r t t united states Contaminant Environmental Protection Agency Information Sheets (CISs) for the Draft Fourth Preliminary Contaminant Candidate List (PCCL 4) Nominated Contaminants ------- Office of Water (4607M) EPA 815-R-15-003 January 2015 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants Contents 1.0 Introduction 1 2.0 Summary of the Chemicals Classification Process from the PCCL to CCL 3 3.0 CCL 4 Chemicals CISs Explanation 5 4.0 Summary of the Microbes Classification Process from the PCCL to CCL and CISs Explanation 9 5.0 References 10 Appendix 1. Chemical Contaminant Information Sheets Al-1 Appendix 2. Microbial Contaminant Information Sheets A2-1 Page i of iv ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants Page ii of iv ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the Draft PCCL 4 Nominated Contaminants EPA 815-R-15-003 CASRN CCL CCL 3 CCL 4 CIS DWEL EEC EPA HA FR HRL IARC IRIS L L? Ibs LOAEL MCL MCLG MMWR NL NL? NOAEL NTP OEHHA OPP PCCL PCCL 4 PWS RfD SRS SDWA WBDO WHO Abbreviations and Acronyms Chemical Abstract Services Registry Number Contaminant Candidate List EPA's Third Contaminant Candidate List EPA' s Fourth Contaminant Candidate List Contaminant Information Sheet Drinking Water Equivalent Level Estimated Environmental Concentration United States Environmental Protection Agency Health Advisory Federal Register Health Reference Level International Agency for Research on Cancer Integrated Risk Information System List List? Lethal dose 50; an estimate of a single dose that is expected to cause the death of 50 percent of the exposed animals; it is derived from experimental data. Pounds Lowest Observed Adverse Effect Level Maximum Contaminant Level Maximum Contaminant Level Goal Morbidity and Mortality Weekly Report Not List Not List? No Observed Adverse Effect Level National Toxicology Program Office of Environmental Health Hazard Assessment (California) Office of Pesticide Programs Preliminary-CCL EPA' s Fourth Preliminary-CCL Public Water System Reference Dose Substance Registry System/Substance Registry Services Safe Drinking Water Act Waterborne Disease Outbreak World Health Organization Page ill of iv ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants Page iv of iv ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants 1.0 Introduction Section 1412(b)(l) of the Safe Drinking Water Act (SOWA), as amended in 1996, requires EPA to publish the Contaminant Candidate List (CCL) every five years. The SDWA specifies that the list must include contaminants that are not subject to any proposed or promulgated National Primary Drinking Water Regulations (NPDWRs), are known or anticipated to occur in public water systems (PWSs) and may require regulation under the SDWA. EPA uses this list of unregulated contaminants to help the agency identify priority contaminants for regulatory decision making and to prioritize research and data collection efforts. SDWA also requires the agency to consult with the scientific community, including the Science Advisory Board, and provide notice and opportunity for public comment prior to the publication of the Final CCL. In addition, SDWA directs the agency to consider the health effects and occurrence information for unregulated contaminants to identify those contaminants that present the greatest public health concern related to exposure from drinking water. EPA published the third CCL (CCL 3), which listed 116 contaminants on October 8, 2009 (74 FR 51850 (USEPA, 2009a)). In developing the CCL 3, EPA implemented a multi-step process to select contaminants for the final CCL 3, which included the following key steps: (1) The identification of a broad universe of potential drinking water contaminants (CCL 3 Universe); (2) Screening the CCL 3 Universe to a Preliminary CCL (PCCL) using screening criteria based on the potential to occur in PWSs and the potential for public health concern; (3) Evaluation of the PCCL contaminants based on a more detailed review of the occurrence and health effects data using a scoring and classification system to identify a final list of 116 CCL 3 contaminants; and (4) Incorporating public input and expert review in the CCL 3 process. Steps 1, 2 and 3 in the process are described in detail in the CCL 3 support documents: • Final CCL 3 Chemicals: Identifying the Universe (USEPA, 2009b); • Final CCL 3 Chemicals: Screening to a PCCL (USEPA, 2009c); • Final Contaminant Candidate List 3 Chemicals: Classification of the PCCL to the CCL (USEPA, 2009d); • Final CCL 3 Microbes: Identifying the Universe (USEPA, 2009e); • Final CCL 3 Microbes: Screening to the PCCL (USEPA, 2009f); and • Final CCL 3 Microbes: PCCL to CCL Process (USEPA, 2009g). These documents can be found on the EPA web site at: http://www2.epa.gov/ccl/contaminant- candidate-list-3-ccl-3 or at http://www.regulations.gov (docket ID: EPA-HQ-OW-2007-1189). After a Final CCL is published, SDWA section 1412(b)(l)(B)(ii) as amended in 1996, requires EPA at five year intervals to make determinations of whether to regulate or not to regulate no fewer than five contaminants from the CCL in a process called regulatory determinations. This is Page 1 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants a separate process from the listing of contaminants on the CCL. The 1996 SDWA Amendments specify three criteria to determine whether a contaminant may require regulation: • the contaminant may have an adverse effect on the health of persons; • the contaminant is known to occur or there is a substantial likelihood that the contaminant will occur in PWSs with a frequency and at levels of public health concern; and • in the sole judgment of the Administrator, regulation of such contaminant presents a meaningful opportunity for health risk reduction for persons served by PWSs. If EPA determines that these three statutory criteria are met and makes a final determination to regulate a contaminant, the agency has 24 months to publish a proposed Maximum Contaminant Level Goal1 (MCLG) and NPDWR2. After the proposal, the agency has 18 months to publish and promulgate a final MCLG and NPDWR (SDWA section 1412(b)(l)(E))3. On February 11, 2011, as a separate action, the agency issued a positive regulatory determination for perchlorate, a chemical listed in CCL 1, CCL 2 and CCL 3 (76 FR 7762 (USEPA, 2011)). Recently, EPA has published preliminary regulatory determinations for five unregulated contaminants on the CCL 3 (79 FR 62716 (USEPA, 2014a)). The five contaminants include: dimethoate; 1,3-dinitrobenzene; strontium; terbufos and terbufos sulfone. The agency is making preliminary determinations to regulate one contaminant (strontium) and to not regulate four contaminants (dimethoate; 1,3-dinitrobenzene; terbufos; and terbufos sulfone). Therefore, the agency is removing perchlorate and these five contaminants from the Draft Fourth CCL (CCL 4), pending the result of the final regulatory determinations for CCL 3. EPA conducted an abbreviated evaluation and selection process for the CCL 4. This abbreviated CCL 4 process includes a three pronged approach: (1) carrying forward CCL 3 contaminants (minus those with regulatory determinations), (2) seeking and evaluating nominations from the public for additional contaminants to consider and (3) evaluating any new data for those contaminants with previous negative regulatory determinations from CCL 1 or CCL 2 for potential inclusion on the CCL 4. As part of the process to develop the CCL 4, EPA published a Federal Register notice (77 FR 27057 (USEPA, 2012)) requesting that the public submit nominations for chemical and microbial contaminants to be considered for inclusion on the CCL 4. EPA also requested supporting information that has been made available since the development of the CCL 3 or existing information that was not considered in the development of the CCL 3, which shows that the nominated contaminant may have an adverse health effect on people and occurs or is likely to 1 The MCLG is the "maximum level of a contaminant in drinking water at which no known or anticipated adverse effect on the health of persons would occur, and which allows an adequate margin of safety. Maximum contaminant level goals are non-enforceable health goals." (40 C.F.R. 141.2; 42 U.S.C. 300g-l) 2 An NPDWR is a legally enforceable standard that applies to public water systems. An NPDWR sets a legal limit (called a maximum contaminant level or MCL) or specifies a certain treatment technique (TT) for public water systems for a specific contaminant or group of contaminants. The MCL is the highest level of a contaminant that is allowed in drinking water and is set as close to the MCLG as feasible using the best available treatment technology and analytical methods and taking cost into consideration. 3 The statute authorizes a nine month extension of this promulgation date. Page 2 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants occur in public water systems. EPA reviewed the nominations and supporting information provided by nominators to determine if any new data were provided that had not been previously evaluated for CCL 3. The agency also collected additional data for the nominated contaminants, when it was available, from both CCL 3 data sources that had been updated and from new data sources that were not available at the time of CCL 3. A complete list of references provided by nominators can be found in the support document Summary of Nominations for the Fourth CCL (USEPA, 2015a). A more detailed description of the CCL data sources collected by EPA may be found in the support document Data Sources for the CCL 4 (USEPA, 2015b). EPA evaluated the nominated contaminants utilizing the best available health effects and occurrence data and the same process for screening and scoring contaminants that was used for CCL 3. A summary of the process and data used to screen the contaminants nominated for CCL 4 from the CCL 4 Universe to the PCCL 4 is included in the Screening Document for the Draft PCCL 4 Nominated Contaminants (USEPA, 2015c). This document summarizes the process used to select contaminants from the PCCL for the CCL. This document also presents the Contaminant Information Sheets (CISs) for the nominated contaminants qualified for inclusion on the PCCL 4. The purpose of the CISs is to summarize the data used to evaluate the nominated contaminants and to select contaminants for the Draft CCL 4. For CCL 3, EPA published CISs for the 561 chemicals (USEPA, 2009h) and the 29 microbial contaminants (USEPA, 2009g) on the PCCL 3 (these documents include the CISs for the 116 contaminants on the Final CCL 3 as well). In addition, Appendix E of the Protocol for the Regulatory Determinations 3 Including Appendices A-F (USEPA, 2014b) includes a summary of updated health and occurrence data used to evaluate 35 CCL 3 contaminants in the regulatory determinations process. This document presents 20 chemical CISs for the nominated chemicals listed on the PCCL 4 (including CISs for the seven nominated chemicals that made the Draft CCL 4) and four microbial CISs for the nominated microbes that are listed on the PCCL 4 (including CISs for the two nominated microbes that made the Draft CCL 4). 2.0 Summary of the Chemicals Classification Process from the PCCL to CCL This section briefly summarizes the process developed under CCL 3 to evaluate contaminants from the PCCL to assess if they should move forward to the CCL. EPA used this same process to evaluate the nominated contaminants for listing on the Draft CCL 4. A detailed explanation of this step in the process is provided in the Final Contaminant Candidate List 3 Chemicals: Classification of the PCCL to CCL (USEPA, 2009d) and its appendices. To identify chemicals from the PCCL to include on the CCL, EPA used classification models and a scoring system as tools. The classification models were used to process complex data in a consistent and reproducible manner. An overarching premise in using classification models to prioritize contaminants is that different contaminants can be compared on the basis of similar attributes. The attributes are properties used to categorize contaminants for their potential to occur in drinking water and for their potential to cause adverse health effects. Four attributes were selected including two attributes describing health effects (Potency and Severity) and two Page 3 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants attributes describing occurrence (Prevalence and Magnitude); these are discussed in more detail in Section 3.0 of this document. Scoring protocols were developed for each of the four attributes and these scores were used as input for the classification models. The scores for each attribute increase with increasing potential to cause adverse health effects or potential to occur in drinking water (e.g., a score of 10 indicates greater concern for adverse health effects or greater potential to occur in drinking water, whereas a score of 1 indicates lesser concern). If a chemical had more than one data element available for scoring, EPA used a hierarchy to establish which data element should be used in scoring the potency attribute, the prevalence attribute and the magnitude attribute. For the potency and severity attributes, if data were available for both the cancer and noncancer endpoints, the higher of the cancer or noncancer potency scores was selected to score the potency and the critical effect associated with the data used to score the potency was used to score the severity. The attribute scoring protocols and data hierarchies are discussed in more detail in the Final Contaminant Candidate List 3 Chemicals: Classification of the PCCL to CCL (USEPA, 2009d) (see Appendix A for the Attribute Scoring Protocols). The classification models were calibrated using a training data set so that they mimicked an expert panel's decisions to list or not list a contaminant on the CCL. The training data set consisted of 202 sets of attribute scores for contaminants and the consensus category (list/not list decisions) made by a team of EPA subject matter experts based on evaluating the data and the attribute scores for those contaminants. The classification models developed a relationship between the contaminant attribute scores (input variables) and the classification of the contaminants into list and not list categories (output). The list and not list decisions were placed into four primary categories: List (L), List? (L?), Not List? (NL?) or Not List (NL). The L? and NL? categories were developed because the expert panel recognized that clear decisions on listing contaminants could be made easily for some contaminants, but there was some uncertainty associated with the decision for other contaminants. The L? category signifies that the decision is leaning towards listing with some uncertainty, and NL? signifies that the decision is leading towards not listing, but with some uncertainty. EPA used three classification models and each model produced a prediction for each PCCL contaminant. EPA used an additive process to combine the results of all three models. If all three models were in 100% agreement on the categorical prediction, one of the four primary categorical predictions (L, L?, NL? or NL) was assigned to that contaminant. If all three models did not agree, then the contaminant was assigned to a category in between the four primary categorical predictions. None of the models categorized a contaminant more than one category higher or lower than the other models (i.e., no contaminants were categorized by an "L" by one model and by an "NL?" by another model). There are three "in between" categories including: L?