19 November 2008 Page 1
Preliminary Reference List for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD):
In Vivo Mammalian Dose-Response and Epidemiological Studies
't Mannetje, A., D. McLean, S. Cheng, P. Boffetta, D. Colin and N. Pearce. 2005.
Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins. Occup.
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Abadin, H.G., C.H. Chou and FT. Llados. 2007. Health effects classification and its
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Abbott, B.D., T.M. Lin, NT. Rasmussen, R.M. Albrecht, J.E. Schmid and R.E. Peterson.
2003. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of
prostatic epithelial buds and influences the response to TCDD. Toxicol. Sci.
76(2):427-436.
Abraham, K., A. Geusau, Y. Tosun, H. Helge, S. Bauer and J. Brockmoller. 2002.
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the
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Adamsson, A., U. Simanainen, M. Viluksela, J. Paranko and J. Toppari. 2008. The
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Alaluusua, S., P. Calderara, P.M. Gerthoux, P.L. Lukinmaa, 0. Kovero, L. Needham,
D.G. Patterson, Jr., J. Tuomisto and P. Mocarelli. 2004. Developmental dental
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Allen, D.E. and L.J. Leamy. 2001. 2,3,7,8-tetrachlorodibenzo-p-dioxin affects size and
shape, but not asymmetry, of mandibles in mice. Ecotoxicology. 10(3): 167-1 76.
Alsharif, N.Z. and E.A. Hassoun. 2004. Protective effects of vitamin A and vitamin E
succinate against 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting,
hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage
in C57BL/6J mice. Basic Clin. Pharmacol. Toxicol. 95(3): 131 -138.
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Ambrus, J.L., A. Islam, S. Akhter, W. Dembinski, M. Kulaylat and C.M. Ambrus. 2004.
Multiple medical problems following agent orange exposure. J. Med. 35(1-6):265-269.
Amin, S., R.W. Moore, R.E. Peterson and S.L. Schantz. 2000. Gestational and
lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin
preference behavior in female rats. Neurotoxicol. Teratol. 22(5):675-682.
Anger, D.L. and W.G. Foster. 2008. The link between environmental toxicant exposure
and endometriosis. Front Biosci. 13:1578-1593.
Aragon, A.C., M.B. Goens, E. Carbett and M.K. Walker. 2008a. Perinatal
2,3,7,8-tetrachlorodibenzo-p-dioxin exposure sensitizes offspring to angiotensin
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Aragon, A.C., P.G. Kopf, M.J. Campen, J.K. Huwe and M.K. Walker. 2008b. In utero
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Arisawa, K., H. Takeda and H. Mikasa. 2005. Background exposure to
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Atallah, E. and C.A. Schiffer. 2007. Agent Orange, prostate cancer irradiation and
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Aulerich, R.J., B. Yamini and S.J. Bursian. 2001. Dietary exposure to
3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-p-dixon (TCDD)
does not induce proliferation of squamous epithelium or osteolysis in the jaws of
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Baccarelli, A., A.C. Pesatori, S.A. Masten, D.G. Patterson, Jr., L.L. Needham, P.
Mocarelli, N.E. Caporaso, D. Consonni, J.A. Grassman, P.A. Bertazzi and M.T. Landi.
2004. Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in
humans: a population-based study in Seveso, Italy. Toxicol. Lett. 149(1-3):287-293.
Baccarelli, A., A.C. Pesatori, D. Consonni, P. Mocarelli, D.G. Patterson, Jr., N.E.
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Baccarelli, A., C. Hirt, A.C. Pesatori, D. Consonni, D.G. Patterson, Jr., P.A. Bertazzi, G.
Dolken and M.T. Landi. 2006. t(14;18) translocations in lymphocytes of healthy
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Baccarelli, A., S.M. Giacomini, C. Corbetta, M.T. Landi, M. Bonzini, D. Consonni, P.
