ECOTOX Knowledgebase ReferenceGuide
United States
Igen?ymental Protection EPA/600/F-19/089
General Guidance on Searches / Navigation / Explore / Help:
o The "Search" function is designed to query the data if the exact search parameters are known. Data can be refined by selecting additional
search parameters. It is recommended that you conduct general searches initially, and filter or refine output if the data set is too large,
o The "Explore" function allows you to search ECOTOX if the exact parameters you want to search are not known, or you would like a
visual representation of the data. This is a great starting point for filtering the data prior to running a search,
o The search logic includes two basic strategies, combination/union and intersection. Within a search selection box, the selections are
combined. Between search selection boxes, the search will intersect.
o Context sensitive help is available by clicking on the  located within the Chemical, Effects, Species and Publication search parameters,
o Using your browser's Back button will result in the loss of all entries made in any of the ECOTOX forms,
o The Help function contains complete User guide and a Code Definition document.
o Researchers or managers using ECOTOX for analyses or summary projects should consult the original scientific paper to ensure
an understanding of the context of the data retrieved.
About Search
The "Search" function is located within a single web page. Click on the
plus sign next to each Search parameter to select or enter specific
Search parameters (you must select at least one parameter):
All Chemicals (Chemical names, CAS Registry numbers or
predefined groups)
All Effects (Search specific measurements or select major effect
groups from a predefined list)
All Endpoints (Select all or any endpoints, or statistics but no
endpoint or endpoint is not reported)
All Species (Select taxonomic kingdom, scientific or common
names, or predefined groups)
All Test Conditions (Select any or all lab/field studies, exposure
or control media and types, and chemical analysis methods)
All Publication Options (Search by year, author, datasets or
specific ECOTOX data updates)
Any selections made using multiple parameter search boxes within the
search page will narrow the search result.
Perform a search (Update Search): Once all parameters are selected
or entered, click the "Update Search" button to apply the selection
parameters and perform the search. Aquatic and Terrestrial reports are
run separately. The output table defaults to show Aquatic data first; click
on Terrestrial tab to show relevant data. Clicking to select the other
habitat will automatically run that search provided no other changes
were made to search parameters. Customizing output fields must be
done to each habitat to update data reported.
< Chemicals
Q, Name(s) or CAS number(s)
O Contains	Q Exact Match
Enter each chemical name and/or CAS registry number on separate lines.
< Effect Measurements
Qv Effect(s) (eg. food, vitellogenini, acetylcholine)
O Contains	Q Exact Match
Enter each effect measurement on separate lines.
I I Include Delayed Effects Results
D Any Effect Group
Accumulation Group
Behavior Group
El Avoidance
_| Behavior
Feeding Behavior
Growth Group
_| Developmental
_| Growth
_| Morphological
Mortality Group
Update Search
Aquatic	Terrestrial
Reports: All results initially display in HTML format. You can choose to
export the report after the results are retrieved by selecting the "Export
as..." button. Excel and delimited reports are available for selection.
0 Export as...
Reset All: Clears all Search parameters.
x Reset All
View All Applied: View the selected parameters, which can be
exported to retain a record of the search.
View All Applied
For more information on the ECOTOX Knowledgebase: Telephone: 218 529 5225 Email:

United States
Environmental Protection
ECOTOX Knowledgebase ReferenceGuide EPA/600/F-xxx
About Explore
Choose a storting point betow.
Explore is a great tool for searching the ECOTOX Knowledgebase if you do not
know the exact parameters you want to search, or would like a visual
representation of general and specific data trends. It provides an interactive
way to examine search paths by Chemicals, Species or Effects. The data can
be visually examined with interactive plots.
Searching in Explore is predominately driven by selecting predefined groups
within each of the Chemicals, Species, and Effects pages. Within the Chemicals
and Species pages, users are also able to customize queries by entering in
CAS Registry Numbers, NCBI TaxIDs or typing list of species keywords to
Querying and Filtering Data:
To query the data, start by selecting the parameter of interest (Chemicals,
Species or Effects). Select from the predefined lists, or create custom group,
then click "Explore Data".
Explore Data >
From the tables displayed for the 'Group Summary' or 'Records', you can
further refine the data by applying Query filters (refine data to select one or
more names or options using control/click to highlight) or selecting to
include/exclude Aquatic or Terrestrial habitats. The following Query filter
options and associated data are available utilizing the drop-down feature for:
Species Group
Special Interest Groups
Effect Groups
Effect Measurements
Publication Years
Interactive Data Display:
Once a query has been run, the data can be plotted and output refined
further using the Query filters mentioned above. After the query is run, you
can toggle between various features (Group Summary, Records and Plot
View. The pre-defined options for these plots have Chemical
concentration on the y-axis and either Effect Group or Exposure Duration
on the x-axis. Zooming into data is available using concentration range
bar below plot.
	Data records can be plotted if they can be converted to standardized
concentration units (ppm).
	In the simplified Results Table below plot, data can be refined using text
boxes above each column.
	Clicking on 'Group Summary' or 'Records' tab will return data to table
	Both tabular data and plot can be exported and saved.
Species Group
Special Interest Groups
Effect Groups
Effect Measurements
Publication Years
Group Summary
Plot View
0 Export v
Table as CSV
Print Chart
For more information on the ECOTOX Knowledgebase: Telephone: 218 529 5225 Email: