EPA/600/R-13/237
                                                                                             September 2013
xvEPA
United States
Environmental Protection
Agency
Ground  Water Issue
      Ground Water Issue Paper: Synthesis Report on State of
        Understanding of Chlorinated Solvent Transformation
               Bruce Pivetz, Ann Keeley*, Eric Weber, Jim Weaver, John Wilson, and Cissy Ma
                Contents
 1. Objectives and Scope                      1
 2. Introduction                           2
  2.1  MNA                              2
  2.2  Site Characterization and Conceptual Site Model.       2
  2.3  Physical and Chemical Properties of the Contaminants.    2
  2.4  Contaminant Transport and Physical Attenuation Processes 4
  2.5  Geochemical Conditions.                    5
  2.6  Contaminant Natural Attenuation Rates            6
 3. Biotic Chlorinated Solvent Transformation Pathways
   and Processes                          7
  3.1  Introduction to BioticTransformations             7
  3.2  PCEandTCE                          9
  3.3  TCA                               24
  3.4  Dioxane                             25
 4. Abiotic Transformations                    27
  4.1  PCEandTCE                          29
  4.2  TCA                               33
  4.3  Dioxane                             35
 5. Summary of Biotic and Abiotic Transformations      35
 6. Modeling applications and conceptualizations for
   chlorinated solvent transformations             37
  6.1  Historical Background                      37
  6.2  Types of Models                        37
  6.3  Parameter Measurement in the Field             38
  6.4  Model Application                        38
 7. References                             41
                Figures
  Figure 1.1. Elements of a conceptual site model for monitored
  natural attenuation.                         3
  Figure 3.1. Bacterial species involved in dechlorination
  processes.                              23
  Figure 3.2. Enzymes involved in dechlorination processes.     23
  Figure 4.1. Formation of abiotic reductants as a function of iron
  and sulphate reducing zones.                    29
  Figure 4.2. Reaction Scheme illustrating the degradation
  pathways for PCE.                          30
  Figure 4.3. Reaction scheme illustrating the degradation
  pathways for TCA                          34
                 Tables
  Table 1. Contaminant physical and chemical properties.       4
  Table 2a. Microbial Metabolic Processes               8
  Table 2b. Reactions and Subsurface Conditions            8
  Table 3a. Compilation of compilations of chlorinated solvent    11
  Table 3b. Chlorinated solvent biotic transformation         21
  Table 4.1. Surface area-normalized rate constants          31
* Corresponding author: National Risk Management Research
   Laboratory, U.S. Environmental Protection Agency, 919
   Kerr Research Drive, Ada, OK 74820, USA
   Tel.: 1.580.436.8890 fax: 1.580.436.8614
   Email: keeley.ann@epa.gov (A. Keeley)
                            1.  OBJECTIVES AND SCOPE
                            Chlorinated solvents are altered by biotic and abiotic processes.
                            Biotic transformation can include reductive dechlorination,
                            cometabolism, and limited oxidation.  Abiotic transformation
                            is less well understood but may play a role at some sites.
                            Transformations may be limited such that endpoints fall short of
                            complete degradation of the solvent to innocuous compounds.
                            Determination of which endpoints are reached, the processes of
                            transformation, and the needed site data are critical for assessing
                            and modeling transport, and deciding on monitored natural
                            attenuation (MNA) as a remedy.
                            This Issue Paper summarizes the biotic and abiotic transformations
                            of several important chlorinated solvents. It briefly describes the
                            factors that affect the transformation mechanisms, as well as the
                            measurements necessary to distinguish among the mechanisms. It
                            serves as a guide for developing an advanced ground-water transport
                            model, with governing equations for simulating these processes
                            in models.  The primary audience is the EPA remedial project
                            managers (RPMs). The Issue Paper is intended to provide RPMs
                            with a basic understanding of the fundamentals and terminology of
                            chlorinated solvent transformation in the context of MNA.
                            The focus of this document is on three chlorinated solvents
                            used at industrial and dry-cleaning facilities: tetrachloroethene
                            (PCE), trichloroethene (TCE), and 1,1,1-trichloroethane
                            (TCA).  It also discusses their degradation ("daughter") products:
                            1,2-dichloroethene (DCE) [primarily r»-l,2-dichloroethene (cis-
                            DCE)], vinyl chloride (VC), 1,1-dichloroethene (1,1-DCE),
                            1,1-dichloroethane (1,1-DCA), and chloroethane (CA). It also
                            covers 1,4-dioxane (dioxane), which is present as a stabilizer in
                            some chlorinated solvent preparations [it was primarily used to
                            stabilize TCA (Mohr 2001)]. These chlorinated solvents are among
                            the most commonly encountered contaminants at many of the
                            worst contaminated sites, and PCE is the primary contaminant
                            found at dry-cleaner sites. TCE is also found at dry-cleaner  sites
                            as a degradation product of PCE, and as the initial contaminant at
                            older dry cleaning sites as it was the dry-cleaning agent used for a
                            few decades starting about 1930.

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  2.  INTRODUCTION
  Understanding and modeling the fate (transformation)
  and transport of chlorinated solvents at contaminated
  sites, as well as their remediation through the
  use of MNA, requires a thorough recognition of
  transformation processes to form a strong foundation
  for conceptual modeling. This introductory section
  presents brief discussions of these topics.
  2.1 MNA
  The U.S. EPA (1999) provided clarification of its
  policy on the application of MNA as a remedy for
  contaminated sites, and defines this alternative as
  "the reliance on  natural attenuation processes (within
  the context of a carefully controlled and monitored site
  cleanup approach) to achieve site-specific remediation
  objectives within a time frame that is reasonable
  compared to that offered by other more active methods".
  Natural attenuation (NA) processes that degrade
  or destroy contaminants are preferred over other
  processes (e.g.,  dilution and volatilization) that merely
  attenuate (i.e., diminish contaminant concentrations)
  contaminant mass (U.S. EPA, 1999). By definition,
  MNA does not include the use of any active remedial
  technologies; however, at most sites MNA is very
  likely to be just one component of the overall
  remedial strategy as it may be applied to only certain
  portions of the site, and/or after active technologies
  have been implemented. Thus, when investigating,
  modeling, or evaluating MNA it is imperative to
  take into consideration other remedial activities that
  have previously occurred or are currently taking
  place.  Guidance documents have been used for
  implementing MNA in ground water (Wiedemeier et
  al., 1998, 1999; U.S. EPA, 1999; National Research
  Council, 2000).
  2.2 Site Characterization and Conceptual
      Site Model.
  Information about the subsurface contamination,
  geology, hydrogeology, geochemistry, and microbiology
  collected during site characterization is assembled
  into a conceptual site model (Figure 1.1). The
  conceptual site model (CSM) is "a three-dimensional
  representation that conveys what is known or suspected
  about contamination sources, release mechanisms, and
                       the transport and fate of those contaminants" (U.S. EPA,
                       1999). The elements of site characterization and
                       the process of preparing a CSM for MNA of volatile
                       organic compounds (VOCs; including chlorinated
                       solvents) are described in Pivetz et al. (2012).
                       Defining the plume in three dimensions and
                       understanding the geochemical and microbiological
                       environment are necessary parts of establishing the
                       CSM. Identifying and defining the most significant
                       ground-water and contaminant flow path(s), and
                       quantifying flow velocities, are critical for estimating
                       chlorinated solvent attenuation rates.  Characterization
                       of the subsurface geochemistry is  also important.
                       Microbiological characterization and confirmation
                       of the presence of specific bacterial strains  is likely to
                       be important to fully evaluate MNA for PCE, TCE,
                       TCA, and dioxane, since effective bioattenuation
                       of each of these depends on the presence of specific
                       microbes. Monitoring should be  extensive enough
                       in three dimensions to be able to  understand the
                       differing conditions that are likely to occur in different
                       portions  of the site and plume. Monitoring should
                       be conducted for a long enough period (likely several
                       years) in  order to  estimate rates of attenuation at a
                       given location.
                       Development of the CSM and modeling of the
                       plume migration, attenuation, and duration requires
                       knowledge of physical characteristics of the subsurface,
                       and activities and changes at the site. According to
                       Pivetz et  al. (2012), information related to the ground-
                       water and contaminant velocities, the lithology (which
                       impacts contaminant transport and sorption such as
                       back-diffusion), seasonal changes  impacting ground-
                       water levels, longer-term changes  (e.g., droughts), and
                       the role and impacts of active remedial technologies
                       (especially source removal activities) should be
                       collected during site characterization.
                       2.3 Physical and Chemical Properties of the
                            Contaminants.
                       Table 1 presents the most significant physical
                       and chemical properties, and their values, of the
                       chlorinated solvents that impact the fate and transport
                       of these compounds in the subsurface.  One set of
                       values is provided in the table; however, it  should
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                   Contaminant Source and Source
                         Control Information

            • Location, nature, and history of contaminant releases
             or sources
            • Locations and characlerizalions of sources for
             ground-water contamination [e.g., nonaqueous
             phase liquid (NAPL)]
            • Locations and descriptions of source control and
             other ongoing and proposed remedial actions
                    Geologic and Hydrologic Information

               1 Regional and site geologic and hydrologic settings.
                including controls on ground-water flow
               • Analyses of depositional environments and geologic
                features that may serve as zones of preferential flow or
                barriers to flow, including geometry and physical
                properties  of geologic facies (e.g., texture, porosity, bulk
                density) and their variability
               •Stratigraphy, including thickness and lateral continuity
                of geologic units, and bedding features
               'Anthropogenic features (e.g., buried corridors and
                heterogeneous fill materials) that control ground-water
                flow, and may serve as migration pathways or barriers
               1 Depth lo ground water and temporal variation

               • Characteristics of surface water bodies (e.g.. locations,
                depths, and flow rates), their interactions with ground
                water, and temporal variations
               1 Ground-water recharge and discharge locations, rates
                and temporal variability
               • Hydraulic gradients, including horizontal and vertical
                components, and their variations in response to
                fluctuations in site hydrology (e.g., seasonal or longer
                term precipitation patterns and changes in patterns of
                ground-water withdrawal or irrigation)
               p Hydraulic properties (e.g., hydraulic conductivities,
                storage properties, and effective porosities) and their
                variability and anisotropy within geologic units
               • Quantitative description of the ground-water flow field
               p Chemical properties of the subsurface matrix including
                mineralogy and organic matter
             Receptor Information

• Aquifer classification, current usage information, and
 reasonably anticipated future usage
• Locations and production data for water-supply wells
• Locations and information on human and ecological
 receptors under current and reasonably anticipated
 future conditions
•Areas susceptible to impact by vapor-phase
 contaminants (e.g.. indoor air)
1 Information on local historical and cultural uses of land,
 water, and older resources used lo identify receptor
 populations
• Descriptions of institutional controls currently in place
             Contaminant Distribution, Transport and Fate

             • Distribution of each contaminant phase (i.e., gaseous,
              aqueous, sorbed, NAPL) and estimates of mass
             • Mobility of contaminants in each phase
             • Temporal trends  in contaminant mass and
              concentrations
             • Sorption information, Including retardation factors,
              sorption mechanics, and controls
             • Contaminant attenuation processes and rate estimates
             • Assessment of facilitated transport mechanisms (e.g.,
              complexation or colloidal  transport)
             • Geochemieal characteristics that affect or are indicative
              of contaminant transport and fate, and mineralogy, if
              needed
             1 Potential for mobilization of secondary contaminants
              (e.g., arsenic)
             • Effects of other proposed or ongoing remedial
              activities on contaminant transport, fate, and natural
              attenuation processes
 Figure 1.1.    Elements of a conceptual site model for monitored natural attenuation.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatic
                                            jnd Water Issue     3

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Table 1. Contaminant physical and chemical properties.
Properties:
Molecular
weight
(g mole"1)
Water
solubility
at 25 °C
(mgL-1)
Contaminant
density
as a NAPL
(gmL-1)
Log soil/water
partition
coefficient
(Log Kow)
Vapor
pressure
at 20 or 25 °C
[mm Hg)
Henry's Law
Constant
at 25 °C
(atm m3 mol"1)
PCE1
C2CI4
(CI2C=CCI2)

165.83

150

1.6227
3.40


18.47

1.8x 10'2
TCE1
C2HCI3
(HCIC=CCI2)

131.4

1070

1.465
2.42


74

1.1 x10'2
Cis-DCE1
C2H2CI2
(HCIC=CCIH)

96.95

3500

1.2837
1.86


180

4.08 x10'3
vc1
C2H3CI
(H2C=CCIH)

62.5

2763

0.9106
1.36


2530

2.78 x10'2
TCA1
CI3CH3
(CCI3CH3)

133.4

1500

1.3390
2.49


124

6.3 x10'3
1,1 -DCA1
C2H4CI2
(HCI2C-CH3)

98.97

5500

1.1747
1.79


1.82

4.4 x10'2
CA1
C2H5CI
(CH3-CH2-CI)

