Unhid Sttta
Environmental Protection
Agancy
S^O I f:'S- ?"!- CU'-I
Offioa of PwtkidM and Toxic S«tetane« ^ I ^CI
Offica of Particida Programs (TS-766C)
Washington, DC 20460
&EPA Pesticide
Fact Sheet
Name of Chemical: Fluometuron
Reason for Issuance: Re8istration Standard
Date Issued: December 1985
Fact Sheet Number: 88
1. Description of chqplcal
Generic name: FLOCMETURON (ANSI, VSSA, BSI, ISO)
Trade name: Cotoran®, Lanex*
EPA Shaughnessy code: 035503
Chemical Abstracts Service (CAS) nunber: 216*4-17-2
Year of Initial registration: I960
Pesticide type: Herbicide
Chenlcal family: Substituted urea
U.S. and foreign producers: Clba-Gelgy, FBC Chemicals
• 2. Use patterns and formulations
Application sites: To selectively control certain annual grasses and
broadleaf weeds in cotton and sugarcane.
Formulations: Flowable liquid concentrate and wettable pcwder.
Types and methods of application: Postemergent directed or over-the-top
spray, preplant soil Incorporated, preemergent broadcast or banded
spray, a directed layby treatment, and aerial application.
Application rates: Cotton 1.0 to 2.0 pounds of active Ingredient per acre
with one to three applications per season, sugarcane 2.0 to *J.O pounds of
active Ingredient per acre with one to two applications per season.
3. Science findings
Sumnary science statanent: Flucmeturon has been found to have many
data gaps and to be a potential ground water contaminant.

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2
Fluometuron Is not acutely toxic in general, however, it
does produce some skin irritation and does Induce corneal
opacity.
Chemical Characteristics:
Physical State: Powder or crystals
Color: White to tan
Odor: sAmlne-like
Melting Point: ;163 to 164.5
.Specific Gravity t>r Drtislty: 1.40 ®/cm3 § 20 °C
Solubility	Solvent	20 °C
Water	105 ppm
Acetone	15X
Chloroform 2f
Methanol	14%
Hexane	< 4%
Vapor Pressure: 5 x 10 mmHg # 20 °C
Octanol/Water Partition Coefficient: PK ¦ 3*2 € 20 °C
Stability: Rydrolyzed by acid or base. Stable at room
temperature.
Toxicological Characteristics.*
Acute Effects:
Acute Oral Toxicity: 8.9 go/kg male rats
7.8 gm/kg female rats
Toxicity Category IV
Acute Dermal Toxicity: 3*03 gm/kg rabbits
Toxicity Category III
Acute Inhalation: > 2.07 mg/L
Toxicity Category III
Primary Eye Irritation: Induces corneal opacity.
Toxicity Category: I
Major Routes of Exposure: Dermal, inhalation
Subchronic Effects:

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The NOEL for rats is 7.5 rag/kg
The NOEL for dogs Is 400 ppm
Chronic Effects:
No adequate feeding studies are available to establish
the chronic toxicity potential of technical Fluometuron.
Oncogenicity: Data gap
Teratogenicity: The compound Is not teratogenic up to 300
mg/Jcg- Ko LeL can t>e established based
ton current1 data.
2-0eneratlon "Reproduction: Data Qap
Mutagenicity: Data Qap
Physiological and Biochemical Behavioral Characteristics:
Metabolism: Data Gap
Environmental Characteristics:
Preliminary Adsorption and Leaching Characteristics:
Pluometuron is moderately to very mobile in a variety
of soils ranging in texture from sand to sllty clay loam.
These characteristics are not adequately understood.
Resultant Average Persistence:
«
Fluometuron dissipates in sandy clay loam with a half-
life of < 30 days (Europe).
Ecological Characteristics:
Hazards to Birds:
Data are sufficient to characterise fluometuron
as slightly to practically nontoxic to birds.
Hazards to Pish: Data Oap
Tolerance Assessment:
List of Crops and Tolerances: (CPR 40 1R0.229)
Commodity	ppm
Cottonseed	0.1
Sugarcane	0.1

