*** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Dossier for Candidate Low-Priority Substance Propanol, Oxybis- (CASRN 25265-71-8) (Dipropylene Glycol) For Release at Proposal August 9, 2019 Office of Pollution Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue Washington, DC 20460 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Contents 1. Introduction 3 2. Background on Dipropylene Glycol 5 3. Physical-Chemical Properties 6 3.1 References 8 4. Relevant Assessment History 10 5. Conditions of Use 12 6. Hazard Characterization 12 6.1 Human Health Hazard 15 6.1.1 Absorption, Distribution, Metabolism, and Excretion 16 6.1.2 Acute Toxicity 17 6.1.3 Repeated Dose Toxicity 18 6.1.4 Reproductive and Developmental Toxicity 18 6.1.5 Genotoxicity 19 6.1.6 Carcinogenicity 19 6.1.7 Neurotoxicity 19 6.1.8 Skin Sensitization 20 6.1.9 Skin Irritation 20 6.1.10 Eye Irritation 20 6.1.11 Hazards to Potentially Exposed or Susceptible Subpopulations 20 6.2 Environmental Hazard 20 6.2.1 Acute Aquatic Toxicity 21 6.2.2 Chronic Aquatic Toxicity 21 6.3 Persistence and Bioaccumulation Potential 21 6.3.1 Persistence 21 6.3.2 Bioaccumulation Potential 22 7. Exposure Characterization 12 i ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 7.1 Production Volume Information 12 7.2 Exposures to the Environment 12 7.3 Exposures to the General Population 13 7.4 Exposures to Potentially Exposed or Susceptible Subpopulations 13 7.4.1 Exposures to Workers 13 7.4.2 Exposures to Consumers 14 7.4.3 Exposures to Children 14 7.5 References 14 8. Summary of Findings 15 8.1. Hazard and Exposure Potential of the Chemical Substance 15 8.2. Persistence and Bioaccumulation 16 8.3. Potentially Exposed or Susceptible Subpopulations 16 8.4. Storage near Significant Sources of Drinking Water 17 8.5. Conditions of Use or Significant Changes in Conditions of Use of the Chemical Substance 18 8.6. The Volume or Significant Changes in Volume of the Chemical Substance Manufactured or Processed 19 8.7. Other Considerations 19 9. Proposed Designation 20 Appendix A: Conditions of Use Characterization I A.1. CDR Manufacturers and Production Volume I A.2. Uses II A.2.1 Methods for Uses Table II A.2.2 Uses of Dipropylene Glycol Ill A.3 References XXXI Appendix B: Human Hazard Characterization XXXVIII B.1 References: Llll Appendix C: Literature Search Outcomes LVIII C.1 Literature Search and Review LVIII Figure C.1: Overview of the Literature Search and Review Process LVIII C.1.1 Search for Analog Data LVIII C.1.2 Search Terms and Results LIX II ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** C.2 Excluded Studies and Rationale LXI C.2.1 Human Health Hazard Excluded References LXI C.2.2 Environmental Hazard LXVII C.2.3 Fate LXXI Appendix D: Summary of Public Comments LXXIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Tables Table 1: Dipropylene Glycol at a Glance 5 Table 2: Physical-Chemical Properties for Dipropylene Glycol 6 Table 3: Conditions of Use for Dipropylene Glycol 14 Table 4: Low-Concern Criteria for Human Health and Environmental Fate and Effects 16 Table 5: Dipropylene Glycol and Analog Structures 16 Table A.1:1986-2015 National Production Volume Data for Dipropylene Glycol (Non-Confidential ^ Production Volume in Pounds) Table A.2: Sources Searched for Uses of Dipropylene Glycol II Table A.3: Uses of Dipropylene Glycol 14 Table B.1: Human Health Hazard XLVI Table B.2: Environmental Hazard XLVIII Table B.3: Fate XLIX Table C.1: Sources Used for Analog Search LXVII Table C.2: Search Terms Used in Peer-Reviewed Databases LIX Table C.3: Search Terms Used in Grey Literature and Additional Sources LX Table C.4: Off-Topic References Excluded at Title/Abstract Screening for Human Health Hazard LXI Table C.5: Screening Questions and Off-Topic References Excluded at Full Text Screening for Human Health Hazard Table C.6: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Human Health Hazard - Animal i ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table C.7: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Human Health Hazard - In Vitro Table C.8: Off-Topic References Excluded at Title/Abstract Screening for Environmental Hazard LXVIII Table C.9: Screening Questions and Off-Topic References Excluded at Full-Text Screening for Environmental Hazard Table C.10: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Environmental Hazard Table C.11: Off-Topic References Excluded at Initial Screening for Fate LXXI Table C.12: Screening Questions and Off-Topic References Excluded at Full-Text Screening for Fate .... LXXII Table C.13: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for _ , LXXII Fate ii ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 1. Introduction In the Lautenberg amendments to the Toxic Substances Control Act (TSCA) (section 6(b)(1)(B)) and implementing regulations (40 CFR 702.3), a low-priority substance is described as a chemical substance that the Administrator concludes does not meet the statutory criteria for designation as a high-priority substance, based on information sufficient to establish that conclusion, without consideration of costs or other non-risk factors. A high-priority substance is defined as a chemical substance that the Administrator concludes, without consideration of costs or other non-risk factors, may present an unreasonable risk of injury to health or the environment because of a potential hazard and a potential route of exposure under the conditions of use, including an unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant by the Administrator. Propanol, oxybis-, referenced as dipropylene glycol for the remainder of this document, is one of the 40 chemical substances initiated for prioritization as referenced in a March 21, 2019 notice (84 FR 10491).1 Before determining low or high prioritization status, under EPA's regulations at 40 CFR 702.92 and pursuant to section 6(b)(1)(A) of the statute, EPA will generally use reasonably available information to screen the candidate chemical substance under its conditions of use against the following criteria and considerations: the hazard and exposure potential of the chemical substance; persistence and bioaccumulation; potentially exposed or susceptible subpopulations; storage near significant sources of drinking water; conditions of use or significant changes in the conditions of use of the chemical substance; the chemical substance's production volume or significant changes in production volume; and other risk-based criteria that EPA determines to be relevant to the designation of the chemical substance's priority. Designation of a low-priority substance indicates that the chemical does not meet the statutory criteria for a high-priority substance and that a risk evaluation is not warranted at the time. This risk-based, screening-level review is organized as follows: Section 1 (Introduction): This section explains the requirements of the Lautenberg amendments to the Toxic Substances Control Act (TSCA) and implementing regulations - including the criteria and considerations ~ pertinent to prioritization and designation of low- priority substances. 1 https://www.federalregister.gov/docimients/2019/03/21/2019-054Q4/initiation-of-prioritization-under-tlie-toxic-substances- control-act-tsca 2 Hie prioritization process is explained in the Procedures for Prioritization of Chemicals for Risk Evaluation Under the Toxic Substances Control Act (82 ER 33753). 3 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Section 2 (Background on the Proposed Low-Priority Substance): This section includes information on attributes of the chemical substance, including its structure, and relates them to its functionality. Section 3 (Physical-Chemical Properties): This section includes a description of the physical- chemical properties of the chemical substance and explains how these properties lead to the chemical's fate, transport, and exposure potential. Section 4 (Relevant Assessment History): This section includes an overview of the outcomes of other governing entities' assessments of the chemical substance. Section 5 (Conditions of Use): This section presents the chemical substance's known, intended, and reasonably foreseen conditions of use under TSCA. Section 6 (Hazard Characterization): This section summarizes the reasonably available hazard information and benchmarks the information against low-concern thresholds. Section 7 (Exposure Characterization): This section includes a qualitative summary of potential exposures to the chemical substance. Section 8 (Summary of Findings): In this section, EPA presents information pertinent to prioritization against each of the seven statutory and regulatory criteria and considerations, and proposes a conclusion based on that evidence. Section 9 (Proposed Designation): In this section, EPA presents the proposed designation for this chemical substance. Appendix A (Conditions of Use Characterization): This appendix contains a comprehensive list of TSCA and non-TSCA uses for the chemical substance from publicly available databases. Appendix B (Hazard Characterization): This appendix contains information on each of the studies used to support the hazard evaluation of the chemical substance. Appendix C (Literature Search Outcomes): This appendix includes literature search outcomes and rationales for studies that were identified in initial literature screening but were found to be off-topic or unacceptable for use in the screening-level review. Appendix D (Summary of Public Comments): This appendix includes sources of information for the chemical substance that the public recommended to EPA during a 90-day comment period. ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 2. Background on Dipropylene Glycol Table 1 below provides the CAS number, synonyms, and other information on dipropylene glycol. Table 1: Dipropylene Glycol at a Glance Chemical Name Dipropylene Glycol CASRN 25265-71-8 Synonyms Oxypropyl ether; 1-(1-hydroxypropoxy)propan-1-ol; Oxybispropanol; Propanol, oxybis- Trade Name(s) DPG; DPG LO+ Molecular Formula C6H14O3 Representative Structure CH, CH, £ HO^ CHj CHj e mix Source(s): Kim etal. (2016); The Dow Chemical Company (2009a; 2009b); Synapse Information Resources (n.d); NLM (2018a) Dipropylene glycol is a P-series glycol ether made from propylene oxide. Glycol ethers are organic chemical compounds that contain both an alcohol functional group (R-OH) and an ether functional group, which is an oxygen atom connected to two alkyl groups (R-O-R ). Dipropylene glycol is a mixture of isomeric chemical compounds which include combinations of the linear and branched forms of the propyl alcohol groups. Dipropylene glycol is produced as a byproduct of the manufacture of propylene glycol. Dipropylene glycol is an odorless solvent with a high boiling point and is completely soluble in water while also maintaining the ability to dissolve oils. In addition, dipropylene glycol is hygroscopic and acts as a humectant, which means it absorbs water and increases hydration in products. Dipropylene glycol also functions as a plasticizer and as a plasticizer intermediate in the formation of polyurethane polyols to improve flexibility and increase resistance to cracking at low temperatures. A plasticizer is a substance that is added to a material to alter its physical properties, mainly to increase flexibility or decrease viscosity. These properties make dipropylene glycol a multifunctional ingredient used in a variety of applications and product sectors. Section 5 includes conditions of use for this chemical. 5 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 3. Physical-Chemical Properties Table 2 lists physical-chemical properties for dipropylene glycol. A chemical's physical-chemical properties provide a basis for understanding a chemical's behavior, including in the environment and in living organisms. These endpoints provide information generally needed to assess potential environmental release, exposure, and partitioning as well as insight into the potential for adverse toxicological effects. Table 2: Physical-Chemical Properties for Dipropylene Glycol Source/Model Data Type Endpoint Endpoint value Notes Sigma Aldrich 2019; SIDS 2001 Experimental Physical state at room temp (based on melting point) Liquid (-20°C at 101.3 hPa (76 mmHg)) Liquid (-39 °C) Commercial mixture of CASRN 108-61-2; 110-98-5 and 106-62-7 ECHA 2019; HSDB, 2016; Kirk-Othmer, 2006 Experimental Molecular Weight 134 g/mol EPISuite v.4.113 Calculated Molecular Weight 134.18 g/mol EPISuite was run for two isomers. The only difference in the predicted values is in the atmospheric oxidation model. Lyman 1990 Experimental Molar Volume 166 cm3/mol ECHA 2019 Experimental Water Solubility 1000000 mg/L (100% vol) at 20 "CandpH 7.4 Value measured according to EU Method A.6, flask method. HSDB 2016; SIDS 2001 Experimental Water Solubility 1000000 mg/L (miscible) EPISuite v.4.11 Estimated Water Solubility 6.96x105 mg/L ECHA 2019; HSDB 2016 Experimental Water Solubility 7.45 mol/L ECHA 2019 Experimental Log P -0.462 at 21.7°C andpH6 Value measured according to EU Method A.8, shake flask. HSDB 2016 Experimental Log Kow -1.07 SIDS 2001 Experimental Log Kow -1.486; -0.687 EPISuite v.4.11 Estimated Log Kow -0.64 EPISuite v.4.11 Estimated Log Koa 6.37 EPISuite v.4.11 Estimated Log Koc 0 (MCI); -0.24 (Kow) ECHA 2019 Experimental Vapor Pressure 0.00975 mm Hg (1.3 Pa) at 25°C Value measured according to EU Method A.4 HSDB 2016 Experimental Vapor Pressure 0.0319 mm Hgat25°C 3 epi Suite Physical Property inputs - Boiling Point = 230.5 deg C, MP = 0 deg C, Vapor Pressure = 0.0319 mm Hg, Water Solubility = 1000000 mg/L, Log P = -0.46, SMILES: OC(C)COC(C)CO 6 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table 2: Physical-Chemical Properties for Dipropylene Glycol Source/Model Data Type Endpoint Endpoint value Notes Kirk-Othmer 2006 Experimental Vapor Pressure 0.016 mm Hg (0.0021 kPa) at 25°C ChemID 2019 Experimental Vapor Pressure 0.0319 mm Hg at25°C SIDS 2001 Experimental Vapor Pressure < 0.075 mm Hg (0.01 hPa) at 20 °C;< 0.01 torr (0.013 hPa) at 20 °C; 0.04 torr (0.05 hPa) at 21 °C Chadwick 1988 Experimental Vapor Pressure <0.0075 mm Hg (0.001 kPa) at 20 °C EPISuite v.4.11 Estimated Vapor Pressure 7.30x10-3 mm Hg ECHA 2019 Experimental Vapor Pressure 34.6x10"12 cm3/molecule-sec SIDS 2001 Experimental Vapor Pressure 3.72 (half-life, hours) EPISuite v.4.11 Estimated Henry's Law <1E-8 atm-m3/mol EPISuite v.4.11 Estimated Volatilization 5000 days (river) 55000 days (lake) EPISuite v.4.11 Estimated Photolysis (Indirect) 4.1 hours (T1/2) EPISuite v.4.11 Estimated Photolysis (Indirect) 3.72 hours OH rate constant 3.46 E-11 cm3/molecule-second (12 hour day; 1.5E6 OH/cm3) No ozone reaction EPISuite v.4.11 Estimated Hydrolysis Rate constants cannot be estimated No hydrolyzable functional groups EPISuite v.4.11 Estimated Biodegradation potential Ready prediction: Yes EPISuite v.4.11 Estimated BAF 0.9 EPISuite v.4.11 Estimated BCF 3.16 Based on regression equation 7 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Based on its reported physical form and measured melting point, dipropylene glycol is a liquid under ambient conditions (Sigma Aldrich, 2019). Exposure through direct dermal contact with the substance is possible, but concern is lessened because this chemical is a slow skin penetrant (discussed in Section 6.1.1) and likely to be minimally absorbed through skin based on its molecular weight, water solubility and log Kow. Because of its measured vapor pressure (ECHA, 2019), dipropylene glycol is expected to be volatile when present in neat form or as an undiluted substance at ambient temperatures. As a result, exposure to dipropylene glycol is possible through inhalation of vapors or aerosols if they are generated. Based on measured solubility data (OECD SIDS, 2001), dipropylene glycol is considered water soluble, indicating the potential for this substance to dissolve in water and form an aqueous solution. Water soluble substances have an increased potential for absorption through the lungs; therefore, if inhalation of vapors or aerosols occurs, absorption through the lungs is likely. Exposure potential changes if dipropylene glycol is present in diluted form. The estimated Henry's Law constant for dipropylene glycol (EPI Suite, 2019) indicates volatilization from water and aqueous solutions would be minimal; therefore, exposure through breathing vapor from a dilute form is expected to be minimal. Absorption and sequestration in fatty tissues are unlikely, as reflected in the estimated BAF and BCF values for this compound (EPI Suite, 2019). The estimated log Koc (EPI Suite, 2019) indicates this substance is highly mobile in soils, increasing its potential for leaching into groundwater, including ground water sources of drinking water. If oral exposure occurs via ingestion of contaminated drinking water, including well water, absorption through the gastrointestinal tract is likely based on experimental evidence (discussed in Section 6.1.1). Concern for presence in drinking water is reduced in part by dipropylene glycol's expected low persistence (discussed in Section 6.3.1) and low-hazard findings from toxicological studies of organisms exposed to dipropylene glycol in drinking water (discussed in Section 6.1). Experimental data indicate it is readily biodegradable in aerobic environments, meaning that it has the potential to break down in the environment into carbon dioxide and water (ECHA, 2007, 4940427). 3.1 References Chadwick, Sharon S. (1988). "Ullmann's Encyclopedia of Industrial Chemistry", Reference Services Review, Vol. 16 Issue: 4, pp.31-34, https://doi.org/10.1.108/eb049034 ChemlDplus. (2019). Dipropylene Glycol. Retrieved from https://chem.nlm.nih.gov/chemidplus/rn/25265-71-8 European Chemicals Agency (ECHA). (2019). Oxydipropanol: biodegradation in water: screening tests: 001 key | experimental result. Retrieved from https://lieronet.epa.gov/lieronet/index.cfin/reference/download/reference id/4940427 European Chemicals Agency (ECHA). (2019). Oxydipropanol. Retrieved from https://echa.europa.eu/registration-dossier/-/registered-dossier/14788 Hazardous Substance Database (HSDB). (2016). Dipropylene glycol. Retrieved from https://toxnet.nlm.nih.gov/ Kirk-Othmer. (2006). Kirk-Othmer Encyclopedia of Chemical Technology. 8 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Lyman, Warren J., Reehl, W. F., Rosenblatt, D. H. (1990). Handbook of chemical property estimation methods: environmental behavior of organic compounds. American Chemical Society OECD SIDS (2001). Dipropylene glycol (mixed isomers and dominant isomer Cas No: 25265-71-8 and 110-98-5 https://heronet.epa.gov/heronet/index.cfm/reference/download/reference_id/4940388 Sigma Aldrich (2019). Tripropylene glycol. Retrieved from https://www.sigmaaldrich.com/catalog/product/aldrich/d215554?lang=en®ion=US U.S. EPA. (2019). Estimation Programs Interface Suite, v 4.11. United States Environmental Protection Agency, Washington, DC, USA 9 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 4. Relevant Assessment History EPA assessed the toxicological profile of dipropylene glycol and added the chemical to the Safer Choice Program's Safer Chemical Ingredients List (SCIL) in September 2012 under the functional class of solvents. The SCIL4 is a continuously updated list of chemicals that meet low-concern Safer Choice criteria.5 To better understand the hazard and exposure profile of certain chemical substances, EPA promulgated the Preliminary Assessment Information Rule (PAIR) under TSCA in June 1992 to require manufacturers and importers to submit a standardized reporting form for each site at which they were manufacturing or importing a listed chemical substance to collect general volume, end use, and exposure-related information. The chemical substances chosen for PAIR were those with possibly high exposure potential or for which information about toxicity had been previously obtained. In January 1994, EPA added dipropylene glycol to PAIR because of regulatory interest to the Occupational Safety and Health Administration (OSHA) given the chemical's lack of dermal absorption test data. Inclusion of dipropylene glycol in the PAIR rule is not indicative of current EPA concern about this chemical because of data that is now available on dermal absorption (see Section 6.1.1), and EPA's high confidence in the chemical's low-hazard profile. EPA also reviewed international assessments of dipropylene glycol. EPA identified assessments by the Organisation for Economic Co-operation and Development (OECD), and government agencies in Canada, Australia, Germany, New Zealand, and Japan. The OECD Screening Information Datasets (SIDS) Initial Assessment Meeting (SIAM) discussed the SIDS Initial Assessment Report (SIAR) on dipropylene glycol (mixed isomers and dominant isomer), in January 2001. The SIAM determined this chemical to be "low priority for further work" for human health and the environment.6 The Canadian Government, through an assessment of toxicity and exposure as part of its categorization of the Domestic Substance List, found that dipropylene glycol did not meet its criteria for further attention.7 The Australian Government's Department of Health National Industrial Chemicals Notification and Assessment Scheme (NICNAS) determined dipropylene glycol to not pose an unreasonable risk to the health of workers and public health on the basis of the Tier I Inventory Multi-tiered Assessment and Prioritisation (IMAP) assessment.8 4 https://www.epa.gov/saferchoice/safer-iiigredients 5 https://www.epa.gov/sites/prodiiction/files/2013-12/dociiiiieiits/dfe master criteria safer ingredients v2 l.pdf 0 Iittps://hpvcliemicals.oecd.org/iii/handler.axd?id=40da06bl-a855-4c0c-bc21-bbc856dca725 7 https://canadachemicals.oecd. org/CliemicalDetails.aspx?ChemicalID=1044BC0C-01F2-4BC4-99B3-DEFF37D7B966 8 https://www.nicnas.gov.aii/cheniical-inforniation/iniap-assessnients/iniap-assessnients/liiinian-healtli-assessnients 10 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** The German Environment Agency (UBA) designated dipropylene glycol as "low hazard to waters" in August 2017 based on an assessment of ecotoxicity and environmental fate.9 New Zealand's Environmental Protection Authority lists dipropylene glycol in its Chemical Classification and Information Database (CCID), which includes hazard and physical information about single chemicals for use in hazard classifications and safety information. It has a classification description as "mildly irritating to the skin" and "irritating to the eye."10 Sections 6.1.9 and 6.1.10 of this screening review contain a summary of the reasonably available information on these endpoints and an explanation of why EPA does not believe irritation is a concern for this chemical. Japan's National Institute of Technology and Evaluation (NITE) categorized dipropylene glycol as hazard class 4 for ecological effect in 2017, which is the lowest concern hazard ranking assigned.11 9 https://webrigoletto.ute.de/rigoletto/public/searcliDetail.do7keiiiiuiiiiiieF341.9 -search/chemical-classification-and-information-database-ccid/view/2785 ' https://www.nite.go.ip/chem/icheck/detail.action?cno=25265-71-8&miio=2-0413&requesttocale=eii 11 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 5. Conditions of Use Per TSCA section 3(4), the term "conditions of use" means the circumstances, as determined by the Administrator, under which a chemical substance is intended, known, or reasonably foreseen to be manufactured, processed, distributed in commerce, used, or disposed of. EPA assembled information on all uses of dipropylene glycol (Appendix A) to inform which uses would be determined conditions of use.12 One source of information that EPA used to help determine conditions of use is 2016 Chemical Data Reporting (CDR). The CDR rule (previously known as the Inventory Update Rule, or IUR), under TSCA section 8, requires manufacturers (including importers) to report information on the chemical substances they produce domestically or import into the U.S., generally above a reporting threshold of 25,000 lb. per site per year. CDR includes information on the manufacturing, processing, and use of chemical substances with information dating to the mid-1980s. CDR may not provide information on other life-cycle phases such as the chemical substance's end-of-life after use in products (i.e., disposal). According to CDR, dipropylene glycol is manufactured domestically and imported. It is used in processing (incorporation into formulation, mixture or reaction and incorporation into article for textiles, apparel, leather manufacturing, lubricants and lubricant additives, cleaning compounds, toilet preparation manufacturing, and other applications); it is also used as a reactant in plastic material and resin manufacturing; and for repackaging lubricant and lubricant additives, among other applications. Examples of industrial uses include oil and gas drilling, extraction and support activities, and construction and building materials covering large surface areas. Consumer and commercial uses include cleaning and furnishing care products; ink, toner, and colorant products; laundry and dishwashing products; paints and coatings, air care products; and finger paints and toys, among others. Based on the known manufacturing, processing, and uses of this chemical substance, EPA assumes distribution in commerce. According to CDR, dipropylene glycol was reported as recycled by at least one site. No information on disposal is found in CDR or through EPA's Toxics Release Inventory (TRI) Program13 because dipropylene glycol is not a TRI-reportable chemical. Although reasonably available information did not specify additional types of disposal, for purposes of this proposed prioritization designation, EPA assumed end-of-life pathways that include releases to air, wastewater, surface water, and land via solid and liquid waste based on the conditions of use (e.g., incineration, landfill). To supplement CDR, EPA conducted research through the publicly available databases listed in Appendix A (Table A.2) and performed additional internet searches to clarify conditions of use or find additional occupational14 and consumer uses. This research improved the Agency's understanding of the conditions of use for dipropylene glycol. Although EPA identified uses of dipropylene glycol in personal care products, this screening review covers TSCA conditions of use for the chemical substance and personal care products are not considered in EPA's assessment. Exclusions to TSCA's regulatory scope regarding "chemical substance" can be found at TSCA 12 Hie prioritization process, including the definition of conditions of me, is explained in the Procedures for Prioritization of Chemicals for Risk Evaluation Under the Toxic Substances Control Act (82 ER 33753). 13 https://www.epa.gov/toxics-release-inventorv-tri-program 14 Occupational uses include industrial and/or commercial uses 12 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** section 3(2). Table 3 lists the conditions of use for dipropylene glycol considered for chemical substance prioritization, per TSCA section 3(4). Table 3 reflects the TSCA uses determined as conditions of use listed in Table A.3 (Appendix A). 