64.52

5740

0.9214
1.43


1008

1.11 X10-2
Dioxane1'2
(C4H802)

88.11

Miscible

1.0329
-0.27


38.1

5x 10'6
References
  1ATSDR: Toxicological Profiles for each compound
  2Mahendra and Alvarez-Cohen (2006)
 be noted that the values of these properties can vary,
 depending on the conditions and how the values were
 measured.
 2.4 Contaminant Transport and Physical
      Attenuation Processes
 The attenuation of contaminant concentrations
 with time and distance from a source area (i.e.,
 natural attenuation) can be due to "a variety of
 physical, chemical, or biological processes that...
 include biodegradation; dispersion; dilution; sorption;
 volatilization; radioactive decay; and chemical or
 biological stabilization, transformation, or destruction
 of contaminants" (U.S. EPA, 1999).  Detailed
 discussion of these processes can be found in the
 following contaminant hydrogeology reference
 books: Freeze and Cherry (1979), Fetter (1993),
                       and Domenico and Schwartz (1998). This
                       document focuses on the destructive processes:
                       biotic transformations (biodegradation) and abiotic
                       transformations (degradation through chemical
                       reactions). However, confirming and quantifying the
                       impacts of these destructive processes (and calculation
                       and understanding of attenuation rates) requires an
                       understanding of how the other, non-destructive,
                       processes impact the site and the data collected for
                       the MNA evaluation.  All of the contaminants in this
                       document are subject to advection, dispersion, and
                       dilution.  Chlorinated solvent concentrations will be
                       relatively low in ground water due to a low solubility.
                       Dioxane, however, is miscible with water, meaning
                       ground-water concentrations can be quite high.  This
                       means that sorption will be negligible for dioxane,
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 whereas, the chlorinated solvent contaminants will
 be slightly to moderately sorbed. Volatilization from
 shallow ground water can occur with the chlorinated
 solvents; however, volatilization is unimportant for
 dioxane due to its very low Henry's Law constant.
 None of these contaminants are subject to radioactive
 decay. All of these contaminant fate and transport
 processes and properties need to be recognized and
 quantified in order to model contaminant ground-
 water migration and to  quantify the effectiveness
 of NA. This includes understanding the relative
 significance of each of the processes.
 2.5 Geochemical Conditions.
 Biotic and abiotic transformations of the chlorinated
 solvents will be influenced by the subsurface soil and
 ground-water geochemical conditions, which may vary
 with time and location.  Most significantly, which
 oxidation-reduction (redox) reactions occur in the
 subsurface will determine whether or not a particular
 contaminant is transformed, and the extent and rate
 of its transformation. Identification of different zones
 of different redox conditions and processes will help
 indicate where particular transformations are or are
 not occurring.  The main redox reactions  (terminal e"
 accepting processes, or TEAPs), their final or terminal
 e" acceptors (TEAs), and their reaction products that
 occur or are found in the subsurface are:
    • Aerobic respiration: the TEA is oxygen (O2), and
      CO2 is produced.
    • Nitrate  reduction (denitrification): the  TEA is
      nitrate (NO3"), and N2 is produced.
    • Manganese reduction: the TEA is manganese(IV)
      (Mn+4), and manganese(II) (Mn+2) is produced.
    • Iron(III) reduction: the TEA is iron(III) (Fe+3), and
      iron(II) (Fe+2) is produced.
    • Sulfate reduction: the TEA is sulfate (SO42"), and
      hydrogen sulfide (H2S)  is  produced.
    • Methanogenesis: the TEA is carbon dioxide (CO2),
      and methane (CH4) is produced.
 The TEAPs generally occur in the order given above.
 After dissolved oxygen is depleted and the subsurface
 becomes anaerobic, the TEAPs shift to denitrification,
 then iron(III) reduction and sulfate reduction, and
 ultimately to methanogenesis. However, although one
TEAP may be relatively predominant, several of the
TEAPs may occur simultaneously in close proximity
to each other. The occurrence of any one given TEAP
depends on the supply of the terminal e" acceptor and
the appropriate microbial community.
As discussed below in section 3.1.1, the bacteria
that biodegrade chlorinated solvents obtain their
energy during microbiologically mediated oxidation-
reduction reactions in which electrons transfer
between compounds that act as electron (e") donors
(co-contaminants or naturally occurring carbon)
and e" acceptors (the chlorinated solvents).  This
reductive dechlorination (which is a major anaerobic
biodegradation pathway for chlorinated solvents) uses
the chlorinated  solvents as e" acceptors. Its  occurrence
and rate varies depending on the geochemical
conditions brought about during the TEAPs discussed
above, as well as whether the requisite microbes for
dechlorination use the chlorinated solvents  or the
TEAs as their e" acceptors.
The predominant redox condition and zone (i.e.,
correlating to a specific microbial TEAP)  can also be
identified through subsurface dissolved hydrogen (H2)
measurements (Lovley et al. 1994),  as indicated by the
following ranges:
    •  Denitrification:         <0.1 nM H2
    •  Iron(III) reduction:     0.2 - 0.8 nM H2
    •  Sulfate reduction:       1-4 nM H2
    •  Methanogenesis:        5-20 nM H2
Measurement of the TEAs and/or their reduced
products in ground water can indicate what processes
are occurring. Relevant or potentially important
geochemical parameters include soil total organic
carbon (TOC);  dissolved organic carbon  (DOC);
oxidation-reduction potential (ORP); dissolved
oxygen; (DO); nitrate; manganese (Mn(II)/Mn(IV);
iron (Fe(II)/Fe(III); sulfate; hydrogen sulfide;  carbon
dioxide; (CO2); methane, ethane, and ethene;
dissolved hydrogen; pH; alkalinity;  temperature;
conductivity; additional  major ions  such as  Ca2+,
Mg2+, K+, Na+, C1-, CO32-, and HCO3-; minerals
present; and concentrations of metals and
metalloids.  Not all these parameters will  need to be
measured nor will be useful in many cases.  Specific
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                          Ground Water Issue   5

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geochemical parameters are discussed below for
individual chlorinated solvents when relevant to the
transformation.
In summary, the biotic transformation of the
chlorinated solvents occurs in the subsurface
geochemical environment developed under several
different terminal e" accepting processes that occur in a
general sequence of aerobic oxidation, denitrification,
iron(III) reduction, sulfate reduction, and then
methanogenesis. However, several TEAPs may be
active at one time within  the same general subsurface
volume, the predominant TEAP may shift with time,
or a given TEAP may not occur. The occurrence
and significance of a given TEAP depends on the
availability of the relevant electron acceptor.
2.6 Contaminant Natural Attenuation Rates
Calculating the rate of contaminant attenuation in a
ground-water plume is important for evaluating plume
migration and the time frame to reach a remedial
goal.  For MNA, attenuation (and contaminant
biodegradation) is often described as a first-order  decay
process (i.e., first-order kinetics; exponential decay):

 C(t) = C0eM   where  C(t) = concentration at time t [M L'3]
                      C0 = initial concentration [M L"3]
                      k = rate constant [T"1]
                      t  = time [T]

The rate of degradation is given by:

 9C/9t =-kC   where  9C/9t is the change in concentration
                    at time t

The rate constant (k) is a  critical parameter in
mathematically modeling fate and transport of a
plume.  Rate  constants for a given process (e.g.,
biodegradation) are often determined under laboratory
conditions, although in NA it is important to
determine the rate constant under site-specific field
conditions. Rate constant values are sometimes
described in terms of half-lives, since they are related
through:
 t1/2 = 0.693/k   where    t1/2 is the half-life [T]

                      k = first-order rate constant [T"1]
                                                      The overall attenuation rate (i.e., rate constant)
                                                      representing all transport and attenuation processes at
                                                      a single point, or along the entire migration pathway
                                                      of the plume, can be calculated using contaminant
                                                      concentration data from a sufficient number of
                                                      monitoring wells that are properly located in the
                                                      migration pathway of the plume. Attenuation
                                                      of the source material must also be understood,
                                                      as contaminant influx into the plume from the
                                                      source area affects the longevity of the plume.  The
                                                      biodegradation attenuation rate can also be calculated,
                                                      which represents the contaminant destructive loss
                                                      due only to biological activity. Further discussion of
                                                      attenuation rates and methods for their calculation
                                                      are  provided in Suarez and Rifai (1999) and Newell
                                                      et al. (2002). It should be noted that other kinetic
                                                      models (e.g., zero order or second order) may be
                                                      used to better describe biodegradation or other
                                                      transformations of contaminants. Monod kinetics,
                                                      as well as the Michaelis-Menten rate law model, is
                                                      often used to describe laboratory biodegradation data,
                                                      and a variety of kinetic parameters for these kinetics
                                                      are  determined.  Chapelle et al. (2007) discuss the
                                                      mathematical treatment of the biotransformation sink
                                                      term and kinetics, including substrate and electron
                                                      (e") acceptor utilization as described by Monod
                                                      kinetics. Alvarez-Cohen and Speitel (2001) provide a
                                                      comprehensive discussion of the kinetics involved in
                                                      aerobic cometabolism of chlorinated solvents.
                                                      Biodegradation and plume attenuation rates (and rate
                                                      constants) have been determined from both laboratory
                                                      and field studies at contaminated sites.  Literature
                                                      compilations of rates and rate constants from
                                                      numerous sites often do not provide the entire set of
                                                      related geochemical, hydrogeological, microbiological,
                                                      and anthropogenic conditions, so it may be difficult
                                                      to fully understand the conditions that impacted the
                                                      rates. Studies where rates and rate constants have been
                                                      calculated at chlorinated solvent sites may not have
                                                      been published in the peer-reviewed literature, rather,
                                                      in gray literature such as site remediation reports.
                                                      Laboratory biodegradation rates should be viewed
                                                      with caution, as they generally represent much more
                                                      optimum conditions than found in the field.
                                                      Modeling the potential for NA processes to
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 successfully remediate a chlorinated solvent site
 depends strongly on knowledge of the rate of biotic
 transformation of the solvent(s). Biodegradation rates
 and/or rate constants can be calculated from site-
 specific measurements, or estimated using previous
 knowledge and experience as reflected in the NA
 literature.

 3. BIOTIC CHLORINATED SOLVENT
    TRANSFORMATION  PATHWAYS AND
    PROCESSES
 3.1 Introduction to Biotic Transformations
 3.1.1  Biodegradation
 In situ biodegradation of chlorinated  solvents (i.e.,
 biotic transformations) is due primarily to subsurface
 bacteria (fungi-mediated biodegradation that may
 occur in the unsaturated zone will not occur in the
 saturated conditions of ground water). For growth,
 bacteria require a carbon source and energy (as well as
 water and mineral nutrients) from a substrate(s) (i.e.,
 the compound(s) providing the carbon and/or energy).
 Heterotrophic bacteria (the majority of bacteria) that
 biodegrade chlorinated solvents obtain their carbon
 from either naturally occurring compounds or other
 contaminants.  The energy is obtained from the
 energy released during microbiologically mediated
 oxidation-reduction reactions in which electrons
 transfer between compounds that act  as e" donors and
 e" acceptors. The e" acceptors can be dissolved oxygen
 (O2), some naturally occurring inorganic compounds
 (NO3-, Mn+4, Fe+3,  SO42-, CO2), or some chlorinated
 solvents. In growth-supporting biodegradation, the
 contaminant is used as a primary substrate by the
 bacteria. Complete biodegradation of the contaminant
 to CO2 is termed mineralization.  Contaminants
 may also be biodegraded through cometabolism, in
 which the degradation is non-growth-supporting for
 the bacteria bringing about the transformation (the
 degradation of the contaminant occurs as a fortuitous
 event as the bacteria use some other substrate and the
 appropriate enzymes are induced). It is important to
 realize that a transformation of a contaminant  to an
 end product often involves  a number  of intermediate
 compounds and types of reactions, some of which
 may not be identified and/or have short persistence.
Reductive dechlorination of PCE and TCE does not
involve any persistent or significant intermediates
before the daughter products  DCE and VC are
formed.
Early research on biodegradation of chlorinated
solvents was published by Vogel et al. (1987), Vogel
and McCarty (1987), Sims et al. (1991), Bouwer
(1993), McCarty and Semprini (1993), and Vogel
(1993).  MNA microbial processes were discussed
in Azadpour-Keeley et al. (1999), a comprehensive
examination of MNA of petroleum hydrocarbons
and chlorinated solvents is found in Wiedemeier et
al. (1999), and a comprehensive review of chlorinated
solvent MNA is found in Rifai et al. (2001).  More
recent reviews of subsurface biodegradation of
VOCs under intrinsic conditions include Field and
Sierra-Alvarez (2004), Lawrence (2006), Aulenta et
al. (2006), Chapelle et al. (2007), and Bradley and
Chapelle (2010).
The literature frequently group chlorinated solvents
biotransformation in a variety of ways: (a) based
on the chemical reaction involved, (b) whether the
contaminant was reduced or oxidized, (c) whether or
not a chlorine was removed, (d) whether the subsurface
conditions were aerobic or anaerobic, (e) whether the
subsurface conditions were oxidizing or reducing, or
(f) by the microbiological metabolic process involved.
Since the same degradative phenomenon may be
referred to in different ways by different practitioners,
it is useful to review and understand the varied
terminology, as well as the basic microbial processes.
Table 2a indicates the biotic transformations of the
contaminants, categorized by the microbial processes
that occur. Table 2b also indicates these biotic
transformations, but categorized by the reactions that
occur. A detailed discussion  of relevant terminology
in provided in Bradley and Chapelle (2010).  The
broad term "reductive dechlorination" as commonly
used in MNA literature is usually meant to signify
only the specific microbially-mediated process (via
halorespiration, also known as chlororespiration)
resulting in removal of one chloride ion from the
chlorinated compound under anaerobic (reducing)
conditions and its replacement by a hydrogen atom.
However, as indicated by Table 2a and b,  other
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Table 2a. Microbial Metabolic Processes Involved in Biotic Transformations of the Chlorinated Solvents.

A. Contaminant as primary substrate:
Growth-supporting.
1. Halorespiration: Anaerobic (anoxic); reductive
dechlorination driven by H2 as an electron donor;
chlorinated solvent used as electron acceptor;
halogen removed (dehalogenation).
2. Respiration/Oxidation: Contaminant used as
electron donor.
a. Oxic respiration: Direct aerobic oxidation.
Oxygen is the terminal electron acceptor.
b. Anoxic respiration: Direct anaerobic oxidation
Inorganic ions other than oxygen are the terminal
electron acceptors.
B. Cometabolism: Non-growth supporting;
contaminant fortuitously degraded with the presence
of another, primary, substrate.
1. Aerobic cometabolism, Cometabolic
oxidation, or Cooxidation: An oxidation reaction;
not a significant naturally occurring process in the
subsurface.
2. Anaerobic cometabolism: A reductive
dechlorination (for the chlorinated solvents); occurs,
but an uncommon and/or slow occurrence; the more
effective anaerobic reductive dechlorination via
halorespiration is not cometabolic.
PCE

Yes

No
No

No

Yes


TCE

Yes

No
No

Yes

Yes


DCE

Yes

Yes
Yes

Yes

Yes


VC

Yes

Yes
Yes

Yes

Yes


TCA

Yes

No
No

Yes

Yes


1,1 -DCA

Yes

Yes
No

Yes

Yes


CA

No

Yes
No

Yes

No


Dioxane

NA

Yes
Maybe

Yes

No


Table 2b. Reactions and Subsurface Conditions Involved in Biotic Transformations of the Chlorinated Solvents.

