evaluated and categorized,  with respect to each
chemical,  to  indicate the  ease of biodegradation
in different environmental  situations.  Structure-
activity   relationships   of  chemicals  that  are
associated  with  biodegradability  will  also  -be
evaluated.

See:  Industry Studies
This    contract   provides    support    for   the
establishment of a clearinghouse, coordinated with
STAPPA   and   ALAPCO   to   facilitate   information
exchange   on   air   toxics   issues•     Proposed
clearinghouse contents include:

     Source permitting data
  -  Air toxics programs descriptions
  -  Proposed ambient limits for chemicals
  -  EPA reports and lists of ongoing research
  -  Clearinghouse newsletter
                                                         60

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SAMPLING, ANALYSIS AND MONITORING/GENERAL
Title
Office/Division
Description
Indoor Mr Pollution
Membrane-Covered Rotating
Disk Electrode
Development of a Sensitive
Assay System for
Monitoring Viral
Pesticides
ORD/Industrial Environmental
Research Laboratory
Research Triangle Park,  NC

David Sanchez
8/629-2979
ORD/Office of Exploratory
Research

Louis Swaby
382-5741

ORD/Office of Exploratory
Research

Rufus Morison
382-5744
This  contract provides  for  the  establishment of
the  status  of  the  research done  on  indoor air
quality  measurement.   Information  regarding the
nature    of    pollution     sources,  '  pollutant
characteristics   and  control  options   will  be
assessed.   This  will be an update on the research
done in the past three years.

(Medium:  Air)

This grant  agreement will develop an electrode to
measure toxic metal species in the environment.
The  purpose  of  this  assistance amendment  is  to
prepare monoclonal  antibodies to the Tussock  Moth
polyhedrosis  virus  (TM  - NPV)  pesticide.    These
would be  employed  in a  radioimmune  assay for use
in studying, the  antigenic structure of NPV/s, for
monitoring  the  application of pesticides, and for
following its physical fate in the environment,

(Chemical:  Pesticides)
                                                          61

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SAMPLING, ANALYSIS AND MONITORING/GENERAL
Title
Office/Division
Description
Efficiency of Soil Core
and Soil-Pore Liquid
Sampling Systems
Development  and  Testing  of
Protocol  for Selecting
Principal Hazardous
Constituents in  Waste
Stream
 Investigation of Volatile
 Contaminants in the
 Unsaturated Zone Above TCE
 Polluted Ground Water
ORD/Robert S. Kerr Environmental
Research Laboratory
Ada, OK

Fred M. Pfeffer
8/743-2305
 ORD/Robert S®  Kerr Environmental
 Research Laboratory
 Ada,  OK

 Thomas  E. Short
 8/743-2234
 ORD/Robert S.  Kerr Environmental
 Research Laboratory
 Ada,  OK

 William J« Dunlap
 8/743-2011
The research will  compare -the abilities of porous
cup   samplers   and  soil   cores   to  detect  the
migration    of    fast-moving    hazardous   waste
constituents  through  soil*    The approach  is  to
study  the  mobility of   at  least  20  fast-moving
organic  constituents in  five  different hazardous
wastes using  undisturbed soils of different types
of large lysimeters,

(Medium;  Land)

Specific  objectives;  1) preliminary  protocol fo •
indicator selection  based on  simulation model  wil .
be   developed,  2)  literature   search  will  t •;
conducted  to  identify  and evaluate  methods   fc :
estimating  necessary model parameters,  3)  TRD  will
be produced and 4)  laboratory experiments will  be
conducted  to  evaluate  the model's  assumptions  to-
test  protocols.

(Medium;  Land)

The  purpose of  this  cooperative agreement is  13
evaluate  the relationship  of  volatile contaminant
distribution   between  the  ground  water  and   tl. =.
vapor phase in soil  above the  water  table.

 (Chemical;   Trichloroethene)
(Medium:  Ground water)
                                                          62

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SAMPLING, ANALYSIS AND MOMITORIliG/GENBRAL
Title
Office/Division
Desc ription
Indoor Air Monitoring
Study
ORD/Office of Monitoring  Systems
and Quality Assurance

Lance Wallace, Ph.D
382-5797
Hospitals of recent construction will be evaluated
to  identify the  generic  materials used  in their
construction.  All buildings monitored by EPA will
be evaluated by a project team  for suitability and
idiosyncratic ventilation features.

