PEER REVIEW DRAFT - DO NOT CITE OR QUOTE

EPA
United States
Environmental Protection Agency
Office of Chemical Safety
and Pollution Prevention
Draft Risk Evaluation for
1-Bromopropane
(n-Propyl Bromide)
1-BP Systematic Review Supplemental File: Data Quality
Evaluation of Ecological Hazard Studies
CASRN: 106-94-5
July, 2019, DRAFT

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Table of Contents
HERO	Data Type	Reference	1
ID
32171	Acute (0-96 hour); Aquatic; Fish	Geiger, D. L.,Call, D. J.,Bro°ke, L. T.. 1988. Acute toxicities of organic chem-	1
icals to fathead minnows (Pimephales promelas): Volume IV.

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Study Citation: Geiger, D. L.,Call, D. J.,Brooke, L. T.. 1988. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas): Volume
IV.
Data Type:	Acute (0-96 hour); Aquatic; Fish
Hero ID:	32171
Domain	Metric	Rating^ MWF* Score	Comments^
Domain 1: Test Substance
Metric 1:
Test Substance Identity
High
X
2
2
Metric 2:
Test Substance Source
High
X
1
1
Metric 3:
Test Substance Purity
High
X
1
1
Domain 2: Test Design
Metric 4: Negative Controls	Low	x 2 6
Metric 5: Negative Control Response	High x 1	1
Metric 6: Randomized Allocation	High x 1	1
Negative control was used, but the specific condi-
tions were not reported. No mortalities reported in
the negative control, so this is not expected to im-
pact the outcome of this study.
No mortalities reported in the negative control.
Study Authors reported that, "at the start of a test,
individuals were removed from the common pool of
fish with a net and distributed at random among the
exposure chambers."
Domain 3: Exposure Characterization
Metric 7: Experimental System/Test Media Prepara- Medium x 2
tion
Metric 8: Consistency of Exposure Administration	High	x	1	1
Metric 9: Measurement of Test Substance Concentra- High	x	1	1
tion
Metric 10: Exposure Duration and Frequency	High	x	2	2
Metric 11: Number of Exposure Groups/Spacing of Ex- High	x	1	1
posure Levels
The experimental system and/or test media prepara-
tion methods wereadequately reported but did not
completely account for physical-chemicalproperties
in that the volatilization was reported for the test
material. However, the identified limitations are un-
likely to have a substantial impact on results, as the
authors analytically-verified the exposure concentra-
tions during the experiment.
Flow-through system used
Gas-Liquid Chromatography used to analyze test
concentrations.
96-Hour exposure duration reported by the study
authors
Continued on next page

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. continued from previous page
Study Citation: Geiger, D. L.,Call, D. J.,Brooke, L. T.. 1988. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas): Volume
IV.
Data Type:	Acute (0-96 hour); Aquatic; Fish
Hero ID:	32171
Domain
Metric
Rating^
MWF*
Score
Comments^
Metric 12:
Testing at or Below Solubility Limit
High
X
1
1

Domain 4: Test Organism






Metric 13:
Test Organism Characteristics
High
X
2
2
Use of fathead minnows as a test species is consistent






with EPA guideline-recommended practices for con-






ducting acute toxicity testing with fish. The intro-






duction of the study report describes specific details






of the test organisms including age and life-stage as






well as a description of the species. The source of






the test organisms was described by the authors as,






"Fathead minnows used in the tests were cultured at






the U.S. EPA Environmental Research Laboratory-






Duluth and the University of Wisconsin- Superior






campus."
Metric 14:
Acclimitization and Pretreatment Conditions
High
X
1
1

Metric 15:
Number of Organisms and Replicates per
High
X
1
1


Group





Metric 16:
Adequacy of Test Conditions
High
X
1
1

Domain 5: Outcome Assessment
Metric 17: Outcome Assessment Methodology	High x 2 2
Metric 18: Consistency of Outcome Assessment	High x 1	1
Domain 6: Confounding / Variable Control
Metric 19: Confounding Variables in Test Design and High x 2 2
Procedures
Metric 20: Outcomes Unrelated to Exposure	High x 1	1
Domain 7: Data Presentation and Analysis
Metric 21: Statistical Methods	High	X 1	1 The estimated LC50 and EC50 with correspond-
ing 95 percent confidence intervals were calculated
using the corrected average of the analyzed tank
concentrations and the Trimmed Spearman-Karber
Method.
Metric 22: Reporting of Data	High x 2 2
Continued on next page . . .

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. continued from previous page
Study Citation: Geiger, D. L.,Call, D. J.,Brooke, L. T.. 1988. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas): Volume
IV.
Data Type:	Acute (0-96 hour); Aquatic; Fish
Hero ID:	32171
Domain	Metric	Rating^ MWF* Score	Comments^
Metric 23: Explanation of Unexpected Outcomes	High x 1
Overall Quality Determination"'"
High
1.2
Extracted
Yes


*	MWF = Metric Weighting Factor
t High = 1; Medium = 2; Low = 3; Unacceptable = 4; N/A has no value.
*	The overall rating is calculated as necessary. EPA may not always provide a comment for a metric that has been categorized as High.
( 4	if any metric is Unacceptable
Overall rating =
I V. (Metric Score,- x MWF,') I V ..
'3
J]. (Metric Score; x MWF;) / J] . MWFj
(round to the nearest tenth) otherwise
where High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3. If the reviewer determines that the overall rating needs adjustment, the original rating is
crossed out and an arrow points to the new rating,
ft Metrics that are rated 'High' met the criteria for high confidence as expected for this type of study, and may not require additional comments.

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