PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
S-EPA
United States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Risk Evaluation for
N-Methylpyrrolidone
Systematic Review Supplemental File:
Data Quality Evaluation of Ecological Hazard Studies
CASRN: 872-50-4
October 2019

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
NOTE: EPA is still addressing comments for the metrics and any upgrading/downgrading of studies
based on the reviewers professional judgement.
1

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
O
CM
CO
CM
CM
05
CM
CM
«
CO
+=>
Ch
a;
+=>
Ph
o
O
o
Jh S3
^ 2
JS £
s -5
¦ s
£ §
>>o
.*	S3
"S	0
TO	S-l
+3	4-h
P	o
<	-n
^ -73
O S
2 PQ
S3
3
ai
H
c6
S3
bO
c6
s
•3 K
S3 ci
H C5
<¦£ w
bO Q* '
S3 c8 £?
S3
a)
PU
d
t-i ci3 £?
a) 05
&H Q "
co
o
o
K
• ^ a
O 	^
S3	bO
O	O
^ S3	^
§ is	•
— 'x
O o
t H
-O
S3
a
S3
£
o
<
fa
w
<
PQ
o
S3
>>
T3
S3
bJj
O
£
cfi
a
O
C
fa
O)

o
o
CJ>
o
o






S-l
S-H
S-i
S-l
S-l
S-l
O
0
0
0
0
0
"c6
"c6
"c6
"c6
"c6
"c6
0
0
0
0
0
0
-O
-O
-O
-O
-O
-O
c6
c6
c6
c6
c6
ci3
J
i-J
J
J
i-J
J






bJj
bJj
bJj
bJj
bJj
bJj
^O
^0
^0
^0
^0
^0
0
0
0
0
0
0
2
2
2
2
2
2
'3
'3
'3
'3
'3
'3
o
o
o
o
o
o
Eh
Eh
Eh
Eh
Eh
Eh
.2
.2
.2
.2
.2
.2
+3
+3
4-1
4-1
+3
+3
c6
c6
ci3
ci3
c6
ci3
S3
S3
S3
S3
S3
S3
cr
cr
cr
cr
cr
cr

<

<
<
<
ci
ci
ci
ci
ci
ci
0-
0-
0-
0-
0-
t-
C5
C5
C5
C5
C5
C5
1—1
1—1
1—1
1—1
1—1
1-1

fc
fc
fc
fc
fc
C
C
C
C
C
<
O
O
O
O
O
O
-O
S3
a
S3
S3
bJj
O
T3
S3
ci3
bJj
O
CJ
'tt
£
Oh
X I
H '
c<3 o
d -§
^ T3
fa T3
co a)
,
Eh
ci3
Q
a3
S3
cr
C
S3
O
^3
03
S3
cr
<
S3
O
03
S3
cr
c
S3
o
JS
c6
S3
cr
< ~
*3
~.S
S3 bO
2 *G
-=3 o
co
O
.2 |
1 §
cr .5
C £
TJ
03 '
s-i a)
3 ¦
0 "S
-<3
05 fa
a
a3
.Q
fa
1 -a
a
a)
! S
a) tJ
.i=i
o &
u bo
•I!
ii
< ^
S3
AZ. O
< £ Co-
•S	I
§	I
"B	P^
in	^ ®
C	^ S3
'S
c3 P

O
c z
C6
S3
cr
C
ci3
T3
A $
+=
.a 2
fl -O
o a)
f-i -p
O >
c6
S3
cr
<
S3
O
S3
O
c
o
Ph
ffi o
HH hH
O
05
O
oo
00
00
00
00
00
Oi
o
l>
rH

oo
00
00
00
00
00
00
o
00
kC
kC
o
o
o
o
o
o
o
o
05
05
05
05
05
05
05
Oi
Oi
Oi
Oi
CO
kC
LO
l>
l>
l>
l>
b-
l>
l>
l>
LO


o
o
o
o
o
o
o
o
CO


kO
LO
kO
LO
LO
kO
LO
kO

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
s

o

fH

'£

s

H

<¦1—1
O

.3



CD



2

CQ

c6

S

bfj

G$
g

ed

'3



ft

&

Q

o



CD

s

O

.3

3



o

fH

—



ft

CN







4^

CD
3



44-H
O





'o

'x

o



CJ



"cl

S

C
t-
c3
Oi
CD
CO
"3
CN
a
Ci
c
CO

CO

t-
o

o
b£)
CN
^O

o
d
o
2
'x
o
CO
H

T?
E-i
s

a3
b5
S
S
o
CD


a3

.3
3
d
G$
4^

S
3
O
a3
O
J



ffi
"S

CD
O
3
o
3
<
0
S 2°
01
g CO
Z* *0
<< CO
ft ..
H 0
c3 O
te cd
Q K
Ph .ij
S <
^ rrt
-a .fap
H co
CN i—l i—l
XX X



bi3
bi3
bi3
s
s
s
s b
^ s
2	m
a) a)
CJ CJ
fl S
a3 c3
-4-3 -M
cc cc
& &
3	3
CO CO
-m -m
cc cc
$ $
$
s
a
o
Q
1—1
CN
CO

O
o



-m
-M
-M
CD
CD
CD



=0 §•
>> p
(D T3
T3 C
3 O ¦
£ g

CN
X
CD
s
O
o
C3
bj)
0)
£
S .2
bO a)
'53 5
a) >R '
(D
^3
a a
^3
H
* -c
H
£
o
J
s
o
ft
CQ
CD
S
O
o
a3
bj)
CD
£
c >>
bO T3
, "53 3
a; c£
;5 H
£
O
J
<
CD
o
T5
s
ct
2? -* ^ 5
(D t3 '
£3  n
c c
(D (D
P-h ^ '
, £ £8 ,
Oh
O Oh g ;
CD S CX '
O ^ O «
^ ^ 43 i
®T3 4
V 3 £
fl O 3
•2^ fl-
J !
J' P f
= B '
3 S'c (1) > O 2
c





a
0
(D

"m
_0





(D
S
Oh
0
(D
Oh
^3
H
13

CJ
Qj
S

(D
5
^3
CJ
CN
X
G$
d
S
c$
ft
CD
H
CO
s
CD
S	*E
O	CD
*¦5	ft fl
c$	* O
.N	H •£
fH
CD
C3
o
o
ft
X
H
.3
3
3
o
Q
1

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
S
O
u
s
H
44-H
O
.9
CD
3
PQ
c6
S
bJj
c3
£
ft
Q
Oh

o

t-
c3
Oi
CD
CO
"3
CN
a
Oi
<
CO

CO

t-
o

o
b£)
CN


O
d
o
2
'x
o
CO
H

T?
E-i
fl

a3
bJ3
£
S
o
CD


+j
a5

.9
9
d
a5
4^

S

o
G$
o
J



ffi
"S

CD
d
9
o
£
3
C
o
S 2°
g CO
z* *0
<1 CO
ft ..
H 0
<£ O
te a)
Q ffi
2	o
>	"S
s a
?«§
3	gw
>	2 |
5 bO ^
3  jg	<&
) •	3
"3 73 •
fi
S ^
TO M
CD
^ (D
3
O
bO
& C
£ * £
T3 CD g
>» 2
* S
£ 3
P Q ^ o ^ p;
•-1	(D
(D	fl
(D	CD
js	b
H	g
O
J
TJ
C
o
ft
X
H
44-H
O
s
o
o
(D T3
* 'EL
C £
0 ^
u Tj
O pL,
*S
H £
c3
d
S
S
CD
a
S
O
O
CO
£
a3
CD
(D -£
H §
CN
X
bj)
2
a"
CD
£
T?
s
a3
S
O
£
Q
o
ft
X
H
jD jD
'H.'cS
I ^ •-
bO §
o a1
£ C
w "3
fi '>
O O
"g &H
fi o
(D C
8 ^
^ s -
52 c
*.S|
B p° §
O s
so ®;
^ 1—' ^
£¦§ s.
"3 0
CD _£
bO o
C 3
2 S
CL-
IO
a2
x 'z
ni *-*
$ c ro m
n £ ^ '
Oh^ £ i
® c H i
^ -3 '4
Hi gc« J
^ t 2
£ a; 8 ;
E-1 D. hCi
^ CN >
5 ^
2 ^ 0) -
(D ""15
-a to o
+= o
^ tS °
5 o
^ Dh
C ^ '
8 'S ¦
! ^ H J
£
O
J
X
H
b£)
.9
'a
a5
ft
CO
CB
ft
£
O
fH
o
o
ft
X
H
£
izi
bi3
2

o
CO
'a?
CQ
bi3

S S .
ifi
^ O o
Q
(D n jS
5 ^ ^
J .b
£ ^
(D
-2 ^
T( ®
™ TJ
(D .S
1°.
S-g .
® B
(D _g
(D T3
^ £ "
S.1I-B b0
a-s| § I
® 3	k	§
s	o > CD	O	C •
2 bO 73
fH t c
r O ti
CN
X
T5
CD
c3
o
£
G$
bi3
fH
o
£
S +e
cs ^
o

