February 2017 Office of Chemical Safety and Pollution Prevention U.S. EPA Preliminary Information on Manufacturing, Processing, Distribution, Use, and Disposal: Anthrar2fl,9-def:6f5f10-d'e'f'1 diisoquinoline-lf3,8f10(2Hf9H)- tetrone Pigment Violet 29 CASRN: 81-33-4 February 2017 Support document for Docket EPA-HQ-OPPT-2016-0725 Page 1 of 17 ------- This document provides a preliminary public summary of available information collected by EPA's Office of Pollution Prevention and Toxics (OPPT) in the Office of Chemical Safety and Pollution Prevention (OCSPP) on the manufacturing (including importing), processing, distribution in commerce, use, and disposal of this chemical. This is based on existing data available to EPA, including information collected under the Chemical Data Reporting rule, information from other Agency databases, other U.S. Government agencies, publicly available information from states, and a review of published literature. In addition, the document includes information reported to EPA by producers and users of the chemical in the United States and in other countries. This preliminary use information and any additional use information received in the docket by March 15, 2017 will inform efforts to develop the scope of the chemical risk evaluation required under section 6(b)(4) of the Toxic Substances Control Act, and will inform any risk management efforts following risk evaluation. Mention of trade names in this document does not constitute endorsement by EPA. To verify products or articles containing this chemical currently in commerce, EPA has identified several examples. Any lists are provided for informational purposes only. EPA and its employees do not endorse any of the products or companies. This document does not contain confidential business information (CBI). Page 2 of 17 ------- TABLE OF CONTENTS TABLE OF CONTENTS 3 POINT OF CONTACT 3 MANUFACTURING, PROCESSING, DISTRIBUTION, USE AND DISPOSAL 4 1. Manufacturing (Including Importing) 4 Manufacturing Process 4 2. Processing 5 3. Products and Articles 5 4. Distribution (Includes Retailers) 8 5. Use 10 Use at Industrial Sites 12 Commercial Uses 12 Consumer Uses 12 Past and Potential Uses 12 USEFUL TYPES OF INFORMATION 13 APPENDIX: SOURCES CONSULTED 14 POINT OF CONTACT Hannah Braun, OPPT, Chemical Control Division (CCD); braun.hannah@epa.gov. (202) 564-5614 Docket: EPA-HQ-OPPT-2016-0725 Page 3 of 17 ------- MANUFACTURING, PROCESSING, DISTRIBUTION, USE AND DISPOSAL 1. Manufacturing (Including Importing) For the 2012 Chemical Data Reporting (CDR) period, data reported indicate that four sites in the United States domestically manufactured 520,916 lbs. of PV291. In the 2012 CDR reporting period there was no reported importing of PV29 to the United States. However, there may be smaller volumes imported into the U.S. not captured by the CDR, based on distributers described in Table 3. Reports for the 2012 CDR period indicate that an estimated 100-249 commercial and industrial sites with 100-499 workers use PV29. CDR data submitted in 2016 indicates that PV29 is manufactured (including imported) in the United States2. The number of firms and amount manufactured is confidential business information (CBI). The amount imported was 0 lbs; however, smaller importing operations did not report to CDR in 2016. As was the case during the 2012 CDR period, reports for the 2016 CDR period indicate that an estimated 100-249 commercial and industrial sites with 100-499 workers use PV29. PV29 is not reported to the Toxics