Status of Conditional Registrations under FIFRA sec. 3(c)(7)(C) from 2000 through 2017 (July 2018) ------- New Active Ingredient Registration Status 2000-2017 Ammonium Carbamate Division AD 2/24/2014 49496201 Satisfied Date Data 1. Green Algae Toxicity Study 11/24/2014 10/24/2014 Chem Satisfied Bethoxazin AD 6/6/2006 1. Fish Acute Toxicity Test, Freshwater and Marine 9/30/2006 46939003 Cancelled 9/20/2006 Cancelled July 2011 Chem Cancelled 2. Daphnid Chronic Toxicity Test 9/30/2006 46969001 Cancelled 9/20/2006 3. 90-Day Inhalation Toxicity 4/30/2007 Waiver requested Cancelled N/A Boric Acid AD 9/27/2007 1. Seedlinq Emerqence, Tier II 6/1/2008 47675201 Satisfied 2/13/2009 Chem Satisfied 2. Veqetative Viqor, Tier II 6/1/2008 47675201 Satisfied 2/13/2009 3. Duckweed Study 6/1/2008 47675202 Satisfied 2/13/2009 4. Alqal Toxicity, Tiers I and II 6/1/2008 47675203 Satisfied 2/13/2009 5. Fish Acute Toxicity Test, Freshwater and Marine 9/28/2008 47425202 Satisfied 5/15/2008 6. Mysid Acute Toxicity Test 9/28/2008 47425204 Satisfied 5/15/2008 7. Acute Embryo laivae 9/28/2008 47425201 Satisfied 5/15/2008 8. Green Alqae Study 6/1/2008 47425203 Satisfied 5/15/2008 9. Whole Sediment Freshwater 9/28/2008 Waiver requested Waived N/A 10. Whole Sediment Marine 9/28/2008 Waiver requested Waived N/A 11. Leachinq Study 11/28/2008 Waiver requested Waived N/A Cetyl pyridinium chloride AD 3/5/2009 1. Ready Biodeqradability 3/6/2010 49233702 Satisfied 9/26/2013 Chem Satisfied 2. Sediment and Soil Adsorption/Desorption Isotherm 3/6/2010 48012103 Satisfied 3/5/2010 3. Activated Sludqe Sorption Isotherm 3/6/2010 49233701 Satisfied 9/26/2013 4. Aerobic Deqradation 3/6/2010 48012105 Satisfied 3/5/2010 5. Alqal Toxicity, Tiers I and II 3/6/2010 48012106 Satisfied 3/5/2010 6. Activated Sludqe Sorption Isotherm 3/6/2010 48012107 Satisfied 3/5/2010 7. Bacterial Reverse Mutation Test 3/6/2010 48012108 Satisfied 3/5/2010 Copper Carbonate, basic (Polymeric Betaine) AD 10/31/2006 1. Mouse Carcinoqenicity Study 10/31/2009 47667001 Satisfied 2/9/2009 Chem Satisfied 2. Skin Sensitization 10/31/2007 Waiver requested Waived N/A 3. Hydrolysis 4/31/2007 47348101 Satisfied 2/15/2008 4. Aerobic Soil Metabolism 10/31/2007 47757601 Satisfied 5/22/2009 5. Avian Acute Oral 10/31/2007 46768502 Satisfied 2/24/2006 6. Fish Acute Toxicity Test, Freshwater and Marine 10/31/2007 Waiver requested Waived N/A 7. Aquatic Invetebrate Acute Toxicity, Test, Freshwater Daphnids 10/31/2007 Waiver requested Waived N/A 8. Other (fixation) 4/31/2007 47484102, 47484101, 47497001 Satisfied 7/22/2008 8/5/2208 DDAC AD 5/14/2003 1. 21/28-Day Dermal Toxicity 5/14/2004 47045101 Satisfied 2/1/2007 Chem Satisfied 2. Surface residue wipe study 5/14/2004 46764002 Satisfied 2/21/2006 3. Fish Early-Life Staqe Toxicity Test 5/14/2004 46914401 Satisfied 8/18/2006 4. Fish BCF 5/14/2004 45834101 Satisfied 1/9/2003 5. Whole Sediment Acute Toxicity Invertebrates, Freshwater 5/14/2004 45821701 Satisfied 12/20/2002 6. Whole Sediment Acute Toxicity Invertebrates, Marine 5/14/2004 45821702 Satisfied 12/20/2002 7. Honey bee toxicity study 5/14/2004 Waiver requested Waived N/A 8. Seedlinq Emerqence, Tier II 5/14/2004 46375401 Satisfied 10/1/2004 9. Veqetative Viqor, Tier II 5/14/2004 46414501 Satisfied 12/1/2004 10. Aquatic Plant Toxicity Test using Lemna spp. Tiers I and II 5/14/2004 46295804 Satisfied 6/16/2004 11. Anaerobic Aquatic Metabolism 5/14/2004 46124303 Satisfied 11/18/2003 12. Alqal Toxicity, Tiers I and II 5/14/2004 46295801 Satisfied 6/16/2004 13. Environmental monitorinq study 5/14/2004 46934201 Satisfied 9/14/2006 Fenpropimorph AD 9/27/2007 1. Seedling Emergence using rice (Oryza sativa), TEP 6/1/2008 47675201 Satisfied 2/13/2009 Chem Satisfied 2. Tier II Vegative Vigor using rice (Oryza sativa) TEO 6/1/2008 47675201 Satisfied 2/13/2009 3. Lemna qibba (duckweed) usinq TEP 6/1/2008 47675202 Satisfied 2/13/2009 4. Algal toxicity studies using TEP Anabaena flos- aquae (blue-green cyanobacteria) Noavicula pelliculosa (freshwater diatom) Skeletonema cosatum (marine diatom) 6/1/2008 47675203, 47675204 Satisfied 2/13/2009 5. Acute estuarine/marine fish 9/28/2008 47425202 Satisfied 5/15/2008 6. Acute Mysid shrimp 9/28/2008 47425204 Satisfied 5/15/2008 7. Acute embryo laivae usinq E. oyster 9/28/2008 47425201 Satisfied 5/15/2008 8. Selenastrum capricornutum (green algae) usinq TEP 6/1/2008 47425203 Satisfied 5/15/2008 7/31/2018 1 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemic.il Division 47425201 Satisfied Date Data 9. Whole sediment acute freshwater invertabrates usinq fenpropimorphic acid 9/28/2008 5/15/2008 10. Whole sediment acute marine invertabrates usinq fenpropimorphic acid 9/28/2008 47425201 Satisfied 5/15/2008 11. Leachability of Wood Preservatives 11/28/2008 Waiver requested Waived N/A Glycolic Acid AD 71654-1 1. Registered conditionally but no data required No Data Required N/A N/A N/A No Data Required Listeria specific bacteriophage AD 6/18/2008 1. Additional efficacy data (Monitoring Plan) Not specified 47242001 Satisfied 9/28/2007 Chem Satisfied Lonzabec AD 5/20/2006 1. Storaqe Stability /Corrosion Characteristics 12/1/2006 46309707, 46309706 Satisfied 7/8/2004 Chem Satisfied 2. Analytical Method 12/1/2006 46309707 Satisfied 7/8/2004 Potassium Hypochlorite AD 63838-10 1. Registered conditionally but no data required No Data Required N/A N/A N/A No Data Required Silver chloride AD 3/28/2006 1. Enforcement Analytical Method 6/28/2006 46914401 Satisfied 8/18/2006 Chem Satisfied Tolylfluanid AD 12/30/2007 1. Monitoring Study 3/1/2008 48071901 Study not acceptable but requirement later waived 4/22/2010 Voluntary cancellation (03/17/2015) Chem Cancelled Trimethoxysilyl quat AD 11/22/2006 1. Developmental Toxicity Study (to remove production cap of 10,000lbs) 1/31/2008 47449001 Satisfied 6/17/2008 Chem Satisfied 2. Enforcement Analytical Method 6/21/2007 47148601 Satisfied 6/7/2007 Aspergillus flavus AF36 BPPD 6/24/2003 1. Efficacy (Texas) 6/24/2006 46859502 Satisfied 6/15/2006 Chem Satisfied 2. 5-batch analysis 6/24/2006 46859501 Satisfied 6/14/2006 Aspergillus flavus NRRL 21882 BPPD 5/28/2004 1. Analysis and certified limits 11/28/2006 47008702 47189202 47349302 47364501 Satisfied 12/18/2006 7/26/2007 2/19/2008 3/6/2008 Chemn Satisfied 2. Product identity and composition 11/28/2006 47008702 47364501 Satisfied 12/18/2006 3/6/2008 3. Storaqe stability 11/28/2006 47364501 47349302 Satisfied 2/19/2008 4. Efficacy Not specified 47008701 47189201 47299401 Satisfied 12/18/2006 7/26/2007 12/6/2007 Bacillus subtilis QST713 BPPD 6/20/2000 1. Manufacturing process (upgrade submitted study; includes 5-batch analyses and quality control to limit microbial impurities) 6/20/2001 45206101 Satisfied 9/11/2000 Chem Satisfied 2. Freshwater fish toxicity/pathoqenicity 6/20/2001 45455202 Satisfied 7/17/2001 3. Freshwater aquatic invertebrate toxicity/pathoqenicity 6/20/2001 45455203 Satisfied 7/17/2001 4. 30-day toxicity/pathoqenicity in qrass shrimp 6/20/2001 45455204 Satisfied 7/17/2001 5. Non-tarqet insect - parasitic Hymenoptera 6/20/2001 45455205 Satisfied 7/17/2001 6. Honeybee study 6/20/2001 46172901 46172902 Satisfied 1/14/2004 7. Storaqe stability 6/20/2002 45188101 Satisfied 9/11/2000 Beauveria bassiana strain 447 BPPD 9/27/2002 5-batch analysis 6/30/2004 46480601 Satisfied 8/29/2005 Chem Satisfied Beauveria bassiana strain HF23 BPPD 12/27/06 1. 5-batch analysis 6/27/2008 47345701 Satisfied 2/14/2008 Chem Satisfied 2. Certification of limits 6/27/2008 47345701 Satisfied 2/14/2008 3. Unintentional inqredients 6/27/2008 47345701 Satisfied 2/14/2008 4. Human pathoqens 6/27/2008 47345701 Satisfied 2/14/2008 5. Storaqe stability 6/27/2008 47779201 Satisfied 6/16/2009 6. Viability data 6/27/2008 47345701 Satisfied 2/14/2008 Calcium lactate BPPD 2/15/2008 1. Efficacy 2/15/2009 N/A Cancelled N/A Registration of product with this active ingredient was cancelled on 9/3/2010. Chem Cancelled Chondrostereum purpureum BPPD 9/23/2004 5-batch analysis Not specified 46702401 Satisfied 12/5/2005 Chem Satisfied Coat Protein Gene of Plum Pox Virus BPPD 5/7/2010 1. Independent laboratory validation of analytical method 5/7/2011 4828401 Satisfied 11/3/2010 Chem Satisfied Coddling moth virus BPPD 6/20/2001 1. Cell culture study 6/30/2003 45650901 Satisfied 4/11/2002 Chem Satisfied Corn qluten meal BPPD 9/4/2002 1. Storaqe stability 3/4/2003 45870101 Satisfied 3/4/2003 Chem Satisfied COT102 x COT67B (Vip3Aa19 x FLCrylAb) BPPD 6/26/2008 1. Independent laboratory validation of analytical method 5/1/2009 47743201 Satisfied 5/1/2009 Chem Satisfied 2. 