A. Aerobic oxidation:
a. Direct aerobic oxidation: Oxic respiration.
Oxygen is the terminal electron acceptor.
b. Indirect aerobic oxidation: Aerobic
cometabolism. An oxidation reaction; not a
significant naturally occurring process in the
subsurface.
B. Anaerobic oxidation: Anoxic respiration.
Inorganic ions other than oxygen are the terminal
electron acceptors.
C. Anaerobic reduction: Reductive dechlorination
1. Halorespiration: Anaerobic (anoxic); reductive
dechlorination driven by H2 as an electron donor;
chlorinated solvent used as electron acceptor;
halogen removed; growth-supporting.
2. Anaerobic cometabolism: A reductive
dechlorination, but an uncommon and/or slow
occurrence; the more effective anaerobic reductive
dechlorination via halorespiration is not cometabolic
PCE

No

No
No

Yes

Yes

TCE

No

Yes
No

Yes

Yes

DCE

Yes

Yes
Yes

Yes

Yes

VC

Yes

Yes
Yes

Yes

Yes

TCA

No

Yes
No

Yes

Yes

1,1 -DCA

Yes

Yes
No

Yes

Yes

CA

Yes

Yes
No

No

No

Dioxane

Yes

No
Maybe

NA

NA

8   Ground Water Issu
mthesis Report on State of Understanding of Chlorinated Solvent Transformation

-------
3. Hydrogenolysis: A biotic and abiotic anaerobic
reductive reaction; substitution of a hydrogen
atom for chlorine on the molecule; a reductive
dechlorination; halogens removed (for chlorinated
solvents). When hydrogenolysis is thought of in
terms of being strictly an abiotic reaction, it is likely,
however, to depend on the presence of microbes
to create the conditions conducive to the reaction
(Wiedemeier et al., 1999).
3a. Biotic hydrogenolysis
3b. Abiotic hydrogenolysis
4. Dihaloelimination (dichloroelimination): An
anaerobic reductive reaction; removal of two
adjacent halogen atoms, leaving a double bond
between the respective carbon atoms (forming
an alkene from an alkane); halogens removed
(dehalogenation); a reductive dechlorination. When
dihaloelimination is thought of in terms of being
strictly an abiotic reaction, it is likely, however, to
depend on the presence of microbes to create the
conditions conducive to the reaction (Wiedemeier et
al., 1999).









Yes
Maybe





Maybe














Yes
Maybe





Maybe














Yes





















Yes





















Yes
Maybe





Maybe














Yes
Yes










































NA
NA





NA





 microbial processes and chemical reactions can also be
 reductive dechlorinations.
 3.1.2 General Factors Influencing Subsurface
      Biodegradation and NA
 Subsurface microbes catalyze redox reactions in ground
 water which alters the redox potential and impacts
 the occurrence and rate of biotic transformations of
 contaminants.
 Under anaerobic environments, reducing compounds,
 such as organic carbon, are fermented to produce
 H2 which serves as e" donor for Dehalococcoides
 and other dechlorinating  bacteria (Duhamel et
 al., 2002). Research has demonstrated that under
 strongly reducing conditions in the presence of
 sufficient supply of bioavailable natural organic
 carbon, complete reductive  dechlorination of PCE was
 observed (Thomas et al., 2013). Therefore, dissolved
 H2 concentrations could also be measured and used
 to indicate the predominant microbially catalyzed
 redox reactions and conditions in anoxic ground water
 (Lovley et al.,  1994). There may be competition for
 H2 or other electron donor, or for electron acceptor,
 between different microbial species carrying out
 one or more of these processes, which can affect the
 occurrence and extent of contaminant transformation
 by a particular species.
The concentration of a target contaminant can also
impact the occurrence and rate of biodegradation. At
high enough concentrations, the contaminant may
be toxic to the microbes that degrade it, and low
concentrations may be insufficient to support growth
of the microbe.  A co-existing contaminant may be
toxic or detrimental to a biodegradative process carried
out by specific bacteria.
At some sites, PCE, TCE, and TCA may be present as
a dense  non-aqueous phase liquid (DNAPL) that acts
as a continual source of dissolved solvent as it dissolves
into the ground water. High dissolved concentrations
resulting from dissolution of the DNAPL contaminant
constituent may inhibit or prevent biodegradation.
The presence of a source, and especially DNAPL,
impacts the determination of attenuation rate
constants, and the source decay needs to be considered
(Newell et al., 2002).
3.2 PCE and TCE
3.2.1  Processes and pathways
Biotransformation of PCE and TCE is discussed
together, since they share many similar processes
(Table 2a and b).
The major biodegradation route of PCE and TCE is
through reductive dechlorination, a process known
as "halorespiration".  During this growth-supporting
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
                         Ground Water Issue   9

-------
 microbial process, H2 is directly used as an e" donor
 and the chlorinated solvent serve as the e" acceptor.
 The H2 is produced during biodegradation of other
 organic compounds, either naturally occurring organic
 carbon or organic contaminants such as petroleum
 hydrocarbons (Wiedemeier et al., 1999).  PCE or TCE
 loses a chlorine atom and is reduced.  PCE and TCE
 degradation products from reductive dechlorination
 are DCE and the more toxic VC; however, the desired
 end products are ethene, ethane, and ultimately CO2.
 This biotransformation sequence may slow or stop at
 DCE, with build-up of DCE concentrations (known
 as "DCE stall"). In some cases, VC formed from DCE
 may persist, if reducing conditions are not strong
 enough. However, VC is biodegraded under aerobic
 conditions more than the other chlorinated ethenes,
 raising the possibility of its biodegradation as it moves
 downgradient into a more aerobic environment. DCE
 and VC can be biotically transformed through several
 different mechanisms under either aerobic or anaerobic
 conditions (Table  3).
 Relevant coupled redox half reactions (modified from
 Wiedemeier et al.,  1998) for the PCE/TCE reductive
 dechlorination sequence, and associated stoichiometric
 concentration changes are:

 PCE to TCE:   CI2C=CCI2 + H+ + 2e = HCIC=CCI2 + Cl'
                                 1 mg/L-> 0.79 mg/L

 TCE to c-DCE:  HCIC=CCI2 + H+ + 2e = HCIC=CCIH + Cf
                                 1 mg/L-> 0.74 mg/L

 c-DCE to VC:  HCIC=CCIH + H+ + 2e  = HCIC=CH2 + Cf
                                 1 mg/L -> 0.64 mg/L

 VC to ethene:  HCIC=CH2 + H+ + 2e = H2C=CH2 + CI"

 The predominant  biotic transformation of the
 parent compounds PCE and TCE  that occurs and
 that is desirable for remediation through NA is the
 reductive dechlorination sequence  PCE —» TCE —»
 DCE —» VC —» non-toxic end products.  However,
 sufficient electron donors need to be present, along
 with the requisite  microbes. If not, the reductive
 dechlorination sequence will be incomplete and result
 in persistence of one or more of the contaminants.
                       3.2.2 Factors influencing transformation to
                             desired end product
                       The primary factors affecting the transformation of
                       PCE and TCE to innocuous end products (i.e., CO2
                       and Cl"1), and without accumulation of r-DCE and/or
                       VC, are (1) the presence of sufficient e" donor to drive
                       the redox conditions to the most efficient reductive
                       dechlorination processes, and (2) the presence of the
                       microbes necessary for the complete transformation.
                       The predominant redox condition affects the occur-
                       rence, type, and efficiency of the biotransformation
                       reaction which will occur for the chlorinated ethenes.
                       A highly reducing condition may be necessary for
                       efficient reductive dechlorination of VC to ethene.
                       Halorespiration is most efficient under sulfate-
                       reducing and methanogenesis, less efficient under
                       iron-reducing, and questionable under manganese-
                       reducing conditions (Bradley and Chapelle,  2010).
                       Halorespiration does not occur under aerobic or
                       nitrate-reducing conditions  (North Wind, 2003), but
                       TCE reductive dechlorination to cis-DCE can occur
                       under iron-reducing conditions (Bradley and Chapelle,
                       2010). At contaminated sites where either geochemical
                       conditions are not appropriate for complete
                       anaerobic biodegradation of chlorinated ethenes or
                       Dehalococcoides ethenogenes microorganisms capable
                       of carrying out the transformation to ethene are not
                       present, direct aerobic biodegradation of VC offers a
                       remedial solution for persistent VC plumes that are
                       not amenable to the anaerobic process of reductive
                       dechlorination.
                       The final e" donor (H2) for the halorespiration process
                       to occur is produced through fermentation of organic
                       compounds. As discussed earlier, sufficient e" donors
                       must also be available for the redox conditions to reach
                       those in which reductive dechlorination occurs. At
                       many sites, the initial e" donor (from which  the H2
                       ultimately comes from) is not identified, unless there
                       is a petroleum hydrocarbon  (i.e., e" donor) plume
                       commingled with the chlorinated solvent plume.
                       Otherwise, the e" donor may be simply identified as
                       dissolved TOC.
                       The presence of the appropriate microbes, specifically
                       Dehalococcoides ethenogenes (DHC), is required for
10  Ground Water Issu
mthesis Report on State of Understanding of Chlorinated Solvent Transformation

-------
 Table 3a. Compilation of compilations of chlorinated solvent biotic transformation first-order rate constants.
Contaminant: PCE
Type of
Study
Field
Field
Lab
Lab
and
Field
Field
Lab
Field
Lab
Field
Lab
and
Field
Field
Lab
and
Field
Field
Lab
Lab
and
Field
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
Not specified
Anaerobic
Methanogenic
Methanogenic
Sulfate reducing
Sulfate reducing
Anaerobic
Anaerobic
Not specified
All studies
Aerobic
oxidation
Aerobic
oxidation
Aerobic
oxidation
First-Order Rate Constants (day"1)
Min
0.0022

0.0381
0
0.0007
0
0.0035
0

0.0002
0.0000
0
0
0
0
25th
0.0025









0.0005
0


0
Median
0.0030
0.003

0.00186
0.0007
0.0084
0.0041
0.0065


0.0006
0.009


0
75th
0.0047









0.0007
0.079


0.002
Max
0.0066

0.0381
0.071
0.034
0.071
0.0046
0.013

0.0029
0.0027
0.410
0
0.004
0.004
Mean
0.0038



0.0029
0.0265
0.0041
0.0204
0.0029


0.051
0
0.001
0.001
n, number
of studies
3



5
3
2
3
16
36
9
50
3
7
10
Reference
Aziz et al. 2000
Aziz et al. 2000
Aziz et al. 2000
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
Lawrence 2006
Lawrence 2006
Newell et al.
2006
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Notes
Table B-1. Used
Biochlor with
rates from AFCEE
database of 24
sites.
Fable 12. Median
of field values.
Cites Weidemeier
etal. 1999.
Fable 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
Fable 2.1. Update
of Aronson and
Howard 1997.
Table E-12
Table D-12
Table E-12
Table D-12
Fable 15. Mean
of field/in situ
studies. Cites
Aronson and
Howard 1997.
Fable 15. Mean
or range for all
studies. Cites
Aronson and
Howard 1997.
Fable 8. Rate
constants are from
concentration vs.
time at a point.
Table 8
Table 7
Table 7
Table 8
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  11

-------
 Table 3a. continued...
Lab
Field
Lab
Lab
and
Field
Lab
and/or
Field
Lab
and/or
Field
Lab
and/or
Field
Field
Aerobic
cometabolism
Reductive
dechlorination
Reductive
dechlorination
All studies
Reductive
dechlorination:
nitrate-reducing
Reductive
dechlorination:
iron-reducing
Reductive
dechlorination:
methanogenesis
Anaerobic
0
0
0
0


0
0.00019



0.002


0.013




0.004


0.080




0.050


0.147

0.054
0.080
0.410
1.96


0.410
0.0033
0.025
0.010
0.101
1.41
0
0.004
0.100
0.0029
3
13
23
61
3
2
22
16
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Weidemeier et
al. 1999
Table 7
Table 7
Table 7
Table 8
Table 8
Table 8
Table 8
Table 6-7. Mean
is from field/in
situ studies. Min
and max are
"recommended"
rate constants.
Cites Aronson and
Howard 1997.
Contaminant: TCE
Type of
Study
Field
Field
Lab
Lab
and
Field
Field
Lab
Field
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
Not specified
Anaerobic
Methanogenic
Methanogenic
Sulfate reducing
First-Order Rate Constants (day"1)
Min
0.0008

0.0001
0.00082
0.0004
0.0020
0.0001
25th
0.0014






Median
0.0033
0.003

0.0016
0.0006
0.0145
0.0015
75th
0.0066






Max
0.0088

0.3452
0.04
0.0008
0.0400
0.0071
Mean
0.0041



0.0013
0.0170
0.0019
n, number
of studies
10



6
4
10
Reference
Aziz et al. 2000
Aziz et al. 2000
Aziz et al. 2000
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
Notes
Table B-1. Used
Biochlor with
rates fromAFCEE
database of 24
sites.
Table 12. Median
of field values.
Cites Weidemeier
etal. 1999.
Table 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
Table 2.1. Update
of Aronson and
Howard 1997.
Table E-15
Table D-15
Table E-15
12  Ground Water Issu
mthesis Report on State of Understanding of Chlorinated Solvent Transformation

-------
 Table 3a. continued...
Lab
Field
Lab
and
Field
Field
Lab
and
Field
Field
Lab
Lab
and
Field
Field
Lab
Lab
and
Field
Field
Field
Lab
Field
Lab
Lab
and/or
Field
Lab
and/or
Field
Lab
and/or
Field
Sulfate reducing
Anaerobic
Not specified
Not specified
All studies
Aerobic
oxidation
Aerobic
oxidation
Aerobic
oxidation
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
Anaerobic
oxidation
Anaerobic
oxidation
Reductive
dechlorination:
iron-reducing
Reductive
dechlorination:
sulfate-reducing
Reductive
dechlorination:
methanogenesis
0


-0.0010
0

0
0
0.105
0.024
0.024

0
0


0
0.002
0



-0.0001



0


0.2





0.001
0.005
0.001
0.0029


0.0003



0


0.26





0.002
0.008
0.004



0.0007



0.003


0.88





0.004
0.018
0.008
0.0110


0.0016
3.130

0.028
0.028
1.410
1.650
1.650

0.023
3.130


0.011
0.023
0.109
0.0049
0.0025
0.0006

0.173

0.006
0.005
0.948
0.509
0.586

0.003
0.196


0.003
0.011
0.015
7
30
78
13
86
2
10
11
3
14
17
1
32
24


11
7
10
HydroGeoLogic,
Inc. 1999
Lawrence 2006
Lawrence 2006
Newell et al.
2006
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Table D-15
Fable 15. Mean
of field/in situ
studies. Cites
Aronson and
Howard 1997.
Fable 15. Mean
or range for all
studies. Cites
Aronson and
Howard 1997.
Fable 8. Rate
constants are from
concentration vs.
time at a point.
Table 7
Table 7
Table 7
Table 8
Table 7
Table 7
Table 8
Table 7
Table 7
Table 7
Table 7
Table 7
Table 8
Table 8
Table 8
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  13

-------
 Table 3a. continued...
Lab
and/or
Field
Field
Reductive
dechlorination:
mixed
Anaerobic

0.00014







0.0025
0.001
0.0025
2
47
Suarez and Rifai
1999
Weidemeier et
al. 1999
Table 8
Table 6-7. Mean
is from field/in
situ studies. Min
and max are
"recommended"
"ate constants.
Cites Aronson and
Howard 1997.
Contaminant: c;s-DCE
Type of
Study
Lab
Lab
and
Field
Field
Lab
Field
Field
Lab
Biogeochemical
Conditions
Not specified
All studies
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
First-Order Rate Constants (day"1)
Min
0.0086
0
0.281
0.081
0
0
0.001
25th