Release Inventory (TRI). Manufacturing Process Ullmann's Encyclopedia of Industrial Chemistry describes the chemical reaction to produce PV29. "When naphthalimide is heated to 220°C with caustic potash [1310-58-3] and sodium acetate [127-09-3], the potassium salt of the leuco form of perylenetetracarboxylic diimide is formed. This product is subsequently oxidized in aqueous solution to form perylene diimide [81-33-4]... The diimide in turn forms perylene dianhydride on hydrolysis with concentrated sulfuric acid at 215°C. The diimide and the dianhydride are starting materials for the synthesis of aliphatic- and aromatic-substituted diimides. The latter constitute an important class of red dyes and pigments used in the production of color-fast plastics and coatings." (Ullmann's Encyclopedia of Industrial Chemistry, Vol. 7, Page 121, (2000)) 1 Manufacturers (including importers) are required to report under CDR if they meet certain production volume thresholds, generally 25,000 lb or more of a chemical substance at any single site. Reporting is triggered if the annual reporting threshold is met during any of the calendar years since the last principal reporting year. In general, the reporting threshold remains 25,000 lb per site. However, a reduced reporting threshold (2,500 lb) now applies to chemical substances subject to certain TSCA actions, https://www.epa.gov/chemical-data-reporting/how-report-under-chemical-data-reporting 2 Manufacture means to manufacture, produce, or import for commercial purposes. Manufacture includes the extraction, for commercial purposes, of a component chemical substance from a previously existing chemical substance or complex combination of chemical substances. (40 CFR 711.3) https://www.epa.gov/sites/production/files/2015-12/documents/cdr fact sheet importers final dec2015 O.pdf Page 4 of 17 ------- Data is available regarding the manufacture of PV29 and the activities or processes at the workplace at ECHA's website. It is copyrighted and therefore is not being reproduced here. https://echa.europa.eu/brief-profile/-/briefprofile/100.001.223 2. Processing For the 2012 CDR period, four firms reported processing PV29. The processing of PV29 is through incorporation into a formulation, mixture or reaction3. This substance is used for the manufacture of plastic and rubber products, paints, and coatings. PV29 can be used in a variety of plastics applications such as polyolefins, polyvinyl chloride (PVC), polyurethane (PUR), polystyrene (PS), styrene butadiene (SB), styrene acrylonitrile (SAN), and other polymers (BASF, 1998). http://www2.basf.us/additives/pdfs/Paliogen Redviolet K5011.pdf Processing information from the 2016 CDR period is CBI. 3. Products and Articles EPA has identified the following examples. This list is provided for informational purposes only. EPA and its employees do not endorse any of the products or companies. Table 1: List of Industrial and Commercial Products Trade name Use of the Product % by weight of chemical Link to references, SDS or industry information Domestic Products 3,4,9,10- Perylenetetracarboxyli c diimide industrial pigment, tunable laser dye, light- harvesting material, transistor, molecular switched, solar cell, and optoelectronic device. Planar perylene- and naphthalene-based diimide linkers can be employed to tether the Watson- Crick and the Hoogsteen strands of a DNA triplex, thus providing conjugates capable of targeting singlestranded nucleic acids with the formation of hairpin triplexes. NA https://www. alfa.com/en/ca