7-14 day Daphnia or aquatic invertebrate dietary study 5/1/2009 47779101 47779102 Satisfied 6/16/2009 3. Baseline susceptibility and diagnostic concentration determinations for major cotton pests 1/31/2009 47662801 Satisfied 2/2/2009 1. Soil degradation study (field) Not specified 47120701 Satisfied 5/2/2007 Chem Satisfied 7/31/2018 2 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Re.: Notice Date Condition.il Data Reciuirementlsl 2. Confirmatory Monarch butterfly data Not specified MRID tor Studv Submitted 45759701 Review Status Satisfied Date Data 9/18/2002 Comments CrylF (Event 281) and CrylAc (Event 3006) Bt in cotton1 BPPD 9/30/2004 1. Data supporting natural refuge as alternate host to Cotton Bollworm (CBW) 7/31/2005 46610301 46909901 47019301 Satisfied 8/1/2005 8/10/2006 12/29/2006 Chem Satisfied 2. Baseline susceptibility data and discriminating dose of toxins for Tobacco Budworm (TBW) and CBW 9/1/2005 46938701 47223501 Satisfied 1/31/2005 9/21/2006 9/5/2007 3. Avian chronic exposure study 9/30/2008 Waiver requested Waived 4/7/2006 4. Non-tarqet insect study (minute pirate buq) 9/30/2008 47462301 Satis ified 7/1/2008 5. Soil fate/terrestrial expression studies for long ranqe soil persistence Not specified 47214501 Satisfied 8/27/2007 Cry2Ab2 in cotton BPPD 6/14/2002 1. Heat stability study 6/30/2003 45086303 Satisfied 4/7/2000 Chem Satisfied 2. Confirmatory soil degradation study 6/30/2003 45806601 Satisfied 11/25/2002 3. Avian oral toxicity 6/30/2003 45086316 45086317 Satisfied 4/7/2000 4. Ladybeetle larval data 6/30/2003 45086311 Satisfied 4/7/2000 Cry3Bb1 (Event MON 863) BPPD 2/24/2003 1. Insect resistance management/pest biology research data 2/13/2005 45943801 46186501 46262701 46725901 46949101 Satisfied 5/29/2003 2/4/2004 5/4/2004 12/12/2005 10/4/2006 Chem Satisfied 2. Expression data 2/24/2005 46479902 Satisfied 2/25/2005 3. Field deqradataion studies 2/24/2005 46510301 Satisfied 3/31/2005 4. Laboratory toxicity data for 2 species of non- tarqet beetles 2/24/2005 46479904 46479905 Satisfied 2/25/2005 5. 3-year full-scale or semi-field studies - non- tarqet invertebrates Not specified 46262702 46262703 46394202 Satisfied 5/4/2004 11/1/2004 6. 6-week broiler dietary study Not specified 45941501 Satisfied 5/23/2003 Cry3Bb1 (Event MON 88017) BPPD 12/13/2005 1. Insect resistance management/pest biology research data Not specified 45943801 46186501 46262701 46725901 46949101 Satisfied 5/29/2003 2/4/2004 5/4/2004 12/12/2005 10/4/2006 The registration of this active ingredient required that the conditional data requirements for Cry3Bb1 (Event MON 863) must be satisfied. Chem Satisfied 2. Expression data Not specified 46479902 Satisfied 2/25/2005 3. Field deqradataion studies Not specified 46510301 Satisfied 3/31/2005 4. Laboratory toxicity data for 2 species of non- tarqet beetles Not specified 46479904 46479905 Satisfied 2/25/2005 5. 3-year full-scale or semi-field studies - non- tarqet invertebrates Not specified 46262702 46262703 Satisfied 5/4/2004 6. 6-week broiler dietary study Not specified 45941501 Satisfied 5/23/2003 Cry34Ab1 and Cry35Ab1 (Cry34/35Ab1) BPPD 8/31/2005 1. Laboratory toxicity data for 2 species of non- tarqet beetles 8/31/2007 46714101 47436701 Satisfied 12/20/2005 6/3/2008 This registration expired 9/30/2015. Chem Satisfied 2. 3-year full-scale field or semi-field studies - non tarqet invertebrates 9/30/2009 47870301 Satisfied 9/28/2009 3. 3-year field degradation study 1/31/2010 47959501 Satisfied 1/21/2010 Cydia pomonella Granulosis Virus BPPD 7/17/2000 1. Manufacturing process 7/17/2002 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/14/2010. Chem Cancelled 2. Analysis of Samples 7/17/2002 N/A Cancelled N/A 3. Product identity 7/17/2002 N/A Cancelled N/A 4. Certification of limits 7/17/2002 N/A Cancelled N/A 5. Acute Intraperitoneal toxicity/pathogenicity study 7/17/2002 N/A Cancelled N/A German Cockroach Pheromone BPPD 9/23/2004 1. 5-batch analysis 8/1/2005 46469401 46539801 Satisfied 2/14/2005 5/4/2005 Chem Satisfied Harpin proteins BPPD 4/19/2000 1. Freshwater invertebrate pathogenicity 4/19/2001 45380401 Satisfied 4/17/2001 Chem Satisfied 2. 5-batch analysis for suivival of Harpin- producing E. coli in end-prodct and quatitation of human pathoqens 4/19/2001 45380402 Satisfied 4/17/2001 3. Sample media without antibiotics to detect bacterial contamination 4/19/2001 45380402 Satisfied 4/17/2001 4. PCR-based amplification to detect/estimate residual plasmid in end-product 4/19/2001 45380403 Satisfied 4/17/2001 Metarhizium anisopliae F52 BPPD 6/6/2003 1. Manufacturinq process - upqrade 1/30/2011 48058801 Satisfied 4/12/2010 Chem Satisfied 2. Formation of unintentional ingredients - upqrade 1/30/2011 47880601 48177001 Satisfied 10/9/2009 8/6/2010 3. Freshwater Fish Testing - repeat 1/30/2011 Waiver requested Waived 12/9/2004 1/14/2008 7/31/2018 3 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Re.: Notice Date Condition.il Data Reciuirementlsl 4. Product identity - upgrade 1/30/2011 MRID tor Studv Submitted 47123901 Review Status Satisfied Date Data 5/4/2007 Comments MIR162 (Vip3Aa20) BPPD 11/26/2008 1. Analytical method validation 11/1/2009 N/A Satisfied 6/15/2009 Chem Satisfied 2. 7-14 day Daphnia study or aquatic invertebrate dietary study 11/1/2009 47779102 Satisfied 5/1/2009 MOCrylF (Event DAS-06275-8) BPPD 5/27/2005 1. I ndependent laboratory validation of analytical method Not specified 46656101 Satisfied 10/3/2005 Registration of products containing this active ingredient expired 9/30/2015. Chem Satisfied 2. Confirm moCrylF protein levels in soil under range of conditions typical for Bt corn cultivation. 3/15/2008 47120702 Satisfied 5/7/2007 3. Confirmatory non-tarqet insect field data 3/15/2008 46784601 Satisfied 3/15/2006 MON 89034 (Cry1A.105 and Cry2Ab2) BPPD 6/10/2008 1. 7-14 day daphnia study or aquatic invertebrate dietary study 4/1/2009 47838801 Satisfied 8/27/2009 Chem Satisfied 2. Info on cross-resistance of Cry1 A. 105, CrylF and CrylAc for target pests, and impact on the durability of MON 89034 4/1/2009 47838801 Satisfied 8/27/2009 3. Sweet Corn: baseline susceptibility studies of major pests 4/1/2009 47791201 47791202 47791203 Satisfied 7/14/2008 6/30/2009 6/30/2009 4. Sweet corn: baseline Fall Army Worm susceptibility studies to the 2 proteins 4/1/2009 48588801 48588802 48588803 Satisfied 8/30/2011 U 5. Analytical method validation, including reaqents/methodoloqy 4/1/2010 47731601 Satisfied 4/22/2009 Muscador albus BPPD 9/22/2005 1. 5-batch analysis Not specified 47526001 Cancelled 9/2/2008 Registrations of products with this active ingredient were cancelled on 10/4/2010. Chem Cancelled 2. Storaqe stability 9/1/2008 47526002 Cancelled 9/2/2008 3. Acute inhalation toxicity 1/31/2007 47043801 Cancelled 1/31/2007 Nuclear Polyhedrosis Virus of Anagrapha falcifera BPPD 8/92002 1. Analysis of samples 1/8/2003 46228201 Satisfied 3/22/2004 Chem Satisfied Oil of Black Pepper and Piperine BPPD 3/18/2004 1. Storage stability 12/1/2005 46717901 Satisfied 12/27/2005 Chem Satisfied Paecilomyces lilacinus strain 251 BPPD 3/30/2005 1. Acute intraperitoneal toxicity pathogenicity study 9/30/2006 46950401 47197501 Satisfied 8/6/2007 Chem Satisfied Pseudomonas chloroaphis strain 63-28 BPPD 9/28/2001 1. Data demonstrating production of siderophores 6/28/2004 46615902 46766902 Cancelled 8/4/2005 2/23/2006 This registration containing this active ingredient was cancelled on 7/22/2013. Chem Cancelled 2. Growth and suivival of microbe at 10-25°C 6/28/2004 46615901 46615901 Cancelled 8/4/2005 2/23/2006 Pseudozyma flocculosa strain PF-A22 BPPD 9/20/2002 1. Confirmatory pulmonary toxicity/pathogenicity study 10/3/2003 7/1/2005 4/1/2006 9/20/2006 6/1/2007 10/31/2007 10/31/2008 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/15/2011. Chem Cancelled 2. Storage stability 10/3/2003 7/1/2005 4/1/2006 9/20/2006 6/1/2007 10/31/2007 10/31/2008 N/A Cancelled N/A 3. Certificates of Analysis Not specified N/A Cancelled N/A Trypsin modulating oostatic factor (TMOF) BPPD 5/24/2004 1. Storage Stability 5/24/2006 N/A Cancelled N/A Registrations of products with this active ingredient were cancelled on 7/21/2005. Chem Cancelled Xanthomonas campestris pv vesicatoria and Pseuodomonas syringae pv tomato (2 active inqredients) BPPD 12/9/2005 1. PCR-based screen maintain/report QA/QC 6/9/2006 46887301 Satisfied 6/12/2006 Registrationsof products with this active ingredients requires ongoing QA/QC data to be submitted to EPA whenever requested. All other conditions of registration are satisfied. Chem Satisfied Quillaja saponaria extract BPPD 7/14/2007 1. Product performance (efficacy) 7/15/2010 47645201 to 47645212 48151401 to 48151413 Satisfied 1/15/2009 7/15/2012 Chem Satisfied Trichoderma harzianum strain BPPD 5/25/2000 1. Efficacy of PCR-RAPD protocol for strain identity 8/25/2000 N/A Cancelled Not submitted Registrations of products with this active Chem Cancelled 2. 