Median







75th







Max
0.0256
1.960
1.960
0.434
0.008
0.130
0.200
Mean

0.004
0.885
0.187
0
0.002
0.014
n, number
of studies

34
3
2
4
17
8
Reference
Aziz et al. 2000
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Notes
Fable 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
Table 7
Table 7
Table 7
Table 7
Table 7
Table 7
Contaminant: DCE
Type of
Study
Field
Field
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
First-Order Rate Constants (day"1)
Min
0.0003
0.0000
25th
0.0019
0.0000
Median
0.0033
0.0004
75th
0.0060
0.0000
Max
0.0573
0.0005
Mean
0.0096

n, number
of studies
9
2
Reference
Aziz et al. 2000
Newell et al.
2006
Notes
Table B-1 . Used
Biochlor with
"ates from AFCEE
database of 24
sites.
Fable 8. Rate
constants are from
concentration vs.
time at a point.
Contaminant: DCE (not cis)
Type of
Study
Lab
and
Field
Biogeochemical
Conditions
All studies
First-Order Rate Constants (day"1)
Min
0
25th

Median

75th

Max
1.150
Mean
0.149
n, number
of studies
27
Reference
Suarez and Rifai
1999
Notes
Table 7
14  Ground Water Issu
mthesis Report on State of Understanding of Chlorinated Solvent Transformation

-------
 Table 3a. continued...
Field
Lab
Field
Field
Lab
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
0.390
0

0.001
0.010















1.150
0.714

0.006
0.270
0.720
0.196

0.003
0.101
4
4

16
3
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Table 7
Table 7
Table 7
Table 7
Table 7
Contaminant: DCE (all isomers)
Type of
Study
Lab
and
Field
Lab
and
Field
Lab
and
Field
Lab
and/or
Field
Lab
and
Field
Lab
and/or
Field
Biogeochemical
Conditions
All studies
Aerobic
cometabolism
Reductive
dechlorination:
iron-reducing
Reductive
dechlorination:
sulfate-reducing
Reductive
dechlorination:
methanogenesis
Reductive
dechlorination:
mixed
First-Order Rate Constants (day"1)
Min
0
0
0

0.002

25th
0.002
0.081
0.001

0.007

Median
0.004
0.434
0.002

0.016

75th
0.050
0.714
0.003

0.058

Max
1.96
1.96
0.005

0.200

Mean
1.41
0.591
0.002
0.045
0.047
0.001
n, number
of studies
61
13
8
3
8
2
Reference
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Notes
Table 8
Table 8
Table 8
Table 8
Table 8
Table 8
Contaminant: VC
Type of
Study
Field
Field
Lab
Lab
and
Field
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
Not specified
Anaerobic
First-Order Rate Constants (day"1)
Min
0.0011

0.0003
0
25th
0.0016



Median
0.0047
0.0079

0.00405
75th
0.0134



Max
0.0334

0.01
0.0082
Mean
0.0099



n, number
of studies
7



Reference
Aziz et al. 2000
Aziz et al. 2000
Aziz et al. 2000
HydroGeoLogic,
Inc. 1999
Notes
Table B-1 . Used
Biochlor with
"ates from AFCEE
database of 24
sites.
Fable 12. Median
of field values.
Cites Weidemeier
etal. 1999.
Fable 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
Fable 2.1. Update
of Aronson and
Howard 1997.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  15

-------
 Table 3a. continued...
Field
Lab
Field
Lab
Lab
and
Field
Field
Lab
Field
Lab
Lab
and
Field
Field
Field
Lab
Lab
Field
and
Lab
Field
Methanogenic
Methanogenic
Sulfate reducing
Sulfate reducing
All studies
Aerobic
oxidation
Aerobic
oxidation
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
Anaerobic
oxidation
Anaerobic
oxidation:
iron- reducing
Anaerobic
0.0005

0
0.0057
0

0.043
1.500
0.055
0.055
0.001
0
0
0.008
0.001
0.00033




0.005

0.064


0.576




0.008

0.002

0.0008
0.0076
0.051

0.091


1.500




0.012





0.163

0.114


1.960




0.073

0.006

0.0013
0.0082
8.020

0.125
1.960
0.576
8.020
0.009
0.007
0.520
0.120
0.120
0.0072
0.002

0.0008
0.0076
0.518

0.087
1.730
0.316
2.422
0.004
0.003
0.303
0.049
0.042
0.0079
2
0
1
2
27

4
2
2
5
3
4
4
6
7
19
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Inc. 1999
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Inc. 1999
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Inc. 1999
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Inc. 1999
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1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifia
1999
Suarez and Rifia
1999
Weidemeier et
al. 1999
Table E-16
Table D-16
Table E-16
Table D-16
Table 8
Table 7
Table 8
Table 7
Table 7
Table 8
Table 7
Table 7
Table 7
Table 7
Table 8
Table 6-7. Mean
is from field/in
situ studies. Min
and max are
"recommended"
"ate constants.
Cites Aronson and
Howard 1997.
Contaminant: TCA
Type of
Study
Field
Field
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
First-Order Rate Constants (day"1)
Min
0.0044

25th
0.0055

Median
0.0066
0.0159
75th
0.0077

Max
0.0088

Mean
0.0066

n, number
of studies
2

Reference
Aziz et al. 2000
Aziz et al. 2000
Notes
Table B-1 . Used
Biochlor with
-atesfromAFCEE
database of 24
sites.
Fable 12. Median
of field values.
Cites Weidemeier
etal. 1999.
16  Ground Water Issu
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 Table 3a. continued...
Lab
Lab
and
Field
Field
Lab
Field
Lab
Lab
Lab
Lab
Lab
Lab
Lab
Lab
and
Field
Field
Lab
Not specified
Anaerobic
Methanogenic
Methanogenic
Sulfate reducing
Sulfate reducing
Aerobic, 0.1
and 0.5 mg L"1
TCA
Nitrate-
reducing, 0.1
and 0.5 mg L"1
TCA
Sulfate
reducing, 0.1
mg L'1 TCA
Sulfate
reducing, 0.5
mg L1 TCA
Methanogenic,
0.1 mg L'"1 TCA
Methanogenic,
0.5 mg L""1 TCA
Anaerobic
Not specified
Sulfate reducing
0.0099
0
0
0.0034
0
0







0.00355
0.011
0.0065
0.0030
0.0092






0.0099
0.041
0.0
0.015
0.010
0.015


0.0182
0.0065
0.043
0.0064
No biotransformation observed.
No biotransformation observed.




0.239
0.0006
0.0003





0.0007






0.0009






0.0015





0.3013
0.0017

0.0162
0.0035
0.0142
0.0033


0.0013


5
2
3
3
1
1
1
1
1
1
28
6
1
Aziz et al. 2000
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
HydroGeoLogic,
Inc. 1999
Klecka et al.
1999
Klecka et al.
1999
Klecka et al.
1999
Klecka et al.
1999
Klecka et al.
1999
Klecka et al.
1999
Lawrence 2006
Newell et al.
2006
Scheutz et al.
2011
Fable 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
Fable 2.1. Update
of Aronson and
Howard 1997.
Table E-13
Table D-13
Table E-13
Table D-13
Fable 2. Used
field soil and
ground water.
Fable 2. Used
field soil and
ground water.
Fable 2. Used
field soil and
ground water.
Dseudo-first-order
"ate constant.
Fable 2. Used
field soil and
ground water.
Dseudo-first-order
"ate constant.
Fable 2. Used
field soil and
ground water.
Dseudo-first-order
"ate constant.
Fable 2. Used
field soil and
ground water.
Dseudo-first-order
"ate constant.
Fable 15. Mean
or range for all
studies. Cites
Aronson and
Howard 1997.
Fable 8. Rate
constants are from
concentration vs.
time at a point.
Fable 3. Pseudo-
first-order
"ate constant.
1,1-DCAwas end
oroduct.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  17

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 Table 3a. continued...
Lab
Lab
and
Field
Field
Lab
Field
and
Lab
Field
Lab
Field
Field
Lab
Lab
and/or
Field
Lab
and/or
Field
Lab
and/or
Field
Field
Methanogenic
All studies
Aerobic
oxidation
Aerobic
oxidation
Aerobic
oxidation
Aerobic
cometabolism
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
Reductive
dechlorination:
nitrate-reducing
Reductive
dechlorination:
sulfate-reducing
Reductive
dechlorination:
methanogenesis
Anaerobic
0.0038
0

0
0

0

0
0
0

0.003
0.0013

0


0

0.002



0

0.025


0.010


0

0.013



0

0.125


0.195


0

0.038



0

0.880

0.0148
2.330

0.022
0.022

1.180

0.125
2.330
0

2.330
0.01

0.261

0.003
0.002

0.247

0.029
0.551
0
0.010
0.498
0.016
1
47
2
9
11

5

10
21
4
2
17
15
Scheutz et al.
2011
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
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1999
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1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Weidemeier et
al. 1999
Table 3. Pseudo-
first-order
rate constant.
1,1 -DCA was end
product.
Table 8
Table 7
Table 7
Table 8
Table 7
Table 8
Table 7
Table 7
Table 7
Table 8
Table 8
Table 8
Table 6-7. Mean
is from field/in
situ studies. Min
and max are
"recommended"
rate constants.
Cites Aronson and
Howard 1997.
Contaminant: 1,1 -DCA
Type of
Study
Field
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Not specified
First-Order Rate Constants (day"1)
Min
0.0005
0.0044
25th
0.0005

Median
0.0008

75th
0.0019

Max
0.0033
0.0096
Mean
0.0014

n, number
of studies
3

Reference
Aziz et al. 2000
Aziz et al. 2000
Notes
Table B-1 . Used
Biochlor with
rates from AFCEE
database of 24
sites.
Table 12. Range
of laboratory
values. Cites
Weidemeier et al.
1999.
18  Ground Water Issu
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 Table 3a. continued...
Contaminant: DCA (all isomers)
Type of
Study
Lab
and
Field
Lab
Lab
Field
Field
Lab
Field
Field
Biogeochemical
Conditions
All studies
Aerobic
oxidation
Aerobic
cometabolism
Aerobic/
Anaerobic
Reductive
dechlorination
Reductive
dechlorination
Reductive
dechlorination:
sulfate-reducing
Reductive
dechlorination:
methanogenesis
First-Order Rate Constants (day"1)
Min
0

0.014

0
0.028
0

25th
0

0.019



0

Median
0.001

0.047



0

75th
0.014

0.123



0.001

Max
0.131

0.131

0.011
0.044
0.028

Mean
0.017

0.067

0.002
0.036
0.003
0.006
n, number
of studies
25
2
5

16
2
13
3
Reference
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Suarez and Rifai
1999
Notes
Table 8
Table 7
Table 8
Table 7
Table 7
Table 7
Table 8
Table 8
Contaminant: CA
No experiments or results reported.
Contaminant: Dioxane
Type of
Study
Field
Lab
Lab
Biogeochemical
Conditions
Methanogenic,
<15°C, pH 6-8
Aerobic, 4 or
14°C, 50 mg L"1
dioxane
Aerobic, 14°C,
500 |ig L"1
dioxane,
CB1190
bacterial strain
First-Order Rate Constants (day"1)
Min

25th

Median
0
75th

Max

Mean
0
No significant dioxane biodegradation.





0.1
n, number
of studies
1
1
1
Reference
HydroGeoLogic,
Inc. 1999
Lietal. 2010
Lietal. 2010
Notes
Table E-39
Used microcosms
without
oioaugmentation
or substrate
addition, to
simulate natural
attenuation
conditions. High
concentration
simulated source
zone.
Used
microcosms with
bioaugmentation
and substrate
addition. Low
concentration
simulated leading
edge of plume.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  19

-------
 Table 3a. continued...

Lab

Aerobic, 14°C,
500 ug L"1
dioxane, DVS
5a1 bacterial
strain











0.4

1

Li etal. 2010
Used
microcosms with
bioaugmentation
and substrate
addition. Low
concentration
simulated leading
edge of plume.
Notes:
1 . Rows without rate constant data indicate biogeochemical conditions where no data was provided, and are left in for compari-
son to other conditions.
2. Description of biogeochemical conditions is as specific as was reported in the cited Reference.
20  Ground Water Issu
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Table 3b. Chlorinated solvent biotic transformation zero-order rates.
Contaminant: PCE
Type of
Study
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Zero-Order Rate (ug L"1 day"1)
Min
13
25th
288
Median
577
75th
1040
Max
19800
Mean
1863
n, number
of studies
or rates
29
Reference
Suarez and Rifai
1999
Notes
Table 6
Contaminant: TCE
Type of
Study
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Zero-Order Rate (ug L"1 day"1)
Min
314
25th
511
Median
760
75th
1297
Max
7490
Mean
1740
n, number
of studies
or rates
7
Reference
Suarez and Rifai
1999
Notes
Table 6
Contaminant: cis-DCE
Type of
Study
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Zero-Order Rate (ug L"1 day"1)
Min
13
25th
183
Median
511
75th
1318
Max
16958
Mean
1854
n, number
of studies
or rates
18
Reference
Suarez and Rifai
1999
Notes
Table 6
Contaminant: DCE (not cis)
Type of
Study
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Zero-Order Rate (ug L"1 day"1)
Min
9
25th
23
Median
250
75th
1385
Max
3470
Mean
850
n, number
of studies
or rates
8
Reference
Suarez and Rifai
1999
Notes
Table 6
Contaminant: VC
Type of
Study
Lab
Biogeochemical
Conditions
Reductive
dechlorination
Zero-Order Rate (ug L"1 day"1)
Min
2
25th
6
Median
11
75th
75
Max
495
Mean
107
n, number
of studies
or rates
9
Reference
Suarez and Rifai
1999
Notes
Table 6
Contaminant: Dioxane
Type of
Study
Lab
Biogeochemical
Conditions
Aerobic, 14°C,
500 ug L"1
dioxane
Zero-Order Rate (ug L"1 day"1)
Min

25th

Median

75th

Max

Mean
1.4
n, number
of studies
1
Reference
Li etal. 2010
Notes
Used microcosms
without
bioaugmentation
or substrate
addition, to
simulate natural
attenuation
conditions. Low
concentration
simulated leading
edge of plume.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
Ground Water Issue  21