ta log/044098/ https://www. alfa.com/en/co ntent/msds/USA/44098.pdf Various coatings Coating for professional use; transportation industry - light and commercial vehicles Industrial use-potentially including uses such as motors, generators, vehicle components, sporting goods, appliances, architectural uses, agricultural equipment's, oil and gas pipelines. Not available htto://www.axaltacs.com/como rate/en US.html http://www.color.tc/US SDS/SD S/US EN 1250007862 CRMX.p d| Page 5 of 17 ------- Trade name Use of the Product % by weight of chemical Link to references, SDS or industry information PAUOGEN® Red Violet K 5011 vat dyes, pigments for colouring plastics and high-grade industrial paints 75-80% http://www2.basf.us/additiv es/pdfs/Paliogen Red K358 0.pdf https://www.scribd.com/doc ument/234875898/BASF- Colourant-2005 1029 Perylene Violet 29 plastics and solvent industrial coatings applications NA http://www.pigments.eom/P roducts/Organic- Pigments/Violet/1029- Pervlene-Violet-29.aspx Perrindo Violet 29 229-4050 coating application for packaging, paper, architectural, arts and crafts, powder coatings, industrial, automotive, toner, inkjet, publication NA http://www.dic- global.com/ip/en/products/p igments/general/ http://www.sunchemical.co m/?s=violet&post tvpe filte r=product- pigment&order=asc International Products Polyketone pigment chip-C.I. Pigment Violet 29, Mauve metal decoration paint, high temperature colorant for plastic, polyester fiber, ink and adhesion NA https://www.alibaba.com/pr oduct-detail/Polvketone- pigment-chip-C-l- Pigment 553396785.html Luprofil Violet 50- 1105 C4 mass-dyeing of polypropylene yarns and fibers 40% http://www.col9.com/portal /streamer?fid=422243 http://worldaccount. basf.com/ wa/NAFTA~en US/Catalog/Pigm ents/doc4/BASF/PRD/30048503 /.odfPasset tvDe=msds/Ddf&lan suase=EN&validArea=US&urn=u rn:documentum:ProductBase E U:09007af880393a3e.pdf Palamid Violet 50- 1105 pin-dyeing of polyamide yarns and fibers 25% http://www.xvmara.com/por tal/streamer?fid=422244 Page 6 of 17 ------- Table 2: List of Consumer Products Product types Product names % by weight of chemical Link to SDS or other Information and References Water colors Utrecht Artists' Watercolors NA http://images.utrechtart.com/Content/pdf/MSDS/Utre chtArtistsWatercolors.pdf Water colors Utrecht Designers' Foundation Gouache Set of Eight, Item 6018 NA http://images. utrechtart.com/Content/odf/MSDS/Utre chtDesignersGouache.pdf Water Color Professional Water Color Tube, 14ml, Perylene Violet NA http://www.winsornewton.com/na/shop/water- colour/professional-water-colour http://d4of2briuvlio.cloudfront.net/assetfiles/3b66a5 5d-9f40-4008-afl9- ab034c5ef82aSAFETY%20DATA%20SHEET-12251-1- l.pdf https://www.amazon.com/Winsor-Newton- Professional-Pervlene- Violet/dp/B0038MlUJW/ref=sr 1 2?ie=UTF8&aid=14 81907520&sr=8-2&kevwords=pigment+violet+29 Water Color Synch romatic Transparent Water Color, 0.5 oz, Violet (29) NA https://www.amazon.com/Dr-Ph-Martins- Svnchromatic- Transparent/dp/B0090RFMXA/ref=sr 1 16?ie=UTF8& aid=1481907520&sr=8- 16&kevwords=pigment+violet+29 https://www.docmartins.com/collections/svnchromati c-transparent-bottles/products/svnchromatic- transparent-water-color-0-5-oz-29 Water Color Perylene Violet (PV29) Daniel Smith Extra Fine Watercolors NA http://www.danielsmith.com/ltemFiles/MSDS/MSDS US00144 284-600-201 03192014.PDF Water colors for painting MISSION WATERCOLOR 5-15% https://imagesO.gerstaecker.de/out/pdf/pboxx- pixelboxx- 2431076/Sicherheitsdatenblatt++MIJELLO+MISSION+G