PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
>=,EPA
United States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Risk Evaluation for
N-Methylpyrrolidone
Systematic Review Supplemental File:
Data Quality Evaluation of
Consumer and General Population Exposure Data Sources
CASRN: 872-50-4
October 2019
1

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Monitoring
Study Citation:	Kiefer, M.. 1994.0. Health Hazard Evaluation Report No. HETA-93-0844-2411, Rosebud Company, Atlanta, Georgia.
Data Type	Monitoring
Hero ID	3836708
Domain	Metric	Rating^ Score	Comments
Domain 1: Reliability
Metric 1: Sampling Methodology	Medium
Metric 2: Analytical Methodology	Low
Metric 3: Biomarker Selection	N/A
2	provided amount of product applied, square footage of floor
covered, percent ai in product, application description, nom-
inal air flow rate, sampling duration, activity monitored. No
discussion of storage conditions and duration.
3	OSHA Stop-gap method M139, no description of method pro-
vided. No discussion of laboratory controls, calibrations, op-
erating conditions.
N/A No Comment.
Domain 2: Representativeness
Metric 4:
Metric 5:
Metric 6:
Metric 7:
Geographic Area	High	1
Currency	Low	3
Spatial and Temporal Variability	Low	3
Exposure Scenario	Low	3
No Comment.
1993.0
Only 2 trials.
Use of paint stripper on floor, not sure if a consumer would
use an electric buffer and sawdust?
Domain 3: Accessibility/Clarity
Metric 8: Reporting of Results
Metric 9: Quality Assurance
Medium
Low
2
3
no raw data reports.
No discussion of breakthrough results for sampling train. Field
blanks used. No results of recoveries, blanks, correction if
needed, etc.
Domain 4: Variability and Uncertainty
Metric 10: Variability and Uncertainty
Low
3
little discussion of uncertainty.
Overall Quality Determination
Low
2.6

Extracted
Yes



r High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
2 Experimental
Study Citation: M. Nohr, W. Horn, O. Jann, M. Richter, W. Lorenz. 2015.0. Development of a multi-VOC reference material for quality
assurance in materials emission testing. Analytical and Bioanalytical Chemistry.
Data Type	Experimental
Hero ID	2718034
Domain	Metric	Ratingt Score	Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Metric 3:
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
Medium
Low
N/A
2
3
N/A
Development of new method, micro chamber.
No LOQ provided in article. Method described elsewhere.
No Comment.
Domain 2: Representative
Metric 4:
Metric 5:
Metric 6:
Testing Scenario
Sample Size and Variability
Temporality
Medium
Low
High
2
3
1
The emissions is from volatility in a petri dish. The product
was not "applied".
Three batches of same product.
No Comment.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
No raw data,
not discussed.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
High
1
RSD provided, discussed influence on humidity, chamber flow.
Overall Quality Determination
Medium
2.0

Extracted

Yes


1 High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Wolkoff, P.. 1998.0. Impact of air velocity, temperature, humidity, and air on long-term VOC emissions from building products.
Atmospheric Environment.
Data Type	Experimental
Hero ID	3005854
Domain	Metric	Rating^"	Score	Comments
Domain 1: Reliability
Metric 1
Metric 2
Metric 3
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
High
High
N/A
1
1
N/A
No Comment.
No Comment.
No Comment.
Domain 2: Representative
Metric 4
Metric 5
Metric 6
Testing Scenario
Sample Size and Variability
Temporality
Medium
Unacceptable
Low
2
4
3
indoor air study, but consumer products are not clarified,
sample size is not reported.
> 15 years old
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Unacceptable
N/A
4
N/A
no results for NMP.
discussed spiked samples, but only limited QC is discussed.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
discussed influence of temperature and other parameters.
Overall Quality Determination
Unacceptable
4.0
Metric mean score**: 2.4.
Extracted

No


** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score =
4), EPA will determine the study to be unacceptable. In this case, two of the metrics were rated as unacceptable. As such, the study is considered unacceptable
and the score is presented solely to increase transparency,
t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Bader, M.,Keener, S. A.,Wrbitzky, R.. 2005.0. Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone. Inter-
national Archives of Occupational and Environmental Health.
Data Type	Experimental
Hero ID	3539719
Domain	Metric	Ratingt Score	Comments
Domain 1: Reliability