(Medium;  Indoor Air)
Identification of
Mutagenic Compounds  in
Wastewater  Effluents and
Sludges
 The  Isolation and
 Identification of
 Electrophilic Mutagens
 Produced  During Chlorine
 Disinfection
 Analytical Facility for
 Hazardous Waste
 Inves tigations
ORD/Health Effects  Research
Laboratory
Cincinnati,  OH

F.  Bernard Daniel
8/684-7482

ORD/Health Effects  Research
Laboratory
Cincinnati,  OH

Frederick C. Kopfler
8/684-7451

ORD/Environmental Monitoring and
Support Laboratory
Las Vegas, NV

J.  Gareth Pearson
8/545-2232  . .
Wastewater    sludge    and   effluents   will   be
fractionated  to  detect  mutagens  thereon  and to
characterize    these    chemicals    under    this
cooperative agreement.

(Medium;  Water)

The  objective of  this cooperative agreement is to
develop   a    system    for    the   isolation   and
identification   of   electrophilic   mutagens   in
drinking water samples.

(Medium;  Drinking Water)

The    design,    development,    production,   and
distribution   of   the  quality control   materials
required  by   the  new  dioxin protocol  will be
developed under this  assistance agreement.

(Chemical:  Dioxin)
                                                          63

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SAMPLING, ANALYSIS AND MONITORING/GENERAL
Title
Office/Division
Description
Development of Specialized
Analytical Techniques for
Characterizing Chlorinated
Dib enz o-p-di oxi ns,
Dibenzofurans, and
Biphenyls
ORD/lnvironmental Monitoring
Systems Laboratory
Las Vegas, NV

G. Wayne Sovocool
8/545-2212
The objectives  are the development of  specialized
techniques for characterizing chlorinated dibenzo-
p-dioxins, dibenzofurans and biphenyls  in order  to
support the EPA's monitoring programs.

(Chemicals; •  Dibenzo-p-dioxins, Dibenzofurans,
              Biphenyls)
                                                         64

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SAMPLING AND MOMITORING—MONITORING/ENVIRONMENTAL
Title
Office/Division
                                                                       Description
State-Regional Technical
Support
Office of Toxic Substances/
Exposure Evaluation Division

William Wood
382-3928
Analytical Services
Contract for Multi-
concentration (low and
medium) Inorganics in All
Media
Region IX

Laura J. Tom
8/454-8379
Air Pollutant Measurement
Me thodologi es
ORD/Environmental Monitoring  and
Systems Laboratory
Research Triangle Park, NC

Seymour S. Hochheiser
8/629-2106
This project  will provide  for  the mutual sharing
of data between States? regions and OTS; technical-
support for state and  regional monitoring studies-,
including  survey   design,   sample  analysis  and
quality  assurance   procedures;   transfer  of  an
atmospheric fate  parameter  estimation  program to
the state  of  Massachusetts? and the establishment
of  a  cooperative  agreement  with  the  state  of
Michigan to  adapt various  environmental  fate and
exposure models  and features  supported  under the
OTS  Graphical Exposure  Modeling   System  to  their
needs.

This new contract will provide analysis of low and
medium concentrated inorganics in  all media.  This
contract parallels the CLP  in  most respects but is
tailored  for  use  by  Region  9   and  allows for
additional technical direction/control.

(Chemicals;  Inorganics)
(Media;  Multi-Media)

This  contract modification  will   provide  for the
evaluation   of   recent    developments   in   the
measurements  of  pollutants  in   ambient  air and
stationary sources,

(Medium:  Air)
                                                         65

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SAMPLING fiND MONITORING—MONITORING/ENVIRONMENTAL
Title
Office/Division
Description
Chemical Analytical
Services for 2,3,7,8-
te trachlorocU.be rizo
(dioxin)
The Indicator Approach  to
Toxic Chemical  Sites
Lang-Term Measurements  of
Trace Chemicals  in the
Troposphere
Office of Emergency  Remedial
Response

Fred Haeberer
382-7906
ORD/Environmental  Monitoring
Systems  Laboratory
Las Vegas,  NV

George T.  Flatman
8/545-2100

ORD/Office of Exploratory
Research

Robert Papetti
382-5741
This  contract will  provide  for the  analysis  of
soil/sediment  samples  to  detect and  measure  the
presence and concentration of Dioxin.