.9
S
9
o
Q
(X O 1
B & :
^ Hi 1
' ^> ~V, > .
0h (D
o
O C
CO15
.2 ^ c
-4-=> Oh 03
fl
0 fl C TJ tfi
03 g ¦
+5 3
T?
CD
s
.2
s
o
O
s
CD
"0
S
a3
S
O
c
2

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
S
O
u
s
H
44-H
O
.9
CD
3
PQ
c6
S
bO
c3
£
ft
Q
Oh

o
<3 £r
Ci
0) CO
4^ I
£ CN
c
O
o
H
&£
s
CD
d
&
G$
J
ffi
d
o
3
«	&
r-
^ £
bj) _o
O	a)
o	M
o	53
'S	£
H	~
T5	.y
§	%
n	^
.2	<
"§	^
s	^
*3	£
9	2
CS
£	X
o	^
O
r> o
S 2°
oi
g CO
3 *o
<1 CO
ft ..
H 0
c3 O
te a)
Q K
-1 S (D +3 ^
; 5 u ^ S
¦ " o o ?
xT <6
o T3
(D o
, TS
) = +3 5) £
§ C §
o!
&. B n;
s	X	m	a3
7	(D	n3 (D	o
1	u	(D (->	^
-	(D	£ (D
2	.£ £
I B I | £
rst^I
s a«| s
i0 ° £ QH'--
^ £\s.a
> x u p 3 ;
4 (D	>	¦
) +» Oh p ® :
3^-11
i .s:K11
Its ^ g £? :
< (D £ .o o ;
o ^
Sh >
^ C-1
J3 £
H 2 .
fi T3 .
C •
H
o
J
ft
CD
s
c3
£
G$
bi3
fH
o
_o ft
1	°
2	M
£ O
''fl T3 :
i -a
! H .
\ % x .
i ^.2 o '
j ^
! n ^ (D
: S ^ !2 .
n 05 .5 3
(D <]- .
bO
*S &,X! c3 Oh-
C O <1>
^ 0
'fl
O bC
j c
1 -3
» = i
^ B '3
m .3
S
^ I0'
bO O •
O a
O u
J O » '
£ U (D
?	TS •
O "5
03
ft
CD
a
a
&
S
S
.2
s
o
o

a5
£
a"
CD
C
^ a t3
C 3
(D ®
g 0
S «
(D ^
£ a>
-a o 3 ^
H a O £
CN
X
G$
d
S
bi3
o
TJ
o
CD
£
O
c
CD
£
o
o
Q
G$
d
S
CD
£
o
44-H
O
CJ
S
S
O
o
J, o TS
n3 5
CD CD CO
+5 3 c
-'S ^
H
CN
X
a5
d
S
T5
S
ai
S
b£)
e5
g
bJO
.9
s
s -
cS
£
o
O (
o
Q
!> ci
bJ3 •
.9
^ L
£ r
£
<8
s
o
O
a
T3
H
a5
a5
S
O
ft
X
H
T5
CD
s
£
O
O 1 ®
" o g ^
S ° 'S S
^ a
m .- o c
•S ^ &H.S
o3 O ^
^ C
(D (D
> T3
® MO Q,
® | K ^
^	-S
X!	rH
S 2 §
, bp
H -o £ .S
o
J
T5
o
^ g
fl cc
T?
S
03
S
.2
"§
s
o5
"§
Q
o
Q
3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
S
O
u
s
H
44-H
O
.9
CD
3
PQ
c6
S
bO
c3
£
ft
Q
Oh

o
<3 £r
Ci
0) CO
4^ I
£ CN
c
O
o
^ 2
fcuO _o
O a)
o M
.o S>
H
b£
S
CD
d
d
G$
J
ffi
d
o
3
T5
S •,
a3 ^
£
O"
C
3
O
c> o
t"~-
S 2°
T* Oi
g CO
<1 CO
ft ..
H 0
<3 o
te a)
Q K
S CD C
«2 ^ "3
-0 ^
(D • CN
n S*"0
O ^ tp
&, o -*±
(D u o3
u bO^
0 0^
Oh CS
(D ,-£
a ^
<
H
Q
M H
3
c o
o -a
CN
X
C3
a3
S
a3
"§
Q
bj)
£
O
ft
CD
; (d ^
1 w
a3
ft
CD
a
a
c$
S
£
o
CD
ft
X
CD
s
S
.2
a3
S
ag
X
H
Q
£
a
o
TJ
CD
H
2
'
t-H CO
5 '£
?»		S <-
o	a) co
c3
-a
TO	c
Oh ^
CO •—'
O o u Js
¦« 4J -P T^
<3 >>
u 73
"2 S3
& «
^.8
t-l 4^
3
0 s=5
5 s
o
0 r«3	K
2 fe	fe
TO	«
S
s
a)
fl T3
a) —«

T3 i^h -
-2 ^
-Q
c3
c3
£3
£>
C
c3
I
"S
z >¦.
c3
^ S
" ^
a) ft
S H
c3
r*l
a U
a) c6
o co
O CO
S 8
.H a)
fl
T3
S3
S3
O
W
w
T3

o
bJO
s I i S11
.•	cd
^ M	8-1
§ 11 ii	s
cB &h	o
tH ^ ^3
¦ - a> s
»Skh
bJO
S3
c3
g
*5)
bJO
S3
c3
J3
T3
T3
c3
S3
CT
O
S3
>>
c3
s
T3
S3
c3
>;
T3
S3
a
>,
co
VI
0
4J
co
01
Al
&
0
J
co"
01
V
o
a
x
a)
a)
o
S3
a)
TJ
«C
S3
o
o
.Sf
S-i
«s
c3
.	a)
t- bJD	+=
• S3	u
^	o
Al g	_g
a I:
.3 a	s
TJ OJ	®
OJ S	.
5 ~	-a
^ o	•£?
K
3	"
¦	0)
K 4^
i-H °?
V o	s
° a g
T—I ^	 9	'G
S—I TO	4J
"§ 3	S
So
4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
00
fcuO
C
CO
00
o
£
2
-3	^
U	CB
^	E
 Ci
i—I
„ _g lO
ra S oi
<1 § ^
m c ^
s
.2
*-1-3 ..
as a)
ft
° H0
^ o
J +"? fH
r, c$ a)
co Q ffi
bj)
2
CO
H
CJ
a)
a
S
a3
CO
H
.s
s
s
o
Q
,G -G
H H
> ^
I .SP
J K
g >»
o ^
CO Ph
fl S
a3 a3
2	3
CO	CO
-m	-m
cc	cc
£	£
CN CO
o
d) d)
u u	(_,	"£
CD CD	CD	S
^ ,£3	^	Oh
H H	H	£
^ ^ >
fcuO fcuO g
SS j
Ph ^
e^H ,—i o
O O ^
fH fH P~1
O O TJ
O O g
g s a
o
C3 C3 32
bj) fcuO rt
cd cd c3
£ £

lO
CO
o
o
o



-M
-m
-M
CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
£ (D
£ O"1
^ .s
G ^
G a)
-0 £
§ £
rH ^
s ^
£ CD
S® (D
£ £
a .2
"S ^
G (D
(D d •
a s t
'£ M °
CD CD ft
Oh +» g
(D O 
-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
00
fcuO
C
CO
00
o
£
2
c3
T5

3
ft
CO
00
01
i—I
d
<
CO
C
2
o
CO
Ci
2^ Ci
i—I
-2 S
"K Ci
g io
Jh
PQ C §
s
.2
..
c3 CD
ft
° Eh 0
<-3 c$ o
J +"? fH
co Q ffi
(D ^3
N C
H :
bj)
2
s
.2
^3
s
o
O
s
ai
S
O
C
-d

fl

a3

J

bO

S

o



0

"o



c

0

o

(D
fl
j"
0
bO

s
£
O
o
4^
lO
3
^0


a3
a?