-L, NL?-L? or NL-NL?. An example of a contaminant that would be placed in an "in between" category is if one model placed the contaminant into the "L" category and the other two models placed it into the "L?" category, then it would be placed in the "L?-L" category. As part of the last stage in the CCL 3 classification process, the model output was reviewed by internal EPA experts and based upon issues identified by the reviewers, several post-model refinements were added by EPA to the CCL 3 process. One important refinement that was added to the process was that for contaminants with water data, EPA calculated the ratio between the health reference level (HRL) and the 90* percentile concentration level in water. If a 90* percentile (of detections) concentration level was not available, the agency used the maximum or Page 4 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants next highest percentile reported value. This HRL to concentration ratio was calculated for all contaminants with water data and serves as a benchmark that suggests a greater concern if the ratio is low (concentration close to the HRL) and a lesser concern when the ratio is high (concentration well below the HRL) . If the ratio was less than 10, the contaminant was typically selected for listing on the CCL 3. If the ratio was greater than 10, the contaminant was typically not listed on the CCL and remained on the PCCL. For contaminants that had limited finished water data, but more robust ambient water monitoring data, the ambient water concentration was used to develop the ratio. If no measured water data were available EPA used modeled water data for pesticides (Estimated Environmental Concentrations (EECs) developed by EPA's Office of Pesticide Programs (OPP)), when available, to calculate the HRL to concentration ratios. For contaminants with no water data (either measured or modeled) HRL to concentration ratios could not be calculated. For these contaminants (e.g., contaminants that only had release data for occurrence), if the three-model categorical prediction was L, L?-L or L?, the contaminant was typically listed on the CCL. Another important post-model refinement included in the CCL 3 process considered the nature of the best available data. Some chemicals on the PCCL were represented by only an LDso value for health effects data and/or only production volume data for occurrence. These data are not typically sufficient for a contaminant to be included on the CCL. In such cases, the chemical was not included on the CCL and remained on the PCCL. 3.0 CCL 4 Chemical CISs Explanation This section presents a walk-through of the CISs with a brief explanatory discussion of the data elements on the CIS and how they are used in the CCL process. The CIS for each contaminant is a concise, two-page profile with the first page including the attribute scores, three model categorical predictions, HRL/concentration ratios, use information, status of the contaminant in the CCL process and health effects data. The second page includes occurrence data. (The derivation and use of these data are explained in detail in Final Contaminant Candidate List 3 Chemicals: Classification of the PCCL to CCL (USEPA, 2009d).) For the chemical CISs for the nominated contaminants that made the PCCL 4, please see Appendix A. General and Summary Information The top section of the first page of each chemical CIS contains seven sets of information that includes contaminant identifiers, use and how the chemical was scored and ranked in the CCL process. From left to right, the upper rows include: 1) Contaminant Identification - the contaminant name, a unique CCL-specific identification number referred to as a Substance Key (many of which were obtained from EPA's Substance Registry System, now known as Substance Registry Services (SRS); others were assigned during the CCL process if a contaminant was not listed in SRS), and the contaminant's Chemical Abstract Services Registry Number (CASRN). Page 5 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants 2) Attribute Scores - assigned scores for each of the four CCL attributes (which are derived from the health effects and occurrence data presented on the CISs), which are defined as follows: a. Potency - Potency reflects the lowest dose of a chemical that causes an adverse health effect. Potency for chemicals is reflected in several standard toxicological parameters, including the Reference Dose (RfD) or its equivalent; cancer potency, expressed as the concentration in water equivalent to a 10~4 cancer risk; No Observed Adverse Effect Level (NOAEL); or Lowest Observed Adverse Effect Level (LOAEL). b. Severity - Severity is the adverse health effect associated with the dose that is used as the measure of Potency and is calibrated based on the health-related significance of the adverse effect (e.g., dermatitis versus cancer). c. Prevalence - Prevalence is a measure of how widespread the contaminant's occurrence is in the environment (specifically in the United States). The data used to score the prevalence attribute may include the percent of public water systems or monitoring sites with detections of the contaminants, the number of States where pesticides are applied or where releases to the environment are reported or chemical production data in pounds per year (Ibs/year). d. Magnitude - Magnitude relates to the quantity of a contaminant that may be found in the environment. This may be measured through the use of the median value concentration of detections in drinking water or ambient water or the total pounds of a chemical released to the environment. In cases where Magnitude data are not available, persistence and mobility data (i.e., chemical property/environmental fate parameters) were used as surrogates for water occurrence or release data (see USEPA, 2009d for discussion). 3) Health Reference Level (HRL) - Separate HRLs are calculated for non-cancer and carcinogenic effects. The HRLs are expressed as a concentration of a contaminant in drinking water (expressed in micrograms per liter, |ig/L). If potency is scored on cancer data, that data is used to calculate the cancer HRL. If the potency attribute is scored on non-cancer data, the highest ranking cancer data element is used to calculate the cancer HRL. For cancer, an HRL can be derived either from a slope factor or from a 10~4 cancer risk. For carcinogens, the HRL is the one-in-a-million (10~6) cancer risk expressed as a drinking water concentration (in |ig/L). If potency is scored on non-cancer data, that data is used to calculate the non-cancer HRL. If the potency attribute is scored on cancer data, then the non-cancer HRL is calculated using the highest ranking non-cancer data element. For non-cancer effects the HRL can be derived from an RfD (or its equivalent), a LOAEL, or a NOAEL. For non- carcinogens, the HRL is obtained by multiplying the RfD times 70 kg (default body weight), dividing by a water intake of 2 L/day and multiplying by a 20% relative source contribution. If a NOAEL or a LOAEL was used for the HRL calculation the equation is the same as with an RfD, but default uncertainty factors are applied to the NOAEL or LOAEL to develop an RfD-like value (1,000 for a NOAEL and 3,000 for a LOAEL). Page 6 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants 4) HRL/Concentration Ratios - The HRL/concentration ratios are presented using the 90* percentile concentration occurrence value, if available, or the next highest percentile value or the maximum concentration of detections. Both the non-cancer HRL/ concentration ratio and the cancer HRL/concentration ratio were calculated (if applicable). The data used to develop the ratio is noted on the CIS. Moving down the CIS to the next set of three data elements; from left to right are presented: 5) Use - Use information for the contaminant. 6) Three-Model Categorical Prediction - As noted in Section 2.0 above, three calibrated classification models were used to generate Categorical Predictions based on the contaminant's attribute scores. There are four primary Categorical Predictions: L, L?, NL? and NL. One of these four primary Categorical Predictions was assigned to a contaminant if all three models were in agreement on the categorical prediction. If the three models were not in agreement, the contaminant was assigned to a category in between the four primary categories. There are three "in-between" categories including: L?-L, NL7-L? orNL-NL?. 7) Status - Presents the status of the contaminant with respect to having been listed on CCL 3 and its status within the CCL 4 process (i.e., was it included in the CCL 4 Universe, PCCL 4 or Draft CCL 4). Health Effects Data The remainder of the first page of the CISs presents the available health effects data for each contaminant. Non-cancer data elements are presented first followed by cancer data elements. Both the non-cancer and cancer data elements are generally presented in order according to the data hierarchy developed for scoring the potency attribute (with the highest ranking data elements used for scoring generally being presented closer to the top of the page and the lower ranking elements closer to the bottom of the page). The non-cancer data are presented before the cancer data. The column headings summarize the data element, the data source acronym, the numerical value (or qualitative, for cancer classification), units and the year associated with the data element. Typically the year is the date of publication of the data, although given the variability of the data sources' formatting it may represent a toxicological study date or the date when the data source website was last updated. If available, the critical effect is noted and a notes field is filled in if toxicological study data or other pertinent information for a particular data element is available. For non-cancer data elements the highest data element in the hierarchy for scoring Potency is the RfD, NOAEL or LOAEL from various sources, with EPA's Office of Pesticide Programs and Integrated Risk Information System (IRIS) values taking precedence over values from other agencies or the best available NOAEL or LOAEL from a published study. Below the non-cancer values are the cancer values, if applicable. As with the non-cancer values, they are presented in hierarchical fashion. For cancer the 10"4 cancer risk, typically from EPA's Health Advisory Tables (HAs) or IRIS, is the highest-ranking cancer data element followed by the slope factor. The 10"4 cancer risk or the slope factor is used for Potency scoring, where Page 7 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants applicable. In addition, qualitative cancer data, including cancer classifications from EPA, the International Agency for Research on Cancer (IARC), the U.S. National Toxicology Program (NTP) and/or California's Office of Environmental Health Hazard Assessment (OEHHA) are presented, although not quantitative, such values were incorporated into the PCCL screening process. The row for the data element used for scoring the Potency and Severity attributes is shaded grey on the CIS. At the bottom right of the health effects data section of the CIS are other supporting qualitative and quantitative data. These data represent the listing of contaminants as carcinogens and/or reproductive toxins or values that are protective of public health via the ingestion of drinking water (e.g., EPA Drinking Water Exposure Levels (DWELs), EPA HAs, World Health Organization (WHO) Guideline Values, and Health Canada Guideline Values). Occurrence Data The second page of the CISs is focused on occurrence data. The occurrence data are generally presented in order of the hierarchy established for scoring Prevalence and Magnitude (i.e., finished water data are at the top of the page, followed by ambient water data, supplemental water data (often studies from individual States or the primary literature), and application/release data, with production data and environmental fate parameters at the bottom of the page). Finished water occurrence data is the highest ranking data element in the hierarchy used to score the prevalence and magnitude attributes since it represents the best estimation of the potential for human exposure. The row for the occurrence data element used for scoring Prevalence and Magnitude is shaded grey on the CIS. The column headers for the water occurrence data include the data source; the number of total public water systems (PWS)/sites/samples; the number of positive results (referred to as "detects"), an indication as to whether the preceding values correspond to the number of PWSs, sampling sites or samples; the percent of detects, and where available; the minimum, maximum, median, 90* percentile, 99* percentile of detects; units; sampling year(s) and a notes field. Following the water data are data that are used to estimate potential occurrence in water in the absence of water data. These include application rate data for pesticides in Ibs/year, environmental release data to surface water and total environmental releases in Ibs/year. Following the application/release data are production data ranges for the most recent year for which data were available at the time of CCL 4 data collection. The final section of the CISs includes available environmental fate parameters with persistence metrics of half-life and a degradation code that is either based on structural modeling or the half- life. The remaining properties relate to environmental mobility. Page 8 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants 4.0 Summary of the Microbes Classification Process from the PCCL to CCL and CISs Explanation This section briefly describes the process developed under CCL 3 to select microbial contaminants from the PCCL for the CCL 3 and explains the elements included in the microbial CISs. The same process developed for CCL 3 was used to evaluate the nominated contaminants for the Draft CCL 4. A detailed description of the process developed to select microbial contaminants for the CCL 3 is provided in Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process (USEPA, 2009g). Microbes are evaluated for their occurrence in water and their ability to cause adverse health effects in humans. Pathogens on the PCCL were scored for