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Environmsntal Prd taction Offlc* of PMiddt ISugixm (TS-768C)
Agency WMtfawton. DC 20460
540/FS-88-123
vvEPA Pesticide
Fact Sheet
Name of Chemical: bendiocarb
Reason for Issuance: registration standard
Date Issued: june, 198 7
Fact Sheet Number: 195
1. Descriotion of chemical
Common Wane: Bendiocarb
Chemical Name; 2 , 2-d ime t hy 1 - 1 , 3 - ben zoo 1 o:
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Jingle active ingredieht formulations consist of 0.5 and
1.0% Dusts, 2.5 and 5.0% Granulars, 20 and 76% Wettable Powders,
1% Wetttable Powders/Dusts, 0.03175, 0.38 and 0.45% Impregnated
Shelf Paper, 2.64 lb/gal Flowable Concentrates, 1.67 and 2 lb/gal
Soluble Concentrates/Liquids, and 1.5 and 2 lb/gal Ready To Use,
"Bendiocarb is generally applied by' broadcast or directed
spray using ground equipment. Application of the 5% Granulars,
76% Wettable Powders, 2.64 lb/gal Flowable Concentrates, the
1.67 and 2 lb/gal Soluble Concentrates/Liquids, and the 1.5
and 2 lb/gal Heady To Use formulations is recommended for use
by Pest Control Operators only.
3 . Science Findings
Chemical Characteristics
Color: White (Crystalline)
Odor: Odorless to very slight odor
Melting point: 129-130 C
Bulk Density: 0.52 g/ml (loose), 0.62 g/ml (compacted),
Vapor Pressure: 5.0 x 10-^ mm Hg at 25°C
Stability: Chemically stable during 16 months storage at
40°C in sealed containers. No thermal breakdown
at temperatu'res of up to 100°C
Solubility: Very slightly soluble in water and kerosene,
highly soluble in nonpolar organic solvents.
Toxicology Characteristics
Acute oral (rats): 45-48 mg/kg (male) (Toxicity Category I)
34-40 mg/kg (female)
Acute dermal (rats): 566 mg/kg (Toxicity Category II)
Acute inhalation: Data not available
Primary eye irritation: Slight' (Toxicity Category III)
Primary skin irritation: Mild (Toxicity Category III)
Skin sensitization: Not a skin sensitizer
Subchronic oral: No Observed Effect Level (NOEL) - 0.5 mg/kg/day
for cholinesterase inhibition
Subchronic dermal: NOEL = 50 mg/kg/day for 80W formulated product
Chronic effects: Hat: NOEL = 0.5 mg/kg/day; effects noted were
cholinesterase inhibition and increased lenti-
cular opacity
Dog: NOEL = 2.5 mg/kg/day; cholinesterase
inhibition was the only effect noted
Oncogenicity: No evidence of oncogenic effects
Teratogenicity: Not a teratogen
Heproductive effects: Does not exhibit reproductive effects
Mutagenicity: Data not available
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Physiological and Biochew i C al Character i s t ic_s
Metabolism: Bendiocarb is rapidly absorbed from the intestine
and excreted primarily in urine. Little excretion
occurs via the feces. The principal metabolite
is the hydrolysis product of bendiocarb (NC-7312) .
Bendiocarb was not stored in organ tissues.
Dermal absorption: 53-64% on occluded skin in humans
8-16% on non-occluded skin in humans
Environmental Characteristics
Data are generally not available to evaluate the environmental
fate of bendiocarb
Ecoloqical Characteristics
Avian acute toxicity: 3.1 mg/kg (mallard duck)
19 mg/kg (bobwhite guail)
Avian subacute toxicity: 477 ppm in the diet_ (mallard duck)
1770 ppm in the diety (bobwhite quail)
Avian reproduction: Reproductive impairment may occur when
used on turf
Freshwater fish acute toxicity: 1.2-1.5 ppm (trout)
0.47-1.67 ppm (bluegill sunfish)
Freshwater invertebrates: 29.2 ppm (Daphnia magna)
Estuarine and marine organisms: Data not available
Honey bees: Highly toxic
Tolerance Assessment
Bendiocarb is not currently used on agricultural co;r\mod 111 es.
Therefore, no residue tolerances have been established for
food crop;;, processed foods, or animals and animal byproducts.
No numerical lood or feed additive tolerances have been
established for residues of bendiocarb in food/feed resulting
from its use in Lood handling and animal feed handling estab-
lishments. However, the prescribed condit ions for use of
bendiocarb in these sites are set out in 21 CFR 193.132 and
21 CFR 561 . 19] .
No tolerances or exemptions from the requirement of tolerances
have been established for residues of bendiocarb in or on
agricultural commodities. Request's for tolerance are currently
pending for a number of crops.
No tolerances or exemptions from the requirement of tolerances
for bendiocarb residues in animal commodities exist. .
Animal metabolism and residue data submitted in support of
proposed tolerances are currently under review; therefore,
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no conclusions 'regarding the nature Of the. residue in animals
will be made at this time.
No Canadian or Mexican tolerance or Codex MRL (Maximum Residue
Levels) related to uses of bendiocarb in food handlinq establish-
ments have been established.
1 Summary of Regulatory Positions and Rationales
--Bendiocarb will not be put into Special Review at this
time. Potential risks to avian and aquatic species must
be evaluated based on actual residue monitoring and field
studies.
- - Bend 1 ocarb use on commercial turf is restricted to use
by certified applicators due to avian and aquatic, toxicity.
--Reentry intervals are. not being established for turf and
ornamental uses of bendiocarb-
--endangered species labeling statements are required for
the mosquito adulticide and turf uses
--Food additive tolerances are reguired for processed food
and feed resulting from application in food/feed processing
areas, and for residues, resulting in food fro.Ti use in
shelf paper.
5. Summary of Outstandinq Data Requirements Approximate
Time Frame
6-15 months
4 3 months
4 3 months
12 months
9-27 months
2 7 months
12 months
9 months
15 months
9-12 months
Product Chemistry Data
Residue Chemistry Data
17 1-4 - Residue analytical
17 1-4 Storage stability data
171-4 - Magnitude of the Residue -
Processed foods commercial
food/feed handling estab.
Knvii oninenta 1 rate Studies
Reentiy Data
13 2-1 - Foliar Dissipation
Spray Drift Studios
To xlc o1og y
81-3 Acute Inhalation - Rat
.82-1 90-Dav Inhalation - Rat
84-2 Mutagenicity studies
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Wildlife and Aquatic Organisms
70-1
- Aquatic Residue Monitoring
43
months
71-S
- Actual Field Testing for Mammals
48
months
and Birds
72-3
- Estuarine & Marine Organism Acute
LC53 12
months
72-4
- Fish Early Life-Stage and
Aquatic Invertebrate Life Cycle
15
months
72-6
- Aquatic Organism Accumulation
12
•months
Nontarget Insect
141-2 - Honey bee - toxicity of residues
on foliage 15 months
F. Contact Person
Dennis H- Edwards
Product Manager 12
Insecticide-Rodenticide Branch
Registration Division (TS-767C)
401 M St-, S.W.
Washington, DC 20460
Tel: 703-557-2336
DISCLAIMER;
THE INFORMATION PRESENTED IN THIS CHEMICAL INFORMATION FACT
SHEET IS FOR INFORMATIONAL PURPOSES ONLY AND NOT TO BE USED
TO FULFILL DATA REQUIREMENTS FOR PESTICIDE REGISTRATION AND
REREG ISTRATION.
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