Metric 1:
Sampling Methodology and Conditions
Medium
2
no standard methodology mentioned, but detailed methodol-




ogy provided.
Metric 2:
Analytical Methodology
High
1
NMP in urine was analysed according to A " kesson and Pauls-




son (1997a, b).. LOQ provided.
Metric 3:
Biomarker Selection
N/A
N/A
The analyzed NMP in urine, but not for the purpose of expo-




sure to a consumer product, but to look at dermal absorption,
Domain 2: Representative




Metric 4:
Testing Scenario
Medium
2
The pure chemical was tested, not a product.
Metric 5:
Sample Size and Variability
Medium
2
7 volunteers.
Metric 6:
Temporality
High
1
2005 study, but since experimental time is not critical.
Domain 3: Accessibility/Clarity



Metric 7:
Reporting of Results
Medium
2
no raw data
Metric 8:
Quality Assurance
N/A
N/A
QC not discussed.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty	Low	3 No Comment.
Overall Quality Determination	Medium 1.9
Extracted	No
f High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Keener, S. A.,Wrbitzky, R.,Bader, M.. 2007.0. Human volunteer study on the influence of exposure duration and dilution of
dermally applied N-methyl-2-pyrrolidone (NMP) on the urinary elimination of NMP metabolites. International Archives of
Occupational and Environmental Health.
Data Type	Experimental
Hero ID	3539848
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability
Metric 1:
Sampling Methodology and Conditions
High
1
Application of product to hand described in described by Bader
et al. (2005a).. The samples were stored at 28"C before anal-
ysis.
Analysed as described by J" nsson and " kesson (1997). GC/MS.
Calibration standards were prepared from a blank urine pool.
The parameters 5-HNMP, 2-HMSI and creatinine in urine were
certified within round-robins of the German External Quality
Assurance Scheme
No Comment.
Metric 2:
Metric 3:
Analytical Methodology
Biomarker Selection
High
High
1
1
Domain 2: Representative
Metric 4:
Metric 5:
Metric 6:
Testing Scenario
Sample Size and Variability
Temporality
Medium
Low
High
2
3
1
Consumer product not applied. Multiple testing scenarios were
conducted however (different concentrations).
Only 4 volunteers.
2007, but temporality not as relevant due to study design.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
no raw data
use of blanks, corrections for recovery rate of NMP in urine
(65 percent)
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
No Comment.
Overall Quality Determination
High
1.6

Extracted

No



1 High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
6

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Study Citation: Ursin, C.,Hansen, C. M.,Van Dyk, J. W.,Jensen, P. 0.,Christensen, I. J.,Ebbehoej, J.. 1995.0. Permeability of commercial
solvents through living human skin. American Industrial Hygiene Association Journal.
Data Type	Experimental
Hero ID	3540771
Domain	Metric	Ratingt Score	Comments
Domain 1: Reliability
Metric 1
Metric 2
Metric 3
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
High
Low
N/A
1
3
N/A
No standard method mentioned, but sapling well described.
GC method; no details provided.
No Comment.
Domain 2: Representative
Metric 4
Metric 5
Metric 6
Testing Scenario
Sample Size and Variability
Temporality
Medium
Low
High
2
3
1
permeability of the solvent, not a consumer product,
appears to be <5 samples
1995 study, but temporality is not key to a lab study.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
No raw data
limited discussion
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
No Comment.
Overall Quality Determination
Medium
2.0