old+Aauarellfarbe.pdf Fine art painting- acrylic Winsor & Newton Professional Acrylic Perylene Violet NA http://d4of2briuvlio.cloudfront.net/assetfiles/95d92f 4a-b5be-4366-8320- 21be2477ce65SAFETY%20DATA%20SHEET-12532-l- l.pdf More broadly, perylene pigments such as PV29 are found in automotive coatings and are used for coloring fiber. Perylene pigments are also used in high performance applications and PV29 is one of 3 types of perylene pigments used for coloring plastics. When perylenes are used in olefins that are stabilized with HALS (Hindered Amine Light Stabilizers) UV Stabilizers, the stabilizers will become less effective when exposed to light and pigment concentration is high. Therefore, perylenes are not used frequently in the PVC of automotive interiors. (M. Herman, Encyclopedia of Polymer Science and Technology 3rd Ed., page 240 (2013)) Page 7 of 17 ------- EU information regarding articles that PV29 is found in is available at the ECHA website. It is copyrighted and therefore is not being reproduced here. (https://echa.europa.eu/brief-profile/-/briefprofile/100.001.223) 4. Distribution (Includes Retailers) Based on information reported to CDR 2016, one facility manufacturers PV29 for wholesale and retail trade. Table 3: List of Distributors Product Description and price References Suppliers Domestically Oakwood Products 3,4,9,10-Perylenetetracarboxylic acid diimide (468673) USA $75/100g $155/250g $24/25g $12/5g http://www.oakwoodchemical.com/Prod uctsList.aspx?CategorvlD=- 2&txtSearch=165577 Parchem Perylene-3,4,9,10-tetraformyldiimine USA Have to request quote http://www.parchem.com/chemical- supplier-distributor/Pervlene-3-4-9-10- tetraformvldiimine-007596.asDX Ark Pharm, Inc. Anthra[2,l,9-def:6,5,10-d'e'f]diisoquinoline- l,3,8,10(2H,9H)-tetraone USA 95+% $71/100g http://www. arkDharminc.com/Droduct/de tailMK307667.html AK Scientific, Inc. 3,4,9,10-Perylenetetracarboxylic diimide USA 99% $20 S&H $22.95/5g $56/25g $208/100g htto://aksci.com/item detail.php?cat=L41 9 https://www.molport.com/shop/molecule -link/MolPort-001-814-872 httD://aksci.com/sds/L419 SDS.odf TCI America 3,4,9,10-Perylenetetracarboxylic Diimide USA and Japan >95.0% http://www.tcichemicals.eom/eshop/en/u s/co m mod itv/P0984/ Suppliers or Manufacturers Internationally Bide Pharmatech Ltd. Anthra[2,l,9-def:6,5,10-d'e'f]diisoquinoline- l,3,8,10(2H,9H)-tetraone China 95+% $71/100g http://www.bidepharmatech.com/en/pro duct/detail/BD81634.html Gute Chemie- abcr 3,4,9,10-Perylenetetracarboxylic diimide European company with sale to the USA 95% €94.50/25g http://www.abcr.de/shop/en/3-4-9-10- Pervlenetetracarboxvlic-diimide-95- 91982.html/ Luminescence Technology Corp. PTCDI Taiwan >99% http://www.lumtec.com.tw/portal cl cnt page.php?owner num=cl 290785&butt on num=cl&folder id=32167&cnt id=25 7882&search field=&search word=81-33- 4&search field2=&search word2=&searc h field3=&search word3=&booll=&bool2 =&search tvpe=l&up page=l Page 8 of 17 ------- Product Description and price References 2Datbiochem 3,4,9,10-Perylenetetracarboxylic Diimide China; Have to request inquiry 97% minimum http://www.davbiochem.eom/Productl/s howproduct.php?id=16841&lang=en APIChem Technology 3,4,9,10-Perylenetetracarboxylic acid diimide China 5g 25g 100g http://chemmol.com/chemmol/suppliers/ apichemistrv/texts.php MP Biomedicals, LLC PERYLENE-3,4,9,10-TETRACARBOXYLIC DIIMIDE International with HQ in USA $39.60/lg 5g and lOg Have to request Inquiry http://www.mpbio.com/product.php7pid =05216511 MSDS Available