13 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table 3: Conditions of Use for Dipropylene Glycol Life Cycle Stage Category Subcategory of Use Source Manufacturing Domestic manufacture Domestic manufacture EPA (2017b) Import Import Processing Processing- incorporation into Finishing agents - textiles, apparel, and leather manufacturing EPA (2017b), Sherlock (2019) formulation, mixture or reaction Lubricants and lubricant additives - all other chemical product and preparation manufacturing Pigments and dyes-paper manufacturing Solvents (which become part of product formulation or mixture)- soap, cleaning compound, and toilet preparation manufacturing; All other basic organic chemical manufacturing; Paint and coating manufacturing; Plastics product manufacturing; Printing ink manufacturing; Rubber product manufacturing; Odor agents- soap, cleaning compound, and toilet preparation manufacturing Finishing agents-textiles, apparel, and leather manufacturing Agricultural chemicals (non-pesticidal)- agriculture, forestry, fishing and hunting Process regulators- petrochemical manufacturing, petroleum refineries Functional fluids (closed systems)- transportation equipment manufacturing Intermediates- all other basic organic chemical manufacturing Finishing agents- textiles, apparel, and leather manufacturing Processingincorporation into article Surface active agents- soap, cleaning compound, and toilet preparation manufacturing Intermediates- plastic material and resin manufacturing; All other basic organic chemical manufacturing; Petrochemical manufacturing; Plastic material and resin manufacturing Processing as a reactant Catalyst- construction Paint additives and coating additives not described by other categories- paint and coating manufacturing Accelerator- plastic material and resin manufacturing Processing aids, not otherwise listed- carbon black manufacturing Processing - repackaging Lubricants and lubricant additives- lubricants and lubricant additives 14 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Industrial manufacturing Automotive manufacturing; basic metal manufacturing; building material manufacturing; communication equipment manufacturing; computer and electronic manufacturing; fabricated metal products manufacturing; food manufacturing; furniture manufacturing; iron metal manufacturing; leather product manufacturing; metals manufacturing; non-metallic mineral product manufacturing; perfume manufacturing; soap manufacturing; windmill manufacturing; wood manufacturing CPCat (2019); ECHA (2018b) Pesticide, fertilizer, and other agricultural chemical manufacturing Crop and animal production; fertilizers Recycling Recycling EPA (2017b)15 Distribution Distribution Distribution EPA (2017b) Industrial Usenon-incorporative activities Surface active agents- wholesale and retail trade EPA (2017b) Other Mining; test drilling and boring; coloring agents; printing; sewage treatment; CPCat (2019); ECHA (2018b) Oil and gas drilling, extraction, and support activities Motor vehicle maintenance and repair; oil and gas exploration/production; automotive fuel; crude petroleum and natural gas extraction; tracking, fuel additive Construction and building materials covering large surface areas Brick-layering; building construction; building glass; demolition; plumbing installation; floor and wall covering; ship building Industrial/ commercial/ consumer Water treatments including softeners and lime deposit removers CPCat (2019); ECHA (2018b) Industrial/ commercial Industrial cleaning Paints and coatings CPCat (2019) 15 According to CDR reports, at least one manufacturer indicates that the chemical substance is recycled onsite. No other information is available to indicate that other recycling is taking place. Reasonably available information did not specify types of disposal, but EPA assumes these releases based on the conditions of use. 15 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Commercial/ consumer Cleaning and furnishing care products; laundry and dishwashing products; Bathroom cleaner, boat cleaner; carpet and upholstery cleaner; drain cleaner; floor cleaner; floor polish; furniture polish; general purpose cleaner; glass cleaner; granite cleaner and polish, hard surface cleaner; kitchen cleaner; oven/grill cleaner; shower cleaner; stain remover; toilet bowl cleaner; dishwasher cleaner; dishwasher detergent; fabric freshener; fabric softener; laundry detergent; laundry detergent scent additive; prewash stain remover EPA (2017b); ECHA (2018b); DeLima Associates (2013c); CPCat (2019), DeLima Associates (2015f); DeLima Associates (2014c); DeLima Associates (2015m); GoodGuide (2011a); DeLima Associates (2015o); DeLima Associates (2015j); DeLima Associates (2015d); DeLima Associates (2015k); DeLima Associates (2017a); DeLima Associates (2015c); DeLima Associates (2015b); DeLima Associates (2015h); DeLima Associates (2015e); DeLima Associates (2015i); DeLima Associates (2016b); DeLima Associates (2014e); Synapse Information Resources (n.d.) Paints and coatings Paint and varnish remover; polishing agents Automotive care Car wax CPCat (2019) Anti-free and de-icing products Lubricants and greases Hydraulic fluids ECHA (2018b) Ink, toner, and colorant products Ink and toner CPCat (2019); Synapse Information Resources (n.d.); ECHA (2018b) Adhesives and sealants Non-structural caulking compounds and sealants; adhesives GoodGuide (2011a) Other Degreasers; rust remover; pet litter; photographic CPCat (2019); ECHA 2018b) Commercial Agricultural products (non-pesticidal) EPA (2017b); CPCat (2019); Other Catalysts Dow (2009b); Sherlock (2019) Dry cleaning Building/construction materials not covered elsewhere Golf and sports turf 18 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Lubricants and greases Paper products; plastic and rubber products not covered elsewhere; Urethane intermediate Cleaning and furnishing care products Other Descaling agent ECHA (2018b) Consumer Air care products Air freshener; candle DeLima Associates (2013a); GoodGuide (2011a); CPCat (2019); ECHA (2018b); DeLima Associates (2015g) Absorbents/adsorbents; casting and molding; welding and soldering; whiteboard marker DeLima Associates (2013b); GoodGuide (2011a); CPCat (2019); Descartes Datamyne (2018), ECHA (2018b) Toys, playground, and sporting equipment Finger paints; toys ECHA (2018b); CPCat (2019) Unknown Food and beverage service activities; anti-foaming agent CPCat (2019) Disposal Releases to air, wastewater, solid and liquid wastes EPA's assumptions based on the identified uses16 16 See Section 5 for a discussion on why releases are assumed to be reasonably foreseen for purposes of this proposed prioritization designation. 17 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 6. Hazard Characterization EPA reviewed primary literature and other data sources to identify reasonably available information on hazard for dipropylene glycol. This literature review approach17 is tailored to capture the reasonably available information associated with low-hazard chemicals. EPA also used this process to verify the reasonably available information for reliability, completeness, and consistency. EPA reviewed the reasonably available information to identify relevant, quality studies to evaluate the hazard potential for dipropylene glycol against the endpoints listed below. EPA's New Chemicals Program has used these endpoints for decades to evaluate chemical substances under TSCA18 and EPA toxicologists rely on these endpoints as key indicators of potential human health and environmental effects. These endpoints also align with internationally accepted hazard characterization criteria, such as the Globally Harmonized System of Classification and Labelling of Chemicals19 as noted above in Section 4 and form the basis of the comparative hazard assessment of chemicals. Human health endpoints evaluated: Acute mammalian toxicity, repeated dose toxicity, carcinogenicity, mutagenicity/genotoxicity, reproductive and developmental toxicity, neurotoxicity, skin sensitization, and eye and skin irritation. Environmental fate and effects endpoints evaluated: Aquatic toxicity, environmental persistence, and bioaccumulation. The low-concern criteria used to evaluate both human health and environmental fate and effects are included in Table 4 below. Table 4: Low-Concern Criteria for Human Health and Environmental Fate and Effects Human Health Acute Mammalian Toxicity20 Very High High Moderate Low Oral LD50 (mg/kg) <50 >50 - 300 > 300 - 2000 > 2000 Dermal LD50 (mg/kg) <200 >200- 1000 > 1000- 2000 > 2000 Inhalation LC50 (vapor/gas) (mg/L) <2 >2-10 >10-20 >20 Inhalation LC50 (dust/mist/fume) (mg/L) <0.5 >0.5-1.0 >1.0-5 >5 17Discussed in the document "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA." 18 https://www.epa. gov/sustainable-futures/sustainable-futures-p2-framework-manual 19 https://www.unece.org/fileadmiri/DAM/trans/danger/publi/ghs/ghs rev07/English/ST SG AC10 30 Rev7e.pdf 20 Values derived from GHS criteria (Chapter 3.1: Acute Toxicity'. 2009, United Nations). 12 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table 4: Low-Concern Criteria for Human Health and Environmental Fate and Effects Repeated Dose Toxicity (90-day study)21 High Moderate Low Oral (mg/kg-bw/day) <10 10-100 > 100 Dermal (mg/kg- bw/day) <20 20 - 200 >200 Inhalation (vapor/gas) (mg/L/6h/day) <0.2 0.2-1.0 > 1.0 Inhalation (dust/mist/fume) (mg/L/6h/day) <0.02 0.02-0.2 >0.2 Reproductive Toxicity22 High Moderate Low Oral (mg/kg/day) <50 50 - 250 >250 Dermal (mg/kg/day) <100 100-500 >500 Inhalation (vapor, gas, mg/L/day) < 1 1-2.5 >2.5 Inhalation (dust/mist/fume, mg/L/day) <0.1 0.1-0.5 >0.5 Developmental Toxicity22 High Moderate Low Oral (mg/kg/day) <50 50 - 250 >250 Dermal (mg/kg/day) <100 100-500 >500 Inhalation (vapor, gas, mg/L/day) < 1 1-2.5 >2.5 Inhalation (dust/mist/fume, mg/L/day) <0.1 0.1-0.5 >0.5 Mutagenicity/ Genotoxicity23 Very High High Moderate Low Germ cell mutagenicity GHS Category 1A or 1B: Substances known to induce heritable mutations or to be regarded as if they induce heritable mutations in the germ cells of humans. GHS Category 2: Substances which cause concern for humans owing to the possibility that they may induce heritable mutations in the germ cells of humans. Evidence of mutagenicity support by positive results in vitro OR in vivo somatic cells of humans or animals Negative for chromosomal aberrations and gene mutations, or no structural alerts. 21 Values from GHS criteria for Specific Target Organ Toxicity Repeated Exposure (Chapter 3.9: Specific Target Organ Toxicity' Repeated Exposure. 2009, United Nations). 22 Values derived from the U.S. EPA's Office of Pollution Prevention & Toxics criteria for HPV chemical categorizations (Methodology> for Risk-Based Prioritization Under ChM tP), and the EU REACH criteria for Annex IV (2007). 23 From GHS criteria (Chapter 3.5: Germ Cells Mutagenicity. 2009, United Nations) and supplemented with considerations for mutagenicity and genotoxicity in cells other than germs cells. 13 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table 4: Low-Concern Criteria for Human Health and Environmental Fate and Effects Mutagenicity and genotoxicity in somatic cells OR Evidence of mutagenicity supported by positive results in in vitro AND in vivo somatic cells and/or germ cells of humans or animals. Carcinogenicity24 Very High High Moderate Low Known or presumed human carcinogen (GHS Category 1A and 1B) Suspected human carcinogen (GHS Category 2) Limited or marginal evidence of carcinogenicity in animals (and inadequate25 evidence in humans) Negative studies or robust mechanism- based structure activity relationship (SAR) Neurotoxicity (90-day study)21 High Moderate Low Oral (mg/kg-bw/day) <10 10-100 > 100 Dermal (mg/kg- bw/day) <20 20 - 200 >200 Inhalation (vapor/gas) (mg/L/6h/day) <0.2 CD CM CD > 1.0 Inhalation (dust/mist/fume) (mg/L/6h/day) <0.02 0.02-0.2 >0.2 Sensitization26 High Moderate Low Skin sensitization High frequency of sensitization in humans and/or high potency in animals (GHS Category 1A) Low to moderate frequency of sensitization in human and/or low to moderate potency in animals (GHS Category 1B) Adequate data available and not GHS Category 1Aor 1B Respiratory sensitization Occurrence in humans or evidence of sensitization in humans based on animal or other tests (equivalent to GHS Category 1A or 1B) Limited evidence including the presence of structural alerts Adequate data available indicating lack of respiratory sensitization 24 Criteria mirror classification approach used by the IARC (Preamble to the L4RC Monographs: B. Scientific Review and Evaluation: 6. Evaluation and rationale. 2019J and incorporate GHS classification scheme (Chapter 3.6: Carcinogenicity. 2009, United Nations). 25 EPA's approach to determining the adequacy of information is discussed in the document "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA", also released at proposal. 20 From GHS criteria (Chapter 3.4: Respiratory or Skin Sensitization. 2009, United Nations). 14 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table 4: Low-Concern Criteria for Human Health and Environmental Fate and Effects Irritation/ Corrosivity27 Very High High Moderate Low Eye irritation/ corrosivity Irritation persists for >21 days or corrosive Clearing in 8-21 days, severely irritating Clearing in 7 days or less, moderately irritating Clearing in less than 24 hours, mildly irritating Skin irritation/ corrosivity Corrosive Severe irritation at 72 hours Moderate irritation at 72 hours Mild or slight irritation at 72 hours Environmental Fate and Effects Acute Aquatic Toxicity Value (L/E/ICso)28 Chronic Aquatic Toxicity Value (L/E/IC50)28 Persistence (Measured in terms of level of biodegradation)29 Bioaccumulation Potential30 May be low concern if <10 ppm... ...and <1 ppm... ...and the chemical meets the 10-day window as measured in a ready biodegradation test... Low concern if >10 ppm and <100 ppm... ...and >1 ppm and <10 ppm... ...and the chemical reaches the pass level within 28 days as measured in a ready biodegradation test ...and BCF/BAF < 1000. Low concern if >100 ppm... ...and > 10 ppm... ... and the chemical has a half-life < 60 days... 6.1 Human Health Hazard Below is a summary of the reasonably available information that EPA included in the hazard evaluation of dipropylene glycol. In many cases, EPA used analogous chemicals to make findings for a given endpoint. Where this is the case, use of the analog is explained. If the chemical studied is not named, the study is for dipropylene glycol. Appendix B contains more information on each study. Dipropylene glycol is a mixture of dipropylene glycol isomers formed by the condensation of two propylene oxide (methyl oxirane) units. The positions of the methyl substituents are unspecified. Both analogs used to inform EPA's understanding of this chemical are oligomeric propylene glycols like dipropylene glycol. The first analog, l,r-dimethyldiethylene glycol, is a specific isomer of dipropylene glycol and is a component of dipropylene glycol. The second analog, tripropylene glycol, is similar to dipropylene glycol, and has an additional propylene oxide unit. As shown in Table 5, EPA used best professional judgement to select analogs for dipropylene glycol, based on similarity in structure, physical-chemical properties, and functionality, with the assumption that these substances will have similar environmental transport and persistence characteristics, and bioavailability and 27 Criteria derived from the Office of Pesticide Programs Acute Toxicity Categories (U.S. EPA. Label Review Manual. 2010). 28 Derived from GHS criteria (Chapter 4.1: Hazards to the Aquatic Environment. 2009, United Nations), EPA OPPT New Chemicals Program (Pollution Prevention (P2) Framework, 2005) and OPPT's criteria for HPV chemical categorization (Methodology> for Risk Based Prioritization Under C1l4MP. 2009). 29 Derived from OPPT's New Chemicals Program and DIE Master Criteria and reflects OPPT policy on PBTs (Design for the Environment Program Master Criteria for Safer Chemicals, 2010). 30 Derived from OPPT's New Chemicals Program and Arnot & Gobas (2006) [Arnote, J,A. and F,A. Gobas, A review of bioconcentration factor (BCF) and bioaccimndation factor (B*4F) assessments for organic chemicals in aquatic organisms. Environmental Reviews, 2006. 14: p. 257-297.] 15 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** toxicity profiles. Differences in the methyl group positions in these chemicals are not expected to significantly affect their chemical and hazard profiles. Table 5: Dipropylene Glycol and Analog Structures CASRN Name Structure 25265-71-8 Dipropylene glycol (mixed isomers) CHi CHi HO JL JL OH O i ClHj CHj c mix Representative structure 110-98-5 1,1 '-Dimethyldiethylene glycol ch3 ch3 Representative structure 24800-44-0 Tripropylene glycol (mixed isomers) CHa CHa CHj 6.1.1 Absorption, Distribution, Metabolism, and Excretion Absorption To assess absorption, EPA relied on experimental studies on dipropylene glycol and tripropylene glycol. In a dog study, dipropylene glycol was rapidly absorbed from the gastrointestinal tract and was no longer detectable in blood 24 hours after an oral exposure (BUA. 1996). These data indicate dipropylene glycol is rapidly absorbed after oral exposures. In vitro studies were used to assess the potential for dermal absorption by dipropylene glycol. Excised abdominal skin from human cadavers demonstrated dipropylene glycol is a slow penetrant, with the results indicating a permeability coefficient of 3.85 x 10"5 cm/hour (Fasano et al.. 2011; ECHA. 2007b; Fasano. 2007). 16 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Based on its low molecular weight and high water solubility (discussed in Section 3), dipropylene glycol is expected to be absorbed from the lungs if inhaled. Distribution Dipropylene glycol is considered water soluble based on its physical-chemical properties (Section 3) and is likely to be distributed mainly in aqueous compartments in an organism. This prediction is supported by experimental evidence on the analog tripropylene glycol. Rats exposed to tripropylene glycol by oral gavage displayed radiolabeled tripropylene glycol in the tissues and the carcass 24 hours following exposure. Specifically, tripropylene glycol was reported in the liver at 0.20%, kidneys at 0.09%, carcass at 0.06%, blood at 0.03%, and skin, brain, muscle, and fat at less than 0.03% (as percent of the administered dose per gram of tissue) (OECD., 2001; ECHA. 1995a). These data indicate tissue distribution of tripropylene glycol was rapid, especially to the liver and kidney after dosing and provide evidence that dipropylene glycol will be rapidly distributed following oral absorption. Metabolism To assess the metabolism of dipropylene glycol, EPA relied on experimental evidence from tripropylene glycol. Oral administration of tripropylene glycol to rats resulted in rapid metabolism to dipropylene glycol, then to propylene glycol, which is converted to lactic and pyruvic acids or excreted in the urine. Lactate and pyruvate may be further metabolized through the citric acid cycle to yield carbon dioxide and water or may be stored as glycogen (OECD. 2001; EG >5a). Rats exposed to 14C-tripropylene glycol by oral gavage excreted approximately 13% as free or conjugated tripropylene glycol, approximately 8.4% as free and conjugated dipropylene glycol, and approximately 3.9% as free and conjugated propylene glycol (OECD. 2001; EC] >5a). These data indicate that dipropylene glycol will be metabolized. Excretion To assess excretion, EPA relied on experimental evidence from tripropylene glycol. Following the oral administration of tripropylene glycol to rats, 52% was recovered in urine, 21% in exhaled CO 2, and 5% in the feces after 24 hours ( P., 200.1.; ECHA. 1995a). These data indicate that dipropylene glycol will be excreted from the body following exposure. 6.1.2 Acute Toxicity EPA assessed the mammalian toxicity potential for acute exposure from dipropylene glycol using results from oral, inhalation, and dermal studies. Rats exposed to dipropylene glycol by oral gavage demonstrated no mortality at the single dose tested (5010 mg/kg), resulting in an LD50 greater than 5010 mg/kg in rats (ECHA. 1995dD. Another study in rats exposed by oral gavage reported a LD50 of 15,800 mg/kg (OECD. 2001; EC £0). These results indicate low concern for acute toxicity with expected LD50S above the low-concern threshold of 2000 mg/kg for oral exposures. A study on rabbits exposed to dipropylene glycol dermally reported no adverse effects at the single dose tested (5010 mg/kg), resulting in an LD50 greater than 5010 mg/kg ("ECHA. 1995b). These 17 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** results indicate low concern for acute toxicity with expected LD50S above the low-concern threshold of 2000 mg/kg for dermal exposures. A study on rats exposed to a dipropylene glycol aerosol reported no adverse effects at the single dose tested, 2.34 mg/L (ECHA. 1995 c). Given that the single dose of the inhalation study indicated no adverse effects at a dose below the low concern threshold of 5 mg/L for aerosols, EPA incorporated experimental evidence on tripropylene glycol to inform a weight of the scientific evidence decision. A study on rats exposed to a single concentration (0.083 mg/L) of tripropylene glycol in saturated vapor for eight hours and then observed for two weeks reported no mortalities ("EC ). Based on tripropylene glycol's vapor pressure of 0.00195 torr, the expected saturation concentration is around 0.02 mg/L at room temperature, which is below the study concentration of 0.083 mg/L, which indicates the no effect concentration is occurring above complete saturation. Based on the chemical's physical-chemical properties and available experimental data, this chemical poses low concern for acute toxicity from inhalation exposures based on no adverse effects reported above the expected air saturation concentration for tripropylene glycol and no effects observed at the highest dose of the dipropylene glycol aerosol study. 6.1.3 Repeated Dose Toxicity EPA assessed the potential for mammalian toxicity from repeated exposures to dipropylene glycol using studies in mice and rats. Mice exposed to dipropylene glycol in drinking water for 13 weeks demonstrated a no observed adverse effect level (NOAEL) of 2620 mg/kg-day and a lowest observed adverse effect level (LOAEL) of 4790 mg/kg-day based on increased liver weight (ECHA. 2004g; NTP. 2004). Rats exposed to dipropylene glycol in drinking water for 14 weeks demonstrated a NOAEL of 435 mg/kg-day and a LOAEL of 890 mg/kg-day based on relative liver weight ("ECHA. 2Q04f; NTP. 2004). EPA also assessed the potential for toxicity from chronic exposures. A two-year study on mice exposed to dipropylene glycol in drinking water demonstrated a NOAEL of 1040 mg/kg-day and a LOAEL of 1950 mg/kg-day based on decreased mean body weight (ECHA. 2004e: NTP. 2004). Rats exposed to dipropylene glycol for two years in drinking water demonstrated a NOAEL of 115 mg/kg-day and a LOAEL of 470 mg/kg-day based on incidence of nephropathy, focal histiocytic and focal granulomatous inflammation in male livers (ECHA. 2004b. d; NTP. 2004). These results indicate low concern for toxicity resulting from repeated exposures by exceeding the low-concern threshold of 100 mg/kg-day for a 90-day study. 6.1.4 Reproductive and Developmental Toxicity EPA assessed the potential for reproductive toxicity using read-across from an analog, tripropylene glycol. In a combined repeated dose, reproductive, and developmental study, rats were exposed to tripropylene glycol via oral gavage for 49 days, beginning 14 days prior to mating and through lactation day 3 for females. The authors reported no reproductive (mating, fertility, and estrus cycle) or developmental effects (external examinations of the pups and pup body weight gain) at the highest dose tested (1000 mg/kg-day). The NOAEL for this study was 1000 mg/kg-day (OECD. .1.994; ECHA. 1993 b). These analog results indicate low concern for reproductive toxicity in the target chemical by exceeding the 250 mg/kg-day thresholds. To further assess the potential for developmental toxicity, EPA evaluated two oral gavage studies on dipropylene glycol. A study on pregnant rats exposed during gestational day (GD) 6-15 reported a 18 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** developmental NOAEL of 2000 mg/kg-day and a LOAEL of 5000 mg/kg-day based on decreased fetal weight (OECD. 2001; BUA. .1.996; Bates et ah. 1992b; ECI 0b). A study on rabbits exposed to dipropylene glycol during GD 6-19 reported no adverse effects at the highest dose tested (1200 mg/kg-day), resulting in a NOAEL of 1200 mg/kg-day ("OECD. 2001; Bates et ah. 1.992a; ECU A. 1990a). These results indicate low concern for developmental toxicity by exceeding the 250 mg/kg-day threshold. 6.1.5 Genotoxicity EPA assessed experimental studies on genotoxicity as a potential indicator of genotoxic carcinogenicity. Three in vitro gene mutation studies resulted in negative findings from dipropylene glycol exposure with and without metabolic activation in Salmonella typhimurium ("ECH.A. 2004c; NTP. 2004; ECU A. 1992a) and in mouse lymphoma cells (ECHA. .1.988). Further, a mouse in vivo study indicated negative results for chromosomal aberrations in the form of micronucleated polychromatic erythrocytes ("OECD. 2001; ECHA. .1.999). These results indicate low concern for genotoxicity. 6.1.6 Carcinogenicity EPA assessed the potential for dipropylene glycol to cause carcinogenicity in mice and rats. Rats exposed to dipropylene glycol in drinking water for 2 years demonstrated no dose-related increase in cancer incidence and no cancer-related effects at the highest dose tested (3040 mg/kg-day in males, 2330 mg/kg-day in females), resulting in a negative finding for carcinogenicity (ECHA. 2004a. b; NTP. 2004). Similarly, mice exposed to dipropylene glycol in drinking water for two years also found no adverse effects at the highest dose tested (2390 mg/kg-day in males, 1950 mg/kg-day in females), resulting in a negative finding for carcinogenicity (ECHA. 2004a; NTP. 2004). These negative results indicate low concern for carcinogenicity. 6.1.7 Neurotoxicity While no traditional neurotoxicity studies were available for dipropylene glycol or closely-related analogs, EPA assessed the potential for neurotoxicity using relevant endpoints measured in acute and repeated dose studies and using predictions made by U.S. EPA's ToxCast.31 Several repeated dose studies in rats and mice exposed to dipropylene glycol orally reported no effects on the limited neurological endpoints that were evaluated (i.e., brain histopathology only). Dipropylene glycol did not produce histopathological brain lesions in rats at oral doses up to 12,800 mg/kg-day for 3 months or up to 3,040 mg/kg-day for 2 years. Similarly, no brain lesions were observed at oral doses up to 14,700 mg/kg-day for 3 months or up to 2,330 mg/kg-day for 2 years in mice ("ECHA. 2004b. d; NTP. 2004). Rats acutely exposed to dipropylene glycol by oral gavage noted decreased locomotor activity and ataxia for a few hours after exposure to the high dose of 5010 mg/kg, but the effects subsided by the first day of the observation period (E( >95d). ToxCast results for dipropylene glycol included 27 assays related to neurological functions. Bioactivity was not induced by dipropylene glycol in any assay. 31 fattps://actor, epa.gov/dashboard/ . Chemical specific assay list can be found at https://actor.epa.gOv/dashboard/#chemical/55934-93-5. 19 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** These data indicate there is low concern for neurotoxicity associated with dipropylene glycol. This finding is also supported by the low-hazard findings for other human health hazard endpoints, including, but not limited to, toxicity from acute exposures, reproductive toxicity, and developmental toxicity. 6.1.8 Skin Sensitization EPA assessed the potential for dipropylene glycol to cause skin sensitization using available experimental studies. A study on guinea pigs (ECHA. 19950 and two studies on humans (ECHA. 1995g; Johansen etaL, .1.995; Leberco Labs, .1.994) reported negative results, indicating low concern for skin sensitization by dipropylene glycol. 6.1.9 Skin Irritation EPA assessed dermal irritation using experimental results on rabbits and humans. Three studies demonstrated dipropylene glycol was negative for dermal irritation in rabbits ("ECHA. 1995 b. i; Leberco Labs. 1994). Further, a study on skin-sensitive humans demonstrated negative results for dermal irritation by dipropylene glycol (ECHA. 1997). while another study on humans indicated mild erythema in 4 of the 33 subjects at the 24-hour scoring (ECHA. 1995e). The results of these studies indicate that dipropylene glycol is of low concern for skin irritation. 6.1.10 Eye Irritation To assess potential for eye irritation, EPA used the results of two studies on rabbits. Rabbits exposed to dipropylene glycol displayed conjunctival redness and a subset displayed chemosis after one hour, but these results were fully reversible by 24 hours, leading to a negative result for eye irritation (ECHA. 1995f). These results are supported by another rabbit study with negative results (Leberco 6.1.11 Hazards to Potentially Exposed or Susceptible Subpopulations The above information supports a low human health hazard finding for dipropylene glycol based on low-concern criteria. This finding includes considerations such as the potential for developmental toxicity, reproductive toxicity, and acute or repeated dose toxicity that may impact potentially exposed or susceptible subpopulations. Based on the hazard information discussed in Section 6, EPA did not identify populations with greater susceptibility to dipropylene glycol. 