Extracted

No


t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: U.S, E. P. A.. 1994.0. Consumer exposure to paint stripper solvents.
Data Type	Experimental
Hero ID	3808963
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Metric 3:
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
High
Medium
N/A
1
2
N/A
Test protocol was provided. Each of the selected products was
tested in triplicate under controlled environmental conditions
inside MAl's Air Consumer Exposure (ACE) Laboratory expo-
sure chamber for a total of 15 experiments. The paint strippers
were used according to the manufacturers' instructions printed
on the label. The application procedure was consistent with
previous laboratory studies conducted at the Lawrence Berke-
ley Laboratory (Girman and Hodgson, 1986). All pertinent
sampling information is provided: test chamber preparation,
sampling equipment, test conditions, etc.
D. Details of the analytical method were provided in Appendix
C. NMP samples were analyzed using a method developed by
GAF and partially validated by OSHA.. GAF/OSHA. Gas
Chromatography (GC) equipped with FID
Biomarker is not used.
Domain 2: Representative
Metric 4:
Metric 5:
Metric 6:
Testing Scenario
Sample Size and Variability
Temporality
High
Medium
Low
1
2
3
Testing conditions closely represent relevant exposure scenar-
ios. The objective of this study is to determine consumer ex-
posure to solvents contained in commercially available paint
strippers under typical product-use scenarios.
Moderate sample size. For Wood Finisher's Pride (the product
that contained NMP) three test runs were conducted; six sam-
ples were collected during each test run: pretest background,
test chamber (center, inlet side, and outlet side), breathing
zone, and supply to test chamber.
>15 years; Report date 1994
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
Test Results for Integrated Air Sampling for Wood Finisher's
Pride (NMP product) reported in Table 9.
Blind spikes samples were prepared at MAI and submitted to
DataChem Laboratories, Inc. with the regular air sampling
media. The blind spikes were prepared by injecting a known
volume of each of the target analytes onto the appropriate sor-
bent tube with a microliter syringe.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
key uncertainties, limitations, and data gaps are not discussed.
Continued on next page
8

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— continued from previous page
Study Citation:
Data Type
Hero ID
U.S, E. P. A.. 1994.0. Consumer exposure to paint stripper solvents.
Experimental
3808963

Domain
Metric Ratingt Score
Comments

Overall Quality Determination Medium 1.9
Extracted
No


t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
9

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Study Citation:
UL Env. 2017.0. Floor Coating VOC Emissions Research Report.

Data Type
Experimental

Hero ID
4440489

Domain
Metric Rating^ Score
Comments
Domain 1: Reliability
Metric 1
Metric 2
Metric 3
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
Medium
Medium
N/A
2
2
N/A
No Comment.
No Comment.
No Comment.
Domain 2: Representative
Metric 4
Metric 5
Metric 6
Testing Scenario
Sample Size and Variability
Temporality
High
Medium
Medium
1
2
2
No Comment.
No Comment.
No Comment.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
No Comment.
No Comment.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
No Comment.
Overall Quality Determination
Medium
1.9

Extracted

Yes


t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
10

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Study Citation: Delmaar, J. E.. nan. Emission of chemical substances from solid matrices: a method for consumer exposure assessment.
Data Type	Experimental
Hero ID	4663189
Domain
Metric
Haling1
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Metric 3:
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
Low
Low
N/A
3
3
N/A
secondary review article with experimental data cited in sup-
port of modeling approach.
secondary review article with experimental data cited in sup-
port of modeling approach.
No Comment.
Domain 2: Representative
Metric 4:
Metric 5:
Metric 6:
Testing Scenario
Sample Size and Variability
Temporality
Low
Low
Low
3
3
3
approach requires equilibrium assumption for article exposure,
not all chemicals have article scenarios.
No Comment.
point in time estimate for approaches based on regressions and
measured data available to date.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Low
N/A
3
N/A
No Comment.
No Comment.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Low
3
No Comment.
Overall Quality Determination
Low
3.0

Extracted

No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: A. T. Hodgson. 2001.0. Predicted concentrations in new relocatable classrooms of volatile organic compounds emitted from
standard and alternate interior finish materials.
Data Type	Experimental
Hero ID	4683360
Domain
Metric
Ratingt
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Metric 3:
Sampling Methodology and Conditions
Analytical Methodology
Biomarker Selection
High
High
N/A
1
1
N/A
No Comment.
No Comment,
no biomarkers
Domain 2: Representative
Metric 4:
Testing Scenario
Medium
2
kind of products, test substance, testing methods are de-
scribed. But exposure control is not discussed, and temper-
ature/pressure are assumed value for estimation of concentra-
tion.
2-4 products samples per product type.
>15 yrs old
Metric 5:
Metric 6:
Sample Size and Variability
Temporality
Low
Low
3
3
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
Medium
N/A
2
N/A
Each results are summarized in each tables. The value in each
tables are not raw data though, raw values of concentration
are possibly calculated by equation(l). Statistical discussion
is missed.
QC discussion is quite limited.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Low
3
Variability/Uncertainty discussion is quite limited.
Overall Quality Determination
Medium
2.1

Extracted

Yes


1 High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation:
DTI. 2004.0. Survey of chemical substance in consumer products.