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Badawi, A.F., E.L. Cavalieri and E.G. Rogan. 2000. Effect of chlorinated hydrocarbons
on expression of cytochrome P450 1A1, 1A2 and 1B1 and 2- and 4-hydroxylation of
17beta-estradiol in female Sprague-Dawley rats. Carcinogenesis. 21 (8): 1593-1599.
Bagchi, D., J. Balmoori, M. Bagchi, X. Ye, C.B. Williams and S.J. Stohs. 2002.
Comparative effects of TCDD, endrin, naphthalene and chromium (VI) on oxidative
stress and tissue damage in the liver and brain tissues of mice. Toxicology.
175(1-3):73-82.
Barrett, D.H., R.D. Morris, F.Z. Akhtarand J.E. Michalek. 2001. Serum dioxin and
cognitive functioning among veterans of Operation Ranch Hand. Neurotoxicology.
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Bell, D.R., S. Clode, M.Q. Fan, A. Fernandes, P.M. Foster, T. Jiang, G. Loizou, A.
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2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No
decrease in epididymal sperm count after a single acute dose. Toxicol. Sci.
99(1 ):214-223.
Bell, D.R., S. Clode, M.Q. Fan, A. Fernandes, P.M. Foster, T. Jiang, G. Loizou, A.
MacNicoll, B.C. Miller, M. Rose, L. Iran and S. White. 2007b. Relationships between
tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the
developing male Wistar(Han) rat. Toxicol. Sci. 99(2):591-604.
Bell, D.R., S. Clode, M.Q. Fan, A. Fernandes, P.M. Foster, T. Jiang, G. Loizou, A.
MacNicoll, B.C. Miller, M. Rose, L. Tran and S. White. 2007c. Toxicity of
2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic
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Bemis, J.C., N.F. Alejandro, D.A. Nazarenko, A.I. Brooks, R.B. Baggs and T.A.
Gasiewicz. 2007. TCDD-induced alterations in gene expression profiles of the
developing mouse paw do not influence morphological differentiation of this potential
target tissue. Toxicol. Sci. 95(1):240-248.
Besteman, E.G., K.L. Zimmerman and S.D. Holladay. 2005.
Tetrachlorodibenzo-p-Dioxin (TCDD) Inhibits Differentiation and Increases Apoptotic
Cell Death of Precursor T-Cells in the Fetal Mouse Thymus. J. Immunotoxicol.
2(2): 107-114.
Besteman, E.G., K.L. Zimmerman, W.R. Huckle, M.R. Prater, R.M. Gogal, Jr. and S.D.
Holladay. 2007. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or diethylstilbestrol (DES)
cause similar hematopoietic hypocellularity and hepatocellular changes in murine fetal
liver, but differentially affect gene expression. Toxicol. Pathol. 35(6):788-794.
Birnbaum, L.S. and J. Tuomisto. 2000. Non-carcinogenic effects of TCDD in animals.
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Birnbaum, L.S. and S.E. Fenton. 2003. Cancer and developmental exposure to
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Boersma, E.R. and C.I. Lanting. 2000. Environmental exposure to polychlorinated
biphenyls (PCBs) and dioxins. Consequences for longterm neurological and cognitive
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Boffetta, P. 2006. Human cancer from environmental pollutants: the epidemiological
evidence. Mutat. Res. 608(2): 157-162.
Bohn, A.A., K.S. Harrod, S. Teske and B.P. Lawrence. 2005. Increased mortality
associated with TCDD exposure in mice infected with influenza A virus is not due to
severity of lung injury or alterations in Clara cell protein content. Chem. Biol. Interact.
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Boverhof, D.R., L.D. Burgoon, C. Tashiro, B. Chittim, J.R. Harkema, D.B. Jump and
T.R. Zacharewski. 2005. Temporal and dose-dependent hepatic gene expression
patterns in mice provide new insights into TCDD-Mediated hepatotoxicity. Toxicol. Sci.
85(2): 1048-1063.