(Chemicals;  2,3,7,8-Tetrachlorodibenzo
             (Dioxin))
(Medium:  Land)

This     project     will    apply    nonparametric
geostatistics  to monitoring data which is  censored
on  the lower  values  (BDL) .    This  will give  Eore
statistically  robust  methods  for  analyzing  and
monitoring data.
Bi-weekly   measurements   of   atmospheric   trace
chemical  constituents  will  be  made  under  this
grant»   The study will characterize  the  long-term
growth  and changes  in  atmospheric abundance  of  a
large group of man-made and natural chemicals.

(Medium:  Mr)
                                                          66

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SAMPLING, ANALYSIS MTD MOHITORING/CHEMICAL  ANALYSIS—SPECIFIC TOPICS
Title
Office/Division
 Description
Operation of Regulated
High Hazard Laboratory-
Regulated High  Hazard
Laboratory
PCB and  Toxaphene:
Preparation of  Analytical
Standards
 Evaluation of
 Volatilization of
 Hazardous  Constituents at
 Hazardous  Waste Land
 Treatment  Sites
 An Evaluation of the
 Protocol for Dnsaturated
 Zone Monitoring at Land
 Treatment Sites
Office of Emergency  Environmental
Response

Stan Kovell
8/382-7906
Office  of  Enforcement Council
Denver, CO

Dr« Ted Meiggs
8/234-4661

ORD/Large  Lakes Research
Laboratory
Grosse  lie,  MI

Michael D. Mullin
8/226-7811
 ORD/Environmental Research
 Laboratory
 Ada,  OK

 Fred  M. Pfeffer
 8/743-2011
 Robert S. Kerr Environmental
 Research Laboratory
 Ada,  OK

 Donald H. Kampbell
 8/743-2011
The   laboratory    converts    samples    that  .are
considered  to be potentially  hazardous to a  form
that  can  be analyzed  in an' ordinary  laboratory
environment.     The  majority  of  work  is   for
superfund.   The  regulated laboratories are located
at NEIC Denver, and EMSL, Las  Vegas.

'The  contract will  provide  for the preparation  of
potentially   highly  hazardous  samples   for   the
Superfund  program  so  that   they  can  be  safely
tested in a  normal  laboratory.
The  purpose of  this cooperative  agreement  is  to
(1)  provide improved synthesis and purification of
a  number of the  PCB isomers? (2) synthesize larger
amounts  of  15 congeners  identified  previously  as
toxicj  and  (3)  develop separation  procedures  for
the  purification of  toxaphene  congeners.

(Chemicals; PCB's,  Toxaphene)

This project will evaluate and verify air sampling
procedures  and a volatilization model developed by
Thibodeaux  and  Hwang for  the  air  emission release
rates  of organics from  land  treatment sites.

(Chemicals; Organics 5
(Medium: Land)

The  research  will  be  designed  to  determine  the
number of samples and sampling frequency necessary
to  adequately   measure   downward   movement   of
hazardous waste  components through the unsaturated
zone of  soils at land treatment facilities.

{Medium;  Land)
                                                          67

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CONFERENCES, SYMPOSIA, WORKSHOPS AND TRAINING
Title
Of fie e/Divi sion
Description
Development and Revision
of Courses and Course
Materials for Mr
Pollution Training
Hazardous Waste Treatment
and Storage Facility
Emission Workshop
Symposium on Air Pollutant
Measurement Methodologies
Workshops on Toxicity
Assessment Issues
Workshop on Progression of
Heoplasia
Office of Air Quality Planning
and Standards, Control Program
Development Division
Research Triangle Park, NC

Ron Townsend
8/629-2401
ORD/Industrial Environmental
Research Laboratory
Cincinnati, OH

Edwin T. Oppelt
8/684-7696

ORD/Environmental Monitoring  and
Systems Laboratory—
Research Triangle Parlp, NC

Seymour Hochheiser
8/629-2106

ORD/Office of Health ^nd
Environmental Assessment—
Cincinnati, OH

Linda Erdreich
8/684-7572           [

Office of Toxic Substances/
Health and Environmental Review
Division

Harry Milraan
382-4292
This contract will  develop new courses and revise
existing courses on air pollution for training of
state  and  local  agencies' personnel  and others.
Three  types  of  self-study  packages  are  being
developed:   1) self-instructional courses, some of
which   include    slides   and   audio   tapes;   2)
correspondence courses;  and 3) slide/tape courses.