-------
 the complete reductive dechlorination sequence of
 PCE to ethene (Figure A). A detailed discussion of the
 role of DHC is provided by Maymo-Gatell (1997).
 If DHC is not present, other microbes may partially
 dechlorinate the PCE  and/or TCE to DCE and/or
 VC. If yet other appropriate microbes are present, the
 products of the PCE and/or TCE dechlorination (i.e.,
 r-DCE and/or VC) could be further dechlorinated.
 Extreme pH or temperatures out of the range suitable
 for efficient microbial  activity may inhibit PCE and/or
 TCE biotransformation. A pH range of between pH
 5 and 9 has been cited (Wiedemeier et al., 1999) for
 reductive transformation, as a screening measure.
 Co-contaminants or interfering compounds may
 have an inhibiting effect on biotransformation of a
 target chlorinated solvent.  These compounds may
 include solvent stabilizers [e.g., up to about 5%
 1,4-dioxane in TCA, or a large number of compounds
 up to a total of about  1% in TCE (Mohr 2001)].
 During biodegradation of PCE, Aulenta et al. (2006)
 reported that the presence of a co-contaminant
 1,1,2,2-tetrachloroethane (TCA) negatively impacted
 the dechlorination of VC to ethene by DHC species.
 Carbon tetrachloride (CT), but not the TCA, however,
 inhibited PCE and VC biodegradation by the same
 culture, even though it was able to cometabolize both
 CT and TCA (literature cited by Aulenta et al., 2006).
 TCA completely inhibited dechlorination of VC to
 ethene in presence of a TCE-dechlorinating culture
 as reported by Duhamel et al. (2002) and similarly,
 the reductive dechlorination of PCE, TCE, cis-DCE,
 and/or VC was partially or completely inhibited by
 chloroform (CF) with  a  dechlorinating culture related
 to DHC (Duhamel et  al., 2002).
 3.2.3 Geochemical conditions and
       contaminant concentrations (required
       measurements)
 Geochemical conditions (e.g., redox conditions)
 strongly influence which transformation processes
 will occur and to what extent, as discussed above.
 The naturally occurring e" acceptor(s) supply can
 also impact the biotransformation  process due to
 competition with the chlorinated ethene e" acceptor.
 The contaminant concentration may become
 important in terms of microbial toxicity and e"
                       acceptor supply as mentioned in section 3.1.2.
                       Aulenta et al. (2006) identified some PCE- and TCE-
                       dehalorespiring bacterial strains that are inhibited by
                       PCE concentrations over 0.1 to 0.7 mmol L"1.
                       3.2.4 Indicator species - biological (required
                             measurements)
                       Dehalococcoides ethenogenes strain 195 (DHC) is
                       recognized (Maymo-Gatell, 1997; Maymo-Gatell et
                       al., 1999) as being capable of completely degrading
                       PCE to ethene, through the intermediate products
                       TCE, cis-DCE, trans-DCE, VC, and 1,1-DCE.
                       Other Dehalococcoides strains and known microbial
                       consortia (Wiedemeier et al., 1998; and Aulenta et  al.,
                       2006) that are capable of biotransforming portions
                       of the chlorinated ethene degradation sequence
                       are identified in Figure 3.1. Mixed cultures that
                       can reductively dechlorinate DCE and VC  are also
                       described by Bradley and Chapelle (2010).  Molecular
                       biological tools (MBTs) are available to examine
                       the presence of degradative enzymes (tceA,  vcrA,
                       and bvcA) (Figure 3.2).  vcrA activity is required  for
                       complete degradation of PCE to ethene through  an
                       energy yielding pathway.  A combination of tceA and
                       bvcA may lead to complete degradation; however,
                       through cometabolic reactions that are usually slower
                       than that observed for vcrA.  Molecular biological
                       tools are described in depth in ITRC (2011).
                       3.2.5 Rates of transformation
                       The presentation, analysis, and use of
                       biotransformation rate data is complicated  by the
                       manner in which these data are presented in the
                       literature, since the kinetics of chlorinated ethene
                       solvent biotransformation in field and laboratory
                       studies has been described using Monod kinetics,
                       Michaelis-Menten kinetics, zero-order rates, and  by
                       first-order rate  constants (Rifai et al., 2001; Aulenta
                       et al., 2006). Rate information resulting from
                       laboratory microbial degradation experiments may  be
                       described using different parameters than the simple
                       first-order rates and rate constants that can  be derived
                       from field measurements.  Further, summaries of
                       kinetic parameter values from the literature often are
                       not accompanied by a full range of geochemical and
                       hydrogeological parameter values that could help
                       in understanding or modeling MNA at a field site.
22   Ground Water Issu
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                         Microbiology of Reductive
                     Dechlorination of Chloroethenes
                                Can accumulate if requisite
                                bacteria are not present

                                         *  H 2H  HCI H  V
Cl     Cl 2H  HCI Cl     H 2H  HCI H     H 2H  HCI H  *  H 2H  HCI H     H

  C = C      '    C = C   ^'    C = C   ^~\     C = C    /^'   C = C
 /   \    \/N/     /\    \/N
Cl     Cl   \  Cl     Cl  /    Cl     Cl   \  H     Cl      H     H
                PCE
                             TCE
                                        ci5-1.2-DCE
                  Dehalobacter
                  Dehalospirillum
                  Desulfitobacterium
                  Desulfuromonas
                  Dehalococcoides
                                                       vc
                                                                   Ethene
                                some strains of
                                Dehalococcoides
 Figure 3.1.  Bacterial species involved in dechlorination processes.
                      Contaminant Degradation Pathway
                    The reaction is energy yielding, directly benefiting the bacteria

                    The reaction is cometabolic, not directly benefiting the bacteria

                                                            (Source: RITS, Fall 2007)
 Figure 3.2.   Enzymes involved in dechlorination processes.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatic
                                                   Ground Water Issue  23

-------
 Table 3a provides a sample of first-order rate constants
 from a number of literature compilations, as well as
 from some individual studies. Table 3b provides some
 zero-order rates.
 3.2.6 Case studies
 TCE is found at 1034 National Priority List (NPL,
 Superfund) Sites, while PCE  is found at 938 NPL
 sites (ATSDR, 2011).  The great majority of these
 sites where remedial activities have occurred have
 used "active" remedial technologies, rather than
 the "passive" MNA technology. Where MNA has
 been used, it has almost always been a component
 of the overall remedy, in combination with other
 technologies used prior to MNA or for other portions
 of the site. It is difficult to identify many sites where
 MNA has been the sole remedial technology (although
 the 23 PCE, TCE, or TCA sites evaluated by Newell
 et al. (2006), were reported to have not had any other
 remediation or source depletion activities).  For many
 sites, this means that the NA processes may have
 been likely to be impacted by the other activities.
 Nonetheless, there have been numerous sites where
 successful, comprehensive MNA studies have been
 conducted and extensive information obtained on the
 NA processes and rates (whether or not MNA was
 ultimately selected and was successful as a remedy).
 The discussions throughout this document have
 alluded to MNA sites; the references cited can be
 referred to for further information on these studies.
 A sampling of sites includes the Twin Cities Army
 Ammunition Plant  Superfund Site, MN for TCE
 and TCA; Air Force Plant 44, Tucson International
 Airport Area Superfund Site,  Tucson, AZ for TCE
 and TCA; Picatinny Arsenal,  NJ for TCE; Altus AFB,
 Alms, OK for TCE; Plattsburgh AFB, Plattsburgh, NY
 for TCE; Dover AFB Superfund Site, Area 6, Dover,
 DE; Lakehurst NAES Superfund Site, Lakehurst,
 NJ; Moffett Field Superfund  Site, CA; St. Joseph
 Superfund Site, MI; and England AFB, LA.
 3.3 TCA
 3.3.1 Processes and pathways
 Biotic transformation of TCA has many similarities
 with biotic transformation of PCE and TCE.  This
 section focuses on significant differences in processes
 for TCA.
                       The biotransformation processes for TCA are shown
                       in Table 3, with the most significant process being
                       reductive dechlorination via growth-supporting
                       halorespiration (i.e., with TCA as the electron
                       acceptor) (Scheutz et al, 2011).  Under anaerobic
                       methanogenic conditions, TCA is reductively
                       dechlorinated (relatively faster) to 1,1-DCA, which is
                       then dechlorinated (relatively slower) to chloroethane
                       (CA).  Either of the two degradation products can
                       be the end product, depending on the subsurface
                       microbiological and/or geochemical conditions,
                       although CA has been observed to be the most
                       common end product (Scheutz et al., 2011). Some
                       mineralization of each of these compounds may occur,
                       although it is likely to be  minor (Vogel and McCarty,
                       1987;  Scheutz et al., 2011).
                       Aerobic and  anaerobic cometabolic dechlorination of
                       TCA and 1,1-DCA can occur, but are not significant
                       in terms of using MNA as a remedy for TCA (Scheutz
                       et al, 2011).  Direct aerobic oxidation of CA (but not
                       TCA or 1,1-DCA) has been reported (Scheutz et al.,
                       2011).
                       3.3.2  Factors influencing transformation to
                             desired end product
                       The factors affecting the transformation of TCA to
                       innocuous end products (i.e., ethene, or ultimately
                       to CO2 and Cl"), without accumulation of CA are
                       somewhat different than the factors that impact
                       PCE and TCE degradation to those end products.
                       While the presence of sufficient e" donor to drive
                       the subsurface to methanogenic conditions and the
                       appropriate microbes are  necessary for transformation
                       of the  individual contaminant, there is not one sole
                       set of conditions where complete dechlorination of
                       TCA to innocuous end products occurs (as with
                       methanogenic conditions and the presence of DHC
                       for PCE dechlorination).  TCA to CA dechlorination
                       will occur under one set of conditions (methanogenic
                       with the presence of the appropriate Dehalobacter
                       bacteria), while CA will be degraded to the desired end
                       products under a different set of conditions, through
                       aerobic oxidation in the presence of sufficient dissolved
                       oxygen and the appropriate aerobic microbes (Scheutz
                       et al., 2011). Known microbial cultures are unable to
                       completely dechlorinate TCA to ethane (Scheutz et al.,
                       2011).
24   Ground Water Issu
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-------
 The presence of CT and TCA inhibited the
 biotransformation of each other under anaerobic
 methanogenic conditions (Adamson and Parkin,
 1999).
 3.3.3 Geochemical conditions and
      contaminant concentrations (required
      measurements)
 As with PCE and TCE, the redox conditions will
 strongly influence what transformation processes
 will occur and their extent.  Since the TCA reductive
 dechlorination product CA can be aerobically
 oxidized, identification of downgradient zones of
 sufficient dissolved oxygen,  and the  evaluation of the
 migration pathway of the CA, will be important to
 help assure that this degradation product does not
 persist.
 3.3.4 Indicator species - biological (required
      measurements)
 As with PCE and TCE, the presence of suitable
 microbes with the ability to transform TCA is
 necessary, specifically, the appropriate Dehalobacter
 species for the reductive dechlorination of TCA  to 1,1-
 DCA and/or CA.
 3.3.5 Rates of transformation
 TCA halorespiration (and anaerobic cometabolic
 transformation) has been  described  using pseudo-
 first-order kinetics (Scheutz et al., 2011), and with
 Michaelis-Menten model parameters and first-order
 rate constants (Rifai et al., 2001). Table 3a provides a
 sample of first-order rate constants from a number of
 literature compilations, as well as from some individual
 studies. Table 3b provides some zero-order rates.
 3.3.6 Case studies
 TCA is found at 791 NPL Sites  (ATSDR, 2011).
 Many of these sites that have TCA also have PCE and/
 or TCE. One well-studied TCA site is the Twin Cities
 Army Ammunition Plant, MN (e.g., Wilson 2010).
 Scheutz et al. (2011) discuss TCA biotransformation
 under enhanced reductive dechlorination (ERD) at
 18 sites where both TCA  and chloroethenes were
 found, and four sites with just TCA. Although these
 sites used the active remedial technology of ERD, and
 not  MNA, baseline data was collected prior to ERD
 implementation and indicated the potential for some
anaerobic dechlorination of the TCA via NA. Further
information on these, and other sites, can be found
in the cited references and may be available in a web
appendix to this document.
3.4 Dioxane
3.4.1  Processes and pathways
Dioxane biodegradation occurs through oxidation,
under aerobic conditions, in both growth-supporting
(i.e., as primary substrate) and non-growth-supporting
(i.e., cometabolic) processes involving certain
monooxygenase enzymes. Three bacterial strains and
one fungus have been identified that use dioxane for
growth, while a larger number of bacteria and one
fungus have been reported to degrade dioxane in the
presence of an alternate substrate (i.e., non-growth-
supporting; cometabolic) such as methane.  The
dioxane degradation pathway proceeds to complete
mineralization. The initial degradation step is rate-
limiting, with subsequent degradation steps being
fast.  Intermediate degradation products have been
identified (including ethylene glycol); however, these
products  are further degraded and mineralization
ultimately occurs (Mahendra and Alvarez-Cohen,
2006; Mahendra et al., 2007; Mora and Chiang,
2011). This suggests that undesirable degradation
products will not occur or persist.
Dioxane biodegradation in laboratory experiments was
described by Monod kinetics (Mahendra and Alvarez-
Cohen, 2006) and by either zero-order kinetics  for
"natural attenuation" treatment or first order for
bioaugmented treatments (Li et al., 2010), as shown in
Table 3a and b..
3.4.2  Factors influencing transformation to
      desired end product
A variety of bacterial strains were able to use potential
co-contaminants  as growth substrates for the
cometabolism of dioxane under laboratory conditions,
including toluene, tetrahydrofuran (THF),  MTBE,
and methane (Mahendra and Alvarez-Cohen, 2006).
Although acetylene inhibited biodegradation of
dioxane as a growth substrate, after its removal and
when an alternate substrate was supplied, the ability
to biodegrade dioxane was restored (Mahendra and
Alvarez-Cohen, 2006).
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 Li et al. (2010) simulated natural attenuation
 conditions in laboratory microcosms to investigate
 dioxane biodegradation at temperatures (4 and 14 °C)
 that are lower than the typical laboratory conditions
 (>20 °C). They also studied the impact of dioxane
 concentration, using higher concentrations (50 mg L"1)
 to represent a source zone, and lower concentrations
 (500 iig L"1) to represent the leading edge of a
 plume. No significant biodegradation occurred at
 either temperature with the higher 50 mg L"1 dioxane
 concentration.  However, at the lower 500 tig L"1
 dioxane concentration, significant biodegradation
 was observed, with dioxane decreasing from 500 to
 130 iig L"1 in six months.
 3.4.3 Geochemical conditions and
       contaminant concentrations -  required
       measurements
 Dioxane biodegradation occurs under aerobic
 conditions, requiring the presence of molecular oxygen
 (Mahendra and Alvarez-Cohen, 2006), although
 Mohr et al. (2010) cited laboratory studies in one
 investigation that anaerobic biodegradation of dioxane
 occurred under iron-reducing conditions. Field
 measurements and identification of the aerobic and
 anaerobic zones at a site  are likely to indicate where
 dioxane biodegradation is possible.
 A wider variety of microbes are capable of dioxane
 cometabolism than use it as a primary growth substrate
 (Mahendra and Alvarez-Cohen, 2006). Therefore,
 the identification of a primary substrate source, such
 as methane, THF, or other cyclic ethers (Mora and
 Chiang, 2011)  should provide additional supporting
 evidence for the potential occurrence of NA via biotic
 transformation.
 For all the compounds discussed in this document,
 the contaminant concentration at a number of
 longitudinal locations in a plume is an  obvious
 measurement, not only for calculation of attenuation
 rates, but also in terms of potential toxicity issues.
 There appears to be very limited literature on microbial
 toxicity due to high dioxane concentrations; however,
 Li et al. (2010) reported that significant dioxane
 biodegradation occurred at 500 tig L"1, but not at
 50 mg L"1. The number of measurement locations is
 site-specific.
                       3.4.4 Indicator species - required biological
                             measurements
                       Research has suggested that dioxane is biodegraded by
                       Pseudonocardia dioxanivoram CB1190, Pseudonocardia
                       benzenivoram B5, and Rhodococcm strain 219 as a
                       sole source of carbon and energy (Mahendra and
                       Alvarez-Cohen, 2006).  As apparent, only a limited
                       number of microbes are capable of utilizing dioxane
                       as a growth substrate. Thus, the identification of the
                       known dioxane-degrading microbes and even more
                       significantly, confirmation of their monooxygenase
                       enzymatic activity is the most important evidence for
                       potential MNA at a specific site. As indicated earlier,
                       dioxane can also be cometabolized by a larger number
                       of bacterial species, so the identification of those
                       bacteria could be advantageous.
                       3.4.5 Rates of transformation
                       There has been very little investigation, determination,
                       or reporting of dioxane biotic transformation rates
                       under field conditions.  Mohr et al. (2010) summarize
                       laboratory research and present Monod kinetic
                       parameter values for 1,4-dioxane biodegradation,
                       including those in Mahendra and Alvarez-Cohen
                       (2006).
                       A zero-order rate of 1.4 + 0.02 tig L"1 day"1 was
                       calculated for biodegradation of 500  tig L"1  dioxane at
                       14 °C in laboratory microcosms containing soil and
                       ground water from a dioxane-contaminated site, under
                       simulated natural attenuation conditions (i.e., no
                       biostimulation or bioaugmentation) (Li et al., 2010).
                       3.4.6 Case studies
                       Dioxane has not been the primary or sole target for
                       MNA at contaminated sites, and has seldom been
                       included in the  evaluation of MNA at chlorinated
                       solvent sites. The limited literature on dioxane and
                       MNA at contaminated sites is summarized below.
                       3.4.6.1.  Mohr et al. (2010) presented seven
                         case studies of dioxane site investigations and
                         remediation.  MNA does not appear to have been
                         considered for all or most of the sites. Each site had
                         some active remedial technology implemented.  The
                         off-site plume beyond a ground-water extraction
                         system at one site may have been considered for
                         MNA; however, it was believed that any NA would
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   be via dispersion, diffusion, and dilution rather than
   via dioxane transformation.
 3.4.6.2. Biotic NA of a very large dioxane plume at
   a site near Wilmington, NC was hypothesized by
   Chiang et al. (2008).  The dioxane plume was the
   result of releases during chemical manufacturing
   activities at the site; the dioxane was not associated
   with chlorinated solvents. Chiang et al. (2008)
   stated that the results from a calibrated model,
   and dioxane concentration declines observed
   during long-term monitoring, indicated that "the
   rate of dioxane attenuation...cannot be explained
   solely due  to nonbiological and abiotic attenuation
   mechanisms", which suggested that there were
                       oo
   biological "degradation mechanisms that have limited
   the migration rate and size of the plume". They also
   stated that the "extent of negative ORP and ferrous
   iron" correlated with the locations of reduction in
   dioxane concentrations, "suggesting the potential for
   biological attenuation".  However, no direct evidence
   such as intermediate products or presence of
   dioxane-degrading microbes were observed. Jenkins
   et al. (2009) discussed  the weaknesses in Chiang
   et al.'s (2008) use of limited data and modeling
   as the primary evidence of in situ biodegradation,
   concluding that this site was not likely to be a
   good candidate for MNA. The inappropriate or
   premature conclusion that NA via biodegradation
   was occurring at this site indicates the need for a
   robust site characterization and collection of the
   appropriate parameters.
 3.4.6.3. An investigation of NA was conducted for
   a large dilute TCE and 1,4-dioxane plume at the
   Air Force Plant 44, Tucson International Airport
   Area Superfund Site, Tucson, AZ.  Both TCE
   and TCA had been used at the site; however, the
   main contaminants were the TCE (maximum
   of 520 iig L"1) and dioxane (maximum of
   1,110 iig  L"1), which was present due to the use of
   TCA. The site ground water was aerobic, with low
   TOC. The plumes appeared to be shrinking, and
   MNA was considered for part of the site remedial
   strategy (Mora and Chiang, 2011). Pump-and-treat,
   with reinjection of the treated ground water around
   the plume perimeter, was started in 1987 (Chiang
  et al., 2012); thus, the site has an active remedial
  strategy that complicates calculation of dioxane
  attenuation rates due solely to NA.