6.2 Environmental Hazard EPA assessed environmental hazard for dipropylene glycol based on available experimental data and estimated toxicity values using the Ecological Structure Active (ECOSAR) Predictive Model.32 Appendix B contains a summary of the reasonably available environmental hazard data. 32https://www.epa.go v/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model . These results indicate low concern for eye irritation. 20 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 6.2.1 Acute Aquatic Toxicity EPA assessed environmental hazard from acute exposures to dipropylene glycol using experimental studies on dipropylene glycol and tripropylene glycol. No adverse effects were observed in aquatic invertebrates exposed to dipropylene glycol at the highest dose tested (100 mg/L), resulting in a NOAEL of 100 mg/L ("ECHA, 2002. 1995h). EPA used read-across from tripropylene glycol to assess toxicity to aquatic vertebrates and algae. No effects were observed in aquatic vertebrates exposed to tripropylene glycol, resulting in an LC50 greater than 1000 mg/L (ECHA. 1994a; QECD. .1.994). Similarly, no effects were observed in algae exposed to tripropylene glycol, resulting in an LC50 greater than 1000 mg/L (QECD. .1.994). These aquatic toxicity studies indicate low concern for acute aquatic exposure by exceeding the low-concern threshold of 100 mg/L. 6.2.2 Chronic Aquatic Toxicity EPA estimated environmental hazard from chronic aquatic exposures using ECOSAR. Chronic toxicity values estimated for aquatic vertebrates, aquatic invertebrates, and algae were 1,300 mg/L, 420 mg/L, and 370 mg/L, respectively. These toxicity values indicate that dipropylene glycol is expected to have low environmental hazard based on the low-concern criteria chronic aquatic toxicity threshold of 10 mg/L. 6.3 Persistence and Bioaccumulation Potential 6.3.1 Persistence Varied results are observed in the experimental ready test data presented in Appendix B. Because of the differences in the test conditions of the OECD ready test methods, some of this variability is likely a result of performance under different test designs rather than an inherent limitation of the biodegradability of the test substance. Given the varied results, EPA relied on studies on dipropylene glycol and tripropylene glycol to make a weight of the scientific evidence conclusion. An explanation of ready and inherent biodegradation tests is provided below. Ready biodegradation tests are stringent test methods in which a high concentration of test substance is evaluated using a non-adapted inoculum. Passing this type of test indicates that a chemical is likely to biodegrade in the environment and have low potential for persistence. However, not passing the ready criteria is not necessarily an indication that a chemical is recalcitrant or that it will be persistent in the environment. In contrast, inherent biodegradability tests use more favorable conditions to promote a high expected capacity for degradation, including the use of prolonged exposure periods and a low ratio of test substance to inoculum biomass. Passing this type of test indicates that a substance is inherently biodegradable but does not provide evidence for ready biodegradation. The available data included tests for both ready biodegradation and inherent biodegradation. An aerobic BOD5 test indicates dipropylene glycol is not rapidly biodegradable, with limited biodegradation observed (as O; consumption) after 5 days (MeshakoetaL 1999). Additionally, tripropylene glycol was tested in three ready tests (OECD Guidelines 301C, OECD 30 IB and OECD 30ID) that reported < 5% degradation over 28-day incubation periods, indicating that it is not readily biodegradable (OECD. .1.994; EC 93a. 1991b). However, in another OECD Guideline 30ID test, tripropylene glycol reached 69% O2 consumption after 28 days and just missed the 10-day 21 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** window criterion at 59% in 11 days under aerobic conditions (ECHA. .1.99la). In addition, both dipropylene glycol and tripropylene glycol reached > 81% O2 consumption after 28 days in the OECD Guideline 301F test, meeting the criteria for ready biodegradation but not meeting the 10-day window under aerobic conditions (ECHA. 2007a. c, 1994b). These data suggest that dipropylene glycol is biodegradable and may be readily biodegradable under the right conditions. Results from additional aerobic studies, including the inherent biodegradability test (OECD Guideline 3 02A) and a seawater biodegradability test (OECD Guideline 306), provide further support that dipropylene glycol has the capacity to biodegrade under environmental conditions (ECHA. 2007d. 1994b). Furthermore, microbial inhibition tests indicate that these substances are non-toxic to microbial populations found in sewage treatment plants (ECHA. 20.1.0. 1992b). Based on the weight of the scientific evidence, the data suggest dipropylene glycol is expected to biodegrade under aerobic conditions. Although under some test conditions this chemical may not meet the benchmark for ready biodegradation, both primary and ultimate biodegradation of this substance has been demonstrated using a variety of standard and non-standard test methods. No quality experimental studies were available to assess anaerobic biodegradation. Though BIOWIN modeling did not predict this chemical to anaerobically biodegrade quickly, these results do not indicate this chemical would not anaerobically biodegrade. Dipropylene glycol's low-hazard results for environmental and mammalian toxicity, and evidence of aerobic biodegradation, indicate low concern for this chemical if present in anaerobic environments. No degradation products of concern were identified for this chemical substance. The available biodegradation results meet the low-concern threshold and indicate this chemical has low persistence. 6.3.2 Bioaccumulation Potential Based on the estimated bioaccumulation factor (BAF) value of 0.9 using the Estimation Programs Interface (EPI) Suite models,33 dipropylene glycol is expected to have low potential for bioaccumulation in the environment based on the low-concern threshold of less than 1000. Because of dipropylene glycol's ability to biodegrade and its low BAF value, the chemical has low concern for persistence and bioaccumulation. 33 https://www.epa.gov/tsca-screeiiiiig-tools/epi-suitetm-estimation-program-iiiterface 22 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 7. Exposure Characterization EPA considered reasonably available information on exposure for dipropylene glycol. In general, there is limited information on exposure for low-hazard chemicals. EPA consulted sources of exposure and use information that include CDR and other databases and public sources. EPA used these sources (described in Table A.2) to inform intended, known, or reasonably foreseen uses. Dipropylene glycol is a solvent used in processing (incorporation into an article and into a formulation, mixture, or product) in the industrial printing ink manufacturing sector and as a reactant in plastic and resin manufacturing. It is used in a variety of industrial, consumer, and commercial uses, as shown in Table 3. Non-TSCA uses, including those excluded under TSCA section 3(2), are beyond the scope of this assessment (See Table A.3). Under the conditions of use identified in Table 3, EPA assessed the potential exposure to the following categories: the environment, the general population, and potentially exposed or susceptible subpopulations including workers, consumers, and children. 7.1 Production Volume Information Production volume information for dipropylene glycol is based on an analysis of CDR data reported from 1986-2015.34 In reporting years 1986, 1990, and 1994, aggregate production volume for dipropylene glycol was between 50,000,000 and 100,000,000 lbs., and in reporting years 1998, 2002, and 2006 aggregate production volume was between 100,000,000 and 500,000,000 lbs. Between reporting years 2012 and 2015, aggregate production volume for dipropylene glycol was between 100,000,000 and 250,000,000 lbs. The exact amount is available for one year, 2011, in which 201,501,161 lbs. of dipropylene glycol was manufactured or imported. In general, since 2011, production volume has remained relatively stable. 7.2 Exposures to the Environment EPA expects most exposures to the environment to occur during the manufacture, import, processing, and industrial, commercial, and consumer uses of dipropylene glycol. Exposure is also possible from other conditions of use, such as distribution and disposal. These activities could result in releases of dipropylene glycol to media including surface water, landfills, and air. EPA expects high levels of removal of dipropylene glycol during wastewater treatment (either directly from the facility or indirectly via discharge to a municipal treatment facility or Publicly Owned Treatment Works (POTW)). Further, dipropylene glycol is expected to have low persistence (aerobic biodegradation is discussed in Section 6.3.1) and has the potential to break down in the environment to carbon dioxide and water. Therefore, any release of this chemical is expected to break down, reducing exposure to aquatic organisms in the water column and groundwater sources of 34 Hie CDR requires manufacturers (including importers) to report information on the chemical substances they produce domestically or import into the U.S. above 25,000 lb. per site per year. 12 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** drinking water, including well water. Based on the estimated log Koc (Table 2 of Section 3), dipropylene glycol is expected to have negligible adsorption to sediment, reducing the potential for toxicity to benthic organisms. Dipropylene glycol's biodegradability during treatment processes will reduce the exposure potential to aquatic organisms. If disposed of in a landfill, this chemical is expected to degrade under aerobic conditions (aerobic biodegradation is discussed in Section 6.3.1). If incineration releases during manufacturing and processing occur, EPA expects significant degradation of dipropylene glycol to the point that it will not be present in air. 7.3 Exposures to the General Population EPA expects the general population is unlikely to be exposed to dipropylene glycol from the potential environmental releases described above. Air exposure is unlikely from incineration. If dipropylene glycol is present in the air from volatilization, it is expected to be reduced because of its short atmospheric half-life of 4 hours (see Table 2 in Section 3). With the exception of time immediately following a release, dipropylene glycol is unlikely to be present in surface water because it will degrade (discussed in Section 6.3.1), reducing the potential for the general population to be exposed by oral ingestion or dermal exposure. Given the low bioaccumulation or bioconcentration potential of dipropylene glycol, oral exposure to dipropylene glycol via fish ingestion is unlikely. 7.4 Exposures to Potentially Exposed or Susceptible Subpopulations EPA identified workers, children, and consumers as potentially exposed or susceptible subpopulations based on greater exposure to dipropylene glycol than the general population during manufacturing, processing, distribution, use and disposal. EPA identified children (including any adults working closely with children) as a population that may experience greater exposure to dipropylene glycol than the general population during use of finger paints and toys. EPA also identified consumers as a population that may experience greater exposure to dipropylene glycol than the general population through use of ink, toner, and colorant products; laundry and dishwashing products; and cleaning and furnishing care products, for example. 7.4.1 Exposures to Workers Based on its reported physical form and measured melting point (Table 2), dipropylene glycol is a liquid under ambient conditions. Based on dipropylene glycol's conditions of use (Table 3), workers may be exposed to liquids through direct dermal contact with the substance and inhalation of aerosols if they are generated. Based on its measured vapor pressure (Table 2), dipropylene glycol is expected to be volatile at ambient temperatures, and therefore workers may be exposed through inhalation of vapors. If dipropylene glycol is in a dilute form, the estimated Henry's Law constant for dipropylene glycol suggests volatilization from water and aqueous solutions is expected to be minimal. Workers may be exposed to dipropylene glycol in manufacturing, processing, distribution, use and disposal. 13 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 7.4.2 Exposures to Consumers Consumers may be exposed to dipropylene glycol through the use of cleaning and furnishing care products, laundry and dishwashing products, and ink, toner, and colorants products, for example. For all these uses, if dermal contact does occur, dipropylene glycol is expected to have minimal absorption through the skin based on its molecular weight, water solubility and partitioning coefficients (Section 3) and experimental data (Section 6.1.1). If the chemical is in an aerosol product and inhalation exposure occurs, dipropylene glycol's absorption from the lungs is likely. EPA does not include intentional misuse, such as people drinking products containing this chemical, as part of the known, intended or reasonably foreseen conditions of use that could lead to an exposure (82 FR 33726). Thus, oral exposures will be incidental (meaning inadvertent and low in volume). Dipropylene glycol is expected to be metabolized and excreted, further reducing the duration of exposure. 7.4.3 Exposures to Children Children may be exposed to dipropylene glycol through use of finger paints. Given the molecular weight, water solubility, and partitioning coefficients in Table 2 and the absorption data in Section 6.1.1, this chemical is expected to be poorly absorbed through the skin. Dipropylene glycol is likely to be present in a water-based solution in finger paints. Based on the predicted Henry's Law constant (Section 3), dipropylene glycol's volatilization from water and aqueous solutions is expected to be minimal from these products, reducing inhalation exposures from volatilization to children. While using these products, children may rub their eyes or incidentally ingest the product. Children may also be exposed to dipropylene glycol when playing with wooden toys. A 2005 survey of chemical substances in consumer products conducted by the Danish Ministry of the Environment detected the chemical in one of 15 wooden toys (Danish EPA, 2005). The study identified chemicals in the wooden toys by soaking the toys in artificial saliva. While the study then estimated risk for a subset of the chemicals detected in the wooden toys, such estimates were not calculated for dipropylene glycol due to the chemicals low hazard profile. Additionally, based on the information in Section 3 and Section 6.1.1, children's exposure via dermal pathways is expected to be minimal, and ingestion is expected to result in metabolism and excretion. 7.5 References Danish EPA. (2005). Migration and health assessment of chemical substances in surface treated wooden toys. Retrieved from https://www2.mst.dk/Uclgiv/publications/2005 ^ ' VI \ \. 6Zpdff87-7614-713-4.pdf 14 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 8. Summary of Findings EPA has used reasonably available information on the following statutory and regulatory criteria and considerations to screen dipropylene glycol against each of the priority designation considerations in 40 CFR 702.9(a), listed below and discussed individually in this section, under its conditions of use: the hazard and exposure potential of the chemical substance (See Sections 6 and 7); persistence and bioaccumulation (See Section 6.3); potentially exposed or susceptible subpopulations (See Section 7.4); storage near significant sources of drinking water (See Section 8.4); conditions of use or significant changes in the conditions of use of the chemical substance (See Section 5); the chemical substance's production volume or significant changes in production volume (See Section 7.1); and other risk-based criteria that EPA determines to be relevant to the designation of the chemical substance's priority. EPA conducted a risk-based, screening-level review based on the criteria and other considerations above and other relevant information described in 40 CFR 702.9(c) to inform the determination of whether the substance meets the standard of a high-priority substance. High-priority substance means a chemical substance that EPA determines, without consideration of costs or other non-risk factors, may present an unreasonable risk of injury to health or the environment because of a potential hazard and a potential route of exposure under the conditions of use, including an unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant by EPA (40 CFR 702.3). This section explains the basis for the proposed designation and how EPA applied statutory and regulatory requirements, addressed rationales and reached conclusions. 8.1. Hazard and Exposure Potential of the Chemical Substance Approach: EPA evaluated the hazard and exposure potential of dipropylene glycol. EPA used this information to inform its proposed determination of whether dipropylene glycol would meet the statutory criteria and considerations for proposed designation as a low-priority substance. Hazard potential: For dipropylene glycol's hazard potential, EPA gathered information for a broad set of human health and environmental endpoints described in detail in Section 6 of this document. EPA benchmarked this information against the low-concern thresholds. EPA found that dipropylene glycol is of low concern for human health and environmental hazard across the range of endpoints in this low-concern criteria. Exposure potential: To understand exposure potential, EPA gathered information on physical-chemical properties, production volumes, and the types of exposures likely to be faced by workers, the general population, consumers, and children (discussed in Sections 3 and 7). EPA also gathered information on environmental releases. EPA identified workers, the general population, consumers, children, and the environment as most likely to experience exposures. EPA determined that while the general 15 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** population, consumers, children and workers may be exposed to dipropylene glycol, exposure by the dermal pathway is limited by dipropylene glycol's physical-chemical properties. If ingestion occurs, dipropylene glycol is expected to be quickly metabolized and excreted, reducing the duration of exposure. Inhalation of dipropylene glycol from dilute products is expected to be minimal; however, workers may be exposed to vapors of neat dipropylene glycol. If dipropylene glycol is released into the environment, its exposure potential will be reduced through biodegradation under aerobic conditions. Rationale: EPA determined that while workers, consumers, and children could be exposed to dipropylene glycol during processing, manufacturing, distribution, use, or disposal, these exposures do not pose a significant risk because of the chemical's low-hazard results across a range of endpoints (discussed in Section 6). In summary, the concern for exposure is mitigated by the low-hazard profile of this chemical. Proposed Conclusion: Based on an initial analysis of reasonably available hazard and exposure information, EPA proposes to conclude that the risk-based, screening-level review under 40 CFR 702.9(a)(1) does not support a finding that dipropylene glycol meets the standard for a high-priority substance. The reasonably available hazard and exposure information described above provides sufficient information to support this proposed finding. 8.2. Persistence and Bioaccumulation Approach: EPA has evaluated both the persistence and bioaccumulation potential of dipropylene glycol based on a set of EPA and internationally accepted measurement tools and thresholds that are indicators of persistence and bioaccumulation potential (described in Section 6). These endpoints are key components in evaluating a chemical's persistence and bioaccumulation potential. Rationale: EPA review of experimental data indicates dipropylene glycol is biodegradable under aerobic conditions (discussed in Section 6.3.1). EPA's EPI Suite models indicate a low potential for bioaccumulation and bioconcentration. Proposed Conclusion: Based on an initial screen of reasonably available information on persistence and bioaccumulation, EPA proposes to conclude that the screening-level review under 40 CFR 702.9(a)(2) does not support a finding that dipropylene glycol meets the standard for a high priority substance. The reasonably available persistence and bioaccumulation information described above provides sufficient information to support this proposed finding. 8.3. Potentially Exposed or Susceptible Subpopulations Approach: TSCA Section 3(12) states that the "term 'potentially exposed or susceptible subpopulation' means a group of individuals within the general population identified by the Administrator who, due to either greater susceptibility or greater exposure, may be at greater risk than the general population of adverse health effects from exposure to a chemical substance or mixture, such as infants, children, pregnant women, workers, or the elderly." EPA identified workers engaged in the manufacturing, processing, distribution, use and disposal of dipropylene glycol as a potentially 16 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** exposed or susceptible subpopulation (described in more detail in Section 7). EPA also identified children as a population that may experience greater exposure to dipropylene glycol than the general population during use of finger paints and toys. Consumers are also a potentially exposed subpopulation because of their use of products such as ink, toner, and colorant products and laundry and dishwashing products, as shown in Table 3. Rationale: EPA did not identify hazard effects for this chemical that would make any population susceptible. EPA expects workers, consumers, and children to have a higher exposure to dipropylene glycol than the general population. Higher exposure to children (and adults working closely with children) could result from use of finger paints containing dipropylene glycol, which might lead to inadvertent eye contact. Children could also be exposed to dipropylene glycol via ingestion while playing with wooden toys. Because of the chemical's low-concern hazard properties, this exposure does not pose a significant increase in risk. Proposed Conclusion: Based on the Agency's understanding of the conditions of use and expected users such as potentially exposed or susceptible subpopulations, EPA proposes to conclude that the screening-level review under 40 CFR 702.9(a)(3) does not support a finding that dipropylene glycol meets the standard for a high-priority substance. While the conditions of use will result in an increase in exposures to certain populations, the consistently low-concern hazard profile of dipropylene glycol provides sufficient evidence to support a finding of low concern. The reasonably available information on conditions of use, hazard, and exposure described above provides sufficient information to support this proposed finding. 8.4. Storage near Significant Sources of Drinking Water Approach: In Sections 6 and 7, EPA explains its evaluation of the elements of risk relevant to the storage of dipropylene glycol near significant sources of drinking water. For this criterion, EPA focused primarily on the chemical's potential human health hazards, including to potentially exposed or susceptible subpopulations, and environmental fate properties, and explored a scenario of a release to a drinking water source. EPA also investigated whether the chemical was monitored for and detected in a range of environmental media. The requirement to consider storage near significant sources of drinking water is unique to prioritization under TSCA Section 6(b)(1)(A). Rationale: In terms of health hazards, dipropylene glycol is expected to present low concern to the general population, including susceptible subpopulations, across a spectrum of health endpoints. In the event of an accidental release into a surface drinking water source, dipropylene glycol is expected to be water soluble (see Section 3) and not expected to persist (see Section 6) in the drinking water supply. In the event of an accidental release to land, the estimated log Koc indicates this substance is highly mobile in soils, increasing its potential for leaching into groundwater, including well water. The fate and transport evaluation indicates dipropylene glycol is unlikely to partition into sediment, predicted to biodegrade under aerobic conditions (see Section 3), and unlikely to bioaccumulate (see Section 6), minimizing the likelihood that the chemical would be present in sediment or groundwater to pose a longer-term drinking water contamination threat. Further, as explained in section 6.1.3, repeated exposures of mice and rats to dipropylene glycol through the 17 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** drinking water exposure pathway indicate low concern for exposure through drinking water to this chemical. A sudden release of large quantities of the chemical near a drinking water source could have immediate effects on the usability of a surface drinking water source. If such a release were to occur, two primary factors would operate together to reduce concern. First, the chemical would be expected to present low concern to the general population, including susceptible subpopulations, across a spectrum of health endpoints (see Section 6). Second, dipropylene glycol would degrade in an aerobic environment (see Section 6). Together, these factors mean that any exposures to this chemical through drinking water sources would be short-lived, and that if ingestion were to take place, concern for adverse health effects would be low. EPA also explored whether the chemical had been identified as a concern under U.S. environmental statutes in the past. EPA searched lists of chemicals and confirmed that dipropylene glycol does not appear on these lists. The lists reviewed include EPA's List of Lists ("https://www.epa.gov/sites/production/files/2015-03/documents/list of lists.pdf). EPA also searched the lists of chemicals included in the National Primary Drinking Water Regulations and the Unregulated Contaminant Monitoring Rule (UCMR) under the Safe Drinking Water Act (SDWA). Proposed Conclusion: Based on a qualitative review of a potential release near a significant source of drinking water, EPA proposes to conclude that the screening-level review under 40 CFR 702.9(a)(4) does not support a finding that dipropylene glycol meets the standard for a high-priority substance. The reasonably available information on storage near significant sources of drinking water described above provides sufficient information to support these proposed findings. 8.5. Conditions of Use or Significant Changes in Conditions of Use of the Chemical Substance Approach: EPA evaluated the conditions of use for dipropylene glycol and related potential exposures. Rationale: EPA evaluated the conditions of use of dipropylene glycol (see Section 5 and Appendix A) and found it to have a broad range of conditions of use. EPA expects that even if the conditions of use were to expand beyond activities that are currently known, intended, and reasonably foreseen, the outcome of the screening review would likely not change and would not alter the Agency's conclusion of low concern. EPA bases this expectation on dipropylene glycol's consistently low- concern hazard characteristics across the spectrum of hazard endpoints and regardless of a change in the nature or extent of its use and resultant increased exposures. Proposed Conclusion: EPA's qualitative evaluation of potential risk does not support a finding that dipropylene glycol meets the standard for a high-priority substance based on its low-hazard profile under the current conditions of use. EPA proposes to find that even if conditions of use broaden, resulting in an increase in the frequency or amount of exposures, the analysis conducted to support the screening-level review under 40 CFR 702.9(a)(5) would not change significantly. In particular, the analysis of concern for hazard, which forms an important basis for EPA's findings, would not be 18 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** impacted by a change in conditions of use. Therefore, such changes would not support a finding that dipropylene glycol meets the standard for a high-priority substance. The reasonably available information on conditions of use, or significant changes in conditions of use, described above provides sufficient information to support this proposed finding. 