{Medium;  Air)

This workshop will  provide planning, organization
and  personnel  for  a workshop on  hazardous waste
treatment,   storage  and  disposal  facility  air
emissions.

(Media;  Land, Mr)

This symposium  will  focus  on the recent advances
in  the  measurements  of  pollutants  in ambient air
and  stationary  sources.   It  is  scheduled for May
1984.
This   project   will  provide   for  workshops   on
toxicity  assessment issues  methodologies.    Issue
papers  on systemic toxicity  and complex mixtures
will be reviewed.
This workshop  will cover the histopathogenesis  of
neoplasia  (the  progression of  neoplasms  from the
benign  to  the  preneoplastic  to  the  neoplastic
phase) in specific tissues.
                                                         68

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CONFERENCES, SYMPOSIA, WORKSHOPS AND  TRAINING
Title
Office/Division
Description
Post  '82 Attainment Policy
Workshops
Phthalate Acid Esters
Conference
Office of Air Quality Planning
and Standards/Control Programs
Development Division

David Stonefield
8/629-5540
Office of Toxic Substances/
Existing Chemical Assessment
Division

Laurence Rosenstein
475-8163
This contract  will provide  a  summary of comments
and questions made by Regional Office personnel. on
a  Post-'82   Attainment  Policy  Workshop.     The
summary will be  used  to develop  a supplemental
document  to  distribute  to  Regional Offices  and
State Agencies.

(Medium!  Air)

This request will provide partial  funding  for an
International Conference  on  Phthalate Acid Esters
currently   scheduled    for   August   1984,     The
conference  will  focus  upon {1)  the  results  of
ongoing   testing,   (2)   current    theories   of
carcinogenesis   as  applicable   to  plasticizers
(epigenetic  versus  non*-epigenetic)  and  (3)  the
national  and international  regulatory  status  of
the phthalates.

(Chemicals:  Phthalate Acid Esters)
Technical Assistance
Program—Asbestos in
Buildings (Training)
Wastewater Sludge Workshop
Office of Toxic
Substances/Chemical Control
Division

Richard McAllister
382-3952
ORD/Health and Environmental
Assessment
Research Triangle Park, NC

F. Bernard Daniel
8/684-7482
This contract  will provide training materials and
a  training  program for  State  and local  officials
on   control    of   friable    asbestos-containing
materials in  buildings.   This  will  enable state
and  local  officials  to  respond to  requests for
assistance  from  building  owners  in  cooperation
with the ten Regional Asbestos Coordinators.

(Chemical:  Asbestos)

This new  contract will provide  for a workshop  on
the  qualitative   and   quantitative   aspects   of
organic   chemical   pollutants   in    wastewater
sludge.   The   workshop  was  held  January  10-12,
1984.

(Chemicals;   Organics)
(Medium:  Water)
                                                         69

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STATISTICAL STUDIES
Title
Office/Division
Description
Air Quality, Emission and
Monitoring Trends and
Reports
Acid Deposition  Study
 University  Academic
 Statistical Support

 University  Academic
 Information Management
 Support

 American Statistical
 Association - Statistical
 Support
Office of Air  Quality Planning
and Standards

Neil Frank
8/629-5558

ORD/Environmental  Monitoring
Systems  Laboratory
Research Triangle  Park,  NC

Peter L. Finkelstein
8/629-2347

Office  of Program  Planning and
Evaluation/Office  of Standards
and Regulations

Phil  Ross
382-2683
This contract provides statistical support for the
study  of  monitoring,  emissions  and  air  quality
trends.

(Medium;  Air)

This  new  contract will  provide  for  statistical
methods   research  for   the  analyses   of   acid
deposition data.

