r   t       t
united states        Contaminant
Environmental Protection
Agency           Information Sheets
               (CISs) for the Draft
               Fourth Preliminary
               Contaminant
               Candidate List
               (PCCL 4) Nominated
               Contaminants

-------
Office of Water (4607M)
EPA 815-R-15-003
January 2015

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                          Draft PCCL 4 Nominated Contaminants

                                    Contents

  1.0     Introduction	1
  2.0     Summary of the Chemicals Classification Process from the PCCL to CCL 	3
  3.0     CCL 4 Chemicals CISs Explanation	5
  4.0     Summary of the Microbes  Classification Process from the PCCL to CCL and
          CISs Explanation	9
  5.0     References	10

  Appendix 1.      Chemical Contaminant Information Sheets                     Al-1
  Appendix 2.      Microbial Contaminant Information Sheets                    A2-1
                                  Page i of iv

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the            EPA 815-R-15-003
                              Draft PCCL 4 Nominated Contaminants
                                      Page ii of iv

-------
EPA-OGWDW
                       Contaminant Information Sheets (CISs) for the
                          Draft PCCL 4 Nominated Contaminants
EPA 815-R-15-003
CASRN
CCL
CCL 3
CCL 4
CIS
DWEL
EEC
EPA
HA
FR
HRL
IARC
IRIS
L
L?
Ibs
LOAEL
MCL
MCLG
MMWR
NL
NL?
NOAEL
NTP
OEHHA
OPP
PCCL
PCCL 4
PWS
RfD
SRS
SDWA
WBDO
WHO
                        Abbreviations and Acronyms

                Chemical Abstract Services Registry Number
                Contaminant Candidate List
                EPA's Third Contaminant Candidate List
                EPA' s Fourth Contaminant Candidate List
                Contaminant Information Sheet
                Drinking Water Equivalent Level
                Estimated Environmental Concentration
                United States Environmental Protection Agency
                Health Advisory
                Federal Register
                Health Reference Level
                International Agency for Research on Cancer
                Integrated Risk Information System
                List
                List?
                Lethal dose 50; an estimate of a single dose that is expected to cause the death
                of 50 percent of the exposed animals; it is derived from experimental data.
                Pounds
                Lowest Observed Adverse Effect Level
                Maximum Contaminant Level
                Maximum Contaminant Level Goal
                Morbidity and Mortality Weekly Report
                Not List
                Not List?
                No Observed Adverse Effect Level
                National  Toxicology Program
                Office of Environmental Health Hazard Assessment (California)
                Office of Pesticide Programs
                Preliminary-CCL
                EPA' s Fourth Preliminary-CCL
                Public Water System
                Reference Dose
                Substance Registry System/Substance Registry Services
                Safe Drinking Water Act
                Waterborne Disease Outbreak
                World Health Organization
                                  Page ill of iv

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the            EPA 815-R-15-003
                              Draft PCCL 4 Nominated Contaminants
                                      Page iv of iv

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                            Draft PCCL 4 Nominated Contaminants
1.0    Introduction

Section 1412(b)(l) of the Safe Drinking Water Act (SOWA), as amended in 1996, requires EPA
to publish the Contaminant Candidate List (CCL) every five years. The SDWA specifies that the
list must include contaminants that are not subject to any proposed or promulgated National
Primary Drinking Water Regulations (NPDWRs),  are known or anticipated to occur in public
water systems (PWSs) and may require regulation under the SDWA. EPA uses this list of
unregulated contaminants to help the agency identify priority contaminants for regulatory
decision making and to prioritize research and data collection efforts. SDWA also requires the
agency to consult with the scientific community, including the Science Advisory Board, and
provide notice and opportunity for public comment prior to the publication  of the Final CCL. In
addition,  SDWA directs the agency to consider the health effects and occurrence information for
unregulated contaminants to identify those contaminants that present the greatest public health
concern related to exposure from drinking water.

EPA published the third CCL (CCL 3), which listed 116 contaminants  on October 8, 2009 (74
FR 51850 (USEPA, 2009a)). In developing the CCL 3, EPA implemented a multi-step process to
select contaminants for the final CCL 3, which included the following key steps:

   (1) The identification of a broad universe of potential drinking water contaminants (CCL 3
      Universe);
   (2) Screening the CCL 3 Universe to a Preliminary CCL (PCCL) using  screening criteria
      based on the potential to occur in PWSs and the potential for public health concern;
   (3) Evaluation of the PCCL contaminants based on a more detailed review of the occurrence
      and health effects data using a scoring and classification system  to identify a final list of
      116 CCL 3 contaminants; and
   (4) Incorporating public input and expert review in the CCL 3 process.

Steps 1, 2 and 3 in the process are described in detail in the CCL 3 support documents:

      Final CCL 3 Chemicals: Identifying the  Universe (USEPA, 2009b);
      Final CCL 3 Chemicals: Screening to a PCCL (USEPA, 2009c);
      Final Contaminant Candidate List 3 Chemicals: Classification  of the PCCL to the CCL
       (USEPA, 2009d);
      Final CCL 3 Microbes: Identifying the Universe (USEPA, 2009e);
      Final CCL 3 Microbes: Screening to the PCCL (USEPA, 2009f);  and
      Final CCL 3 Microbes: PCCL to CCL Process (USEPA, 2009g).

These documents can be found on the EPA web site at: http://www2.epa.gov/ccl/contaminant-
candidate-list-3-ccl-3 or at http://www.regulations.gov (docket ID: EPA-HQ-OW-2007-1189).

After a Final CCL is published, SDWA section  1412(b)(l)(B)(ii) as amended in 1996, requires
EPA at five year intervals to make determinations  of whether to regulate or not to regulate no
fewer than five contaminants from the CCL in a process called regulatory determinations. This is
                                   Page 1 of 11

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the            EPA 815-R-15-003
                             Draft PCCL 4 Nominated Contaminants

a separate process from the listing of contaminants on the CCL. The 1996 SDWA Amendments
specify three criteria to determine whether a contaminant may require regulation:
      the contaminant may have an adverse effect on the health of persons;
      the contaminant is known to occur or there is a substantial likelihood that the contaminant
       will occur in PWSs with a frequency and at levels of public health concern; and
      in the sole judgment of the Administrator, regulation of such contaminant presents a
       meaningful opportunity for health risk reduction for persons served by PWSs.

If EPA determines that these three statutory criteria are met and makes a final determination to
regulate a contaminant, the agency has 24 months to publish a proposed Maximum Contaminant
Level Goal1 (MCLG) and NPDWR2. After the proposal, the agency has 18 months to publish
and promulgate a final MCLG and NPDWR (SDWA section  1412(b)(l)(E))3.

On February 11, 2011, as a separate action, the agency issued a positive regulatory determination
for perchlorate, a chemical listed in CCL 1, CCL 2 and CCL 3 (76 FR 7762 (USEPA, 2011)).
Recently, EPA has published preliminary regulatory determinations for five unregulated
contaminants on the CCL 3 (79 FR 62716 (USEPA, 2014a)).  The five contaminants include:
dimethoate;  1,3-dinitrobenzene; strontium; terbufos and terbufos sulfone. The agency is making
preliminary determinations to regulate one contaminant (strontium) and to not regulate four
contaminants (dimethoate; 1,3-dinitrobenzene; terbufos; and terbufos sulfone). Therefore, the
agency is removing perchlorate and these five contaminants from the Draft Fourth CCL (CCL 4),
pending the result of the final regulatory determinations for CCL 3.

EPA conducted an abbreviated evaluation and selection process for the  CCL 4. This abbreviated
CCL 4 process includes a three pronged approach: (1) carrying forward CCL 3 contaminants
(minus those with regulatory determinations), (2) seeking and evaluating nominations from the
public for additional contaminants to consider and (3) evaluating any new data for those
contaminants with  previous negative regulatory determinations from CCL 1 or CCL 2 for
potential inclusion on the CCL 4.

As part of the process to develop the CCL 4, EPA published a Federal Register notice (77 FR
27057 (USEPA, 2012)) requesting that the public submit nominations for chemical and
microbial contaminants to be considered for inclusion on the CCL 4. EPA also requested
supporting information that has been made available since the development of the CCL 3 or
existing information that was not considered in the development of the CCL 3, which shows that
the nominated contaminant may have an adverse health  effect on people and occurs or is likely to
1 The MCLG is the "maximum level of a contaminant in drinking water at which no known or anticipated adverse
effect on the health of persons would occur, and which allows an adequate margin of safety. Maximum contaminant
level goals are non-enforceable health goals." (40 C.F.R. 141.2; 42 U.S.C. 300g-l)
2 An NPDWR is a legally enforceable standard that applies to public water systems. An NPDWR sets a legal limit
(called a maximum contaminant level or MCL) or specifies a certain treatment technique (TT) for public water
systems for a specific contaminant or group of contaminants. The MCL is the highest level of a contaminant that is
allowed in drinking water and is set as close to the MCLG as feasible using the best available treatment technology
and analytical methods and taking cost into consideration.
3  The statute authorizes a nine month extension of this promulgation date.
                                    Page 2 of 11

-------
EPA-OGWDW             Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                           Draft PCCL 4 Nominated Contaminants

occur in public water systems. EPA reviewed the nominations and supporting information
provided by nominators to determine if any new data were provided that had not been previously
evaluated for CCL 3. The agency also collected additional data for the nominated contaminants,
when it was available, from both CCL 3 data sources that had been updated and from new data
sources that were not available at the time of CCL 3. A complete list of references provided by
nominators can be found in the support document Summary of Nominations for the Fourth CCL
(USEPA, 2015a).  A more detailed description of the CCL data sources collected by EPA may be
found in the support document Data Sources for the CCL 4 (USEPA, 2015b). EPA evaluated the
nominated contaminants utilizing the best available health effects and occurrence data and the
same process for screening and scoring contaminants that was used for CCL 3.

A summary of the process and data used to screen the contaminants nominated for CCL 4 from
the CCL 4 Universe to the PCCL 4 is included in the Screening Document for the Draft PCCL 4
Nominated Contaminants (USEPA, 2015c). This document summarizes the process used to
select contaminants from the PCCL for the CCL. This  document also presents the Contaminant
Information Sheets (CISs) for the nominated contaminants qualified for inclusion on the PCCL
4. The purpose of the CISs is to summarize the data used to evaluate the nominated contaminants
and to select contaminants for the Draft CCL 4.

For CCL 3, EPA published CISs for the 561 chemicals (USEPA, 2009h) and the 29 microbial
contaminants (USEPA, 2009g) on the PCCL 3 (these documents include the CISs for the 116
contaminants on the Final CCL 3 as well). In addition, Appendix E of the Protocol for the
Regulatory Determinations 3 Including Appendices A-F (USEPA, 2014b) includes a summary
of updated health and  occurrence data used to evaluate 35 CCL 3 contaminants in the regulatory
determinations process. This document presents 20 chemical CISs for the nominated chemicals
listed on the PCCL 4 (including CISs for the seven nominated chemicals that made the  Draft
CCL 4) and four microbial CISs  for the nominated microbes that are listed on the PCCL 4
(including CISs for the two nominated microbes that made the Draft CCL 4).
2.0    Summary of the Chemicals Classification Process from the
       PCCL to CCL

This section briefly summarizes the process developed under CCL 3 to evaluate contaminants
from the PCCL to assess if they should move forward to the CCL. EPA used this same process to
evaluate the nominated contaminants for listing on the Draft CCL 4. A detailed explanation of
this step in the process is provided in the Final Contaminant Candidate List 3 Chemicals:
Classification of the PCCL to CCL (USEPA, 2009d) and its appendices.

To identify  chemicals from the PCCL to include on the CCL, EPA used classification models
and a scoring system as tools. The classification models were used to process complex data in a
consistent and reproducible manner. An overarching premise in using classification models to
prioritize contaminants is that different contaminants can be compared on the basis of similar
attributes. The attributes are properties used to categorize contaminants for their potential to
occur in drinking water and for their potential to cause adverse health effects. Four attributes
were selected including two attributes describing health effects (Potency and Severity) and two
                                  Page 3 of 11

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                            Draft PCCL 4 Nominated Contaminants

attributes describing occurrence (Prevalence and Magnitude); these are discussed in more detail
in Section 3.0 of this document. Scoring protocols were developed for each of the four attributes
and these scores were used as input for the classification models. The scores for each attribute
increase with increasing potential to cause adverse health effects or potential to occur in drinking
water (e.g., a score of 10 indicates greater concern for adverse health effects or greater potential
to occur in drinking water, whereas a score of 1 indicates lesser concern). If a chemical had more
than one data element available for scoring, EPA used a hierarchy to establish which data
element should be used in scoring the potency attribute, the prevalence attribute and the
magnitude attribute. For the potency and severity attributes, if data were available for both the
cancer and noncancer endpoints, the higher of the cancer or noncancer potency scores was
selected to score the potency and the critical effect associated with the data used to score the
potency was used to score the severity. The attribute scoring protocols and data hierarchies are
discussed in more detail in the Final Contaminant Candidate List 3 Chemicals: Classification of
the PCCL to CCL (USEPA, 2009d) (see Appendix A for the  Attribute Scoring Protocols).

The classification models were calibrated using a training data set so that they mimicked an
expert panel's decisions to list or not list a contaminant on the CCL. The training data set
consisted of 202 sets of attribute scores for contaminants and the consensus category (list/not list
decisions) made by a team of EPA subject matter experts based on evaluating the data and the
attribute scores for those contaminants. The classification models developed a relationship
between the contaminant attribute scores (input variables) and the classification of the
contaminants into list and not list categories (output). The list and not list decisions were placed
into four primary categories: List (L), List? (L?), Not List? (NL?) or Not List (NL). The L? and
NL? categories were developed because the expert panel recognized that clear decisions on
listing contaminants could be made easily for some contaminants, but there was some
uncertainty associated with the decision for other contaminants. The L? category signifies that
the decision is leaning towards listing with some uncertainty, and NL? signifies that the decision
is leading towards not listing, but with some uncertainty. EPA used three classification models
and each model produced a  prediction for each PCCL contaminant. EPA used an additive
process to combine the  results of all three models. If all three models were in 100% agreement
on the categorical prediction, one of the four primary categorical predictions (L, L?, NL? or NL)
was assigned to that contaminant. If all three models did not  agree, then the contaminant was
assigned to a category in between the four primary categorical predictions. None of the models
categorized a contaminant more than one category higher or lower than the other models (i.e., no
contaminants were categorized by an "L" by one model and by an "NL?" by another model).
There are three "in between" categories including: L?-L, NL?-L? or NL-NL?. An example of a
contaminant that would be placed in an "in between" category is if one model placed the
contaminant into the "L" category and the other two models placed it into the "L?" category,
then it would be placed in the "L?-L" category.

As part of the last stage in the CCL 3 classification process, the model output was reviewed by
internal EPA experts and based upon issues identified by the reviewers, several post-model
refinements were added by EPA to the CCL 3 process. One important refinement that was added
to the process was that for contaminants with water data, EPA calculated the ratio between the
health reference level (HRL) and the 90*  percentile concentration level in water. If a 90*
percentile (of detections) concentration level was not available, the agency used the maximum or
                                    Page 4 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                           Draft PCCL 4 Nominated Contaminants

next highest percentile reported value. This HRL to concentration ratio was calculated for all
contaminants with water data and serves as a benchmark that suggests a greater concern if the
ratio is low (concentration close to the HRL) and a lesser concern when the ratio is high
(concentration well below the HRL) . If the ratio was less than 10, the contaminant was typically
selected for listing on the CCL 3. If the ratio was greater than 10, the contaminant was typically
not listed on the CCL and remained on the PCCL. For contaminants that had limited finished
water data, but more robust ambient water monitoring data, the ambient water concentration was
used to develop the ratio. If no measured water data were available EPA used modeled water
data for pesticides (Estimated Environmental Concentrations (EECs) developed by EPA's Office
of Pesticide Programs (OPP)), when available, to calculate the HRL to concentration ratios.

For contaminants with no water data (either measured or modeled) HRL to concentration ratios
could not be calculated.  For these contaminants (e.g., contaminants that only had release data for
occurrence), if the three-model categorical prediction was L, L?-L or L?, the contaminant was
typically listed on the CCL.