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Results of Tolerance Assessment:
Tolerances cannot be adequately assessed until data gaps
have been filled.
Summary of Regulatory Position and Rationale:
Based on review and evaluation of all available data and
other relevant Information on fluometuron, the agency has
made the following determinations:
The available data are Insufficient to Indicate that
any'of the rlak .-criteria 11«ted *ln 5 162.11(a) of
title 40 of the U.S. Code of Federal Regulations have
-been met or exceeded for the uses of fluometuron at
the present time.
Fluometuron Is a toxicity category I chemical regarding
corneal opacity. Skin Irritation places fluometuron
In toxicity category II. However the agency has determined
that the protective clothing required by this standard
will sufflcantly reduce the risk associated with its use.
The absence of other toxlcologlcal data prevents the
agency from determining the subacute and chronic
effects of fluometuron. Olven the lack of data, the
most appropriate action Is to move quickly to fill
the data gaps. When data are submitted and reviewed,
the agency will determine the reglsterablllty of the
affected use pattern.
Fluometuron tolerances for cotton and sugarcane will
be reevaluated when the requested data In the standard
are received and reviewed. The data base supporting
these tolerances is Inadequate. The data required to
fill these data gaps are listed under number 6, Summary
of Major Data Qaps, on this fact sheet.
Tolerances for fluometuron on meat, milk, poultry,
and eggs have not been established therefore the label
restrictions on feeding crop material to livestock
will remain on product labeling.
Fluometuron has been placed on the list of possible
ground water contaminants and the Agency has requested
ground water data on an accelerated basis under the
data-call-in program.

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5
Use, Formulation or Geographic Restrictions:
Manufacturing-use products may only be formulated into
end-use products intended for use as an herbicide on
cotton and sugarcane.
5« Unique Label Warning Statements:
Labels of all MPs must bear the statement:
Use Pattern Statements
For formulation ilnto end-use herbicide-products
Intended for mse ion cotton and sugarcane.
Precautionary Statements
Do not contaminate water by cleaning of
equipment or disposal of wastes.
Do not discharge effluent containing this
product Into lakes, streams, ponds, estuaries,
oceans, or public waters unless this product
Is specifically identified and addressed in
an NPDES permit. Do not discharge effluent
containing this product Into sewer systems
without previously notifying the sewage treat-
ment plant authority. For guidance contact
your State Water Board or regional office of EPA.
Labels of EPs must bear the statements:
«
Hazards to Humans Statements:
Mixer/loader/applicators must wear pro-
tective clothing, consisting of coveralls,
a long-sleeved shirt, shoes, Impermeable
gloves, and eye protection when handling
this product.

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6
Environmental Hazard Statements:
The labels of F.Ps intended for outdoor
use must bear one of the following state-
Bents , depending on the formulation of the
product.
Granular products oust bear the statement:
Do not apply directly to water or wetlands.
In case of spills, collect for use or
properly dispose of the granules. Do not
.contaminate -water 'by cleaning of -equlpoent
or disposal of wastes.
Nongranular products oust bear tbe statement:
Do not apply directly to water or wetlands.
Do not contaainate water by cleaning of
equipment or disposal of wastes.
All products registered for use on:
Cotton:
Do not feed foliage from treated cotton
plants or gin trash to livestock.
Do not apply within 60 days of cotton harvest.
Sugarcane:
Do not apply within 180 days of harvest.
Do not graze treated fields with livestock.
All Products Phytotoxicity Warnings:
Do not plant crops other thpn sugarcane or
cotton within one year after the last appli-
cation or crop injury nay result.
6. Summary of Major Data Gaps:
Dates when major data gaps are due to be filled.

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Data Requested
Date Due
Product Chemistry
Magnitude of the Residues
Sugarcane
Magnitude of the Residues
Cotton
Nature of flesldue
(Metabolism)
Hydrolysis
Pho tod eg r ada t Ion
Water
Soli
Metabolism-lab
Aerobic Soli
Anaerobic Soil
Leaching and Adsorption/
Desorption
Soli Dissipation Field
Accumulation, Rotational
Cropa
21-Day Dermal
Chronic Toxicity
Oncogenicity Study
Teratogenicity
Reproduction
Oene Mutation
(After Issuance of the
Standard)
7 Months
19 Months
19 Months
25 Months
Study under review
Study under review
Study under review
Study under review
Study under review
Study under review
Study under review
Study under review
13 Months
50 Months
50 Months
15 Months
39 Months
9 Months

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R
Data Requested (cont.)
Chromosal Aberration
Other Mechanisms of
Mutagenicity
General Metabolism
Preshwater Pish
Warnwater
yvOllmr Jdaalpatlon
Soil Dissipation
Dermal Exposure
Inhalation Exposure
Analytical Methods to
Verify Certified Units
Submittal of Samples	7 Months
Dermal Sensitization and	9 Months
Photosensltlzatlon
7. Contact Person at EPA;
Robert J. Taylor
U.S. Environmental Protection Agency
TS-767-C
HOI M Street SV.
Washington, DC 20460
(703) 557-1800
DISCLAIMER:
The information presented in this Chemical Information Pact
Sheet Is for Informational purposes only and may not be used to
fulfill data requirements for pesticide registration and
reregistration.
Date Due (cont.)
12 Months
12	Months
2k Months
9 Months
25 ("Months
25 Months
25 Months
25 Months
13	Months

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