Data Type
Experimental

Hero ID
5035312

Domain
Metric Rating^ Score
Comments
Domain 1: Reliability
Metric 1; Sampling Methodology and Conditions Low	3 Small number of samples (10); not clear if replicate samples
used
Metric 2: Analytical Methodology	High	1 No Comment.
Metric 3: Biomarker Selection	High	1 No Comment.
Domain 2: Representative
Metric 4: Testing Scenario
Metric 5: Sample Size and Variability
Metric 6: Temporality
High
Medium
N/A
1
2
N/A
No Comment.
Sample size is low (10)
No Comment.
Domain 3: Accessibility/Clarity
Metric 7: Reporting of Results
Metric 8: Quality Assurance
High
N/A
1
N/A
No Comment.
No Comment.
Domain 4: Variability and Uncertainty
Metric 9: Variability and Uncertainty
Medium
2
Greater number of samples and replicate samples could reduce
uncertainty
Overall Quality Determination
High
1.6

Extracted
No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Databases Not Unique to a Chemical
Study Citation: U.S, E. P. A.. 2017.0. STORET: N-methylpyrrolidone.
Data Type Databases Not Unique to a Chemical
Hero ID 3970048
Domain
Metric
l lal iT i g
Score

Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Sampling Methodology
Analytical Methodology
High
High
1
1
No Comment.
No Comment.

Domain 2: Representative
Metric 3:
Metric 4:
Metric 5:
Geographic Area
Temporal
Exposure Scenario
High
High
High
1
1
1
No Comment.
No Comment.
No Comment.

Domain 3: Accessibility/Clarity
Metric 6: Availability of DB and Supporting Documents
Metric 7: Reporting Results
High
High
1
1
No Comment.
No Comment.

Domain 4: Variability and Uncertainty
Metric 8: Variability and Uncertainty
N/A
N/A
No Comment.

Overall Quality Determination
High
1.0


Extracted

No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Consumer Product Information, Database. 2017.0. What's in it? n-methylpyrrolidone.
Data Type	Databases Not Unique to a Chemical
Hero ID	3981162
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Sampling Methodology
Analytical Methodology
Low
N/A
3
N/A
Webpage provides only very limited info. Brands selected
based on market share.
No Comment.
Domain 2: Representative
Metric 3:
Metric 4:
Metric 5:
Geographic Area
Temporal
Exposure Scenario
High
High
High
1
1
1
USA and Canada database
"Date verified" provided, some <5 yrs old.
Weight fractions of consumer products.
Domain 3: Accessibility/Clarity
Metric 6: Availability of DB and Supporting Documents
Metric 7: Reporting Results
Low
High
3
1
No info how data collected or QC provided.
Data is organized. No summary provided, so summary stats
not applicable
Domain 4: Variability and Uncertainty
Metric 8: Variability and Uncertainty	N/A	N/A Based on industry reported weight fraction (e.g., MSDS); not
measured data
Overall Quality Determination	Medium 1.7
Extracted	No
t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Bartzis, J.. 2018.0. Prioritization of building materials
as indoor pollution sources (BUMA).
Data Type Databases Not Unique to a Chemical