Another important post-model refinement included in the CCL 3 process considered the nature
of the best available data. Some chemicals on the PCCL were represented by only an LDso value
for health effects data and/or only production volume data for occurrence.  These data are not
typically sufficient for a contaminant to be included on the CCL. In such cases, the chemical was
not included on the CCL and remained on the PCCL.
3.0    CCL 4 Chemical CISs Explanation

This section presents a walk-through of the CISs with a brief explanatory discussion of the data
elements on the CIS and how they are used in the CCL process. The CIS for each contaminant is
a concise, two-page profile with the first page including the attribute scores, three model
categorical predictions, HRL/concentration ratios, use information, status of the contaminant in
the CCL process and health effects data. The second page includes occurrence data. (The
derivation and use of these data are explained in detail in Final Contaminant Candidate List 3
Chemicals: Classification of the PCCL to CCL (USEPA, 2009d).) For the chemical CISs for the
nominated contaminants that made the PCCL 4, please see Appendix A.

General and Summary Information

The top section of the first page of each chemical CIS contains seven sets of information that
includes contaminant identifiers, use and how the chemical was scored and ranked in the CCL
process. From left to right, the upper rows include:

   1)  Contaminant Identification - the contaminant name, a unique CCL-specific
       identification number referred to as a Substance Key (many of which were obtained from
       EPA's Substance Registry System, now known as Substance Registry Services (SRS);
       others were assigned during the CCL process if a  contaminant was not listed in SRS), and
       the contaminant's Chemical Abstract Services Registry Number (CASRN).
                                   Page 5 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the            EPA 815-R-15-003
                            Draft PCCL 4 Nominated Contaminants

   2)  Attribute Scores - assigned scores for each of the four CCL attributes (which are
       derived from the health effects and occurrence data presented on the CISs), which are
       defined as follows:
          a.  Potency - Potency reflects the lowest dose of a chemical that causes an adverse
             health effect. Potency for chemicals is reflected in several standard toxicological
             parameters, including the Reference Dose (RfD) or its equivalent; cancer potency,
             expressed as the concentration in water equivalent to a 10~4 cancer risk; No
             Observed Adverse Effect Level (NOAEL); or Lowest Observed Adverse Effect
             Level (LOAEL).
          b.  Severity - Severity is the adverse health effect associated with the dose that is
             used as the measure of Potency and is calibrated based on the health-related
             significance of the adverse effect (e.g., dermatitis versus cancer).
          c.  Prevalence - Prevalence is a measure of how widespread the contaminant's
             occurrence is in the environment (specifically in the United States). The data used
             to score the prevalence attribute may include the percent of public water systems
             or monitoring sites with detections of the contaminants, the number of States
             where pesticides are applied or where releases to the environment are reported or
             chemical production data in pounds per year (Ibs/year).
          d.  Magnitude - Magnitude relates to the quantity of a contaminant that may be
             found in the environment. This may be measured through the use of the median
             value concentration of detections in drinking water or ambient water or the total
             pounds of a chemical released to the environment. In cases where Magnitude data
             are not available, persistence and mobility data (i.e., chemical
             property/environmental fate parameters) were used as surrogates  for water
             occurrence or release data (see USEPA, 2009d for discussion).
   3)  Health Reference Level (HRL) - Separate HRLs are calculated for non-cancer and
       carcinogenic effects. The HRLs are expressed as a concentration of a contaminant in
       drinking water (expressed in micrograms  per liter, |ig/L).
       If potency is scored on cancer data, that data is used to calculate the cancer HRL.  If the
       potency attribute is scored on non-cancer data, the highest ranking cancer data element is
       used to calculate the cancer HRL. For cancer, an HRL can be derived either from a slope
       factor or from a 10~4 cancer risk.  For carcinogens, the HRL is the one-in-a-million (10~6)
       cancer risk expressed as a drinking water  concentration (in |ig/L).
       If potency is scored on non-cancer data, that data is used to calculate the  non-cancer
       HRL.  If the potency attribute is scored on cancer data, then the non-cancer HRL is
       calculated using the highest ranking non-cancer data element. For non-cancer effects the
       HRL can be derived from an RfD (or its equivalent), a LOAEL, or a NOAEL. For non-
       carcinogens, the HRL is obtained by multiplying the RfD times 70 kg (default body
       weight), dividing by a water intake of 2 L/day and multiplying by a 20% relative source
       contribution. If a NOAEL or a LOAEL was used for the HRL calculation the equation is
       the same as with an RfD, but default uncertainty factors are applied to the NOAEL or
       LOAEL to develop an RfD-like value (1,000 for a NOAEL and 3,000 for a LOAEL).
                                    Page 6 of 11

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                            Draft PCCL 4 Nominated Contaminants

    4)  HRL/Concentration Ratios - The HRL/concentration ratios are presented using the 90*
       percentile concentration occurrence value, if available, or the next highest percentile
       value or the maximum concentration of detections. Both the non-cancer HRL/
       concentration ratio and the cancer HRL/concentration ratio were calculated (if
       applicable). The data used to develop the ratio is noted on the CIS.
    Moving down the CIS to the next set of three data elements; from left to right are presented:
    5)  Use - Use information for the contaminant.
    6)  Three-Model Categorical Prediction -  As noted in Section 2.0 above, three calibrated
       classification models were used to generate Categorical Predictions based on the
       contaminant's attribute scores. There are  four primary Categorical Predictions: L, L?,
       NL? and NL. One of these four primary Categorical  Predictions was assigned to a
       contaminant if all three models were in agreement on the categorical prediction. If the
       three models were not in agreement, the contaminant was assigned to a category in
       between the  four primary categories. There are three "in-between" categories including:
       L?-L, NL7-L? orNL-NL?.
    7)  Status - Presents the status of the contaminant with  respect to having been listed on CCL
       3 and its status within the CCL 4 process  (i.e., was it included in the CCL 4 Universe,
       PCCL 4 or Draft CCL 4).

Health Effects Data

The remainder of the first page of the CISs presents the available health effects data for each
contaminant. Non-cancer data elements are presented first followed by cancer data elements.
Both the non-cancer and cancer data elements are generally  presented in order according to the
data hierarchy developed for scoring the potency attribute (with the highest ranking data
elements used for scoring generally being presented closer to the top of the page  and the lower
ranking elements closer to the bottom of the page). The non-cancer data are presented before the
cancer data. The column headings summarize the data element, the data source acronym, the
numerical value (or  qualitative, for cancer classification), units and the year associated with the
data element. Typically the year is the date of publication of the data, although given the
variability of the data sources' formatting it may  represent a toxicological study date or the date
when the data source website was last updated. If available,  the critical effect is noted and a
notes field is filled in if toxicological study data or other pertinent information for a particular
data element is available.

For non-cancer data elements the highest data element in the hierarchy for scoring Potency is the
RfD, NOAEL or LOAEL from various sources, with EPA's Office of Pesticide Programs and
Integrated Risk Information System (IRIS) values taking precedence over values from other
agencies or the best  available NOAEL or LOAEL from a published study.

Below the non-cancer values are the cancer values, if applicable. As with the non-cancer values,
they are presented in hierarchical fashion.  For cancer the 10"4 cancer risk, typically from EPA's
Health Advisory Tables (HAs) or IRIS, is the highest-ranking cancer data element followed by
the slope factor. The 10"4 cancer risk or the slope factor is used for Potency scoring, where
                                    Page 7 of 11

-------
EPA-OGWDW               Contaminant Information Sheets (CISs) for the            EPA 815-R-15-003
                            Draft PCCL 4 Nominated Contaminants

applicable. In addition, qualitative cancer data, including cancer classifications from EPA, the
International Agency for Research on Cancer (IARC), the U.S. National Toxicology Program
(NTP) and/or California's Office of Environmental Health Hazard Assessment (OEHHA) are
presented, although not quantitative, such values were incorporated into the PCCL screening
process.

The row for the data element used for scoring the Potency and Severity attributes is shaded grey
on the CIS.

At the bottom right of the health effects data section of the CIS are other supporting qualitative
and quantitative data. These data represent the listing of contaminants as carcinogens and/or
reproductive toxins or values that are protective of public health via the ingestion of drinking
water (e.g., EPA Drinking Water Exposure Levels (DWELs), EPA HAs, World Health
Organization (WHO) Guideline Values, and Health Canada Guideline Values).

Occurrence Data

The second page of the CISs is focused on  occurrence data. The occurrence data are generally
presented in order of the hierarchy established for scoring Prevalence and Magnitude (i.e.,
finished water data are at the top  of the page, followed by ambient water data, supplemental
water data (often studies from individual States or the primary literature),  and application/release
data, with production data and environmental fate parameters at the bottom of the page).
Finished water occurrence data is the highest ranking data element in the hierarchy used to  score
the prevalence and magnitude attributes since it represents the best estimation of the potential for
human exposure.

The row for the occurrence  data element used for scoring Prevalence and Magnitude is shaded
grey on the CIS.

The column headers for the water occurrence data include the data source; the number of total
public water systems (PWS)/sites/samples; the number of positive results  (referred to as
"detects"),  an indication as to whether the preceding values correspond to the number of PWSs,
sampling sites or samples; the percent  of detects,  and where available; the minimum, maximum,
median, 90* percentile, 99*  percentile of detects; units; sampling year(s) and a notes field.

Following the water data are data that are used to estimate potential occurrence in water in the
absence of water data. These include application rate data for pesticides in Ibs/year,
environmental release data to surface water and total environmental releases  in Ibs/year.
Following the application/release data are production data ranges for the most recent year for
which data were available at the time of CCL 4 data collection.

The final section of the CISs includes available environmental fate parameters with persistence
metrics of half-life and a degradation code  that is either based on structural modeling or the half-
life. The remaining properties relate to environmental mobility.
                                    Page 8 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                           Draft PCCL 4 Nominated Contaminants

4.0    Summary of the Microbes Classification Process from the PCCL
       to CCL and CISs Explanation

This section briefly describes the process developed under CCL 3 to select microbial
contaminants from the PCCL for the CCL 3 and explains the elements included in the microbial
CISs. The same process developed for CCL 3 was used to evaluate the nominated contaminants
for the  Draft CCL 4. A detailed description of the process developed to select microbial
contaminants for the CCL 3 is provided in Final Contaminant Candidate List 3 Microbes: PCCL
to CCL Process (USEPA, 2009g).

Microbes are evaluated for their occurrence in water and their ability to cause adverse health
effects  in humans. Pathogens on the PCCL were scored for placement on the CCL using a
scoring system to assign a numerical value to each pathogen and rank the pathogens based upon
their occurrence, health effects and waterborne disease outbreaks (WBDO). Those microbes
receiving high scores were considered for placement on the CCL.

Each microbe was scored using three scoring protocols, one protocol each for WBDO,
occurrence in water and health effects. The highest of the individual WBDO score or occurrence
score is added to the normalized health effects score to produce a composite pathogen score.
Although the composite score is not shown on the CISs, the scoring summary table at the top left
corner  of each CIS shows the values used to calculate the composite score. The formula for
calculating the final score is: highest score between the WBDO and occurrence score + [(general
population health effects score + highest sensitive population health effects score) x 5/14].

EPA developed three scoring protocols for CCL 3 to define a hierarchy of the relevance that each
of these types of data (e.g. occurrence in water, WBDO and health effects) provide in evaluating
microbes for the CCL. WBDOs  are scored on a five-level hierarchy ranging from never caused a
WBDO (score of 1) to two or more documented WDBOs in the U.S. (score of 5). Occurrence is
scored  on a three-level hierarchy ranging from not detected in the U.S. (score of 1) to detected in
drinking water in the U.S. (score of 3). Combining WBDO information and occurrence
information allowed EPA to consider: 1) pathogens that are tracked by public health surveillance
programs (i.e., CDC's Morbidity and Mortality Weekly Report) and 2) pathogens that are not yet
tracked by public health surveillance programs but for which occurrence information is available
(e.g., emerging pathogens).

The health effects scoring protocol evaluates the extent of illness produced in humans from
drinking water. These scores reflect the most common  clinical presentation and are based on data
from recent clinical microbiology manuals. The severity of disease manifestations produced by a
pathogen is evaluated across a range of potential endpoints. The seven-level hierarchy developed
for this protocol begins with mild, self-limiting illness (score of 1) and progresses to death (score
of 7). For more information on the microbes scoring process, please see Final Contaminant
Candidate List 3 Microbes: PCCL to CCL Process (USEPA, 2009g).

The scoring tables developed for CCL 3 were updated for each nominated contaminant. Since no
new  relevant data/information was found by EPA, nor provided by the nominators, the data
supporting the respective scores for CCL 3 remain the same. The references in the scoring tables
                                   Page 9 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the          EPA 815-R-15-003
                           Draft PCCL 4 Nominated Contaminants

were updated to reflect references that became available after EPA published the final CCL3.
The table presents the final scores for each of the data types under consideration and a brief
description of the data used to assign those scores with their respective references. For the
microbial CISs, please see Appendix B.

Elements of each scoring table include:

   1)  Scoring Summary - shows the scores used to calculate the final composite  score for
       each microbial contaminant which include: highest score between the WBDO and
       occurrence, health effects score for the general population and highest health effects
       score of the sensitive subpopulations.

   2)  Data Table - shows the categories for each potential score, the scoring data, if
       applicable, and reference(s) used to support a particular score. The highest ranking score
       for each of the three scoring categories is bolded. The WBDOs scoring results is
       presented first, followed by the occurrence results and the health effects.

   3)  References - presents the full references for the data presented in the table.
5.0    References

USEPA. 2009a. Drinking Water Contaminant Candidate List 3-Final. Federal Register. Vol. 74,
No. 194, p. 51850, October 8, 2009.

USEPA. 2009b. Final Contaminant Candidate List 3 Chemicals: Identifying the Universe. EPA
815-R-09-006. August 2009.

USEPA. 2009c. Final Contaminant Candidate List 3 Chemicals: Screening to a PCCL. EPA 815-
R-09-007. August 2009.

USEPA. 2009d. Final Contaminant Candidate List 3 Chemicals: Classification of PCCL to the
CCL. EPA 815-R-09-008. August 2009.

USEPA. 2009e. Final Contaminant Candidate List 3 Microbes: Identifying the Universe. EPA
815-R-09-004. August 2009.

USEPA. 2009f. Final Contaminant Candidate List 3 Microbes: Screening to the PCCL. EPA
815-R-09-0005. August 2009.

USEPA. 2009g. Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA
815-R-09-009. August 2009.

USEPA. 2009h. Contaminant Information Sheets for the PCCL Chemicals Considered for CCL
3. EPA 815-R-09-014. August 2009.
                                  Page 10 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the           EPA 815-R-15-003
                           Draft PCCL 4 Nominated Contaminants

USEPA. 2012. Request for Nominations of Drinking Water Contaminants for the Fourth
Contaminant Candidate List. Federal Register. Vol. 77, No. 89. p. 27057, May 8, 2012

USEPA. 2014a. Announcement of Preliminary Regulatory Determination for Contaminants on
the Third Drinking Water Contaminant Candidate List. Federal Register. Vol. 79, No. 202, p.
62716, October 20, 2014.

USEPA. 2014b. Protocol for the Regulatory Determinations 3 Including Appendices A-F. EPA
815-R-14-005. April, 2014.

USEPA. 2015a. Summary of Nominations for the Fourth Contaminant Candidate List. EPA 815-
R-15-001. January, 2015.

USEPA. 2015b. Data Sources for the CCL 4. EPA 815-R-15-004. January, 2015.