(Medium:  Acid Rain)
All  three  contracts  mentioned   are  part  of  the
Statistical  Policy  Staff's  effort  to  expand  its
technical   and    support    capabilities.       The
Statistical   Contract  Management  System,   under
which  these  contracts  fall,  will help the  Agency
improve  the  quality  of its  statistical  data  and
analyses.    The  expertise  available  are  in  the
following areas:

      sample survey design
   -  sampling methods
   -  statistical  modeling
   -  collection of  data
      data processing
   -  statistical  programming
      data analysis
                                                          70

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                                                i   Chemical  Index

                                                i
Chemical                                                                       Page

2-Acetylaminofluorene (53-96-3)                                                10
2-Aminofluorene (153-78-6)                                .                     10
Acetaldehyde (75-07-0)                                                         10,  31
Acrolein (107-02-8)                             I                               31
Acrylonitrile (107-13-1)                                                       31
Allyl Chloride (107-05-1)                                                      31
Aluminum (7429-90-5)                                                           19
Ammonia (7664-41-7)                                                            6
Arsenic (7440-38-2)                                                            32,  41
Asbestos (1332-21-4)                                                           69
Atrazine (1912-24-9)                                                           20
Barium (7440-39-3)                                                             37
Benzene (71-43-2)                               ,                               16,  28
Benzo(a)pyrene (56-55-3)                                                       10
Benzyl Chloride (98-88-4)                                                      31
Biphenyls  (92-52-4)                                                            64
Bis(Chloromethyl)Ether  (111-44-4)                                              31
Butadiene  (106-99-0)                                                           10
Cadmium (7440-43-9)                                                            32
Carbon Tetrachloride  (56-23-5)                                                 31
Chloramine  (127-65-1)                                                          16
Chlorine (7782-50-5)                                                           16
Chlorine Dioxide (7790-93-4)                                                   16
Chlorobenzenes (108-90-7)                       ,                               1, 31
Chloroform (67-66-3)                   ,                                        31
Chloromethylmethyl  Ether  (107-30-2)                                            31
Chloroprene (126-99-8)                     •                                    31
Chromic acid (1333-82-0)                                                       28
Conventional Pollutants                                                        58
o-, m-, p-Cresol (95-48-7,  106-44-5,,  108-39-4)                                32
Cyclophosphamide (50-18-0)                                                     10
Dibenzo-p-dioxins  (1746-01-6)                                                  64
Dibenzofurans  (SEQ:76)                                                         64
p-Dichlorobenzene  (25321-22-6)                                                 32
Diethylinitrosamine (55-18-5)                                                  6
Difuroxanthone-type alkylatlng  agents                                          12

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Cheaical
                                                                               Bage
Dimethylnitrosamine (62-75-9)                                                  10'  32
4,6-Dinitro-o-cresol (534-52-1)                                                39
Dioxane (123-91-1)                                                             32
Dioxins Isomers (SEQ:128)                                                      1' 25'  34'  42'  63
Endrin (72-20-8)                                                               1 3
Epichlorohydrin (106-89-8)                                                     32
Ethanes (74-84-0)                                                              16
Ether (SEQ:21)                                                                 28
Ethylene Dibromide (106-93-4)                                                  32
Ethylene Bichloride (107-06-2)                                                 32
Ethylene Oxide  (75-21-8)                                                       32
Fluoride (16984-48-8)                                                          41
Formaldehyde  (50-00-0)                                                         24' 25'
Formalin (50-00-0)                                                             28
Glyoxal (107-22-2)                                                             1°
Hazardous Air Pollutants
Hepatotoxins  containing anthraquinone nucules  (84-65-1)                        12
Hexachlorocyclopentadiene  (77-47-4)
Industrially  used  lipid chemicals  of plant origin                              12
                  ,                                                             65
Inorganic compounds
Lead  (7439-92-1)                                                            .    ^'    '
Lindane (58-89-9)                                                              JT
MDA (101-79-9)
Malathion  (121-75-5)
Maleic Anhydride  (108-31-6)
Manganese  (7439-96-5)                                                           *'
Methyl Chloroform (71-55-6)
Methyl-glyoxal  (107-22-2)
Methyl  Iodide (74-88-4)
Methylene  chloride (75-09-2)
N-methyl-N'-Nitro-N-Nitrosoguanidine (70-25-7)
Methyl Parathion (298-00-0)
Nickel  (7440-02-0)
Nitrate (14797-55-8)                                                            32
Nitrobenzene (98-95-3)                                                f         32
 2-Nitropropane (79-46-9)
Nitrosamine congener  alkylazonyl-methanol-derived alkylating agents            ^
N-Nitrosodiethylamine (55-18-5)
 Nitrosoethylurea (759-73-9)
 Nitrosomethylurea (684-93-5)                                                   32
 Nitrosomorpholine (59-89-2)
                                                                                32