"S

o

'Hh
t
(D

^ rr>
(D
s s
a.1
S H
&
o
J
CD
ft
T5
5
6
S
c3
bO
.5 ^
-3 ^
T3 jj1
C (D
O t!
3 ^
O (D '
A £i
'fl ^ "£
S3- CD CD
o £
bi3
2
s
.2
^3
s
o
O
O H
o
a
c$
ft 3
2 a*
O £
M TJ
cd
|
£ O > 1
-o !
i ^ :
HS.
bO
ffi ffi
c
2
o
fl
o
O

(D CD
"£ C
bj)
2
s
ai
S
*53
a)
Q
H
*M
!>
__ bO
O .3
£ TJ
o
O
cd
g -§
0	cd
1	1 o
s °
¦ ¦ O fH
I U Ph
¦> ••
K> Ci
bO •
.s ¦
^3 I.
S r
3
cS
s
o
O
.s
s
s
o
Q
£P ^
o *
o c
ex o
bi3
2
o
ft
X
H
s
2
O
o
CN
M 3
ho o :
.s a c
; t3 ^
' c
3 C £
rn tl) r1
.5
H fo
b£)
T5
O
^ o
fl CO
^ «
CO
o3
S
O
c$
"§
Q
.3
3
3
o
Q
b£)
ffi ffi
o5
Q
bi3
o
ft
CD
H
bi3
2
o
T5

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
00
fcuO
C
CO
00
o
£
2
c3
T5

3
ft
S C
£ _
• 'Th
CO £
00 O
o
<
CO
c
CO
CI
2^ Ci
i—I
-2 S
"K Ci
g io
Jh
PQ C §
s


.2





a3
a)


Oh

G
H
Q
TJ
c$
o
3
4^
CO
"c3
Q
fH
a)
K
a)
Ch ^
s ffi
-Q
c3
c3
S3
£
>>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£ >»
c3
^ S
" ^
<1) Ph
3 a
"£? r*>
CIh ^
d> C6
o co
O CO

o
T3 t»
d) TO
c3
n ' ' f-i
,, <0
>
fa " O
& 3^
H
bO
S3
CO
VI
o
4^
CO
c4
Al
£
0
J
co
01
V .
Al
s
.2
-3
a)
c3
S3
.2
;+=
-3
T3
c3
S3
CT
>>
c3
s
T3
S3
c3
>;
T3
S3
a
>>
o
(1)
a
x

-a
.Sf
. 2
0	n
1	o
! ^
I .2h
'£
0
(1)
s
2 I A
&•£?
b. K
^ P —i
V d a;
P s 3
All	^
1,3	IS
"	TO
+=>	_d
bo 3	+3
ffi 0	m
tj	a
0 0	*S_i
S-l CO	+3
D M	d)
-a o	^
s s	s
7

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
&
s
Oh
S
3
00
01

O
00
CN
O
s
3
bj)
O
£

CD  ^
I .SP
J K
g >>
o $
CO Ph
fl S
C3 C3
2	3
CO	CO
-m
CO	CO
$	$

CN
CO
O
O
o






CD
CD
CD



u U	(_,	"£
CD CD	CD	S
^ ,£3	^	Oh
H H	H	£
^ ^ >
fcuO fcuO g
SS j
Ph ^
e^H ,—I O
o o 1=3
fH fH '"I
O O TJ
O O g
g £ a
o
c3 G$ T3
bj) fcuO Ph
cd cd c3
£ £
S £
bO a)
H
.9
3
9
o
Q
2
n
£ (D
£ a"
^ .s
fl ^
d a)
§ £
rH ^
s ^
£ CD
S® (D
5? £
^ .2
"S ^
C (D
(D d •
a s t
'£ M °
CD CD ft
Oh +» g
(D O >
§6	£|
U T-l	(D
—1 s	"2	^
a	|
•d CO	O	03
S ^ °	m
2	Hh	¦**	c •
C n	O	O n
m ^	fl C
05 g	M	g .2
¦J O	»	C s
_2 ^	°	(D
t, p	C	u d
o	c3	C (D
) ^
3
5 tu
fl "d
2 u
^ crt
(D ^
bo IX °
d Oh
• £ CD -C
" * a
! ffl 1
"ge
rS £ -^
r u iS •
& ^
(D (D
3 £
T3 TS g
(D O
(D tn ^
^ O ^
E-1 &, as
9. <0 -rt
P ° Z
hi
(D 5 ^
£ 0 ^
H Oh O
Oh
CD
£
CO
s

.2
CD
*-(-5
Oh
o3
X
•N
H


CD

-M

a

c$
fH

&
.2
o
fH
CD
CD
f-H
S
s

CO

O

Oh

X

H

6i

.9

S
d

n
o

Q

fl
s
TJ
C
o
Oh
X
H
fl
o
O
s
o
O
s
cd
CB
CO
H
s
CD
O"
T5
S
o3
S
O
0
Q
o
Oh
X
H
b£)
.9
'o
05
Oh
CO
CB
Oh
3
O
fH
o
o
Oh
X
H -
CD
&
J

s|
C ^
O £2
Oh d
X ' •
H
CN

1—1
CN
1—1
i—i
X
X
X
X
X
X
bi3
bi3
s
.9
^3
CD
bi3
bi3
bi3
s
s
§
s
s
£
a3
fH
a3

a3
fH
¦s

X
H

J
&
£
o
CO
'a?
CQ
fcuO
s
H
8

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
&
0
Oh
S
0
00
01
&
r0
O
00
CN
O
s
3
t*")
bO
o
a
*X
£
q-H _C!
O GG
5	E
a -M
% I
6	%
CD 
^3
s
o
O
T5
s
c3
S
o
<
£
i-i
X

£
0

c
CD

CD
N
c
CD

CD
£

O

CD
a3
"S
>
f-i
CD
CD
n3

0
^3
u
o"

0




TS


Oj
C
1
"£
.32

0
'o
.5
-3 ^
^Ei '
(D f-i
I $¦
£ T3
(D &i o
"> tl

£
fH CX
IS


d c
u
CD
C
§.2
'o5
s
CD
^3
3 S
'o
CO
H
0 S
u
^ &
C (D
O x!
3 ^
O (D '
^ ,Q
"c ^ m
S3- CD CD
O £
o
J
CD
ft
T5
0
C3
S
C3
bO
fH
o
CD
0 M
£ O
bj)
2
s
.2
^3
s
o
O
H
44-H
O
CJ
C3
0
a"
CD
c
CD CD
i s
CD (D
£ .s
bO
bj)
o
TJ
o
C
0
o
.s
s
s
o
Q
<
CD
s
O
a
-m
0
o
! >> 1
T3 !
i ^ :
HS.
bO
ffi ffi
c
2
o
0
o
O

(D CD
"£ C
bj)
2
s
a3
S
'53
CD
Q
H
*M
£
__ bO
O .3
£ TJ
o
O
CD
a
O CD
' ' O
3 °
¦ ¦ O fH
I U Ph
¦> ••
K> Oi
b£) •
.5 ¦
^ i.
s r
cS
s
o
O
.S
s
s
o
Q
£P ^
o ><
o c
ex o
bi3
2
o
ft
X
H
s
O
o
CN
M 3
bo o :
.s a c
; t3 ^
' c
3 c g
rn tl) r1
.5
H fo
b£)
O
^ o
ri
m rn
s
o3
S
O
c3
4^
CO
c$
"§
Q
.3
3
3
o
Q
b£)
ffi ffi
o5
Q
bi3
o
Oh
CD
H
bi3
2
0
o
,;D
Oh
X
CD
s
S
.2
*+^
o3
S
og
u
x
H

CN
CO
CN
CN
CN
.2
.2
.2
*M
*M
*M

4^

CD
CD
CD



bi3
2

CD
bjo
cd
a
+3
X
CD
fl
a
o
T3
CD
S
.S
*4J
fl
o
O
CD
Q
CC
0
a
o
X
H
9

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
&
s
Oh
S
3
00
01
&
r0
O
00
CN
O
s
3
bj)
O
£
a -B
% i
ft _5f
d) >
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^
<1)	Oh
3	a

CIh ^
d>	C6
o	co
O	CO

o
T3 t»
d) TO
c3
n ' ' f-i
,, ^
>
fa " 0
& 3^
H
bO
S3
CO
VI
o
4^
CO
c4
Al
£
0
J
co"
01
V .
Al
s
.2
-3
a)
c3
S3
.2
;+=
-3
T3
c3
S3
CT
>>
c3
s
T3
S3
c3
>;
T3
S3
a
>>
o
(1)
a
x