USEPA. 2015c. Screening Document for the Draft PCCL 4 Nominated Contaminants. EPA 815-
R-15-002.January, 2015.
                                  Page 11 of 11

-------
EPA-OGWDW              Contaminant Information Sheets (CISs) for the          EPA 815-R-15-003
                      Draft Preliminary PCCL 4 Nominated Contaminants
         Appendix 1: Chemical Contaminant Information Sheets
The following 40 pages contain tables with health effects and occurrence information for the 20
chemical contaminants nominated by the public that were included on PCCL 4 or CCL 4. Due to
the technical limitations of this document Appendix, for further assistance with reasonable
accommodation please contact Meredith Russell at Russell.meredith@epa.gov or 202-564-0814.
                                      PageA1-1

-------
al p ha-H exach I orocy cl ohexan e
CCL 4 Contaminant Information Sheet
                                                                                                                        EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
alpha-Hexachlorocyclohexane
6535
31 9846
Attribute Scores
Potency
7
Severity
8
Prevalence
4
Magnitude
3
Source
HSDB
Use
Component of benzene hexachloride (BHC) former insecticide
                                                                                                                 3-Model Categorical Prediction
                                                                                                                              L?
Health Reference Level (HRL)1: 56 ug/L
Health Reference Level (HRL)1 cancer: 0.006 ug/L

HRL/Concentration Ratio(s)
NC HRL/NAWQA 90%: 949
CAR HRL/NAWQA 90%: 0.102
Status
CCL 3: Yes
CCL 4 Universe: Yes PCCL 4: Yes Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10*-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA IRIS
OEHHA
RAIS HE
EPA IRIS
I ARC

Source
NTP
Value




0.008




1.2




Value
o.oooe
2.7
6.3
B2
2B

Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
rng/L
(mg/kg-d)"1
(mg/kg-d)"1



Female Rat

Date




9/2003




1991




Date
1988
2005
1986
1986


Male Mouse

Critical Effect




Hepatic




Biochemical - Enzyme inhibtion, induction, or
change in blood or tissue levels - hepatic
microsomal mixed oxidase (dealkylation,
hydroxylation, etc.), Biochemical - Enzyme
inhibition, induction, or change in blood or tissue
levels - catalases, Biochemical - Enzyme
inhibition, induction, or change in blood or tissue
levels - other oxidoreductases



Notes




Basis NOAEL 0.8 mg/kg-d; UF = 100.




30-day study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B. V., POB 21 1 , 1 000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 56,137,1991




Notes Other Supporting Data Source Value Units Notes
Is contaminant or
carcinogen..
list of EPA; RAIS; Yes
OEHHA;
I ARC
Slope factor taken from Is the contaminant on a list of
IRIS. reproductive toxins?
Drinking Water E
(DWEL)



Female Mouse

quivalent Level EPA HA mg/L

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1  For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2  Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                        Page A1-2

-------
al p ha-H exach I orocy cl ohexan e
CCL 4 Contaminant Information Sheet
                                                                                                                          EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
7,119

21

Sites
Sites
0.30%

0.0004

0.21

0.011

0.059

0.21

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
Toccalinoetal., 2010
STOrage and RETrieval (STORE!)
Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
512
2,785
Amount
Released



1
448
Units
Ibs/yr
Ibs/yr
Ibs/yr

Amount
Range
No Reports
Units
Ibs/yr
Samples
Sites
Number of
States




Date
2002
0.2%
16.09%
Units
States
States
States
0.0327
0
Date
1997
2010
2010

0.0327
0.617

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.0327
0
0.0327
0.0038
0.0327
0.0656
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1993-2007
Updated 201 3
Source
OPP

Value
1.2
DST
641-1,995
3.8

6.7E-06
2
7
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206

Value Date


Units Notes
years
DST = Degrades sometimes/recalcitrant;
hydrolysis only, pH = 7 (HSDB)
L/kg
dimensionless
L/kg
atm-rrp/mol
mg/L
%
                                                                                                                         Page A1-3

-------
Manganese
CCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Manganese
18823
7439965
Attribute Scores
Potency
4
Severity
1
Prevalence
10
Magnitude
9
Source
HSDB
Use
Manufacturing of stee
matches, glass, dyes,
animal food additives
alloys, in dry-cell batter
fertilizers, welding rods,
es, electrical coils, ceramics,
as oxidizing agents, and as
                                                                                                               3-Model Categorical Prediction
                                                                                                                           NL?
                                                                                                                                                                                               Health Reference Level (HRL)1: 300 ug/L
                                                                                                                                                                                              Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                       NCHRL/NIRS90%: 2.4
                                                                                                                                                                                                              Status
                                                                                                                                                                                                CCL 4 Universe: Yes     PCCL 4: Yes     Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2

Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
IOM
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
Supplemental
Supplemental
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA IRIS
I ARC
Source
NTP
Value

0,047
0.14

0.16






10
7




Value



D

Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'


Female Rat

Date

1995
2004

2001






2009
2010




Date



1988

Male Mouse

Critical Effect




1 1 mg/day = Upper Limit, amount of manganese in
typical Western diet for adults (NOAEL) 15 mg/kg-
day LOAEL increased serum manganese and
manganese dependant lymphocyte SOD activity -
Concern for neurotoxicity






Neurodevelopmental effects in mice (Moreno et al,
2009a). Significant increase in Nitre Oxide
Synthase 2 expression in brain of animals
exposed as juveniles and adults (Moreno et al,
2009b).
Impaired spontaneous motor activity in rats




Notes





Female Mouse


Notes

Reflects a modifying factor of 3 to adjust from increased bioavai lability when in drinking water
The 3-fold modifying factor for b oavailability from drinking water was applied when calculating HA rather
than in determining the RfD

Not adjusted for the
ncreased b oavailability from drinking water






Moreno et al, 2009a. Aged-Dependent Suscept bility to Manganese-Induced Neurological Dysfunction.
Toxicological Sciences 1 1 2(2): 394-404. Moreno et al, 2009b. Developmental Exposure to Manganese
Increases Adult Susceptibility to Inflammatory Activation of of Glia and Neuronal Protein Nitration.
Toxicological Sciences. 112: 405-415.
Kern et al, 2010. Preweaning Manganese Exposure Causes Hyperactivity, Disinhibition, and Spatial
Learning and Memory Deficits Associated with Altered Dopamine Receptor and Transporter Levels.
Synapse. 64: 363-378.




Other Supporting Data
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level
(DWEL)
Guideline Value (GV)
Health Advisory (HA)

Source


EPA HA
WHODWQ
EPA HA

Value


1.6
0.4
0.3

Units


mg/L
mg/L
mg/L

Notes



2011
The 3-fold modifying factor for bioavailability
from drinking water was applied when
calculating HA rather than in determining the
RfD
  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                      Page A1-4

-------
Manganese
CCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)



989



672
PWS
PWS
PWS
PWS



67.95%



1



1,341



11.96



126



673
ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
8,002

6,447

Sites
Sites
80.57%

0.051

70,000

19

180

1,300

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
Toccalinoetal., 2010
California Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
North Carolina Drinking Water Monitoring Data
Ohio Drinking Water Monitoring Data
Region 9 Tribes Drinking Water Monitoring Data
Texas Drinking Water Monitoring Data
Wisconsin Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Massachusetts Nominations Data
Minnesota Nominations Data
Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
808
4,969
1,223
2,382
775
154
6,713
1,946
1,158
47,550
4,976
1,630
Amount
Released

84,545
15,872,968
543
2,229
685
1,265
641
63
3,898
1,571
917
42,222

1,589
Units
Ibs/yr
Ibs/yr
Ibs/yr

Amount
Range
500M - < 1 B
Units
Ibs/yr
Samples
PWS
PWS
PWS
PWS
PWS
PWS
PWS
Sites
Sites
Samples
Samples
Number of
States

31
48

Date
2006
67.2%
44.9%
56%
53.1%
82.7%
40.9%
58.1%
80.7%
79.2%
88.79%

97.48%
Units
States
States
States
0.053
0.001
1
0.7
0.113
0.85
1
0.006
0.1
0

0.1
Date
1997
2010
2010

1,923
35,000
2,700
239,000
216,000
320,000
25,910
400,000
37,000
18,604,000
28,000
3,000

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
8.99
70
31
28
33
80
10
28
2
51
7
110
186
380
190
175
246
592
70
358
220
393
360
500
732
1,455
378
779
1964
239,860
290
7,000
2,386
7,490


ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1993-2007
1995-2007
1998-2005
1998-2005
1998-2005
1998-2005
1998-2005
1980-2012
2004-201 1
Updated 201 3


Source
OPP

Value

persistent






Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206









Ground Water; Mixed Public and Private Water Supplies;
Received from Massachusetts for the CCL 4 nominations;
Ayotte, J. D., J. M. Gronberg, etal. (2011). Trace Elements and
Radon in Groundwater Across the United States. U.S.
Geological Survey Scientific Investigations Report 201 1-5059:
115. (Source water for public supply wells from the Ayotte et al.,
2011 overlaps with Toccalino etal., 2010.)
Ground Water; Mixed Public and Private Water Supplies;
Received from Minnesota for the CCL 4 nominations
Value

Date


Units
days

L/kg
dimensionless
L/kg
atm-rrp/mol
mg/L
%
Notes

As elemental Mn






                                                                                                                      Page A1-5

-------
Methyl tert-butyl ether
CCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Methyl tert-butyl ether
11918
1634044
Attribute Scores
Potency
4
Severity
8
Prevalence
5
Magnitude
8
Source

Use
Octane booster
n gasoline;
manufacture of
sobutene; extrs
action solvent
                                                                                                               3-Model Categorical Prediction
                                                                                                                            L?
                                                                                                                                                                                              Health Reference Level (HRL)1: 2,100 ug/L
                                                                                                                                                                                            Health Reference Level (HRL)1 cancer: 19.4 ug/L
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                      NC HRL/UCMR 90%: 58.3
                                                                                                                                                                                                     CAR HRL/UCMR 90%: 0.539
                                                                                                                                                                                                 CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA
I ARC

Source
NTP
Value




0.3


0.01

300




Value

0.0018


3

Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-dr
(mg/kg-d)"1



Female Rat

Date




8/1996


1991

1990




Date

2005


1999

Male Mouse

Critical Effect




Hepatic: Decreased blood urea nitrogen levels.




Kidney, Ureter, Bladder - changes in bladder
weight, Blood - changes in serum composition
(e.g. TP, bilirubin, cholesterol), Nutritional and
Gross Metabolic - changes n calc um



Notes









1




Notes






Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of OEHHA Yes
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                      Page A1-6

-------
Methyl tert-butyl ether
CCL 4 Contaminant Information Sheet
                                                                                                                           EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR 1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)
3,871



19



PWS
PWS
PWS
PWS
0.49%



5



49



9.2



34.6



48.75



ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
4,328

424

Sites
Sites
9.80%

0.01

23,000

0.3

7.85

1,800

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
Toccalinoetal., 2010
California Drinking Water Monitoring Data
Florida Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
Ohio Drinking Water Monitoring Data
Region 9 Tribes Drinking Water Monitoring Data
Texas Drinking Water Monitoring Data
Wisconsin Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
832
4,419
31
1,161
1,306
219
5,660
1,142
1,855
1,210
Amount
Released

800
1,471,221

Amount
Range
>1B
115
150
7
26
6
1
41
38
101
154
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
Samples
PWS
PWS
PWS
PWS
PWS
PWS
PWS
Sites
Sites
Number of
States

6
35

Date
2006
13.8%
3.4%
22.6%
2.2%
0.5%
0.5%
0.7%
3.3%
5.4%
12.73%
Units
States
States
States

0.031
0.15
0.09
0.5
0.5
9.8
0.5
0.104
0.03
0.046
Date
1997
2010
2010

12.03
610
67.18
16
9.51
9.8
48
64.9
28.3
13,000

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.173
5.96
0.755
1.3
1.21
9.8
2.8
2.2
0.12
1.5
1.07
33
4.56
7
5.36
9.8
10.2
16.6
0.554
14.5
7.76
214
51.2
16
8.55
9.8
25.6
45.9
2.17
1,600
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1993-2007
1995-2007
2004-2007
1998-2005
1998-2005
1998-2005
1998-2005
1980-2012
2004-201 1
Updated 201 3
Source
OPP

Value
15
BS
6
0.94

5.87E-04
51,000
42
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206









Value Date


Units Notes
days
BS = Biodegrades slow (PBT)
L/kg
dimensionless
L/kg
atm-rrp/mol
mg/L
%
                                                                                                                           Page A1-7

-------
Microcystin-LR
CCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Microcystin-LR
76859
101043372
Attribute Scores
Potency
9
Severity
3
Prevalence
10
Magnitude
4
Source
Use
Use
Naturally-occurring cyanobacterial toxin
                                                                                                              3-Model Categorical Prediction
                                                                                                                           L?
                                                                                                                                                                                             Health Reference Level (HRL)1: 0.021  ug/L
                                                                                                                                                                                            Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                   HRL/Concentration Ratio(s)
                                                                                                                                                                                            NC HRL/AWWARF Typical Range MAX: 0.21
                                                                                                                                                                                                             Status
                                                                                                                                                                                 CCL 3: Yes     CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
Reference Dose (RfD)-like value
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
Primary
Literature
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA
I ARC

Source
NTP
Value








0.000003






Value






Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-1



Female Rat

Date








200S






Date






Male Mouse

Critical Effect








Liver effects






Notes






Female Mouse


Notes








Draft RfD; Basis NOAEL 3 ug/kg-d. Ueno, Y, Y. Makita, S. Nagata et al., 1998. No chronic oral toxicity of a
low-dose of microcystin-LR, a cyanobacterial hepatoxin, in female Balb/C mice. Environ. Toxicol. 1 4(1): 45-
55.






Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-8

-------
Microcystin-LR
CCL 4 Contaminant Information Sheet
                                                                                                                         EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
STOrage and RETrieval (STORE!)
US and Canadian drinking water (bloom area,
source, finished water)
US and Canadian drinking water (bloom area,
source, finished water)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP)- Application
. /-rnl\ <^

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
30
677
677
Amount
Released




Amount
Range

30
542
542
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
Sites
Sites
Sites
Number of
States




Date
2006
100%
80%
80%
Units
States
States
States

0
0.002

Date
1997
2010
2010

4.26
1,200
0.1

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.25


1.22


3.32


ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
Updated 201 3


Source
OPP

Value









Vlaximum and min mum of detects (AWWARF, Carmichael).
ncludes possible outliers.
Vlaximum of typical range of detects (AWWARF, Carmichael).
Excludes possible outliers.
Value Date


Units Notes
length of time
Degradation Code Not Available
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                         Page A1-9

-------
Nonylphenol
CCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Nonylphenol
28410
251 54523
Attribute Scores
Potency
5
Severity
7
Prevalence
10
Magnitude
6
Source
HSDB
Use
In the preparation of lubricating oil additives, resins, plasticizers, surface
active agents; antioxidants for plastics and rubber
                                                                                                              3-Model Categorical Prediction
                                                                                                                          L?-L
                                                                                                                                                                                              Health Reference Level (HRL)1: 105 ug/L
                                                                                                                                                                                             Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                     NC HRL/Kolpin Max: 2.6
                                                                                                                                                                                                             Status
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
Supplemental
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA
I ARC

Source
NTP
Value








60
15
2


580

Value






Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat

Date









2004
2001




Date






Male Mouse

Critical Effect









Reproductive effects
Endocrine - androgenic, Reproductive - Paternal
Effects - testes, epididymis, sperm duct


Details of toxic effects not reported other than
lethal dose value
Notes









World Health Organization (WHO)
REPTED Reproductve Toxicology. (Pergamon Press Inc., Maxwell House, FairviewPark, Elmsford, NY
10523) V.1- 1987- Volume(issue)/page/year 15,293,2001


NTIS National Technical Informaton Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for
Scientific & Technical Information. Volume(issue)/page/year OTS0573098

Notes






Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-10

-------
Nonylphenol
CCL 4 Contaminant Information Sheet
                                                                                                                       EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
Kol pin etal., 2002
STOrage and RETrieval (STORET)
Snyder, 2008
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
85
15
20
Amount
Released




Amount
Range
<500K
43
5

Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
Sites
Sites
Samples
Number of
States




Date
2006
50.6%
33.33%
17%
Units
States
States
States

3.26

Date
1997
2010
2010

40
5.17
0.104

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0,8
3.74
0.084

4.52


5.11

ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1999-2000
Updated 201 3

Source
OPP

Value

BST
31,000
5.71

1.1E-06
6.35
18
Mational Surface Water Reconnaissance; Kolpin, etal., 2002.
Env. Sci, &Technol., 36(6), pp. 1202-1211.