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Chemical
Page
Oligomeric residues
Organic compounds
Organic N-chloramines
Ozone (10025-15-6)
Paints
Particulates
Perchloroethylene (127-18-4)
Peroxyacylnitrate
Pesticides

Phenol (108-95-2)
Phosgene (75-44-5)
Phthalate Acid Esters (SEQ:31)
Polychlorinated biphenyls (PCB's) (13336-36-3)
Polycyclic aromatic hydrocarbons (PAH's)  (SEQ:6)
Polynuclear lactone alkylating agents
Propylene Oxide (75-56-9)
Pyrolizidine derivative alkylating agents
Radium (7440-14-4)
Safrole and its congeners (94-59-7)
Selenium (7782-49-2)
Solvents
Styrene (100-42-5)
Sulfates (14808-79-8)
Tannins C1401-55-4) and Flavonoids
2,3,7,8-Tetrachlorodibenzo-(Dioxin)  (1746-01-6)
Toluene (108-88-3)
Toxaphene (8001-35-2)
Trichloroethylene (79-01-6)
Triethyltin (997-50-2)
Trihalomethane (SEQ:2.8)
Vinyl carbamate (15805-73-9)
Vinylidene chloride (75-35-4)
Volatile Organic Compounds  (VOCs)
Water soluble high polymers
o-, m-, p-Xylene (95-47-6,  108-38-3, 106-42-3)
17, 67
44, 69
17
31
24
31
32
10
1, 12, 15, 24, 25, 34, 35, 38, 52,
56, 61
16, 32
1, 32
69
1, 6, 9, 24, 32, 36, 39, 55, 67
6
12
32
12
37
12
41
24
10
31
12
28, 66
10, 32
67
32, 62
15
38, 39, 40
10
1 , 32
24, 38, 40, 58
12
32

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                                       Industries/Industrial Processes Index
                                                                              Page


Alfalfa Dehydrating                                                            33
Aluminum Products                                                              33
Ammonia                                                                        34
Animal Feed Defluorination                                                     33
Biotechnology                                                                  23
Brick and Related Clay Products                                                34
Castable Refractory                                                            34
Ceramic Clay                                                                   34
Coal Gasification                             •                                 33
Copper Mining/Processing                                                       33
Crude Oil and Natural Gas Production                                           33
Detergent                                                                      33
Electric Arc Furnace Operations                                                33
Explosives                                                                     33
Fabric Printing                                                                33
Fiberglass                                                                     33
Foundries:  Steel                                                              33
Gasoline Additives                                                             33
Geothermal Energy                                                              33
Gypsum                                                                         33
Hazardous Waste Disposal                                                       43
Hydrogen Fluoride                                                              33
Incineration and other combustion sources                                      25
Incineration:  Organic Liquid Wastes                                           33
Industrial Surface Coating                                                     33
Mineral Wool                                                                   33
Municipal Incinerators                                                         33
Oil Shale                                                                      33
Organic Chemical                                                               30
Perlite                                                                        33

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                                                                               Page

Phosphoric Acid                                        .                         33
Plywood Manufacturing                                                           33
Polymers and Resins                                                             33
Printing Ink                                                                    33
Rubber Products                                                                 33
Secondary Zinc                                                                  33
Sintering:  Clay and Flyash                                                     33
Starch                                                                          34
Synthetic Fibers                                                                33
Synthetic/Organic Chemical Manufacturing Industries                             33
Uranium Refining                                                                33
Utility Steam Generators                                                        33
Varnish                                                                         33

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                                                   Sfedia Index
    I
                                                                            Page
       <^&

Acid-rain                                                                    21, 22, 40, 70

Air      .                                                                    1, 11, 31, 34, 43, 49,  50,  58,  61,
     :-; ; '>  ''.'.                                                                 65, 66, 68, 69, 70
     * . ' ,• •-.
Drinkinfg 'Water                                                               16, 17, 38, 39, 40, 63

Ground Water                                                                 1,3, 4, 37, 38, 59,  62

Indoor Air                                                                   63

Land                                     '                                    1, 2, 3, 36, 40, 42,  44,  45,  46,
                                                                             54, 62, 66, 67, 68

Multi-Media                                                                  21, 35, 48, 65

Water                                                                        2, 11, 19, 20, 39, 44,  56,  63,  69

-------