8.6. The Volume or Significant Changes in Volume of the Chemical Substance Manufactured or Processed Approach: EPA evaluated the current production volumes of dipropylene glycol (Section 7.1) and related potential exposures (Section 7.2 through 7.4). Rationale: EPA used reasonably available information on production volume (see Appendix A) in considering potential risk. It is reasonably foreseeable that designation of dipropylene glycol as a low- priority substance could result in increased use and higher production volumes. EPA expects, however, that any changes in dipropylene glycol's production volume would not alter the Agency's assessment of low concern given the low-hazard profile of the chemical. EPA bases this expectation on dipropylene glycol's consistently low-concern hazard characteristics across the spectrum of hazard endpoints and regardless of a significant change in the volume of the chemical manufactured or processed and resultant increased exposures. Proposed Conclusion: Based on this screening criteria under 40 CFR 702.9(a)(6), EPA proposes to find that even if production volumes increase, resulting in an increase in the frequency or level of exposures, dipropylene glycol does not meet the standard for a high-priority substance. The reasonably available information on production volume, or significant changes in production volume, described above provides sufficient information to support this proposed finding. 8.7. Other Considerations EPA did not identify other considerations for the screening review to support the proposed designation of dipropylene glycol as a low-priority substance. 19 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 9. Proposed Designation Based on a risk-based- screening-level review of the chemical substance and, when applicable, relevant information received from the public and other information as appropriate and consistent with TSCA section 26(h) and (i), EPA is proposing to designate dipropylene glycol as a low-priority substance as it does not meet the statutory criteria for a high-priority substance. 20 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Appendix A: Conditions of Use Characterization EPA gathered information on and related to conditions of use including uses of the chemical, products in which the chemical is used, types of users, and status (e.g., known, regulated). A.1. CDR Manufacturers and Production Volume The Chemical Data Reporting (CDR) rule (previously known as the Inventory Update Rule, or IUR), under TSCA section 8, requires manufacturers (including importers) to report information on the chemical substances they produce domestically or import into the U.S., generally above a reporting threshold of 25,000 lb. per site per year. According to the 2016 Chemical Data Reporting (CDR) database, 55 companies manufactured or imported dipropylene glycol at 56 sites for reporting year 2015. Individual production volumes were withheld but may be available in later releases of the 2016 data. Table presents the historic production volume of dipropylene glycol from the CDR (previously known as the Inventory Update Rule, or IUR) from 1986-2015. In reporting years 1986, 1990, and 1994, aggregate production volume for dipropylene glycol was between 50,000,000 and 100,000,000 lbs., and in reporting years 1998, 2002, and 2006 aggregate production volume was between 100,000,000 and 500,000,000 lbs. Between reporting years 2012 and 2015, aggregate production volume for dipropylene glycol was between 100,000,000 and 250,000,000 lbs. The exact amount is available for one year, 2011, in which 201,501,161 lbs. of dipropylene glycol was manufactured or imported. In general, since 2011, production volume has remained relatively stable without significant increases or decreases. Table A. 1 : 1986-2015 National Production Volume Data for Dipropylene glycol (Non-Confidential Production Volume in Pounds ) 1986 1990 1994 1998 2002 2006 2011 2012 2013 2014 2015 >50M - >5M - >50M - >100M >100M 100M- 201,501,161 100M- 100M- 100M- 100M- 100M 10M 100M -500M -500M <500 M 250 M 250 M 250 M 250 M Source(s): EPA (2018a; 2017b; 2006; 2002) Note(s): M = Million I ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** A.2. Uses A.2.1 Methods for Uses Table Section A. 1 provides a list of known uses of dipropylene glycol, organized by category of use. To compile the uses, EPA searched publicly available databases listed in Error! Reference source not found, and conducted additional Google searches to clarify uses. Search terms differed among databases because of different search term requirements for each database (i.e., some databases search by CASRN while others search by chemical name). Table A.2: Sources Searched for Uses of Dipropylene Glycol Title Author and Year Search Term(s) Found Use Information? 1 Sources searched for all use reports California Links to Pesticides Data California Dept of Pesticide Regulation (2013) 25265-71-8 Yes Canada Chemicals Management Plan information sheets Government of Canada (2018) Dipropylene glycol; DPG No Chemical and Product Categories (CPCat) CPCat (2019) 25265-71-8 Yes ChemView2 EPA (2018a) 25265-71-8 Yes Children's Safe Product Act Reported Data Washington State Dept. of Ecology (2018) 25265-71-8 No Consumer Product Information Database (CPID) DeLima Associates (2018) 25265-71-8 Yes Danish surveys on chemicals in consumer products Danish EPA (2018) N/A, there is no search but report titles were checked for possible information on the chemical No Datamyne Descartes Datamyne (2018) Dipropylene glycol Yes DrugBank DrugBank (2018b) 25265-71-8 Yes European Chemicals Agency (ECHA) Registration Dossier ECHA (2018a; 2018b) 25265-71-8 Yes eChemPortal2 OECD (2018) 25265-71-8 Yes Envirofacts2 EPA (2018b) 25265-71-8 No Functional Use Database (FUse) EPA (2017a) 25265-71-8 Yes Kirk-Othmer Encyclopedia of Chemical Technology Kirk-Othmer (2006) Dipropylene glycol No Non-Confidential 2016 Chemical Data Reporting (CDR) EPA (2017b) 25265-71-8 Yes PubChem Compound Kimetal. (2016) 25265-71-8 Yes Safer Chemical Ingredients List (SCIL) EPA (2018d) 25265-71-8 Yes II ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.2: Sources Searched for Uses of Dipropylene Glycol Title Author and Year Search Term(s) Found Use Information? 1 Synapse Information Resources2 Synapse Information Resources (2009) Dipropylene glycol Yes Resource Conservation and Recovery Act (RCRA) EPA (2018c) Dipropylene glycol No Scorecard: The Pollution Information Site GoodGuide (2011b) 25265-71-8 Yes Skin Deep Cosmetics Database EWG (2018a, 2018b) Uses for CAS RN 110-98-5, with the chemical name listed as "Dipropylene Glycol." EWG did not have search results for CAS RN 25265-71-8 or "1,1'dimethyldiethylene glycol." Toxics Release Inventory (TRI) EPA (2018e) 25265-71-8 No TOXNET2 NLM (2018a) 25265-71-8 Yes Ullmann's Encyclopedia of Industrial Chemistry Ullmann's (2000) Dipropylene glycol No Additional Sources Identified from Reasonably Available Information Boscia Boscia (2018) Incidentally identified while researching details of this chemical's uses and products. Yes Cetaphil Cetaphil (2018) CVS CVS (2018) Dove Dove (2018) The Dow Chemical Company Dow (2009) Medline Medline.com (2009) National Archives and Records Information National Archives and Records Administration (2018) National Pesticide Information Retrieval System (NPIRS) NPIRS (2018) Neutrogena Neutrogena (2018a) Shiseido Shiseido (2018) Skinfood Skinfood (2018) Note(s): 1. If use information was found in the resource, it will appear in Table A.3 unless otherwise noted. 2. This source is a group of databases; thus the exact resource(s) it led to will be cited instead of the database as whole. The U.S. Patent and Trademark Office has an online database that shows 41,147 patents referencing "dipropylene glycol" (USPTO 2018a). Although patents could be useful in determining reasonably foreseen uses, it is difficult to confirm whether any of the patented technologies are currently in use. Uses inferred from patents containing dipropylene glycol were not included in Table A.3. Note that the uses in Table A.3 that are covered under TSCA are included in Section 5, Table 3 of this document. A.2.2 Uses of Dipropylene Glycol mi ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References | TSCA Conditions of Use: Air Care Products CDR reports use of liquid dipropylene glycol in consumer air care products at concentrations of less than 30 percent and at least 90 percent by weight (EPA 2017b). DeLima Associates (2013a); GoodGuide (2011a); CPCat (2019); ECHA (2018b) Air freshener Consumer Pollution Scorecard identifies use of dipropylene glycol in non-aerosol air fresheners. CPCat lists the use of dipropylene glycol in air fresheners, deodorizers, air cleaners and anti-odor agents not including filters. CPID lists the use of dipropylene glycol in air fresheners, including car air fresheners. The ECHA registration dossier indicates the use of dipropylene glycol in air care products available for consumer use. Expected users are consumer based on inclusion in CPID and GoodGuide's consumer uses. DeLima Associates (2015g); CPCat (2019) Candle Consumer CPCat lists the use of dipropylene glycol in decor candles and candle holders. CPID generally includes products for consumer use; therefore, the expected user is a consumer. TSCA Conditions of Use: Cleaning and Furnishing Care Products CDR reporting shows use of liquid dipropylene glycol in consumer and commercial cleaning and furnishing care products at concentrations of less than 30 percent by weight (EPA 2017b). CPCat (2019) Automotive care Consumer, commercial CPCat lists the use of dipropylene glycol in car care and cleaning products. Expected users are not listed but are assumed to be consumer and commercial for automotive care. Bathroom cleaner Consumer DeLima Associates (2015n) CPID generally includes products for consumer use; therefore, the expected user is a consumer. ECHA (2018b) Boat cleaner Commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional boat cleaners. Expected users are commercial based on inclusion in ECHA's uses by professional workers. IV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References DeLima Associates (2013c); ECHA (2018b) Carpet and upholstery cleaner Consumer, commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional carpet cleaners. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are commercial based on inclusion in ECHA's uses by professional workers. CPCat (2019); ECHA (2018b) Car wax Commercial CPCat lists the use of dipropylene glycol in car wax (polishing agents) for automotive care. The ECHA registration dossier indicates the use of dipropylene glycol in professional car wash and dewaxing products. Expected users are commercial based on inclusion in ECHA's uses by professional workers. CPCat (2019) Degreasers Consumer, commercial CPCat lists the use of dipropylene glycol in degreasers, including cold-degreasing, de-waxing, and de-polishing. Expected users are not listed but are expected to be consumer and commercial for degreasers. ECHA (2018b) Descaling agent Commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional descaling agents. Expected users are commercial based on inclusion in ECHA's uses by professional workers. DeLima Associates (2015f); CPCat (2019); ECHA (2018b) Drain cleaner Commercial CPCat lists the use of dipropylene glycol in drain cleaners. The ECHA registration dossier indicates the use of dipropylene glycol in professional drain cleaners. CPID lists this product for professional use; therefore, the expected users are commercial. DeLima Associates (2014c); ECHA (2018b) Floor cleaner Consumer, commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional floor cleaners and floor strippers. CPID lists this product for professional and general use; therefore, the expected users are consumer and commercial. V ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Floor polish Consumer, commercial DeLima Associates (2015m); GoodGuide (2011a); CPCat (2019) Pollution Scorecard identifies use of dipropylene glycol in floor polish. CPCat lists the use of wax and polishing agents for floors. Expected users are consumer based on inclusion in CPID and GoodGuide's consumer uses. Expected users are consumer and commercial based on inclusion in ECHA's uses by professional workers. Furniture polish Consumer, commercial DeLima Associates (2008a) CPID generally includes products for consumer use; therefore, the expected users are consumer and commercial. General purpose cleaner Commercial ECHA (2018b) The ECHA registration dossier indicates the use of dipropylene glycol in general purpose cleaner. Expected users are commercial based on inclusion in ECHA's uses by professional workers. Glass cleaner Consumer, commercial DeLima Associates (2015o); CPCat (2019); ECHA (2018b) CPCat lists the use dipropylene glycol in glass and window cleaner/ polish. The ECHA registration dossier indicates the use of dipropylene glycol in glass cleaner. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are also commercial based on inclusion in ECHA's uses by professional workers. Granite cleaner and polish Consumer DeLima Associates (2015j) CPID generally includes products for consumer use; therefore, the expected user is a consumer. Hard surface cleaner Consumer, commercial DeLima Associates (2015d) CPID lists this product for professional and general use; therefore, the expected users are consumer and commercial. VI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Industrial cleaning Commercial, industrial CPCat lists the use dipropylene glycol in industrial, specialized cleaning and washing activities, including for commercial clients. Expected users are commercial and industrial based on CPCat's user classification. ECHA (2018b) Kitchen cleaner Commercial The ECHA registration dossier indicates the use of dipropylene glycol in kitchen cleaners. Expected users are commercial based on inclusion in ECHA's uses by professional workers. ECHA (2018b) Oven/ grill cleaner Commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional oven and grill cleaner. Expected users are commercial based on inclusion in ECHA's uses by professional workers. CPCat (2019) Rust removers Consumer, commercial CPCat lists the use of dipropylene glycol in rust removers and corrosion inhibitors. Expected users are not listed but are expected to be consumer and commercial for rust removers. Shower cleaner Consumer DeLima Associates (2015k) CPID generally includes products for consumer use; therefore, the expected user is a consumer. Soap, cleaning compound, and toilet preparation manufacturing Industrial EPA (2017b); Dow (2009) CDR reports show use of dipropylene glycol as a solvent, surface active agent, and odor agent in the manufacture of soap, cleaning compound, and toilet preparations. Dow identifies use in industrial soaps. Expected users are industrial based on CDR's Industrial Processing and Use report. VII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Stain remover DeLima Associates (2017a) Consumer CPID generally includes products for consumer use; therefore, the expected user is a consumer. DeLima Associates (2015c); CPCat (2019) Toilet bowl cleaner Consumer CPCat lists the use of dipropylene glycol in sanitation agents for cleaning and washing of toilets. CPID generally includes products for consumer use; therefore, the expected user is a consumer. TSCA Conditions of Use: Construction CPCat (2019) Brick-layering Industrial CPCat lists the use of dipropylene glycol in bricklaying. Expected users are industrial based on CPCat's user classification. CPCat (2019) Building construction Industrial CPCat lists the use of dipropylene glycol in the construction of buildings and civil engineering works, and in construction materials, including filling, padding and insulation materials (including to protect from noise, cold, electric) Expected users are industrial based on CPCat's user classification. CPCat (2019) Building glass Industrial CPCat lists the use of dipropylene glycol in glass building material, with use as a colorant detected. Expected users are industrial based on CPCat's user classification. CPCat (2019) Demolition Industrial CPCat lists the use of dipropylene glycol in "demolition and wrecking of buildings." Expected users are industrial based on CPCat's user classification. VIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Floor and wall covering Industrial CPCat lists the use of dipropylene glycol in floor and wall covering for building. Expected users are industrial based on CPCat's user classification. CPCat (2019) Plumbing installation Industrial CPCat lists the use of dipropylene glycol in plumbing, heat and air-conditioning installation. Expected users are industrial based on CPCat's user classification. CPCat (2019) Ship building Industrial CPCat lists the use of dipropylene glycol in the building and repairing of pleasure and sporting boats, ships and other floating structures. Expected users are industrial based on CPCat's user classification. TSCA Conditions of Use: Energy and Resources CPCat (2019) Automotive fuel Industrial CPCat lists the use of dipropylene glycol in the retail sale of automotive fuel in specialized stores. Expected users are industrial based on CPCat's user classification. CPCat (2019) Crude petroleum and natural gas extraction Industrial CPCat lists the use of dipropylene glycol in the extraction of crude petroleum and natural gas. Expected users are not stated but expected to be industrial for tracking. IX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Fracking Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in resource extraction of gas through fracking. Expected users are not stated but expected to be industrial for fracking. Fuel additive Industrial CPCat (2019) CPCat lists the use of dipropylene glycol as a fuel additive. Expected users are not stated but expected to be industrial for fuel additives. Mining Industrial CPCat (2019); ECHA (2018b) CPCat lists the use of dipropylene glycol in mining support service activities. The ECHA registration dossier indicates the use of dipropylene glycol in mining. Expected users are industrial based on CPCat's user classification. Test drilling and boring Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in test drilling and boring. Expected users are industrial based on CPCat's user classification. TSCA Conditions of Use: Food and Beverages Food and beverage service activities1 Unknown CPCat (2019) CPCat lists the use of dipropylene glycol in food and beverage service activities. Expected users are industrial based on CPCat's user classification. X ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References | TSCA Conditions of Use: Industrial Uses CPCat (2019) Coloring agents Industrial CPCat lists the use of dipropylene glycol in industrial colorants, color agents, dyestuff, and color pigments. Expected users are industrial, based on CPCat's user classification. CPCat (2019) Motor vehicle maintenance and repair Industrial CPCat lists the use of dipropylene glycol in the maintenance and repair of motor vehicles, including in bodywork repair and painting. Expected users are industrial based on CPCat's user classification. Oil and gas exploration/ production Industrial ECHA (2018b) The ECHA registration dossier indicates the use of dipropylene glycol in oil and glass exploration or production products. Expected users are industrial based on inclusion in ECHA's uses at industrial sites. CPCat (2019) Printing Industrial CPCat lists the use of dipropylene glycol in printing and reproduction of recorded media, printing. Expected users are industrial based on CPCat's user classification. CPCat (2019); ECHA (2018b) Sewage treatment Industrial CPCat lists the use of dipropylene glycol in "sewage and refuge disposal, sanitation and similar activities." The ECHA registration dossier indicates the use of dipropylene glycol in sewage treatment. Expected users are industrial based on CPCat's user classification. XI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Surfactant Industrial EPA (2017b); CPCat(2019); ECHA (2018b) CDR reports show use of dipropylene glycol as a surfactant in wholesale and retail trade. CPCat lists the use of dipropylene glycol as a surfactant in detergents and cleaning and washing agents. The ECHA registration dossier indicates the use of dipropylene glycol as a surfactant in industrial sites. Expected users are industrial based on CDR's Industrial Processing and Use report. TSCA Conditions of Use: Laundry and Dishwashing Products CDR reports show use of liquid dipropylene glycol in consumer and commercial laundry and dishwashing products. CDR identifies concentrations (by weight) of less than one percent in consumer products and at least one percent but less than 30 percent in consumer and commercial products (EPA 2017b). Dishwasher cleaner Consumer DeLima Associates (2015b); CPCat (2019) CPCat lists the use of dipropylene glycol in cleaning and washing agents for dishwashing machines. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Dishwasher detergent Consumer, commercial DeLima Associates (2015a); ECHA (2018b) The ECHA registration dossier indicates the use of dipropylene glycol in dish wash and rinse products for commercial use. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are commercial based on inclusion in ECHA's uses by professional workers. Dry cleaning Commercial CPCat (2019) CPCat lists the use of dipropylene glycol in washing and dry cleaning of textile and fur products. Expected users are not listed but are expected to be commercial for dry cleaning. Fabric freshener Consumer DeLima Associates (2015h) CPID generally includes products for consumer use; therefore, the expected user is a consumer. Fabric softener Consumer DeLima Associates (2015e) CPID generally includes products for consumer use; therefore, the expected user is a consumer. XII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Laundry detergent Consumer, commercial DeLima Associates (2015i); ECHA (2018b) The ECHA registration dossier indicates the use of dipropylene glycol in laundry products including laundry detergents and laundry aids for commercial use. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are commercial based on inclusion in ECHA's uses by professional workers. Laundry detergent scent additive Consumer DeLima Associates (2016b) CPID generally includes products for consumer use; therefore, the expected user is a consumer. Prewash stain remover Consumer, commercial DeLima Associates (2014e); ECHA (2018b) The ECHA registration dossier indicates the use of dipropylene glycol in pre-spotter/ stain remover. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are commercial based on inclusion in ECHA's uses by professional workers. TSCA Conditions of Use: Manufacturing Synapse Information Resources (Synapse Information Resources (2009)) lists the use of dipropylene glycol in polyester and alkyd resins, reinforced plastics, plasticizers, solvents and fragrance, which are used in the manufacturing sectors listed below. Automotive manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the manufacture of motor vehicles, trailers, and semi-trailers, and other transport equipment. Expected users are industrial based on CPCat's user classification. Basic metal manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the manufacture of basic metals. Expected users are industrial based on CPCat's user classification. XIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Building material manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of "builders' carpentry and joinery." Expected users are industrial based on CPCat's user classification. EPA (2017b); CPCat (2019); ECHA (2018b) Chemical manufacturing Industrial CDR reports show use of dipropylene glycol as an intermediate and solvent (incorporated into the formulation, mixture, or reaction product) in the manufacture of basic organic chemicals and other chemical products and preparations. CPCat lists the use of dipropylene glycol in the manufacture of chemicals and chemical products. The ECHA registration dossier indicates the use of dipropylene glycol in the manufacture of fine chemicals. Expected users are industrial based on CDR's Industrial Processing and Use report. Communication equipment manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the "manufacture of radio, television, and communication equipment." Expected users are industrial based on CPCat's user classification. CPCat (2019) Computer and electronic manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of computer, electronic, optical products, and in electrical equipment, machinery and components (including valves, tubes, electronic boards, etc.). Expected users are industrial based on CPCat's user classification. Fabricated metal products manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the manufacture of "fabricated metal products, except machinery." Expected users are industrial based on CPCat's user classification. XIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Food manufacturing1 Industrial CPCat lists the use of dipropylene glycol in the manufacture of food products and beverages, and other food services. Expected users are industrial based on CPCat's user classification. CPCat (2019); ECHA (2018b) Furniture manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of furniture, including "office and shop furniture." The ECHA registration dossier indicates that dipropylene glycol has been used in the manufacture of furniture. Expected users are industrial based on CPCat's user classification. CPCat (2019) Iron metal manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of iron and metal products. Expected users are industrial based on CPCat's user classification. CPCat (2019); ECHA (2018b) Leather product manufacturing Consumer, commercial, industrial CPCat lists the use of dipropylene glycol in the manufacture of leather, leather apparel, bags, footwear and related products, including use in leather tanneries and as an impregnation material. The ECHA registration dossier indicates that dipropylene glycol has been used in leather treatment product. Expected users are industrial based on CPCat's user classification, and consumer/ commercial due to inclusion in ECHA's consumer uses and uses by professional workers. CPCat (2019) Metals manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of steel tubes, and structural metal products, including as cooling agent for metal processing. CPCat also lists use in treatment and coating of metals. Expected users are industrial based on CPCat's user classification. XV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Non-metallic mineral product manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the manufacture of non-metallic mineral products. Expected users are industrial based on CPCat's user classification. EPA (2017b); CPCat (2019) Paint manufacturing Industrial CDR reports show use of dipropylene glycol as a solvent and general paint/coating additive added during paint and coating manufacturing. CPCat lists the use of dipropylene glycol in the "manufacture of paints, varnishes, and similar coatings, print." Expected users are industrial based on inclusion in CDR's Industrial Processing and Use report. EPA (2017b); CPCat (2019); ECHA (2018b) Paper manufacturing Industrial CDR reports show use of dipropylene glycol as a pigment and dye in paper manufacturing. CPCat lists the use of dipropylene glycol in the manufacture of paper, pulp, paper products and paperboard, including use as a surface treatment for paper, and cardboard and impregnation materials for paper. The ECHA registration dossier indicates the use of dipropylene glycol, including as a solvent, in the manufacture of pulp, paper and paper products. Expected users are industrial based on inclusion in CDR's Industrial Processing and Use report. CPCat (2019) Perfume manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of perfumes. Expected users are industrial based on CPCat's user classification. EPA (2017b); CPCat (2019) Petrochemical manufacturing Industrial CDR reports show use of dipropylene glycol as an intermediate and process regulator in petrochemical manufacturing. CDR also reports use as a processing aid in the manufacture of carbon black. CPCat lists the use of dipropylene glycol in the manufacture of petrochemical manufacturing. Expected users are industrial based on CDR's Industrial Processing and Use report. XVI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References EPA (2017b); Dow (2009); CPCat (2019) Plastic and rubber manufacturing Industrial CDR reports show use of dipropylene glycol as a solvent in rubber product manufacturing and as an accelerator and intermediate in the manufacture of plastic products, material and resin. Dow identifies use of dipropylene glycol as a high- volume plasticizer, reactant in unsaturated polyurethane resins, initiator in urethane polyols, and reactive diluent in radiation- cured resins and coatings. CPCat lists the use of dipropylene glycol in the manufacture of plastics, rubber, plastic packing goods, plastics materials and resins, with functions including as an intermediate, hardener, and softener. Expected users are industrial based on CPCat's user classification. CPCat (2019) Soap manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of soaps and detergents, cleaning compounds, and cleaning and polishing. Expected users are industrial based on CPCat's user classification. EPA (2017b); CPCat (2019); ECHA (2018b) Textiles, apparel, and leather manufacturing Consumer, commercial, industrial CDR reports show use of dipropylene glycol as a finishing agent in textile, apparel, and leather manufacturing. CPCat lists the use of dipropylene glycol in the manufacture of textiles, including finishing of textiles, textile impregnation agents, and in upholstery of chairs and seats. The ECHA registration dossier indicates the use of dipropylene glycol in consumer textile dyes and impregnating products, manufacturing and industrial use of textile dyes and finishing products. Expected users are industrial based on CDR's Industrial Processing and Use report, and consumer/ commercial based on inclusion in ECHA's consumer uses and uses by professional workers. Transportation equipment manufacturing Industrial EPA (2017b) CDR reports show use of dipropylene glycol as a functional fluid in closed systems for transportation equipment manufacturing. Expected users are industrial based on CDR's Industrial Processing and Use report. XVII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Windmill manufacturing Industrial CPCat lists the use of dipropylene glycol in the "manufacture of windmills and parts of windmills." Expected users are industrial based on CPCat's user classification. CPCat (2019) Wood manufacturing Industrial CPCat lists the use of dipropylene glycol in the "manufacture of wood and products, of wood and cork" and wood building material including for the impregnation of wood, sawmilling, and wood preserving agents. Expected users are industrial based on CPCat's user classification. TSCA Conditions of Use: Pesticides and Agriculture CPCat (2019) Crop and animal production2 Industrial CPCat lists the use of dipropylene glycol in "crop and animal production, hunting and related service activities," including in the growing of perennial and non-perennial crops. Other uses in agricultural, including pesticides are listed elsewhere. Expected users are industrial based on CPCat's user classification. ECHA (2018b) Fertilizers Consumer, commercial The ECHA registration dossier indicates the use of dipropylene glycol in fertilizers and plant protection products. Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. XVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References | TSCA Conditions of Use: Miscellaneous CPCat (2019); ECHA (2018b) Absorbents and adsorbents Consumer CPCat lists the use of dipropylene glycol in adsorbents and adsorbents. No further information could be found on this use. The ECHA registration dossier indicates the use of dipropylene glycol in adsorbents. Expected users are consumer based on inclusion in ECHA's consumer. CPCat (2019); ECHA (2018b) Adhesives Consumer, commercial CPCat lists the use of dipropylene glycol in adhesives, binding agents, and glues, including in paints. The ECHA registration dossier indicates that dipropylene glycol is used in adhesives and sealants. Expected users are consumer and commercial due to inclusion in ECHA's consumer uses and uses by professional workers. EPA (2017b) Agricultural products Commercial, industrial CDR reports show use of liquid dipropylene glycol in commercial and industrial non-pesticide agricultural chemicals. CDR identifies concentrations of less than one percent by weight in commercial agricultural products. Expected users are commercial based on CDR's consumer/commercial classification and industrial based on CDR's Industrial Processing and Use report. CPCat (2019) Anti-foaming agent Unknown CPCat lists the use of dipropylene glycol in anti-foaming agent, foam-reducing agents. Expected users are unknown, due to the limited availability of information. EPA (2017b); GoodGuide (2011a); CPCat (2019); ECHA (2018b) Anti-freeze and de-icing products Consumer, commercial CDR reports show use of liquid dipropylene glycol in anti-freeze and de-icing products. Pollution Scorecard identifies use in consumer de-icing agents. CPCat lists the use of dipropylene glycol in anti-freeze and de-icing products. The ECHA registration dossier indicates the use of dipropylene glycol in anti-freeze and deicing products. Expected users are consumer and commercial based on CDR's consumer/commercial classification. XIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References EPA (2017b) Building/construction materials Commercial, industrial CDR reports show use of liquid dipropylene glycol in commercial building and construction materials not covered elsewhere, at concentrations of less than one percent by weight. CDR also reports use as a catalyst in industrial construction applications. Expected users are commercial based on CDR's consumer/commercial classification and industrial based on CDR's Industrial Processing and Use report. CPCat (2019) Casting and molding Consumer CPCat lists the use of dipropylene glycol as a casting agent in casting materials and molding compounds. Expected users are consumer. ECHA (2018b) Finger paints Consumer, commercial The ECHA registration dossier indicates the use of dipropylene in finger paints. Uses in other paints is listed elsewhere. This product is likely to be used by children. Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. EPA (2017b) Golf and sports turf Commercial CDR reports show use of liquid dipropylene glycol in golf and sports turf at concentrations of at least 90 percent by weight. Expected users are commercial based on CDR's consumer/commercial classification. ECHA (2018b) Hydraulic fluids Consumer, commercial The ECHA registration dossier indicates the use of dipropylene glycol in hydraulic fluids. Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. XX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References EPA (2017b); CPCat (2019); Synapse Information Resources (2009); ECHA (2018b) Ink and toner Consumer, commercial, industrial CDR reports show use of liquid dipropylene glycol in ink, toner, and colorant products. CDR identifies concentrations (by weight) of at least one percent but less than 30 percent and at least 60 percent but less than 90 percent in reported products. CDR also reports use as a solvent in the manufacture of printing ink. CPCat lists the use of dipropylene glycol in print, inks, colorants, and toners. Synapse Information Resources lists the use of dipropylene glycol in printing inks. The ECHA registration dossier indicates the use of dipropylene glycol in ink ands and toners for consumer, commercial and industrial use. Expected users are consumer and commercial based on CDR's consumer/commercial classification and industrial based on CDR's Industrial Processing and Use report. EPA (2017b); ECHA (2018b) Intermediates Commercial, industrial CDR reports show use of liquid dipropylene glycol in urethane intermediates at concentrations of at least 90 percent by weight. The ECHA registration dossier indicates the use of dipropylene glycol as an intermediate at industrial sites, there is no further information on current use as an intermediate for industrial users in the United States. Expected users are commercial based on CDR's consumer/commercial classification, and industrial based on inclusion in ECHA's uses at industrial sites. EPA (2017b); Dow (2009); CPCat (2019); ECHA (2018b) Lubricants and greases Consumer, commercial, industrial CDR reports show use of liquid dipropylene glycol in commercial lubricants and greases at concentrations of less than one percent by weight. CDR also reports use as a lubricant and lubricant additive in industrial non-oil and gas mining and support activities. Dow identifies use of dipropylene glycol in cutting oils (often used in metalworking applications). CPCat lists the use of dipropylene glycol in lubricants and greases. The ECHA registration dossier indicates the use of dipropylene glycol in lubricants, greases and release products for consumer and industrial use. Expected users are commercial based on CDR's consumer/commercial classification and industrial based on CDR's Industrial Processing and Use report, and consumer based on inclusion in ECHA's consumer uses. XXI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References EPA (2017b); GoodGuide (2011a); CPCat (2019); Synapse Information Resources (2009); ECHA (2018b) Paints and coatings Consumer, commercial CDR reports show use of liquid dipropylene glycol in paints and coatings at concentrations of at least one percent but less than 30 percent by weight. Pollution Scorecard identifies use in paints and primers for vehicles and machinery refinish as well as interior water-thinned coatings. CPCat lists the use of dipropylene glycol in paint, lacquers, varnish, and primers, including for decorative, protective, interior and exterior use. Synapse Information Resources lists the use of dipropylene glycol in lacquer, paints and shellac varnishes. The ECHA registration dossier indicates the use of dipropylene glycol in coatings, paints, and thinners. Expected users are consumer and commercial based on CDR's consumer/commercial classification. CPCat (2019); ECHA (2018b) Paint and varnish remover Consumer CPCat lists the use of dipropylene glycol as a solvent in paint and varnish removers. The ECHA registration dossier indicates the use of dipropylene glycol in paint removers. Expected users are consumer based on inclusion in ECHA's consumer uses. EPA (2017b); ECHA (2018b) Paper products Consumer, commercial CDR reports show use of liquid dipropylene glycol in commercial paper products at concentrations of less than one percent by weight. The ECHA registration dossier indicates that dipropylene glycol has been used in paper and board treatment products. Expected users are commercial based on CDR's consumer/commercial classification, and consumer based on ECHA's consumer uses. CPCat (2019) Pet litter Consumer CPCat lists the use of dipropylene glycol in pet litter available for retail use. Expected users are consumer based on CPCat's user classification. XXII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019); ECHA (2018b) Photographic Consumer CPCat lists the use dipropylene glycol in reprographic agents and photo-chemicals. The ECHA registration dossier indicates the use of dipropylene glycol in photo-chemicals. Expected users are consumer based on inclusion in ECHA's consumer uses. EPA (2017b); CPCat (2019) Plastic and rubber products Commercial CDR reports show use of liquid, pellet, and large crystal dipropylene glycol in commercial plastic and rubber products not covered elsewhere at concentrations of at least one percent but less than 60 percent by weight. CPCat lists the use of dipropylene glycol in plastic and rubber products. Expected users are commercial based on CDR's consumer/commercial classification. CPCat (2019); ECHA (2018b) Polishing agents Consumer, commercial CPCat lists the use dipropylene glycol in polishing agents. The ECHA registration dossier indicates the use of dipropylene glycol in polishes and wax blends Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. GoodGuide (2011a) Sealants Consumer Pollution Scorecard identifies use of dipropylene glycol in nonstructural caulking compounds and sealants. Expected users are consumer based on inclusion in GoodGuide's consumer uses. CPCat (2019) Toys Consumer CPCat lists the use of dipropylene glycol in consumer toys, listed for child use, including fragrances and pool supplies. Expected users are consumer based on CPCat's user classification. XXIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019); ECHA (2018b) Water treatments Consumer, commercial, industrial CPCat lists the use of dipropylene glycol in water treatment including softeners and lime deposit (calcium) remover. The ECHA registration dossier indicates the use of dipropylene glycol in water treatment chemicals. Expected users are based on inclusion in ECHA's consumer uses, uses by professional workers, and uses at industrial sites. CPCat (2019); ECHA (2018b) Welding and soldering Consumer CPCat lists the use of dipropylene glycol in welding and soldering agents, including soldering paste. The ECHA registration dossier indicates the use of dipropylene glycol in welding and soldering products. Expected users are consumer based on inclusion in ECHA's consumer uses. ECHA (2018b) Whiteboard marker Consumer The ECHA registration dossier indicates the use of dipropylene glycol in whiteboard markers. Expected users are consumer based on inclusion in ECHA's consumer uses. Non-TSCA Uses CPCat (2019) Additive Unknown CPCat lists the use of dipropylene glycol in food additives, including in salt, spices and seasonings. Expected users are unknown, due to the limited availability of information. Animal insecticide Consumer DeLima Associates (2014a) CPID generally includes products for consumer use; therefore, the expected user is a consumer. XXIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Antiperspirant Consumer DeLima Associates (2013b); GoodGuide (2011a); CPCat (2019) GoodGuide identifies use of dipropylene glycol in deodorants. CPCat lists the use of dipropylene glycol in deodorants and antiperspirants. Expected users are consumer based on inclusion in CPID and GoodGuide's consumer uses. Bactericides Unknown CPCat (2019) CPCat lists the use of dipropylene glycol in bactericides which function to kill bacteria, and bacteriostats, which function to stop bacteria from reproducing. Expected users are unknown, due to the limited availability of information. Bath accessories Consumer CPCat (2019) CPCat lists the use of dipropylene glycol in bath accessories for personal use and in bath products meant for use by babies. Expected users are not listed but expected to be consumer for personal care bath accessories. Body cleanser Consumer CPCat (2019) CPCat lists the use of dipropylene glycol in body cleansers. Expected users are not listed but expected to be consumer for body cleansers. Body oil Consumer DeLima Associates (2011a); CPID generally includes products for consumer use; therefore, the expected user is a consumer. Body wash Consumer DeLima Associates (20151) CPID generally includes products for consumer use; therefore, the expected user is a consumer. XXV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References Cuticle treatment DeLima Associates (2011a) Consumer CPID generally includes products for consumer use; therefore, the expected user is a consumer. CPCat (2019) Disinfectants Unknown CPCat lists the use of dipropylene glycol in disinfecting agents and other sanitation agents. Expected users are unknown, due to the limited availability of information. Drugbank (2018a) Facial masks Consumer, commercial DrugBank lists the use of liquid dipropylene glycol in topical facial masks listed as currently available for over-the-counter use in the United States. Expected users are consumer and commercial, as the products is available for over-the-counter purchase. First aid spray Consumer DeLima Associates (2014b) CPID generally includes products for consumer use; therefore, the expected user is a consumer. CPCat (2019); Descartes Datamyne (2018); ECHA (2018b) Fragrance Consumer CPCat lists the use of dipropylene glycol as an odor agent in fragrances for cosmetic and personal care use. Datamyne reports the export of "dipropylene glycol fragrance" from the U.S. to foreign countries. The specific products or use of the exported fragrance is unknown. The ECHA registration dossier indicates the use of dipropylene glycol in perfumes and fragrances. Expected users are consumer based on inclusion in ECHA's consumer uses. Hair conditioner Consumer DeLima Associates (2016c) CPID generally includes products for consumer use; therefore, the expected user is a consumer. XXVI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Hair dye Consumer CPCat lists the use of dipropylene glycol in hair dye colorants. Expected users are not listed but expected to be consumer for hair dyes. DeLima Associates (2016a); P&G (2015) Hair shampoo Consumer, commercial Dipropylene glycol is listed as an ingredient in a hair shampoo product intended for professional use. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Expected users are commercial as the product is listed for professional use. Hair straightener Consumer DeLima Associates (2011b) CPID generally includes products for consumer use; therefore, the expected user is a consumer. DeLima Associates (2013b); CPCat (2019) Hair styling Consumer CPCat lists the use of dipropylene glycol in hair styling products. CPID generally includes products for consumer use; therefore, the expected user is a consumer. Hair toner Consumer DeLima Associates (2017b) CPID generally includes products for consumer use; therefore, the expected user is a consumer. CPCat (2019) Hand cream and lotion Consumer CPCat lists the use of dipropylene glycol in hand creams and lotions. Expected users are not listed but expected to be consumer for hands creams and lotions. XXVII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Hand sanitizers Consumer CPCat lists the use of dipropylene glycol in hand sanitizers. Expected users are not listed but expected to be consumer for hand sanitizers. CPCat (2019) In-can preservatives Unknown CPCat lists the use of dipropylene glycol in in-can food preservatives. Expected users are unknown, due to the limited availability of information. CPCat (2019); ECHA (2018b) Insecticide Consumer, commercial CPCat lists the use of dipropylene glycol in insecticides which function specifically to kill insects. The ECHA registration dossier indicates the use of dipropylene glycol in insecticides, repellents and other biocidal products. Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. ECHA (2018b) Medical devices Commercial The ECHA registration dossier indicates the use of dipropylene glycol in professional medical devices, Expected users are commercial based on inclusion in ECHA's uses by professional workers. California Deptof Pesticide Regulation (2018); NPIRS (2018); GoodGuide (2011a); CPCat (2019); ECHA (2018b) Pesticides Commercial, industrial The California Department of Pesticide Regulation (Cal DPR) identifies four companies that use dipropylene glycol as an active ingredient in pesticides. Cal DPR also reports 14 companies that use dipropylene glycol as an inactive ingredient in pesticides. NPIRS identifies two companies that use dipropylene glycol in federally active pesticides. Pollution Scorecard identifies use of dipropylene glycol in deodorizing and sanitizing pesticides. CPCat lists the use of dipropylene glycol in non- agricultural and agricultural pesticides, including as an inert or active ingredient, antimicrobial, and some listings indicating use in food. The ECHA registration dossier indicates the use of dipropylene glycol in biocidal products. Expected users are consumer due to inclusion in ECHA's consumer uses, and industrial due to its use in pesticide manufacturing. XXVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References ECHA (2018b) Pharmaceutical uses Consumer, commercial The ECHA registration dossier indicates the use of dipropylene glycol in pharmaceuticals. Expected users are consumer and commercial based on inclusion in ECHA's consumer uses and uses by professional workers. CPCat (2019) Razors Consumer CPCat lists the use of dipropylene glycol in razors as tools for hair removal. Expected users are not listed but expected to be consumer for razors. Shampoo manufacturing Industrial CPCat (2019) CPCat lists the use of dipropylene glycol in the manufacture of hair shampoo. Expected users are industrial based on CPCat's user classification. CPCat (2019) Shaving cream Consumer CPCat lists the use of dipropylene glycol in shaving cream. Expected users are not listed but expected to be consumer for shaving cream. CPCat (2019) Skin cleanser Consumer CPCat lists the use of dipropylene glycol in skin cleansers which broadly includes person care soaps, shower gels, and hand cleansing creams. Expected users are not listed but expected to be consumer for skin cleansers. XXIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table A.3: Uses of Dipropylene Glycol Use Expected Users Description of Use and References CPCat (2019) Toothpaste manufacturing Industrial CPCat lists the use of dipropylene glycol in the manufacture of toothpaste. Expected users are industrial based on CPCat's user classification. Children's Products CDR reports show use of liquid dipropylene glycol in consumer and commercial children's personal care products; further sources report use of dipropylene glycol in body wash, toys, and finger paints intended for use by children. Recycling and Disposal I In the 2016 CDR, one facility, Proviron Inc., reported that dipropylene glycol was recycled (recycled, remanufactured, reprocessed, or reused). Thirty-eight facilities reported that the chemical was not recycled, while ten facilities withheld this information and seven facilities reported this information as CBI (EPA 2017b). I Note(s): 1. TSCA product based on the assumption that the chemical is used in the manufacturing of products and not intended to be a component of food. 2. Assumed to be a mix of TSCA and non-TSCA products. It is expected that more specifically defined uses in the table are representative of the uses that fall into this category. XXX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** A.3 References Boscia. (2018). Sake Hydrating and Brightening Serum. Retrieved from https://www.boscia.com/shop/product detail.php?products id=278 California Dept of Pesticide Regulation. (2013). DPR Databases. Retrieved from https://www.cdpr.ca.gov/dprdatabase.htm California Dept of Pesticide Regulation. (2018). DIPROPYLENE GLYCOL. Retrieved from https://apps.cdpr.ca.gov/cgi-bin/label/comp.pl Cetaphil. (2018). Baby Daily Lotion. Retrieved from https://www.cetaphil .com/babv-1 otion/ CVS. (2018). Beauty 360 Pear And White Tea Anti-Bacterial Foaming Hand Soap, 7.5 OZ. Retrieved from https://www.cvs.com/shop/beaiitv-36Q-pear-and-white-tea-anti-bacterial-foaming-hand- soap-7~5~oz~prodid~ .1.02045 7 Danish EPA. (2018). Danish surveys on chemicals in consumer products. Retrieved from https://eng.mst.dk/chemicals/chemicals-in-products/consumers-consumer-products/danish- survevs-on-consumer-products/ DeLima Associates. (2008a). Pledge Commercial Line, Lemon Clean, Aerosol, Professional Use- 08/22/2008. Retrieved from Pledge Commercial Line, Lemon Clean, Aerosol, Professional Use- 08/22/2008 DeLima Associates. (201 la). Avon Skin So Soft Original Gelled Body Oil. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1 /11175/standard/Avon%20Skin%20So%20 Soft%200riginal%20Gelled%20Bodv%200il/0.1. -022-1.05 DeLima Associates. (201 lb). Joico K-Pak Style Smoothing Hair Balm. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/ 1/standard/Joico%20K- Pak%20Stvle%20Smoothing%20Hair%20Balm/l 0-0.1.3-003 DeLima Associates. (2013a). Air Wick Air Freshener with 100 Percent Natural Propellant, Vanilla Indulgence. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1/16298/standard/p%20class=%22p 1 %22%3 EAir%20Wick%20Air%20Freshener%20with%20100%20Percent%20Natural%20Propellant.%2 0Vanilla%20Indulgence.%20Aerosol-07/l8/2013/p?o 'i I y-001-977 DeLima Associates. (2013b). AXE Natural Look Hair Cream With Tea Tree Extract. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/13431/standard/AXE%20Natnral%20Look %20Hair%20Cream%20With%20Tea%20Tree%20Exto 309 DeLima Associates. (2013c). Nilodor Natural Touch Paw TRAX Foaming Cleaner for Carpet & Upholstery-06/27/2013. Retrieved from xxxT ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** https://www.whatsinproclucts.com/tvpes/tvpe detail/1 I > ?%/standard/p%3ENilodor%20Natural -06/27/2013/p%3E/14-013-053 DeLima Associates. (2014a). Absorbine Flys-X Ready to Use Insecticide Spray. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/14264/standard/Absorbine%20Flvs- 41014)01 DeLima Associates. (2014b). Lanacane First Aid Spray, Aerosol-12/29/2014. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/1/16327/standard/p%20class=%22pl%22%3 Espan%20class=%22sl%22%3ELanacane%20First%20Aid%20Sprav.%20 Aerosol- 12/29/2014/span%3E/p%'t IS 030-010 DeLima Associates. (2014c). Mop & Glo Professional Multi-Surface Floor Cleaner, Professional Use- 10/09/2014. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/ 1/standard/p%20class=%22p.1.%22%3 EMop%20&%20Glo%20Professional%20Multi- Surface%20Floor%20Cleaner.%20Professional%20Use-l 0/09/2014/p%-U-' IK -001-793 DeLima Associates. (2014e). Resolve Max Power Laundry Pre-Treater Gel-11/26/2014. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/16019/standard/p%20class=%22pl%22%3 EResolve%20Max%20Power%20Laundrv%20Pre-Treater%20Gel-l 1/26/2014/p%3E/1.8-001- 705 DeLima Associates. (2015a). Cascade Actionpacs Dishwasher Detergent, Citrus Scent. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1/17825/standard/p%20class=%22pl%22%3 ECascade%20Actionpacs%20Dishwasher%20Detergent%20Citrus%20Scent- 03/30/201.5/p 3-182 DeLima Associates. (2015b). Cascade Dishwasher Cleaner, Fresh Scent. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1 /17832/standard/p%20class=%22p 1 %22%3 ECascade%20Dishwasher%20Cleaner.%20Fresh%20Scent-03/26/2015/p%: 33-1.89 DeLima Associates. (2015c). Clorox Automatic Toilet Bowl Cleaner Bleach & Blue, Rain Clean. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/16398/standard/p%3EClorox%20Automati c%20Toilet%20Bowl%20Cleaner%20Bleach%20&%20Blue.%20Rain%20Clean- 01/05/2015/p%3E/03-027-349 DeLima Associates. (2015d). Clorox Commercial Solutions Clorox 4 in One Disinfectant and Sanitizer. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/16487/standard/p%3EClorox%20Commer cial%20Solutions%20Clorox%204%20in%20Qne%20Disinfectant%20and%20Sanitizer,%20Aer osol.%20Professional%20Use-01/05/2015/p%3E/03-027-432 ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** DeLima Associates. (2015e). Downy Ultra Infusions Fabric Softener, Amber Blossom. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/ 1/standard/p%20class=%22p 1 %22%3 EDownv%20Ultra%20Infiisions%20Fabric%20Softener.%20Amber%20Blossom- 03/03/2015/p 0-954 DeLima Associates. (2015f). Drano Max Build Up Remover, Commercial Line, Professional Use- 04/02/2015. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/1/1654l/standard/p%20class=%22pl%22%3 Espan.%20class=%22s.l.%22%3EDran.o%20Max%20Build%20Up%20Remover.%20Commercial %20Line,%20ProfessionaI%20Use- DeLima Associates. (2015g). Febreze Candle Hawaiian Aloha. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1/18034/standard/p%2 EFebreze%20Candle%20Hawaiian%20Aloha-03/24/201 5/d( 5-394 DeLima Associates. (2015h). Febreze Fabric Refresher, Free. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1/18050/standard/p%20class=%22pl%22%3 EFebreze%20Fabric%20Refresher.%20Free.%20Pump%20Sprav-02/23/2015/p 3-409 DeLima Associates. (2015i). Gain Ultra Laundry Detergent Powder, Original-04/17/2015. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/ ^/standard/p%20class=%22p.1.%22%3 EGain%20Ultra%20Laundrv%20Detergent%20Powder.