SEPA
EPA Document # 740B19008
Date August 9,2019
Unites States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Approach Document for Screening Hazard Information for
Low-Priority Substances
Under TSCA
August 2019

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Table of Contents
1.	General Process	5
2.	Data Search	7
2.1	Chemical Identification	7
2.2	Literature Search Strategy	7
2.3	Search Execution, Retrieval or Results, and Storage in HERO	9
3.	Data Screening and Evaluation	10
3.1	Information Needs and Criteria	10
3.2	Initial Screening by Title and Abstract	10
3.3	Full-Text Screening	11
3.4	Data Evaluation	11
4.	Data Extraction and Integration	13
4.1	Data Extraction	13
4.2	Data Integration into Summary Findings	13
Appendix A: Information Needs	15
Appendix B: Title/Abstract Screening Questions	17
Appendix C: Full-Text Screening Questions in DistillerSR	19
Appendix D: Data Quality Metrics	24

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List of Figures
Figure 1: General approach to gather, screen, evaluate, extract and integrate relevant information for low-

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List of Tables
Table 1: Peer-reviewed Databases Searched for Low-Priority Substance Candidates		8
Table 2: Grey Literature and Additional Sources Searched for Low-Priority Substance Candidates		8
Table 3: Data Quality Evaluation Domains and Metrics by Discipline		12
Table A.1: Information Needs for Health Hazard Data		15
Table A.2: Information Needs for Environmental Hazard Data		16
Table A.3: Information Needs for Fate Data		16
Table B.1: Low-Priority Substance Title/Abstract Screening Questions for Health Hazard Data		17
Table B.2: Low-Priority Substance Title/Abstract Screening Questions for Environmental Hazard Data		18
Table B.3: Low-Priority Substance Title/Abstract Screening Questions for Fate Data		18
Table C.1: Low-Priority Substance Full-Text Screening Questions for Health Hazard Data		19
Table C.2: Low-Priority Substance Full-Text Screening Questions for Environmental Hazard Data		21
Table C.3: Low-Priority Substance Full-Text Screening Questions for Fate Data		22
Table D. 1: Low-Priority Substance Data Quality Evaluation of Health Hazard -Animal Data		24
Table D.2: Low-Priority Substance Data Quality Evaluation of Health Hazard -in vitro Data		26
Table D.3: Low-Priority Substance Data Quality Evaluation of Environmental Hazard Data		29
Table D.4: Low-Priority Substance Data Quality Evaluation of Fate Data		31

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Figure 1: General approach to gather, screen, evaluate, extract and integrate information sufficient
to establish designation for low-priority substances
Search of peer-reviewed sources in HERO
Title/abstract screening in DistillerSR
Full text screening in DistillerSR
Full text screening in DistillerSR
Title/abstract screening outside of DistillerSR
Data integration
Unacceptable references
excluded at data quality
evaluation
Off-topic references
excluded at full text
screening
Off-topic references
excluded at title/abstract
screening
Summary of findings for low-priority designation
On-topic references tagged and PDF/URL retrieved in
HERO
On-topic references tagged in HERO and manually
imported into DistillerSR
Search of grey literature and additional sources
outside HERO
Data evaluation in DistillerSR
Two outcomes: Acceptable or Unacceptable
Data extraction in Access Database
Extraction of study details and results of acceptable, on-topic
references

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