=inished Drinking Water Monitoring; Snyder, Shane A. 2008.
Ozone: Science and Engineering. 30(1): 65-69.
Value Date


Units Notes
days
BST = biodegrades sometimes/recalcitrant;
aerobic only
L/kg
dimensionless At 20 degrees Celsius
L/kg
atm-nf/mol
mg/L At 25 degrees Celsius
%
                                                                                                                      Page A1-11

-------
Perfluorooctanoic acid (PFOA)
CCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Perfluorooctanoic acid (PFOA)
6614
335671
Attribute Scores
Potency
6
Severity
3
Prevalence
10
Magnitude
6
Source
HSDB
Use
Production of fluoropolymers (e.g., Teflon) and fluoroelastomers; in fire-
fighting applications, cosmetics, greases and lubricants, paints, polishes
and adhesives
                                                                                                               3-Model Categorical Prediction
                                                                                                                             L?
                                                                                                                                                                                                Health Reference Level (HRL)1: 1.1 ug/L
                                                                                                                                                                                               Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                      HRL/Concentration Ratio(s)
                                                                                                                                                                                                      NC HRL/MN MW MAX: 1.22
                                                                                                                                                                                                                Status
                                                                                                                                                                                   CCL 3: Yes      CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
Supplemental
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA
I ARC

Source
NTP
Value










0.4S




Value






Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat

Date










2008




Date






Male Mouse

Critical Effect










Increased maternal liver weight at term




Notes






Female Mouse


Notes










BMDL10, Lau, 2006. Tox. Sci., 90, 2, pp. 510-518. EPA Provisional HA:
http.7/www.epa.gov/waterscience/criteria/drinking/pha-PFOA_PFOS.pdf




Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)
Health Advisory (HA) EPA HA 0.4 ug/L January 2008; Provisional Health Advisory:
http://www.epa.gov/waterscience/criteria/drinkin
g/pha-PFO A_PFOS.pdf

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                      Page A1-12

-------
 Perfluorooctanoic acid (PFOA)
 CCL 4 Contaminant Information Sheet
                                                                                                                          EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
STOrage and RETrieval (STORET)
Minnesota (MN) Department of Health (DOH) -
Aggregate of MN Wells
Minnesota (MN) Department of Health (DOH) -
Select MN Municipal Wells
Minnesota (MN) Department of Health (DOH) -
Select MN Non-Community Wells
Minnesota (MN) Department of Health (DOH) -
Select MN Private Wells
Little Hocking, OH Municipal Wells (FW)
NJDEP
Cape Fear Drainage Basin
Upper Mississippi Drainage Basin
Tennessee River, Alabama
U.S. PWS Study
Lake Erie and Lake Ontario
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total
318
85
37
22
26

23
80
175
40
6
16
Amount
Released



232
7
6
0
1

18

168
18

16
Units
Ibs/yr
Ibs/yr
Ibs/yr
Sites
Sites
Sites
Sites
Sites
N/A
Sites
Sites
Sites
Sites
Sites
Sites
Number of
States




Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
Amount
Range
<500K
Units
Ibs/yr
Date
2006
72.96%
8.2%
16.2%
0%
3.9%

78.3%
82.3%
97.1%
45%

100%
Units
States
States
States
0.000988




1.5
0.004


0.14
O.005
0.015
Date
1997
2010
2010

48,500
0.9
0.9

0.67
7.2
0.039
0.287
0.125
0.598
0.12
0.07

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.144






0.0126
0.00207
0.379

0.04
47.7











1,304











ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
Updated 201 3






2006
2008


2003
Source
OPP

Value

BST
631  7.9


0.091

10

Targeted Sampling 2004-2005 - H. Goeden and J. Kelly.
Perfluorochemicals n Minnesota, MN DOH, 2/27/06.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly.
Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly.
Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Targeted Sampling 2004-2005 - H. Goeden and J. Kelly.
Perfluorochemicals in Minnesota, MN DOH, 2/27/06.
Emmett, etal., 2006. J. Occ. Env. Med. Little Hocking, OH;
data from 2002-2005; no data on # PWSs/sites sampled
Targeted study "Determination of Perfluorooctanoic Acid
(PFOA) in Aqueous Samples, Final Report." Jan 2007, NJDEP,
Division of Water Supply.
Makayama et al. 2007. Perfluorinated Compounds in the Cape
Fear Drainage Basin in N.C. Env. Sci. & Tech., 41 , 5271-5276.
Makayama et al. 2010. Determination of Perfluor nated
Compounds in the Upper Mississippi River Basin. Env. Sci. &
Tech., 44, pp. 4103-4109.
Targeted sampling - 35 river miles downstream of PFC
manufacturing facility. Hansen et al. 2002. Quantitative
Characterization of Trace Levels of PFOS and PFOA in the
Tennessee River. Env. Sci. &Tech., 36, pp. 1681-1685
Quinones, O. and S.A. Snyder. 2009. Occurrence of
oerfluoroalkyl carboxylates and sulfonates in drinking water
utilities and related waters from the United States. Env. Sci. &
Tech., 43, pp. 9089-9095.
Boulanger et al. 2004. Detection of Perfluorooctane Surfactants
in Great Lakes Water. Env. Sci. & Tech., 38, pp. 4064-4070.
Value

Date


Units
length of time

L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
Notes

BST = Biodegrades sometimes/recalcitrant
(PBT); BST is the highest category available
to be awarded to a recalcitrant contaminant
Zareitalabad, etal., 2013





                                                                                                                         Page A1-13

-------
Permethrin
CCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Permethrin
35815
52645531
Source
HSDB
Use
Insecticide
Attribute Scores
Potency Sev
4 E

srity Prevalence
10

Magnitude
7

3-Model Categorical Prediction
L?-L
                                                                                                                                                                                              Health Reference Level (HRL)1: 1,750 ug/L
                                                                                                                                                                                           Health Reference Level (HRL)1 cancer: 3.65 ug/L
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                      NC HRL/SWC EEC:  1,944
                                                                                                                                                                                                      CAR HRL/SWC EEC: 4.05
                                                                                                                                                                                                 CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: Yes
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Fa,ctor (Oral)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
EPA OPP
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0.25
0.05

0.05
0.2
0.05








Value

0.0096


Likely
3

Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat

Date
2009
1986

1986
2003
1999








Date

2009


2009
1991

Male Mouse

Critical Effect
Neurotox/Clinical signs (i.e., aggression, abnormal
and/or decreased movement) and ncreased body
temperature. Q1 * 0.0096 (mg/kg-d)-1 . See CAR
Increased liver weight


Neurol.









Notes







Female Mouse


Notes
Basis NOAEL = 25 mg/kg-d, UF = 100 (rat study)
Basis = NOEL 5 mg/kg-d; UF = 100.


Minimal Risk Level - Intermediate Exposure Duration









Other Supporting Data Source Value Units Notes
Is contaminant on list of EPA; IARC Yes
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-14

-------
 Permethrin
 CCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                       EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Centerfor Food and Agricultural Policy
(NCFAP) - Application
Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
35
1,828
722
Amount
Released
1,066,056
0
2,116
0
0
1
Units
Ibs/yr
Ibs/yr
Ibs/yr

Amount
Range

Units
Ibs/yr
PWS
Sites
Sites
Number of
States
48
0
5

Date
2006
0%
0%
0.14%
Units
States
States
States


0.348
Date
1997
2010
2010



0.348

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.


0.348


0.348


0.348
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1995-2007
2004-201 1
Updated 201 3
Source
OPP

Value

BF/BST
178,000
6.5

1.87E-06
0.006
6



Value Date
SW Chronic = 0.9 ug/L; GW Chronic = 0 ug/L

Units Notes
length of time
BF = Biodegrades fast; BST = Biodegrades
sometimes/recalcitrant
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                      Page A1-15

-------
Azinphos-m ethyl
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Azinphos-methyl
3200
86500
Attribute Scores
Potency
6
Severity
3
Prevalence
8
Magnitude
3
Source
HSDB
Use
Insecticide
                                                                                                               3-Model Categorical Prediction
                                                                                                                            NL?
                                                                                                                                                                                               Health Reference Level (HRL)1: 10.5 ug/L
                                                                                                                                                                                              Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                     NCHRL/NAWQA90%:  69.5
                                                                                                                                                                                                               Status
                                                                                                                                                                                                 CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0.0015




0.005



0.91




Value



Not likely


Male Rat
Equivocal
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat
Negative
Date
200S




1991



1997




Date



2006


Male Mouse
Negative
Critical Effect
Red blood cell cholinesterase inhibition; increased
incidence of diarrhea








Brain and Coverings - other degenerative
changes, Blood - other changes, Biochemical -
Enzyme inhibition, induction, or change in blood or
tissue levels - true cholinesterase



Notes
Basis NOAEL = 0.149 mg/kg-d; UF = 100 (dog study)








FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2 Volume(issue)/page/year 35,101,1997; 13-wkrat
study




Notes






Female Mouse
Negative
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of UMD Yes
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)
Maximum Acceptable Concentration CADW 0.2 mg/L Canadian Drinking Water Maximum Acceptable
(MAC) Concentration

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1  For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2  Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-16

-------
Azinphos-m ethyl
PCCL 4 Contaminant Information Sheet
                                                                                                                        EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
7,103

145

Sites
Sites
2.04%

0.002

3.37

0.027

0.151

0.932

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
12
11
5
323
228
894
5
1,828
831
Amount
Released
2,091,014



Amount
Range

0
2
0
8
5
0
0
0
24
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
PWS
Sites
Sites
Number of
States
42



Date
2006
0%
18.2%
0%
2.5%
2.2%
0%
0%
0%
2.9%
Units
States
States
States


0.017






0
Date
1997
2010
2010


0.017

0.144
0.114



0.864

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.

0.017






0.048

0.017






0.196

0.017






0.649
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
1993-2007
1995-2007
2004-201 1
Updated 201 3
Source
OPP

Value
27.9
DS
487-4,644
2.75

2.4E-08
20.9
27
Drinking water monitoring
=inished
Raw
Ambient Water; Method 2001 (GC/MS)
Finished Water; Method 2001 (GC/MS)
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206



Value Date


Units Notes
days
DS = Degrades slow (HSDB)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                       Page A1-17

-------
Bentazon
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Bentazon
28242
25057890
Attribute Scores
Potency
5
Severity
6
Prevalence
9
Magnitude
4
Source
HSDB
Use
Former herbicide
                                                                                                               3-Model Categorical Prediction
                                                                                                                            L?
                                                                                                                                                                                              Health Reference Level (HRL)1: 210 ug/L
                                                                                                                                                                                             Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                     NC HRL/NAWQA 90%: 276
                                                                                                                                                                                                              Status
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS
Value
0,03
0.03
0.03
0.03

0.1








Source
EPA
OEHHA
RAIS HE
EPA IRIS
EPA OPP
I ARC

Source
NTP
Value



E
E


Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)"1
(mg/kg-d)-1




Female Rat

Date
1994
1998
1999
1989

1998








Date



1998
1994


Male Mouse

Critical Effect
Hematological changes suggestive of anemia,
decreased weight gain, intestinal inflammation,
and congestion of the small intestine and spleen
(dog study)
Blood loss into the gastrointestinal tract;
Coagulation defect in male & female dogs.
Circulatory system.

blood loss in gastrointestinall tract; coagulation
defect









Notes
UF = 100; Basis NOAEL = 3.2 mg/kg-day
Allen etal., 1989. Dog study; UF = 100, Basis NOAEL 3.2 mg/kg-d

UF = 100; dog study










Notes







Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)
Guideline Value (GV) WHODWQ 300 ug/L World Health Organization Drinking Water
Guideline Value

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-18

-------
 Bentazon
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                      EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
4,540

197

Sites
Sites
4.34%

0.002

11.46

0.1

0.76

4.79

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
STOrage and RETrieval (STORET)

Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)

Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
5,583
13
7
589
1,807
1
694
Number
225
312

Amount
Released
7,749,130



Amount
Range

2
7
5
16
6
0
75
Number of
Detects
21
80

Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Sites
Sites
Samples
PWS
PWS
Sites
PWSs/
Sites/
Samples
Samples
Samples

Number of
States
45



Date
2006
0.04%
53.8%
71.4%
2.7%
0.3%
0%
10.81%
Percent
with Detects
9.3%
25.6%

Units
States
States
States

0.23
0.0003
0.0003
0.0046
0.023

0
Minimum
Cone.
(Detects)



Date
1997
2010
2010

6.2
0.031
0.194
0.491
6.2

16
Maximum
Cone.
(Detects)
0.019
0.344

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
3.11
0.0016
0.0017
0.00995
2.9

0.191
Median
Cone.
(Detects)


5.58
0.00712
0.012
0.0711
5.24

2.13
75th
Percentile
(Detects



0.016
0.061
0.434
6.1

12.4
95th
Percentile
(Detects)
0.019
0.021
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Cone.
Units
ug/L
ug/L

Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1993-2007
1995-2007
1998-2005
Updated 201 3
Date
1999
1999

Source
OPP

Value
6.7-50
BS
37.5
2.34

2.18E-09
500
36
Drinking water monitoring
=inished
Raw
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206



Notes
Finished Water; Method 9060 (HPLC/MS)
Ambient Water; Method 9060 (HPLC/MS)

Value Date


Units Notes
days
BS = Biodegrades slow (HSDB)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                      Page A1-19

-------
Bisphenol A
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Bisphenol A
2918
80057
Source
HSDB
Use
Production of polycarbonate and epoxy resins. Formerly used as
fungicide.
Attribute Scores
Potency Sev
4 :

3rity Prevalence
10

Magnitude
5

3-Model Categorical Prediction
NL?
                                                                                                                                                                                               Health Reference Level (HRL)1: 350 ug/L
                                                                                                                                                                                              Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                  NC HRL/NREC NA SW MED: 1,750
                                                                                                                                                                                                              Status
                                                                                                                                                                                                 CCL 4 Universe: Yes
                                                                                                                                                                                                                                   Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
No Observed Adverse Effect Level (NOAEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
Supplemental
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA
I ARC

Source
NTP
Value

0.05

0.05





0.0006
2.5




Value






Male Rat
Equivocal
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)"1
(mg/kg-d)"1



Female Rat
Equivocal
Date

1988

1988





2011





Date






Male Mouse
Equivocal
Critical Effect

Reduced body weight







Increase in adjusted terminal end bud (TEB)
numbers in the offspring of mice for LOAEL
related to NOAEL




Notes

Basis = LOAEL 50 mg/kg-d; UF = 1,000







LOAEL = 0.003 mg/kg-d. Ayyanan, A., Laribi, O., Schuepbach-Mallepell, S. etal. 2011. Perinatal exposure
to bisphenol A increases adult mammary gland progesterone response and cell number. Mol. Endicronol.
25(11): 1915-1923.
26-week oral study n rat. GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 1 1 3095 Moscow, USSR) V.1- 1936 - Volume(issue)/page/year 33(7), 25, 1968.




Notes






Female Mouse
Negative
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of UMD Yes
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-20

-------
 Bisphenol A
 PCCL 4 Contaminant Information Sheet
                                                                                                                       EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)

85




35



Sites
Sites
Sites
Sites
Sites

41.20%
21.07%
10.78%












0.14
0.2
0.2











ug/L
ug/L
ug/L
ug/L
ug/L
1992-2001
1999-2004
1999-2004
1999-2004
1999-2004

Surface water; National Reconnaissance
Surface water; National Aggregate. Size of dataset not reported.
Ground water; National Aggregate. Size of dataset not reported.