  Site ground-water samples were tested using stable
  isotope probing (SIP) with 13C-dioxane baited
  bio-traps.  Phospholipid fatty acid analysis (PLFA)
  indicated that 13C was incorporated into microbial
  biomass, detection of 13C in CO2 indicated that
  some dioxane was mineralized, and quantitative real
  time polymerase chain reaction (qPCR) indicated
  the presence of the necessary bacteria and enzymes.
  Enzyme activity probe analysis indicated that the
  necessary toluene oxygenase enzymes were present
  and active.  This was the first field study to directly
  indicate the natural biodegradation of dioxane
  in the context of subsurface NA; however, the
  analyses used in the study were unable to address
  the determination of attenuation rates (Mora and
  Chiang, 201 1; Chiang et al., 2012).


4. ABIOTIC TRANSFORMATIONS
The following discussion provides an overview
of current understanding of the pathways and
geochemical conditions controlling the abiotic
transformation of the contaminants of interest: PCE,
TCE, and 1,1,1 -TCA.  This discussion will not address
1 ,4-dioxane due to the fact that there is no evidence in
the literature indicating that it is susceptible to abiotic
degradation.
The transformation of chlorinated solvents in the
subsurface is inextricably linked to a set of complex
biological, chemical and geochemical processes.
Overall transformation rate constants for chlorinated
solvents represent a contribution from both abiotic
and biological processes:
                     ~~ ^
                        abiotic
Each of the rate constants represents the relative
contribution of degradation processes, which
depending on the chlorinated solvent, can include
both abiotic reduction and hydrolysis.

                 ^abiotic = ^red ~"~ ^hyd
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 The relative contribution of these terms is dependent
 on the inherent reactivity of the chlorinated solvent
 and the geochemical conditions of the aquatic
 ecosystem of interest. The inherent reactivity is a
 reflection of the strength of C-C1 bonds and the
 reactivity of the abiotic reductants and  nucleophiles
 present in the aquatic system of interest.
 As discussed below, the relative contributions  of
 kred and khyd is dependent on the structure of the
 chlorinated solvent.  PCE and TCE, are susceptible to
 only abiotic reduction (i.e., k^^ =  kK^),  where as the
 abiotic degradation 1,1,1 -TCA is susceptible to both
 abiotic reduction and hydrolysis.  The rate constant for
 hydrolysis is dependent on the neutral and acid- and
 base-catalyzed processes described by:

      £hyd = £base [substrate] [OH~] + £n [substrate] +
                  4dd [substrate] [H+]

 Consequently,  based on values for the individual rate
 constants, which can be measured relatively easily
 in the laboratory, and the pH of the reaction system
 of interest, it is a fairly straight forward process to
 calculate the overall hydrolysis rate constant, £hyd.
 The situation for predicting rate constants for abiotic
 reduction is much more challenging, primarily
 due to the fact that numerous abiotic reductants
 may contribute to the overall rate constant, kred,
 the formation and reactivity of which will vary as a
 function of geochemical conditions. Furthermore, our
 knowledge base at this point is dependent primarily
 on laboratory studies  of abiotic model systems and
 anaerobic microcosms designed to mimic naturally
 occurring conditions in the subsurface. The extent to
 which these results studies apply to natural systems not
 fully understood at this time.
 The formation of abiotic reductants in anaerobic
 aquifer systems is the result of the biologically-
                        mediated oxidation of bioavailable organic matter
                        resulting in the reduction of various e" acceptors (e.g.,
                        Fe(III) oxides and sulfate) as described by Terminal
                        Electron Accepting Processes (TEAPs). The resulting
                        redox zones in anaerobic subsurfaces can  be mapped
                        by the measurement of solution phase species (e.g.,
                        Mn2+, Fe2+, H2S and CH4) resulting from reduction
                        of the e" acceptors (Bjerg, Rugge et al. 1995; Chapelle,
                        McMahon et al. 1995; Jeong and Hayes 2007;
                        Himmelheber, Taillefert et al. 2008; Himmelheber,
                        Thomas et al. 2008). Additional information
                        concerning the determination of redox zones in
                        anaerobic aquifers is provided from the measurement
                        of dissolved H2 concentrations  based on a gas stripping
                        procedure (Lovley, Chapelle et al. 1994).  EachTEAP
                        has a H2-utilizing efficiency resulting in characteristic
                        concentrations of dissolved H2  (i.e., < 0.1 nM H2 for
                        Nitrate reducing zones; 0.2 to 0.8 nM H2 for iron
                        reducing zones; Ito 4 nM H2 sulfate reducing zones,
                        and 5 to 15 nM H2 methanogenic (Lovley and
                        Goodwin 1988).
                        This concept provides a useful construct for the
                        subsequent discussion of the formation of abiotic
                        reductants in anaerobic subsurface systems. Although
                        laboratory studies can be designed to mimic specific
                        redox zones, their occurrence in natural systems is
                        often complex with overlapping and/or completely
                        mixed redox zones.  One result of this scenario is the
                        difficulty in identifying the predominant chemical
                        reductants in these complex systems.
                        These reactive forms are primarily reactive surfaces
                        such as surface complexed Fe(II) and reactive minerals
                        such as green rusts and iron sulfides, all of which form
                        as the result of reactions of high concentrations of
                        ferrous iron and sulfide.  These  abiotic reductants that
                        are known to form as a function of iron and sulfate
                        redox zones are illustrated in Figure 4.1.
Nitrate
Reducing
C HCOj
X
NOj N2
Manganese
Reducing
Corg HC°3
X
MnO; Mn2*
Iron
Reducing
Corg HC°3
>-<^
Fe(OH)3 Fe2*
Sulfate
Reducing
C HC°3
°org
X
SO;' HS"
Methanogenic
Corg HC°3
V_>
CH4
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                                     Abiotic Reductants
                  Surface Complexation               Mineral Formation
            Iron Bearing Hydroxides (Green Rusts):
            GR-CI: [Fe2+Fe3+(OH)8]+ [CI»/?H2O]-
            GR-SO4:[Fe2+Fe3+(OH)12]2[SO4»nH2O]-
            GR-CO3: [Fe2+Fe3+(OH)12]2+ [CO3«nH2O]
                            I
                            O
                            I
                           Fe3+
                    Goethite
Surface
Iron Bearing Oxides:
Magnetite: Fe2+ + 2Fe3+ + 8OH' ^  Fe3O4
                                         Iron Bearing Sulfides:
                                         Mackinawite: Fe2+ + HS-
                                         Pyrite:  FeS  + S°  «-» FeS2
                                          FeS + H+
 Figure 4.1.   Formation of abiotic reductants as a function of iron and sulphate reducing zones.
 4.1 PCEandTCE
 4.1.1 Processes and Pathways
 The abiotic reduction of chlorinated solvents has
 received much attention over the past decade due to
 the observations that:
    • Abiotic reduction pathways result in reaction prod-
      ucts that are of much less concern than those based
      on biologically-mediated reductive transformations
    • The  toxic reaction  products formed from  the
      biologically-mediated  process are susceptible to
      abiotic degradation
    • Lower concentrations  of the targeted chlorinated
      solvents can be achieved in remediation scenarios
      by maximizing geochemical conditions for abiotic
      degradation
 The abiotic reductions of PCE andTCE have been
 demonstrated in a number of abiotic model systems
 and anaerobic microcosms designed to mimic iron-
 reducing and sulfate-reducing zones in anaerobic
 systems. Figure 4.2 illustrates the pathways for both
 the abiotic and  biologically-mediated reduction
                      of PCE and TCE. The abiotic pathway occurs
                      predominantly through reductive elimination
                      resulting in the formation of the reactive intermediate
                      dichloroaceteylene (Lee and Batchelor 2002).
                      Subsequent hydrogenolysis of dichloroacetylene
                      results in the formation of acetylene through the
                      reactive intermediate, chloroacetylene, which is
                      reduced further to ethane and ethene, all of which are
                      relatively innocuous degradation products (Butler and
                      Hayes 2001; Lee and Batchelor 2002). In contrast,
                      the biologically-mediated pathway is dominated by
                      hydrogenolysis (i.e., the replacement of a Cl group
                      with an H) to form TCE. Sequential hydrogenolysis
                      of TCE gives oy-l,2-DCE and subsequently VC, both
                      of which are susceptible to abiotic reduction  resulting
                      in the formation of acetylene, ethene, and ethane.
                      4.1.2 Factors influencing transformation to
                           desired end product
                      The desired end products for the reductive
                      transformation of PCE andTCE are those for
                      which all of the Cl groups have been removed (i.e.,
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                                            Cl
                            Reductive
                            Elimination
                     cu
                       Dichloroacetylene
                        HC
                        Chloroacetylene
                                 A
                             etheylene
                                 Hydrogenolysis
                                                                   H
                                                                       JCE
                                               H3C—CH3
                                                   ethane
 Figure 4.2.  Reaction Scheme illustrating the degradation pathways for PCE in anaerobic systems and the predomi-
             nant processes controlling each of the transformation steps: A = abiotic degradation pathway, B = biotic
             degradation pathway.
  acetylene, ethene, and ethane). Consequently,
  conditions that maximize the potential for abiotic
  reduction, as discussed below, will favor the formation
  of these desired end products. pH is also a factor
  in determining the formation of the desired end
  products as higher values (>8) increase rates of abiotic
  transformations (see Table 4.1) and is thought to
  inhibit the growth of dechlorinating bacteria.
                        4.1.3 Geochemical conditions
                        Our understanding of the geochemical conditions
                        controlling the abiotic reduction of PCE andTCE
                        is the result of laboratory based studies of abiotic
                        model systems and anaerobic microcosms.  In total
                        these studies indicate that subsurface conditions
                        defined as iron and sulfate reducing will promote
                        abiotic reduction of PCE andTCE as a result of
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Table 4.1. Surface area-normalized rate constants, /csa, with units of Lm~2day~1, for PCE, TCE, c/s-DCE and VC mea-
sured in anoxic model studies and anaerobic microcosms.
Exp#
1
2
3
4
5
6
7
8
9
10
12
13
14
15
Reaction System
FeS,
pH 7
FeS,
pH 8
FeS,
pH 9
GR-CI,
pH 8
FeS2,
pH 8
GR-SO4,
pH 8
Fe304,
pH 8
Fe(ll)/goethite,
pH 8
Microcosm,
pH 7
Microcosm,
pH 8
FeS2
Fe304
FeS,
pH=8.3
FeS,
pH=8.3
(0.04 M FeCI2)
PCE
(6.3± 1.6)x10'5
(5.3±0.5)x10'4
(1.21 ±0.1)x10'3
(5.6 ± 1.4)x10'6
(1.6± 1.0) x10'6
NC
NC
NC
(1.8± 1.2)x10'4
(9.1 ± 1.6)x10'4
2.0 x10'5
8.4 x10'7
(7.6 ± 1.0) x10'4
(3.8± 0.3) x 10"3
TCE