-a
.Sf
. 2
0	n
1	o
! ^
I .2h
'£
0
(1)
s
2 I A
&•£?
b. K
^ P —i
V d a;
P s 3
All	^
1,3	IS
"	TO
+=>	_d
bo 3	+3
ffi 0	m
tj	a
0 0	*S_i
S-l CO	+3
D M	d)
-a o	^
s s	s
10

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
o
5?
« .5
£ m
4^ fH
S O
o ^
u ft
^ Q
o ^
O §
-s £
CD
bO +e
O o
'O o
c3
2
o"
c
• CO
s o>
Ci o
c3
2
o"
c
'ms
o
. d)
% 2.
o ^ S
00
00
0
01
t~
o
s
.2
..
c3 CD
&
° En 0
^ o
J +"? fH
£ <$ CD
co Q ffi
S
S
o
O
c3
Q
fo
C
0
"2
'>
2 G
-G o
H £
bO bj)
2 2
o
CO
fl	s
c3	c3
-4-3	-M
CO	CO
CO	CO
-M	-M
CO	CO
$	$
d) i—I	CSI
S -g	-g
c6
i® -M	-M
-g S	S
CO
H
.s
s
s
o
Q
H
TS
a,1
t,
0
G
Oh

(D



(D
h?

bO

a
3
O
'&
v—/

"o
'o
i~>
f-i
G
G
0
0
CJ
CJ

fcuO fcuO g
2 2 j
CB

O
o
fH
fH
s
S
o
O
O
o


.£;
.£;


03
03
b£)
b£)
CD
CD
IZi

c

lO
CO
o
o
o



-M
-m
-M
CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
^ (D
£ a-
ZH
rZ .g
a ^
g o
-o £
§ £
rH ^
s ^
£ CD
S® (D
5? £
a .s
"S ^
G (D
(D d •
as t
'£ M °
CD CD ^
fV +3 P
Oh
X
(D
(D
-G
H :
O tD
a;

G

0

Oh

X

(D

T3

G

a3
Oh

G
T3
0
-0;


bO
0

OhT3
(D
G
u


(D
*
-G
G
w
0
0
"S
CJ
s
a3
0
G

S
*
(D
G
G
0

CJ
0
Oh
(D
X
(D
H

i	OS X!
G i	(D '
O O C
O i—I (D '
_ R	-d :
§	§
nco o
«3 'Z
(D a
£ TS
MftJ
d o.
• G (D T$
2 -G d
"E ? G cj d
o °i fi G D
j ^
; cq r
G O \r
O £ «
° g S
Oh >,.
- n
§ 2 g
"43 cx 2
}-< a oo
3 ^
T3 T3 .
(D
(D tf ^
^ o 5
H Oh M
ft
CD

CO
s

.2
CD

ft
c$
X
•N
H


CD

-M

a

&
fH

&
.2
o
fH
-M
CD
CD
M
S
S

CO

O

ft

X

H

CO

.9

S
d

n
o

Q

fl
s
TJ
C
o
ft
X
H
s
o
O
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
0
Q
o
ft
X
H
b£)
.9
'o
05
ft
CO
CB
ft
2
o
fH
O
o
ft
X
H -
CD
&
J
£ J
^ 5 T3
O ^ §
lit
G o E
hi
D 5 p
£ 0 ^
H ao
"S
g £;
o ^
Oh G
X ' •
H
CN
i—i
i—i
CN
i—i
i—i
X
X
X
X
X
X
b£)
bi3
S
.9
^3
CD
bi3
.a
bJO
bO
2
2
§
2
2
2
a3
fH
a3

a3
fH
¦s

x
H

J
o
CO
CQ
bi3
S
H
11

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
o
5?
« .5
£ m
4^ fH
S O
o ^
u ft
^ Q
o ^
O §
-s £
CD
bO +e
O o
'O o
c3
2
o"
c
c3	'T^
5 §
<1	^
•	CO
f5	o>
2	3oo
^	00
•	CD o
fe	2 oi

S 3
(D (D
£ .£
bO
bj)
o
TJ
o
C
3
O
.s
3
3
o
Q
C
cd
s
o
a
4^
3
o
! >> !
-c f
3 -
bO
ffi ffi
c
2
o
s
o
O
^ <
(D  ••
K> Ci
b£) •
.3
^ L
r
cS
s
o
O
.3
S
3
o
Q
B
o3
'B

a
o
bO
Oh
0
X
(D
0
't
T3

(D
<2

T3

Oj
C
0

c

(D
a
(D
0

o
3

0
'cS
^3
(D

T3
n3
(D


0
0


0
C
Oh
0
(D


•£
0


"S
.3
o
ft
x
H
s
2
O
o
CN
1^
fl <$
(D
6
(D
£5 ^
> as
A 3^
H S
Oh	^
(D	X
£	§ 8
m	3 as
bD	O >
.B	bO+5
^ B
C	O 'o
<&	£ Oh
¦J	§ c
^	O (D
<3 (D
(D	C
'	o3 "'
d> .

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
o
5?
« .5
£ m
4^ fH
S O
o ^
u ft
^ Q
o ^
O §
-s £
CD
bO +e
O o
'O o
c3
2
o"
c
c3 'T^
5 §
<1 ^
•	CO
f5 o>
2 3oo
^ 00
•	<1) o
fe 2 oi
>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^

a	U
<1>	<$
o	co
O	CO

>
fa "	O
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
0
J
co"
01
V
bj)
S3
>
o
h &
c3
S3
.2
;+=
-3
T3
c3
S3
CT
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
TJ

-a
.£P
. 2
S-i
£
.2h
*£
0)
bO
S3 5-1
! a)
: ^3
Eh
Al
s
.2 ^ o
"B I s
S-gi
&•£?
b. K
** o '
V d a;
P s 3
Al"g «

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Jh
"a)
s
o
fH
Oh
(B
CD
. ^
lO
0	ft
CO §
01	S
CO x-1
iH On
J
GO
O P>
f? S
1 ^
&	,£5
0
1	Oh
O	S
"§ £
J M
cd
>> ^
bO +e
O o
'o o
a3
2
a"
C
• CO
a> oi
Ci o
a3
3
a"
C
'ms
o
. a)
s 2.
o < §
00
00
o
Ci
b-
o
s
.2
*-1-3 ..
a3 CD
Oh
° H0
^ o
J +"? fH
r, c3 cd
co Q ffi
s
S
o
O
c3
Q
fo
C
0
"2
'>
a) fi
-£ o
H £
bO bj)
2 2
o
CO
fl	s
a3	a3
-4-3	-M
CO	CO
CO	CO
-M	-M
CO	CO
$	$
d) i—I	CSI
S -g	-g
c6
i® -M	-M
-g S	S
CO
H
.s
s
s
o
Q
H
(X £
u u (_,	"£
CD CD CD	S
^ ^ ^	CX
H H H	£
^ ^ >
fcuO fcuO g
2 2 j
Ph ^
e^H ,—I O
O O ^
fH fH P~1
O O TJ
O O g
g s a
o
C3 C3 32
bj) fcuO rt
cd cd c3
£ £

lO
CO
o
o
o



-M
-M
-M
CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
^ 
^ .s
§ ^
d a)
§ £
rH ®
s ^
£ CD
S® CD
5? £
.2
"S ^
C CD
CD d •
as t
'fH M °
CD CD ^
rv +3 P
Oh
X
CD
CD
H :
O CD
0.'