placement on the CCL using a scoring system to assign a numerical value to each pathogen and rank the pathogens based upon their occurrence, health effects and waterborne disease outbreaks (WBDO). Those microbes receiving high scores were considered for placement on the CCL. Each microbe was scored using three scoring protocols, one protocol each for WBDO, occurrence in water and health effects. The highest of the individual WBDO score or occurrence score is added to the normalized health effects score to produce a composite pathogen score. Although the composite score is not shown on the CISs, the scoring summary table at the top left corner of each CIS shows the values used to calculate the composite score. The formula for calculating the final score is: highest score between the WBDO and occurrence score + [(general population health effects score + highest sensitive population health effects score) x 5/14]. EPA developed three scoring protocols for CCL 3 to define a hierarchy of the relevance that each of these types of data (e.g. occurrence in water, WBDO and health effects) provide in evaluating microbes for the CCL. WBDOs are scored on a five-level hierarchy ranging from never caused a WBDO (score of 1) to two or more documented WDBOs in the U.S. (score of 5). Occurrence is scored on a three-level hierarchy ranging from not detected in the U.S. (score of 1) to detected in drinking water in the U.S. (score of 3). Combining WBDO information and occurrence information allowed EPA to consider: 1) pathogens that are tracked by public health surveillance programs (i.e., CDC's Morbidity and Mortality Weekly Report) and 2) pathogens that are not yet tracked by public health surveillance programs but for which occurrence information is available (e.g., emerging pathogens). The health effects scoring protocol evaluates the extent of illness produced in humans from drinking water. These scores reflect the most common clinical presentation and are based on data from recent clinical microbiology manuals. The severity of disease manifestations produced by a pathogen is evaluated across a range of potential endpoints. The seven-level hierarchy developed for this protocol begins with mild, self-limiting illness (score of 1) and progresses to death (score of 7). For more information on the microbes scoring process, please see Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process (USEPA, 2009g). The scoring tables developed for CCL 3 were updated for each nominated contaminant. Since no new relevant data/information was found by EPA, nor provided by the nominators, the data supporting the respective scores for CCL 3 remain the same. The references in the scoring tables Page 9 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants were updated to reflect references that became available after EPA published the final CCL3. The table presents the final scores for each of the data types under consideration and a brief description of the data used to assign those scores with their respective references. For the microbial CISs, please see Appendix B. Elements of each scoring table include: 1) Scoring Summary - shows the scores used to calculate the final composite score for each microbial contaminant which include: highest score between the WBDO and occurrence, health effects score for the general population and highest health effects score of the sensitive subpopulations. 2) Data Table - shows the categories for each potential score, the scoring data, if applicable, and reference(s) used to support a particular score. The highest ranking score for each of the three scoring categories is bolded. The WBDOs scoring results is presented first, followed by the occurrence results and the health effects. 3) References - presents the full references for the data presented in the table. 5.0 References USEPA. 2009a. Drinking Water Contaminant Candidate List 3-Final. Federal Register. Vol. 74, No. 194, p. 51850, October 8, 2009. USEPA. 2009b. Final Contaminant Candidate List 3 Chemicals: Identifying the Universe. EPA 815-R-09-006. August 2009. USEPA. 2009c. Final Contaminant Candidate List 3 Chemicals: Screening to a PCCL. EPA 815- R-09-007. August 2009. USEPA. 2009d. Final Contaminant Candidate List 3 Chemicals: Classification of PCCL to the CCL. EPA 815-R-09-008. August 2009. USEPA. 2009e. Final Contaminant Candidate List 3 Microbes: Identifying the Universe. EPA 815-R-09-004. August 2009. USEPA. 2009f. Final Contaminant Candidate List 3 Microbes: Screening to the PCCL. EPA 815-R-09-0005. August 2009. USEPA. 2009g. Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. August 2009. USEPA. 2009h. Contaminant Information Sheets for the PCCL Chemicals Considered for CCL 3. EPA 815-R-09-014. August 2009. Page 10 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft PCCL 4 Nominated Contaminants USEPA. 2012. Request for Nominations of Drinking Water Contaminants for the Fourth Contaminant Candidate List. Federal Register. Vol. 77, No. 89. p. 27057, May 8, 2012 USEPA. 2014a. Announcement of Preliminary Regulatory Determination for Contaminants on the Third Drinking Water Contaminant Candidate List. Federal Register. Vol. 79, No. 202, p. 62716, October 20, 2014. USEPA. 2014b. Protocol for the Regulatory Determinations 3 Including Appendices A-F. EPA 815-R-14-005. April, 2014. USEPA. 2015a. Summary of Nominations for the Fourth Contaminant Candidate List. EPA 815- R-15-001. January, 2015. USEPA. 2015b. Data Sources for the CCL 4. EPA 815-R-15-004. January, 2015. USEPA. 2015c. Screening Document for the Draft PCCL 4 Nominated Contaminants. EPA 815- R-15-002.January, 2015. Page 11 of 11 ------- EPA-OGWDW Contaminant Information Sheets (CISs) for the EPA 815-R-15-003 Draft Preliminary PCCL 4 Nominated Contaminants Appendix 1: Chemical Contaminant Information Sheets The following 40 pages contain tables with health effects and occurrence information for the 20 chemical contaminants nominated by the public that were included on PCCL 4 or CCL 4. Due to the technical limitations of this document Appendix, for further assistance with reasonable accommodation please contact Meredith Russell at Russell.meredith@epa.gov or 202-564-0814. PageA1-1 ------- al p ha-H exach I orocy cl ohexan e CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): alpha-Hexachlorocyclohexane 6535 31 9846 Attribute Scores Potency 7 Severity 8 Prevalence 4 Magnitude 3 Source HSDB Use Component of benzene hexachloride (BHC) former insecticide 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 56 ug/L Health Reference Level (HRL)1 cancer: 0.006 ug/L HRL/Concentration Ratio(s) NC HRL/NAWQA 90%: 949 CAR HRL/NAWQA 90%: 0.102 Status CCL 3: Yes CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10*-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA IRIS OEHHA RAIS HE EPA IRIS I ARC Source NTP Value 0.008 1.2 Value o.oooe 2.7 6.3 B2 2B Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units rng/L (mg/kg-d)"1 (mg/kg-d)"1 Female Rat Date 9/2003 1991 Date 1988 2005 1986 1986 Male Mouse Critical Effect Hepatic Biochemical - Enzyme inhibtion, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.), Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Notes Basis NOAEL 0.8 mg/kg-d; UF = 100. 30-day study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B. V., POB 21 1 , 1 000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 56,137,1991 Notes Other Supporting Data Source Value Units Notes Is contaminant or carcinogen.. list of EPA; RAIS; Yes OEHHA; I ARC Slope factor taken from Is the contaminant on a list of IRIS. reproductive toxins? Drinking Water E (DWEL) Female Mouse quivalent Level EPA HA mg/L Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-2 ------- al p ha-H exach I orocy cl ohexan e CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 7,119 21 Sites Sites 0.30% 0.0004 0.21 0.011 0.059 0.21 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data Toccalinoetal., 2010 STOrage and RETrieval (STORE!) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 512 2,785 Amount Released 1 448 Units Ibs/yr Ibs/yr Ibs/yr Amount Range No Reports Units Ibs/yr Samples Sites Number of States Date 2002 0.2% 16.09% Units States States States 0.0327 0 Date 1997 2010 2010 0.0327 0.617 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.0327 0 0.0327 0.0038 0.0327 0.0656 ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1993-2007 Updated 201 3 Source OPP Value 1.2 DST 641-1,995 3.8 6.7E-06 2 7 Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes years DST = Degrades sometimes/recalcitrant; hydrolysis only, pH = 7 (HSDB) L/kg dimensionless L/kg atm-rrp/mol mg/L % Page A1-3 ------- Manganese CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Manganese 18823 7439965 Attribute Scores Potency 4 Severity 1 Prevalence 10 Magnitude 9 Source HSDB Use Manufacturing of stee matches, glass, dyes, animal food additives alloys, in dry-cell batter fertilizers, welding rods, es, electrical coils, ceramics, as oxidizing agents, and as 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 300 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NCHRL/NIRS90%: 2.4 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lowest Observed Adverse Effect Level (LOAEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE IOM ATSDR JMPR CEDI ADI ITER CTD JPN RTECS Supplemental Supplemental HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA IRIS I ARC Source NTP Value 0,047 0.14 0.16 10 7 Value D Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Date 1995 2004 2001 2009 2010 Date 1988 Male Mouse Critical Effect 1 1 mg/day = Upper Limit, amount of manganese in typical Western diet for adults (NOAEL) 15 mg/kg- day LOAEL increased serum manganese and manganese dependant lymphocyte SOD activity - Concern for neurotoxicity Neurodevelopmental effects in mice (Moreno et al, 2009a). Significant increase in Nitre Oxide Synthase 2 expression in brain of animals exposed as juveniles and adults (Moreno et al, 2009b). Impaired spontaneous motor activity in rats Notes Female Mouse Notes Reflects a modifying factor of 3 to adjust from increased bioavai lability when in drinking water The 3-fold modifying factor for b oavailability from drinking water was applied when calculating HA rather than in determining the RfD Not adjusted for the ncreased b oavailability from drinking water Moreno et al, 2009a. Aged-Dependent Suscept bility to Manganese-Induced Neurological Dysfunction. Toxicological Sciences 1 1 2(2): 394-404. Moreno et al, 2009b. Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of of Glia and Neuronal Protein Nitration. Toxicological Sciences. 112: 405-415. Kern et al, 2010. Preweaning Manganese Exposure Causes Hyperactivity, Disinhibition, and Spatial Learning and Memory Deficits Associated with Altered Dopamine Receptor and Transporter Levels. Synapse. 64: 363-378. Other Supporting Data Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level (DWEL) Guideline Value (GV) Health Advisory (HA) Source EPA HA WHODWQ EPA HA Value 1.6 0.4 0.3 Units mg/L mg/L mg/L Notes 2011 The 3-fold modifying factor for bioavailability from drinking water was applied when calculating HA rather than in determining the RfD Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-4 ------- Manganese CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) 989 672 PWS PWS PWS PWS 67.95% 1 1,341 11.96 126 673 ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 8,002 6,447 Sites Sites 80.57% 0.051 70,000 19 180 1,300 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data Toccalinoetal., 2010 California Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data North Carolina Drinking Water Monitoring Data Ohio Drinking Water Monitoring Data Region 9 Tribes Drinking Water Monitoring Data Texas Drinking Water Monitoring Data Wisconsin Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Massachusetts Nominations Data Minnesota Nominations Data Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 808 4,969 1,223 2,382 775 154 6,713 1,946 1,158 47,550 4,976 1,630 Amount Released 84,545 15,872,968 543 2,229 685 1,265 641 63 3,898 1,571 917 42,222 1,589 Units Ibs/yr Ibs/yr Ibs/yr Amount Range 500M - < 1 B Units Ibs/yr Samples PWS PWS PWS PWS PWS PWS PWS Sites Sites Samples Samples Number of States 31 48 Date 2006 67.2% 44.9% 56% 53.1% 82.7% 40.9% 58.1% 80.7% 79.2% 88.79% 97.48% Units States States States 0.053 0.001 1 0.7 0.113 0.85 1 0.006 0.1 0 0.1 Date 1997 2010 2010 1,923 35,000 2,700 239,000 216,000 320,000 25,910 400,000 37,000 18,604,000 28,000 3,000 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 8.99 70 31 28 33 80 10 28 2 51 7 110 186 380 190 175 246 592 70 358 220 393 360 500 732 1,455 378 779 1964 239,860 290 7,000 2,386 7,490 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1993-2007 1995-2007 1998-2005 1998-2005 1998-2005 1998-2005 1998-2005 1980-2012 2004-201 1 Updated 201 3 Source OPP Value persistent Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Ground Water; Mixed Public and Private Water Supplies; Received from Massachusetts for the CCL 4 nominations; Ayotte, J. D., J. M. Gronberg, etal. (2011). Trace Elements and Radon in Groundwater Across the United States. U.S. Geological Survey Scientific Investigations Report 201 1-5059: 115. (Source water for public supply wells from the Ayotte et al., 2011 overlaps with Toccalino etal., 2010.) Ground Water; Mixed Public and Private Water Supplies; Received from Minnesota for the CCL 4 nominations Value Date Units days L/kg dimensionless L/kg atm-rrp/mol mg/L % Notes As elemental Mn Page A1-5 ------- Methyl tert-butyl ether CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Methyl tert-butyl ether 11918 1634044 Attribute Scores Potency 4 Severity 8 Prevalence 5 Magnitude 8 Source Use Octane booster n gasoline; manufacture of sobutene; extrs action solvent 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 2,100 ug/L Health Reference Level (HRL)1 cancer: 19.4 ug/L HRL/Concentration Ratio(s) NC HRL/UCMR 90%: 58.3 CAR HRL/UCMR 90%: 0.539 CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA I ARC Source NTP Value 0.3 0.01 300 Value 0.0018 3 Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-dr (mg/kg-d)"1 Female Rat Date 8/1996 1991 1990 Date 2005 1999 Male Mouse Critical Effect Hepatic: Decreased blood urea nitrogen levels. Kidney, Ureter, Bladder - changes in bladder weight, Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol), Nutritional and Gross Metabolic - changes n calc um Notes 1 Notes Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of OEHHA Yes carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-6 ------- Methyl tert-butyl ether CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR 1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) 3,871 19 PWS PWS PWS PWS 0.49% 5 49 9.2 34.6 48.75 ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 4,328 424 Sites Sites 9.80% 0.01 23,000 0.3 7.85 1,800 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data Toccalinoetal., 2010 California Drinking Water