(1.6± 0.2) x10'4
(6.4 ± 0.8) x10'4
(2.9±0.61)x1Q-5
(6.4 ± 1.5)x10'5
NC
NC
NC
(6.2± 5.7)x10'4
(1.7± 1.9)x10'3
2.5 x10'5
7.2X10'7
(2.1 ± 0.1) x 10-3
(2.0± 0.1) x10"2
cis-DCE
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
1.3x10-5
5.6 x10'7
NR
NR
VC
NR
NR
NR
NR
NR
NR
NR
NR
NR
NR
2.27x10'5
5.6 x10'7
NR
NR
Reference
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Butler,
Elizabeth
2009
Leite, 2002
Lee, 2002
Jeong, 2007
Jeong, 2007
 the formation of high concentrations of Fe(II) and
 (S-II), and the subsequent formation of reactive
 minerals as illustrated in Figure 4.1. Under most field
 conditions, both abiotic and biologically-mediated
 reduction of PCE and TCE will occur. The relative
 rates of these processes will depend on the abundance
 of dechlorination bacteria and the mass loadings of
 reactive minerals.
4.1.4 Indicator species (chemical)
Indicator species (i.e., indicators of reactivity)
for abiotic reductions are those that will reflect
the reactivity of various abiotic reductants due to
formation and subsequent reactions of ferrous iron
and sulfide.  This can include direct measures of the
reactive species (e.g., mass loadings of iron sulfides)
or measures of species that are not reactive, but
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 may reflect the reactivity of the abiotic reductants
 (e.g., aqueous phase concentration of ferrous iron
 and sulfide).  The direct measure of solid-phase
 reactive species is challenging at best and is based
 primarily on laboratory methods involving sequential
 extraction methods.  These extraction methods
 will provide measures of weakly bound Fe(II) (i.e.,
 surface complexed Fe(II) and strongly bound Fe(II),
 acid-soluble sulfur, and chromium-extractable sulfur
 (CrES), which provide measures of reactive Fe(II) and
 S(-II) bearing minerals (Kostka and Luther III, 1994;
 Heron, Bjerg et al. 1995).
 By comparison, the measurement of aqueous phase
 ferrous iron, sulfide and hydrogen concentrations are
 quite feasible. Additionally, these parameters have
 been measured for the principal aquifers in the U.S.
 and are available in the USGS National Water Quality
 Data Base. Although studies  to determine the efficacy
 of soluble ferrous iron and sulfide as indicators of
 reactivity for  abiotic reductive dehalogenation have
 not yet been reported, aqueous phase concentrations
 of ferrous iron measured in iron-reducing sediments
 were shown to correlated strongly with the rates for the
 abiotic reduction measured for a nitro aromatic probe
 chemical in 21 iron-reducing sediments collected from
 a diverse set of sites across the country.
 When given enough time for reactions to  proceed
 to their maximum extent, reductive capacities are
 defined by the amount of oxidant reduced. For PCE
 reductions by active mineral reactions, reductive
 capacities were found to correlate with the Fe(ll)
 content  (Lee and Batchelor 2003).
 Also, an increase in reduction rate constants for PCE
 and TCE in FeS systems treated with increasing
 concentrations of Fe(II) has been reported, which was
 attributed to  an increase in the presence of different
 types of solid-bound Fe phases with Fe(II).
 4.1.5 Rates of transformation
 Rate constants for abiotic reduction of PCE and
 TCE have been measured in laboratory based abiotic
 model systems and anaerobic microcosms designed
 to mimic iron and sulfate reducing zones in natural
 subsurface conditions. Abiotic degradation rate
 constants for PCE and TCE measured in situ have not
                       been reported.  A summary of pseudo-first-order rate
                       constants generated from these studies are summarized
                       in Table 4.1.  These data are grouped according to
                       the study in which they were generated.  Comparison
                       of rate constants generated from different studies is
                       somewhat problematic primarily due to the differences
                       in procedures used to generate the reactive  minerals
                       resulting in materials with varying reactivity.  Analysis
                       of the rate constants measured within a given study
                       does allow for a number of general observations as
                       reported below.
                       4.1.6 Normalization of rate constants to account
                             for partitioning
                       Rate constants  for the abiotic transformation of PCE
                       and  TCE in Table 4.1 were normalized for  the effects
                       of partitioning  among the gas, aqueous, and solid
                       phases according to:
                                           k     =_j«.
                                            m,corr   j-^
                                                   r
                       where F{, the partitioning factor, is defined as:
                       Kis is calculated as follows:
                                              -K     *
                                              -AM7T~
                       where Ki>d is the solid/water distribution coefficient,
                       and^c is the weight fraction of organic matter in the
                       solid phase. Ki>d can be estimated from the empirical
                       relationship Ki4 = KitOCfoc.

                       These rate constants, which have been adjusted for
                       partitioning, were subsequently normalized to the
                       surface areas of the various reactive mineral phases,
                       providing surface normalized rate constants, £sa>
                       with units of L m~2day~1.  The normalization of rate
                       constants for partitioning and surface area allow for
                       the direct comparison of reduction rates for PCE and
                       TCE measured in the various experimental systems.
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 General observations based on the kinetic data
 reported in Table 4.1:
    • Rates for the abiotic reduction of PCE and TCE
      increase with pH. PCE reduction by FeS increased
      by approximately an order of magnitude with each
      pH unit (Exps.  1, 2 and 3).  Similar results were
      observed for the microcosm studies (Exps. 9 and 10).
    • Based on results of model studies  of individual
      reactive minerals (Exps, 2, 4,  5, 6, 7 and 8), their
      relative reactivities can be assigned as follows:

       FeS > GR-C1 ~ FeS2 > GR-SO4 ~ Fe3O4

      The contribution of any one of these reductants
      to the rate of abiotic reduction will depend on the
      concentration and surface area of the reductant.
    • The pathways for abiotic reduction as illustrated in
      Figure 4.2 follow the same pathway (i.e., reductive
      elimination) regardless of the relative contributions
      of these abiotic reductants,
    • Half lives for biodegradation (-10 days, not shown)
      of PCE andTCE in the anaerobic microcosms were
      shorter than those measured in abiotic systems of
      reactive minerals, 900 to 5,000 days for PCE and
      500-1,000 days for TCE. Tne half lives for abiotic
      reduction were calculated from rate constants that
      were mass normalized to  FeS surface areas (Exps
      9 and 10).
    • Abiotic degradation, though slower than biodegra-
      dation rates, can be significant when biodegradation
      is not complete leading to the formation of cis-DCE
      and VC (Exps 12 and 13).

 Extrapolation of laboratory based generated rate constants
 to field conditions
 Lee and Batchelor have proposed a  method for
 extrapolating first-order rate constants measured in
 model systems of reactive iron sulfides to aquifers
 containing the reactive iron sulfide  (Lee and Batchelor
 2002).  The following example is based on the
 reduction kinetics measured for TCE in a  suspension
 of GR-SO4.  A number of assumptions are required
 for this extrapolation:
    • The initial reductive capacity concentration (C°RC)
      in the aquifer can be  calculated by assuming that
      green rusts  represents 1% of the iron content  of
     the soil
   • Based on the assumption that iron content is 2.6%,
     a bulk density 1.4 kg/L, and a porosity of 0.40, the
     mass of iron  per volume water can be calculated
     as 91 g/L
   • Assuming that GR-SO4 is 52.6%  iron, the green
     rust concentration can be calculated as 1.73 g/L
   • Based on measured rate constants in the GR-SO4
     model systems, the calculated value for C°RC is
     0.0225 mM
   • Assuming a soil organic fraction of 0.005  and an
     organic carbon partition coefficient of 206 L/kg,
     a partition coefficient of 4.66 can be calculated
     for TCE
Based on these assumptions, the following equation
was then used to calculate a pseudo-first-order rate
constant of 0.0037 day-1, which gives an apparent
half-life of 190 days in the simulated aquifer for the
reduction of TCE by GR-SO4:
               *! =
                    (k IPCE (CRC j
                     l/K+C
                              RC
Where k is the experimentally determined pseudo-first-
order rate constant measured in the GR-SO4 model
system, PCE  is the partition coefficient for partitioning
to the gas, aqueous and solid phases, Kis the sorption
coefficient, and C°RC is the initial reductive capacity
concentration.
This same approach was used to extrapolate results
from laboratory studies of PCE in suspensions of
pyrite and magnetite to estimate half lives for PCE of
13 days by pyrite and 608 days by magnetite under
field conditions (Lee and Batchelor 2003). These
results  suggest that pyrite formed under sulfate
reducing conditions has the potential to  significantly
contribute to the abiotic reduction of PCE.
4.2 TCA
4.2.1 Processes and Pathways
Relative to PCE andTCE, studies of the abiotic
degradation of TCA are limited. Figure 4.3 illustrates
the pathways for both  the abiotic hydrolysis and
reduction, and biologically-mediated reduction of
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
                          Ground Water Issue  33

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 TCA based on our knowledge of the existing process
 science (Vogel and McCarty 1987; Haag and Mill
 1988; Butler and Hayes 2000; Gander, Parkin et al.
 2002). In the case of TCA, base-catalyzed hydrolysis
 results in the formation of 1,1-DCE through
 elimination and acetic acid through nucleophilic
 substitution(Haag and Mill 1988). Hydrogenolysis
 mediated by both abiotic and biologically mediated
 processes results in the formation of 1,1-DCA, and
 subsequently CA, which is susceptible to hydrolysis to
 form ethanol. Laboratory studies have demonstrated
 that the formation of acetic acid occurs at a rate
 - 5 times faster than the formation of 1,1 -DCE
 (Haag, Mill et al. 1986). Although product recoveries
 are typically quite low  (< 10%) for the formation
 of 1,1-DCA in FeS suspensions, 1,1-DCA was the
 only product observed (Butler and Hayes 2000;
 Gander, Parkin et al. 2002). With the addition of
 a methanogenic consortium to the FeS suspensions,
                                 product recovery of 1,1-DCA increased to -46%
                                 (Gander, Parkin et al. 2002).
                                 4.2.2 Factors influencing transformation to
                                      desired end product
                                 Of the three transformation pathways for TCA
                                 illustrated in Figure 4.3, it is abiotic hydrolysis that
                                 results in formation of the degradation product (i.e.,
                                 acetic acid) of least concern.  Because the hydrolysis
                                 of TCA is base catalyzed, increases in pH will increase
                                 the rate of TCA hydrolysis; however  the rate of
                                 elimination, which leads to the formation of 1,1-TCE,
                                 will also increase with pH.
                                 4.2.3. Geochemical conditions
                                 The abiotic reduction of TCA in mackinawite (FeS)
                                 suspensions suggest that sulfate-reducing conditions
                                 will favor the abiotic reduction of TCA (Butler and
                                 Hayes 2000; Gander, Parkin et al. 2002).
                                 4.2.4 Rates of transformation
Reductive
Elimination
                 Cl
                           og
                             F
                            *
Hydropenolysis
       A, B
                                                           Hydrolysis
                                                                    0
                      1,1-DCE
                  H
                                                                         -CH3
                                                                Acetic Acid
                                             1,1-DCA
                                                          Hydrolysis
                                                 CA
                                                          Ethanol
  Figure 4.3.  Reaction scheme illustrating the degradation pathways for TCA in anaerobic systems and the predomi-
             nant processes controlling each of the transformation steps: A = abiotic degradation pathway, B = biotic
             degradation pathway.
34   Ground Water Issut
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 Based on the limited process science available, the
 abiotic reduction of TCA is controlled primarily by
 the presence of FeS in aquifer systems. The overall rate
 term is characterized by a second-order rate term:

 where {FeS} is the surface area concentration given by
 the product of the mass concentration (S, g L"1). The
 second-order rate constant, £FeS (L m"2d"1) is defined
 as:
 The £FeS determined by Gander, et. al. (Gander, Parkin
 et al. 2002) of 0.26 L m"2 d"1, compares quite well to
 the rate constant of 0.47 L m"2 d"1 reported by Butler
 and Hayes (Butler and Hayes 2000).
 4.3 Dioxane
 1,4-Dioxane (1,4-Diethyleneoxide), often called
 dioxane because the 1,2 and 1,3 isomers of dioxane
 are rare, is a heterocyclic organic compound. It is a
 colorless liquid with a faint sweet odor similar to that
 of diethyl ether.  It is classified as an ether and is used
 as a solvent for fats, greases, and resins and in various
 products including paints, lacquers, glues, cosmetics,
 and fumigants. As a miscible compound, 1,4-Dioxane
 is conservatively transported with no significant known
 abiotic degradation pathway.
5. SUMMARY OF BIOTIC AND ABIOTIC
   TRANSFORMATIONS
Chlorinated solvents are altered by intrinsic biotic
and abiotic processes. Transformations may be as such
that endpoints fall short of complete degradation to
innocuous compounds. The determination of which
endpoints are reached, the processes of transformation,
and the needed site data are critical for assessing and
modeling transport, and deciding on Monitored
Natural Attenuation (MNA) as a remedy. MNA is a
component of 22% of all Record of Decision (ROD)
in Superfund sites. Therefore, relevancy of MNA
research to OSWER and others in terms of reducing
uncertainty over field processes and better remedial
decision-making are the expected  impacts of this work.
Many sites with chlorinated solvent contamination
may never proceed to a contaminant fate and transport
modeling stage, and therefore use  the data to make
statistical inferences. For those sites, a thorough
recognition of transformation processes to form a
strong foundation for the development of a conceptual
site model and integrating site data to conceptualize
fate and transport processes without the  benefit of
a computational model are essential. A quantitative
conceptual model, based upon transformation
knowledge and field observation provides the
framework for understanding and remediating a
site. The conceptual model also provides the basis
for developing and applying numerical models. This
document will briefly describe the process of applying
models (Section 6), given the uncertainty in processes
and input parameters.  It will continue by discussing
alternative model formulations and their potential
utility. Transformation endpoints are summarized
below to facilitate in classification of observed plume
behaviors and patterns:
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                         Ground Water Issue  35