Supplemental Water Data
Kolpinetal., 2002
Focazioetal., 2008
Hopple etal., 2009
Hopple etal., 2009
Hopple etal., 2009
Kingsbury etal., 2008
Kingsbury etal., 2008
Kingsbury etal., 2008
STOrage and RETrieval (STORET)
Stackelberg, etal., 2007
Stackelberg, etal., 2007
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total
85
73
43
47
212
145
87
87
33
12
12
Amount
Released

6,240
3,296,213

7






1


Units
Ibs/yr
Ibs/yr
Ibs/yr
Sites
Sites
Samples
Samples
Samples
Samples
Samples
Samples
Sites
Samples
Samples
Number of
States

5
27

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
Amount
Range
>1B
Units
Ibs/yr
Date
2006
41.2%
9.6%
2.3%
0%
0.9%
0%
9.2%
4.7%
3.03%
17%
67%
Units
States
States
States








0.28


Date
1997
2010
2010

12
1.9
2.5

6.4

0.44
0.67
0.28
0.22
0.36

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.14







0.28










0.28










0.28


ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
1999-2000
2001
2002-2005
2002-2005
2002-2005
2002-2005
2002-2005
2002-2005
Updated 201 3


Source
OPP

Value

BFA-BST
75,200
3.32

9.2E-12
120
8
Mational Surface Water Reconnaissance; Kolpin
Env. Sci. &Technol., 36(6), pp. 1202-1211.
etal., 2002.
NREC II Raw Drink ng Water; Focazio, et al., 2008. Sci. Tot.
Env., 402(2-3), pp. 201-216.
Ground water; Phase 2; Source water; Hopple et al., 2009,
Anthropogenic organic compounds in source water of selected
community water systems that use groundwater, 2002-05:
USGS Sci. Investigations Report 2009-5200, p. 74
Ground water; Phase 2; Finished water; Hopple et al., 2009
Ground water; Phase 1; Source water; Hopple et
al., 2009
Surface water; Phase 1 ; Source water; Kingsbury et al., 2008
Surface water; Phase 2; Finished water; Kingsbury et al., 2008
Surface water; Phase 2; Source water; Kingsbury et al., 2008,
Anthropogenic organic compounds in source water of nine
community water systems that withdraw from streams, 2002-05:
USGS Sci. Investigations Report 2008-5208, p. 66

New Jersey Finished Drinking Water; Stackelberg, etal., 2007.
Sci. Tot. Environ., 377(2-3), pp. 255-272.
New Jersey Surface Water; Stackelberg, et al., 2007. Sci. Tot.
Environ., 377(2-3), pp. 255-272.
Value


Units
length of time

L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
Date


Notes

BFA = Biodegrades fast with acclimation;
BST = Biodegrades sometimes/recalcitrant






                                                                                                                      Page A1-21

-------
Butyl benzyl phthalate
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Butyl benzyl phthalate
3168
85687
Attribute Scores
Potency
4
Severity
3
Prevalence
8
Magnitude
8
Source
HSDB
Use
Chemics
al intermediate
Pis
asticizer

                                                                                                               3-Model Categorical Prediction
                                                                                                                            NL?
                                                                                                                                                                                              Health Reference Level (HRL)1: 1,400 ug/L
                                                                                                                                                                                              Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                        NC HRL/TX90%: 63.1
                                                                                                                                                                                                               Status
                                                                                                                                                                                                 CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
EPA PPRTV
OEHHA
RAIS HE
EPA IRIS
I ARC

Source
NTP
Value

0.2
0.2
0.2



1.3

100




Value

0.0019


C
3

Male Rat
Some
Evidence
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-d)"1



Female Rat
Equivocal
Evidence
Date

1993
1989
1989



1998

2000




Date

2002


1988
1999

Male Mouse
Not Tested
Critical Effect

Significantly increased liver-to-body weight and
liver to-brain weight ratios

Significantly increased liver-to-body weights liver-
to-brain weight ratios





Gastrointestinal - changes n structure or function
of salivary glands, Kidney, Ureter, Bladder -
changes in kidney weight; endocrine - other
changes



Notes

NTP, 1 985. Basis NOAEL = 1 59 mg/kg-d; UF = 1 ,000 (rat study)

NTP, 1985; Basis NOAEL/LEL, rat, liver, brain, UF=1000



Hammond et al. 1987; Basis BMD 132 mg/kd/day, UF = 100, rat

oral study in rat; REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year 14,513,2000




Notes





Vol. 73, 1999

Female Mouse
Not Tested
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA 7 mg/L Drinking Water Equivalent Level
(DWEL)

  Note: Highlighted data indicate value was used i
  1 For the CCL process HRLs were calculated by
  2 Cancer classifications were only used for screei
n attribute scoring. Blank fields indicate there were no data available.
converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
ming. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-22

-------
 Butyl benzyl phthalate
 PCCL 4 Contaminant Information Sheet
                                                                                                                          EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
California Drinking Water Monitoring Data
Florida Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
Texas Drinking Water Monitoring Data
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy

. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
851
264
5
2
2,108
1,221
Amount
Released




Amount
Range
50M-<
100M
24
16
0
0
4
248
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
PWS
PWS
PWS
PWS
Sites
Number of
States




Date
2006
2.8%
6.1%
0%
0%
0.2%
20.31%
Units
States
States
States

0.004
0.003


3.97
0
Date
1997
2010
2010

124
8.5


28,4
629.5

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.2
0.074


8,99
0.043
59
4.3


22.2
0.97

8.4


26
27.2
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

1995-2007
2004-2007
1998-2005
1998-2005
Updated 201 3
Source
OPP

Value

BF
9,359
4.73

1.26E-06
2.69
22
Drinking water monitoring





Value Date


Units Notes
length of time
BF = Biodegrades fast (BIODEG)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                         Page A1-23

-------
Carbaryl
PCCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Carbaryl
2448
63252
Attribute Scores
Potency
5
Severity
5
Prevalence
1
Magnitude
5
Source
HSDB
Use
Insecticide; veterinary medication
                                                                                                              3-Model Categorical Prediction
                                                                                                                           NL?
                                                                                                                                                                                              Health Reference Level (HRL)1: 70 ug/L
                                                                                                                                                                                           Health Reference Level (HRL)1 cancer: 40 ug/L
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                     NC HRL/UCM R2 90%: 70
                                                                                                                                                                                                    CAR HRL/UCM R2 90%: 40
                                                                                                                                                                                                CCL 4 Universe: Yes     PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
EPA OPP
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0,01
0.1
0.01

0.008



0.23




Value

0.000875


Likely
3

Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)"1
(mg/kg-d)-1
(mg/kg-d)-1



Female Rat

Date
2007
1985
2006

2001



1975




Date

2002,
updated
2008


2007
1987

Male Mouse

Critical Effect
0.01 mg/kg-day is the acute RfD based on brain
cholinesterase inhibition PND 1 1 . Q1* 0.000875
(mg/kg-d)"-1 - Likely; see CAR
Kidney; liver






Immunological Including Allergic - decrease in
humoral immune response



Notes
Basis NOAEL = 1 mg/kg-d, UF = 100 (rat study)
Carpenter et al., 1961; Basis NOAEL 9.6 mg/kg/day, rat, UF=100, kidney Silver






oral study in rabbit; TXAPA9 Tox cology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year 32,587,1975




Notes

Incidence of
hemangiosarcomas in
mice; 2002 and 2007
Carbaryl Occupational
Risk Assessment in
August 2008 Amended
RED


Likely to be carcinogenic
in humans; 2003 and
2007 Carbaryl
Occupational Risk
Assessment in August
2008 Amended RED
Vol. 12, Suppl. 7, 1987

Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of EPA; IARC Yes
carcinogens?
Is the contaminant on a list of UMD Yes Teratogen
reproductive toxins?
Drinking Water Equivalent Level EPA HA 0.4 mg/L 2006; Drinking Water Equivalent Level
(DWEL)
Maximum Acceptable Concentration CADW 0.09 mg/L Canadian Drinking Water Maximum Acceptable
(MAC) Concentration

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                    Page A1-24

-------
Carbaryl
PCCL 4 Contaminant Information Sheet
                                                                                                                       EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)


12,678



13

PWS
PWS
PWS
PWS


0,10%



0.18



3



0.18



1



3

ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)
7,142
85


697
14


Sites
Sites
Sites
Sites
9.76%
16.50%
5.05%
0.12%
0.0005



33.5



0.0167
0.04
0.17
0.9
0.138



1.2



ug/L
ug/L
ug/L
ug/L
1992-2001
1999-2004
1999-2004
1999-2004

Surface water; National Reconnaissance
Surface water; National Aggregate. Size of dataset not reported.
Ground water; National Aggregate. Size of dataset not reported.
Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
Florida Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
North Carolina Drinking Water Monitoring Data
Ohio Drinking Water Monitoring Data
Region 9 Tribes Drinking Water Monitoring Data
South Dakota Drinking Water Monitoring Data
Wisconsin Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
4,671
7
13
323
312
228
225
898
1,488
8
22
2,477
43
232
256
1,447
1,831
1,213
Amount
Released
4,857,542
12
1,653

Amount
Range

1
5
5
7
2
2
0
6
2
0
0
2
0
0
0
1
1
21
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
Samples
Samples
PWS
PWS
PWS
PWS
PWS
PWS
PWS
PWS
Sites
Sites
Number of
States
48
3
7

Date
2006
0.02%
71.4%
38.5%
2.2%
0.6%
0.9%
0%
0.7%
0.1%
0%
0%
0.1%
0%
0%
0%
0.1%
0.05%
1.73%
Units
States
States
States

3.5
0.0078
0.005




0.00277
3.5


22



1
0.007
0
Date
1997
2010
2010

3.5
0.33
0.3
0.047
0.063
0.041

0.0196
24


36



1
0.007
50

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
3.5
0.02
0.02




0.00736
13.8


29



1
0.007
0
3.5
0.092
0.16




0.0146
22


34.6



1
0.007
5.5

0.31
0.29




0.0191
23.8


35.9



1
0.007
38.3
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
1999
1999
1993-2007
1995-2007
2004-2007
1998-2005
1998-2005
1998-2005
1998-2005
1990-2007
1980-2012
2004-201 1
Updated 201 3
Source
OPP

Value
38
BSA
242
2.36

4.36E-09
110
13
Drinking water monitoring
Raw
=inished
Ambient Water; Method 2001 (GC/MS)
Ambient Water; Method 9060 (HPLC/MS)
Finished Water; Method 2001 (GC/MS)
Finished Water; Method 9060 (HPLC/MS)
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206










Value Date


Units Notes
days
BSA = Biodegrades slow with acclimation
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                      Page A1-25

-------
Chlorothalonil
PCCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Chlorothalonil
12375
1897456
Attribute Scores
Potency
5
Severity
6
Prevalence
4
Magnitude
4
Source
HSDB
Use
Fungicide; bacteriocide
                                                                                                              3-Model Categorical Prediction
                                                                                                                           NL?
                                                                                                                                                                                              Health Reference Level (HRL)1: 140 ug/L
                                                                                                                                                                                           Health Reference Level (HRL)1 cancer: 4.6 ug/L
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                    NCHRL/NAWQA90%: 342
                                                                                                                                                                                                   CAR HRL/NAWQA 90%: 11.2
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
Supplemental
RTECS
HSDB
CTD JPN
RTECS

Source
EPA HA
EPA
EPA OPP
OEHHA
RAIS HE
EPA OPP
EPA
I ARC

Source
NTP
Value
0.02
0.015
0.015
0.015

0.03



1.5
75




Value
0.15
0.46
0.00766
0.0031
0.011
Likely
B2
2B

Male Rat
Positive
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
mg/L
(mg/kg-d)"1
(mg/kg-d)"1
(mg/kg-d)"1




Female Rat
Positive
Date
1999
1987
1988
1987

1994




1990




Date
1988
1999
1999
2005

1999
1988
1999

Male Mouse
Negative
Critical Effect
Increased kidney weights & hyperplasia of the
proximal convoluted tubules in the kidneys, ulcers
Sforestomach hyperplasia. Q1* 0.00766
(mg/kgday)A-1 . Group B2. See CAR
Renal tubular epithelial vacuolation

Tubular epithelial vacuolat on






Kidney, Ureter, Bladder - changes in tubules
(including acute renal failure, acute tubular
necrosis), Kidney, Ureter, Bladder - changes in
bladder weight




Notes

Corresponds with OPP
slope factor.





Vol. 73, 1999; note:
OEHHA lists lARCs
cancer class as 3.

Female Mouse
Negative

Notes
Basis NOAEL = 2 mg/kg-d; UF = 100
Basis NOEL = 1.5 mg/kg/day, UF = 100, kidney, dog, oral (Diamond Shamrock Chemical, 1970a)

Diamond Shamrock Chemical, 1970, Basis NOEL/LEL, MF = 1, kidney, dog, UF = 100






90-day oral study in rat; TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year 53,155,1990




Other Supporting Data Source Value Units Notes
Is contaminant on list of CACART; Yes
carcinogens? IARC; EPA;
OEHHA;
RAIS
Is the contaminant on a list of CACART Yes
reproductive toxins?
Drinking Water Equivalent Level EPA HA 0.5 mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-26

-------
Chlorothalonil
PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                         EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
4,547

15

Sites
Sites
0.33%

0.007

0.71

0.05

0.41

0.71

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
T ' R I I t fTRh ^ f W
oxics eease nven ory ( ) ur ace a er
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
4,099
6
6
225
312
507
1,296
694
Amount
Released
11,916,713
146
91,363

Amount
Range

0
0
0
0
0
0
0
12
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
PWS
Sites
Number of
States
48
1
7

Date
2006
0%
0%
0%
0%
0%
0%
0%
1.73%
Units
States
States
States








0
Date
1997
2010
2010








56

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.







0







1.93







47.1
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
1993-2007
1995-2007
Updated 201 3
Source
OPP

Value

BF
2,392
3.05

2E-06
0.6
7
Drinking water monitoring
Raw
=inished
Finished Water; Method 9060 (HPLC/MS)
Ambient Water; Method 9060 (HPLC/MS)
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206


Value Date


Units Notes
length of time
BF = Biodegrades fast (BIODEG)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                        Page A1-27

-------
Dichlorvos
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dichlorvos
2444
62737
Attribute Scores
Potency
6
Severity
3
Prevalence
1
Magnitude
1
Source
HSDB
Use
Insecticide; veterinary medicine
                                                                                                               3-Model Categorical Prediction
                                                                                                                            NL
                                                                                                                                                                                               Health Reference Level (HRL)1: 3.5 ug/L
                                                                                                                                                                                            Health Reference Level (HRL)1 cancer: 0.1 ug/L
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                   No data for calculating HRL ratio
                                                                                                                                                                                                               Status
                                                                                                                                                                                   CCL 3: No      CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS
Value
0.0005
0.0005

0.0005
0.0005
0.004



0.625



Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Source
EPA IRIS
OEHHA
RAIS HE
EPA OPP
EPA
I ARC

Source
NTP
Value
0.01
0.41
0.29
Suggestive
B2
2B

Male Rat
Some
Evidence
Units
mg/L
(mg/kg-d)"1
(mg/kg-d)"1




Female Rat
Equivocal
Evidence
Date
2006
1993

1990
1997
1993



1974




Date
1988
2005

2006
1989
1991

Male Mouse
Some
Evidence
Critical Effect
Plasma and RBCcholinesterase nhibition (dog
study)
Cholinesterase inhibition

Plasma and RBC ChE inhib tion; blood
Neurol.




Brain and Coverings - other degenerative
changes, Kidney, Ureter, Bladder - urine volume
increased, Biochemical - Enzyme inhibition,
induction, or change in blood or tissue levels - true
Cholinesterase



Notes
UF = 100; Basis NOAEL = 0.05 mg/kg-day
AMVAC Chemical Corporation, 1990, NOAEL, dog, UF=100; Basis NOAEL = 0.05 mg/kg-d

AMVAC Chemical Corporation, 1990, NOAEL/LOAEL, dog, UF=100
UF = 100




90-day dog study; NYZZA3 Nippon Yakuzaish kai Zasshi. Journal of the Japan Pharmaceutical
Association. (Nippon Yakuznishikai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1949-
Volume(issue)/page/year26,739,1974




Notes




Gl, pancreas, leukemia;
NTP, 1986
Vol. 53

Female Mouse
Clear Evidence
Other Supporting Data Source Value Units Notes
Is contaminant on list of EPA; Yes
carcinogens? RAISHE;
OEHHA;
IARC;
CACART
Is the contaminant on a list of UMD Yes Teratogen list
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used i
  1 For the CCL process HRLs were calculated by
  2 Cancer classifications were only used for screei
n attribute scoring. Blank fields indicate there were no data available.
converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
ming. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-28

-------
 Dichlorvos
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                        EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)
National Reconnaissance of Emerging
Contaminants (NREC)








Sites
Sites
Sites
Sites

0,00%
0.00%





















ug/L
ug/L
ug/L
ug/L
1992-2001
1999-2004
1999-2004
1999-2004

Surface water; National Aggregate. Size of dataset not reported.
Ground water; National Aggregate. Size of dataset not reported.