Monitoring Data Florida Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data Ohio Drinking Water Monitoring Data Region 9 Tribes Drinking Water Monitoring Data Texas Drinking Water Monitoring Data Wisconsin Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 832 4,419 31 1,161 1,306 219 5,660 1,142 1,855 1,210 Amount Released 800 1,471,221 Amount Range >1B 115 150 7 26 6 1 41 38 101 154 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr Samples PWS PWS PWS PWS PWS PWS PWS Sites Sites Number of States 6 35 Date 2006 13.8% 3.4% 22.6% 2.2% 0.5% 0.5% 0.7% 3.3% 5.4% 12.73% Units States States States 0.031 0.15 0.09 0.5 0.5 9.8 0.5 0.104 0.03 0.046 Date 1997 2010 2010 12.03 610 67.18 16 9.51 9.8 48 64.9 28.3 13,000 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.173 5.96 0.755 1.3 1.21 9.8 2.8 2.2 0.12 1.5 1.07 33 4.56 7 5.36 9.8 10.2 16.6 0.554 14.5 7.76 214 51.2 16 8.55 9.8 25.6 45.9 2.17 1,600 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1993-2007 1995-2007 2004-2007 1998-2005 1998-2005 1998-2005 1998-2005 1980-2012 2004-201 1 Updated 201 3 Source OPP Value 15 BS 6 0.94 5.87E-04 51,000 42 Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes days BS = Biodegrades slow (PBT) L/kg dimensionless L/kg atm-rrp/mol mg/L % Page A1-7 ------- Microcystin-LR CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Microcystin-LR 76859 101043372 Attribute Scores Potency 9 Severity 3 Prevalence 10 Magnitude 4 Source Use Use Naturally-occurring cyanobacterial toxin 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 0.021 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/AWWARF Typical Range MAX: 0.21 Status CCL 3: Yes CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) Reference Dose (RfD)-like value No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER Primary Literature CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA I ARC Source NTP Value 0.000003 Value Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-1 Female Rat Date 200S Date Male Mouse Critical Effect Liver effects Notes Female Mouse Notes Draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y, Y. Makita, S. Nagata et al., 1998. No chronic oral toxicity of a low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female Balb/C mice. Environ. Toxicol. 1 4(1): 45- 55. Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-8 ------- Microcystin-LR CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data STOrage and RETrieval (STORE!) US and Canadian drinking water (bloom area, source, finished water) US and Canadian drinking water (bloom area, source, finished water) Application/Release Data National Center for Food and Agricultural Policy (NCFAP)- Application . /-rnl\ <^ Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 30 677 677 Amount Released Amount Range 30 542 542 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr Sites Sites Sites Number of States Date 2006 100% 80% 80% Units States States States 0 0.002 Date 1997 2010 2010 4.26 1,200 0.1 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.25 1.22 3.32 ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water Updated 201 3 Source OPP Value Vlaximum and min mum of detects (AWWARF, Carmichael). ncludes possible outliers. Vlaximum of typical range of detects (AWWARF, Carmichael). Excludes possible outliers. Value Date Units Notes length of time Degradation Code Not Available L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-9 ------- Nonylphenol CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Nonylphenol 28410 251 54523 Attribute Scores Potency 5 Severity 7 Prevalence 10 Magnitude 6 Source HSDB Use In the preparation of lubricating oil additives, resins, plasticizers, surface active agents; antioxidants for plastics and rubber 3-Model Categorical Prediction L?-L Health Reference Level (HRL)1: 105 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/Kolpin Max: 2.6 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) No Observed Adverse Effect Level (NOAEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN Supplemental RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA I ARC Source NTP Value 60 15 2 580 Value Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Date 2004 2001 Date Male Mouse Critical Effect Reproductive effects Endocrine - androgenic, Reproductive - Paternal Effects - testes, epididymis, sperm duct Details of toxic effects not reported other than lethal dose value Notes World Health Organization (WHO) REPTED Reproductve Toxicology. (Pergamon Press Inc., Maxwell House, FairviewPark, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year 15,293,2001 NTIS National Technical Informaton Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year OTS0573098 Notes Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-10 ------- Nonylphenol CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data Kol pin etal., 2002 STOrage and RETrieval (STORET) Snyder, 2008 Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 85 15 20 Amount Released Amount Range <500K 43 5 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr Sites Sites Samples Number of States Date 2006 50.6% 33.33% 17% Units States States States 3.26 Date 1997 2010 2010 40 5.17 0.104 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0,8 3.74 0.084 4.52 5.11 ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1999-2000 Updated 201 3 Source OPP Value BST 31,000 5.71 1.1E-06 6.35 18 Mational Surface Water Reconnaissance; Kolpin, etal., 2002. Env. Sci, &Technol., 36(6), pp. 1202-1211. =inished Drinking Water Monitoring; Snyder, Shane A. 2008. Ozone: Science and Engineering. 30(1): 65-69. Value Date Units Notes days BST = biodegrades sometimes/recalcitrant; aerobic only L/kg dimensionless At 20 degrees Celsius L/kg atm-nf/mol mg/L At 25 degrees Celsius % Page A1-11 ------- Perfluorooctanoic acid (PFOA) CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Perfluorooctanoic acid (PFOA) 6614 335671 Attribute Scores Potency 6 Severity 3 Prevalence 10 Magnitude 6 Source HSDB Use Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire- fighting applications, cosmetics, greases and lubricants, paints, polishes and adhesives 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 1.1 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/MN MW MAX: 1.22 Status CCL 3: Yes CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS Supplemental HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA I ARC Source NTP Value 0.4S Value Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Date 2008 Date Male Mouse Critical Effect Increased maternal liver weight at term Notes Female Mouse Notes BMDL10, Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA: http.7/www.epa.gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Health Advisory (HA) EPA HA 0.4 ug/L January 2008; Provisional Health Advisory: http://www.epa.gov/waterscience/criteria/drinkin g/pha-PFO A_PFOS.pdf Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-12 ------- Perfluorooctanoic acid (PFOA) CCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data STOrage and RETrieval (STORET) Minnesota (MN) Department of Health (DOH) - Aggregate of MN Wells Minnesota (MN) Department of Health (DOH) - Select MN Municipal Wells Minnesota (MN) Department of Health (DOH) - Select MN Non-Community Wells Minnesota (MN) Department of Health (DOH) - Select MN Private Wells Little Hocking, OH Municipal Wells (FW) NJDEP Cape Fear Drainage Basin Upper Mississippi Drainage Basin Tennessee River, Alabama U.S. PWS Study Lake Erie and Lake Ontario Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total 318 85 37 22 26 23 80 175 40 6 16 Amount Released 232 7 6 0 1 18 168 18 16 Units Ibs/yr Ibs/yr Ibs/yr Sites Sites Sites Sites Sites N/A Sites Sites Sites Sites Sites Sites Number of States Production Chemical Update System/Inventory Update Reporting (CUS/IUR) Amount Range <500K Units Ibs/yr Date 2006 72.96% 8.2% 16.2% 0% 3.9% 78.3% 82.3% 97.1% 45% 100% Units States States States 0.000988 1.5 0.004 0.14 O.005 0.015 Date 1997 2010 2010 48,500 0.9 0.9 0.67 7.2 0.039 0.287 0.125 0.598 0.12 0.07 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.144 0.0126 0.00207 0.379 0.04 47.7 1,304 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water Updated 201 3 2006 2008 2003 Source OPP Value BST 631 ± 7.9 0.091 10 Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals n Minnesota, MN DOH, 2/27/06. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Targeted Sampling 2004-2005 - H. Goeden and J. Kelly. Perfluorochemicals in Minnesota, MN DOH, 2/27/06. Emmett, etal., 2006. J. Occ. Env. Med. Little Hocking, OH; data from 2002-2005; no data on # PWSs/sites sampled Targeted study "Determination of Perfluorooctanoic Acid (PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP, Division of Water Supply. Makayama et al. 2007. Perfluorinated Compounds in the Cape Fear Drainage Basin in N.C. Env. Sci. & Tech., 41 , 5271-5276. Makayama et al. 2010. Determination of Perfluor nated Compounds in the Upper Mississippi River Basin. Env. Sci. & Tech., 44, pp. 4103-4109. Targeted sampling - 35 river miles downstream of PFC manufacturing facility. Hansen et al. 2002. Quantitative Characterization of Trace Levels of PFOS and PFOA in the Tennessee River. Env. Sci. &Tech., 36, pp. 1681-1685 Quinones, O. and S.A. Snyder. 2009. Occurrence of oerfluoroalkyl carboxylates and sulfonates in drinking water utilities and related waters from the United States. Env. Sci. & Tech., 43, pp. 9089-9095. Boulanger et al. 2004. Detection of Perfluorooctane Surfactants in Great Lakes Water. Env. Sci. & Tech., 38, pp. 4064-4070. Value Date Units length of time L/kg dimensionless L/kg atm-nf/mol mg/L % Notes BST = Biodegrades sometimes/recalcitrant (PBT); BST is the highest category available to be awarded to a recalcitrant contaminant Zareitalabad, etal., 2013 Page A1-13 ------- Permethrin CCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Permethrin 35815 52645531 Source HSDB Use Insecticide Attribute Scores Potency Sev 4 E srity Prevalence 10 Magnitude 7 3-Model Categorical Prediction L?-L Health Reference Level (HRL)1: 1,750 ug/L Health Reference Level (HRL)1 cancer: 3.65 ug/L HRL/Concentration Ratio(s) NC HRL/SWC EEC: 1,944 CAR HRL/SWC EEC: 4.05 CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Fa,ctor (Oral) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA EPA OPP OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0.25 0.05 0.05 0.2 0.05 Value 0.0096 Likely 3 Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)- (mg/kg-d)-' (mg/kg-d)-' Female Rat Date 2009 1986 1986 2003 1999 Date 2009 2009 1991 Male Mouse Critical Effect Neurotox/Clinical signs (i.e., aggression, abnormal and/or decreased movement) and ncreased body temperature. Q1 * 0.0096 (mg/kg-d)-1 . See CAR Increased liver weight Neurol. Notes Female Mouse Notes Basis NOAEL = 25 mg/kg-d, UF = 100 (rat study) Basis = NOEL 5 mg/kg-d; UF = 100. Minimal Risk Level - Intermediate Exposure Duration Other Supporting Data Source Value Units Notes Is contaminant on list of EPA; IARC Yes carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-14 ------- Permethrin CCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Centerfor Food and Agricultural Policy (NCFAP) - Application Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 35 1,828 722 Amount Released 1,066,056 0 2,116 0 0 1 Units Ibs/yr Ibs/yr Ibs/yr Amount Range Units Ibs/yr PWS Sites Sites Number of States 48 0 5 Date 2006 0% 0% 0.14% Units States States States 0.348 Date 1997 2010 2010 0.348 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.348 0.348 0.348 ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1995-2007 2004-201 1 Updated 201 3 Source OPP Value BF/BST 178,000 6.5 1.87E-06 0.006 6 Value Date SW Chronic = 0.9 ug/L; GW Chronic = 0 ug/L Units Notes length of time BF = Biodegrades fast; BST = Biodegrades sometimes/recalcitrant L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-15 ------- Azinphos-m ethyl PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Azinphos-methyl 3200 86500 Attribute Scores Potency 6 Severity 3 Prevalence 8 Magnitude 3 Source HSDB Use Insecticide 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 10.5 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NCHRL/NAWQA90%: 69.5 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0.0015 0.005 0.91 Value Not likely Male Rat Equivocal Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Negative Date 200S 1991 1997 Date 2006 Male Mouse Negative Critical Effect Red blood cell cholinesterase inhibition; increased incidence of diarrhea Brain and Coverings - other degenerative changes, Blood - other changes, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Notes Basis NOAEL = 0.149 mg/kg-d; UF = 100 (dog study) FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue)/page/year 35,101,1997; 13-wkrat study Notes Female Mouse Negative Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of UMD Yes reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Maximum Acceptable Concentration CADW 0.2 mg/L Canadian Drinking Water Maximum Acceptable (MAC) Concentration Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-16 ------- Azinphos-m ethyl PCCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 7,103 145 Sites Sites 2.04% 0.002 3.37 0.027 0.151 0.932 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Toccalinoetal., 2010 California Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 12 11 5 323 228 894 5 1,828 831 Amount Released 2,091,014 Amount Range 0 2 0 8 5 0 0 0 24 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Sites Sites Samples Samples Samples PWS Sites Sites Number of States 42 Date 2006 0% 18.2% 0% 2.5% 2.2% 0% 0% 0% 2.9% Units States States States 0.017 0 Date 1997 2010 2010 0.017 0.144 0.114 0.864 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.017 0.048 0.017 0.196 0.017 0.649 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 1993-2007 1995-2007 2004-201 1 Updated 201 3 Source OPP Value 27.9 DS 487-4,644 2.75 2.4E-08 20.9 27 Drinking water monitoring =inished Raw Ambient Water; Method 2001 (GC/MS) Finished Water; Method 2001 (GC/MS) Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes days DS = Degrades slow (HSDB) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-17 ------- Bentazon PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Bentazon 28242 25057890 Attribute Scores Potency 5 Severity 6 Prevalence 9 Magnitude 4 Source HSDB Use Former herbicide 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 210 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/NAWQA 90%: 276 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Value 0,03 0.03 0.03 0.03 0.1 Source EPA OEHHA RAIS HE EPA IRIS EPA OPP I ARC Source NTP Value E E Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)"1 (mg/kg-d)-1 Female Rat Date 1994 1998 1999 1989 1998 Date 1998 1994 Male Mouse Critical Effect Hematological changes suggestive of anemia, decreased weight gain, intestinal inflammation, and congestion of the small intestine and spleen (dog study) Blood loss into the gastrointestinal tract; Coagulation defect in male & female dogs. Circulatory system. blood loss in gastrointestinall tract; coagulation defect Notes UF = 100; Basis NOAEL = 3.2 mg/kg-day Allen etal., 1989. Dog study; UF = 100, Basis NOAEL 3.2 mg/kg-d UF = 100; dog study Notes Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Guideline Value (GV) WHODWQ 300 ug/L World Health Organization Drinking Water Guideline Value Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-18 ------- Bentazon PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 4,540 197 Sites Sites 4.34% 0.002 11.46 0.1 0.76 4.79 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Toccalinoetal., 2010 California Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data STOrage and RETrieval (STORET) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 5,583 13 7 589 1,807 1 694 Number 225 312 Amount Released 7,749,130 Amount Range 2 7 5 16 6 0 75 Number of Detects 21 80 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Sites Sites Samples PWS PWS Sites PWSs/ Sites/ Samples Samples Samples Number of States 45 Date 2006 0.04% 53.8% 71.4% 2.7% 0.3% 0% 10.81% Percent with Detects 9.3% 25.6% Units States States States 0.23 0.0003 0.0003 0.0046 0.023 0 Minimum Cone. (Detects) Date 1997 2010 2010 6.2 0.031 0.194 0.491 6.2 16 Maximum Cone. (Detects) 0.019 0.344 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 3.11 0.0016 0.0017 0.00995 2.9 0.191 Median Cone. (Detects) 5.58 0.00712 0.012 0.0711 5.24 2.13 75th Percentile (Detects 0.016 0.061 0.434 6.1 12.4 95th Percentile (Detects) 0.019 0.021 ug/L ug/L ug/L ug/L ug/L ug/L ug/L Cone. Units ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1993-2007 1995-2007 1998-2005 Updated 201 3 Date 1999 1999 Source OPP Value 6.7-50 BS 37.5 2.34 2.18E-09 500 36 Drinking water monitoring =inished Raw Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Notes Finished Water; Method 9060 (HPLC/MS) Ambient Water; Method 9060 (HPLC/MS) Value Date Units Notes days BS = Biodegrades slow (HSDB) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-19 ------- Bisphenol A PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Bisphenol A 2918 80057 Source HSDB Use Production of polycarbonate and epoxy resins. Formerly used as fungicide. Attribute Scores Potency Sev 4 : 3rity Prevalence 10 Magnitude 5 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 350 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/NREC NA SW MED: 1,750 Status CCL 4 Universe: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) No Observed Adverse Effect Level (NOAEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN Supplemental RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA I ARC Source NTP Value 0.05 0.05 0.0006 2.5 Value Male Rat Equivocal Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)"1 (mg/kg-d)"1 Female Rat Equivocal Date 1988 1988 2011 Date Male Mouse Equivocal Critical Effect Reduced body weight Increase in adjusted terminal end bud (TEB) numbers in the offspring of mice for LOAEL related to NOAEL Notes Basis = LOAEL 50 mg/kg-d; UF = 1,000 LOAEL = 0.003 mg/kg-d. Ayyanan, A., Laribi, O., Schuepbach-Mallepell, S. etal. 2011. Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number. Mol. Endicronol. 25(11): 1915-1923. 26-week oral study n rat. GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936 - Volume(issue)/page/year 33(7), 25, 1968. Notes Female Mouse Negative Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of UMD Yes reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-20 ------- Bisphenol A PCCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) 85 35 Sites Sites Sites Sites Sites 41.20% 21.07% 10.78% 0.14 0.2 0.2 ug/L ug/L ug/L ug/L ug/L 1992-2001 1999-2004 1999-2004 1999-2004 1999-2004 Surface water; National Reconnaissance Surface water; National Aggregate. Size of dataset not reported. Ground water; National Aggregate. Size of dataset not reported. Supplemental Water Data Kolpinetal., 2002 Focazioetal., 2008 Hopple etal., 2009 Hopple etal., 2009 Hopple etal., 2009 Kingsbury etal., 2008 Kingsbury etal., 2008 Kingsbury etal., 2008 STOrage and RETrieval (STORET) Stackelberg, etal., 2007 Stackelberg, etal., 2007 Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total 85 73 43 47 212 145 87 87 33 12 12 Amount Released 6,240 3,296,213 7 1 Units Ibs/yr Ibs/yr Ibs/yr Sites Sites Samples Samples Samples Samples Samples Samples Sites Samples Samples Number of States 5 27 Production Chemical Update System/Inventory Update Reporting (CUS/IUR) Amount Range >1B Units Ibs/yr Date 2006 41.2% 9.6% 2.3% 0% 0.9% 0% 9.2% 4.7% 3.03% 17% 67% Units States States States 0.28 Date 1997 2010 2010 12 1.9 2.5 6.4 0.44 0.67 0.28 0.22 0.36 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.14 0.28 0.28 0.28 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1999-2000 2001 2002-2005 2002-2005 2002-2005 2002-2005 2002-2005 2002-2005 Updated 201 3 Source OPP Value BFA-BST 75,200 3.32 9.2E-12 120 8 Mational Surface Water Reconnaissance; Kolpin Env. Sci. &Technol., 36(6), pp. 1202-1211. etal., 2002. NREC II Raw Drink ng Water; Focazio, et al., 2008. Sci. Tot. Env., 402(2-3), pp. 201-216. Ground water; Phase 2; Source water; Hopple et al., 2009, Anthropogenic organic compounds in source water of selected community water systems that use groundwater, 2002-05: USGS Sci. Investigations Report 2009-5200, p. 74 Ground water; Phase 2; Finished water; Hopple et al., 2009 Ground water; Phase 1; Source water; Hopple et al., 2009 Surface water; Phase 1 ; Source water; Kingsbury et al., 2008 Surface water; Phase 2; Finished water; Kingsbury et al., 2008 Surface water; Phase 2; Source water; Kingsbury et al., 2008, Anthropogenic organic compounds in source water of nine community water systems that withdraw from streams, 2002-05: USGS Sci. Investigations Report 2008-5208, p. 66 New Jersey Finished Drinking Water; Stackelberg, etal., 2007. Sci. Tot. Environ., 377(2-3), pp. 255-272. New Jersey Surface Water; Stackelberg, et al., 2007. Sci. Tot. Environ., 377(2-3), pp. 255-272. Value Units length of time L/kg dimensionless L/kg atm-nf/mol mg/L % Date Notes BFA = Biodegrades fast with acclimation; BST = Biodegrades sometimes/recalcitrant Page A1-21 ------- Butyl benzyl phthalate PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Butyl benzyl phthalate 3168 85687 Attribute Scores Potency 4 Severity 3 Prevalence 8 Magnitude 8 Source HSDB Use Chemics al intermediate Pis asticizer 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 1,400 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/TX90%: 63.1 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA EPA PPRTV OEHHA RAIS HE EPA IRIS I ARC Source NTP Value 0.2 0.2 0.2 1.3 100 Value 0.0019 C 3 Male Rat Some Evidence Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Female Rat Equivocal Evidence Date 1993 1989 1989 1998 2000 Date 2002 1988 1999 Male Mouse Not Tested Critical Effect Significantly increased liver-to-body weight and liver to-brain weight ratios Significantly increased liver-to-body weights liver- to-brain weight ratios Gastrointestinal - changes n structure or function of salivary glands, Kidney, Ureter, Bladder - changes in kidney weight; endocrine - other changes Notes NTP, 1 985. Basis NOAEL = 1 59 mg/kg-d; UF = 1 ,000 (rat study) NTP, 1985; Basis NOAEL/LEL, rat, liver, brain, UF=1000 Hammond et al. 1987; Basis BMD 132 mg/kd/day, UF = 100, rat oral study in rat; REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year 14,513,2000 Notes Vol. 73, 1999 Female Mouse Not Tested Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA 7 mg/L Drinking Water Equivalent Level (DWEL) Note: Highlighted data indicate value was used i 1 For the CCL process HRLs were calculated by 2 Cancer classifications were only used for screei n attribute scoring. Blank fields indicate there were no data available. converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. ming. For potency scoring quantitative cancer risk data were used. Page A1-22 ------- Butyl benzyl phthalate PCCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services California Drinking Water Monitoring Data Florida Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data Texas Drinking Water Monitoring Data STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 851 264 5 2 2,108 1,221 Amount Released Amount Range 50M-< 100M 24 16 0 0 4 248 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS PWS PWS PWS PWS Sites Number of States Date 2006 2.8% 6.1% 0% 0% 0.2% 20.31% Units States States States 0.004 0.003 3.97 0 Date 1997 2010 2010 124 8.5 28,4 629.5 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.2 0.074 8,99 0.043 59 4.3 22.2 0.97 8.4 26 27.2 ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1995-2007 2004-2007 1998-2005 1998-2005 Updated 201 3 Source OPP Value BF 9,359 4.73 1.26E-06 2.69 22 Drinking water monitoring Value Date Units Notes length of time BF = Biodegrades fast (BIODEG) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-23 ------- Carbaryl PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Carbaryl 2448 63252 Attribute Scores Potency 5 Severity 5 Prevalence 1 Magnitude 5 Source HSDB Use Insecticide; veterinary medication 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 70 ug/L Health Reference Level (HRL)1 cancer: 40 ug/L HRL/Concentration Ratio(s) NC HRL/UCM R2 90%: 70 CAR HRL/UCM R2 90%: 40 CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA EPA OPP OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0,01 0.1 0.01 0.008 0.23 Value 0.000875 Likely 3 Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)"1 (mg/kg-d)-1 (mg/kg-d)-1 Female Rat Date 2007 1985 2006 2001 1975 Date 2002, updated 2008 2007 1987 Male Mouse Critical Effect 0.01 mg/kg-day is the acute RfD based on brain cholinesterase inhibition PND 1 1 . Q1* 0.000875 (mg/kg-d)"-1 - Likely; see CAR Kidney; liver Immunological Including Allergic - decrease in humoral immune response Notes Basis NOAEL = 1 mg/kg-d, UF = 100 (rat study) Carpenter et al., 1961; Basis NOAEL 9.6 mg/kg/day, rat, UF=100, kidney Silver oral study in rabbit; TXAPA9 Tox cology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 32,587,1975 Notes Incidence of hemangiosarcomas in mice; 2002 and 2007 Carbaryl Occupational Risk Assessment in August 2008 Amended RED Likely to be carcinogenic in humans; 2003 and 2007 Carbaryl Occupational Risk Assessment in August 2008 Amended RED Vol. 12, Suppl. 7, 1987 Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of EPA; IARC Yes carcinogens? Is the contaminant on a list of UMD Yes Teratogen reproductive toxins? Drinking Water Equivalent Level EPA HA 0.4 mg/L 2006; Drinking Water Equivalent Level (DWEL) Maximum Acceptable Concentration CADW 0.09 mg/L Canadian Drinking Water Maximum Acceptable (MAC) Concentration Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-24 ------- Carbaryl PCCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) 12,678 13 PWS PWS PWS PWS 0,10% 0.18 3 0.18 1 3 ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) 7,142 85 697 14 Sites Sites Sites Sites 9.76% 16.50% 5.05% 0.12% 0.0005 33.5 0.0167 0.04 0.17 0.9 0.138 1.2 ug/L ug/L ug/L ug/L 1992-2001 1999-2004 1999-2004 1999-2004 Surface water; National Reconnaissance Surface water; National Aggregate. Size of dataset not reported. Ground water; National Aggregate. Size of dataset not reported. Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Toccalinoetal., 2010 California Drinking Water Monitoring Data Florida Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data North Carolina Drinking Water Monitoring Data Ohio Drinking Water Monitoring Data Region 9 Tribes Drinking Water Monitoring Data South Dakota Drinking Water Monitoring Data Wisconsin Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 4,671 7 13 323 312 228 225 898 1,488 8 22 2,477 43 232 256 1,447 1,831 1,213 Amount Released 4,857,542 12 1,653 Amount Range 1 5 5 7 2 2 0 6 2 0 0 2 0 0 0 1 1 21 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Sites Sites Samples Samples Samples Samples Samples PWS PWS PWS PWS PWS PWS PWS PWS Sites Sites Number of States 48 3 7 Date 2006 0.02% 71.4% 38.5% 2.2% 0.6% 0.9% 0% 0.7% 0.1% 0% 0% 0.1% 0% 0% 0% 0.1% 0.05% 1.73% Units States States States 3.5 0.0078 0.005 0.00277 3.5 22 1 0.007 0 Date 1997 2010 2010 3.5 0.33 0.3 0.047 0.063 0.041 0.0196 24 36 1 0.007 50 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 3.5 0.02 0.02 0.00736 13.8 29 1 0.007 0 3.5 0.092 0.16 0.0146 22 34.6 1 0.007 5.5 0.31 0.29 0.0191 23.8 35.9 1 0.007 38.3 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 1999 1999 1993-2007 1995-2007 2004-2007 1998-2005 1998-2005 1998-2005 1998-2005 1990-2007 1980-2012 2004-201 1 Updated 201 3 Source OPP Value 38 BSA 242 2.36 4.36E-09 110 13 Drinking water monitoring Raw =inished Ambient Water; Method 2001 (GC/MS) Ambient Water; Method 9060 (HPLC/MS) Finished Water; Method 2001 (GC/MS) Finished Water; Method 9060 (HPLC/MS) Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes days BSA = Biodegrades slow with acclimation L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-25 ------- Chlorothalonil PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Chlorothalonil 12375 1897456 Attribute Scores Potency 5 Severity 6 Prevalence 4 Magnitude 4 Source HSDB Use Fungicide; bacteriocide 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 140 ug/L Health Reference Level (HRL)1 cancer: 4.6 ug/L HRL/Concentration Ratio(s) NCHRL/NAWQA90%: 342 CAR HRL/NAWQA 90%: 11.2 CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN Supplemental RTECS HSDB CTD JPN RTECS Source EPA HA EPA EPA OPP OEHHA RAIS HE EPA OPP EPA I ARC Source NTP Value 0.02 0.015 0.015 0.015 0.03 1.5 75 Value 0.15 0.46 0.00766 0.0031 0.011 Likely B2 2B Male Rat Positive Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L mg/L (mg/kg-d)"1 (mg/kg-d)"1 (mg/kg-d)"1 Female Rat Positive Date 1999 1987 1988 1987 1994 1990 Date 1988 1999 1999 2005 1999 1988 1999 Male Mouse Negative Critical Effect Increased kidney weights & hyperplasia of the proximal convoluted tubules in the kidneys, ulcers Sforestomach hyperplasia. Q1* 0.00766 (mg/kgday)A-1 . Group B2. See CAR Renal tubular epithelial vacuolation Tubular epithelial vacuolat on Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis), Kidney, Ureter, Bladder - changes in bladder weight Notes Corresponds with OPP slope factor. Vol. 73, 1999; note: OEHHA lists lARCs cancer class as 3. Female Mouse Negative Notes Basis NOAEL = 2 mg/kg-d; UF = 100 Basis NOEL = 1.5 mg/kg/day, UF = 100, kidney, dog, oral (Diamond Shamrock Chemical, 1970a) Diamond Shamrock Chemical, 1970, Basis NOEL/LEL, MF = 1, kidney, dog, UF = 100 90-day oral study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 53,155,1990 Other Supporting Data Source Value Units Notes Is contaminant on list of CACART; Yes carcinogens? IARC; EPA; OEHHA; RAIS Is the contaminant on a list of CACART Yes reproductive toxins? Drinking Water Equivalent Level EPA HA 0.5 mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-26 ------- Chlorothalonil PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 4,547 15 Sites Sites 0.33% 0.007 0.71 0.05 0.41 0.71 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Toccalinoetal., 2010 California Drinking Water Monitoring Data STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application T ' R I I t fTRh ^ f W oxics eease nven ory ( ) ur ace a er Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 4,099 6 6 225 312 507 1,296 694 Amount Released 11,916,713 146 91,363 Amount Range 0 0 0 0 0 0 0 12 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Sites Sites Samples Samples Samples PWS Sites Number of States 48 1 7 Date 2006 0% 0% 0% 0% 0% 0% 0% 1.73% Units States States States 0 Date 1997 2010 2010 56 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0 1.93 47.1 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 1993-2007 1995-2007 Updated 201 3 Source OPP Value BF 2,392 3.05 2E-06 0.6 7 Drinking water monitoring Raw =inished Finished Water; Method 9060 (HPLC/MS) Ambient Water; Method 9060 (HPLC/MS) Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes length of time BF = Biodegrades fast (BIODEG) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-27 ------- Dichlorvos PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Dichlorvos 2444 62737 Attribute Scores Potency 6 Severity 3 Prevalence 1 Magnitude 1 Source HSDB Use Insecticide; veterinary medicine 3-Model Categorical Prediction NL Health Reference Level (HRL)1: 3.5 ug/L Health Reference Level (HRL)1 cancer: 0.1 ug/L HRL/Concentration Ratio(s) No data for calculating HRL ratio Status CCL 3: No CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Value 0.0005 0.0005 0.0005 0.0005 0.004 0.625 Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Source EPA IRIS OEHHA RAIS HE EPA OPP EPA I ARC Source NTP Value 0.01 0.41 0.29 Suggestive B2 2B Male Rat Some Evidence Units mg/L (mg/kg-d)"1 (mg/kg-d)"1 Female Rat Equivocal Evidence Date 2006 1993 1990 1997 1993 1974 Date 1988 2005 2006 1989 1991 Male Mouse Some Evidence Critical Effect Plasma and RBCcholinesterase nhibition (dog study) Cholinesterase inhibition Plasma and RBC ChE inhib tion; blood Neurol. Brain and Coverings - other degenerative changes, Kidney, Ureter, Bladder - urine volume increased, Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true Cholinesterase Notes UF = 100; Basis NOAEL = 0.05 mg/kg-day AMVAC Chemical Corporation, 1990, NOAEL, dog, UF=100; Basis NOAEL = 0.05 mg/kg-d AMVAC Chemical Corporation, 1990, NOAEL/LOAEL, dog, UF=100 UF = 100 90-day dog study; NYZZA3 Nippon Yakuzaish kai Zasshi. Journal of the Japan Pharmaceutical Association. (Nippon Yakuznishikai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1949- Volume(issue)/page/year26,739,1974 Notes Gl, pancreas, leukemia; NTP, 1986 Vol. 53 Female Mouse Clear Evidence Other Supporting Data Source Value Units Notes Is contaminant on list of EPA; Yes carcinogens? RAISHE; OEHHA; IARC; CACART Is the contaminant on a list of UMD Yes Teratogen list reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used i 1 For the CCL process HRLs were calculated by 2 Cancer classifications were only used for screei n attribute scoring. Blank fields indicate there were no data available. converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. ming. For potency scoring quantitative cancer risk data were used. Page A1-28 ------- Dichlorvos PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites Sites Sites 0,00% 0.00% ug/L ug/L ug/L ug/L 1992-2001 1999-2004 1999-2004 1999-2004 Surface water; National Aggregate. Size of dataset not reported. Ground water; National Aggregate. Size of dataset not reported. Supplemental Water Data California Department of Health Services Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Hopple etal., 2009 Hopple etal., 2009 Hopple etal., 2009 California Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 107 317 221 221 49 49 68 1,828 321 Amount Released 0 265 Amount Range No Reports 0 0 0 0 1 7 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Samples Samples Samples Samples Samples PWS Sites Sites Number of States 0 2 Date 2002 0% 0% 0% 0% 0% 0% 0% 0.05% 2.18% Units States States States 0.01 0.07 Date 1997 2010 2010 0.01 0.218 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.01 0.178 0.01 0.199 0.01 0.216 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1999 1999 2002-2005 2002-2005 2002-2005 1995-2007 2004-201 1 Updated 201 3 Source OPP Value <1-3.5 DF 40.2 1.47 5.75E-07 8,000 27 Drinking water monitoring Ambient Water; Method 9002 (GC/MS) Finished Water; Method 9002 (GC/MS) Ground water; Phase 1; Source water; Hopple et al., 2009 Ground water; Phase 2; Finished water; Hopple et al., 2009 Ground water; Phase 2; Source water; Hopple et al., 2009, Anthropogenic organic compounds in source water of selected community water systems that use groundwater, 2002-05: USGS Sci. Investigations Report 2009-5200, p. 74 Value Date Units Notes days DF = Degrades fast (HSDB) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-29 ------- Dicofol PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Dicofol 5106 115322 Source HSDB Use Insecticide Attribute Scores Potency 6 Severity 3 Prevalence 10 Magnitude 6 3-Model Categorical Prediction L? Health Reference Level (HRL)1: 2.8 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/SW Chronic EEC: 5.6 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0.0004 0.002 22.5 Value C 3 Male Rat Negative Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Negative Date 1998 1992 2001 Date 1998 1987 Male Mouse Positive Critical Effect Inhibition of adrenal corticotropic hormone 3X FQPA (dog study) became an uncertainty factor (E-mail from OPP; NOAEL - 0.12 mg/kg-day) Related to Chronic Data - death Notes UF = 300; Basis NOAEL = 0.12 mg/kg-day one year dog study; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year2,1342,2001 Notes Female Mouse Negative Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-30 ------- Dicofol PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services California Drinking Water Monitoring Data STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water T ' D I I t rTDh T t I oxics e ease nven ory ( ) o a Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 21 17 35 Amount Released 786,805 0 33 0 0 0 Units Itas/yr Ibs/yr Ibs/yr Amount Range Units Ibs/yr PWS PWS Sites Number of States 36 0 2 Date 2006 0% 0% 0% Units States States States Date 1997 2004 2004 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 1995-2007 Updated 201 3 Source OPP Value 180 BST 10,500 5.02 2.42E-07 0.8 4 Drinking water monitoring Value Date SW Chronic = 0.5 ug/L; GW Chronic = 0.069 ug/L Units days L/kg dimensionless L/kg atm-rrp/mol mg/L % Notes BST = Biodegrades sometimes/recalcitrant (PBT) Page A1-31 ------- Endosulfan PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Endosulfan 5104 1 1 5297 Attribute Scores Potency 5 Severity 6 Prevalence 10 Magnitude 7 Source HSDB Use Insecticide 3-Model Categorical Prediction L?-L Health Reference Level (HRL)1: 42 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NCHRL/SW Chronic EEC: 28 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP EPA OPP IRIS EPA HA ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA IRIS EPA OPP I ARC Source NTP Value 0,006 0.006 0.002 0.006 Value IN E Male Rat Inadequate Study Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Negative Date 2007 1994 2000 1998 Date 1994 2007 Male Mouse Inadequate Study Critical Effect Reduced body weight gain, enlarged kidneys, increased incidences of marked progressive glomerulonephrosis; bloodvessel aneurysms in males. Reduced body weight gain in males and females, increased incidence of marked progressive glomerulonephrosis and blood vessel aneurysms in males. hepatic; liver Notes Basis NOAEL = 0.6 mg/kg-d; UF = 100 (rat study) Hoechst, 1989a, Basis NOAEL = 0.7 mg/kg-d (female) and 0.6mg/kg-d (male); UF=100 (rat study) Hoechst, 1989c, Basis NOAEL = 0.18 mg/kg-d, dog, UF=100 Notes Female Mouse Negative Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of UMD Yes teratogen list reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used i 1 For the CCL process HRLs were calculated by 2 Cancer classifications were only used for scree n attribute scoring. Blank fields indicate there were no data available. converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. ;ning. For potency scoring quantitative cancer risk data were used. Page A1-32 ------- Endosulfan PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application T ' R I I t fTRh ^ f W eease nven ory Toxics Release Inventory (TRI) -Total 665 Amount Released 1,601,195 105 Units Itas/yr Ibs/yr Ibs/yr Sites Number of States 44 Production Chemical Update System/Inventory Update Reporting (CUS/IUR) Amount Range Units Ibs/yr Date 2006 15.79% Units States States States Date 1997 2010 2010 0.1 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.01 0.01 ug/L | Updated 201 3 Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water Source OPP Value 180 BST 22,000 3.83 6.51 E-05 0.45 4 Value Date SW Chronic- 1 5 ug/L- GW Chronic - 0 012 ug/L Units days L/kg dimensionless L/kg atm-nf/mol mg/L % Notes BST = Biodegrades sometimes/recalcitrant (PBT) Page A1-33 ------- Fluometuron PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Fluometuron 12839 21 641 72 Attribute Scores Potency 5 Severity 3 Prevalence 9 Magnitude 5 Source HSDB Use Herbicide 3-Model Categorical Prediction NL? Health Reference Level (HRL)1: 38.5 ug/L Health Reference Level (HRL)1 cancer: 1.94 ug/L HRL/Concentration Ratio(s) NC HRL/NAWQA AW 90%: 19.25 CAR HRL/NAWQA AW 90%: 0.97 CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA EPA OPP OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0.0055 0.013 0.01 0.013 100 Value 0.018 C 3 Male Rat Negative Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-1 (mg/kg-d)-1 (mg/kg-d)-1 Female Rat Negative Date 1987 1987 1987 Date 2005 1987 Male Mouse Equivocal Critical Effect Decreased body weight gain and discoloration in the spleen. No adverse effects. Endocrine - changes in spleen weight, Blood - changes in spleen, Nutritional and Gross Metabolic - weight loss or decreased weight gain Notes Female Mouse Negative Notes Basis NOAEL = 0.55 mg/kg-day; UF = 100 NCI, 1980, NOAEL 12.5 mg/kg-d, rat, UF=1000 90-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB80-217904 Other Supporting Data Source Value Units Notes Is contaminant on list of EPA Yes carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA 0.5 mg/L (DWEL) Note: Highlighted data indicate value was used i 1 For the CCL process HRLs were calculated by 2 Cancer classifications were only used for scree n attribute scoring. Blank fields indicate there were no data available. converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. ;ning. For potency scoring quantitative cancer risk data were used. Page A1-34 ------- Fluometuron PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 4,600 130 Sites Sites 2.83% 0.003 37.77 0.22 2 8.34 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data Pesticide Data Program (POP) Pesticide Data Program (POP) Toccalinoetal., 2010 California Drinking Water Monitoring Data STOrage and RETrieval (STORET) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 11 5 590 27 505 Number 225 312 Amount Released 5,313,290 0 0 2 2 6 0 8 Number of Detects 19 24 Units Ibs/yr Ibs/yr Ibs/yr Amount Range Units Ibs/yr Sites Sites Samples PWS Sites PWSs/ Sites/ Samples Samples Samples Number of States 15 0 0 Date 2006 18.2% 40% 1% 0% 1.58% Percent with Detects 8.4% 7.7% Units States States States 0.002 0.002 0.0044 0 Minimum Cone. (Detects) Date 1997 2010 2010 0.042 0.028 1.22 0 Maximum Cone. (Detects) 0.1 0.264 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.007 0.007 0.0139 0 Median Cone. (Detects) 0.007 0.007 0.699 0 75th Percentile (Detects 0.033 0.019 1.17 0 95th Percentile (Detects) 0.062 0.145 ug/L ug/L ug/L ug/L ug/L Cone. Units ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1993-2007 1995-2007 Updated 201 3 Date 1999 1999 Source OPP Value BST 363 2.42 1.8E-09 110 12 -inished Raw Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Notes Finished Water; Method 9060 (HPLC/MS) Ambient Water; Method 9060 (HPLC/MS) Value Date Units Notes length of time BST = Biodegrades sometimes/recalcitrant (BIODEG) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-35 ------- Linuron PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Linuron 6584 330552 Source HSDB Use Herbicide Attribute Scores Potency 5 Severity 3 Prevalence 1 Magnitude 1 3-Model Categorical Prediction NL Health Reference Level (HRL)1: 56 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NCHRL/NAWQA90%: 215 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA IRIS EPA OPP I ARC Source NTP Value 0,008 0.002 0.002 4.93 Value C C Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Date 1995 1986 1975 Date 1989 1995 Male Mouse Critical Effect Decreased RBC count, hematocrit & hemoglobin levels Abnormal blood pigment Abnormal blood pigment Blood - changes in serum compos tion (e.g. TP, bilirubin, cholesterol), Biochemica - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes Notes Basis NOAEL = 0.77 mg/kg-day; UF = 100. du Pont, 1962. du Pont, 1962; Bas s LEL 0.625 mg/kg-d, dog, UF=300. NOEL not established. du Pont, 1962; Bas s LEL 0.625 mg/kg-d, dog, UF=300. NOEL not established. 