PEER REVIEW DRAFT - DO NOT CITE OR QUOTE United States Environmental Protection Agency Office of Chemical Safety and Pollution Prevention Draft Risk Evaluation for 1-Bromopropane (1-BP) 1-BP Systematic Review Supplemental File: Data Extraction for Consumer Exposure CASRN: 106-94-5 CH August 2019 NOTICE: This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Biomonitoring Data for 1-BP using the one article in Systematic Review Systematic review identified biomonitoring measurements from only one source, the National Health and Nutrition Examination Survey (NHANES), conducted by CDC's National Center for Health Statistics (NCHS). The survey is "a complex, stratified, multistage, probability-cluster design survey" designed to collect data on the health and nutrition of a representative sample of the US population. NHANES measured the metabolite Acetyl-S-(n-propyl)-L-cysteine (BPMA) in urine spot samples. Jain et. al. (2015) investigated the variability of BPMA levels in children aged 6-11 years for the 2011-2012 NHANES survey cycle. The geometric mean concentration (with 95% confidence intervals) in urine was 2.6 (2-3.3) |ig/L for males (n=203) and 3.3 (2.5- 4.3) |ig/L for females (n=214). CDC published in Jan 2019 their 4th report with data through the 2016 cycle, which incorporates data from 2011-2012. So alternatively, can use this paragraph. Systematic review identified biomonitoring measurements from only one source, the National Health and Nutrition Examination Survey (NHANES), conducted by CDC's National Center for Health Statistics (NCHS). The survey is "a complex, stratified, multistage, probability-cluster design survey" designed to collect data on the health and nutrition of a representative sample of the US population. NHANES measured the metabolite Acetyl-S-(n-propyl)-L-cysteine (BPMA) in urine spot samples in males and females ages 6+ years. In the Fourth Report on Human Exposure to Environmental Chemicals (CDC, 2019), statistics were reported for the geometric mean and for the 50th, 75th, 90th, and 95th percentiles of both uncorrected concentrations and creatinine corrected concentrations for the following 2-year cycles: 2005-2006 (n= 3,334-3,346), 2011-2012 (n=2,464-2,466), and 2013-2014 (n=2,638-2,639). The 50th and 95th percentiles for the uncorrected concentrations were 2.96 and 52.0 |ig/L in 2005-2006, 3.70 and 43.7 |ig/L in 2011-2012, and 3.70 and 43.7 |ig/L in 2013-2014. Reference for Updated Tables, 2019 Centers for Disease Control and Prevention. Fourth Report on Human Exposure to Environmental Chemicals, Updated Tables, (January 2019). Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, https://www.cdc.gov/exposurereport/ ------- |