^|         UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                       WASHINGTON, D.C. 20400
                                        EPA-SAB-CON-91-005
                                                         OFFICE OF

                                                      THE ADMINISTRATOR
September 30,  1991

The Honorable William Reilly
Administrator
U.S. Environmental Protection Agency
401 M street, s.w,
Washington, D.C.  20460

Dear Mr. Reilly:

     On July 24, 1991 the Executive Committee of the Science
Advisory Board  (SAB) conducted a consultation on updating EPA's
"Cancer Risk Assessment Guidelines".  3?he SAB has developed
consultation as mechanism to advise the Agency on technical
issues that should be considered in the development of
regulations, guidelines, or technical guidance before the Agency
has taken a position.  A consultation is conducted under the
normal FACA requirements, which include advance notice of the
public meeting in the Federal Register.

     The Committee met with staff from ORD's office of Health and
Environmental Assessment to discuss a series of questions related
to hazard identification, dose-response assessment, exposure
assessment, and rislc characterization of carcinogens.

     The Committee believes that the consultation achieved its
goal by discussing several views and priorities that EPA could
consider in developing its update of these important Guidelines.
As is our customary practice there will be no formal report from
the SAB as result of this consultation, nor do we expect any
formal response from the Agency.

     We look forward to advising the Agency in the future by
consultations as well as through more formal scientific reviews.


                                   Sincerely,
                                                      Chair
                                   Executive Committee
                                   Science Advisory Board

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