3

0

Oh

X

CD

T3

d

a3
Oh


T3
0
-0;


bO
0

CXT3
CD
3



CD
*
^3
C
M
0
0
"S
CJ
S
a3
0
C

a>
"b
CD
a
3
0

u
0
Oh
CD
X
CD
H

i	OS X!
fl i CD '
O O C
cj t—i CD '
_ R 'O :
§ ^ §
h co o

¦£ > c u d
o "3 "3 fl (D
j ^
; cq r
3
5 tu
fl "d
2 5
^ crt
(D ^
><
CD

CD
CD
0


0
CX
3
.S
a
*
bO
Oh
'o
CD
d
CD
ex
^d

T3

'o
^3
d

a
w
i
CD
£
JD
T3
c
CD
'o
1)
Xi
X!

a3
T3
'x

w
a
0
o3
Oh
0
0
CD
CD
CD
bO
CD
"S
fl
£
CD
a*
3
a
& ^
CD CD
d O \r
O V ^
° «s £
" E T3
o s §
lit
fl CD 5
ia:
(D 5 o
£ 0 ^
H ao
Oh
CD
£
CO
S

.2
CD

Oh
o3
X
.N
H


CD

-M

a

&
fH

&
.2
o
fH
-M
CD
CD
f-H
S
S

CB

O

Oh

X

H

CO

.9

S
d

n
o

Q

fl
s
TJ
C
o
Oh
X
H
s
o
O
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
Q
o
Oh
X
H
b£)
.9
'o
05
Oh
CO
CB
Oh
S
O
fH
o
o
Oh
X
H -
CD
&
J
s|
C ^
o ^
Oh d
X ' •
H
CN

i—i
CN
i—i
i—i
X
X
X
X
X
X
b£)
.a
bi3
S
.9
^3
CD
bi3
bi3
bi3
2
2
§
2
2
2
a3
fH
a3

a3
fH
¦s

x
H

J
o
CO
CQ
bi3
S
H
14

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Jh
"a)
s
o
fH
Oh
CB
CD
. ^
lO
0	ft
CO §
01	S
CO x-1
iH On
J
CQ
O P>
f? S
1 ^
&	,£5
0
1	Oh
O	S
"§ £
J M
cd
>> ^
bO +e
O o
'o o
a3
3
a"
<
5 §
<1
•	CO
f5	o>
2	3oo
^	00
•	CD o
fe	2 oi
~>
CJ
a3
2
a"
CD
"0
C

m
CO
i—i
i—i
i—i
.2
.2
.2
*M
'G
'm



CD
CD
CD



(D (D
£ a>
S 3
(D (D
£ .s
bO
bi3
o
TJ
o
C
3
O
.5
3
8
o
Q
C
cd
s
o
a
4^
3
o
! >> !
-C f
3 -
b£)
ffi ffi
c
2
o
s
o
O
^ t
(D  ••
K> Ci
b£) •
.3
^ L
r
<8
s
o
O
.3
3
3
o
Q
B
o3
"S

a3
o
bO
Oh
0
X
(D
0
't
T3

(D
<2

T3

Oj
C
0

c

(D
a
(D
0

o
3

0
'cS
^3
(D

T3
n3
(D


0
0


0
C
Oh
0
(D


•£
0


"S
.3
o
a
x
H
s
O
o
CN
1^
fl ^3
(D
6
(D
£5 ^
> as
92
H S
Oh ^
(D X
£ § 8
m 3 as
bO O >
• S bO+5
S
C O 'o
<& £ Oh
¦J § c
^ O	(D
<3	(D
(D C
'	o3	"'
d> .

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Jh
"a)
s
o
fH
Oh
CB
d>
. ^
lO
o ft
M £
05 a
OO
^ Ph
J
CO
o S
£ 3
1 ^
& £
o
| Oh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
2
o"
c
c3 'T^
5 §
<1 ^
•	CO
f5 o>
2 3oo
^ 00
•	<1) o
fe 2 oi
>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^

a	U
<1>	<$
o	co
O	CO

>
fa "	O
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
0
J
co"
01
V
bj)
S3
>
o
h &
c3
S3
.2
;+=
-3
T3
c3
S3
CT
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
TJ

-a
.£P
. 2
S-i
£
.2h
*£
0)
bO
S3 5-1
! a)
: -C
Eh
Al
s
.2 ^ o
^ is
S-gi
&•£?
b. K
** o '
V d a;
P s 3
Al"g «

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
CD
s
"d
3
bi3
c3
CO
£ 3
o
1 s
£ £
s
° -9
o a
>• 3
CO Ph
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
2
C
• CO
s o>
O O
c3
2
C
'ms
o
• CD	o
fc 2	oi

2 c
-£ o
H £
bO bj)
2 2
o
CO
fl	s
c3	d
-M	-M
gg	gg
CO	CO
-M	-M
cc	cc
$	$
d) i—I	CSI
S -g	-g
c6
i® -M	-M
-g S	S
CO
H
.s
s
s
o
Q
H
Gh £
u u (_,	"£
CD CD CD	S
^ ^ ^	CX
H H H	£
^ ^ >
fcuO fcuO g
2 2 j
Ph ^
e^H ,—I O
o o 1=3
fH fH '"I
O O TJ
O O g
g £ a
o
c3 G$ T3
bj) fcuO rt
CD CD
£ £

lO
CO
o
o
o



-M
-M
-M
CD
CD
CD



H
.S
s
s
o
Q
2 'S
n
^  c u d
o "3 "3 fl (D
j ^
; cq r
3
5 tu
fl "d
2 5
^ crt
(D ^
& ^
CD CD
><
CD

CD
CD
0


0
Oh
3
.S
a
*
bO
Oh
*0
CD
d
CD
CX
^d

T3

'o
^3
d

a
w
i
CD
£
JD
T3
c
CD
'o
1)
Xi
X!

o3
T3
'x

01
o3
0
a
Oh
0
0
CD
CD
CD
bO
CD
"S
fl

CD

S


CJ1

c

CD

0

TS
0

Oh
a3
0
a
d O \r
O V ^
° «s £
" E T3
o s §
lit
fl CD 5
ia:
(D 5 o
£ 0 ^
H ao
Oh
CD
£
CO
S


.2
CD

+o
Oh
s

X
.2
•S
H




CD


-M


a


&
fH


&
.2

o
fH
-M

CD

CD
f-H
S

S


CB


O


Oh


X


H


CO


.9


S
d


n
o


Q


fl
s
TJ
C
o
ft
X
H
s
o
O
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
Q
o
Oh
X
H
b£)
.9
'o
05
Oh
CO
CB
Oh
S
O
fH
o
o
Oh
X
H -
CD
&
J
s|
C ^
o ^
Oh d
X ' •
H
CN
i—i
i—i
CN
i—i
i—i
X
X
X
X
X
X
b£)
.a
bi3
S
.9
^3
CD
bi3
bi3
bi3
2
2
§
2
2
2
a3
fH
a3

a3
fH
¦s

x
H

J
o
CO
CQ
bi3
S
H
17

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
CD
s
"d
3
bi3
c3
CO
£ 3
o
1 s
£ £
s
° -9
o a
>• 3
CO Ph
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
<
5 §
<1	^
•	CO
o>	Oi
2	3oo
^	00
•	CD o
fe	2 oi

^3
s
o
O
O H
o
a
c$
ft s
o £
M TJ
CD
|
£ O > 1
-o !
i ^ :
HS.
b£)
ffi ffi
c
2
o
fl
o
O

(D CD
"£ C
bJO
2
s
a3
S
'53
CD
Q
H
g
*M
£
__ bJO
O .3
£ TJ
o
O
CD
a
O CD
' ' O
S °
¦ ¦ O fH
I U Ph
¦> ••
K> Oi
bJO •
.s ¦
^ I.
S r
3
<8
s
o
O
.5
3
S
o
Q
B
(D
"S

a3
0
bO
Oh
0
X
(D
0
't
T3

(D
&

T3

Oj
C
0

c

(D
a
(D
0

o
"3

0
'cS
^3
(D

T3
n3
(D


0
0


0
C
Oh
0
(D


'EH
0

£
"S
.3
o
a
x
H
s
O
o
CM
fl ^3
^ <»
£ a>
Oh I
CD ^3
g § 8
m 3 aj
bO O >
• S hO+5
T3_ C
C O 'o
£ Oh
"S o c
^ o (D
X CD
D C
tH (3 +=
(Dpi)
S S|
o B B
Oh "tf CD
Ix! ^ +=
a5 £ 
-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
i—i
J
CD
s
"d
3
bi3
c3
CO
£ 3
o
1 s
£ £
s
° -9
o a
>• 3
CO Ph
O S
"§ £
J M
CD
&
bO +e
O o
'O o
c3
<
5 §
<1	^
•	CO
o>	Oi
2	3oo
^	00
•	CD o
fe	2 oi

>>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^

CIh	^
<1>	C6
o	co
O	CO

fa "	0
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
0
J
co"
01
V ¦
bj)
S3
>
o
Eh
h &
c3
S3
.2
;+=
-3
T3
c3
S3
CT
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
TJ

-a
.Sf
. 'JB
S-i
£
.2h
*£

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
^ v>
I—I 0
. CB
o ^
£ ft
03 2
fH
tn ^
§ i
° 3
sT ^
o°
I Oh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
2
o"
c
• CO
s o>
Ci o
c3
2
o"
c
o
. d)
% 2.
o ^ S
00
00
0
01
t~
o
s
.2
..
c3 CD
&
° En 0
^ o
J +"? fH
L ^ 1)
co Q ffi
S
S
o
O
c3
Q
fo
C
o
"2
'>
2 c
-£ o
H V
bO bj)
2 2
o
CO
fl	s
c3	d
-M	-M
cc	cc
3	3
CO	CO
-M	-M
cc	cc
$	$
d) i—I	CSI
S -g	-g
c6
i® -M	-M
-g S	S
CO
H
.s
s
s
o
Q
H
Oh £
u u (_,	"£
CD CD CD	S
^ ^ ^	CX
H H H	£
^ ^ >
fcuO fcuO g
2 2 j
Ph ^
e^H ,—I O
o o 1=3
fH fH '"I
O O TJ
O O g
g £ a
o
c3 G$ T3
bj) fcuO rt
cd cd c3
£ £

lO
CO
o
o
o



-m
-M
-M
CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
^ 
^ .s
§ ^
d a)
§ £
rH ®
s ^
£ CD
S® CD
5? £
.2
"S ^
C CD
CD d •
as t
'£ M °
CD CD ft
rv +3 P
Oh
X
CD
CD
H :
O CD
0.'