%20Qriginal -04/ .1.7/2015/p' h 944 DeLima Associates. (2015j). Method Daily Granite, Cleans + Polishes, Apple Orchard. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/19396/standard/p%3EMethod%20Dailv%2 QGranite.,%20Cleans%20+%20Polishes.%20Apple%200rchard.%20Pump%20Sprav- 05/11/2015/p 6-1.30 DeLima Associates. (2015k). Method Daily Shower, Eucalyptus Mint, Pump Spray-05/11/2015. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/19398/standard/p%3EMethod%20Dailv%2 0Shower..%20Eucalvptus%20Mint.%20Pump%20Sprav-05/l l/2015/p% )36-132 DeLima Associates. (20151). Old Spice Dry Skin Defense Body Wash, Live Wire-02/18/2015. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/ S/standard/p%20class=%22p.1.%22%3 E01d%20Spice%20Drv%20Skin%20Defense%20Bodv%20Wash.%20Live%20Wire- 02/ .1.8/2015/p 0-827 DeLima Associates. (2015m). Pledge FloorCare Multi-Surface Finish-02/25/2015. Retrieved from https://www.whatsinproducts.com/tvpes/type detail/l/16567/standard/p%20class=%22pl%22%3 EPledge%20FloorCare%20Multi-Surface%20Finish-02/25/20.1.5/p%3E/.1.9-(HJ I XXXiii ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** DeLima Associates. (2015n). Scrubbing Bubbles Bathroom Cleaner with Color Power Technology, Aerosol-02/24/2015. Retrieved from https://www.whatsinproclucts.com/tvpes/tYpe detail/1 /1660l/standard/p%20class=%22p 1 %22%3 ig%20Bubbles%20Bathroom%20Cleaner%20with%20Color%20Power%20Technolog v.%20Aerosol-02/24/20 15/p° DeLima Associates. (2015o). Windex Crystal Rain, Pump Spray-02/25/2015. Retrieved from https://www.whatsinproducts.com/types/tvpe detail/l/16609/standard/p%20class=%22pl%22%3 EWindex%20Crvstal%20Rain.%20Pump%20Sprav-02/25/2015/p% >01-629 DeLima Associates. (2016a). Dove Advanced Hair Series Regenerative Nourishment Shampoo with Red Algae Complex-04/27/2016. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/Li° I S0/standard/p%3EDove%20Advanced %20Hair%20Series%20Regenerative%20Nourishment%20Shampoo%20with%20Red%20Algae %20Complex-04/27/2016/p%3E/2.1. -0.1.0-423 DeLima Associates. (2016b). Febreze, Unstopables, In-Wash Scent Booster, Dreams-01/21/2016. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/1/18369/standard/p%20class=%22pl%22%3 EFebreze.%20Unstopables.%20In-Wash%20Scent%20Booster.%20Dreams- 01/21/201.6/p 3-488 DeLima Associates. (2016c). Herbal Essences, Bio Renew, Sheer Moisture Conditioner, Cucumber & Green Tea-08/11/2016. Retrieved from https://www.whatsinproducts.com/tvpes/type detail/1/21652/standard/p%20class=%22p 1 %22%3 EHerbal%20Essences.%20Bio%20Renew.%20Sheer%20Moisture%20Conditioner.%20Cucumbe r%20&%20Green%20Tea-08 1 I ..>016/p%3E/16-033-569 DeLima Associates. (2017a). Carbona Stain Devils No. 2, Chocolate, Ketchup & Mustard. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/19466/standard/p%20class=%22pl%22%3 ECarbona%20Stain%20Devils%20No.%202.%20Chocolate.%20Ketchup%20&%20Mustard- 02/10/201.7/p%3E/04-030-006 DeLima Associates. (2017b). Dove Advanced Hair Series, Quench Absolute Intense Restoration Mask for Curly, Coarse Hair. Retrieved from https://www.whatsinproducts.com/tvpes/tvpe detail/l/19210/standard/p%3EDove%20Advanced %20Hair%20Series.%20Quench%20Absolute%20Intense%20Restoration%20Mask%20for%20C urlv.%20Coarse%20Hair-05/.1.0/201'/»>"; 1 'a DeLima Associates. (2018). Consumer Product Information Database. Retrieved from https://www.whatsinproducts.com/ Descartes Datamyne. (2018). Descartes Datamyne Import-Export Database. XXXIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Dionisio, K. L (CPCat)., Frame, A. M., Goldsmith, M.-R., Wambaugh, J. F., Liddell, A., Cathey, T., . . . Judson, R. S. (2015). Exploring consumer exposure pathways and patterns of use for chemicals in the environment. Toxicology Reports, 2, 228-237. doi:http://dx.doi.org/10 101o/i.toxrep.2014..1.2.009 Dove. (2018). Nutritive Solutions Intensive Repair Conditioner. Retrieved from https://www.dove.com/za/liair-care/conditioner/nutritive-soliitions-intensive-repair- conditioner.html Drugbank. (2018a). Dipropylene glycol. Retrieved from https://www.drugbank.ca/drugs/D DrugBank. (2018b). DrugBank Database. Retrieved from https ://www. dru gbank. ca/ European Chemicals Agency (ECHA). (2018a). l,l'-oxydipropan-2-ol. Retrieved from https://eeha.eiiropa.eii/siibstanee-infi3 rTOation./~/siibstaneeinfo/.l. 00.003.475 European Chemicals Agency (ECHA). (2018b). Oxydipropanol. Retrieved from https://echa.europa.eii/registration-dossier/-/registered-dossier/ .1.601.6/1 EWG. (2018a). Dipropylene Glycol. Retrieved from https://www.ewg.org/skindeep/ingredient/702123/DIPROPYLENE GLYCOL/ EWG. (2018b). Skin Deep Cosmetics Database. Retrieved from https://www.ewg.Org/skindeep/#.W4RpIPlKiUk GoodGuide. (201 la). Dipropylene glycol. Retrieved from http://seoreeard.goodguide.eom/ehemieal- profiles/summarv.tcl?edf substance id=+25265-71-8#use profile GoodGuide. (201 lb). Scorecard: The Pollution Information Site. Retrieved from http://scorecard.goodgiiide.com/chemical-profiles/index.tcl Government of Canada. (2018). Chemical Substances: Services and Information. Retrieved from https://www.canada.ca/en/liealth-canada/services/chemical-siibstances.html Kim, S., Thiessen, P. A., Bolton, E. E., Chen, J., Fu, G., Gindulyte, A., . . . Bryant, S. H. (2016). PubChem Substance and Compound databases. Nucleic Acids Research, 7-/(Database issue), D 1202-D 1213. doi: 10.1093/nar/gkv951 Kirk-Othmer. (2006). Kirk-Othmer Encyclopedia of Chemical Technology. Medline.com. (2009). Material Safety Data Sheet. Retrieved from https://www.medline.com/media/catalog/Docs/MSDS/MSD SD I8.pdf Code of Federal Regulations, Title 21 Food and Drugs, (2018). ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** National Pesticide Information Retrieval System (NPIRS). (2018). Company Information. Retrieved from http://npirspublic.ceris.purdue.edii/ppis/chemical2.aspx Organisation for Economic Cooperation and Development (OECD). (2001). Dipropylene glycol, mixed isomers and dominant isomer. Retrieved from: http://www.inchem.org/documents/sids/sids/25265-71-8.pdf Organisation for Economic Cooperation and Development (OECD). (2018). eChemPortal: Global Portal to Information on Chemical Substances. Retrieved from g/echemportal/index.action P&G. (2015). Safety Data Sheet. Retrieved from Sherlock. Scott. (2019). Email [Non-CBI redactedl. 25265-71-8 FW TSCA Low Priority Chemical Review Processes CBI Review. July 9. Shiseido. (2018). Benefiance WrinkleResist24 Protective Hand Revitalizer. Retrieved from https://www.shiseido.com/benefiance-wrinkleresist24-protective-hand-revitalizer- 0730852118744.html Skinfood. (2018). 0.9 Moist Toner. Retrieved from ^ Lus/products/0-9-moist-toner Synapse Information Resources. (2009). Specialty Chemicals Source Book. Fourth Edition. Volume 1. The Dow Chemical Company. (2009). Dipropylene Glycol Regular Grade (DPG). Retrieved from https://web.archive.Org/web/20090714065203/littp://www.dow.com:80/propvleneglvcol/prod/dpg .htm U.S. Environmental Protection Agency (EPA). (2002). 1986-2002 Historical IUR Data. Retrieved from Excel File U.S. Environmental Protection Agency (EPA). (2006). 2006 IUR Public Database. U.S. Environmental Protection Agency (EPA). (2017a). Functional Use Database (FUse). Retrieved from: https://catalog.data.gov/dataset/fnnctional-iise-database-flise U.S. Environmental Protection Agency (EPA). (2017b). Non-Confidential 2016 Chemical Data Reporting (CDR). Retrieved from https://www.epa.gov/chemical-data-reporting U.S. Environmental Protection Agency (EPA). (2018a). ChemView. Retrieved from https://chemview.epa.gov/chemview U.S. Environmental Protection Agency (EPA). (2018b). Envirofacts Multisystem Search. Retrieved from https://www3.epa.gov/enviro/facts/multisvstem.html XXXVi ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** U.S. Environmental Protection Agency (EPA). (2018c). Look up table for BR Waste Code (National Biennial RCRA Hazardous Waste Report). Retrieved from https://iaspub.epa.gov/enviro/brs codes v2.waste lookup U.S. Environmental Protection Agency (EPA). (2018d). Safer Chemical Ingredients List. Retrieved from https://www.epa.gov/saferchoice/safer-ingredients U.S. Environmental Protection Agency (EPA). (2018e). TRI-Listed Chemicals. Retrieved from https://www.epa.gov/toxics-release-inventorv-tri-program/tri-listed-chemicals U.S. National Library of Medicine (NLM). (2018a). ChemlDplus, a TOXNET Database. Retrieved from https ://che m. nl m. nih. gov/che midplus/ U.S. National Library of Medicine (NLM). (2018b). Haz-Map. Retrieved from https://hazmap.nl m.nih.gov/categorv-details?id=5009&table=copvtblagents U.S. Patent and Trademark Office (USPTO). (2018a). Dipropylene glycol. Retrieved from http://patft.uspto.gov/netacgi/nph- Parser?Sectl=PT02&Sect2=HIT0FF&p=l&u=%2Fnetahtml%2FPT0%2Fsearch- bool.html&r=0&f=S&l=50&TERMl=Dipropvlene+glvcol&FIELDI=&cot=AND&TERM2=&F IELD2=&d=PTXT U.S. Patent and Trademark Office (USPTO). (2018b). USPTO Patent Full-Text and Image Database. Retrieved from http://patft.uspto.gov/netacgi/nph- Parser?S( fcSect2=HITOFF&p=l&u=%2Fnetahtml%2FPTO%2Fsearch- bool .htm l&t=0&f=S&l=5 O&TERM 1=1 %2C 1 %27-oxvdi-2- propanol &FIELD .1.=&co .1.=AND&TERM2=&FIELD2=&d=PTXT Ullmann's. (2000). ULLMANN'S Encyclopedia of Industrial Chemistry. Washington State Dept. of Ecology. (2018). Children's Safe Product Act Reported Data. Retrieved from https://fortress.wa.gov/ecv/cspareporting/ OCXVil ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Appendix B: Human Hazard Characterization Table B.1:t Human Health Hazard ADME Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940508, 4940301, 3039551 Dermal (in vitro) Human cadaver skin 24 hours Dose: 768 |iL undiluted test substance Replicates: 7 samples from 4 cadavers The test material was considered a slow penetrant Methods: Test substance reported as CASRN 25265-71 - 8 Purity: 99.9% OECD Guideline 428 GLP compliant Results: Steady state penetration was 39.3 pg/cm2- hour and the permeability coefficient was 3.85x10"5 cm/hour 3041958 Intravenous and oral Dog 24 hours Dose: 5000 mg/kg oral and 2000 mg/kg IV Replicates: 2 dogs The test material is no longer detectable in blood after 24 hours Methods: Test substance reported as CASRN 25265-71- 8 Purity not reported GLP compliance not reported 4940456, 4940388 Oral (gavage) Fischer 344 rats Single exposure, 24 hour observation Doses: 48.2 mg/kg Replicates: 5 male rats The test material is rapidly absorbed and distributed, and primarily excreted through urine. It is also extensively metabolized to dipropylene and monopropylene glycol and further oxidized to C02. Methods: Test substance reported as CASRN 24800-44- 0 Purity: 99.8% GLP compliant Results: Absorption: 91.4 ± 2.07 % of the dose administered was recovered indicating tripropylene glycol is rapidly absorbed Distribution: The liver and kidney had the greatest amounts of tripropylene glycol Metabolism: Tripropylene glycol is extensively metabolized. 5.8% of the dose was recovered XXXVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** as unmetabolized parent compound. Tripropylene glycol is metabolized to dipropylene and monopropylene glycol and further oxidized to CO2 Excretion: Dipropylene glycol was excreted primarily in the urine (52.3 ± 3.54%) and in exhaled breath (20.7±0.59%) Acute Mammalian Toxicity Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940443 Inhalation Sprague-Dawley 4 hours, observed for Dose: 2.34 LCso > 2.34 mg/L Methods: (aerosol) rats 14 days mg/L Replicates: 5 per sex Test substance reported as CASRN 25265-71 - 8 Purity: 100% EPA OPP 81-3 GLP compliant 4940457 Oral (gavage) Sprague-Dawley Single exposure, Dose: 5010 LD50 >5010 mg/kg Methods: rats observed for 14 days mg/kg Replicates: 5 per sex Test substance reported as CASRN 25265-71 - 8 Purity: 100% EPA OPP 81-1 GLP compliant Results: No mortality Decreased locomotor activity reported in 2/5 males, the remaining 3 males and 5 females were ataxic 4 males and 1 female had yellow perineal staining after 5 hours 4940464, Oral (gavage) Wister rats Single exposure, Doses: 8.6, LD5o:15.8 mL/kg (or Methods: 4940388 observed for 14 days 10.4, 12.4, 14.9, and 17.9 16,000 mg/kg) Test substance reported as CASRN 25265-71 - 8 ml/kg Replicates: 5 per sex per dose Purity: 100% Similar to OECD 401 (acute oral toxicity) Not GLP compliant Results: XXXIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 8.6 mL/kg: 0/5 males or females 10.4 mL/kg: 2/5 males and 0/5 females 12.4 mL/kg: 0/5 males or females 14.9 mL/kg: 2/5 males and females 17.9 mL/kg 4/5 males and females 4940453 Dermal New Zealand white rabbits 24 hour exposure, observed for 14 days Dose: 5010 mg/kg Replicates: 5 per sex LDso >5010 mg/kg Methods: Test substance: CASRN 25265-71-8 Purity: 100% EPA OPP 81-2 GLP compliant Repeated Dose Toxicity Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940384, 4940445 Oral (drinking water) B6C3F1 mice 2 years Doses: Males: 0, 735, 1220, 2390 mg/kg-day Females: 0, 575,1040, and 1950 mg/kg-day Replicates: 50 per sex per dose NOAEL: 1040 mg/kg- day LOAEL: 1950 mg/kg- day based on decreased mean body weight Methods: Test substance reported as CASRN 25265-71 - 8 Purity: 99% NTP Guideline GLP compliant 4940466, 4940384 Oral (drinking water) B6C3F1 mice 13 weeks Doses: Males: 0, 715, 1350, 2620, 4790 and 11,000 mg/kg- day Females: 0, 1230,2140, 4020, 7430 and 14700 mg/kg-day NOAEL: 2620 mg/kg- day (male) LOAEL: 4790 mg/kg- day (male), based on increased liver weight Methods: Test substance reported as CASRN 25265-71 - 8 Purity: 99% NTP guideline GLP compliant Results: Mortality 0 7,430 mg/kg-day females: (1/10) hypothermia XL ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Replicates: o 11,000 mg/kg-day males: (3/10) 10 per sex per dehydration dose o 14,700 mg/kg-day females: (1/10) dehydration 4940384, Oral (drinking F344/N rats 2 years Doses: NOAEL: 115 mg/kg- Methods: 4940465, water) Males: 0,115, day Test substance: CASRN 25265-71-8 4940455 470, and 3040 mg/kg-day Females: 0, 140, 530, and 2330 mg/kg- day Replicates: 50 per sex per dose LOAEL: 470 mg/kg- day based on increased incidence of nephropathy, focal histiocytic, and focal granulomatous inflammation in male livers Purity: 99% GLP compliance not reported 4940384, Oral (drinking F344/N rats 14 weeks (3 months) Doses: NOAEL: 425 mg/kg- Methods: 4940462 water) Males: 0, 425, 890, 1840, 3890, and 12,800 mg/kg- day Females: 0, 460, 920, 1690, 3340, and 8950 mg/kg-day Replicates: 10 per sex per dose day LOAEL: 890 mg/kg- day based on relative liver weight Test substance reported as CASRN 25265-71 - 8 Purity: 99% GLP compliance not reported Reproductive Toxicity Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940389, Oral (gavage) Sprague-Dawley Male: 2 weeks prior to Doses: 0, 8, NOAEL: 1000 mg/kg- Method: 4940514 rats mating, 49 days total 40, 200, and 1000 mg/kg- day day Test substance reported as CASRN 24800- 44-0 XLI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Females: 2 weeks prior to mating up to day 3 of lactation Replicates: 12 per sex per group Purity > 98% OECD Guideline 422 GLP compliant Developmental Toxicity Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940450, 4440869, 4940388, 3041958 Oral (gavage) Pregnant Sprague-Dawley rats GD6-15 Doses: 0, 800, 2000, and 5000 mg/kg-day Replicates: 20-27 per dose NOAEL: 2000 mg/kg- day LOAEL: 5000 mg/kg- day based on decreased fetal body weight Methods: Test substance reported as CASRN 25265-71 - 8 Purity > 96% NTP GLP compliance 4440871, 4940459, 4940388 Oral (gavage) New Zealand white rabbit GD6-19 Doses: 0, 200, 400, 800, and 1200 mg/kg-day Replicates: 24 per group NOAEL: 1200 mg/kg- day Methods: Test substance reported as CASRN 25265-71 - 8 Purity > 96% NTP protocol NTP-90-CTER-126 GLP compliant Cancer Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940448, 4940455, 4940384 Oral (drinking water) Fischer 344 rats 2 years Doses: Males: 0,115, 470 and 3,040 mg/kg-day Females: 0, 140, 530 and 2,330 mg/kg- day Negative Methods: Test substance reported as CASRN 25265-71 - 8 Purity: 99% NTP Guideline GLP compliant XLII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Replicates: 50 per sex per dose 4940384, Oral (drinking B6C3F1 mice 2 years Doses: Negative Methods: 4940448 water) Males: 735, 1220, 2390 mg/kg-day Females: 575, 1040,1950 mg/kg-day Replicates: 50 per sex per dose Test substance reported as CASRN 25265-71 - 8 Purity: 99% NTP Guideline GLP compliant Genotoxicity Source Test Type & Endpoint Species & Strain (if available) Metabolic Activation Doses and Controls Results Study Details 4940446, Gene mutation Salmonella With and without Doses: 0, Negative Methods: 4940384 (in vitro) typhimurium strains TA 97, TA98, TA100, TA 1535, TA 1538 100, 333, 1000, 3333 and 10000 pg/plate Test substance reported as CASRN 25265-71 - 8 Purity >99%. NTP Guideline GLP compliant 4940463 Gene mutation Mouse lymphoma With and without Doses: 50, Negative Methods: (in vitro) L5178Y vtaells 100, 300, 500, 700, 1000, 2500 and 5000 [jg/mL Test substance reported as CASRN 25265-71 - 8 Purity not reported OECD Guideline 476 GLP compliant 4940467 Gene mutation Salmonella With and without Doses: 0.100, Negative Methods: (in vitro) typhimurium strains TA98, TA100, TA 1535, TA1537, TA 1538 0.316, 1.00, 3.16, 10.0, 31.6 and 100 [jL/plate Test substance reported as CASRN 25265-71 - 8 Purity: 99.9% OECD Guideline 471 GLP compliant XLIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 4940451, Chromosomal Mouse N/A Doses: 0, Negative Methods: 4940388 aberrations (in vivo) 500, 1000, and 2000 mg/kg Replicates: 6 per group Test substance reported as CASRN 25265-71 - 8 Purity: 99.9% OECD Guideline 474 GLP Compliant Sensitization Source Exposure Route Species & Strain (if available) Duration Doses and Replicate Number Effect Study Details 4940444, Dermal patch Human 2 day exposure, Study 1 Equivocal Methods: 4946133 observed 7 days Doses: 1%, 2%, 5%, and 10% Test substance reported as CASRN 25265-71 - 8 Purity > 96% Replicates: 34 patients GLP compliance not reported Results: Study 2 1 person had positive reaction (only to standard grade dipropylene glycol) Dose: 10% 488 subjects showed no reaction and 13 Replicates: 503 volunteers subjects showed equivocal reaction to standard grade substance 212 Males 480 subjects showed no reaction and 17 291 Females subjects showed equivocal reaction to cosmetic grade substance Irritation was indicated in 2 analytical grade and 5 cosmetic grade volunteers 4940460 Dermal Guinea pigs 6 hour exposure, Dose: 0.5 mL Negative Methods: induction repeated 3 Replicates: Test substance reported as CASRN 25265-71 - times during 2 weeks 10 animals (7 Males 8 Purity: 100% 3 Females) EPA OPP 81-6 GLP compliant Results: 1 animal displayed slight patchy erythema 24 hours after XLIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 3118622 Dermal patch Humans 24 hour exposure, scored after 48 hours; repeated for 9 applications Dose: 0.4 mL Replicates: 42 volunteers Negative Methods: Test substance reported as CASRN 25265-71 - 8 Purity not reported Modified Draize Method GLP compliance not reported Irritation Source Exposure Route Species & Strain (if available) Duration Doses Effect Study Details 4940447 Dermal Humans Daily for 14 days Doses: 0.2 mL of 50% or 100% Replicates: 26 skin- sensitive volunteers Negative Methods: Test substance: CASRN 25265-71-8 Purity not reported GLP compliance not reported Results: One volunteer had a mildly irritating response (erythema) to 100% substance before day 4 4940461 Dermal New Zealand white rabbit 4 hour exposure, observed for 72 hours Dose: 0.5 mL Replicates: 3 per sex Negative Methods: Test substance reported as CASRN 25265-71 - 8 Purity: 100% EPA OPP 81-5 GLP compliant Results: Very slight erythema observed in 1/6 animals within 45 minutes, but all test areas were normal for the remaining observation periods 4940458 Dermal patch Human 24 hour exposure Dose: 0.2 mL of 25% Replicates: 33 subjects Mildly irritating Methods: Test substance reported as CASRN 25265-71 - 8 Purity not reported GLP compliance not reported Results: At the 24-hour scoring, 4/33 subjects displayed mild erythema XLV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 3118622 Dermal Albino rabbit 24 hour exposure, observed for 72 hour Dose: 0.5 mL Replicates: 3 rabbits per group Negative Methods: Test substance reported as CASRN 25265-71 - 8 Purity not reported Draize Method GLP compliance not reported 4940453 Dermal New Zealand white rabbit 24 hour exposure, observed for 14 day Dose: 5010 mg/kg Replicates: 5 per sex Negative Methods: Test substance: CASRN 25265-71-8 Purity: 100% EPA OPP 81-2 GLP compliant Endpoints: Very slight irritation was observed in 5/10 animals 45 minutes after removal of patch, but all effects were fully reversible by 48 hours 4940449 Ocular New Zealand white rabbit Single exposure, 72 hour observation Dose: 0.1 mL Replicates: 3 per sex Negative Method: Test substance reported as CASRN 25265-71 - 8 Purity: 100% EPA OPP 81-4 GLP compliant Endpoint: 6/6 animals had conjunctival redness and 2/6 animals displayed chemosis after 1 hour, but these results were fully reversible by 24 hours 3118622 Ocular Rabbits Single exposure, observed for 7 days Dose: 0.1 mL Replicates: 3 rabbits per group Negative Method: Test substance: CASRN 25265-71-8 Purity not reported Draize Method GLP compliance not reported Results: Eye irritation did not differ between vehicle control and test material ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table B.1: Human Health Hazard Other Source Exposure Route Species & Strain (if available) Duration Doses Effect Study Details 4088550 Cell Human embryonic NA Doses: NOAEL: Methods: viability stem cells 0.0001 0.00745M Test substance reported as CASRN 25265-71-8 (hESCs) and M to 0.1 for hESCs; IC50: 0.04 M for hESCs and hPF Purity not reported human adult M GLP compliance not reported pulmonary Results: fibroblasts (hPF) In hESCs the estimated NOAEL was 0.00745M and the IC50 was 0.045M, only the highest concentration tested was significantly different from (vehicle) controls. The IC50 in hPF cells was identical (0.04M), but a reliable NOAEL could not be determined XLVII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table B.2: Environmental Hazard Aquatic Toxicity: Experimental Source Species & strain (if available) Duration Doses and Replicate Number Effect Study Details 4940438 Daphnia magna 48 hours Dose: 100 mg/L ECso >100 mg/L Methods: Test substance reported as CASRN 25265-71-8 Purity: 100% EPA 540/9-82-024, EPA-540/9-85-005 and ASTM Standards E729-88a GLP compliant 4940439 Daphnia magna 48 hours Doses: 0,12.5,25, 50, and 100 mg/L ECso >100 mg/L Methods: Test substance reported as CASRN 25265-71-8 Purity: 99.6% OECD Guideline 202 GLP compliant 4940389, 4940442 Oryzias latipes 96 hours Doses: 5 concentrations between 95 mg/L and 1000 mg/L (nominal) LCso >1000 mg/L Methods: Test substance reported as CASRN 24800-44-0 Purity: 97% OECD Guideline 203 Not GLP compliant 4940389 Selenastrum capricornutum 72 hours Doses: 5 concentrations between 95 mg/L and 1000 mg/L (nominal) ECso >1000 mg/L Methods: Test substance reported as CASRN 24800-44-0 Purity: 97% OECD Guideline 201 Not GLP compliant Aquatic Toxicity: Estimated Model Duration Species Predicted Effect Level Notes ECOSARv2.0 (Class: Neutral Organics) 96 hours Aquatic Vertebrates ECso: 18000 mg/L Physical properties used for estimation Log K0w -0.46 (exp); water solubility 1000 mg/L; melting point-40°C (exp) SMILES: 0(CC(0)C)CC(0)C ECOSARv2.0 (Class: Neutral Organics) 72 hours Green Algae ECso: 2400 Physical properties used for estimation Log K0w -0.46 (exp); water solubility 1000 mg/L; melting point-40°C (exp) SMILES: 0(CC(0)C)CC(0)C ECOSARv2.0 (Class: Neutral Organics) ChV Aquatic Vertebrates 1300 mg/L Physical properties used for estimation Log Kow -0.46 (exp); water solubility 1000 mg/L; melting point-40°C (exp) SMILES: 0(CC(0)C)CC(0)C XLVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** ECOSARv2.0 (Class: Neutral Organics) ChV Daphnia 420 mg/L Physical properties used for estimation Log K0w -0.46 (exp); water solubility 1000 mg/L; melting point-40°C (exp) SMILES: 0(CC(0)C)CC(0)C ECOSARv2.0 (Class: Neutral Organics) ChV Green Algae 370 mg/L Physical properties used for estimation Log K0w -0.46 (exp); water solubility 1000 mg/L; melting point-40°C (exp) SMILES: 0(CC(0)C)CC(0)C Table B.3: Fate Environmental Fate: Experimental Source Endpoint Duration Doses and Number of Replicates Results Study Details 4940427 O2 consumption, CO2 evolution, DOC removal 28 days Dose: 100 mg/L Readily biodegradable Methods: Test substance reported as CASRN 25265-71-8 Purity: 99.9% OECD Guideline 301F GLP compliant Endpoints: O2 consumption: 58.7% after 10 days, 84.4% after 28 days. CO2 evolution: 64.5% after 28 days. DOC removal: 93.4% after 28 days. 1763085 BOD N/A Doses: 14-6816 mg/L Insufficient O2 consumption Methods: Test substance reported as CASRN 25265-71-8 Purity not reported Standard methods (APHA195) GLP compliance not reported Endpoints: BOD < 0.001 g/g using microbial seed from supernatant of settled raw sewage. Insufficient O2 consumption 4940429 DOC removal using activated sludge inoculum 6 weeks Dose: 18.5 mg/L DOC removal 83.6% after 6 weeks Methods: Test substance reported as CASRN 25265-71-8 Purity > 99.9% OECD Guideline 301F or OECD Guideline 302A GLP compliant Endpoints: DOC removal 83.6% after 6 weeks Biodegradation from days 10-42 of 82.5-84.7% 4940432 O2 consumption, CO2 28 days Dose: 100 mg/L Readily biodegradable Method: XLIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table B.3: Fate Environmental Fate: Experimental Source Endpoint Duration Doses and Number of Replicates Results Study Details consumption, DOC removal Test substance CASRN 24800-44-0 Purity: 99.9% OECD Guideline 301F GLP compliant Results: 81.9% O2 consumption, 61% CO2 consumption, 91.7% DOC removal after 28 days 55.3% biodegradation within 10-day window 4940424 CO2 evolution and BOD removal 64 days Dose: 50.3 mg/L DOC removal showed 23.6+/- 0.3% degradation after 64 days CO2 evolution showed 17.3+/- 2.6% degradation after 62 days Methods: Test substance reported as CASRN 25265-71-8 Purity: 99.4% OECD Guideline 306 GLP compliance not reported 4940389 BOD 28 days Dose: 100 mg/L Not readily biodegradable Method: Test substance reported as CASRN 24800-44-0 Purity not reported OECD Guideline 301C GLP compliant Results: 0% degradation by TOC and 0-3% by GC after 28 days 1 -2% BOD degradation after 28 days 4940425 CO2 evolution 28 days NA Not readily biodegradable Method: Test substance reported as CASRN 24800-44-0 Purity: 95% OECD Guideline 301B GLP compliant Results: 0% degradation by DOC after 28 days 4-5% degradation by CO2 evolution after 28 days 4940426 O2 consumption 28 days NA 69% degradation after 28 days Method: L ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table B.3: Fate Environmental Fate: Experimental Source Endpoint Duration Doses and Number of Replicates Results Study Details Test substance reported as CASRN 24800-44-0 Purity: 99.43% OECD Guideline 301D GLP compliant Results: 59% in 11 days 69% degradation after 28 days 4940431 O2 consumption 28 days NA Not readily biodegradable Method: Test substance reported as CASRN 24800-44-0 Purity: 99.43% OECD Guideline 301D GLP compliant Results: 0% degradation by O2 consumption after 28day (below detection limit of <2.5% ThOD) 4940437 Toxicity to microorganisms 3 hours Doses: 10, 32,100, 320 and 1000 mg/L NOEOIOOO mg/L Methods: Test substance reported as CASRN 24800-44-0 Purity: 99.9% OECD Guideline 209 GLP compliant Results: EC50 >1000 mg/L (nominal) 4940441 Toxicity to microorganisms 18 hours Doses: Range Finding: 0.1,1, 100, and 1000 mg/L Main study: 1.95, 3.91, 7.81, 15.63, 31.25, 62.5, 125, 250, 500, and 1000 mg/L EC10 > 1000 mg/L Methods: Test substance reported as CASRN 25265-71-8 Purity: 99.9% GLP compliant Environmental Fate: Modelled Model Data Type Endpoint Predicted Endpoint Notes LI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table B.3: Fate Environmental Fate: Experimental Source Endpoint Duration Doses and Number of Replicates Results Study Details EPISuite Estimated BAF 0.9 v.4.11 EPISuite Estimated BCF 3.16 v.4.11 EPISuite v.4.11 Estimated Anaerobic biodegradation Not predicted to biodegrade quickly Probability of 0.4055. Fragment representation is valid. Fast degradation is defined as predicted probability >0.5. (BIOWIN 7) under anaerobic conditions EPI Suite For purposes of the EPI EPI Suite (Physical Property Inputs - BP = 232.8 deg C, MP = -40 deg C, VP = 0.03 mm Hg, Reference estimates, the melting WS = 1000000 mg/L, Log P = -0.7 SMILES: OC(C)COCC(C)Q point was entered as - 40 °C and the Log K0w was taken from the I CSC entry. Lll ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** B.1 References: Bates., HK; Price. CJ; Marr., M; Myers, CB; Heindel. II; Schwetz. BA. (1992a). Final report on the developmental toxicity of dipropylene glycol (CAS #25265-71-8) in New Zealand white rabbits. (NTP Study No. TER-90-14). Research Triangle Park, NC: National Toxicology Program. Bates. HK; Price. CJ; Marr. M; Myers. CB; Heindel JJ; Schwetz. BA. (1992b). Final report on the developmental toxicity of dipropylene glycol (CAS No. 25265-71-8) in Sprague-Dawley (CD (trade name)) rats. Research Triangle Park, NC: National Toxicology Program. BUA (GDCh Advisory Committee on Existing Chemicals). (1996). Dipropylene glycol. In GD BUA (Ed.). Stuttgart, Germany: S. Hirzel. ECHA (European Chemicals Agency). (1974). [(methylethylene)bis(oxy)]dipropanol: acute toxicity: inhalation: 001 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/-/registered-dossier/14788/7/3/3/?documentUUID=b b~b4fe~ 72047a3b05d2 ECHA (European Chemicals Agency). (1980). Oxydipropanol: acute toxicity: oral: 002 supporting | experimental result. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/.1.60.1.6/7/3/2/?documentl j88a-8c76-433b-993f-acc62594e680 ECHA (European Chemicals Agency). (1988). Oxydipropanol: genetic toxicity: in vitro: 002 key | experimental result. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/1 ?documentUUID=389098d4-4996-4c60-a762-d2b60df89dcc ECHA (European Chemicals Agency). (1990a). Oxydipropanol: developmental toxicity/teratogencity: 002 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration-dossier/- /registered-dossier/16016/?/9/3/?doeumentU ?6f3dc0-f578-45ab-9a89-b92637f28c00 ECHA (European Chemicals Agency). (1990b). Oxydipropanol: developmental toxicity/teratogenicity: 001 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration-dossier/- /registered-dossier/16016/7/9/3 ECHA (European Chemicals Agency). (1991a). |(methylethylene)bis(oxy)|dipropanol: biodegradation in water: screening tests: 004 supporting | experimental result, https://echa.europa.eu/registration- dossier/-/registered-dossier/14788/5/3/2/?documentUUID=caad96d0-3b36-4255-9bd2- 0e2da25ee91e ECHA (European Chemicals Agency). (1991b). |(methylethylene)bis(oxy)|dipropanol: biodegradation in water: screening tests: 005 supporting | experimental result. Helsinki, Finland. https://echa.europa.eu/registration~dossier/~/registered~ dossier/.1.4788/5/3/2/?documentL 0f8fe90-fc45-491e-b488-434e42981995 ' till ' ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** ECH.A (European Chemicals Agency). (1992a). Oxydipropanol: genetic toxicity: in vitro: 003 supporting | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/16016/7/7/2/?documentUUID=9d24fl2e-lbf0-4481-8ae5-e7640975e049 ECHA (European Chemicals Agency). (1992b). Oxydipropanol: toxicity to microorganisms. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered-dossier/.1.60.1.6/6/2/8 ECHA (European Chemicals Agency). (1993a). [(methylethylene)bis(oxy)]dipropanol: biodegradation in water: screening tests: 003 supporting | experimental result. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/.1.4788/5/3/2/?documentl I II) 10b66ef0-9fbb-4f6e-8371-693280a318dl ECHA (European Chemicals Agency). (1993b). [(methylethylene)bis(oxy)]dipropanol: repeated dose toxicity: oral: 002 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/-/registered-dossier/14788/7/6/2/?documentUUID=814b4a8c-4620-4c5c-bf90- b3f8622b63f6 ECHA (European Chemicals Agency). (1994a). |(methylethylene)bis(oxy)|dipropanol: short-term toxicity to fish: 001 key | experimental result. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/14788/6/2/2/?documentL d8cb796-a0f9-4d90-8fb2-57a6fe859ffe ECHA (European Chemicals Agency). (1994b). Oxydipropanol: biodegradation in water: screening tests: 003 supporting | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/-/registe red-dossier/ .1.6016/5/3/2/?documentUUID=4d.l.6933c-e52a-4975-84.1.6- 9c9534d5eal9 ECHA (European Chemicals Agency). (1995a). |(methylethylene)bis(oxy)|dipropanol: basic toxicokinetics: in vivo. Helsinki, Finland. https://echa.europa.eu/registration~dossier/~/registered~ dossier/.1.4788/7/2/2 ECHA (European Chemicals Agency). (1995b). Oxydipropanol: acute toxicity: dermal. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered-dossier/ .1.60.1.6/7/3/4 ECHA (European Chemicals Agency). (1995c). Oxydipropanol: acute toxicity: inhalation. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered-dossier/.1.60.1.6/7/3/3 ECHA (European Chemicals Agency). (1995d). Oxydipropanol: acute toxicity: oral: 001 key | experimental result. Helsinki, Finland. https://eeha.eiiropa.eii/registration~dossier/--/registered~ dossier/.1.60.1.6/7/3/2/?documentUUID=c8ac7136-0238-420c-bdcb-57a927cc6023 ECHA (European Chemicals Agency). (1995e). Oxydipropanol: exposure related observation in humans: other data: 001 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/-/registe red-dossier/1 > LIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** ECH.A (European Chemicals Agency). (19950. Oxydipropanol: eye irritation: in vivo. https://echa.europa.eu/registration-dossier/-/registered-dossier/ .1.60.1.6/7/4/3 ECH.A (European Chemicals Agency). (1995g). Oxydipropanol: sensitisation data (human). Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered-dossier/. 5 ECHA (European Chemicals Agency). (1995h). Oxydipropanol: short-term toxicity to aquatic invertebrates: 002 supporting | experimental result, https://echa.europa.eu/registration-dossier/- /registered-dossier/16016/6/2/4/?documentU >a63c82-fala-4621-9cf5-2fb6efdfc6a3 ECHA (European Chemicals Agency). (1995i). Oxydipropanol: skin irritation/corrosion: in vivo. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered-dossier/160.1.6/7/4/2 ECHA (European Chemicals Agency). (1995j). Oxydipropanol: skin sensitisation: in vivo (non-LLNA). https://echa.europa.eu/registration-dossier/-/registered-dossier/ .1.60.1.6/7/5/2 ECHA (European Chemicals Agency). (1997). Oxydipropanol: exposure related observations in humans: other data: 002 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration- dossier/-/registe red-dossier/ .1.60.1.6/7/1l/6/?documentUUID=d0571cec-5afe-40b6-86f9- d57dlef9c2£2 ECHA (European Chemicals Agency). (1999). Oxydipropanol: genetic toxicity: in vivo. https://eeha.europa.eu/registration~dossier/~/registered~dossi( ECHA (European Chemicals Agency). (2002). Oxydipropanol: short-term toxicity to aquatic invertebrates: 001 key | experimental result, https://echa.europa.eu/registration-dossier/- /registered-dossier/16016/6/2/4 ECHA (European Chemicals Agency). (2004a). Oxydipropanol: carcinogenicity: oral. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/16016/7/8/?documenLI I iP . 2067ce9-4d3f-474a-a0eb-e0466eaa8a37 ECHA (European Chemicals Agency). (2004b). Oxydipropanol: carcinogenicity: oral: 001 key | experimental result. https://echa.europa.eu/registration-dossier/-/registered-dossier/.1.60.1.6/7/8 ECHA (European Chemicals Agency). (2004c). Oxydipropanol: genetic toxicity: in vitro: 001 key | experimental result. Helsinki, Finland. https://echa.europa.eu/registration~dossier/--/registered-- dossier/leOle/ V/J/?documentUUID=74e5S\'° ( -l:29-4883-958e-083dla25594e ECHA (European Chemicals Agency). (2004d). Oxydipropanol: repeated dose toxicity: oral: 001 key | experimental result. Helsinki, Finland, https://eeha.europa.eu/registratk)n.~dossier/~/registered~ dossier/16016/7/6/2 ECHA (European Chemicals Agency). (2004e). Oxydipropanol: repeated dose toxicity: oral: 002 supporting | experimental result. Helsinki, Finland, https://echa.europa.eu/registration-dossier/- /registe red-dossier/.1.60.1.6/7/6/2/?docume ?8 8 8e96-d05 d-445.1. -9709-64fabae2.1. fbc LV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** ECH.A (European Chemicals Agency). (2004f). Oxydipropanol: repeated dose toxicity: oral: 003 supporting | experimental result. https://echa.europa.eu/registration-dossier/-/registered- dossier/16016/7/6/2/?documentUUID=9796c071-d039-468a-b2fl-0493582fdc50 ECHA (European Chemicals Agency). (2004g). Oxydipropanol: repeated dose toxicity: oral: 004 supporting | experimental result. https://echa.europa.eu/registration-dossier/-/registered- dossier/.1.60.1.6/7/6/2/?documentl sb50875-5f7d-4 Ie6-802b-de9b6.1.8599ec ECHA (European Chemicals Agency). (2007a). [(methylethylene)bis(oxy)]dipropanol: biodegradation in water: screening tests: 001 key | experimental result. Helsinki, Finland. https://eeha.eiiropa.eii/registration~dosgier/--/registered~ dossier/.1.4788/5/3/2/?documentl f8b2£2f-7880-495b-adle-7a003£2c96c7 ECHA (European Chemicals Agency). (2007b). [(methylethylene)bis(oxy)]dipropanol: dermal absorption in vitro/ex vivo. https://echa.europa.eu/registration-dossier/-/registered-dossier/14788/7/2/3 ECHA (European Chemicals Agency). (2007c). Oxydipropanol: biodegradation in water: screening tests: 001 key | experimental result. Helsinki, Finland, https://echa.europa.eu/registration-dossier/- /registered-dossier/16016/5/3/2 ECHA (European Chemicals Agency). (2007d). Oxydipropanol: biodegradation in water: screening tests: 002 key | experimental result. https://echa.europa.eu/registratk)n~dossier/~/registered~ dossier/.1.60.1.6/5/3/2/?documentl 2502e63-7f7b-4797-aaba-87666cb57def ECHA (European Chemicals Agency). (2010). [(methylethylene)bis(oxy)]dipropanol: toxicity to microorganisms: 001 key | experimental result. Helsinki, Finland. https://echa.europa.eu/registration-dossier/-/registered- dossier/14788/6/2/8/?documentl 5e7699a-lff8-4aee-a8fl5-fba87bb72e52 Fasano., W'J. (2007). Dipropylene glycol: in vitro dermal absorption rate testing [TSCA Submission|. Fasano, WJ. https://ehemyiew.epa.goy/ehemyiew/proxy?ftleriaroe=2008~l~8EHO~08~ .1.6930B 8eho 01 OS 16930b.pdf Fasano. WJ; ten Berge. W; Banton. MI; Heneweer. M; Moore. NP. (2011). Dermal penetration of propylene glycols: Measured absorption across human abdominal skin in vitro and comparison with a QSAR model. Toxicol In Vitro 25: 1664-1670. http://dx.doi.org/.' /i.tiv.2011.07.003 Johansen. ID; Jemec. G6E; Rastogi. SC. (1995). Contact sensitization to dipropylene glycol in an eczema population [Abstract]. Contact Derm 33: 211-212. http://dx.doi.org/10.1111/i..1.600- 0536.1995 .tb00560.x Leberco Labs (Lcberco Laboratories). (1994). Letter from [] to usepa submitting irritation toxicity studies of 2-propanol, l,l'-oxybis- in the rabbit dated 03/24/94 (sanitized). (86940000234S). LVI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Meshako, E; Bleekroanti, CA; Goltz. MN. (1999). Biodegradability and microbial toxicity of aircraft fuel system icing inhibitors. Environ Toxicol 14: 383-390. http://dx.doi.org/10.1002/(SICI) 1522- 7278(1999)14:4<383::AID-TOX2>3.0.CO:2-M NTP (National Toxicology Program). (2004). NTP technical report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS NO. 25265-71-8) in F344/N rats and B6C3F1 mice (pp. 6- 260). Research Triangle Park, NC: U.S Department of Health and Human Services. Public Health Service. National Institutes of Health, https://ntp.niehs.nih.gov/ntp/htdocs/lt rpts/tr511 .pdf QECD (Organisation for Economic Co-operation and Development). (1994). SIDS Initial Assessment Report for SIAM 2 (Paris, 4-6 July 1994)Tripropylene glycol: CAS No: 24800-440. https://lipvchemicals.oecd.Org/U I/handler.axd?id=00205ee6~f694~448b~bbb2~be4.1.2.1.e9a7fe QECD (Organisation for Economic Co-operation and Development). (2001). Dipropylene glycol (mixed isomers and dominant isomer Cas No: 25265-71-8 and 110-98-5). http://www.inchem.org/documents/sids/sids/25265-71-8.pdf iVIl' ------- * * * Proposal Draft Do Not Cite, Quote or Release During the Review * * * Appendix C: Literature Search Outcomes C.1 Literature Search and Review This section briefly describes the literature search and review process, search terms, and search outcomes for the hazard screening of dipropylene glycol. Search outcomes and reference details are provided on the candidate's HERO35 project page. EPA created a fit-for-purpose process to transparently document the literature search and review36 of available hazard and fate information for low-priority substance (LPS) candidates. References from peer- reviewed primary sources, grey sources,37 and other sources were identified, screened at the title/abstract and full text level, and evaluated for data quality based on discipline-specific criteria. An overview of the literature search and review process is illustrated in Figure C I. Figure C.1: Overview of the Literature Search and Review Process yf\ References available at title/abstract screening References available at data quality evaluation References included in LPS screening reviews References available at full text screening References excluded at full text screening References excluded at title/abstract screening References excluded at data quality evaluation References available from grey literature and other sources References available from primary peer- reviewed sources C.1.1 Search for Analog Data To supplement the information on the candidate chemical, dipropylene glycol, the following LPS candidates were used as analogs for read-across: I. r-dimcthyldiethylcnc glycol (CASRN 110-98-5) and tripropylene glycol (CASRN 24800-44-0). For more details and justification on analogs, see section 6.1.1. Analogs were used to fill data gaps on endpoints for which dipropylene glycol lacked quality data, such as 35 The HERO low-priority substance candidate project pages are accessible to the public at littus://hero. epa. go v/hero/. * Discussed in the document "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA", also released at proposal. Grey literature and additional sources are the broad category of studies not found in standard, peer-reviewed literature database searches. This includes U.S. and international government agency websites, non-government organization (NGO) websites, and data sources that are difficult to find, or are not included, in the peer-reviewed databases, such as white papers, conference proceedings, technical reports, reference books, dissertations, and information on various stakeholder websites. LVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** reproductive toxicity, and to add to the weight of the scientific evidence. Analog references were searched, screened and evaluated using the same process as references on dipropylene glycol described above.36 Dipropylene glycol and the two analogs mentioned above fall under the glycol cluster in HERO. C.1.2 Search Terms and Results EPA began the literature review process for the hazard screening of dipropylene glycol by developing search terms. To gather publicly available information, specific search terms were applied for each discipline and across databases and grey literature sources. Table C. 1.1 lists the search terms used in the database search of peer -reviewed literature for the glycol cluster including dipropylene glycol. For grey literature and other secondary sources, Table C.1.2 lists the search terms used for the glycol cluster. Table C.1: Search Terms Used in Peer-Reviewed Databases Discipline Database Search terms Human Health PubMed 25265-71-8[rn] OR 110-98-5[rn] OR 24800-44-0[rn] OR "((1-methyl-1,2- ethanediyl)bis(oxy))bispropanol"[tw] OR "((Methylethylene)bis(oxy))dipropanol"[tw] OR "1,1 '-Dimethyldiethylene glycol"[tw] OR "1,1'-Oxybis(2-propanol)"[tw] OR "1,1'-Oxybis-2- propanol"[tw] OR "1,1 -Oxydi-2-propanol"[tw] OR "1,1 -Oxydipropan-2-ol"[tw] OR "2,2'- Dihydroxydipropyl ether"[tw] OR "2-(2-(2-Hydroxypropoxy)propoxy)-1-propanol"[tw] OR "2-Propanol, 1,1'-oxybis-"[tw] OR "2-Propanol, 1,1'-oxydi-"[tw] OR "4-Oxa-2,6- heptandiol"[tw] OR "4-Oxaheptane-2,6-diol"[tw] OR "ADK DPG-RF"[tw] OR "Bis(2- hydroxypropyl) ether"[tw] OR "Bis(3-hydroxypropyl)ether"[tw] OR "Diisopropylene glycol"[tw] OR "Dipropylene glycol"[tw] OR "DIPROPYLENEGLYCOL"[tw] OR "DIPROPYLENGLYKOL"[tw] OR "Dowanol DPG"[tw] OR "DPG-FC"[tw] OR "DPG- RF"[tw] OR "NIAX catalyst D-19"[tw] OR "oxidipropanol"[tw] OR "Oxybispropanol"[tw] OR"Oxydipropanol"[tw] OR"Propanol, ((1-methyl-1,2-ethanediyl)bis(oxy))bis-"[tw] OR "Propanol, oxybis-"[tw] OR "Tripropylene glycol"[tw] Toxline (25265-71-8[rn] OR 110-98-5[rn] OR 24800-44-0[rn] OR "((1-methyl-1,2- ethanediyl)bis(oxy))bispropanol" OR"((Methylethylene)bis(oxy))dipropanol" OR "1,1'- Dimethyldiethylene glycol" OR "1,1'-Oxybis(2-propanol)" OR "1,1 '-Oxybis-2-propanol" OR "1,1 '-Oxydi-2-propanol" OR "1,1 '-Oxydipropan-2-ol" OR "2,2'-Dihydroxydipropyl ether" OR "2-(2-(2-Hydroxypropoxy)propoxy)-1-propanol" OR "2-Propanol, 1,1 '-oxybis-" OR "2-Propanol, 1,1'-oxydi-" OR "4-Oxa-2,6-heptandiol" OR "4-Oxaheptane-2,6-diol" OR "ADK DPG-RF" OR"Bis(2-hydroxypropyl) ether" OR "Bis(3-hydroxypropyl)ether" OR "Diisopropylene glycol" OR "Dipropylene glycol" OR "DIPROPYLENEGLYCOL" OR "DIPROPYLENGLYKOL" OR "Dowanol DPG" OR "DPG-FC" OR "DPG-RF" OR "NIAX catalyst D-19" OR "oxidipropanol" OR "Oxybispropanol" OR "Oxydipropanol" OR "Propanol, ((1 -methyl-1,2-ethanediyl)bis(oxy))bis-" OR "Propanol, oxybis-" OR "Tripropylene glycol") AND (ANEUPL [org] OR BIOSIS [org] OR CIS [org] OR DART [org] OR EMIC [org] OR EPIDEM [org] OR FEDRIP [org] OR HEEP [org] OR HMTC [org] OR IPA [org] OR RISKLINE [org] OR MTGABS [org] OR NIOSH [org] OR NTIS [org] OR PESTAB [org] OR PPBIB [org]) AND NOT PubMed [org] AND NOT pubdart [org] TSCATS1 (25265-71-8 [rn] OR 110-98-5 [rn] OR24800-44-0 [rn]) AND (TSCATS [org]) AND NOT PubMed [org] AND NOT pubdart [org] WOS TS=("25265-71 -8" OR "110-98-5" OR "24800-44-0" OR "((1-methyl-1,2- ethanediyl)bis(oxy))bispropanol" OR"((Methylethylene)bis(oxy))dipropanol" OR "1,1'- Dimethyldiethylene glycol" OR "1,1'-Oxybis(2-propanol)" OR "1,1 '-Oxybis-2-propanol" LIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table C.1: Search Terms Used in Peer-Reviewed Databases OR "1,1 '-Oxydi-2-propanol" OR "1,1 "-Oxydipropan-2-ol" OR "2,2'-Dihydroxydipropyl ether" OR"2-(2-(2-Hydroxypropoxy)propoxy)-1-propanol" OR "2-Propanol, 1,1-oxybis-" OR "2-Propanol, 1,1'-oxydi-" OR "4-Oxa-2,6-heptandiol" OR "4-Oxaheptane-2,6-diol" OR "ADK DPG-RF" OR"Bis(2-hydroxypropyl) ether" OR "Bis(3-hydroxypropyl)ether" OR "Diisopropylene glycol" OR "Dipropylene glycol" OR "DIPROPYLENEGLYCOL" OR "DIPROPYLENGLYKOL" OR "Dowanol DPG" OR "DPG-FC" OR "DPG-RF" OR "NIAX catalyst D-19" OR "oxidipropanol" OR "Oxybispropanol" OR "Oxydipropanol" OR "Propanol, ((1 -methyl-1,2-ethanediyl)bis(oxy))bis-" OR "Propanol, oxybis-" OR "Tripropylene glycol") lndexes=SCI-EXPANDED, CPCI-S, CPCI-SSH, BKCI-S, BKCI-SSH, CCR-EXPANDED, IC Timespan=AII years Environmental Hazard WOS Same as human health strategy synonyms only Toxline Same as human health strategy synonyms only TSCATS1 Same as human health strategy CASRN only Proquest TITLE=("25265-71 -8" OR "1,1'-Oxybis 2-propanol" OR "1,1 '-Oxybis-2-propanol" OR "1,1 "-Oxydi-2-propanol" OR"1,1'-Oxydipropan-2-ol" OR "2-Propanol, 1,1-oxybis-" OR "Bis 2-hydroxypropyl ether" OR "Dipropylene glycol" OR "DIPROPYLENEGLYCOL" OR "Propanol, oxybis-" OR "Tripropylene glycol") ABSTRACT=("25265-71 -8" OR "1,1'-Oxybis 2-propanol" OR "1,1 '-Oxybis-2-propanol" OR"1,1'-Oxydi-2-propanol" OR"1,1'-Oxydipropan-2-ol" OR "2-Propanol, 1,1 -oxybis-" OR "Bis 2-hydroxypropyl ether" OR "Dipropylene glycol" OR "DIPROPYLENEGLYCOL" OR "Propanol, oxybis-" OR "Tripropylene glycol") SUBJECT=("25265-71 -8" OR "1,1'-Oxybis 2-propanol" OR "1,1 '-Oxybis-2-propanol" OR "1,1'-Oxydi-2-propanol" OR"1,1'-Oxydipropan-2-ol" OR "2-Propanol, 1,1'-oxybis-" OR "Bis 2-hydroxypropyl ether" OR "Dipropylene glycol" OR "DIPROPYLENEGLYCOL" OR "Propanol, oxybis-" OR "Tripropylene glycol") ("110-98-5" OR "24800-44-0" OR" 1 -methyl-1,2-ethanediyl bis oxy bispropanol" OR "Methylethylene bis oxydipropanol" OR "1,1 '-Dimethyldiethylene glycol" OR "2,2'- Dihydroxydipropyl ether" OR "2- 2- 2-Hydroxypropoxy propoxy -1-propanol" OR "2- Propanol, 1,1'-oxydi-" OR "4-Oxa-2,6-heptandiol" OR "4-Oxaheptane-2,6-diol" OR "ADK DPG-RF" OR "Bis 3-hydroxypropyl ether" OR "Diisopropylene glycol" OR "DIPROPYLENGLYKOL" OR "Dowanol DPG" OR "DPG-FC" OR "DPG-RF" OR "NIAX catalyst D-19" OR "oxidipropanol" OR "Oxybispropanol" OR "Oxydipropanol" OR "Propanol, 1-methyl-1,2-ethanediyl bis oxy bis-") Fate WOS Same as human health strategy synonyms only Table C.2: Search Terms Used in Grey Literature and Additional Sources Chemical Search terms Glycol cluster (1,1'- Dimethyldiethylene glycol; dipropylene glycol, tripropylene glycol) Searched as a string or individually depending on resource: "25265-71-8" OR "110-98-5" OR "24800-44-0" OR "Dipropylene glycol" OR"Dipropyleneglycol" OR "Propanol, oxybis-" OR "Tripropylene glycol" After the search terms were applied, more than 620 references were returned by all search efforts across peer-reviewed databases and grey literature sources. The total number of references include database results, additional strategies, and analog searches. All references from the search efforts were screened LX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** and evaluated through the LPS literature search and review process.36 Of these, 71 references were included for data evaluation and used to support the designation of dipropylene glycol as LPS. The included hazard and fate references are listed in the bibliography of Appendix B. C.2 Excluded Studies and Rationale This section lists the excluded references, by HERO ID, found to be off-topic or unacceptable for use in the hazard screening of dipropylene glycol. The excluded references are organized by discipline (human health hazard, environmental hazard, and fate), presented along with a rationale based on exclusion criteria. The criteria36 was used to determine off-topic references in the title/abstract or full text screening and to determine unacceptable references in the data quality evaluation are provided in the form of questions. C.2.1 Human Health Hazard Excluded References For the screening review of dipropylene glycol, EPA excluded a total of 539 references when assessing human health hazard. Off-topic references (e.g., studies that did not contain information relevant to human health) were excluded at either title/abstract screening (see Table C.3), or full-text screening (see Table C.4). Unacceptable references (e.g., studies that did not meet data quality metrics) were excluded at full-text screening (see Tables C.5 and C.6). Off-topic and unacceptable references are displayed next to the corresponding exclusion criteria. Table C.3: Off-Topic References Excluded at Title/Abstract Screening for Human Health Hazard Reference excluded (HERO ID) because the reference did NOT contain information needs38 relevant to human health hazard 33975 4949055 4948960 4947155 4705492 1201178 4949084 4948984 4948886 4946188 44187 4949056 4948961 4947156 4706833 1204953 4949085 4948985 4948887 4946189 404898 4949058 4948962 4947159 4738360 1249186 4949086 4948986 4948890 4946190 628230 4949060 4948963 4947160 4738993 1254062 4949087 4948988 4948891 4946193 628727 4949061 4948964 4947161 4742957 1314113 4949089 4948989 4948892 4946194 635083 4949063 4948965 4947175 4828940 1316100 4949090 4948990 4948893 4946210 744085 4949064 4948966 4947177 4828943 1321888 4949092 4948991 4948894 4946247 789593 4949065 4948967 4947178 4847997 1458307 4949094 4948992 4948895 4946257 789651 4949066 4948968 4947179 4853443 1496934 4949095 4948993 4948896 4946258 926985 4949067 4948969 4947182 4909646 1549118 4949096 4948994 4948898 4946259 992939 4949068 4948970 4947185 4940595 1580047 4949098 4948995 4948899 4946263 1058389 4949070 4948971 4947187 4940694 1611582 4949099 4948996 4948900 4946320 1058433 4949071 4948972 4947189 4940855 1612753 4949100 4948997 4948902 4946322 1112905 4949072 4948974 4947194 4941419 1615034 4949102 4948998 4948904 4946324 38 Hie information needs for human health hazard includes a list of study characteristics pertaining to the study population/test organism, types of exposures and routes, me of controls, type and level of effects. A complete list of the information needs is provided in Table A1 of the "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA". These information needs helped guide the development of questions for title/abstract and full-text screening. LXI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 1124442 4949074 4948975 4947200 4945941 1689217 4949103 4948999 4948905 4946329 1124901 4949075 4948977 4947201 4946008 1763085 4949104 4949000 4948906 4946359 1142139 4949076 4948978 4947202 4946061 1763087 4949105 4949001 4948909 4946360 1153582 4949078 4948979 4947203 4946132 1763125 4949106 4949002 4948911 4946361 1156301 4949080 4948980 4947204 4946147 1763137 4949108 4949003 4948912 4946374 1167387 4949081 4948981 4947223 4946178 1763157 4949109 4949004 4948913 4946375 1201159 4949082 4948982 4947224 4946179 1781960 4949110 4949005 4948914 4946376 1201176 4949083 4948983 4948885 4946180 1808388 4949111 4949006 4948915 4946380 3036899 4949156 4949040 4948950 4947131 1808755 4949112 4949007 4948916 4946387 3037885 4949157 4949042 4948951 4947132 1865871 4949113 4949009 4948918 4946408 3038973 4949158 4949044 4948952 4947135 1955931 4949116 4949010 4948919 4946410 3039406 4949159 4949045 4948953 4947136 1967450 4949117 4949011 4948920 4946411 3039791 4951048 4949046 4948954 4947137 1970619 4949118 4949012 4948921 4946419 3041527 4951050 4949047 4948955 4947138 2231679 4949119 4949013 4948922 4946423 3041622 4951055 4949049 4948956 4947140 2232056 4949120 4949015 4948923 4946506 3041638 4951170 4949051 4948958 4947141 2232422 4949121 4949016 4948925 4946513 3041935 4951176 4949052 4948959 4947154 2232425 4949122 4949017 4948926 4946538 3047394 4951181 4949053 4339757 4576534 2232427 4949123 4949018 4948927 4946547 3051635 4951206 4949054 4376725 4579583 2232444 4949126 4949020 4948928 4946614 3051709 4951208 3753956 4388064 4583202 2232562 4949128 4949021 4948930 4946615 3103598 4951228 3823035 4391261 4656492 2273142 4949129 4949022 4948931 4946617 3114932 4428638 3830342 4395587 4660346 2292715 4949130 4949023 4948932 4946619 3115961 4428838 3830898 4398518 4704876 2302957 4949131 4949024 4948933 4946620 3119596 4433785 3846566 4399866 3577212 2530089 4949132 4949026 4948934 4946621 3225794 4436364 3847436 4400649 3577235 2563138 4949134 4949027 4948935 4946623 3374286 4436864 3874693 4404349 3590105 2692340 4949135 4949028 4948936 4947105 3402924 4438060 4146480 4408404 3619406 2745927 4949138 4949029 4948938 4947106 3445046 4438415 4148076 4420372 3625221 2824290 4949140 4949030 4948940 4947107 3476490 4425601 4148079 4420932 4275583 2875983 4949141 4949031 4948942 4947108 3477473 4426820 4168926 4420947 4276472 2883990 4949142 4949032 4948943 4947109 3491334 3559324 4173202 4421954 4423539 2887419 4949149 4949033 4948944 4947110 3539276 3562800 4222683 4948949 4947130 2892020 4949150 4949034 4948946 4947111 3009070 4949153 4949037 4948948 4947115 2978028 4949152 4949035 4948947 4947113 3036268 4949154 4949039 Reference excluded (HERO ID because the reference primarily contained in silico data N/A. K XII ' ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table C.4: Screening Questions and Off-Topic References Excluded at Full Text Screening for Human Health Hazard Question Off-topic if answer is: References excluded (HERO ID) Does the reference contain No 1322754 information pertaining to a low- 1629162 priority substance candidate? 1776453 1875316 2301122 2301139 3041082 4219489 4862648 4940454 4941418 4946053 4947114 4951209 61412 824457 1744616 1744618 3039593 4441664 4442235 4862648 4940287 4940288 4940320 4940383 4940385 4940387 4940395 4940392 4946053 4948456 4949088 4951173 4951178 What type of source is this Review article or book chapter that 1004739 reference? contains only citations to primary 3038211 literature sources 4940386 4946377 628176 3036785 What kind of evidence does this In silico studies that DO NOT N/A. reference primarily contain? contain experimental verification The following question apply to HUMAN evidence only Does the reference report an No N/A. exposure route that is or is LXIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** presumed to be by an inhalation, oral, or dermal route? Does the reference report both test No N/A. substance exposure(s) AND related health outcome(s)? If the reference reports an exposure No 4951213 to a chemical mixture, are measures of the test substance or related metabolite(s) reported independently of other chemicals? Note: If the paper does not pertain to mixtures, choose "Not Applicable". The following question apply to ANIMAL evidence only Does the reference report an No N/A. exposure route that is by inhalation, oral, or dermal route? Does the reference report both test No N/A. substance-related exposure(s) AND related health outcome(s)? Does the reference report the No N/A. duration of exposure? Does the reference report an No 4951261 exposure to the test substance only 4951218 (i.e. no mixtures with the exception 4951185 of aqueous solutions and 1230541 reasonable impurities and byproducts)? Does the paper report a negative No39 4951261 control that is a vehicle control or no treatment control? The following questions apply to MECHANISTIC/ALTERNATIVE TEST METHODS evidence only Does the reference report a No 3036587 negative control that is a vehicle control or no treatment control? Does the reference report an No N/A. exposure to the test substance only (i.e. no mixtures with the exception of aqueous solutions and reasonable impurities and byproducts)? For genotoxicity studies only: Does No 3036587 the study use a positive control? 