July 12, 1999
EPA-SAB-CASAC-CON-99-006
Honorable Carol M. Browner
Administrator
U. S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20460
Subject: Notification of a Consultation on the Estimation of Carbon
Monoxide Exposures and Associated Carboxyhemoglobin Levels
in Denver Residents usingpNEM/CO (Ver. 2.0)
Dear Ms. Browner:
The Clean Air Scientific Advisory Committee (CASAC) of the Science Advisory Board
(SAB), met on June 9-10, 1999 to review and/or consult on several issues. During the meeting,
the Committee conducted a Consultation with staff from the Office of Air and Radiation (OAR)
on OAR's draft Estimation of Carbon Monoxide Exposures and Associated Carboxyhemoglobin
Levels in Denver Residents using pNEM/CO (Ver. 2.0). This document was discussed as part of
the continuing peer review by CASAC of the National Ambient Air Quality Standards (NAAQS)
for Carbon Monoxide.
The SAB has developed the Consultation as a mechanism to advise the Agency on
technical issues that should be considered in the development of regulations, guidelines, or
technical guidance before the Agency has taken a position. A Consultation is conducted under
the normal requirements of the Federal Advisory Committee Act, which include advance notice
of the public meeting in the Federal Register.
As is our customary practice, there will be no formal report from the SAB as a result of
this consultation, nor do we expect any formal response from the Agency. However, the
Committee looks forward to continuing its peer review of the scientific basis of the Carbon
Monoxide NAAQS.
Sincerely,
Dr. Joe Mauderly, Chair
Clean Air Scientific Advisory Committee
Science Advisory Board
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U.S. Environmental Protection Agency
Science Advisory Board
Clean Air Scientific Advisory Committee (CASAC)
Chair
Dr. Joe Mauderly, Director of External Affairs, Senior Scientist, Director of National Environmental
Respiratory Center, Lovelace Respiratory Research Institute, Albuquerque, NM
Members
Mr. John Elston, Administrator, Office of Air Quality Management, State of New Jersey, Department of
Environmental Protection and Energy, Trenton, NJ
Dr. Philip K. Hopke, Dean of the Graduate School, and R.A. Plane Professor of Chemistry, Clarkson
University, Potsdam, NY
Dr. Eva J. Pell,, Steimer Professor of Agricultural Sciences, Pennsylvania State University, University
Park, PA
Dr. Arthur C. Upton, M.D., Director, Independent Peer Review, CRESP, Environmental and
Occupational Health Sciences Institute, Piscataway, NJ
Dr. Sverre Vedal, M.D., Professor of Medicine, University of British Columbia, Vancouver, BC, Canada
Dr. Warren White, Senior Research Associate, Washington University, Chemistry Department, St.
Louis, MO
Consultants
Dr. Stephen M. Ayres, M.D., Director, International Health Programs, Virginia Commonwealth
University/Medical College of Virginia, Richmond, VA
Dr. Thomas E. Dahms, Professor and Director, Anesthesiology Research, Department of
Anesthesiology, St. Louis University School of Medicine,St. Louis, MO
Dr. Victor G. Laties, Professor Emeritus, Department of Environmental Medicine, University of
Rochester Medical Center, Rochester, NY
Dr. Brian Leaderer, Professor, Division of Environmental Health Sciences, Yale University School of
Medicine, New Haven, CT
Dr. Lawrence D. Longo, M.D., Professor, School of Medicine, Department of Physiology, Center for
Perinatal Biology, Departments of Physiology and Gynecology and Obstetrics, School of
Medicine, Loma Linda University, Loma Linda, CA (did not attend meeting)
Science Advisory Board Staff
Mr. Robert Flaak, Designated Federal Official (DFO) and Team Leader, Committee Operations Staff,
US Environmental Protection Agency, Science Advisory Board, Washington, DC
Ms. Diana Pozun, Management Assistant, US Environmental Protection Agency, Science Advisory
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Board, Washington, DC
NOTICE
This report has been written as a part of the activities of the Science Advisory Board, a
public advisory group providing extramural scientific information and advice to the
Administrator and other officials of the Environmental Protection Agency. The Board is
structured to provide balanced expert assessment of scientific matters related to problems faced
by the Agency. This report has not been reviewed for approval by the Agency; and hence, the
contents of this report do not necessarily represent the views and policies of the Environmental
Protection Agency or other agencies in the Federal government. Mention of trade names or
commercial products does not constitute a recommendation for use.
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