Hero ID 4663145


Domain Metric
Rating^
Score Comments
Domain 1: Reliability


Metric 1: Sampling Methodology
N/A
N/A Sampling method not discussed - secondary source of info.
Metric 2: Analytical Methodology
N/A
N/A Analytical method not discussed - secondary source of info.
Domain 2: Representative
Metric 3: Geographic Area
Metric 4: Temporal
Metric 5: Exposure Scenario
High
Medium
Medium
1
2
2
No Comment.
Data of various ages.
Not an exact match except for NMP
Domain 3: Accessibility/Clarity
Metric 6: Availability of DB and Supporting Documents
Metric 7: Reporting Results
High
High
1
1
No Comment.
References listed. Emission rates were from fits to concentra-
tion data.
Domain 4: Variability and Uncertainty
Metric 8: Variability and Uncertainty
N/A
N/A
No Comment.
Overall Quality Determination
High
1.4

Extracted
Yes


t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Completed Exposure Assessments
Study Citation: Rivm,. 2013.0. Annex XV Restriction Report: Proposal for a
Data Type Completed Exposure Assessment
Hero ID 3809440
Restriction.
Domain Metric Rating^
Score
Comments
Domain 1: Reliability
Metric 1: Methodology Medium
2
lit search or data collection methods are not described.
Domain 2: Representative
Metric 2: Exposure Scenario Medium
2
scenario interest, relatively new study.(within 5 yrs) but not
the US.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty Low
3
variability/uncertainty is not discussed well.
Overall Quality Determination Medium
2.0

Extracted No

t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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Study Citation: Who,. 2001.0. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Data Type	Completed Exposure Assessment
Hero ID	3809476
Domain	Metric	Rating^ Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Medium 2 No discussion of lit search techniques
Domain 2: Representative
Metric 2: Exposure Scenario
High
1
No Comment.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References
High
1
waste water effluent
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty
Low
3
No Comment.
Overall Quality Determination
Medium
1.8

Extracted
No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
18

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation:	Danish EPA. 2015.0. List of Undesirable Substances (LOUS): Survey of l-methyl-2-pyrrolidone.
Data Type	Completed Exposure Assessment
Hero ID	3827507
Domain	Metric	Rating^ Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Medium 2 No Comment.
Domain 2: Representative
Metric 2: Exposure Scenario
High
1
No Comment.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References
High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty
Medium
2
No Comment.
Overall Quality Determination
High
1.5

Extracted
No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
19

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: Echa,. 2014.0. Background document to the opinion on the annex XV dossier proposing restrictions on l-methyl-2-pyrrolidone
(NMP).
Data Type	Completed Exposure Assessment
Hero ID	3827511
Domain	Metric	Ratingt Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	1 No Comment.
Domain 2: Representative
Metric 2: Exposure Scenario
High
1
No Comment.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References
High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty
High
1
No Comment.
Overall Quality Determination
High
1.0

Extracted
No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
20

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: Australian Government Department of, Health. 2016.0. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Data Type Completed Exposure Assessment
Hero ID 3969286
Domain Metric Rating^
Score
Comments
Domain 1: Reliability
Metric 1: Methodology High
1
No Comment.
Domain 2: Representative
Metric 2: Exposure Scenario Medium
2
in Australia.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty Medium
2
multiple weight fractions are discussed though, variability/
uncertainty is not described clearly.
Overall Quality Determination High
1.5

Extracted Yes

t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
21

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: Environment, Canada. 2017.0. Draft screening assessment: 2-Pyrrolidinone, 1-methylO (NMP) and 2-Pyrrolidinone, 1-ethyl
(NEP).
Data Type	Completed Exposure Assessment
Hero ID	3969287
Domain	Metric	Ratingt Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	1 No Comment.
Domain 2: Representative
Metric 2: Exposure Scenario
High
1
No Comment.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References
High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty
Low
3
No Comment.
Overall Quality Determination
High
1.5

Extracted
No



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
22

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: H. Willem, B. Singer. 2010.0. Chemical emissions of residential materials and products: Review of available information.
Data Type Completed Exposure Assessment
Hero ID 4683373
Domain Metric Rating^
Score
Comments
Domain 1: Reliability
Metric 1: Methodology High
1
No Comment.
Domain 2: Representative
Metric 2: Exposure Scenario Low
3
US report, but a bit old report(> 5yrs) and no chemicals in-
terest.
Domain 3: Accessibility/Clarity
Metric 3: Documentation of References High
1
No Comment.
Domain 4: Variability and Uncertainty
Metric 4: Variability and Uncertainty High
1
No Comment.
Overall Quality Determination High
1.5