31 -week oral study n rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(7), 46, 1975 Notes Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of CACART Yes Developmental reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-36 ------- Linuron PCCL 4 Contaminant Information Sheet EPA-OGWDW OCCURRENCE DATA Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR 1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) 293 0 PWS PWS PWS PWS 0% ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 7,142 105 Sites Sites 1.47% 0.0005 1.4 0.03 0.26 0.74 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Toccalinoetal., 2010 California Drinking Water Monitoring Data Illinois Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total 142 13 7 323 312 228 225 512 42 1 753 592 Amount Released 516,133 0 1 0 2 1 1 0 0 0 1 0 0 0 15 Units Ibs/yr Ibs/yr Ibs/yr PWS Sites Sites Samples Samples Samples Samples Samples PWS PWS Sites Sites Number of States 35 0 1 Production Chemical Update System/Inventory Update Reporting (CUS/IUR) Amount Range No Reports Units Ibs/yr Date 2002 0% 15.4% 14.3% 0.3% 0% 0% 0% 0.2% 0% 0% 0% 2.53% Units States States States 0.0075 0.0042 0.0123 0 Date 1997 2010 2010 0.315 0.019 0.035 0.0123 3.5 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.161 0.011 0.0123 0 0.284 0.017 0.0123 1.3 0.312 0.019 0.0123 3.3 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 1999 1999 1993-2007 1995-2007 1998-2005 2004-201 1 Updated 201 3 Source OPP Value 60 BST 350 3.2 6.26E-09 75 11 Drinking water monitoring =inished Raw Ambient Water; Method 2001 (GC/MS) Ambient Water; Method 9060 (HPLC/MS) Finished Water; Method 2001 (GC/MS) Finished Water; Method 9060 (HPLC/MS) Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Units days L/kg dimensionless L/kg atm-rrp/mol mg/L % Date Notes BST = Biodegrades sometimes/recalcitrant (PBT) Page A1-37 ------- Malathion PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Malathion 5402 121755 Source HSDB Use Insecticide; veterinary medicine Attribute Scores Potency 4 Severity 3 Prevalence 9 Magnitude 3 3-Model Categorical Prediction NL Health Reference Level (HRL)1: 490 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/NAWQA 90%: 5,698 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0,07 0.02 0.02 0.02 0.02 0.3 0.34 Value Suggestive 3 Male Rat Negative Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-' Female Rat Negative Date 2006 1987 1992 1987 2003 1997 2001 Date 2006 Male Mouse Not Tested Critical Effect RBC cholinesterase inhibit on in pups Red blood cell cholinesterase inhibition RDBChE depression cholinesterase inhibition Blood - changes in serum compos tion (e.g. TP, bilirubin, cholesterol), Biochemica - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Notes Basis BMDL = 7.1 mg/kg-d; UF = 100 (rat study) Moellerand Rider, 1962, basis NOEL 0.23 mg/kg-d, human, UF=10 Moellerand Rider, 1962, basis NOEL/LEL, human, UF=10 Daly, 1996, basis NOAEL 2 mg/kg-d, rat, UF=100 56-day oral study in human; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 Volume(issue)/page/year 1,59,2001 Notes Female Mouse Not Tested Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of UMD Yes teratogen reproductive toxins? Drinking Water Equivalent Level EPA HA 0.8 mg/L Drinking Water Equivalent Level (DWEL) Maximum Acceptable Concentration CADW 0.19 mg/L Canadian Drinking Water Maximum Acceptable (MAC) Concentration Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-38 ------- Malathion PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) 7,117 344 Sites Sites 4.83% 0.0015 9,58 0.0137 0.0863 0.394 ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Toccalinoetal., 2010 California Drinking Water Monitoring Data USGS/California Groundwater Ambient Monitoring and Assessment (GAMA) Program STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy (NCFAP) - Application . /-rnl\ (T- Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 271 7 13 323 228 898 58 1,828 1,491 Amount Released 5,809,943 5 13,250 Amount Range 0 0 2 6 0 0 0 0 178 Units Ibs/yr Ibs/yr Ibs/yr Units Ibs/yr PWS Sites Sites Samples Samples Samples PWS Sites Sites Number of States 42 1 7 Date 2006 0% 0% 15.4% 1.9% 0% 0% 0% 0% 11.94% Units States States States 0.01 0 Date 1997 2010 2010 0.331 0.106 3.43 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0.171 0.048 0.299 0.186 0.328 1.2 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 1993-2007 1995-2007 2004-201 1 Updated 201 3 Source OPP Value 11 DF 30.5 2.36 4.89E-09 143 25 Drinking water monitoring Raw =inished Ambient Water; Method 2001 (GC/MS) Finished Water; Method 2001 (GC/MS) Ground water; Source Water; Toccalino et al., 2010, Quality of source water from public-supply wells in the United States, 1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206 Value Date Units Notes days DF = Degrades fast (HSDB) L/kg dimensionless L/kg atm-nf/mol mg/L % Page A1-39 ------- Phosmet PCCL 4 Contaminant Information Sheet EPA-OGWDW Contaminant: Substance Key: Contaminant ID (CASRN): Phosmet 9544 732116 Source HSDB Use Insecticide Attribute Scores Potency 6 Severity 3 Prevalence 1 Magnitude 1 3-Model Categorical Prediction NL Health Reference Level (HRL)1: 42 ug/L Health Reference Level (HRL)1 cancer: N/A HRL/Concentration Ratio(s) NC HRL/GWC EEC: 105 Status CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: No HEALTH EFFECTS DATA Non-Cancer Data Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Reference Dose (RfD) Minimal Risk Level Acceptable Daily Intake (ADI) Acceptable Daily Intake (ADI) Tolerable Daily Intake (TDI) No Observed Effect Level (NOEL) Lowest Observed Adverse Effect Level (LOAEL) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Lethal Dose 50 (LD50) Cancer Data Lifetime Cancer Risk (10"-4) Slope Factor (Oral) Slope Factor (Oral) Cancer Classification2 Cancer Classification2 Cancer Classification2 Source EPA OPP IRIS EPA HA RAIS HE ATSDR JMPR CEDI ADI ITER CTD JPN RTECS HSDB CTD JPN RTECS Source EPA OEHHA RAIS HE EPA OPP I ARC Source NTP Value 0,006 0.02 0.02 0.01 26 Value Suggestive Male Rat Units mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg-d mg/kg mg/kg mg/kg Units mg/L (mg/kg-d)-' (mg/kg-d)-1 Female Rat Date 2010 1986 1986 1998 1969 Date 2010 Male Mouse Critical Effect RBC cholinesterase inhibit on (rat study) Red. Body weight; liver cell vacuo zation; ChE inhibition Reduced bodywt; liver cell vacuolization; Cholinerase inhibition Behavioral - somnolence (general depressed activity), Behavioral - muscle contraction or spasticity, Lungs, Thorax, or Resp ration - dyspnea Notes Basis BlvlDL = 0.6 mg/kg-day. RfD is for general population. Stauffer Chemical 1967; Basis NOEL 2 mg/kg-d, male rat, UF=100 Stauffer Chemical 1967; Basis NOEL/LEL, ma e rat, UF=101 HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year 34(1 -3), 192, 1969 Notes Female Mouse Other Supporting Data Source Value Units Notes Is contaminant on list of carcinogens? Is the contaminant on a list of reproductive toxins? Drinking Water Equivalent Level EPA HA mg/L (DWEL) Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used. 2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used. Page A1-40 ------- Phosmet PCCL 4 Contaminant Information Sheet OCCURRENCE DATA EPA-OGWDW Number of PWSs/Sites/ Samples Number of Detects PWSs/ Sites/ Samples Percent with Detects Minimum Cone. (Detects) Maximum Cone. (Detects) Median Cone. (Detects) 90th Percentile (Detects) 99th Percentile (Detects) Cone. Units Date Notes Finished Water Data Unregulated Contaminant Monitoring Rule (UCMR1) Unregulated Contaminant Monitoring (UCM) Round 1 Unregulated Contaminant Monitoring (UCM) Round 2 National Inorganics and Radionuclide Survey (NIRS) PWS PWS PWS PWS ug/L ug/L ug/L ug/L 2001-2003 1988-1992 1993-1997 1984-1986 Ambient Water Data National Water-Quality Assessment Program (NAWQA) National Reconnaissance of Emerging Contaminants (NREC) Sites Sites ug/L ug/L 1992-2001 1999-2004 Supplemental Water Data California Department of Health Services Pesticide Data Program (POP) Pesticide Data Program (POP) Pesticide Pilot Monitoring Program (PMP) Pesticide Pilot Monitoring Program (PMP) Hopple etal., 2009 Hopple etal., 2009 Hopple etal., 2009 California Drinking Water Monitoring Data STOrage and RETrieval (STORET) Application/Release Data National Center for Food and Agricultural Policy Toxics Release Inventory (TRI) - Surface Water Toxics Release Inventory (TRI) -Total Production Chemical Update System/Inventory Update Reporting (CUS/IUR) 11 13 6 317 221 34 211 34 2 700 Amount Released 1,333,468 0 0 0 0 0 0 20 Units Ibs/yr Ibs/yr Ibs/yr Amount Range Units Ibs/yr PWS Sites Sites Samples Samples Samples Samples Samples PWS Sites Number of States 40 Date 2006 0% 0% 0% 0% 0% 0% 0% 0% 0% 2.86% Units States States States 0 Date 1997 2010 2010 0.222 Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available. 0 0.198 0.217 ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L ug/L Other Supporting Data Estimated Environmental Concentration (EEC) Environmental Fate Parameters Half Life Degradation Code Organic Carbon Partitioning Coefficient (Koc) Log Octanol-water Partitioning Coefficient (Kow) Distribution Coefficient (Kd) Henry's Law Coefficient Solubility in Water Modeled Percent in Water 2003-2009 2003-2009 1999 1999 2002-2005 2002-2005 2002-2005 1995-2007 Updated 201 3 Source OPP Value 38 BSA 42.9 2.78 8.39E-09 24.4 41 Drinking water monitoring rinished Raw Ambient Water; Method 9002 (GC/MS) Finished Water; Method 9002 (GC/MS) Ground water; Phase 2; Source water; Hopple etal., 2009, Anthropogenic organic compounds in source water of selected community water systems that use groundwater, 2002-05: USGS Sci. Investigations Report 2009-5200, p. 74 Ground water; Phase 1; Source water; Hopple et al., 2009 Ground water; Phase 2; Finished water; Hopple et al., 2009 Value SW Chronic = N/A GW Chronic = 0.4 ug/L Date Units days L/kg dimensionless L/kg atm-nf/mol mg/L % Notes BSA = Biodegrades slow with acclimation (PBT) Page A1-41 ------- EPA OGWDW Contaminant Information Sheets for Microbes Appendix 2: Microbial Contaminant Information Sheets Page A2 -1 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Adenovirus Scoring Data Scoring Summary1'2 Occurrence 3 Health Effects General population Sensitive subpopulation(s) [CD, C] 6 4 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease Score2 5 4 3 2 1 3 Data Element Scoring Data Reference3 Waterborne Disease Outbreaks Has caused multiple (2 or more) documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008 Has caused at least one documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008 Has caused documented WBDOs at any time in the U.S.? Has caused WBDOs in countries other than the U.S.? Has never caused WBDOs in any country, but has been epidemiologically associated with water related disease? No No No Yes Europe N/A CDC, 1991 -CDC, 2011 CDC, 1991 -CDC, 2011 Kukkula et al., 1997 Occurrence Detected in drinking water in the U.S.? Yes PCR in connection with an outbreak. O'Reilly et al., 2007 Fong et al., 2007 Page A2 - 2 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 2 1 7 6[G] 5 4[C, CD] 3 Data Element Detected in source water in the U.S.? Not detected in the U.S.? Scoring Data Yes 38% of surface water samples collected as part of the Information Collection Rule contained Adenovirus 40/41. N/A Reference3 USEPA, 2007 Health Effects Does the organism cause significant mortality (> 1/1,000 cases)? Does the organism cause pneumonia, meningitis, hepatitis, encephalitis, endocarditis, cancer, or other severe manifestations of illness necessitating long term hospitalization (> week)? Does the illness result in long term or permanent dysfunction or disability, i.e. sequelae? Does the illness require short term hospitalization (< week)? Does the illness require physician intervention? [G] A frequent cause of pneumonia among (unvaccinated) military recruits. Two deaths in previously-healthy adults. ARD is still a significant problem in military. Less common manifestations include fatal neonatal disease, meningoencephalitis and myocarditis. None reported [CD] Children with chronic disease required respiratory ventilation. [C] Young adults may contract acute respiratory disease. Physician office visits are indicated for ocular infections. Gray et al., 2001 Robinson in Murray, 2010 CDC, 1983 CDC, 1998 Robinson in Murray, 2010 Page A2 - 3 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 Data Element Scoring Data Reference3 2 [E, P] Is the illness self-limiting within 72 hours (without requiring medical intervention)? [E, P] Approximately 50% of cases are asymptomatic, symptomatic cases usually present as upper respiratory infections similar to the common cold. Robinson in Murray, 2010 Does the illness result in mild symptoms with minimal or no impact on daily activities? 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease. 2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final. August 2009 for a detailed description on how to calculate the total pathogen score. 3EPA based the WBDO scores on the CDC MMWR reports from 1991 - 2008 and then collected occurrence citations if there were no CDC WBDOs. References CDC, 1983. Adenovirus type 7 outbreak in a pediatric chronic-care facility - Pennsylvania. 1972. MMWR, 1983:32;258-60. CDC, 1998. Civilian Outbreak of Adenovirus Acute Respiratory Disease - South Dakota, 1997. MMWR 1998: 47(27);567-570. CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1989—1990. MMWR Surveillance Summaries, 40(SS-3); 1-21. CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1991—1992. MMWR Surveillance Summaries, 42(SS-5); 1-22. CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1993—1994. MMWR Surveillance Summaries, 45(SS-1); 1-33. CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1995—1996. MMWR Surveillance Summaries, 47(SS-5); 1-33. CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1997—1998. MMWR Surveillance Summaries, 49(SS-4); 1-35. Page A2 - 4 ------- EPA OGWDW Contaminant Information Sheets EPA 815-R-15-003 for Microbes CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1999—2000. MMWR Surveillance Summaries, 51(SS-8); 1-36. CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2001—2002. MMWR Surveillance Summaries, 53(SS08); 23-45. CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2003—2004. MMWR Surveillance Summaries, 55(SS12); 31-58. CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water and Water not Intended for Drinking — United States, 2005-2006. MMWR 57 (SS-9); 1- 72 (Table 4, p. 45; Table 5 p. 46). CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46). Fong, T., L. Mansfield, D. Wilson, D. Schwab, S Molloy and J Rose. 2007. Massive Microbiological Groundwater Contamination Associated with a Waterborne Outbreak in Lake Erie, South Bass Island, OH. Environmental Health Perspectives. Gray, G C, P R Goswami, M D Malasig, A W Hawksworth, D H Trump, M A Ryan and D P Schnurr. 2001. Adult Adenovirus Infections: Loss of Orphaned Vaccines Precipitates Military Respiratory Disease Epidemics. Clinical Infectious Diseases, 31: 663-70. Kukkula, M., Arstila P., Klossner M.L., Maunula L., Bonsdorff C.H., and P. Jaatinen. 1997. Waterborne outbreak of viral gastroenteritis. Scandinavian Journal of Infectious Disease, 29(4): 415-8. O'Reilly, C.E., A.B. Bowen, E.P. Nytzia, J.P. Sarisky, C.A. Shepherd, M.D. Miller, B.C. Hubbard, M. Herring, S.D. Buchanan, C.C. Fitzgerald, V. Hill, MJ. Arrowood, L.X. Xiao, R.M. Hoekstra, E.D. Mintz, M.F. Lynch, and the Outbreak Working Group. 2007. A Waterborne Outbreak of Gastroenteritis with Multiple Etiologies among Resort Island Visitors and Residents: Ohio, 2004. Clinical Infectious Diseases, 44:506-512. http://www.journals.uchicago.edu/CID/journal/issues/v44n4/40825/40825.text.html - fnl#fnlhttp://wwwjournals.uchicago.edu/CID/journal/issues/v44n4/40825/40825.text.html - fn2#fn2 Robinson, C. and M. Echavarria. 2010. Adenoviruses. In Murray, P. R., E. J. Baron, J. H. Jorgensen, M.L. Landry, and M. A. Pfaller (ed.) The Manual of Clinical Microbiology, 10th. edition, American Society for Microbiology, Washington, DC. Vol. 2: p. 1600. USEPA. 