Supplemental Water Data
California Department of Health Services
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Hopple etal., 2009
Hopple etal., 2009
Hopple etal., 2009
California Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
107
317
221
221
49
49
68
1,828
321
Amount
Released

0
265

Amount
Range
No Reports
0
0
0



0
1
7
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Samples
Samples
Samples
Samples
Samples
PWS
Sites
Sites
Number of
States

0
2

Date
2002
0%
0%
0%
0%
0%
0%
0%
0.05%
2.18%
Units
States
States
States








0.01
0.07
Date
1997
2010
2010








0.01
0.218

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.







0.01
0.178







0.01
0.199







0.01
0.216
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

1999
1999
2002-2005
2002-2005
2002-2005
1995-2007
2004-201 1
Updated 201 3
Source
OPP

Value
<1-3.5
DF
40.2
1.47

5.75E-07
8,000
27
Drinking water monitoring
Ambient Water; Method 9002 (GC/MS)
Finished Water; Method 9002 (GC/MS)
Ground water; Phase 1; Source water; Hopple et al., 2009
Ground water; Phase 2; Finished water; Hopple et al., 2009
Ground water; Phase 2; Source water; Hopple et al., 2009,
Anthropogenic organic compounds in source water of selected
community water systems that use groundwater, 2002-05:
USGS Sci. Investigations Report 2009-5200, p. 74



Value Date


Units Notes
days
DF = Degrades fast (HSDB)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                       Page A1-29

-------
Dicofol
PCCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Dicofol
5106
115322

Source
HSDB
Use
Insecticide
Attribute Scores
Potency
6
Severity
3
Prevalence
10
Magnitude
6
                                                                                                              3-Model Categorical Prediction
                                                                                                                            L?
                                                                                                                                                                                              Health Reference Level (HRL)1: 2.8 ug/L
                                                                                                                                                                                             Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                   NC HRL/SW Chronic EEC: 5.6
                                                                                                                                                                                                              Status
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0.0004




0.002



22.5




Value



C
3

Male Rat
Negative
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat
Negative
Date
1998




1992



2001




Date



1998
1987

Male Mouse
Positive
Critical Effect
Inhibition of adrenal corticotropic hormone 3X
FQPA (dog study) became an uncertainty factor
(E-mail from OPP; NOAEL - 0.12 mg/kg-day)








Related to Chronic Data - death



Notes
UF = 300; Basis NOAEL = 0.12 mg/kg-day








one year dog study; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
Volume(issue)/page/year2,1342,2001




Notes






Female Mouse
Negative
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-30

-------
 Dicofol
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                       EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
California Drinking Water Monitoring Data
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
T ' D I I t rTDh T t I
oxics e ease nven ory ( ) o a

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
21
17
35
Amount
Released
786,805
0
33
0
0
0
Units
Itas/yr
Ibs/yr
Ibs/yr

Amount
Range

Units
Ibs/yr
PWS
PWS
Sites
Number of
States
36
0
2

Date
2006
0%
0%
0%
Units
States
States
States



Date
1997
2004
2004





Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.









ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

1995-2007
Updated 201 3
Source
OPP

Value
180
BST
10,500
5.02

2.42E-07
0.8
4
Drinking water monitoring


Value Date
SW Chronic = 0.5 ug/L; GW Chronic = 0.069
ug/L

Units
days

L/kg
dimensionless
L/kg
atm-rrp/mol
mg/L
%
Notes

BST = Biodegrades sometimes/recalcitrant
(PBT)






                                                                                                                       Page A1-31

-------
Endosulfan
PCCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Endosulfan
5104
1 1 5297
Attribute Scores
Potency
5
Severity
6
Prevalence
10
Magnitude
7
Source
HSDB
Use
Insecticide
                                                                                                              3-Model Categorical Prediction
                                                                                                                          L?-L
                                                                                                                                                                                              Health Reference Level (HRL)1: 42 ug/L
                                                                                                                                                                                            Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                   HRL/Concentration Ratio(s)
                                                                                                                                                                                                  NCHRL/SW Chronic EEC:  28
                                                                                                                                                                                                             Status
                                                                                                                                                                                               CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
EPA OPP
IRIS
EPA HA
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA IRIS
EPA OPP
I ARC

Source
NTP
Value

0,006
0.006

0.002
0.006








Value



IN
E


Male Rat
Inadequate
Study
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'




Female Rat
Negative
Date

2007
1994

2000
1998








Date



1994
2007


Male Mouse
Inadequate
Study
Critical Effect

Reduced body weight gain, enlarged kidneys,
increased incidences of marked progressive
glomerulonephrosis; bloodvessel aneurysms in
males.
Reduced body weight gain in males and females,
increased incidence of marked progressive
glomerulonephrosis and blood vessel aneurysms
in males.

hepatic; liver








Notes

Basis NOAEL = 0.6 mg/kg-d; UF = 100 (rat study)
Hoechst, 1989a, Basis NOAEL = 0.7 mg/kg-d (female) and 0.6mg/kg-d (male); UF=100 (rat study)

Hoechst, 1989c, Basis NOAEL = 0.18 mg/kg-d, dog, UF=100









Notes







Female Mouse
Negative
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of UMD Yes teratogen list
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used i
  1 For the CCL process HRLs were calculated by
  2 Cancer classifications were only used for scree
n attribute scoring. Blank fields indicate there were no data available.
converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
;ning. For potency scoring quantitative cancer risk data were used.
                                                                                                                    Page A1-32

-------
 Endosulfan
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                       EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
T ' R I I t fTRh ^ f W
eease nven ory
Toxics Release Inventory (TRI) -Total
665
Amount
Released
1,601,195


105
Units
Itas/yr
Ibs/yr
Ibs/yr
Sites
Number of
States
44



Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
Amount
Range

Units
Ibs/yr
Date
2006
15.79%
Units
States
States
States

Date
1997
2010
2010

0.1

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.

0.01
0.01
ug/L | Updated 201 3
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
Source
OPP

Value
180
BST
22,000
3.83

6.51 E-05
0.45
4

Value Date
SW Chronic- 1 5 ug/L- GW Chronic - 0 012
ug/L

Units
days

L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
Notes

BST = Biodegrades sometimes/recalcitrant
(PBT)






                                                                                                                      Page A1-33

-------
Fluometuron
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Fluometuron
12839
21 641 72
Attribute Scores
Potency
5
Severity
3
Prevalence
9
Magnitude
5
Source
HSDB
Use
Herbicide
                                                                                                               3-Model Categorical Prediction
                                                                                                                           NL?
                                                                                                                                                                                              Health Reference Level (HRL)1: 38.5 ug/L
                                                                                                                                                                                           Health Reference Level (HRL)1 cancer: 1.94 ug/L
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                  NC HRL/NAWQA AW 90%: 19.25
                                                                                                                                                                                                  CAR HRL/NAWQA AW 90%: 0.97
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
EPA OPP
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0.0055
0.013
0.01
0.013





100




Value

0.018


C
3

Male Rat
Negative
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-1
(mg/kg-d)-1
(mg/kg-d)-1



Female Rat
Negative
Date

1987
1987
1987










Date




2005
1987

Male Mouse
Equivocal
Critical Effect
Decreased body weight gain and discoloration in
the spleen.
No adverse effects.







Endocrine - changes in spleen weight, Blood -
changes in spleen, Nutritional and Gross
Metabolic - weight loss or decreased weight gain




Notes







Female Mouse
Negative

Notes
Basis NOAEL = 0.55 mg/kg-day; UF = 100
NCI, 1980, NOAEL 12.5 mg/kg-d, rat, UF=1000







90-day oral study in rat; NTIS National Technical Information Service. (Springfield, VA 22161) Formerly
U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year PB80-217904




Other Supporting Data Source Value Units Notes
Is contaminant on list of EPA Yes
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA 0.5 mg/L
(DWEL)

  Note: Highlighted data indicate value was used i
  1 For the CCL process HRLs were calculated by
  2 Cancer classifications were only used for scree
n attribute scoring. Blank fields indicate there were no data available.
converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
;ning. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-34

-------
 Fluometuron
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                       EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
4,600

130

Sites
Sites
2.83%

0.003

37.77

0.22

2

8.34

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
STOrage and RETrieval (STORET)

Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)

Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
11
5
590
27
505
Number
225
312

Amount
Released
5,313,290
0
0
2
2
6
0
8
Number of
Detects
19
24

Units
Ibs/yr
Ibs/yr
Ibs/yr

Amount
Range

Units
Ibs/yr
Sites
Sites
Samples
PWS
Sites
PWSs/
Sites/
Samples
Samples
Samples

Number of
States
15
0
0

Date
2006
18.2%
40%
1%
0%
1.58%
Percent
with Detects
8.4%
7.7%

Units
States
States
States
0.002
0.002
0.0044

0
Minimum
Cone.
(Detects)



Date
1997
2010
2010

0.042
0.028
1.22

0
Maximum
Cone.
(Detects)
0.1
0.264

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
0.007
0.007
0.0139

0
Median
Cone.
(Detects)


0.007
0.007
0.699

0
75th
Percentile
(Detects


0.033
0.019
1.17

0
95th
Percentile
(Detects)
0.062
0.145
ug/L
ug/L
ug/L
ug/L
ug/L
Cone.
Units
ug/L
ug/L

Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water
2003-2009
2003-2009
1993-2007
1995-2007
Updated 201 3
Date
1999
1999

Source
OPP

Value

BST
363
2.42

1.8E-09
110
12
-inished
Raw
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206


Notes
Finished Water; Method 9060 (HPLC/MS)
Ambient Water; Method 9060 (HPLC/MS)

Value Date


Units Notes
length of time
BST = Biodegrades sometimes/recalcitrant
(BIODEG)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                      Page A1-35

-------
Linuron
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Linuron
6584
330552

Source
HSDB
Use
Herbicide
Attribute Scores
Potency
5
Severity
3
Prevalence
1
Magnitude
1
                                                                                                               3-Model Categorical Prediction
                                                                                                                            NL
                                                                                                                                                                                               Health Reference Level (HRL)1: 56 ug/L
                                                                                                                                                                                             Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                     NCHRL/NAWQA90%: 215
                                                                                                                                                                                                              Status
                                                                                                                                                                                                CCL 4 Universe: Yes     PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA IRIS
EPA OPP
I ARC

Source
NTP
Value
0,008
0.002

0.002





4.93




Value



C
C


Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'




Female Rat

Date
1995
1986







1975




Date



1989
1995


Male Mouse

Critical Effect
Decreased RBC count, hematocrit & hemoglobin
levels
Abnormal blood pigment

Abnormal blood pigment





Blood - changes in serum compos tion (e.g. TP,
bilirubin, cholesterol), Biochemica - Enzyme
inhibition, induction, or change in blood or tissue
levels - other Enzymes



Notes
Basis NOAEL = 0.77 mg/kg-day; UF = 100. du Pont, 1962.
du Pont, 1962; Bas s LEL 0.625 mg/kg-d, dog, UF=300. NOEL not established.

du Pont, 1962; Bas s LEL 0.625 mg/kg-d, dog, UF=300. NOEL not established.





31 -week oral study n rat; GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year 40(7), 46, 1975




Notes







Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of CACART Yes Developmental
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-36

-------
 Linuron
 PCCL 4 Contaminant Information Sheet
                                                                                                                       EPA-OGWDW
 OCCURRENCE DATA

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR 1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)
293



0



PWS
PWS
PWS
PWS
0%























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
7,142

105

Sites
Sites
1.47%

0.0005

1.4

0.03

0.26

0.74

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
Illinois Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total
142
13
7
323
312
228
225
512
42
1
753
592
Amount
Released
516,133
0
1
0
2
1
1
0
0
0
1
0
0
0
15
Units
Ibs/yr
Ibs/yr
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
Samples
Samples
PWS
PWS
Sites
Sites
Number of
States
35
0
1

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
Amount
Range
No Reports
Units
Ibs/yr
Date
2002
0%
15.4%
14.3%
0.3%
0%
0%
0%
0.2%
0%
0%
0%
2.53%
Units
States
States
States

0.0075
0.0042




0.0123



0
Date
1997
2010
2010


0.315
0.019
0.035



0.0123



3.5

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.

0.161
0.011




0.0123



0

0.284
0.017




0.0123



1.3

0.312
0.019




0.0123



3.3
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)
Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
1999
1999
1993-2007
1995-2007
1998-2005
2004-201 1
Updated 201 3
Source
OPP
Value
60
BST
350
3.2

6.26E-09
75
11
Drinking water monitoring
=inished
Raw
Ambient Water; Method 2001 (GC/MS)
Ambient Water; Method 9060 (HPLC/MS)
Finished Water; Method 2001 (GC/MS)
Finished Water; Method 9060 (HPLC/MS)
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206




Value

Units
days

L/kg
dimensionless
L/kg
atm-rrp/mol
mg/L
%
Date

Notes

BST = Biodegrades sometimes/recalcitrant
(PBT)






                                                                                                                      Page A1-37

-------
Malathion
PCCL 4 Contaminant Information Sheet
                                                                                                                      EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Malathion
5402
121755

Source
HSDB
Use
Insecticide; veterinary medicine
Attribute Scores
Potency
4
Severity
3
Prevalence
9
Magnitude
3
                                                                                                               3-Model Categorical Prediction
                                                                                                                            NL
                                                                                                                                                                                               Health Reference Level (HRL)1: 490 ug/L
                                                                                                                                                                                              Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                     HRL/Concentration Ratio(s)
                                                                                                                                                                                                    NC HRL/NAWQA 90%: 5,698
                                                                                                                                                                                                              Status
                                                                                                                                                                                                 CCL 4 Universe: Yes    PCCL 4: Yes     Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0,07
0.02
0.02
0.02
0.02
0.3



0.34




Value



Suggestive
3

Male Rat
Negative
Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-'



Female Rat
Negative
Date
2006
1987
1992
1987
2003
1997



2001




Date



2006


Male Mouse
Not Tested
Critical Effect
RBC cholinesterase inhibit on in pups
Red blood cell cholinesterase inhibition

RDBChE depression
cholinesterase inhibition




Blood - changes in serum compos tion (e.g. TP,
bilirubin, cholesterol), Biochemica - Enzyme
inhibition, induction, or change in blood or tissue
levels - true cholinesterase



Notes
Basis BMDL = 7.1 mg/kg-d; UF = 100 (rat study)
Moellerand Rider, 1962, basis NOEL 0.23 mg/kg-d, human, UF=10

Moellerand Rider, 1962, basis NOEL/LEL, human, UF=10
Daly, 1996, basis NOAEL 2 mg/kg-d, rat, UF=100




56-day oral study in human; HBPTO Handbook of pesticide toxicology. Robert Krieger ed, Academic press,
2001 Volume(issue)/page/year 1,59,2001




Notes






Female Mouse
Not Tested
Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of UMD Yes teratogen
reproductive toxins?
Drinking Water Equivalent Level EPA HA 0.8 mg/L Drinking Water Equivalent Level
(DWEL)
Maximum Acceptable Concentration CADW 0.19 mg/L Canadian Drinking Water Maximum Acceptable
(MAC) Concentration

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-38

-------
Malathion
PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                       EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)
7,117

344

Sites
Sites
4.83%

0.0015

9,58

0.0137

0.0863

0.394

ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Toccalinoetal., 2010
California Drinking Water Monitoring Data
USGS/California Groundwater Ambient
Monitoring and Assessment (GAMA) Program
STOrage and RETrieval (STORET)
Application/Release Data
National Center for Food and Agricultural Policy
(NCFAP) - Application
. /-rnl\ (T-

Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
271
7
13
323
228
898
58
1,828
1,491
Amount
Released
5,809,943
5
13,250

Amount
Range

0
0
2
6
0
0
0
0
178
Units
Ibs/yr
Ibs/yr
Ibs/yr

Units
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
PWS
Sites
Sites
Number of
States
42
1
7

Date
2006
0%
0%
15.4%
1.9%
0%
0%
0%
0%
11.94%
Units
States
States
States



0.01





0
Date
1997
2010
2010



0.331
0.106




3.43

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.