Bowers, O.J., K.B. Sommersted, R.T. Sowell, G.E. Boling, W.H. Hanneman, R.G. Titus
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Leishmania major burdens in C57BL/6 mice. Am. J. Trop. Med. Hyg. 75(4):749-752.
Boyle, S.H., W.G. Jackson and E.G. Suarez. 2007. Hostility, anger, and depression
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Brody, J.G., K.B. Moysich, 0. Humblet, K.R. Attfield, G.P. Beehler and R.A. Rudel.
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Brouillette, J. and R. Quirion. 2008. The common environmental pollutant
dioxin-induced memory deficits by altering estrogen pathways and a major route of
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Bruner-Tran, K.L., G.R. Yeaman, M.A. Crispens, T.M. Igarashi and K.G. Osteen. 2008.
Dioxin may promote inflammation-related development of endometriosis. Fertil. Steril.
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Brunnberg, S., P. Andersson, M. Lindstam, I. Paulson, L. Poellingerand A. Hanberg.
2006. The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for
dioxin exposure-effects in vital organs. Toxicology. 224(3): 191-201.
Buchanan, D.L., S. Ohsako, C. Tohyama, P.S. Cooke and T. Iguchi. 2002. Dioxin
inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in
cyclin and transforming growth factor-beta expression. Toxicol. Sci. 66(1):62-68.
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Byers, J.P., K. Masters, J.G. Sarverand E.A. Hassoun. 2006. Association between the
levels of biogenic amines and superoxide anion production in brain regions of rats after
subchronic exposure to TCDD. Toxicology. 228(2-3):291-298.
Calkosinski, I., M. Dobrzynski, M. Cegielski, A. Sieja and M. Calkosinska. 2006. [The
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Calle, E.E., H. Frumkin, S.J. Henley, D.A. Savitz and M.J. Thun. 2002.
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Camacho, I.A., M.R. Hassuneh, M. Nagarkatti and P.S. Nagarkatti. 2001. Enhanced
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Camacho, I.A., M. Nagarkatti and P.S. Nagarkatti. 2004a. Evidence for induction of
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Camacho, I.A., M. Nagarkatti and P.S. Nagarkatti. 2004b. Effect of
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on maternal immune response during
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Cao, Y., G. Winneke, M. Wilhelm, J. Wittsiepe, F. Lemm, P. Furst, U. Ranft, M. Imohl,
M. Kraft, B. Oesch-Bartlomowicz and U. Kramer. 2008. Environmental exposure to
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Casey, B. 2005. Environmental contaminants and maternal thyroid function. Am. J.
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Chao, H.R., S.L. Wang, L.Y. Lin, W.J. Lee and 0. Papke. 2007. Placental transfer of
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Charnley, G. and R.D. Kimbrough. 2006. Overview of exposure, toxicity, and risks to
children from current levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related
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Chaudhuri, A. and M.D. Harris. 2003. 'Proximal-type' epithelioid sarcoma: is Agent
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Chen, J., L.S. Laughlin, A.G. Hendrickx, K. Natarajan, J.W. Overstreet and B.L. Lasley.
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Chen, H.L., H.J. Su, Y.J. Wang, Y.L. Guo, P.C. Liao and C.C. Lee. 2006a. Interactive
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Chen, H.L., H.J. Su, Y.L. Guo, P.C. Liao, C.F. Hung and C.C. Lee. 2006b.
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Cheng, S.B., S. Kuchiiwa, I. Nagatomo, Y. Akasaki, M. Uchida, M. Tominaga, W.
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Choi, S.S., M.A. Miller and P.A. Harper. 2006. In utero exposure to
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Collins, J.J., R.A. Budinsky, C.J. Burns, L.L. Lamparski, M.L. Carson, G.D. Martin and
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Davies, R., B. Clothier, S.W. Robinson, R.E. Edwards, P. Greaves, J. Luo, T.W. Gant,
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Dragan, Y.P. and D. Schrenk. 2000. Animal studies addressing the carcinogenicity of
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