3

0

Oh

X

CD

T3

d

o3
Oh


T3
0
-0;


bO
0

OhT3
CD
3



CD
*
^3
c
VI
0
0
"ti
CJ
S
o3
0
C

S
's
CD
C
3
0

u
0
Oh
CD
X
CD
H

i	OS X!
fl i CD '
O O C
cj t—i CD '
_ R 'O :
§ ^ §
h co o

:•&
3
CD ^
3 u
cr as
bO Oh O
d Oh
• !3 CD TS
" ^ fi
"£ > C u d
o "3 "3 fl (D
j ^
; cq r
d o \r
° g S
>
CD CD
Oh ^
(XTS
ft
CD
£
CO
ft s
d
O
o
ft
X
H
CO
.3
S
s
o
Q
c
S
TJ
C
o
ft
X
H
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
0
Q
o
ft
b£)
.9
'o
03
ft
CO
CB
ft
S
O
fH
o
o
ft
X
H -
CD
0
J
£ J
^ 53 T3
O ^ §
lit
fl CD 5
ia:
(D 5 o
£ 0 ^
H ao
"S
c ^
o ^
Oh d
X ' •
H
CN

i—i
CN
i—i
i—i
X
X
X
X
X
X
b£)
bi3
S
.9
^3
CD
A
bi3
bi3
bi3
2
2
§
2
2
2
o3
fH
03

o3
fH
¦s

x
H

J
£>
£
O
CO
CQ
bi3
S
H
o

H
2: a
H



o
i—l
CN

00
ci
1—1
i—l
i—l
o
o
o
o
O
O

*Eh

*Sh
*Sh
*Sh
CD
CD
CD
CD
CD
CD






20

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
^ v>
I—I 0
. CB
o ^
£ ft
03 2
fH
tn ^
§ i
° 3
sT ^
o°
I Oh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
2
o"
c
c3 'T^
5 §
<1 ^
•	CO
f5 o>
2 3oo
^ 00
•	<1) o
fe 2 oi

S 3
(D (D
£ .£
bO
b{)
o
TJ
o
C
3
O
.s
3
3
o
Q
C
a>
s
o
a
4^
3
o
! >> !
-c f
3 -
bO
ffi ffi
c
2
o
s
o
O
^ <
(D  ••
K> Ci
b£) •
.3
^ L
r
cS
s
o
O
.3
S
3
o
Q
£P ^
o *
o c
ex o
.3
O
ft
X
H
s
O
o
CN
1^
fl ^3
 as
H S
Oh ^
(D	X
£	§	8
m	3	as
bO O	>
.B	b0-£
C	O	'o
<&	£	Oh
¦J	§	c
^	O	(D
<3	(D
(D	C
'	o3	"'
T5
o
^ s
m rn
c
T5
s
o3
S
O
o3
4^
CO
c$
"§
Q
.3
3
3
o
Q
c S
(D "3
S £
a;
3
o
Oh
s<;	w +j
a;	a; a;
^ T!
«2 -2
n-i	U i-
^	03 ^
15	(1) +j
"S	fH §
Q £ &
c3
Q
bi3
o
ft
a)
a
H Oh
.a
pS^

bi3
bi3
bi3
2
2
2
0
o
T5
ft
X

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
Oi
CO
^ v>
I—I 0
. CB
o ^
£ ft
03 2
fH
tn ^
§ i
° 3
sT ^
o°
I Oh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
2
o"
c
<	£
•	CO
f5	o>
2	3oo
^	00
•	<1)	o
fe	2	oi
>
S3
c3
O >>
S3 <8
co P
5s r3
-S3 03
=11
£ >»
c3
^ S
" ^
d) Ph
2 a

a	U
<1>	<$
CJ	03
O	CO

o
" £ bO
> ^ *S
3 -g t§
c3
II ,, <1>
>
fa " 0
|3.S
S ffi
Eh
bO
S3
CO
VI
o
4^
CO
c4
Al
'i
0
J
co
01
V
h &
c3
S3
.2
;+=
-3
TJ
c3
S3
cr
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
T3

-a
.Sf
. 'JB
S-i
£
.2h
*£
0)
bO
S3 5-1
! a)
: -C
Al
s
.2 ^ o
^ is
S-gi
&•£?
b. K
** o '
V d a;
° S ts
Al"g	«

d) w	a)
-a o	^
s s	s
22

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
d
U
S *
O
CO 0)
Ci ft
CO O
J g
Oh
d o
-4-3 v^
^ rr

T5
• 3
c$ Qh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
3
O"
C
• CO
s o>
Ci o
C3
3
o"
c
'ms
o
. d)
5 3.
o <: §
00
00
o
Ci
b-
o
s
.2
'-4-3 ..
c3 CD
Ph
° H0
^ o
J +"? fH
L ^ (D
co Q ffi
S
S
o
O
c3
Q
fo
C
0
-o
'>
2 g
-G o
H £
bX) bi3
2 £
o
CO
fl s
c3 c3
-4-3 -4-3
CO CO
CO CO
-4-3 -4-3
CO CO
$ $
d) i—I	CSI
8 -g	-g
c6
i® -M	-M
-g S	S
CO
H
.s
s
s
o
Q
H
(X £
u u (_,	"£
CD CD CD	S
^ ^ ^	CX
H H H	£
P^H -=H i.
M M g
K S J
fl
o
O O
X	g
o	^
M	j
3	^
O	T?
"	CD
¦p	-p ,5
c3	C3 ^
bj)	fcuO rt
CD	CD
£ £

lO
CO
o
o
o



-M
-M
-M
CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
^ 
*
CD
G
G
0

u
0
Oh
CD
X
CD
H

i	OS X!
G i	(D '
O O C
O i—I (D '
_ R	-d :
§ ^ §
nco o
$ 'Z
MftJ
d &
¦ ~ CD T$
" ^G d
G d
CD u
G a3
"£ P G u d
O °i "i G (D
j ^
; cq r
G O \r
O V ^
° g S
x
(D CD
a3 &, "3
G 03 G
^oo
H cx-G
Oh
CD
£
CO
ft s
d
O
o
ft
X
H
CO
.3
S
s
o
Q
c
S
TJ
C
o
ft
X
H
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
0
Q
o
ft
b£)
.9
'o
05
ft
CO
CB
ft
S
O
fH
o
o
ft
X
H -
CD
0
J
£ J
^ 0 T3
O ^ §
lit
G CD _g
ia:
(D 5 o
£ 0 ^
H ao
"S
g £;
o ^
Oh G
X ' •
H
CN

1—1
CN
1—1
i—i
X
X
X
X
X
X
b£)
bi3
s
.9
^3
CD
.a
bi3
bi3
bi3
s
s
§
s
s
s
a3
fH
a3

a3
fH
¦s

X
H

J
o
CO
CQ
bi3
S
H ^
o

H
2: a
H



o
i—l
CN

00
ci
1—1
i—l
i—l
o
o
o
o
O
O

*Sh

*Sh
*Sh
*Sh
CD
CD
CD
CD
CD
CD






23

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
d
U
S *
O
CO 0)
Ci ft
CO O
J g
Oh
d o
4^ v^
^ rr

T5
• 0
c$ Qh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
0
O"
c
c3 ^
5 §
<1 ^
•	CO
o> Oi
2 3oo
^ 00
•	CD o
fe 2 oi
> !
-C f
3 -
bO
ffi ffi
<
0
o
s
o
O
^ t
(D  ••
K> Ci
b£) •
.3
^ L
r
cS
s
o
O
.3
S
3
o
Q
B
o3
"S

a3
o
bO
Oh
0
X
(D
0
't
T3

(D
<2

T3

Oj
C
0

c

(D
a
(D
0

o
3

0
'cS
^3
(D

T3
n3
(D


0
0


0
C
Oh
0
(D


•£
0


"S
.3
o
a
x
H
s
2
O
o
CN
1^
fl <$
(D
6
(D
£5 ^
> as
A 3^
H S
Oh ^
(D X
£ § 8
m 3 as
bD O >
• S bO+5
^ , S
C O 'o
<& £ Oh
¦J § c
^ O	(D
^3	(D
(D C
' o3	"'
&> .