0.171





0.048


0.299





0.186


0.328





1.2
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
1993-2007
1995-2007
2004-201 1
Updated 201 3
Source
OPP

Value
11
DF
30.5
2.36

4.89E-09
143
25
Drinking water monitoring
Raw
=inished
Ambient Water; Method 2001 (GC/MS)
Finished Water; Method 2001 (GC/MS)
Ground water; Source Water; Toccalino et al., 2010, Quality of
source water from public-supply wells in the United States,
1993-2007: USGS Sci. Investigations Report 2010-5024, p. 206



Value Date


Units Notes
days
DF = Degrades fast (HSDB)
L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
                                                                                                                      Page A1-39

-------
Phosmet
PCCL 4 Contaminant Information Sheet
                                                                                                                     EPA-OGWDW
Contaminant:
Substance Key:
Contaminant ID (CASRN):
Phosmet
9544
732116

Source
HSDB
Use
Insecticide
Attribute Scores
Potency
6
Severity
3
Prevalence
1
Magnitude
1
                                                                                                              3-Model Categorical Prediction
                                                                                                                            NL
                                                                                                                                                                                               Health Reference Level (HRL)1: 42 ug/L
                                                                                                                                                                                             Health Reference Level (HRL)1 cancer: N/A
                                                                                                                                                                                                    HRL/Concentration Ratio(s)
                                                                                                                                                                                                      NC HRL/GWC EEC:  105
                                                                                                                                                                                                              Status
                                                                                                                                                                                                CCL 4 Universe: Yes    PCCL 4: Yes    Draft CCL 4: No
HEALTH EFFECTS DATA
Non-Cancer Data
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Reference Dose (RfD)
Minimal Risk Level
Acceptable Daily Intake (ADI)
Acceptable Daily Intake (ADI)
Tolerable Daily Intake (TDI)
No Observed Effect Level (NOEL)
Lowest Observed Adverse Effect Level (LOAEL)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)
Lethal Dose 50 (LD50)

Cancer Data
Lifetime Cancer Risk (10"-4)
Slope Factor (Oral)
Slope Factor (Oral)
Cancer Classification2
Cancer Classification2


Cancer Classification2
Source
EPA OPP
IRIS
EPA HA
RAIS HE
ATSDR
JMPR
CEDI ADI
ITER
CTD JPN
RTECS
HSDB
CTD JPN
RTECS

Source
EPA
OEHHA
RAIS HE
EPA OPP
I ARC

Source
NTP
Value
0,006
0.02

0.02

0.01






26

Value



Suggestive


Male Rat

Units
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg-d
mg/kg
mg/kg
mg/kg

Units
mg/L
(mg/kg-d)-'
(mg/kg-d)-1



Female Rat

Date
2010
1986

1986

1998






1969

Date



2010


Male Mouse

Critical Effect
RBC cholinesterase inhibit on (rat study)
Red. Body weight; liver cell vacuo zation; ChE
inhibition

Reduced bodywt; liver cell vacuolization;
Cholinerase inhibition








Behavioral - somnolence (general depressed
activity), Behavioral - muscle contraction or
spasticity, Lungs, Thorax, or Resp ration - dyspnea
Notes
Basis BlvlDL = 0.6 mg/kg-day. RfD is for general population.
Stauffer Chemical 1967; Basis NOEL 2 mg/kg-d, male rat, UF=100

Stauffer Chemical 1967; Basis NOEL/LEL, ma e rat, UF=101








HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71.
Discontinued. Volume(issue)/page/year 34(1 -3), 192, 1969

Notes






Female Mouse

Other Supporting Data Source Value Units Notes
Is contaminant on list of
carcinogens?
Is the contaminant on a list of
reproductive toxins?
Drinking Water Equivalent Level EPA HA mg/L
(DWEL)

  Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.
  1 For the CCL process HRLs were calculated by converting the RfD or other dose to ug/L, assuming 2 L/day of water consumed by a 70 Kg adult, and a Relative Source Contribution of 20%. For carcinogens, the concentration at the 10A-6 cancer risk was used.
  2 Cancer classifications were only used for screening. For potency scoring quantitative cancer risk data were used.
                                                                                                                     Page A1-40

-------
 Phosmet
 PCCL 4 Contaminant Information Sheet
 OCCURRENCE DATA
                                                                                                                     EPA-OGWDW

Number of
PWSs/Sites/
Samples
Number of
Detects
PWSs/
Sites/
Samples
Percent
with Detects
Minimum
Cone.
(Detects)
Maximum
Cone.
(Detects)
Median
Cone.
(Detects)
90th
Percentile
(Detects)
99th
Percentile
(Detects)
Cone.
Units
Date
Notes
Finished Water Data
Unregulated Contaminant Monitoring Rule
(UCMR1)
Unregulated Contaminant Monitoring (UCM)
Round 1
Unregulated Contaminant Monitoring (UCM)
Round 2
National Inorganics and Radionuclide Survey
(NIRS)








PWS
PWS
PWS
PWS
























ug/L
ug/L
ug/L
ug/L
2001-2003
1988-1992
1993-1997
1984-1986





Ambient Water Data
National Water-Quality Assessment Program
(NAWQA)
National Reconnaissance of Emerging
Contaminants (NREC)




Sites
Sites












ug/L
ug/L
1992-2001
1999-2004


Supplemental Water Data
California Department of Health Services
Pesticide Data Program (POP)
Pesticide Data Program (POP)
Pesticide Pilot Monitoring Program (PMP)
Pesticide Pilot Monitoring Program (PMP)
Hopple etal., 2009
Hopple etal., 2009
Hopple etal., 2009
California Drinking Water Monitoring Data
STOrage and RETrieval (STORET)

Application/Release Data
National Center for Food and Agricultural Policy

Toxics Release Inventory (TRI) - Surface Water
Toxics Release Inventory (TRI) -Total

Production
Chemical Update System/Inventory Update
Reporting (CUS/IUR)
11
13
6
317
221
34
211
34
2
700

Amount
Released
1,333,468


0
0
0
0
0



0
20

Units
Ibs/yr
Ibs/yr
Ibs/yr

Amount
Range

Units
Ibs/yr
PWS
Sites
Sites
Samples
Samples
Samples
Samples
Samples
PWS
Sites

Number of
States
40



Date
2006
0%
0%
0%
0%
0%
0%
0%
0%
0%
2.86%

Units
States
States
States









0

Date
1997
2010
2010










0.222

Note: Highlighted data indicate value was used in attribute scoring. Blank fields indicate there were no data available.









0









0.198









0.217
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L
ug/L

Other Supporting Data
Estimated Environmental Concentration (EEC)

Environmental Fate Parameters
Half Life
Degradation Code
Organic Carbon Partitioning Coefficient (Koc)
Log Octanol-water Partitioning Coefficient (Kow)
Distribution Coefficient (Kd)
Henry's Law Coefficient
Solubility in Water
Modeled Percent in Water

2003-2009
2003-2009
1999
1999
2002-2005
2002-2005
2002-2005
1995-2007
Updated 201 3

Source
OPP

Value
38
BSA
42.9
2.78

8.39E-09
24.4
41
Drinking water monitoring
rinished
Raw
Ambient Water; Method 9002 (GC/MS)
Finished Water; Method 9002 (GC/MS)
Ground water; Phase 2; Source water; Hopple etal., 2009,
Anthropogenic organic compounds in source water of selected
community water systems that use groundwater, 2002-05:
USGS Sci. Investigations Report 2009-5200, p. 74
Ground water; Phase 1; Source water; Hopple et
al., 2009
Ground water; Phase 2; Finished water; Hopple et al., 2009



Value
SW Chronic = N/A
GW Chronic = 0.4 ug/L
Date


Units
days

L/kg
dimensionless
L/kg
atm-nf/mol
mg/L
%
Notes

BSA = Biodegrades slow with acclimation
(PBT)






                                                                                                                    Page A1-41

-------
EPA OGWDW                  Contaminant Information Sheets
                                 for Microbes
        Appendix 2: Microbial Contaminant Information Sheets
                                Page A2 -1

-------
EPA OGWDW
Contaminant Information Sheets
        for Microbes
EPA 815-R-15-003
                                        Adenovirus Scoring Data
Scoring Summary1'2
Occurrence
3
Health Effects
General population
Sensitive subpopulation(s) [CD, C]
6
4
1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the
general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by
multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for
total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic
Disease
Score2

5
4
3
2
1

3
Data Element
Scoring Data
Reference3
Waterborne Disease Outbreaks
Has caused multiple (2 or
more) documented WBDOs
in the U.S. as reported by
CDC surveillance between
1990 and 2008
Has caused at least one
documented WBDOs in the
U.S. as reported by CDC
surveillance between 1990
and 2008
Has caused documented
WBDOs at any time in the
U.S.?
Has caused WBDOs in
countries other than the
U.S.?
Has never caused WBDOs in
any country, but has been
epidemiologically associated
with water related disease?
No
No
No
Yes
Europe
N/A
CDC, 1991 -CDC,
2011
CDC, 1991 -CDC,
2011

Kukkula et al., 1997

Occurrence
Detected in drinking water
in the U.S.?
Yes
PCR in connection with
an outbreak.
O'Reilly et al., 2007
Fong et al., 2007
                                                  Page A2 - 2

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
                                                                              EPA 815-R-15-003
Score2

2


1

7

6[G]


5
4[C,
CD]

3
Data Element
Detected in source water in
the U.S.?



Not detected in the U.S.?
Scoring Data
Yes
38% of surface water
samples collected as part
of the Information
Collection Rule contained
Adenovirus 40/41.
N/A
Reference3
USEPA, 2007




Health Effects
Does the organism cause
significant mortality (>
1/1,000 cases)?
Does the organism cause
pneumonia, meningitis,
hepatitis, encephalitis,
endocarditis, cancer, or
other severe manifestations
of illness necessitating long
term hospitalization (>
week)?


Does the illness result in
long term or permanent
dysfunction or disability, i.e.
sequelae?
Does the illness require
short term hospitalization
(< week)?

Does the illness require
physician intervention?

[G] A frequent cause of
pneumonia among
(unvaccinated) military
recruits. Two deaths in
previously-healthy
adults.
ARD is still a significant
problem in military.
Less common
manifestations include
fatal neonatal disease,
meningoencephalitis and
myocarditis.
None reported
[CD] Children with
chronic disease required
respiratory ventilation.
[C] Young adults may
contract acute
respiratory disease.
Physician office visits are
indicated for ocular
infections.

Gray et al., 2001
Robinson in
Murray, 2010



CDC, 1983
CDC, 1998

Robinson in Murray,
2010
                                          Page A2 - 3

-------
EPA OGWDW
                        Contaminant Information Sheets
                               for Microbes
                                  EPA 815-R-15-003
 Score2
       Data Element
      Scoring Data
Reference3
2 [E, P]
Is the illness self-limiting
within 72 hours (without
requiring medical
intervention)?
[E, P] Approximately 50%
of cases are asymptomatic,
symptomatic cases usually
present as upper
respiratory infections
similar to the common
cold.
                                                                   Robinson in Murray,
                                                                   2010
          Does the illness result in
          mild symptoms with minimal
          or no impact on daily
          activities?
1 Bolded Text indicates the highest score for that particular protocol.  For the health effects protocol two
scores were selected: the general population [G] and the highest score for a sensitive subpopulation.
These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The
higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation.
Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease.
2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final.
August 2009 for a detailed description on how to calculate the total pathogen score.
3EPA based the WBDO scores on the CDC MMWR reports from 1991 - 2008 and then collected
occurrence citations if there were no CDC WBDOs.
References
CDC, 1983. Adenovirus type 7 outbreak in a pediatric chronic-care facility - Pennsylvania.
1972. MMWR, 1983:32;258-60.

CDC, 1998. Civilian Outbreak of Adenovirus Acute Respiratory Disease - South Dakota, 1997.
MMWR 1998:  47(27);567-570.

CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19891990. MMWR Surveillance Summaries, 40(SS-3); 1-21.

CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19911992. MMWR Surveillance Summaries, 42(SS-5); 1-22.

CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19931994. MMWR Surveillance Summaries, 45(SS-1); 1-33.

CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19951996. MMWR Surveillance Summaries, 47(SS-5); 1-33.

CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19971998. MMWR Surveillance Summaries, 49(SS-4); 1-35.
                                        Page A2 - 4

-------
EPA OGWDW                       Contaminant Information Sheets             EPA 815-R-15-003
                                         for Microbes
CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19992000. MMWR Surveillance Summaries, 51(SS-8); 1-36.

CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 20012002. MMWR Surveillance Summaries, 53(SS08); 23-45.

CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 20032004. MMWR Surveillance Summaries, 55(SS12); 31-58.

CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water and Water not Intended for Drinking  United States, 2005-2006. MMWR 57 (SS-9); 1-
72 (Table 4, p. 45; Table 5 p. 46).

CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46).

Fong, T., L. Mansfield, D. Wilson, D. Schwab, S Molloy and J Rose. 2007. Massive
Microbiological Groundwater Contamination Associated with a Waterborne Outbreak in Lake
Erie, South Bass Island, OH. Environmental Health Perspectives.

Gray, G C, P R Goswami, M D Malasig, A W Hawksworth, D H Trump, M A Ryan and D P
Schnurr.  2001. Adult Adenovirus Infections: Loss of Orphaned Vaccines Precipitates Military
Respiratory Disease Epidemics.  Clinical Infectious Diseases, 31: 663-70.
Kukkula, M., Arstila P., Klossner M.L., Maunula L., Bonsdorff C.H., and P. Jaatinen.  1997.
Waterborne outbreak of viral gastroenteritis.  Scandinavian Journal of Infectious Disease, 29(4):
415-8.
O'Reilly, C.E., A.B. Bowen, E.P. Nytzia,  J.P. Sarisky, C.A. Shepherd, M.D. Miller,
B.C. Hubbard, M. Herring, S.D. Buchanan, C.C. Fitzgerald, V. Hill, MJ. Arrowood, L.X. Xiao,
R.M. Hoekstra, E.D. Mintz, M.F. Lynch, and the Outbreak Working Group. 2007.  A
Waterborne Outbreak of Gastroenteritis with Multiple Etiologies among Resort Island Visitors
and Residents: Ohio, 2004. Clinical Infectious Diseases, 44:506-512.
http://www.journals.uchicago.edu/CID/journal/issues/v44n4/40825/40825.text.html -
fnl#fnlhttp://wwwjournals.uchicago.edu/CID/journal/issues/v44n4/40825/40825.text.html -
fn2#fn2
Robinson, C. and M. Echavarria. 2010. Adenoviruses. In Murray, P. R., E. J. Baron, J. H.
Jorgensen, M.L. Landry, and M. A. Pfaller (ed.) The Manual of Clinical Microbiology, 10th.
edition, American Society for Microbiology, Washington, DC. Vol. 2: p. 1600.
USEPA.  2007. Adenovirus Health and Criteria Document (Draft).
                                       Page A2 - 5

-------
EPA OGWDW
Contaminant Information Sheets
        for Microbes
                                                                                           EPA 815-R-15-003
                                     Naegleria fowleri Scoring Data
Scoring Summary1'2
Waterborne Disease Outbreak
4
Health Effects
General population
Sensitive subpopulation(s) [C, P, E, CD]
7
7
1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the
general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by
multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for
total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic
Disease
Score2

5
4
3
2
1
Data Element
Scoring Data
Reference3
Waterborne Disease Outbreaks
Has caused multiple (2 or
more) documented WBDOs
in the U.S. as reported by
CDC surveillance between
1990 and 2008?
Has caused at least one
documented WBDOs in the
U.S. as reported by CDC
surveillance between 1990
and 2008?
Has caused documented
WBDOs at any time in the
U.S.?
Has caused WBDOs in
countries other than the
U.S.?
Has never caused WBDOs in
any country, but has been
epidemiologically associated
with water related disease?
No
Yes
1 Community
N/A
N/A
N/A
CDC, 1991 -CDC,
2011
CDC, 2004



                                                  Page A2 - 6

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
EPA 815-R-15-003
Score2

3
2
1

7[G,C,P,
E,CD]
6
5
4
O
2
Data Element
Scoring Data
Reference3
Occurrence
Detected in drinking water
in the U.S.?
Detected in source water in
the U.S.?
Not detected in the U.S.?
Yes
Arizona storage -
Sampled pre-treatment
multiple-well study in
Arizona.
Yes
N/A
Gerba et al., 2007
Marciano-Cabral et
al., 2003
Schuster and
Visvesvara, 2004

Health Effects
Does the organism cause
significant mortality (>
1/1,000 cases)?
Does the organism cause
pneumonia, meningitis,
hepatitis, encephalitis,
endocarditis, cancer, or other
severe manifestations of
illness necessitating long
term hospitalization (>
week)?
Does the illness result in
long term or permanent
dysfunction or disability, i.e.
sequelae?
Does the illness require short
term hospitalization (<
week)?
Does the illness require
physician intervention?
Is the illness self-limiting
within 72 hours (without
requiring medical
intervention)?
[All populations]
Recovery from primary
amoebic
meningoencephalitis is
rare.
Acute fulminating
disease. Only a few
patients have survived.
No
All cases are hospitalized
for diagnosis and
treatment.