Extracted No

t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Survey
Study Citation: U.S, E. P. A.. 1987.0. Household solvent products: A national usage survey.
Data Type	Survey
Hero ID	1005969
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability




Metric 1:
Data Collection Methodology
High
1
No Comment.
Metric 2:
Data Analysis Methodology
High
1
No Comment.
Domain 2: Representative




Metric 3:
Geographic Area
High
1
Nationwide (U.S.A.) survey with outreach via random dialing




and willingness to provide address and respond to survey.
Metric 4:
Sampling / Sampling Size
High
1
No Comment.
Metric 5:
Response Rate
Medium
2
No Comment.
Domain 3: Accessibility/Clarity



Metric 6:
Reporting of Results
High
1
No Comment.
Metric 7:
Quality Assurance
Medium
2
No Comment.
Domain 4: Variability and Uncertainty



Metric 8:
Variability and Uncertainty
N/A
N/A
No Comment.
Overall Quality Determination	High	1.3
Extracted	Yes
t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Study Citation: Abt. 1992.0. Methylene chloride consumer use study survey findings.
Data Type	Survey
Hero ID	1065590
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Data Collection Methodology
Data Analysis Methodology
Medium
Medium
2
2
Data collection instrument was described. The protocols for
field personnel was not.
Weighted summary stats provided, and unweighted counts pro-
vided in appendix. Could not find a discussion on sampling and
non sampling errors.
Domain 2: Representative
Metric 3:
Metric 4:
Metric 5:
Geographic Area
Sampling / Sampling Size
Response Rate
High
High
Medium
1
1
2
No Comment.
No Comment.
for the questionaire, response rate was about 40 percent.
Domain 3: Accessibility/Clarity
Metric 6: Reporting of Results
Metric 7: Quality Assurance
High
Low
1
3
No Comment.
No discussion of QC
Domain 4: Variability and Uncertainty
Metric 8: Variability and Uncertainty
N/A
N/A
limited discussion
Overall Quality Determination	Medium 1.7
Extracted	Yes
t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
25

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
6 Modeling
Study Citation: UL Env. 2017.0. Floor Coating VOC Emissions Research Report.
Data Type	Modeling
Hero ID	4440489
Domain
Metric
Rating^
Score
Comments
Domain 1: Reliability
Metric 1:
Metric 2:
Mathematicl Equations
Model Evaluation
Medium
Medium
2
2
Emission rates of TVOC were used in a computer model tode-
termine potential air concentrations of the pollutants. The
computer model used the measured emission rate changes over
the one-week time period to determine the change in air con-
centrations that would accordingly occur. The emission factor
can be modeled according to a first-order decay.
The emission rates calculated from these samples were used in
a mathematical model to predict the concentration that would
occur in an office environment. The model parameters were
11.1 m2 of flooring in a 30.6 m3 room with an outdoor air
change rate of 0.68/hr.
Domain 2: Representative
Metric 3:
Exposure Scenario
High
1
<5 years (2017 pub date) Table 5 reports predicted concentra-
tions of NMP from time of application to one week for floor
coatings W7 and W3 (floor loading in office)
Domain 3: Accessibility/Clarity
Metric 4: Model and Model Documentation Availability
Metric 5: Model Inputs and Defaults
High
Medium
1
2
There is sufficient documentation in the data source
Data quality acceptance criteria are not discussed but inputs
appear appropriate. The emission factor can be modeled ac-
cording to a first-order decay: EFm = EF0 e-kt where, EFm
= modeled emission factor ("g/m"hr) or ("g/unit"hr) EF0 =
initial emission factor ("g/m"hr) or ("g/unit"hr) k = rate con-
stant (hr-1) t = time (hr)
Domain 4: Variability and Uncertainty
Metric 6: Variability and Uncertainty
Low
3
No Comment.
Overall Quality Determination
Medium
1.8

Extracted

Yes



t High = 3; Medium = 2; Low = 1; Unacceptable = 4; N/A has no value.
If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High=> 1 to < 1.7; Medium => 1.7 to < 2.4; Low => 2.4 to < 3.
26

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