5-batch analysis 5/25/2001 N/A Cancelled Not submitted 3. Freshwater invertebrate study verification Not specified 44890101 Cancelled 8/23/2000 7/31/2018 4 of 18 ------- New Active Ingredient Registration Status 2000-2017 4. Plant-pathogenicity 5. Non-target insect (Ladybird beetle) 6. Upgrade honeybee study Not specified Not specified 5/25/2001 Datp Data Not submitted Not submitted (Z,E)-9, 12 Tetradecadien-1-yl acetate 1. Storage stability The conditions of registration are satisfied. Z,Z-3, 13- Octadecadien-1 -ol 1. Storage stability 10/20/2007 2/28/2014 2. Corrosion characteristics 10/20/2007 2/28/2014 New registration notice mailed to registrant 9/25/2014 Chem Satisfied 1.Freshwater invertebrate (Daphnia) study Acequinocyl 2. Acute sediment toxicity test for freshwater invertebrates for the major metabolite, deacetylated acequinocyl; pending results on freshwater invertebrates, the test for sediment dwelling estaurine/marine invertebrates may be required. If required, it is to be submitted within 1 year of the date of the Agency's notification to company 3. Acute toxicity study for the deacetylated acequinocyl using fish (rainbow trout; or bluegill sunfish) 4. Acute toxicity study for the deacetylated acequinocyl using an aquatic invertebrate using daphnids or mysids as the test species Storage stability and corrosion characteristics Chem Satisfied Acetaminophen 1. Conditionally registered but no data requirements No Data Required 1. Storage Stability Data for Rotational Crops 2. Radio validation data for IM-2_1 amide in ruminant muscle Waiver requested Acetamiprid 3. Avian Reproduction 4. Acute Aquatic Invertebrate 46369201 46555601 45932501 45916201 49034202 Freshwater Fish Early Life-Stage Toxicity of Foliar Residue to the Honey Bee 45932505 45932504 Tier II Phytotoxicity, Vegetative Vigor - Lettuce 46229602 46229601 Chem Satisfied Waiver requested on 12/17/02. Data indicate that residues of IM-2-1 amide in ruminant muscle can be estimated by applying a 10-fold factor to residues of IM- 2-1 in muscle. Submission of these data would result in the use of empirical data in risk assessments and removal of the 10- fold factor used to estimate residues of IM- 2-1. 5/14/2003; 1/09/2013 Decision made that no further data are required. Alpha-Chlorhydrin Registered conditionally but no data required No Data Required 1. Storage stability data for the benzene-labeled rate rice metabolism study 2. Poultry feeding study 48060601 requested Bispyribac- Sodium 3. 28-day inhalation 48578001 requested 4. In vitro mammalian cell gene mutation assay 46076601 5. Residue data generated for the vegetative vigor of terrestrial plants Waiver requested 6. Residue data generated for the seedling emergence of terrestrial plants Waiver requested 7. Toxicity study to green algae 46076602 Chem Satisfied Waiver; DP 377208; acceptable Waiver; DP 394228; waived Waiver; DP 287947; acceptable Waiver; DP 287947; acceptable 1. Ruminant feeding study 2. Repeat of the 21-day chronic toxicity test with freshwater invertebrates 3. Repeat of the acute toxicity study on plants with a plant species that can provide a better representation of the toxicity of parent butafenacil to vascular plants 4. Chronic toxicity test with an estuarine/marine invertebrate species. All products cancelled on 7/16/07 Chem Cancelled All products cancelled on 7/16/07 All products cancelled on 7/16/07 All products cancelled on 7/16/07 7/31/2018 5 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Date Data 5. Repeat of the tier II seedling emergence 123- 1(a) 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 6. Repeat of the veqetative viqor 123-1(b) 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 7. Acute fish study with parent butafenacil in the presence of natural sunlight or an equivalent source 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 8. Frozen storaqe stability data 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 9. Ruminant validation method 9/29/2006 N/A Cancelled N/A All products cancelled on 7/16/07 1. Acute neurotoxicity study in rats 6/1/2003 46012992, 46012947 Satisfied 6/3/2003 Chem Satisfied 2. Subchronic neurotoxicity study in rats 6/1/2003 46012921, 46012946 Satisfied 6/3/2003 3. Developmental neurotoxicity study in rats 6/1/2003 46012925 Satisfied 6/3/2003 4. In vitro cytoqenetic assay 6/1/2003 46012919 Satisfied 6/3/2003 5. Nature of the residue in plants 6/1/2003 46012908, 46012909 Satisfied 6/3/2003 6. Residue analytical methods 6/1/2003 46012912, 46012914 Satisfied 6/3/2003 7. Storaqe stability data 6/1/2003 46012916, 46012917 Satisfied 6/3/2003 Clodinafop- propargyl 8. Maqnitude of the residue in plants 6/1/2003 46012918 Satisfied 6/3/2003 RD 6/6/2000 9. Hydrolysis 6/1/2003 46012926 Satisfied 6/3/2003 10. Photolysis in water 6/1/2003 46012927, 46012928 Satisfied 6/3/2003 11. Anaerobic soil metabolism on deqradate 6/1/2003 Not submitted Waived 6/3/2003 Requirement withdrawn 12. Adsorption/desorption 6/1/2003 46012934, 46012935, 46012936, 46012937 Satisfied 6/3/2003 13. Field dissipation 6/1/2003 46012939 Satisfied 6/3/2003 14. Aerobic soil metabolism 6/1/2003 46012930, 46012931 Satisfied 6/3/2003 15. Avian reproduction 6/1/2003 46012945 Satisfied 6/3/2003 16. Seedlinq emerqence/veqetative viqor 6/1/2003 46012902, 46012901 Satisfied 6/3/2003 1. Developmental immunotoxicity study 5/30/2006 46536502, 46536501 Satisfied 4/29/2005, 4/292008 Chem Satisfied 2. Additional analysis of test materials used in mutaqenicity studies 5/30/2006 46339001, 46339002, 46339003, 46339004 Satis ified 8/10/2004 Clothianidin RD 5/30/2003 3. Rotational crop residue field trials with mature soybeans 5/30/2006 46826901 Satisfied 5/15/2006 4. Aerobic aquatic metabolism 5/30/2006 46826903 Satisfied 5/15/2006 5. Seed leachinq study 5/30/2006 46826904 Satisfied 5/15/2006 6. Whole sediment acute toxicity to freshwater invertebrates 5/30/2006 46826902 Satisfied 5/15/2006 7. Field test for pollinators 5/30/2006 46907801, 46907802 Satisfied 8/9/2006 1. 28-day inhalation toxicity study 6/1/2006 46471101 Satisfied 2/15/2005 Chem Satisfied Cyhalofop-butyl RD 5/23/2002 2. Carcinogenicity study in rats 6/1/2006 46471101, 46471102, 46471103 Satisfied 2/15/2005 3. Carcinogenicity study in mice 6/1/2006 46471101, 46471102, 46471103 Satisfied 2/15/2005 Difenacoum RD 9/28/2007 1. Reqistered conditionally but no data required No data req. N/A N/A N/A Chem Satisfied 1. Stability to metals and metal ions No date specified 46403801 Satisfied 11/12/2004 Chem Satisfied 2. Confirm sample extraction and analysis dates for MRID 45639822. 12/17/2004 No MRID assigned Satisfied 2/3/2005 Information submitted in conjunction with a new use application. 120 Day plant back interbal retained. 3. Confirmatory dermal absorption study in the rat 9/17/2005 47013401 Satisfied 12/22/2006 4. Developmental neurotoxicity study in the rat 9/17/2006 47677502, 48291601 Satisfied 2/17/2009 5. Developmental immunotoxicity study in the rat with comparative measures between pups and the parents. 9/17/2006 47677501 Satisfied 2/17/2009 6. Photodegradation in soil 9/17/2005 45640109 Satisfied 8/24/2010 Referred to study received 3/19/2002. Satisfied Dinotefuran RD 9/17/2004 7. New aerobic soil metabolism or upgrade 2nd study (MRID 45640112) by addressing the characterization of the major degradates at various samplinq internals. 9/17/2005 46711201, 46711202 Satisfied 12/16/2005 8. Anaerobic Aquatic/soil metabolism study needs to be upgraded if direct application to water is proposed. Not specified 48680002 Satisfied 12/6/2011 Submitted with rice application. Satisfied 9. Aerobic aquatic metabolism study needed for any future aquatic uses. Not specified 48680002 Satisfied 12/6/2011 Submitted with rice application. Satisfied 10. Repeated fish early life stage toxicity test 9/17/2005 45639719 Satisfied 8/24/2010 Referred to study received 3/19/2002. Satisfied. 11. Avian acute oral test using bobwhite quail or mallard duck 9/17/2005 47353601 Satisfied 2/25/2008 Satisfied 7/31/2018 6 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Re,; Notice Date MRID tor Study Submitted Date Data Comments 12. Aquatic invertebrate life cycle test is needed for any future aquatic uses. Not specified 45639718 Satisfied 8/24/2010 Referred to study received 3/19/2002. Satisfied. Eco2Fume RD 12/20/1999 Conditionally registered under 3(c )(7)(c ) but no data requirements No data required N/A N/A N/A No Data Required 1. Product chem. Data partially satisfied and needed: product identity and discussion of ingredients, beginning materials and manufacturing process, formation of impurities, prelim analysis, analytical methods to verify cert limits, and stability. NOT satisfied: oxidizing or reducing action, explodability, storage stability, corrosion characteristics. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 Chem Cancelled 2. Hydrolysis study needs the % of phenyl-ring transformation products that are present after 30 days 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 3. Photodegradation in water: electronic absorption spectra of ethametsulfuron methyl at ph5 and 9. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 Ethametsulfuron Methyl RD 4/23/2001 4. Aerobic soil metabolism: triazine radiolabeled study to address comments in study review. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 5. Terrestrial field dissipation study: Analytical method for identifying and quantifying residues of "cold" ethametsulfuron methyl must be evaluated 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 6. Freshwater fish full life-cycle 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 7. Tier II seed qermination/seed emerqence 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 8. Tier II veqetative viqor 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 9. Tier II Lemma gibba, Skeletonma costatum, blue qreen alqae 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 10. Batch equilibrium adsorption/desorption study were conducted with acidic soils taken from eastern states. At least 2 alkaline soils should be included. Soil TLC studies only provide ancillary data. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 11. Additional information required for acute inhalation and dermal sensitization studies. Refer to review. 4/23/2005 N/A Cancelled N/A All products cancelled on 2/20/13 1. Acute and subchronic neurotoxicity 3/1/2003 45932301, 45925701 Satisfied 4/22/2003 Chem Satisfied 2. Development neurotoxicity 9/1/2003 46062301 Satisfied 8/28/2003 Etofenprox RD 9/14/2001 3. ResidentiaT'lndoor Surface Residue Dissipation Study following Total Release Product Use" 9/1/2003 46075002 Satisfied 9/3/2006 4. Residential "Indoor Air Concentration Measurements following Total Release Product Use" 9/1/2003 46075003 Satisfied 9/3/2006 5. Product Performance Data for cockroaches, fleas, ticks, and mosquitoes 9/1/2002 46066506 Satisfied 9/5/2003 Etoxazole RD 8/22/2002 1. Core freshwater fish acute toxicity studies Not specified 46059001, 46059002 Satisfied 8/25/2003 Chem Satisfied 2. 90-day subchronic inhalation study on rats Not specified 48134301 Waiver requested Waived 6/28/2010 1. Honey bee acute contact LD50 12/1/2003 45802901 Satisfied 11/19/2002 Chem Satisfied 2. Mallard duck reproduction 12/1/2004 46418601 Satisfied 12/6/2004 3. Freshwater fish early life-stage or fish full life cycle 12/1/2004 47332201 Waiver requested; 48389201 study Satisfied 12/6/2004; 2/16/2011 Waiver denied; study satisfied requirement. 4. Aerobic soil metabolism 12/1/2004 45385819 Satisfied 11/21/2002 5. Residue analytical methods-plants any modification or revisions recommended by the Aqency 6/1/2003 No modifications requested Satisfied 11/21/2002 Fenamidone RD 9/30/2002 6. Confined accumulation in rotational crops- fenamidone labeled in the N-phenyl ring (aniline and substituted aniline standards should be included) 12/1/2003 Waiver requested Waived 11/21/2002 7. Confined accumulation in rotational crop study 12/1/2003 46440805, 47514101, 47514102, 47514103 Satisfied 1/2/2005 8/12/2008 8/12/2008 8/12/2008 7/31/2018 7 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Re.: Notice Date Condition.il Data Reciuirement(s) MRID tor Studv Submitted Review Status Date Data Comments 8. Storage stability data for the confined accumulation in rotational crop study 12/1/2003 47817002 Satisfied 7/30/2009 9. Developmental neurotoxicity study 12/1/2003 46501102, 46590001 Satisfied 3/18/04, 7/12/05 10. 28-day inhalation toxicity study 12/1/2003 47465801 Waiver requested Waived 7/2/2008 11. Storaqe Stability 3/1/2004 47817002 Satisfied 7/30/2009 12. Corrosion Characteristics 3/1/2004 46152101 Satisfied 12/15/2003 Fenpyroximate RD 9/29/2000 1. Confirmatory data must be submitted for the existing rat developmental study including additional historical control data. 9/27/2003 45323301 Satisfied 2/6/2001 Chemical Satisfied 2. 28-day inhalation study 9/27/2003 45323302 Satisfied 2/6/2001 3. Aerobic soil metabolism and adsorption/desorption (batch equilibrium) study. 9/27/2003 45649708 Satisfied 4/1/2002 Flazasulfuron RD 5/14/2007 1. One-year storage stability and corrosion characteristics 11/14/2008 46220905 Satisfied 3/2/2004 Agency letter, dated 11/20/08, states that the study submitted with the application satisfies the requirement. Chem Satisfied 2. Acute neurotoxicity study including historical positive control data, analytical data verifying homogeneity, and stability of formulated test materials for this study. 6/30/2009 47785301 Satisfied 6/23/2009 DP366699 acceptable, DP404895 acceptable, DP408778 acceptable 3. Aerobic aquatic metabolism 6/30/2009 47785302 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement 4. Aerobic soil metabolism 6/30/2009 47785303 Satisfied 6/23/2009 DP366710, acceptable 5. Anaerobic aquatic metabolism 6/30/2009 47785304 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement 6. Soil Mobility: Adsorption/desorption (parent) 6/30/2009 47030002 Satisfied 1/2/2013 7. Freshwater fish early life-staqe 6/30/2009 47785305 Satisfied 6/23/2009 DP366710, acceptable 8. Aquatic invertebrate life-cycle (freshwater) 6/30/2009 47785306 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement 9. Aquatic vascular plant (duckweed) study 6/30/2009 47785307 Satisfied 6/23/2009 DP366710; supplemental, satisfies requirement 10. Seedlinq emerqence (Tier II) 6/30/2009 47785308 Satisfied 6/23/2009 DP366710, DP372895 acceptable 11. Studies need to be conducted on the hydrolysis degradates DTPU and DTPP at the pH(s) at which they are most stable to hydrolysis No date specified 47785309 Satisfied 6/23/2009 DP366710, acceptable Fluazinam RD 3/5/2003 1. 28-day inhalation toxicity study in rats 12/1/2003 48571410 Satisfied 9/8/2011 Waiver request submitted in 2002 was deemed acceptable due to label mitigation (inclusion of respirator). Full study was submitted in 2011 as part of registration review Chem Satisfied 2. Developmental neurotoxicity study in rats (Submit protocol for Agency approval and submit the study 2 years after approval 3/13/2003 (protocol due) 4654401, 47018301, 47037001 Satisfied 4/28/2005 3. Subchronic neurotoxicity screening battery in rats, required based on results of the developmental neurotoxicity study (must by submitted 2 years after notification by the Agency N/A N/A Waived N/A Data not requested based on results of developmental neurotoxicity studies. 4. Processed commodity study on potatoes at a hiqher treatment level, 5x 12/3/2003 Waiver requested and granted Satisfied 1/17/2002 5. Photodeqration in soil 12/1/2003 45584205 Waiver requested Waived 10/28/2008 6. Terrestrial Field Dissipation and concurrent storaqe stability study 12/1/2004 48631521, 48631522, 48631523 Satisfied 10/28/2008 7. Tier I or Tier II Terrestrial Plant Growth, seedling emergence and vegetative vigor by 12/2003 12/1/2003 46172801, 46172802 Satis ified 1/15/2004 Flubendiamide RD 8/1/2008 1. Vegetative Filter Strip Study 7/31/2010 48175602, 48175604, 48175606 Satisfied 11/8/2010 Chem Satisfied 2. Protocol for Farm Pond Watering Program Study 8/3/2010 48535201 48535201 (approval of NC monitoring site) 48644901 (approval of GA monitorinq site Satisfied 11/8/2010 3. Farm Pond Water Monitoring Program Study 1/31/2012 49415301, 49415302, 49415303 Satisfied 2/20/2015 1. Additional storage stability data for the metabolite S-3153 acid-4-OH in field corn and stover 9/30/2004 46028601 Satisfied 7/10/2003 Chem Satisfied 7/31/2018 8 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Date Data Flufenpyr-ethyl RD 9/30/2003 2. Confirmatory method for residues of flufenpyr- ethyl in/or on corn, soybeans, sugarcane raw agricultural commoditities (RACs) by 9/30/2004. If the confirmatory method does not utilize a mass- selective detector (MSD), then an interference study will be required. 9/30/2004 46028602 Satisfied 7/10/2003 1. Confirmatory residue analytical method for plants 4/12/2003 45914603 Satisfied 4/22/2003 Chem Satisfied Flumioxazin RD 4/12/2001 2. Aqueous photolysis 4/12/2003 45914601 Satisfied 4/22/2003 3. Anaerobic soil/aqueous soil metabolism 4/12/2003 45914602 Satisfied 4/22/2003 4. Field dissipation 4/12/2003 46163701 Satisfied 4/22/2003 1. Additional storage stability data are needed for celery and spinach relfecting a storage interval of 38 months. One study should be conducted on any representative leafy vegetable. 1/31/2009 49054401, 49054402, 49054403, 49054404 Satisfied 2/6/2013 Chem Satisfied 2. Provide sample history of cow metabolism study (46708514). 1/31/2009 47689304 Satisfied 2/24/2009 Fluopicolide RD 1/28/2008 3. Provide storage stability, clarify identification of peaks, correct flowchart for fat, recalculate the radioactivity levels for the cow metabolism study (46708518). 1/31/2009 47689305 Satis ified 2/24/2009 4. Provide sample history of the hen metabolism study (46708515). 1/31/2009 47689303 Satisfied 2/24/2009 5. Provide stability data for the duration of the storage period for the hen metabolism study (46708519). 1/31/2009 47689306 Satisfied 2/24/2009 1. Fish early life staqe study 3/27/2004 46241301 Satisfied 4/5/2004 Chem Satisfied 2. Seed germination/seedling emergence study conducted usinq the end-use product 3/27/2004 45483801 Satisfied 8/24/2001 3. Vegetative vigar study conducted using the end-use product 3/27/2004 45483802 Satisfied 8/24/2001 Foramsulfuron RD 3/27/2002 4. Tier II aquatic plant growth study conducted usinq the end-use product 3/27/2004 45109911 Satisfied 4/3/2000 5. Submit an acceptable study to complete the data requirement as specified in the Confidential Attachment to the Registration Notice. 3/27/2004 45554701; 45562501;45562501; 45562502 Satisfied 4/8/2002 1. The final report of the 3 year storage stability data for tomato 12/30/2008 45866701 Satisfied 8/24/2009 Chem Satisfied 2. Tobacco storage stability study (data depicting frozen storage stability of foshiazate and ASC- 67131 in a representative foliage commodity 12/30/2008 45866701(tomato) and 45866705 (tobacco) Satisfied 2/27/2003 Registrant submitted the studies prior to registration in response to the Agency's residue chemistry review of 8/27/2002. 