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
d
U
S *
O
CO 0)
Ci ft
CO O
J g
Oh
d o
4^ v^
^ rr

T5
• 3
c$ Qh
O S
"§ £
J M
CD
bO +e
O o
'O o
c3
3
O"
c
c3 ^
5 §
<1 ^
•	CO
o> Oi
2 3oo
^ 00
•	CD o
fe 2 oi

>>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^

CIh	^
<1>	C6
o	co
O	CO

fa "	0
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
0
J
co"
01
V ¦
bj)
S3
>
o
Eh
h &
c3
S3
.2
;+=
-3
T3
c3
S3
CT
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
TJ

-a
.Sf
. 'JB
S-i
£
.2h
*£

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
3
>
s °
Ci
CO P
^ Si
J ,3
CC
0	Ph
2:
^ &
g .3
fH fH
P GO
8 M
U CO
^ s
S M
1	Oh
O S
"§ £
J n
CD
>> pP
8 .a
*
£
c3
P
O"
C
• CO
s o>
O O
c3
P
O"
C
'ms
p
o
• CD	o
fc 2	oi

2 c
-£ o
H £
,-P ,-P
bX) bi3
2 £
p
o
CO
p	p
c3	c3
-4-3	-M
CO	CO
^	&
P	P
CO	CO
-m	-m
CO	CO
$	$
d) 1—I	CS|
p -g	-g
c6
i® -m	-m
-g s	s
CO
H
.s
s
s
o
Q
H
(X £
u	o	^	"£
CD	CD	CD	S
^	^	^	CX
H	H	H	£
fcuO fcuO g
2 2 j
Ph ^
O
O O =\
fH fH '"I
O O TJ
O O g
g s a
^	o
C3 C3	32
bX) fcuO P
CD 
-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
3
>
s	°
Ci
CO	P
^	Si
J	,3
CC
0	Ph
2:
^	&
g	.3
fH	fH
P	GO
8	M
U	CO
^	s
S	M
1	Oh
O	S
"§	£
J	n
CD
>>	pP
8	.a
*
£
CJ
c3
P
O"
<
&	^
P	§
5	§
<1	pP
•	CO
f5	o>
2	3oo
^	00
•	CD o
fe	2 oi

m

p
.2
p
o
o
H
44-H
O
r>~>
CJ
C3
p
a"
a)
"0
C

lO
CO
i—i
1—1
1—1
.2
.2
.2




-M

CD
CD
CD



(D (D
S a)
S 3
(D (D
£ .s
pp
bO
bj)
o
TJ
o
pp
C
P
O
.s
s
s
o
Q
C
cd
s
o
a
4^
P
o
! >> !
-C f
3 '
pP
bO
ffi ffi
<
P
o
p
o
O
^ t
(D 
__ fcuO
O .3
£ TJ
o
O
a)
g -§
0	a)
1	1 o
s °
¦ ¦ O 5h
| U Ph
¦> ••
K> Ci
b£) •
.3
^ L
P r
P
<8
P
o
O
.3
S
3
o
Q
£P ^
o ><
o c
ex o
.3
O
ft
X
H
p
P
O
o
CN
1^
fl <$
(D
6
(D
£5 ^
> as
A 3^
H S
Oh ^
(D X
£ § 8
m 3 as
bO O >
• S bO+5
S
C O 'o
^ ^ Oh
¦J § c
^ O (D
X (D
(D C
' o3 "'
d> .

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
3
>
s °
Ci
CO P
^ Si
J £
. ^
O Ph
P GO
8 m
U CO
^ s
S M
| Oh
O S
"§ £
J n
CD
&
bi3 +e
O o
'o o
c3
P
<
& ^
P §
<1 ,-P
•	CO
f5 o>
2 3oo
^ 00
•	<1) O
fe 2 oi
>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^

a	U
<1>	<$
o	co
O	CO

>
fa "	O
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
o
J
co"

o
Eh
c3
S3
.2
;+=
-3
TJ
c3
S3
cr
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
T3

-a
.Sf
. 2
bO
v .3 J>
M-H
O ^
s ^
OJ .tt
c s
2 0)
JS
Al
5 o ^
.2 43 d)
"B I s
S'gi
&•£?
b. K
** o '
V d a;
o « -g
Al"g <6
c3
"	IW
+=>	_d
bO 3	+3
ffi °	m
t3	a
0) 0)	*5_|
t-l CO	+3
d) 03	(1)
-a o	^
s s	s
28

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
O
O
o
T5
.a
2
Oh
S
2
bi3
o
a
H
s
bi3
O
o
£
9	co
a>	a)
.3	?
8	£
cl	a)
X	"E
H	g
s
a>
s
a
s
s
o
o
c3
a3
a) . -
Q 'aT
s
° s
o A
<1	o	a
r	V	00
CO	P	Ci
<	^	O
mug
s
.2
..
a3 -
U	^
"	Q
(D Oh
S £

I Oh
^ £
Hffl h
H H
CN i—1
CN t-l
CN i—1
CN t-l
XXX
X X
^ ^

bJO bJO bO
bJO bO
S £ £
s s
CO

a)
a
S
a3
CO
H
.s
s
s
o
Q
0
o
CO
.Q
3
CO
H H H
TS
T> £
"tf f5
a* fi
(D O
X! "H
n3 0
T3 3
C ^
nj O
T3 Oh
0 0
° v.
Oh 5
(D ^
n
O TS
U (D
¦-1 j -R
S S
o o
O O
^ lO
o
rH ^H ^H
bD 
ft
c6 ^
.S H
fH
a)
fl
s
TJ
C
o
Oh
X
H
fl
o
O
s
o
O
s
cd
CD
CO
H
s
a)
a"
"0
S
a3
S
O
0
Q
o
Oh
X
H
b£)
.9
'a
a5
Oh
CO
CB
Oh
2
O
fH
o
o
Oh
X
H -
a>
&
J
£ J
^ 0 -c
o ^ §
lit
9 0 5
is:
(D 5 o
£ 0 ^
H Oh O
"S
c ^
o ^
Oh 3
X ' •
H
pS3

.a


.a
b£)
bJO
bJO
bJO
bJO
bO
s
s
s
s
s
s
a3

a3

X

fH
a3

fH
-H

H

Oh
S
S

44-H

J
o
CO
CQ
bJO
s
H



o

CN

00
ci



o
o
o
O
O
O

*Eh

*Sh
*Eh

-M

4^



a)

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
O
O
o
T5
PQ
2
Oh
S
2
bi3
o
a
H
s
bi3
O
o
£
S	co
a>	a)
.3	?
8	£
cl	a)
X	"E
H	g
44-1	a
O	hh
"S
a)
a	%
h	&
a)	. -
Q	'aT
°	S
o	A
^	O OJ
r	V 00
CO	P Ci
<1	^ O
ffloS
s
.2
..
as a)
.t5 &
° Eh 0
^ o
J +"? fH
£ <$ 
I
$ ..
£ o
s
.2
s
o
O
H
44-H
O
CJ
a5
s
a"

S 3
(D (D
^ .s
b£)
bJO
o
TJ
o
C
O
.5
3
S
o
Q
C
a)
s
o
a
4^
3
o
! >> !
X f
3 -
b£)
ffi ffi
c
2
o
s
o
O
^ t
(D (D
"£ C
bJO
2
s
a3
S
.5?
*53
a)
Q
H
g
'Sh
__ bJO
O .3
o
O
a)
g -§
0	a)
1	1 o
s °
¦ ¦ O 5h
I U Ph
¦> ••
K> Oi
bJO •
.3
^ L
r
cS
s
o
O
.3
S
3
o
Q
£P ^
o ><
o c
ex o
.3
O
ft
X
H
s
O
o
CN
Oh ^
(D ^3
g §
>
3 cd 0
^ Oh
H V
bD O >
• S bO+5
^ , S
C O 'o
ta ^ a
¦o § s
^ O (D
X (D
(D C
t-H aj +=
1) p I)
S S|
5	B B
6	+? (D
lx! ® +=
a; a; a;
^ T!
«2 ^ S
M-H 0 H-
M 03 ^
ro J) +j
"£ fH 5
Q ^2 &
b£)
T5
O
^ o
ri
m rn
T?
s
a3
S
O
c3
4^
CO
c$
"§
Q
.3
S
3
o
Q
b£)
ffi ffi
a5
Q
bJO
o
Oh
a)
bJO
2
Ph
X
a>
S
S
.2
*+^
a5
S
ag
^Oh
X
H
i—i
CN
CO
CN
CN
CN
.2
.2
.2
'Eh
'Eh
'Eh