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   Complete reductive dechlorination
PCE -» TCE -+ DCE
                              ethene, ethane
   Incomplete/limited reductive dechlorination
   PCE -> TCE -> DCE
   or
   PCE -» TCE -» DCE -* VC
PCE, 7~CE, DCE,  VC plumes observed and all decreasing in
concentration, mass, and/or extent.
Ethane and ethene detected.
Strong reducing conditions (oxygen, nitrate, sulfate are depleted
relative to background wells)
Sufficient electron donor is present.
Requisite microbial community is present.
Presumed mechanism is reductive dechlorination.
                                                       PCE, TCE, DCE plumes or PCE, TCE, DCE, VC plumes
                                                       observed.
                                                       DCE and/or VC persist.
                                                       Weak reducing conditions (sulfate reduction and/or
                                                       methanogenesis is not occurring) and/or requisite microbial
                                                       community is not present.
                                                       Presumed mechanism is reductive dechlorination, but stopped
                                                       by lack of appropriate enzymes
   Biotic/abiotic transformations
   PCE -> TCE
                                                       PCE and TCE plumes observed and both decreasing in
                                                       concentration along the flow path.
                                                       No observed DCE or VC plumes observed.
                                                       Acetylene observed in ground water.
                                                       Strong reducing conditions (oxygen, nitrate, sulfate are depleted
                                                       relative to background wells)
                                                       Sufficient electron donor is present.
                                                       Requisite microbial community is present.
                                                       Mineralogical analysis would indicate presence of reactive
                                                       minerals
                                                       Presumed mechanisms are reductive dechlorination of PCE to
                                                       TCE, and abiotic transformation of PCE and TCE.
   Degradation of TCA
          1,1-DCE^CA
                                                       TCA, 1,1-DCA, and CA plumes are observed
                                                       Presumed mechanisms are reductive dechlorination of TCA to
                                                       DCA and abiotic transformation of PCE and TCE
                                                       No known culture has been found that is capable of complete
                                                       dechlorination of TCA to ethane.
   Degradation of 1,4-dioxane
                                                       Presumed mechanism is aerobic respiration, as both growth-
                                                       supporting and non-growth supporting (i.e., cometabolism).
                                                       No evidence available to suggest abiotic transformation.
                  Monooxygenase reactions
                 :^M^^»»:
              cytochrome p450

                   CO2
                                        CO,
36  Ground Wah
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 6. MODELING APPLICATIONS AND
    CONCEPTUALIZATIONS FOR CHLORINATED
    SOLVENT TRANSFORMATIONS
 6.1 Historical Background
 The scientific and conceptual basis for models of
 ground-water flow and contaminant transport
 date to the latter part of the 19™ century.  Darcy's
 experiment on  flow through porous media had the
 purpose of designing filters for the City of Dijon's
 water supply (Darcy, 1856). It is important to note
 that the experiment was performed on a sand filter,
 where Darcy selected and prepared a relatively uniform
 sand and placed it in an artificial environment: the
 filter.  Later the concept of how water flowed through
 uniform materials was extrapolated to the natural
 environment (Slichter, 1899), where an important
 distinction holds:  the materials are neither uniform
 nor deliberately placed (for the most part).  Methods
 to quantify flow to wells (Thiem, 1932; Theis, 1935)
 used mass conservation along with Darcy's Law
 were developed in the early 20™ century. Although
 simplified, these methods were successful for
 determining flow to  wells, largely because the location
 of materials of differing conductivity is less important
 for determining flow of water, than it is for transport
 of contaminants, although this factor was not realized
 at the time.
 Mass conservation is also the main principle
 underlying the transport of contaminants in aquifers.
 Here the development of the transport  theory in the
 1950s (Bear, 1972) followed the development of
 the theory of heat conduction in uniform materials
 (Carslaw and Jaeger, 1959). In addition to the similar
 basis in mass conservation, the original development
 was for uniform materials.  This limitation is
 understandable because the numerical methods and,
 more importantly, the computer power to solve
 problems with heterogeneities did not exist at the time.
 6.2 Types of Models
 In the most commonly used approaches, the solutions
 for ground-water flow and contaminant transport
 are found separately. Thus  the distinction is made
 between ground-water flow models and contaminant
 transport models.  Although in this introduction both
are discussed, contaminant transport is the major focus
of this issue paper.
Two broad mathematical approaches have been
developed to solve the mass conservation equations
for ground-water flow and contaminant transport.
The first is the historic method of solving the partial
differential equation(s) for mass conservation.  These
are exact solutions of the equations found through the
methods of calculus1. The solutions apply everywhere
throughout the domain, but require restrictive
assumptions.  For contaminant transport, ground-
water flow must be steady (not varying with time) and
uniform (not varying with position).  It is represented
as a simple constant in the analytic solution for
contaminant transport. Consequently heterogeneity
cannot be included, neither converging flow toward
wells nor irregular hydrologic boundaries such as
streams and rivers2.
The alternative is numerical solution which
approximates the solution over a set of points (usually
a grid), using approximate solution techniques for
the same partial differential  equations.  Numerical
methods are much more flexible than analytic
solutions because fewer major constraints are imposed.
This does not mean that the numerical methods are
not without limitations, but some of the basic and
severe constraints imposed on analytic solutions have
been overcome.
In the 1970s the first numerical models were
developed and made publically-available.
Concurrently there has been a parallel effort to develop
analytical models. Most developers justify the use of
these models as tools to test numerical models, a use to
which they are well suited, or as a screening tool. The
apparent idea behind screening tools is that because
they are simplified, they could be used to perform
quick analyses of transport when  a full-blown analysis
is not warranted or possible. Caution is needed in the
1    Hybrid types have been developed that blur the distinction between
    the two major types. Most familiar are the analytic element methods
    which solve the ground-water flow equation analytically over a series
    of domains, which are then linked to each other through what is
    essentially a numerical approach.
2    Analytic element methods do have the ability to include irregular
    boundaries, flow to wells and to a less common degree, heterogeneity.
    Inclusion of these features would have been part of the motivation for
    development of the method.
Synthesis Report on State of Understanding of Chlorinated Solvent Transformatio
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  use of simplified or screening models, and for example,
  several questions need to be answered:
       Are the assumptions in the simplified models met
       by the field sites being screened?
       Has it been demonstrated that simplified models
       are appropriate for screening?
       Have sufficient data been collected to support use
       of the model? (i.e., to avoid a "garbage in/garbage
       out" situation, have the sites been characterized)
       Has the site-specific model (i.e., computer code plus
       its site data)  been shown to represent the specific
       field site? If not, has an uncertainty analysis been
       performed?
  6.3 Parameter  Measurement in the Field
  Field methods exist to measure some model parameters
  in the field, other parameters must be estimated. For
  example, hydraulic conductivity can be measured by
  aquifer pumping tests or slug tests. Aquifer pumping
  tests might be impacted by rain or early termination
  of pumping. Slug test results might be affected by
  skin effects and the tests are acknowledged to provide
  results close to the  location of the tested well. In
  contrast aquifer pumping test results can cover a wider
  extent of the aquifer. Neither of these methods is
  free from inaccuracies, nor do they typically produce
  data that are as spatially refined as needed for detailed
  simulation.
  Other parameters are not directly measured. Porosity
  is usually taken from literature values on aquifer type
  and not determined on a site-specific  basis. As will
  be seen below, an approach to chlorinated solvent
  modeling relies on first-order rate constants. These
  are not directly measured but are estimated from
  concentrations in wells across a site measured at
  various times.
  6.4 Model Application
  Typical model applications use a combination of
  measured, estimated and literature parameters as a
  starting point. Even with the most comprehensive
  investigation, numerical models could use more data
  on parameter spatial variability than is available.
  Because of limitations in the values for the initial
  parameter values, parameters can be legitimately
  changed to create a model that represents the field
                       data on contaminant concentrations.  This process is
                       called calibration and is necessary to demonstrate that
                       the model reproduces conditions observed in the field.
                       Because it is essentially a process of interpolation, it
                       does not guarantee that the model will predict future
                       behavior, nor that the chosen parameters uniquely
                       determine the model results. Recent research on
                       calibration shows, in fact, that there is a limit beyond
                       which calibration cannot further refine parameters
                       towards reaching an ideal unique or "correct"
                       parameter set. This limitation derives from limitations
                       in the array of science that supports development and
                       application of models from the historic development
                       of the conceptual basis  of the models, through field
                       measurement and application of computer codes.
                       6.4.1 Model  Uses
                       What then are the best uses of models?  There is
                       a near consensus that models are the best tool for
                       integrating the various  processes occurring at field
                       sites.  A consequence of applying the model can
                       be the understanding of which processes govern
                       transformation at a site. Questions can be asked
                       as:  "Does abiotic transformation alone explains the
                       reduction in contaminant mass at this site?"
                       Recent writing on model application highlights the
                       limitations of presuming certainty from application
                       of environmental models in general. Oreskes (2003)
                       highlights the characteristics of problems where
                       application of environmental models is likely to be
                       highly successful. Two  of her examples are planetary
                       motion, where predicted locations of planets can be
                       tested by nightly telescope observation, and weather
                       forecasting where the ability to forecast future weather
                       is known by all to be limited, but the  forecasts are
                       valuable none-the-less.  In a white paper published
                       by Ground Water, Konikow (2011) suggested that the
                       objectives for modeling be redefined.
                       Beyond understanding site behavior, models are
                       useful for situations where we plan to  make future
                       measurements.  Some  examples are:
                           • More generally, design of remedial systems where
                            performance data will be collected to track the
                            progress of the remedy
                           • As a specific example: Prediction of the course of
38   Ground Water Issu
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      monitored natural attenuation (MNA) remedies,
      where by definition monitoring will continue to
      document the efficacy of remediation
 6.4.2 Contaminant transport models
 Fate and transport models are classified into  two
 categories:
 A.  Model with a sequential first-order decay
    process
    • Solute fate and transport model
    • Sorption and retardation
    • NAPL/water partitioning
    • Groundwater flow velocity
    • Biodegradation rate-constant
 In the anaerobic reductive dehalogenation of
 chloroethenes, chloroethenes were utilized as
 respiratory electron acceptors. Bacteria can reductively
 dechlorinate perchloroethene (PCE) to trichloroethene
 (TCE), r»-dichlorothene (rw-DCE), vinyl chloride
 (VC), and finally ethane (ETH). The ultimate
 electron donor used in the process is H2 generated
 from the fermentation substrates, often mediated by
 mixed culture.
 The sequential dechlorination is described in the
 following pathway:

       PCE -» TCE -» oj-DCE -» VC -» ETH

 Each of the five solute (PCE and its daughter
 products) simultaneous transport and degradation is
 described by one-dimensional advection-dispersion
 equation with first-order degradation kinetics.  It
 is assumed that the yield coefficients are based on
 stoichiometric relations.
             = L),
  R
           TCE
    TCE
dt
                         dx
              -v.
                                     ac
                       TCE
                     dx
Y       k   r    —
^TCE/PCE^PCE^PCE
                                           r
                                           ^
                                            dt
               = D
                        dx2
                                                                 -v
                                                                      dC
                                                                         DCE
                  V
                  1
                   DCE 'I TCE ^TCE
                                                                      —k   C
                                                                   TCE   ^DCE ^
                                                             VC
                                                                 -V,
                v
                J
                                                           I-    r
                                                           ^    ^
                                                    VC/DCE ^DCE ^ DCE
                                                                               dx
                                                                                 • v-T/r'^T/r
                                                                            ETH
                                             dt
                                        dx
                                                     Y      IT  r   —if    r
                                                     -I. T7TTT If//"1 *vr/f ^—^ T/f    *»/ ~C"~T~LJ ^—^
                                                      rLlrt/yL^  KC  KC     rLlrt
                                           'ETH
                                   concentrations (mg/L)
                                   ^PCE> ^TCE> ^DCE> ^vc> ^ETH  " first-order degradation
                                   rates (day"1)

                                   YTCE/PCE> YDCE/TCE> YVC/DCE> YETHWC ~~ yield
                                   coefficients (mg/mg)

                                   Kinetic constants for the sequential degradation of
                                   PCE

                                    constant    value (day"1)
kpcE
^TCE
I
-------
 The model simulates the microbial transformation of
 the seven solutes (PCE, TCE, DCE, VC, ETH, H2
 and CH4), the growth and decay of three microbial
 populations: PCE/TCE dechlorinators (dechl), DCE/
 VC dechlorinators (dech2), and hydrogenotrophic
 methanogens (meth) (or maybe homoacetogens). A
 one-dimensional transport model is described with
 dispersion, advection, and rate-limited sorption and
 desorption, reductive dechlorination kinetics with
 competitive inhibition and microbial growth and
 decay.
      oL,
         TCE
                  a
                            *
                             C
                              res
f'         1 I
-^s,TCE,dechl  L """
                             K
                               s,PCE,dechl
             X
                      r  -r
                      ^    ^
, dechl

                             H2   ^ H2,th,dech)
                                              L decftl

                                              \
                                        + c
                                                         r,
                                       3^       x>!   3x2      *  3x
                                             /
                                                                     ^DCE,dech2^dech
                                                           C.
                                                            DCE
                                              K
                                                                            +c
                                                                          DCE
                                            x
                                                     C   -C
                                                     ^     ^
                                                ^s,H2,dech2
                                                        + (€„ -C
                                                                 _
                                                                 ~
9x 9jt
Cvc
V 1 | ^DCE
^S,VC,dech2\ L ' ^
V J^s,DCE,dech2 )
ch2-^ decK
\
/
                                                                            r   -
                                                                            ^
                                                                   X
                                                                —C      \
                                                                  ^H2,th,dech )
                                 Beyond understanding site behavior, models are
                                 useful for situations where we plan to make future
                                 measurements. This Issue Paper will form the basis
                                 for simulating chlorinated solvent transformation
                                 along streamlines using biotic or abiotic processes as
                                 appropriate.
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