3. Analytical grade reference standards for the foshiazate metabolite ASC-67131 must be submitted to the EPA standards repository 12/30/2008 No MRID number. Satis ified N/A Sample shipped to EPA's standards repository on 12/6/2004 Fosthiazate RD 3/30/2004 4. Additional data to characterize insoluble residues in 30 days after treatment (DAT) rotated wheat commodities 12/30/2008 Waived 8/24/2010 Required only for a pending use that was not registered. 5. Storage stability data to support the additional analyses required on the 30-DAT wheat forage, straw, and qrain 12/30/2008 Waived 8/24/2010 Required only forpending use that was not registered. 6. 28-day inhalation study in rats with foshiazate 12/30/2008 46744901 Satisfied 1/30/2006 7. Developmental neurotoxicity (DNT) study in rats with comparative ChE measurements in adults and pups 12/30/2008 46784301 waiver requested and granted Waived 5/15/2006 8. A worker study for activities involving contact ith treated soil conducted concurrently with a soil residue dissipation study. 12/30/2008 47098901 waiver request Waived 4/2/2007 Agency did additional risk assessments and concluded MOEs are adequate. Requirement withdrawn. 1. 28-day dermal toxicity study no date specified 46917201 Satisfied 8/21/2006 Chem Satisfied Furfural RD 10/5/2006 2. Guideline 28- or 90-day inhalation study no date specified 46917202, 47419101, 46426505 Satisfied 8/21/2006, 5/19/2008 3. Field/greenhouse volatility study for each major application method no date specified 47253701 Satisfied 10/11/2007 4. Dislodqeable foliar residue study no date specified 47146202 Satisfied 6/19/2007 7/31/2018 9 of 18 ------- New Active Ingredient Registration Status 2000-2017 Division Re.: Notice Date Condition.il Data Reciuirementlsl MRID tor Studv Submitted Date Data 1. Product identity and composition 1/30/2002 45591501 Satisfied 1/30/2002 Chem Satisfied 2. Description of materials used to produce the product 1/30/2002 45591501 Satisfied 1/30/2002 3. Description of production process 1/30/2002 45591501 Satisfied 1/30/2002 4. Description of formulation process 1/30/2002 45591501 Satisfied 1/30/2002 5. Discussion of formation of impurities 1/30/2002 45591501 Satisfied 1/30/2002 5. Discussion of formation of impurities 10/30/2002 46749001, 46749002, 46749003 Satisfied 2/2/2006 7. 90-day inhalation toxicity study in the rat 10/30/2002 45354001 Satisfied 2/2/2006 8. Poultry feedinq study 10/30/2002 46114302 Satisfied 11/6/2003 9. Confirmatory method for plants 10/30/2002 45795818 Satisfied 11/4/2002 Indoxacarb RD 9/29/2000 10. Specificity testing for analytical methods for plants 10/30/2002 45795818 Satisfied 11/4/2002 11. Storage stabiliry data reflecting the maximum frozen storage internals of cotton processed samples 10/30/2002 45795819 Satisfied 11/4/2002 12. Photodeqradation in water 10/30/2002 45795802 Satisfied 11/4/2002 13. Hydrolysis 10/30/2002 45795801 Satisfied 11/4/2002 14. Aerobic soil metabolism 10/30/2002 45795803, 45906701 Satisfied 11/4/02, 4/11/03 15. Anaerobic aquatic metabolism 10/30/2002 45795804 Satisfied 11/4/2002 16. Aerobic aquatic metabolism 10/30/2002 45793301 Satisfied 10/31/2002 17. Leaching-adsorption/desorption 10/30/2002 45795805, 45795806, 45795807,45795808, 45906702 Satisfied 11/4/02, 4/11/03 18. Terrestrial field dissipation 10/30/2002 45795810, 45795811 Satisfied 11/4/2002 19. Accumulation in fish 10/30/2002 45805301 Satisfied 11/22/2002 lodomethane RD 10/5/2007 Agency does not request any additional conditional data in req. notice no additional data required N/A N/A N/A No Data Required 1. Avian reproduction studies 12/31/2004 46431803 Satisfied 12/27/2004 Chemical Satisfied 2. Freshwater fish early-life staqe studies 12/31/2004 46431804 Satisfied 12/27/2004 3. Estuarine invertebrate life-staqe studies 12/31/2004 48288301 Satisfied 11/5/2010 4. Carcinogenicity study in mice 12/31/2004 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) 5. Developmental toxicity study in rabbits 12/31/2004 Waiver Requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) lodosulfuron- methyl-sodium 6. 28-day inhalation study 12/31/2003 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) RD 10/26/2002 7. 21-day dermal study 12/31/2003 Waiver requested Waived 1/4/2008 Waivers found acceptable within HED risk assessment (D350046) 8. Analytical methods in plants, soil, and water. 12/31/2004 N/A N/A N/A For this requirement, the registrant understood in a meeting with the Agency on 4/9/2003 that the requirement was placed in reseive pending consultation with industry working groups on ways to address the requirement. This chemical is currently in registration review and this required is included in the DCI. 1. 28-day dermal toxicity study in rats 4/30/2006 47048916 Satisfied 5/15/2006 Chem Satisfied 2. 90-day inhalation toxicity study in rats 4/30/2006 47048915 Satisfied 4/19/2005 Ipconazole RD 9/10/2004 3. Additional soil adsorption/desorption study conducted in a low orqanic matter (OM) soil 4/30/2006 46827503 Satisfied 5/15/2006 4. In vivo cytoqenic assay 4/30/2006 46827502 Satisfied 5/15/2006 1. 90-day dermal study in the rabbit 3/31/2004 46273804 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived Chem Satisfied Macleaya Extract RD 9/19/2002 2. 90-day inhalation in rats 3/31/2004 46273806 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived 3. Developmental study in the rabbit 3/31/2004 46273807 Waived 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. HAZPOC waived 4. Mutagenicity battery (gene mutation in bacteria) and mammamalian cells, and an in vivo cytoqenetics assay 3/31/2004 46273814, 46273811, 46273812 Satisfied 5/18/2004 Study called in under Registration Review Data Call-In Notice issued 6/12/2012. Mammalian Gonadotropin RD 9/29/2009 1. Guideline 830.1700 Preliminary analysis and validation of the method of analysis of the formulation 9/29/2010 48623801 Satisfied 9/29/2011 Chem Satisfied 7/31/2018 10 of 18 ------- New Active Ingredient Registration Status 2000-2017 2. Guideline 830.1750 Certified Limits (basic and alternate CSFs) 1. Developmental neurotoxicity study in the mouse. 2. Adequate storage stability data in the plant and livestock metabolism studies 3. Revised interference study 45651816 4. 28-day Inhalation study 5. Phytotoxicity studies 46562908 Waiver requested 47093501 6. Improvement in the extraction method in the soil analytical method 7. A prospective groundwater monitoring study at a vulnerable site in the southern US. Chem Satisfied Metaflumizone 1. Storage and corrosion characteristics Chem Satisfied 1. Fish toxicity bluegill study 2. Honey bee acute contact 47046301, 47414001 2/2/2007, 4/30/2008 Chem Satisfied 1. Immunotoxicity study needed for future uses 2. Method validation data must be submitted for Method FAMS 105-01 reflecting fortifications at 4.5 ppm for grapes, and at both the LOQ (0.05 ppm) and 17 ppm for raisins. 48981303, 48981304 3. Radiovalidation for method FAMS 105-01 to demonstrate recovery of weathered residues of metrafenone from grapes. Cucumber data may be submitted in lieu of grapes if the data show adequate extractibility by 9:2 n-heptane/acetone. 48981305-48981308 4. Radiovalidation data are required to support the data collection method, BASF Method 535/0. Samples from the cucumber metabolism study currently in progress may also be used to generate these data. 48981305-48981308 5. Avian acute oral with passerine birds 6. Acute tox freshwater fish 7. Chronic freshwater fish early-life stage 8. Chronic aquatic freshwater invertebrate life- cycle 9. Acute marine/estuarine invertebrate 10. Aquatic vascular plant growth Tier II 11. Aquatic non-vascular Tier I 48981315-48981321 12. Chronic freshwater invertebrate whole sediment on TGAI for Chironomus dilutus 48981320-48981322 13. Storage stability and corrosion characteristics Chem Satisfied 1. Acute inhalation toxicity (technical)- rat (not upgradable-must be repeated) 2. 28-day dermal toxicity-rabbit (not upgradable- must be repeated) 3. Prenatal developmental toxicity-rabbit (possibly upgradable) 4. Prenatal development toxicity- rat (possibly upgradable) 5. Multigeneration reproductive toxicity-rat (possibly upgradable) 6. Estuarine fish early life-stage- sheepshead minnow 7. Estuarine invertebrate life-stage- mysid 8. Aquatic acute sediment toxicity testing 9. Anaerobic aquatic metabolism (possibly upgradable) 10. Bioconcentration in fish (possibly upgradable) Voluntarily cancelled. Chem Cancelled Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. Voluntarily cancelled. 1. Storage stability and corrosion characteristics studies 46416408 Chem Satisfied 1. 