-M
a)
a)
a)



30

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
O
O
o
T5
&
2
Oh
S
2
bi3
o
a
H
s
bi3
O
o
£
S	co
a>	a)
.3	?
8	£
cl	a)
X	"E
H	g
s
a>
s
"5 cr
&«<
Oh


S3
O

1
Oh
CO

0
>s

S3
03

CO


c3
-a
"aS

<
+3
O
S3

ST
>s


c3

4f
s
<:


cu

3
H

c3


+3

Oh


a)
CC

o
Oj

o
Oj

c3
a)

S3
£
o
a)
S3
S-l
. -
CO
0
co
c3
+3
o
||
T3
<5


fa
&
+3
c6
bj)
.s
0
J
3
3a
of
o
a)
Ch ^
s ffi
-Q
c3
c3
S3
£
>>
S3
c3
T3
S3
S3
0
W
w
co
VI
o
4^
co
c4
Al
£
o
J
co"

o
: ^ i*
J a) c3
c3
n ' ' f-1
II <1>
>
fa " 0
& 3^
H
c3
S3
.2
;+=
-3
T3
c3
S3
CT
>>
c3
s
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
TJ

-a
.Sf
. 2
bO
v.S £
M-H
O ^
s ^
OJ .tt
c s
£ 0)
JS
Al
S O ^
.2 43 d)
"B I s
S'gi
&.£?
b. K
** o '
V d a;
o « -g
^ ^
—i fl3 Al
c3
All
^	^
+3	_d
bO 3	£
ffi °	m
t3	a
0) 0)	*5_|
S-l CO	+3
d) 03	(1)
-a o	^
s s	s
31

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
O
O
TJ
CD
3
Oh
S
2
bj)
O
a
H
s
§ -f
s I
ft _5f
a) 
^ t-—
Jh ®
»
2	X
o	2
CO	Ph
fl S
C3 G$
2	3
CO	CO
-M	+J
cc	cc
£	£
1—1
CN
CO
o
O
o






CD
CD
CD



(X £
u u (_,	"£
CD CD CD	S
^ ^ ^	CX
H H H	£
P^H -=H i.
M M g
K S J
fl
o
O O
X	g
o	^
M	j
3	^
O	T?
"	CD
¦p -p ,5
a3 a3 32
bj) fcuO rt
CD CD c3
£ £

lO
CO
O
o
o




-M

CD
CD
CD



H
.s
s
s
o
Q
2 'S
n
^ (D
a
£ a-
^ .s
§ ^
d o
-o £
§ £
rH ^
s ^
£ CD
S® CD
5? £
^ .2
"S ^
C CD
CD d •
as t
'£ M °
CD CD ft
Oh^ £
X
CD
O CD
Jl
H :
0.'

3

0

Oh

X

CD

T3

d

a3
Oh


T3
0
-0;


bO
0

O.T3
CD
3



CD
*
^3
C
VI
0
0
"S
CJ
S
a3
0
C

S
"b
CD
C
3
0

u
0
Oh
CD
X
CD
H
£
i as	X!
fl i	CD '
O O	C
cj t—i	CD '
_ R	-d :
§	§
h co	o
$ £;
bO Oh O
d Oh
• £ CD tS
" ^ fi
"E ? C u d
o "3 "3 fl CD
j ^
; cq r
>»
. -o
, ^
CD CD
d o \r
O V *2
u g 8
f1 u n3 •
£ 0 0
Oh
CD

CO
ft s
g3
V
0
Oh
X
H
01
.3
S
S
o
Q
fl
S
TJ
C
o
Oh
X
H
s
o
O
s
cd
-m
CB
CO
H
s
CD
O"
T5
S
o3
S
O
0
Q
o
Oh
b£)
.9
'o
05
Oh
CO
CB
Oh
S
O
fH
o
o
Oh
X
H -
CD
0
J
£ J
^ 53 T3
O ^ §
lit
9 ® Z
hi
(D 5 o
£ 0 ^
H ao
"S
c ^
O £2
Oh d
X ' •
H
CN
i—i
1—1
CN
1—1
i—i
X
X
X
X
X
X
bi3
bi3
s
.9
^3
CD
bi3
bi3
bi3
s
s
§
s
s
£
o3
fH
03

o3
fH
¦s

X
H

J
£i
£
O
CO
CQ
bi3
S
H
o

H
2: a
H



o
i—l
CN

00
6i
1—1
i—l
i—l
o
o
o
o
O
O

*n

*n
*Sh
*Sh
CD
CD
CD
CD
CD
CD






32

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
O
O
TJ
CD
3
Oh
S
2
bj)
O
a
H
i
a £
S I
ft _5f
CD 
^3
s
o
O
s
c3
S
o
<
l_q .c
RE
£P o £
° 0) 0
I (D
.3 ^
pj b0
0	'3
T3 .S
C a3
1	E
c 5
•2 v
1 =
§ S"
" -a
In 05
T3
Cm
£ 05 B
3 ^ .2
•- <" 5
"2 = §
B s S?
^ IB O
(D CD
^ (D <»
| O u jj> 'o
H
I—, C
Q o £
H '¦£ $
O S,S
bj)
2
CD
ft
bj)
2
s
a3
S
a3
bO
fH
o
CD
I
^ ..
£ o
s
.2
+^>
^3
s
o
O
H
44-H
O
CJ
&
2
a"
CD
c

lO
CO
1—1
i—l
1—1
.2
.2
.2

*Eh

-M


CD
CD
CD



(D (D
S a>
S 3
(D (D
£ .£
bO
bj)
o
TJ
o
C
3
O
.s
3
3
o
Q
C
CD
s
O
a
4^
3
o
! >> !
-c f
3 -
bO
ffi ffi
c
2
o
s
o
O
^ <
(D  ••
K> Ci
b£) •
.3
^ L
r
cS
s
o
O
.3
S
3
o
Q
£P ^
o *
o c
ex o
.3
O
ft
X
H
s
O
o
CN
X
(D	"3
^	Oh
M	3
bO	o :
• B	bi c
S	P a
! t3
2	c S
M	(D ^
O	fl 0
n.	^ -u
^ O
H '55
b£)
T5
O
^ o
ri
m rn
s
a3
S
O
c3
4^
CO
c$
"§
Q
.3
S
3
o
Q
b£)
ffi ffi
a5
Q
bi3
o
Oh
CD
H
bi3
2
0
o
T5
,;D
Oh
X
CD
s
S
.2
a3
fl
ag
Oh
X
H
CO
CN
33

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
CO
O
O
TJ
CD
3
Oh
S
2
bj)
O
a
H
^ I
ft _5f
a)  o
"§ Ci
i-3 t"—
2 o
^ U (—5
PQ C S
s
.2
..
c3 a)
Oh
° Eh 0
^3 c$ o
^ +¦? f-f
r, <£ a)
co Q ffi
bj)
S3
-Q
c3
c3
S3
£
>>
S3
c3
O	>>
S3	<8
co	P
5s	r3
-c	03
=11
£	>»
c3
^	S
"	^
a)	Oh
3	H
"£?	r*>
CIh	^
a)	c6
o	co
O	CO
 ^
^ -	cfi
ii 1—1
,,	<1>
>
fa "	O
|3.S
S ffi
T3
S3
S3
O
w
w
co
VI
o
4^
co
c4
Al
£
0
J
co"
01
V
bO
S3
>
o
h &
c3
S3
.2
;+=
-3
T3
c3
S3
CT
T3
S3
c3
>;
T3
S3
a
>>
o
a)
a
x
a)
CO
c3
a)
o
S3
a)
T3

-a
.£P
. 2
S-i
£
.2h
*£
0)
bO
S3 5-1
! a)
: -C
Eh
Al
s
.2 ^ o
^ is
S-gi
&•£?
b. K
** o '
V d a;
° S ts
Al"g	«
	_d
bO S3	£
ffi °	m
t3	a
0) 0)	*5_|
S-l CO	+3
d) 03	(1)
-a o	^
s s	s
34

-------