Heymann, 2005
Visvesvara in
Murray, 2010

Visvesvara in
Murray, 2010


                                          Page A2 - 7

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
                                                                           EPA 815-R-15-003
Score2
1
Data Element
Does the illness result in
mild symptoms with
minimal or no impact on
daily activities?
Scoring Data

Reference3

1 Bolded Text indicates the highest score for that particular protocol.  For the health effects protocol two
scores were selected: the general population [G] and the highest score for a sensitive subpopulation.
These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The
higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation.
Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease.
2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final.
August 2009 for a detailed description on how to calculate the total pathogen score.
3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected
occurrence citations if there were no CDC WBDOs.

References
CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19891990. MMWR Surveillance Summaries, 40(SS-3); 1-21.

CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19911992. MMWR Surveillance Summaries, 42(SS-5); 1-22.

CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19931994. MMWR Surveillance Summaries, 45(SS-1); 1-33.

CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19951996. MMWR Surveillance Summaries, 47(SS-5); 1-33.

CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19971998. MMWR Surveillance Summaries, 49(SS-4); 1-35.

CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19992000. MMWR Surveillance Summaries, 51(SS-8); 1-36.

CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 20012002. MMWR Surveillance Summaries, 53(SS08); 23-45.

CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 2003 2004. MMWR Surveillance Summaries, 55(SS12); 31-58.

CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water and Water not Intended for Drinking  United States, 2005-2006. MMWR 57 (SS-9); 1-
72 (Table 4, p. 45; Table 5 p. 46).

                                        Page A2 - 8

-------
EPA OGWDW                       Contaminant Information Sheets             EPA 815-R-15-003
                                         for Microbes
CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46).

Gerba, C.,  B. Blair, P.  Sarkar, and K.  Bright.  2007.  Occurrence and  Control of Naegleria
fowleri  in  Well Water and  Chlorine  Resistance.  Proceedings, Water Quality  Technology
Conference, American Water Works Association, November 5-8, 2007.
Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual, 18th ed. American Public
Health Association, Washington, DC. pp. 417-419.
Marciano-Cabral, F., R. MacLean, A.  Mensah, and L. LaPat-Polasko. 2003. Identification of
Naegleria fowleri in domestic water source by nested PCR. Appl. Environ. Microbiol. 69 (10):
5864-5869.

Schuster, F.L. and G.S. Visvesvara. 2004. Free-living amoebae as opportunistic and non-
opportunistic pathogens of humans and animals. Int. J. Parasitol. 34: 1001-1027.
Visvesvara, G. 2007. Pathogenic and Opportunistic Free-Living Amebae.   In Murray, P. R., E.
J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H Yolken (ed.) The Manual of Clinical
Microbiology, 10th edition, American Society for Microbiology, Washington, DC Vol. 2;  pp.
3129.
                                       Page A2 - 9

-------
EPA OGWDW
Contaminant Information Sheets
        for Microbes
EPA 815-R-15-003
                                    Toxoplasma gondii Scoring Data
Scoring Summary1'2
Waterborne Disease Outbreak
2
Health Effects
General population
Sensitive subpopulation(s) [P]
2
7
1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two scores were selected: the
general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by
multiplying by 5/14 for a final health effects score. The higher score between the WBDO and Occurrence protocols was used for
total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic
Disease
Score2

5
4
3
2
1
Data Element
Scoring Data
Reference3
Waterborne Disease Outbreaks
Has caused multiple (2
or more) documented
WBDOsintheU.S. as
reported by CDC
surveillance between
1990 and 2008?
Has caused at least one
documented WBDOs in
the U.S. as reported by
CDC surveillance
between 1990 and
2008?
Has caused documented
WBDOs at any time in
the U.S.?
Has caused WBDOs
in countries other
than the U.S.?
Has never caused
WBDOs in any
country, but has been
epi demi ol ogi cally
associated with water
related disease?
No
No
No
Yes
Canada and Brazil.
N/A
CDC, 1991 -CDC,
2011
CDC, 1991 -CDC,
2011

Bowie et al., 1997
de Moura, 2006

                                                 Page A2 - 10

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
                                                                              EPA 815-R-15-003
Score2

3


2


1








7[P]










6







5


Data Element
Scoring Data
Reference3
Occurrence
Detected in drinking
water in the U.S.?
Detected in source

water in the U.S.?
Not detected in the
U.S.?

No

No


Yes
Groundwater in Poland
and Canada.





Sroka et al., 2006
Isaac-Renton et al.,
1998
Health Effects
Does the organism
cause significant
mortality (> 1/1,000
cases)?








Does the organism
cause pneumonia,
meningitis, hepatitis,
encephalitis,
endocarditis, cancer, or
other severe
manifestations of
illness necessitating
long term
hospitalization (>
week)?
Does the illness result
in long term or
permanent dysfunction
or disability, i.e.
sequelae?
[P] Congenital infection
of neonates severe.

Infection during early
pregnancy may lead to
fetal infection with death
of the fetus or other
severe manifestations.
Later in pregnancy,
maternal infection
results in mild or
subclinical fetal disease.
Immunocompromi sed
hosts may experience
CNS, pneumonitis, and
myocarditis.












Wilson in Murray,
2010

Heymann, 2005








Wilson in Murray,
2010














                                         PageA2- 11

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
                                                                             EPA 815-R-15-003
Score2
4
3
2 [G, C,
E, CD]
1
Data Element
Does the illness require
short term
hospitalization (<
week)?
Does the illness require
physician intervention?
Is the illness self-
limiting within 72
hours (without
requiring medical
intervention)?
Does the illness result
in mild symptoms with
minimal or no impact
on daily activities?
Scoring Data

Treatment is indicated
only for pregnant women,
infants and
immunocompromi sed
hosts.
[G, C, E, CD] Infection
is generally
asymptomatic; however
10 -20% of patients
with acute infection may
develop cervical
lymphadenopathy
and/or flu-like
symptoms.

Reference3

Wilson in Murray,
2010
Wilson in Murray,
2010

1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two
scores were selected: the general population [G] and the highest score for a sensitive subpopulation.
These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The
higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation.
Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease.
2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final.
August 2009 for a detailed description on how to calculate the total pathogen score.
3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected
occurrence citations if there were no CDC WBDOs.
References
Bowie, W. R., S. A. King, D. H. Werker, J. L. Isaac-Renton, A. Bell, S. B. Eng, and S. A.
Marion. 1997. Outbreak of toxoplasmosis associated with municipal drinking water. Lancet 350:
173-177.

CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19891990. MMWR Surveillance Summaries, 40(SS-3); 1-21.

CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
                                         Page A2 -  12

-------
EPA OGWDW                       Contaminant Information Sheets             EPA 815-R-15-003
                                        for Microbes
United States, 19911992. MMWR Surveillance Summaries, 42(SS-5); 1-22.

CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19931994. MMWR Surveillance Summaries, 45(SS-1); 1-33.

CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19951996. MMWR Surveillance Summaries, 47(SS-5); 1-33.

CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19971998. MMWR Surveillance Summaries, 49(SS-4); 1-35.

CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19992000. MMWR Surveillance Summaries, 51(SS-8); 1-36.

CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 2001 2002. MMWR Surveillance Summaries, 53(SS08); 23-45.

CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 2003 2004. MMWR Surveillance Summaries, 55(SS12); 31-58.

CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water and Water not Intended for Drinking  United States, 2005-2006. MMWR 57 (SS-9); 1-
72 (Table 4, p. 45; Table 5 p. 46).

CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46).

Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual, 18th ed. American Public
Health Association, Washington, DC.

Isaac-Renton, J, W.R. Bowie, A. King, G.S. Irwin, C.S. Ong, C.P. Fung, M.O. Shokeir and J.P.
Dubey.  1998.  Detection of Toxoplasma gondii Oocysts in Drinking Water. Appl. Environ.
Microbiol. 64(6): 2278-2280.

de Moura L., L.M. Bahia-Oliveira, M.Y. Wada, J.L. Jones, S.H. Tuboi, E.H. Carmo, W.M.
Ramalho, N.J. Camargo, R. Trevisan, R.M. Graca, AJ. da Silva, I. Moura, J.P. Dubey, and D.O.
Garrett. 2006. Waterborne toxoplasmosis, Brazil, from field to gene. Emerging Infectious
Diseases, 12(2): 326-9.

Sroka J., A. Wojcik-Fatla, J. Dutkiewicz. 2006. Occurrence of Toxoplasma Gondii in Water
from Wells Located on Farms. Ann Agric Environm Med. 13: 169-175.

Jones, J., J. McAuley and K. Singh. 2010. Toxoplasma. In Murray, P. R., E. J. Baron, J. H.
Jorgensen, M.L. Landry, and M. A. Pfaller (ed.) The Manual of Clinical Microbiology, 10th.
edition, American Society for Microbiology, Washington, DC. Vol. 2: p. 2127.
                                       Page A2 - 13

-------
EPA OGWDW
Contaminant Information Sheets
         for Microbes
EPA 815-R-15-003
                                       Vibrio cholerae Scoring Data
Scoring Summary1'2
Waterborne Disease Outbreak
4
Health Effects
General population
Sensitive subpopulation(s) [C, E, P,
CD]
3
3
1 Bolded Text indicates the highest score for that particular protocol.  For the health effects protocol two scores were selected: the
general population [G] and the highest score for a sensitive subpopulation. These 2 scores were added and normalized by
multiplying by 5/14 for a final health effects score.  The higher score between the WBDO and Occurrence protocols was used for
total pathogen score calculation. Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic
Disease
Score2

5
4
3
2
1

3
Data Element
Scoring Data
Reference3
Waterborne Disease Outbreaks
Has caused multiple (2 or
more) documented WBDOs
in the U.S. as reported by
CDC surveillance between
1990 and 2008?
Has caused at least one
documented WBDOs in the
U.S. as reported by CDC
surveillance between 1990
and 2008?
Has caused documented
WBDOs at any time in the
U.S.?
Has caused WBDOs in
countries other than the U.S.?
Has never caused WBDOs in
any country, but has been
epidemiologically associated
with water related disease?
No
1 Community
N/A
N/A
N/A
CDC, 1991 -CDC,
2011
CDC, 1996



Occurrence
Detected in drinking water
in the U.S.?
Yes (outbreak data)
CDC, 1996
                                                  Page A2 - 14

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
EPA 815-R-15-003
Score2
2

1



7










6







5


Data Element
Detected in source water in
the U.S.?
Not detected in the U.S.?
Scoring Data
Yes

N/A
Reference3
Rhodes et al., 1986
Kaperetal., 1982

Health Effects
Does the organism cause
significant mortality (>
1/1,000 cases)?


Does the organism cause
pneumonia, meningitis,
hepatitis, encephalitis,
endocarditis, cancer, or other
severe manifestations of
illness necessitating long term
hospitalization (> week)?









Does the illness result in long
term or permanent
dysfunction or disability, i.e.
sequelae?
V. cholerae Non-Ol :
third most commonly
isolated in U.S. -
Septicemia case fatality
rate from 24-65%.
V. cholerae Ol:
Extremely rare cases
causes severe
extraintestinal infection.
If untreated, V. cholerae
Ol infection causes
severe dehydration which
leads to hypovolemic
shock, acidosis,
circulatory collapse, and
death. Unlike Ol strains,
non-Ol isolates are
commonly associated
with extrainstestinal
infections such as
septicemia.



Abbott in Murray,
2010



Abbott in Murray,
2010

















                                          Page A2 - 15

-------
EPA OGWDW
Contaminant Information Sheets
       for Microbes
EPA 815-R-15-003
Score2
4
3 [G, C,
P, E, CD]
2
1
Data Element
Does the illness require short
term hospitalization (<
week)?
Does the illness require
physician intervention?
Is the illness self-limiting
within 72 hours (without
requiring medical
intervention)?
Does the illness result in mild
symptoms with minimal or no
impact on daily activities?
Scoring Data
In severely dehydrated
cases (cholera gravis),
death may occur within a
few hours, and the case-
fatality rate may exceed
50%. With proper and
timely rehydration, this
can be less than 1%.
[All populations] In
most cases infection is
asymptomatic or causes
self-limiting diarrhea.
Treatment consists of
fluid replacement by
oral rehydration
therapy and/or
intravenous fluids.


Reference3
Heymann, 2005
Abbott in Murray,
2010


1 Bolded Text indicates the highest score for that particular protocol. For the health effects protocol two
scores were selected: the general population [G] and the highest score for a sensitive subpopulation.
These 2 scores were added and normalized by multiplying by 5/14 for a final health effects score. The
higher score between the WBDO and Occurrence protocols was used for total pathogen score calculation.
Health Effects protocol: G - General, C - Child, E-Elderly, P - Pregnant Women, CD -Chronic Disease.
2See Final Contaminant Candidate List 3 Microbes: PCCL to CCL Process. EPA 815-R-09-009. Final.
August 2009 for a detailed description on how to calculate the total pathogen score.
3EPA based the WBDO scores on the CDC MMWR reports from 1991-2008 and then collected
occurrence citations if there were no CDC WBDOs.

References
Abbott, S. L., J. M. Janda, and J. J. Farmer.  2010.  Vibrio and Related Organisms.  In Murray, P.
R., E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H Yolken (ed.) The Manual of Clinical
Microbiology, 8th. edition, American Society for Microbiology, Washington, DC.  Vol. 1: pp.
666.

CDC, 1991. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
                                         Page A2 - 16

-------
EPA OGWDW                       Contaminant Information Sheets             EPA 815-R-15-003
                                         for Microbes
United States, 19891990. MMWR Surveillance Summaries, 40(SS-3); 1-21.

CDC, 1993. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19911992. MMWR Surveillance Summaries, 42(SS-5); 1-22.

CDC, 1996. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19931994. MMWR Surveillance Summaries, 45(SS-1); 1-33.

CDC, 1998. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19951996. MMWR Surveillance Summaries, 47(SS-5); 1-33.

CDC, 2000. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19971998. MMWR Surveillance Summaries, 49(SS-4); 1-35.

CDC, 2002. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 19992000. MMWR Surveillance Summaries, 51(SS-8); 1-36.

CDC, 2004. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 20012002. MMWR Surveillance Summaries, 53(SS08); 23-45.

CDC, 2006. Surveillance for Waterborne-Disease Outbreaks Associated with Drinking Water 
United States, 20032004. MMWR Surveillance Summaries, 55(SS12); 31-58.

CDC. 2008. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water and Water not Intended for Drinking  United States, 2005-2006. MMWR 57 (SS-9); 1-
72 (Table 4, p. 45; Table 5 p. 46).

CDC. 2011. Surveillance for Waterborne Disease and Outbreaks Associated with Drinking
Water - United States, 2007-2008. MMWR 60 (SS-12); 1-80 (Table 4, p. 45; Table 5 p. 46).


Heymann, D. (ed.). 2005. Control of Communicable Diseases Manual,  18th ed. American Public
Health Association, Washington, DC. pp. 113-127.

Kaper, J. B., H. B. Bradford, N. C. Roberts, and S. Falkow.  1982. Molecular epidemiology of
Vibrio cholerae in the U.S. Gulf Coast. J. Clin. Microbiol. 16(1): 129-134.

Rhodes, J.B., H.L. Smith Jr., and I.E.  Ogg.  1986. Isolation of Non-Ol Vibrio cholerae Serovars
from Surface Waters in Western Colorado.  Appl. Environ. Microbiol. 51(6): 1216-1219.
                                       Page A2 - 17

-------