90-day inhalation toxicity study in rats Waiver requested Chem Satisfied 7/31/2018 11 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Jlyisi&n Uga jtfgtics ©site MRID tor Studv Submitted Review Status Date Data Comments Novaluron RD 9/25/2001 2. Two mutagenicity studies: In vitro mammalian cell gene mutation and in vivo cytogenetics assay 9/25/2003 45638321, 45638222 Satisfied 3/22/2002 1. Seed germination/seeding emergence studies, vegetative vigor studies, and an aquatic plant growth study using Duckweed with the degradates, BSA, 2-amino-TP, TPSA, BSTCA methyl, BSTCA, 2-amino-TCA, 5-OH- penoxsulam, SFA, sulfonamide, 5, 8-di-OH and 5- OH 2 amino TP No date specified 46758301, Exhibit A in 46758300 Satisfied 2/13/2006 Chem Satisfied Penoxsulam RD 9/27/2004 2. Test terrestrial plants using the liquid and end- use products of penoxsulam. No date specified 46930301, 46930302 Satisfied 2/13/2003 3. Enforcement method revised as recommended in the Analytical Chemistry laboratory memo dated 9/17/2004 No date specified 46389701 Satisfied 10/26/2004 4. One year storage stability and corrosion characteristics No date specified 46433901, 46433902, 46449901 Satisfied 12/28/2004, 12/28/2004, 1/24/2005 1. 5 week oral toxicity study in rats 4/15/2001 45387901 Satisfied 12/1/2002 Chem Satisfied 2. 14 week oral toxicity study in rats. 4/15/2001 45387902 Satisfied 12/1/2002 Picaridin RD 12/7/2000 3. Submit the protocol and locations for conduct of the 2001 market test for 2000 human subjects. 3/1/2001 Correspondence - no MRID assigned Satisfied 2/28/2001 4. Submit the results of the marketing test with up to 2000 subjects. 12/1/2001 Correspondence - no MRID assiqned Satisfied 9/27/2001 1. Additional validation data for pinoxaden and M2 residues in livestock commodities Not specified 47293207 Satisfied 11/30/2007 Chem Satisfied 2. Storage Stability Data for Rotational Crops in barley for 15 months and wheat for 6 months. Not specified 47293208 Satisfied 11/30/2007 3. Fish acute toxicity tests required for parent pinoxaden to replace supplemental studies Not specified 47293202 Satisfied 11/30/2007 4. Freshwater invertebrate acute toxicity study for parent pinoxaden to replace an unacceptable study Not specified 47293210 Satisfied 11/30/2007 5. Estuarine/marine fish acute toxicity test using parent pinoxaden to replace a supplemental study Not specified 47293210 Satisfied 11/30/2007 6. Estuarine/marine shrimp acute toxicity test is required using parent pinoxaden to replace a supplemental study. Not specified 47293201 Satisfied 11/30/2007 7. Freshwater fish early life-stage study using parent pinoxaden Not specified 47293210 Satisfied 11/30/2007 8. Freshwater invertebrate life-stage study required usinq pinoxaden not specified 47293210 Satisfied 11/30/2007 9. Avian dietary studies in mallard duck and bobwhite quail for the formulated product with adjuvant Not specified 47293210 Satisfied 11/30/2007 Pinoxaden RD 7/27/2005 10. Acute fish toxicity for the degradate NOA- 407854 on warm water species only, for the degradate NOA-447204 on warm water and cold water species, and for the formulated product with adjuvant on warm water and cold water species Not specified 47293210 Satisfied 11/30/2007 11. Freshwater invertebrate life-cycle studies for the degradate NOA-447204 and formulated product with adjuvant Not specified 47293210 Satisfied 11/30/2007 12. Marine-estuarine shell deposition studies for the deqradates NOA-407854 and NOA-447204. Not specified 47293210 Satisfied 11/30/2007 13. Freshwater fish early life-stage studies for the degradate NOA-407854, and the degradate NOA- 447204 Not specified 47293210 Satisfied 11/30/2007 14. Freshwater invertebrate life-cycle studies for the degradate NOA-447204, and for the degradate NOA -407854 to replace a supplemental study. not specified 47293210 Satisfied 11/30/2007 7/31/2018 12 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Re.: Notice Date MRID tor Studv Submitted Review Status Date Data Comments 15. Seedling emergence and vegetative vigor studies for each of the two main degradates NOA- 407854 and NOA-447204 Not specified 47293204, 47293205, 47293206 Satisfied 11/30/2007 16. Tier II Aquatic plant growth studies for the parent pinoxaden, degradates NOA-407854 and NOA-447204, and for the formulation with adjuvant Not specified 47293210 Satisfied 11/30/2007 17. 830 Series subgroup A required for the pinoxaden technical produced on a commerical scale. Not specified 46701301 Satisfied 11/30/2007 Prohexadione Calcium RD 4/26/2000 1. Storage stability on the processed commodities of peanuts 4/30/2001 45190501 waiver requested Waived 8/16/2000 Chem Satisfied 2. 21-day dermal toxicity study in rabbits 10/31/2001 45430301 Satisfied 6/18/2001 Propoxycarbazon e-sodium 1. Additional storage stability data for mustard greens and turnips to validate the submitted field rotational crop study 6/30/2006 46874601 Satisfied 6/30/2006 Chem Satisfied RD 6/30/2004 2. Study monitoring of "carboxylic acid" degradate to determine if it is accumulating in ponds, lakes and reseivoirs near propoxycarbazone use areas 6/30/2006 46365701 waiver request Waived 9/20/2004 waiver granted 4/26/2005 1. Developmental neurotoxicity study, brain morphometric measurements from the mid and low dose animals, also addressing the other deficiencies listed in the DER to allow the reconsideration of the FQPA database uncertainty factor 12/1/2007 47293901 Satisfied 12/3/2007 Chem Satisfied 2. Final report of the ongoing storage stability study with prothioconazole and desthioprothioconazole in plant commodities 3/31/2008 47408201 Satisfied 4/21/2008 3. Poultry feedinq study with prothioconazole 6/30/2008 47492801 Satisfied 7/30/2008 4.Data to confirm the degree of stability of the prothioconazole-4-hydroxy in ruminant fat for a duration of 45 days. 12/1/2007 47107801 Satisfied 4/17/2007 5. Analytical reference standards for the following compounds: prothioconazole-desthio, prothioconazole sulfonic acid potassium salt, prothioconazole 7/1/2007 N/A Satisfied 4/4/2007 Prothioconazole RD 3/27/2007 6. Raw data from field fortifications in MRID 46246447 (in addition to the percent conversions reported in the study) 12/1/2007 47337401 Satisfied 2/15/2008 7. Proposed data collection and enforcement methods for livestock commodities must be be validated for poultry commodities. The EPA labs validated the livestock method for liver and milk. If the poultry method is the same or essentially the same, then the registrant at a minimum must present an argument and confirm (in writing) that the cow liver LOQ covers chicken liver. At a max, the registrant must validate the method for poultry commodities, including a demonstration of the LOQs. 6/30/2008 47492801 Satisfied 7/30/2008 8. Repeat sediment toxicity study using chironomids following Agency guidelines in which the chemical is first added to the sediment 12/1/2007 47626901 Satisfied 12/17/2008 1. Anaerobic Soil Metabolism 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled Chem Cancelled 2. Anaerobic Aquatic Metabolism 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled PT807-HCI RD 12/30/1999 3. Aged Leaching 10/30/2001 N/A Cancelled N/A There are no active registrations. All registrations cancelled 4. Terrestrial Field Dissipation 6/30/2001 N/A Cancelled N/A There are no active registrations. All registrations cancelled 5. Developmental Rat Neurotoxicity study 12/30/2000 N/A Cancelled N/A There are no active registrations. All registrations cancelled 7/31/2018 13 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Re,; Notice Date MRIDfor Studv Submitted Review Status Date Data Comments Q/A notes 1 Received 1. Annually by December 31 of each year and beginning in 2003, report percent crop treated data for pyraclostrobin for each crop pyraclostrobin is sold for use on. Annually BASF submitted PCT data in December of each year, beginning in 2003 through 2010 Satisfied EPA informed BASF on March 23,2011 (via email) that PCT data is no longer required Chemical Pending or overdue 2. 2 year chronic toxicology study in rats must be submitted for female rats. The primary deficiency in the results for female rats in the study previously submitted is that the highest dose was well below the sub-chronic maximum dose and there were no significant treatment-related toxicoloqical effects. 9/30/2006 BASF submitted additional supporting data in 2/1/2002 in advance of the registration decision. 45596201 and 45596202-45596206 (supplemental information) Satisfied 2/1/2002 EPA upgraded study to acceptable for both male and female rats 9/10/2003 3. 18-month carcinogenicity study in mice must be submitted for female rats. The primary deficiency in the results for female mice in the study previously submitted is that the highest administered dose was well below the subchronic maximum tolerated dose and there were no significant systemic treatment-related toxicological effects of the dosing. 9/30/2006 46678201 Satisfied 10/27/2005 EPA report from CARC of 2/15/2007 indicates data requirement has been satisfied 4. 2 generation repro study in rats; primary deficiencies in the study previously submitted are that there were no adverse, treatment-related maternal, reproductive, or offspring effexts at the highest dose tested, and the limit dose was not approached. 