2007. Adenovirus Health and Criteria Document (Draft). Page A2 - 5 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Naegleria fowleri Scoring Data Scoring Summary1'2 Waterborne Disease Outbreak 4 Health Effects General population Sensitive subpopulation(s) [C, P, E, CD] 7 7 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease Score2 5 4 3 2 1 Data Element Scoring Data Reference3 Waterborne Disease Outbreaks Has caused multiple (2 or more) documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008? Has caused at least one documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008? Has caused documented WBDOs at any time in the U.S.? Has caused WBDOs in countries other than the U.S.? Has never caused WBDOs in any country, but has been epidemiologically associated with water related disease? No Yes 1 Community N/A N/A N/A CDC, 1991 -CDC, 2011 CDC, 2004 Page A2 - 6 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 3 2 1 7[G,C,P, E,CD] 6 5 4 O 2 Data Element Scoring Data Reference3 Occurrence Detected in drinking water in the U.S.? Detected in source water in the U.S.? Not detected in the U.S.? Yes Arizona storage - Sampled pre-treatment multiple-well study in Arizona. Yes N/A Gerba et al., 2007 Marciano-Cabral et al., 2003 Schuster and Visvesvara, 2004 Health Effects Does the organism cause significant mortality (> 1/1,000 cases)? Does the organism cause pneumonia, meningitis, hepatitis, encephalitis, endocarditis, cancer, or other severe manifestations of illness necessitating long term hospitalization (> week)? Does the illness result in long term or permanent dysfunction or disability, i.e. sequelae? Does the illness require short term hospitalization (< week)? Does the illness require physician intervention? Is the illness self-limiting within 72 hours (without requiring medical intervention)? [All populations] Recovery from primary amoebic meningoencephalitis is rare. Acute fulminating disease. Only a few patients have survived. No All cases are hospitalized for diagnosis and treatment. Heymann, 2005 Visvesvara in Murray, 2010 Visvesvara in Murray, 2010 Page A2 - 7 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 1 Data Element Does the illness result in mild symptoms with minimal or no impact on daily activities? Scoring Data Reference3 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease. 2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final. August 2009 for a detailed description on how to calculate the total pathogen score. 3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected occurrence citations if there were no CDC WBDOs. References CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1989—1990. MMWR Surveillance Summaries, 40(SS-3); 1-21. CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1991—1992. MMWR Surveillance Summaries, 42(SS-5); 1-22. CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1993—1994. MMWR Surveillance Summaries, 45(SS-1); 1-33. CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1995—1996. MMWR Surveillance Summaries, 47(SS-5); 1-33. CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1997—1998. MMWR Surveillance Summaries, 49(SS-4); 1-35. CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1999—2000. MMWR Surveillance Summaries, 51(SS-8); 1-36. CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2001—2002. MMWR Surveillance Summaries, 53(SS08); 23-45. CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2003— 2004. MMWR Surveillance Summaries, 55(SS12); 31-58. CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water and Water not Intended for Drinking — United States, 2005-2006. MMWR 57 (SS-9); 1- 72 (Table 4, p. 45; Table 5 p. 46). Page A2 - 8 ------- EPA OGWDW Contaminant Information Sheets EPA 815-R-15-003 for Microbes CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46). Gerba, C., B. Blair, P. Sarkar, and K. Bright. 2007. Occurrence and Control of Naegleria fowleri in Well Water and Chlorine Resistance. Proceedings, Water Quality Technology Conference, American Water Works Association, November 5-8, 2007. Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual, 18th ed. American Public Health Association, Washington, DC. pp. 417-419. Marciano-Cabral, F., R. MacLean, A. Mensah, and L. LaPat-Polasko. 2003. Identification of Naegleria fowleri in domestic water source by nested PCR. Appl. Environ. Microbiol. 69 (10): 5864-5869. Schuster, F.L. and G.S. Visvesvara. 2004. Free-living amoebae as opportunistic and non- opportunistic pathogens of humans and animals. Int. J. Parasitol. 34: 1001-1027. Visvesvara, G. 2007. Pathogenic and Opportunistic Free-Living Amebae. In Murray, P. R., E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H Yolken (ed.) The Manual of Clinical Microbiology, 10th edition, American Society for Microbiology, Washington, DC Vol. 2; pp. 3129. Page A2 - 9 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Toxoplasma gondii Scoring Data Scoring Summary1'2 Waterborne Disease Outbreak 2 Health Effects General population Sensitive subpopulation(s) [P] 2 7 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease Score2 5 4 3 2 1 Data Element Scoring Data Reference3 Waterborne Disease Outbreaks Has caused multiple (2 or more) documented WBDOsintheU.S. as reported by CDC surveillance between 1990 and 2008? Has caused at least one documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008? Has caused documented WBDOs at any time in the U.S.? Has caused WBDOs in countries other than the U.S.? Has never caused WBDOs in any country, but has been epi demi ol ogi cally associated with water related disease? No No No Yes Canada and Brazil. N/A CDC, 1991 -CDC, 2011 CDC, 1991 -CDC, 2011 Bowie et al., 1997 de Moura, 2006 Page A2 - 10 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 3 2 1 7[P] 6 5 Data Element Scoring Data Reference3 Occurrence Detected in drinking water in the U.S.? Detected in source water in the U.S.? Not detected in the U.S.? No No Yes Groundwater in Poland and Canada. Sroka et al., 2006 Isaac-Renton et al., 1998 Health Effects Does the organism cause significant mortality (> 1/1,000 cases)? Does the organism cause pneumonia, meningitis, hepatitis, encephalitis, endocarditis, cancer, or other severe manifestations of illness necessitating long term hospitalization (> week)? Does the illness result in long term or permanent dysfunction or disability, i.e. sequelae? [P] Congenital infection of neonates severe. Infection during early pregnancy may lead to fetal infection with death of the fetus or other severe manifestations. Later in pregnancy, maternal infection results in mild or subclinical fetal disease. Immunocompromi sed hosts may experience CNS, pneumonitis, and myocarditis. Wilson in Murray, 2010 Heymann, 2005 Wilson in Murray, 2010 PageA2- 11 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 4 3 2 [G, C, E, CD] 1 Data Element Does the illness require short term hospitalization (< week)? Does the illness require physician intervention? Is the illness self- limiting within 72 hours (without requiring medical intervention)? Does the illness result in mild symptoms with minimal or no impact on daily activities? Scoring Data Treatment is indicated only for pregnant women, infants and immunocompromi sed hosts. [G, C, E, CD] Infection is generally asymptomatic; however 10 -20% of patients with acute infection may develop cervical lymphadenopathy and/or flu-like symptoms. Reference3 Wilson in Murray, 2010 Wilson in Murray, 2010 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease. 2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final. August 2009 for a detailed description on how to calculate the total pathogen score. 3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected occurrence citations if there were no CDC WBDOs. References Bowie, W. R., S. A. King, D. H. Werker, J. L. Isaac-Renton, A. Bell, S. B. Eng, and S. A. Marion. 1997. Outbreak of toxoplasmosis associated with municipal drinking water. Lancet 350: 173-177. CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1989—1990. MMWR Surveillance Summaries, 40(SS-3); 1-21. CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — Page A2 - 12 ------- EPA OGWDW Contaminant Information Sheets EPA 815-R-15-003 for Microbes United States, 1991—1992. MMWR Surveillance Summaries, 42(SS-5); 1-22. CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1993—1994. MMWR Surveillance Summaries, 45(SS-1); 1-33. CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1995—1996. MMWR Surveillance Summaries, 47(SS-5); 1-33. CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1997—1998. MMWR Surveillance Summaries, 49(SS-4); 1-35. CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1999—2000. MMWR Surveillance Summaries, 51(SS-8); 1-36. CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2001— 2002. MMWR Surveillance Summaries, 53(SS08); 23-45. CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2003— 2004. MMWR Surveillance Summaries, 55(SS12); 31-58. CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water and Water not Intended for Drinking — United States, 2005-2006. MMWR 57 (SS-9); 1- 72 (Table 4, p. 45; Table 5 p. 46). CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46). Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual, 18th ed. American Public Health Association, Washington, DC. Isaac-Renton, J, W.R. Bowie, A. King, G.S. Irwin, C.S. Ong, C.P. Fung, M.O. Shokeir and J.P. Dubey. 1998. Detection of Toxoplasma gondii Oocysts in Drinking Water. Appl. Environ. Microbiol. 64(6): 2278-2280. de Moura L., L.M. Bahia-Oliveira, M.Y. Wada, J.L. Jones, S.H. Tuboi, E.H. Carmo, W.M. Ramalho, N.J. Camargo, R. Trevisan, R.M. Graca, AJ. da Silva, I. Moura, J.P. Dubey, and D.O. Garrett. 2006. Waterborne toxoplasmosis, Brazil, from field to gene. Emerging Infectious Diseases, 12(2): 326-9. Sroka J., A. Wojcik-Fatla, J. Dutkiewicz. 2006. Occurrence of Toxoplasma Gondii in Water from Wells Located on Farms. Ann Agric Environm Med. 13: 169-175. Jones, J., J. McAuley and K. Singh. 2010. Toxoplasma. In Murray, P. R., E. J. Baron, J. H. Jorgensen, M.L. Landry, and M. A. Pfaller (ed.) The Manual of Clinical Microbiology, 10th. edition, American Society for Microbiology, Washington, DC. Vol. 2: p. 2127. Page A2 - 13 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Vibrio cholerae Scoring Data Scoring Summary1'2 Waterborne Disease Outbreak 4 Health Effects General population Sensitive subpopulation(s) [C, E, P, CD] 3 3 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease Score2 5 4 3 2 1 3 Data Element Scoring Data Reference3 Waterborne Disease Outbreaks Has caused multiple (2 or more) documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008? Has caused at least one documented WBDOs in the U.S. as reported by CDC surveillance between 1990 and 2008? Has caused documented WBDOs at any time in the U.S.? Has caused WBDOs in countries other than the U.S.? Has never caused WBDOs in any country, but has been epidemiologically associated with water related disease? No 1 Community N/A N/A N/A CDC, 1991 -CDC, 2011 CDC, 1996 Occurrence Detected in drinking water in the U.S.? Yes (outbreak data) CDC, 1996 Page A2 - 14 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 2 1 7 6 5 Data Element Detected in source water in the U.S.? Not detected in the U.S.? Scoring Data Yes N/A Reference3 Rhodes et al., 1986 Kaperetal., 1982 Health Effects Does the organism cause significant mortality (> 1/1,000 cases)? Does the organism cause pneumonia, meningitis, hepatitis, encephalitis, endocarditis, cancer, or other severe manifestations of illness necessitating long term hospitalization (> week)? Does the illness result in long term or permanent dysfunction or disability, i.e. sequelae? V. cholerae Non-Ol : third most commonly isolated in U.S. - Septicemia case fatality rate from 24-65%. V. cholerae Ol: Extremely rare cases causes severe extraintestinal infection. If untreated, V. cholerae Ol infection causes severe dehydration which leads to hypovolemic shock, acidosis, circulatory collapse, and death. Unlike Ol strains, non-Ol isolates are commonly associated with extrainstestinal infections such as septicemia. Abbott in Murray, 2010 Abbott in Murray, 2010 Page A2 - 15 ------- EPA OGWDW Contaminant Information Sheets for Microbes EPA 815-R-15-003 Score2 4 3 [G, C, P, E, CD] 2 1 Data Element Does the illness require short term hospitalization (< week)? Does the illness require physician intervention? Is the illness self-limiting within 72 hours (without requiring medical intervention)? Does the illness result in mild symptoms with minimal or no impact on daily activities? Scoring Data In severely dehydrated cases (cholera gravis), death may occur within a few hours, and the case- fatality rate may exceed 50%. With proper and timely rehydration, this can be less than 1%. [All populations] In most cases infection is asymptomatic or causes self-limiting diarrhea. Treatment consists of fluid replacement by oral rehydration therapy and/or intravenous fluids. Reference3 Heymann, 2005 Abbott in Murray, 2010 1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease. 2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final. August 2009 for a detailed description on how to calculate the total pathogen score. 3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected occurrence citations if there were no CDC WBDOs. References Abbott, S. L., J. M. Janda, and J. J. Farmer. 2010. Vibrio and Related Organisms. In Murray, P. R., E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H Yolken (ed.) The Manual of Clinical Microbiology, 8th. edition, American Society for Microbiology, Washington, DC. Vol. 1: pp. 666. CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — Page A2 - 16 ------- EPA OGWDW Contaminant Information Sheets EPA 815-R-15-003 for Microbes United States, 1989—1990. MMWR Surveillance Summaries, 40(SS-3); 1-21. CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1991—1992. MMWR Surveillance Summaries, 42(SS-5); 1-22. CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1993—1994. MMWR Surveillance Summaries, 45(SS-1); 1-33. CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1995—1996. MMWR Surveillance Summaries, 47(SS-5); 1-33. CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1997—1998. MMWR Surveillance Summaries, 49(SS-4); 1-35. CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 1999—2000. MMWR Surveillance Summaries, 51(SS-8); 1-36. CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2001—2002. MMWR Surveillance Summaries, 53(SS08); 23-45. CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water — United States, 2003—2004. MMWR Surveillance Summaries, 55(SS12); 31-58. CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water and Water not Intended for Drinking — United States, 2005-2006. MMWR 57 (SS-9); 1- 72 (Table 4, p. 45; Table 5 p. 46). CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46). Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual, 18th ed. American Public Health Association, Washington, DC. pp. 113-127. Kaper, J. B., H. B. Bradford, N. C. Roberts, and S. Falkow. 1982. Molecular epidemiology of Vibrio cholerae in the U.S. Gulf Coast. J. Clin. Microbiol. 16(1): 129-134. Rhodes, J.B., H.L. Smith Jr., and I.E. Ogg. 1986. Isolation of Non-Ol Vibrio cholerae Serovars from Surface Waters in Western Colorado. Appl. Environ. Microbiol. 51(6): 1216-1219. Page A2 - 17 ------- |