39 Except for acute mammalian toxicity and skin and eye irritation studies, where the use of a negative control may not be required (e.g., OECD 403 Acute Inhalation Toxicity Guidelines). LXIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table C.5: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Human Health Hazard - Animal Data Quality Metric Unacceptable if: References excluded (HERO ID) Metric 1: Test Substance Identity The test substance identity cannot be determined from the information provided (e.g., nomenclature was unclear and CASRN or structure were not reported). OR For mixtures, the components and ratios were not characterized or did not include information that could result in a reasonable approximation of components. N/A. Metric 2: Negative and Vehicle Controls A concurrent negative control group was not included or reported. OR The reported negative control group was not appropriate (e.g., age/weight of animals differed between control and treated groups). N/A. Metric 3: Positive Controls When applicable, an appropriate concurrent positive control (i.e., inducing a positive response) was not used. N/A. Metric 4: Reporting of Doses/Concentrations Doses/concentrations were not reported and could not be calculated using default or reported estimates of body weight and diet/water intake (e.g., default intake values are not available for pregnant animals). 1763148 3041958 4940388 4940524 4940510 Metric 5: Exposure Duration The duration of exposure was not reported. OR The reported exposure duration was not suited to the study type and/or outcome(s) of interest (e.g., <28 days for repeat dose). 4940388 4940389 4941420 4946133 Metric 6: Test Animal Characteristics The test animal species was not reported. OR The test animal (species, strain, sex, life-stage, source) was not appropriate for the evaluation of the specific outcome(s) of interest (e.g., genetically modified animals, strain was uniquely susceptible or resistant to one or more outcome of interest). 4941420 1763148 4940389 4940388 3041958 4946133 Metric 7: Number of Animals Per Group The number of animals per study group was not reported. OR N/A. LXV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** The number of animals per study group was insufficient to characterize toxicological effects (e.g., 1-2 animals in each group). Metric 8: Outcome Assessment Methodology The outcome assessment methodology was not sensitive for the outcome(s) of interest (e.g., evaluation of endpoints outside the critical window of development, a systemic toxicity study that evaluated only grossly observable endpoints, such as clinical signs and mortality, etc.). 1763148 2282271 4940388 4940389 4941420 4946133 Metric 9: Reporting of Data Data presentation was inadequate (e.g., the report does not differentiate among findings in multiple exposure groups). OR Major inconsistencies were present in reporting of results. 4940388 4940524 4941420 2282271 4442235 4940303 4940394 4946044 4940452 Table C.6: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Human Health Hazard - In Vitro Data Quality Metric Unacceptable if: References excluded (HERO ID) Metric 1: Test Substance Identity The test substance identity or description cannot be determined from the information provided (e.g., nomenclature was unclear and CASRN or structure were not reported). OR For mixtures, the components and ratios were not characterized or did not include information that could result in a reasonable approximation of components. 3039551 Metric 2: Negative Controls A concurrent negative control group was not included or reported. OR The reported negative control group was not appropriate (e.g., different cell lines used for controls and test substance exposure). N/A. Metric 3: Positive Controls A concurrent positive control or proficiency group was not used. N/A. Metric 4: Assay Type The assay type was not reported. OR The assay type was not appropriate for the study type or outcome of interest (e.g., in vitro skin corrosion N/A. LXVI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** protocol used for in vitro skin irritation assay). Metric 5: Reporting of Concentration The exposure doses/concentrations or amounts of test substance were not reported. N/A. Metric 6: Exposure Duration No information on exposure duration(s) was reported. OR The exposure duration was not appropriate for the study type and/or outcome of interest (e.g., 24 hours exposure for bacterial reverse mutation test). 4940521 4940522 4940389 2282271 Metric 7: Metabolic Activation No information on the characterization and use of a metabolic activation system was reported. OR The exposure duration was not appropriate for the study type and/or outcome of interest (e.g., 24 hours exposure for bacterial reverse mutation test). N/A. Metric 8: Test Model The test model was not reported OR The test model was not routinely used for evaluation of the specific outcome of interest. N/A. Metric 9: Outcome Assessment Methodology The outcome assessment methodology was not reported. OR The assessment methodology was not appropriate for the outcome(s) of interest (e.g., cells were evaluated for chromosomal aberrations immediately after exposure to the test substance instead of after post- exposure incubation period). 4940451 4940388 C.2.2 Environmental Hazard For the screening review of LPS candidate dipropylene glycol, EPA excluded a total of 547 references when assessing environmental hazard. Off-topic environmental hazard references excluded at title/abstract screening are listed in Table C.7, and those excluded at full-text screening are listed in Table C.8. References in Table C.9 represent unacceptable studies based on specific data quality metrics for environmental hazard. Off-topic and unacceptable references are displayed next to the corresponding exclusion criteria. Xv I ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table C.7: Off-Topic References Excluded at Title/Abstract Screening for Environmental Hazard Reference excluded (HERO ID) because the reference did NOT contain information needs40 relevant to environmental hazard 44187 4440871 4949112 4948988 4946374 2892020 4738993 1744618 4949052 4948891 404898 4441664 4949113 4948989 4946375 2978028 4742957 1763125 4949053 4948892 635083 4442235 4949116 4948990 4946376 3009070 4828940 1763137 4949054 4948893 744085 4940392 4949117 4948991 4946377 3036268 4828943 1763148 4949055 4948894 789593 4940395 4949118 4948992 4946380 3036587 4847997 1763157 4949056 4948895 789651 4941420 4949119 4948993 4946387 3036785 4853443 1776453 4949058 4948896 824457 4944882 4949120 4948994 4946408 3036899 4862648 1808755 4949060 4948898 926985 4946008 4949121 4948995 4946419 3037885 4909646 2112816 4949061 4948899 1058389 4946016 4949122 4948996 4946513 3038211 4940595 2301122 4949063 4948900 1058433 4946044 4949123 4948997 4946538 3038973 4940694 2301139 4949064 4948902 1112905 4946053 4949126 4948998 4946547 3039406 4940855 2745927 4949065 4948904 1124442 4946054 4949128 4948999 4946614 3039551 4941418 3041082 4949066 4948905 1124901 4946055 4949129 4949001 4946615 3039791 4941419 3041527 4949067 4948906 1142139 4946135 4949130 4949002 4946617 3041935 4945941 3041622 4949068 4948909 1153582 4946142 4949132 4949003 4946619 3114932 4946061 3041638 4949070 4948911 1156301 4946194 4949134 4949004 4946620 3115961 4946132 3103598 4949071 4948912 1167387 4946244 4949135 4949005 4946623 3225794 4946133 3118622 4949072 4948913 1201159 4946247 4949138 4949006 4947105 3374286 4946147 4222683 4949074 4948914 1201176 4946261 4949140 4949007 4947107 3402924 4946178 4259576 4949075 4948915 1201178 4946314 4949141 4949009 4947108 3445046 4946179 4440869 4949076 4948916 1204953 4946316 4949142 4949010 4947109 3476490 4946180 4948954 4949078 4948918 1249186 4946333 4949149 4949011 4947110 3477473 4946188 4948955 4949080 4948919 1321888 4946334 4949150 4949012 4947111 3491334 4946189 4948956 4949081 4948920 1458307 4946361 4949152 4949013 4947113 3539276 4946190 4948958 4949082 4948921 1496934 4946362 4949153 4949015 4947114 3559324 4946191 4948959 4949083 4948922 1549118 4946363 4949154 4949016 4947115 3562800 4946193 4948960 4949084 4948923 1611582 4946410 4949156 4949017 4947130 3577212 4946210 4948961 4949085 4948925 1612753 4946411 4949157 4949018 4947131 3577235 4946257 4948962 4949086 4948926 1615034 4946412 4949158 4949020 4947132 3590105 4946258 4948963 4949087 4948927 1689217 4946414 4949159 4949021 4947135 3619406 4946259 4948964 4949088 4948928 1781960 4946416 4951181 4949022 4947136 3625221 4946263 4948965 4949089 4948930 1808388 4946420 1763085 4949023 4947137 3753956 4946322 4948966 4949090 4948931 1865871 4946423 1763087 4949024 4947138 3830342 4946324 4948967 4949092 4948932 1875316 4946424 4946320 4949026 4947140 3830898 4946329 4948968 4949094 4948933 1955931 4946506 4949131 4949027 4947141 3846566 4946359 4948969 4949095 4948934 1967450 4946511 992939 4949028 4947155 3847436 4946360 4948970 4949096 4948935 1970619 4946541 3051635 4949029 4947156 3874693 4420932 4948971 4949098 4948936 2231679 4946621 3051709 4949030 4947159 4088550 4420947 4948972 4949099 4948938 2232056 4947224 4951048 4949031 4947160 4146480 4421954 4948974 4949100 4948940 2232422 4948456 2282271 4949032 4947161 4148076 4423539 4948975 4949102 4948942 2232425 4949000 33975 4949033 4947175 4148079 4425601 4948977 4949103 4948943 2232427 4951050 61412 4949034 4947177 4168926 4426820 4948978 4949104 4948944 2232444 4951055 628176 4949035 4947182 4173202 4428638 4948979 4949105 4948946 2232562 4951170 628230 4949037 4947185 4275583 4428838 4948980 4949106 4948947 2273142 4951173 628727 4949039 4947189 4276472 4433785 4948981 4949108 4948948 2292715 4951176 1004739 4949040 4947201 4339757 4436364 4948982 4949109 4948949 2302957 4951185 1230541 4949042 4947202 4376725 4436864 4948983 4949110 4948950 LXVIII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 2563138 4951207 1254062 4949044 4947203 4388064 4438060 4948984 4949111 4948951 2692340 4951209 1314113 4949045 4947204 4391261 4438415 4948985 4579583 4948952 2824290 4951213 1316100 4949046 4948885 4395587 4576534 4948986 4583202 4948953 2875983 4951218 1322754 4949047 4948886 4398518 4404349 4705492 4660346 4420372 2883990 4951261 1580047 4949049 4948887 4399866 4408404 4706833 4704876 4400649 2887419 4738360 1629162 4949051 4948890 Reference excluded (HERO ID) because the reference did NOT present quantitative environmental hazard data N/A. Table C.8: Screening Questions and Off-Topic References Excluded at Full Text Screening for Environmental Hazard Question Off-topic if answer is: References excluded (HERO ID) Does the reference contain information pertaining to a low- priority substance candidate? No 1580138 4731313 4851358 4951178 1744616 4940286 4951206 4951228 4940436 4947106 4951208 What type of source is this reference? Review article or book chapter that contains only citations to primary literature sources 4219489 Is quantitative environmental hazard data presented? No N/A. Is this primarily a modeling/simulation study? [Note: select "No" if experimental verification was included in the study] Yes N/A. Is environmental hazard data presented for standard or non- standard aquatic or terrestrial species (fish, invertebrates, microorganisms, non-mammalian terrestrial species)? No N/A. Is exposure measured for the target substance or is the test substance a mixture (except for reasonable impurities, byproducts, and aqueous solutions) or formulated product? Mixture N/A. Formulated Product N/A. 40 Hie information needs for environmental hazard includes a list of study characteristics pertaining to the test organism/species, type and level of effects, and me of controls. A complete list of the information needs is provided in Table A2 of the "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA". These information needs helped guide the development of questions for title/abstract and full-text screening. LXIX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Does the reference report a duration of exposure? No N/A. Does the reference report a No 7504 negative control that is a vehicle 4940435 control or no treatment control? 4940366 4940397 Does the reference include endpoints in the information needs? No N/A. Table C.9: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Environmental Hazard Question Unacceptable if: References excluded (HERO ID) Metric 1: Test Substance Identity The test substance identity or description cannot be determined from the information provided (e.g., nomenclature was unclear, CASRN or structure were not reported, substance name/ description does not match CASRN). OR For mixtures, the components and ratios were not characterized or did not include information that could result in a reasonable approximation of components. N/A. Metric 2: Negative Controls A concurrent negative control group was not included or reported. 4951174 4951208 Metric 3: Experimental System The experimental system (e.g., static, semi-static, or flow-through regime) was not described. 4940436 4940440 4951174 4940388 3041958 Metric 4: Reporting of Concentrations Test concentrations were not reported. 4951174 4951208 Metric 5: Exposure Duration The duration of exposure was not reported. OR The reported exposure duration was not suited to the study type and/or outcome(s) of interest (e.g., study intended to assess effects on reproduction did not expose organisms for an acceptable period of time prior to mating). 4951208 4951174 Metric 6: Test Organism Characteristics The test species was not reported. OR The test species, life stage, or age was not appropriate for the outcome(s) of interest. N/A. Metric 7: Outcome Assessment Methodology The outcome assessment methodology was not reported. N/A. Metric 8: Reporting of Data Data presentation was inadequate. OR Major inconsistencies were present in reporting of results. 4940388 3041958 LXX ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** C.2.3 Fate For the screening review of LPS candidate dipropylene glycol, EPA excluded a total of 453 references when assessing environmental fate. Off-topic fate references excluded at title/abstract screening are listed in Table C. 10, and those excluded at full-text screening are listed in Table C. 11. References in Table C. 12 represent unacceptable studies based on specific data quality metrics for fate. Off-topic and unacceptable references are displayed next to the corresponding exclusion criteria. Table C.10: Off-Topic References Excluded at Initial Screening for Fate Reference excluded (HERO ID) because the reference did NOT contain information needs41 relevant to environmental fate 44187 4949033 4948959 4946621 4146480 2232444 4949089 4949005 4948895 4847997 404898 4949034 4948960 4946623 4148076 2232562 4949090 4949006 4948896 4853443 635083 4949035 4948961 4947105 4148079 2273142 4949092 4949007 4948898 4862648 744085 4949037 4948962 4947107 4168926 2292715 4949094 4949009 4948899 4909646 789593 4949039 4948963 4947108 4173202 2302957 4949095 4949010 4948900 4940595 789651 4949040 4948964 4947109 4275583 2563138 4949096 4949011 4948902 4940694 824457 4949042 4948965 4947110 4276472 2692340 4949098 4949012 4948904 4940855 926985 4949044 4948966 4947111 4339757 2824290 4949099 4949013 4948905 4941418 992939 4949045 4948967 4947113 4376725 2875983 4949100 4949015 4948906 4941419 1058389 4949046 4948968 4947114 4388064 2883990 4949102 4949016 4948909 4941420 1058433 4949047 4948969 4947115 4391261 2887419 4949103 4949017 4948911 4945941 1112905 4949049 4948970 4947130 4395587 2892020 4949104 4949018 4948912 4946061 1124442 4949051 4948971 4947131 4398518 2978028 4949105 4949020 4948913 4946132 1124901 4949052 4948972 4947132 4399866 3009070 4949106 4949021 4948914 4946133 1142139 4949053 4948974 4947135 4400649 3036268 4949108 4949022 4948915 4946147 1153582 4949054 4948975 4947136 4404349 3036587 4949109 4949023 4948916 4946178 1156301 4949055 4948977 4947137 4408404 3036785 4949110 4949024 4948918 4946179 1167387 4949056 4948978 4947138 4420372 3036899 4949111 4949026 4948919 4946180 1201159 4949058 4948979 4947140 4420932 3037885 4949112 4949027 4948920 4946188 1201176 4949060 4948980 4947141 4420947 3038211 4949113 4949028 4948921 4946189 1201178 4949061 4948981 4947155 4421954 3038973 4949116 4949029 4948922 4946190 1204953 4949063 4948982 4947156 4423539 3039406 4949117 4949030 4948923 4946191 1249186 4949064 4948983 4947159 4425601 3039551 4949118 4949031 4948925 4946193 1321888 4949065 4948984 4947160 4426820 3039791 4949119 4949032 4948926 4946194 1458307 4949066 4948985 4947161 4428638 3041935 4949120 4946380 4948927 4946210 1496934 4949067 4948986 4947175 4428838 3114932 4949121 4946387 4948928 4946247 1549118 4949068 4948988 4947177 4433785 3115961 4949122 4946408 4948930 4946257 1611582 4949070 4948989 4947182 4436364 3225794 4949123 4946410 4948931 4946258 1612753 4949071 4948990 4947185 4436864 3374286 4949126 4946419 4948932 4946259 1615034 4949072 4948991 4947189 4438060 3402924 4949128 4946506 4948933 4946263 1689217 4949074 4948992 4947201 4438415 3445046 4949129 4946513 4948934 4946322 1781960 4949075 4948993 4947202 4576534 3476490 4949130 4946538 4948935 4946324 1808388 4949076 4948994 4947203 4579583 3477473 4949132 4946547 4948936 4946329 1865871 4949078 4948995 4947204 4583202 3491334 4949134 4946614 4948938 4946359 1875316 4949080 4948996 4947224 4660346 3539276 4949135 4946615 4948940 4946360 41 Hie information needs for fate includes a list of study characteristics pertaining to the associated media and exposure pathways, associated processes, and use of controls. A complete list of the information needs is provided in Table A3 of the "Approach Document for Screening Hazard Information for Low-Priority Substances Under TSCA". These information needs helped guide the development of questions for title/abstract and full-text screening. LXXI ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** 1955931 4949081 4948997 4948885 4704876 3559324 4949138 4946617 4948942 4946361 1967450 4949082 4948998 4948886 4705492 3562800 4949140 4946619 4948943 4946374 1970619 4949083 4948999 4948887 4706833 3577212 4949141 4946620 4948944 4946375 2231679 4949084 4949000 4948890 4738360 3577235 4949142 4948952 4948946 4946376 2232056 4949085 4949001 4948891 4738993 3590105 4949149 4948953 4948947 4946377 2232422 4949086 4949002 4948892 4742957 3619406 4949150 4948954 4948948 4949157 2232425 4949087 4949003 4948893 4828940 3625221 4949152 4948955 4948949 4949158 2232427 4949088 4949004 4948894 4828943 3753956 4949153 4948956 4948950 4949159 3830898 4949156 3847436 3874693 4088550 3830342 4949154 4948958 4948951 4951181 3846566 Reference excluded (HERO ID) because the reference did NOT present quantitative environmental fate data N/A. Table C.11: Screening Questions and Off-Topic References Excluded at Full Text Screening for Fate Question Off-topic if answer is: References excluded (HERO ID) Does the reference contain information No 4940397 pertaining to a low- priority substance 4940399 candidate? 4949131 1763087 4940401 What type of source is this reference? Review article or book chapter that N/A. contains only citations to primary literature sources Is quantitative fate data presented? No N/A. Is this primarily a modeling/simulation study? Yes N/A. [Note: Select "Yes" only if there is no experimental verification] Table C.12: Data Quality Metrics and Unacceptable References Excluded at Data Quality Evaluation for Fate Data quality metric Unacceptable if: References excluded (HERO ID) Metric 1: Test Substance Identity The test substance identity or description cannot be determined from the information provided (e.g., nomenclature was unclear and CASRN or structure were not reported). OR For mixtures, the components and ratios were not characterized or did not include information that could result in a reasonable approximation of components. N/A. Metric 2: Study Controls The study did not include or report crucial control groups that consequently made the study unusable (e.g., no positive control for a biodegradation study reporting 0% removal). OR The vehicle used in the study was likely to unduly influence the study results. 4940366 4940402 4940404 Metric 3: Test Substance Stability There were problems with test substance stability, homogeneity, or preparation that had an impact on concentration or dose estimates and interfered with interpretation of study results. 4940404 4940430 LXXII ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Metric 4: Test Method Suitability The test method was not reported or not suitable for the test substance. OR The test concentrations were not reported. OR The reported test concentrations were not measured, and the nominal concentrations reported greatly exceeded the substances water solubility, which would greatly inhibit meaningful interpretation of the outcomes. 4940402 4940404 Metric 5: Testing Conditions Testing conditions were not reported, and the omission would likely have a substantial impact on study results. OR Testing conditions were not appropriate for the method (e.g., a biodegradation study at temperatures that inhibit the microorganisms). 4940366 4940402 4940404 Metric 6: System Type and Design- Partitioning Equilibrium was not established or reported, preventing meaningful interpretation of study results. OR The system type and design (e.g. static, semi-static, and flow- through; sealed, open) were not capable of appropriately maintaining substance concentrations, preventing meaningful interpretation of study results. N/A. Metric 7: Test Organism- Degradation The test organism, species, or inoculum source were not reported, preventing meaningful interpretation of the study results. 4940402 4940430 Metric 8: Test Organism- Partitioning The test organism information was not reported. OR The test organism is not routinely used and would likely prevent meaningful interpretation of the study results. N/A. Metric 9: Outcome Assessment Methodology The assessment methodology did not address or report the outcome(s) of interest. 1763085 4940402 4940404 4940388 4940389 Metric 10: Data Reporting Insufficient data were reported to evaluate the outcome of interest or to reasonably infer an outcome of interest. OR The analytical method used was not suitable for detection or quantification of the test substance. OR Data indicate that disappearance or transformation of the parent compound was likely due to some other process. N/A. Metric 11: Confounding Variables There were sources of variability and uncertainty in the measurements and statistical techniques or between study groups. 4940402 4940404 4940430 Metric 12: Verification or Plausibility of Results Reported value was completely inconsistent with reference substance data, related physical chemical properties, or otherwise implausible, suggesting that a serious study deficiency exists (identified or not). 1763085 4940366 4940402 4940404 _xx7ii ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Appendix D: Summary of Public Comments On March 21, 2019, EPA initiated the prioritization process for 20 chemical substances as candidates for designation as Low-Priority Substances. EPA published a document in the Federal Register providing the identity of the chemical substances being initiated for prioritization and a general explanation of why the Agency chose these chemical substances. EPA provided a 90-day comment period during which interested persons could submit relevant information on these chemical substances.42 For dipropylene glycol, EPA received public comment recommending that the Agency consider specific publicly available data sources. EPA reviewed all of these sources as part of its screening review of the chemical. Table 1 below lists these recommended sources, the HERO ID (if applicable), and notes about each source. EPA used the Health & Environmental Research Online (HERO) database to search, retrieve, and/or store data sources supporting scientific assessments. For references with HERO IDs, more information on the references can be found by searching the HERO ID at https://hero.epa.gov/hero/index.cfm/search/index. Table D.1: Recommended Sources for Dipropylene Glycol based on Public Comment Source HERO ID Notes The Dow Chemical Company. (2013). Product Safety Assessment: Dipropylene Glycol. NA EPA captured this information from other sources in Section 3: Physical-Chemical Properties. CIR (2006). Annual Review of Cosmetic Ingredient Safety Assessments- 2004/2005. International Journal of Toxicology, 25(Suppl 2), 1-89. 5021883 This article was part of EPA's literature review process. It includes concentrations of dipropylene glycol and other chemicals in cosmetics and other products, which are not in TSCA's regulatory scope. CIR (1985). Final Report on the Safety Assessment of Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol. Journal of the American College of Toxicology, 4(5), 223- 248 4941420 This article was part of EPA's literature review process but was excluded due to limited data reported in the summaries. Fowles, J. R., Banton, M. I., & Pottenger, L. H. (2013). A toxicological review of propylene glycols. Critical reviews in toxicology, 43(4), 363-390. 3038211 This is a review article that contains citations to other literature sources, which EPA consulted but excluded because it only contains citations to primary literature sources. West, R., Banton, M., Hu, J., & Klapacz, J. (2014). The Distribution, Fate, and Effects of Propylene Glycol Substances in the Environment. Reviews of Environmental Contamination and Toxicology Volume 232. Springer, Cham, 2014. 107-138. 2537482 This is a review article that contains citations to other literature sources, which EPA consulted. Haque T, Rahman KM, Thurston DE, Hadgraft J, Lane ME. (2017). Topical delivery of anthramycin I. Influence of neat solvents. European journal of pharmaceutical sciences. 104:188-195. 4947114 This article was part of EPA's literature review process but was excluded because the reference did not contain information pertaining to the low- priority substance candidate 42 Docket number EPA-HQ-OPPT-2019-0131 includes the list of 20 chemical substances that are candidates for designation as Low-Priority Substances for risk evaluation ("https://www.federalregister.gOv/documents/2019/03/21/2019-05404/initiation-of- prioritization-under-the-toxic-substances-control-act-tsca). Individual dockets were established for each of the 20 low-priority candidates. Docket number EPA-HQ-OPPT-2019-0124 addresses dipropylene glycol. LXXIV ------- *** Proposal Draft - Do Not Cite, Quote or Release During the Review*** Table D.1: Recommended Sources for Dipropylene Glycol based on Public Comment Source HERO ID Notes US EPA Exposure Predictions (mg/kg bw/day) for Dipropylene glycol (CAS No. 25265-71-8) / DTXSID0027856 from EPA CompTox Chemicals Dashboard. NA This source was not used because it contains predicted exposure data. High Throughput Heuristics for Prioritizing Human Exposure to Environmental Chemicals" Environ. Sci. Technol. 2014, 48(21):12760-12767. 3841221 This article was part of EPA's literature review process. It was excluded because it includes predicted exposure data. EU REACH and ECHAdatasets NA EPA reviewed and included information in Section 4: Relevant Assessment History. Environment Canada NA EPA reviewed and included information in Section 4: Relevant Assessment History. OECD SIDS Initial Assessment NA EPA reviewed and included information in Section 4: Relevant Assessment History. Safer Choice Chemical List (SCIL) NA EPA reviewed and included information in Section 4: Relevant Assessment History. LXXV ------- |