9/30/2005 45596210 submitted in advance of the registration decision Satisfied 2/1/2002 Original study upgraded to acceptable in HIARC memo of 2/10/2003 5. 28-day dermal toxicity study in rats 9/30/2004 45596201 submitted in advance of the registration decision Satisfied 2/1/2002 Original study upgraded to acceptable in HIARC memo of 2/10/2003 6. 28-day inhalation study in rats 9/30/2004 46638801 Satisfied 9/6/2005 7. Aerobic aquatic metabolism study 9/30/2005 rebuttal submitted 45826701 Satisfied 12/18/2002 8. Acute aquatic toxicity of pyraclostrobin degradates BF 500-3 and BF 500-6 to freshwater fish 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed U 9. Acute aquatic toxicity of pyraclostrobin degradates BF 500-3 and BF 500-6 to freshwate invertebrates 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed U Pyraclostrobin RD 9/30/2007 10. Acute aquatic toxicity of pyraclostrobin degradates of BF 500-3 and BF 500-6 to freshwater qreen alqae 9/30/2005 46164001, 46164002, 46164003 Satisfied 12/29/2003 Waiver request requested and reviewed U 11. Acute toxicity of pyraclostrobin to sediment- dwelling organisms 9/30/2005 49080401, 49080402 (45826705, 46164003) Satisfied 3/11/13 (12/29/2003) EPA classified the studies that were received in 2003 as supplemental; new studies were received on 3/11/2013 12. Mysid life-cycle study 9/30/2005 1/31/2014 46227601 (supplemental); 49302901 Satisfied 1/23/2014; 3/17/2004 Satisfied - 49302901 Supplemental (46227601) 13. Avian acute toxicity study using the formulated product Headline EC 9/30/2005 45826702 Satisfied 12/18/2002 14. Fish acute toxicity study using the formulated product Headline EC 9/30/2005 4/1/2015 45826703, 45826704, 46164001/2/3 Satisfied 12/18/2002 Study was conducted according to OECD guidelines but classified as invalid in a review dated 2/10/2005. A waiver request was submitted on 8/29/2013. The waiver request was denied for the studies on the formulation but studies were submitted on the technical and are under review. Letter sent denying waiver and requesting a new study be submitted. New study due 4/1/2015. ??? Update received. Match received date to received date in comment? 15.Modify tolerance enforcement methods for determination of pyraclostrobin and it desmethoxy metabolite in or on plant commodities - the LC/MS/MS method D9808 and the HPLC/UV method D9904 to include any modifications made by the EPA laboratory during the Agency laboratory validation. within 3 months of BASF's receipt of the methods from the Agency 46710001 Satisfied 12/7/2005 ?? Due date 7/31/2018 14 of 18 ------- New Active Ingredient Registration Status 2000-2017 Division Re.: Notice Date Condition.il Data Reciuirementlsl 16.Modify tolerance enforcement methods for determination of residues of pyraclostrobin in or on ruminant commodities - the HPLC/UV metho 439/0 and the HPLC/UV method 446 to include any modifications made by the EPA laboratory durinq the Aqency laboratory validation. within 3 months of BASF's receipt of the methods from the Agency MRID tor Studv Submitted 46710001 Review Status Sstisfied Date Data 12/7/2005 Comments ?? Due date 17.Data to support storage conditions of milk and fat tissue samples from ruminant study 9/30/2004 45765401 Satisfied 9/25/2002 Supported HED memo - 7/26/2004 18. Study confirming that rotational crop samples were analyzed within the inteival represented by the storage stability study must be submitted. 9/30/2004 46469501 Satis ified 2/9/2005 1. Photolysis in water using pyraflufen-ethyl and all possible transformation products 12/31/2003 46162701, 46162702 Satisfied 12/31/2003 Chem Satisfied 2. Avian reproduction studies 12/31/2003 46447901 Satisfied 1/18/2005 Pyraflufen-ethyl RD 9/27/2002 3. Phototoxicity fish early life stage study using transformation product E-1 and transformation product E2. 12/31/2003 48409701 Satisfied 3/2/2011 4. 28-day Inhalation study 12/31/2003 48381204 Satisfied 2/10/2011 5. Preliminary analysis (830.1700) conducted in compliance with the GLP requirements of 40CFR160. 12/31/2003 46162701 Satisfied 12/31/2003 1. Storage stability and corrosion characteristics studies 8/9/2008 47309101 Satisfied 12/27/2007 Chem Satisfied 2. In vivo dermal penetration study 8/9/2009 47860001 Satisfied 9/27/2009 3. Revisions to the analytical methods 8/9/2009 47806401 Satisfied 7/17/2009 Pyrasulfotole RD 8/9/2007 4. Analytical reference standard for pyrasulfotole, pyrosulfotole-desmethyl and labeled internal standards to the EPA National Pesticide Standards Repository 8/9/2009 47806401 Satisfied 7/17/2009 5. Toxicity of residues in sediment to benthic orqanisms (freshwater and marine) 8/9/2009 47552401 Satisfied 9/29/2008 Pyridalyl RD 4/24/2008 1. Dissociation Constant No date specified 47664701 Satisfied 2/3/2009 Chem Satisfied Pyroxsulam RD 2/27/2008 1. One-year storage stability and corrosion characteristics studies 2/27/2009 47711901 Satisfied 3/25/2009 Chem Satisfied Saflufenacil RD 9/3/2009 1. Fish early life-stage toxicity with modified lighting for LDPH chemicals No date specified N/A Satisfied/ Waived N/A This is no longer a requirement for this chemical. Three ai's were chosen to submit the study, and this was not in that group. The data received supported EFED's earlier conclusions regarding LDPH phototoxicity, so no further information is needed on this topic for saflufenacil at this time. Chem In Review 2. Immunotoxicity study No date specified 48233701 Satisfied 10/14/2010 Acceptable; review completed 3/30/11 3. One year storage stability and corrosion characteristics No date specified 48212601 Satisfied 9/29/2010 4. 830 series group A data (including a revised basic CSF) for the BAS 800H TGAI/M UP when the product is produced on commercial scale No date specified 47913802 48445701 Satisfied 4/27/2010 1. Successful PMV of plant and livestock enforcement methods 3/28/2008 48875802 Satisfied 6/29/2012 Chem Satisfied 2. Poultry feedinq study 3/28/2009 47396302 Waiver requested Waived 4/9/2008 3. Processinq studies 9/28/2009 47453501 Satisfied 6/20/2008 4. Analytical reference standards 3/28/2008 48875802 Satis ified 6/29/2012 5. Acute freshwater invertebrate 6/28/2008 47359202, 47359203 Satisfied 2/29/2008 6. Oyster acute toxicity test (shell deposition) raw data or new study 6/28/2008 47359201 Satisfied 2/29/2008 Spinetoram RD 9/28/2007 7. Acute estaurine/marine fish 9/28/2009 47767601 Satisfied 6/3/2009 8. Acute freshwater fish 9/28/2008 47902003, 47902004 Satisfied 11/3/2009 9. Mysid chronic toxicity test 2/28/2009 47790501 Satisfied 6/30/2009 10. Whole sediment acute toxicity invertebrates, estuarine and freshwater 2/28/2009 47689701 Satisfied 2/27/2009 11. Honey bee toxicity of residues on foliaqe 2/28/2009 47689702 Satisfied 2/27/2009 12. 5-batch preliminary analysis data on this technical product produced on large or commercial scale, alonq with a revised CSF 12/31/2007 47306602, 47306603, 48085901 Satisfied 12/18/2017, 5/5/2010 7/31/2018 15 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Date Data 1. Details of the commercial scale production process for the TGAI/MUP for the facility located in Germany 6/30/2007 47024301 Satisfied 1/8/2007 Chem Satisfied 2. 5-batch analysis for the TGAI/MUP batches produced on a commercial scale, also submit a 6/30/2007 47024301 Satisfied 1/8/2007 revised basic formulation based on the 5-batches produced on a commercial scale 3. Apple (juice) and grape (juice) processing studies which monitor for residue of spirodiclofen 6/30/2007 47168602, 47168601 Satisfied 7/2/2007 Spirodiclofen RD 6/30/2005 4. Additional morphometric analyses of the caudate putamen, parietal cortex, hippocampal gyrus, and dentate gyrus at the mid and low doses are required for both sexes in the developmental neurotoxicity study 6/30/2007 47166501 Satisfied 6/28/2007 5. Repeated freshwater fish acute toxicity study usinq blueqill sunfish 6/30/2007 Waiver requested Waived N/A 6. Repeated freshwater fish acute toxicity study usinq rainbow trout 6/30/2007 Waiver requested Waived N/A 7. Repeated freshwater invertebrate toxicity study usinq daphnia maqna 6/30/2007 Waiver requested Waived N/A 8. Repeated estuarine/marine acute toxicity - sheepshead minnow 6/30/2007 Waiver requested Waived N/A 9. Repeated estuarine/marine acute toxicity - mysid shrimp 6/30/2007 Waiver requested Waived N/A 1. Additional storage stability data for rotational crops 11/3/2007 47293301 Satisfied 5/18/2007 Chem Pending or Overdue 2. Avian reproduction study using bobwhite quail and mallard duck 5/3/2007 47133101, 47142201 Satisfied 11/30/07, 5/31/07 Spiromesifen RD 5/3/2005 3. Chironomid sediment toxicity test 5/3/2007 47133102, 47133103 Satisfied 5/18/2007 4. Chronic field test for pollinators 5/3/2007 47344401 Satisfied 2/12/2008 Requirement satisfied with the supplemental study and polinator issue has been forwarded to the active Reg Review case for resolution. 5. Preliminary commercial scale 46825601 Satisfied 9/8/2006 1. New photodegradation on soil study, conducted on sterile soil 6/30/2009 47576501, 47576502 Satisfied 10/22/2008 Chem In Review 2. Soil taxonomy for the Saskatoon loam soil from Sasketchwan, Canada 12/30/2009 Letter Satisfied 1/1/2009 3. Avian reproduction study with the mallard duck 6/30/2010 48958801 Satisfied 5/11/2009, 10/11/2012 6/30/2008 10/15/2010 4. Field testing for pollinators 6/30/2010 47576401, 47563302, 47563303, 47563304, 47563305, 47563306, 47563307, 47563308, 47563309, 47563310, 47563311, 47563312 Satis ifed 10/22/2008 (first 2), 10/7/2008 (the rest) Spirotetramat RD 5. Freshwater fish toxicity with fathead minnows 6/30/2009 47774301 Satisfied 6/10/2009 6. Avian oral toxicity study with passerine species 6/30/2009 47774302 Satisfied 6/10/2009 7. One-year storage stability and corrosion characteristic studies 6/30/2009 48002901 Satisfied 3/3/2010 8. Full scale five-batch preliminary analysis of the technical material 6/30/2009 48525902, 4852903, 48525904 Satisfied 7/1/2011 9. Avian Reproduction with Mallard Duck (required in 10/15/2010 decision) 5/15/2011 48958801 Satisfied 10/11/2012 lO.lmmunotoxicity (required in 10/15/2010 decision) 10/15/2011 48525901 Satisfied 7/1/2001 11. Subchronic neurotoxicity (required in 10/15/2010 decision) 10/15/2011 48958802 Satisfied 10/11/2012 1. Modify the confirmatory method to use more than single-ion monitoring or conduct an interference study 7/31/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Chem Cancelled 2. Storage and stability data for the hops trials which were conducted in Germany 12/31/2004 N/A Cancelled N/A Products cancelled 5/23/2012. 2a. Storage stability for bananas frozen for 6 months 12/31/2004 N/A Cancelled N/A Products cancelled 5/23/2012. 7/31/2018 16 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemical Division Date Data Spiroxamine RD 7/16/2004 3. Two-Generation Reproduction Study-Rat (Additional data to clarify lactation indices and clinical signs of toxicity in the second generation in the submitted study (if data is insufficient to upgrade study, a new two-generation reproduction study must be submitted with any future new uses) 12/30/2004 N/A Cancelled N/A Products cancelled 5/23/2012. 4. Adsorption/Desorption study with soils from hop-qrowinq areas 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. 5. Freshwater fish (Blueqill sunfish)-Acute 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. 6. Freshwater fish rainbow trout-Acute 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. 7. Aquatic plant growth (conducted at maximum seasonal use rate) 9/30/2005 N/A Cancelled N/A Products cancelled 5/23/2012. Tebufenpyrad RD 8/26/2002 1. 90-day inhalation study Cancelled Cancelled 1. 28-day Inhalation Study 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. Chem Cancelled 2. Developmental neurotoxicity study 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. 3. Residue data on soybean aspirated grain fractions (qrain dust) 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. Tepraloxydim RD 8/8/2001 4. Aerobic aquatic metabolism study 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. 5. Leaching adsorption/desorption-mobility of aqed residues 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. 6. Photolysis in water 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. 7. Terrestrial field dissipation studies 8/8/2005 N/A Cancelled N/A Voluntarily cancelled. Tetraconazole RD 4/14/2005 1. Single side-by-side sugar beet field trial comparing two and six applications of Eminent 125SI at 0.10 lb ai/acre/application. The retreatment internals for the plot receiving six applications should be 14 days and the RTI for the plot receiving two applications should be 21 days (the final application and haivest dates for each should be identical; preharvest inteival (PHI) of 14 days; 4 samples from each plot should be collected 5/1/2007 47111401 Satisfied 4/23/2007 Chem Satisfied 2. 28-day inhalation study based on the current use pattern 2/1/2007 46990301 Satisfied 11/21/2006 3. Study determining toxicity to benthic organisms (includinq chronomid) 1/1/2006 46614304 Satisfied 8/2/2005 4. Study determininq the toxicity to earthworms 12/1/2006 46614305, 46614306 Satisfied 8/2/2005 5. New quideline adsorption/desorption study 11/1/2006 47023201 Satisfied 1/8/2007 1. Confirmatory procedure for the livestock tissue analytical enforcement method 3/26/2004 waiver requested Waived 1/14/2004 Waiver granted 12/16/04 Chem Satisfied 2. Photodeqration in soil 9/26/2004 44927933 Satisfied 4/28/2004 Found to be acceptable 6/16/04 3. One year storaqe stability 9/26/2005 46462301 Satisfied 2/4/2005 Found to be acceptable 9/23/05 4. Corrosion characteristics 9/26/2005 46462301 Satisfied 2/4/2005 Found to be acceptable 9/23/05 Thiacloprid RD 9/26/2003 5. Bioaccumulation in fish 9/26/2005 44927602 waiver requested Waived 6/8/2004 MRID submitted supported waiver request which was qranted on 8/3/04 6. Limited field accumulation studies in rotational crops for wheat and soybeans 9/26/2007 46677901, 46677902 Waived 10/28/2005 7. Five batch analysis When commercial batches available 46677905 Satisfied 10/28/2005 1. Modification of Method AG-675 to add microwave extraction of liver or a new enforcement method for liver, additional radiovalidation data for beef liver 3/4/2002 45659202, 45659203 Satisfied 4/23/2002 Chem Satisfied 2. Storage stability data continued to cover the conditions and internals that plant and animal commodity samples were stored (up to 30 months) 3/4/2002 45659204, 45659205 Satisfied 4/23/2002 Thiamethoxam RD 12/4/2000 3. Reanalysis of the cow liver samples from the feedinq study usinq a microwave extraction step 3/4/2002 45659206 Satisfied 4/23/2002 4. Reanalysis of field rotational crop samples for metabolite CGA-265307 and description of storaqe conditions for future uses 3/4/2002 45659201 Satisfied 4/23/2002 5. Plant metabolism study on a leafy vegetable (Crop qroup 4 or 5) 3/4/2002 45093714 Satisfied 3/31/2000 6. Poultry metabolism study 3/4/2002 44703526, 44715115 Satisfied 11/19/1998, 12/10/1998 7/31/2018 17 of 18 ------- New Active Ingredient Registration Status 2000-2017 Chemic.il Division fie.: Notice D»itc 7. Developmental neurotoxicity study 12/4/2002 46028201, 46028202 Satisfied 7/3/2003 8. Repeated daphnia chronic study 12/4/2002 45500001 Satisfied 9/19/2001 1. 90-day dermal toxicity study in rat, storage stability, corrosion characteristics 7/28/2011 482334021, 482334022 Satisfied 9/20/2010 Chem Satisfied Tolfenpyrad RD 7/28/2010 2. For prod. chem. review, submit analytical method as described in MRIDs 47447704 and 47447705, and samples to EPA lab for validation 7/28/2011 48660301 Satisfied 9/20/2010 1.Aerobic aquatic metabolism 7/31/2008 47496702 Satisfied 8/1/2008 Status? 2. Anaerobic Aquatic Metabolism 7/31/2008 47496703 Satisfied 8/1/2008 3. Mobility in Soils 7/31/2008 45902425, 46242703 Satisfied 3/28/2003, 4/6/2004 4. Frozen Storage Stability 7/31/2008 47496704, 47496705, 47496708 Satisfied 8/1/2008 5. Avian Subacute Dietary 7/31/2008 47496708, 47496707 Satisfied 8/1/2008 6. Avian Reproduction 7/31/2008 47496708, 47496707 Satisfied 8/1/2008 7. Aquatic Invertebrate Life-cycle 7/31/2008 47496707 Satisfied 8/1/2008 8. Aquatic Plant Growth (Tier II) (Navicula) 7/31/2008 48600403 Satisfied 3/2/2012 9. Seedlinq Emerqence (Tier II) 7/31/2008 45902327 Satisfied 3/28/2003 Topramezone RD 8/10/2005 10. Veqetative Viqor (Tier II) 7/31/2008 45902328 Satisfied 3/28/2003 (BAS 670H) 11. Adequate storage stability data in the plant and livestock metabolism studies by 7/31/2008 7/31/2008 45902410 Satisfied 3/28/2003 submitted as part of the original registration application and included in HED's residue chemistry chapter. Study acceptable 5/27/05 (DP310772). Should not have been included in the conditional requirements. Per Kay 12. 5-batch analysis 7/31/2008 47496701 Satisfied 8/1/2008 1. TLC scans for initial qrape extracts 12/1/2001 454614402 45461403 Satis ified 7/25/2001 Chemical Satisfied 2. Substitution of derivatizing agent in the residue analytical method 12/1/2001 45437801; 45437802 Satisfied 6/25/2001 3. Incorporate changes resulting from method review 12/1/2001 Rebuttal to review sumbitted Satisfied 4. Protocol first then pulmonary sensitization study 12/1/2001 45568300 Waiver requested Waived 5. Storage stability data for the grape processing study 12/1/2001 45461402, 45461403 Satisfied 7/25/2001 Zoxamide RD 4/11/2001 6. Product stewardship plan for monitoring and recording incidents related to inhalation and dermal sensitization. Biannual reports required, 12/1/2001 N/A Satisfied N/A Report received; no inicidents reported; no longer required. 7. Full scale production data including 5 batch analysis 12/1/2001 45568301; 45568302 Satisfied 12/20/2001 8. Resistance monitoring data for potatoes 12/1/2001 45568303; 45568304; 45568305 Satisfied 12/20/2001 Submitted as part of harmonization effort with PMRA. BEAD determined data no lonqer needed. 9. Proximity information of endangered, threatened freshwater fish and estuaring/marine invertebrates to use sites 12/1/2001 Waiver requested Waived 12/20/2001 Registrant is member of Endangered Species Task Force 7/31/2018 18 of 18 ------- |