Tetra hedron 3,4,9,10-Perylenetetracarboxylic diimide China Have to request inquiry http://www.thsci.com/TS02525.html AHH Chemical 3,4,9,10-Perylenetetracarboxylic diimide China 98% $435/500g http://www.ahhchemical.eom/product/M T-20875.html MSDS Available iChemical In 3,4,9,10-Perylenetetracarboxylic diimide Korean company with sale in USA 98% $71.28/25g http://www.ichemical.com/chemicals/cas -81-33-4 Biosynth Chemistry and Biology Perylene-3,4:9,10-tetracarboxydiimide Switzerland, Slovak Republic and USA Have to request quote https://www.biosvnth.com/en/products/li fe-science/dves-stains-indicators- labels/products/W-109285.html InterBioScreen Ltd. 7,18- diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,2 4]hexacosa- l(22),2(26),3,5(25),9,ll,13,15,20,23-decaene- 6,8,17,19-tetrone Russia company with sale in USA 92-95% $140 S&H $40/3umol $44/5umol $75/10umol https://www.molport.com/shop/molecule -link/MolPort-001-814-872 Vitas-M Laboratory, Ltd. 7,18- diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,2 4]hexacosa- l(22),2(26),3,5(25),9,ll,13,15,20,23-decaene- 6,8,17,19-tetrone Hong Kong with sale in USA >90% $65 S&H $26.50/lmg $28/2mg $31/3mg https://www.molport.com/shop/molecule -link/MolPort-001-814-872 Fluorchem 7,18- diazaheptacyclo[14.6.2.22,5.03,12.04,9.013,23.020,2 4]hexacosa- l(22),2(26),3,5(25),9,ll,13,15,20,23-decaene- 6,8,17,19-tetrone 3,4,9,10-PERYLENETETRACARBOXYLIC ACID DIIMIDE United Kingdom company with sale in USA 98% $95 S&H $12.80/lg $24.32/25g $74.24/100g https://www.molport.com/shop/molecule -link/MolPort-001-814-872 http://www.fluorochem.co.Uk/Products/P roduct?code=468673 MSDS Available Alibaba Polyketone pigment chip-C.I. Pigment Violet 29, Mauve China $8-18/kilogram https://www.alibaba.com/product- detail/Polvketone-pigment-chip-C-l- Pigment 553396785.html QINGDAO SANHUAN COLORCHEM CO., LTD. Fast Bordeaux B China Have to make inquiry http://www.cncolorchem.com/product/Fa st-Bordeaux-B.html Hangzhou Aibai Chemical Co., Ltd. Crystal Violet CFA China $l/kg minimum 100 kg http://xcolor.en.made-in- china.com/product/YoinlbedwScC/China- Pigment-Violet-27-Pigment-Violet-29.html Page 9 of 17 ------- Product Description and price References Hangzhou Dimachema Import and Export Co., Ltd. PERYLENE VIOLET DP (PV29) China Have to make inquiry http://www. dimachema. com/index.php?c =msg&id=761& Products sold in USA Utrecht Designers Gouache Utrecht Designers' Foundation Gouache Set of Eight, Item 6018 USA Watercolors $49.85 http://images.utrechtart.com/Content/pd f/MSDS/UtrechtDesignersGouache.pdf http://www.utrechtart.com/ Utrecht Designers Gouache Utrecht Artists' Watercolors USA Watercolors Utrecht Artists' Watercolor Portrait Colors, Set of 12 - $110.29 Utrecht Artists' Watercolor Landscape Set of 12 - $115.49 Utrecht Artists' Watercolor Basic Set of 6- $51.79 Utrecht Artists' Watercolor Professional Wood Box Set of 18 -$286.28 http://images.utrechtart.com/Content/pd f/MSDS/UtrechtArtistsWatercolors.pdf http://www.utrechtart.com/ Winsor & Newton Professional Water Color Tube, 14ml, Perylene Violet USA Amazon $16.93 (14ml) Winsor & Newton $21.41 (14ml) http://www.winsornewton.com/na/shop/ water-colour/professional-water-colour http://d4of2briuvlio.cloudfront.net/asset files/3b66a55d-9f40-4008-afl9- ab034c5ef82aSAFETY%20DATA%20SHEET- 12251-1-1.pdf https://www.amazon.com/Winsor- Newton-Professional-Pervlene- Violet/dp/B0038MlUJW/ref=sr 1 2?ie=U TF8&aid=1481907520&sr=8- 2&kevwords=pigment+violet+29 Dr. Ph. Martin's Synchromatic Transparent Water Color, 0.5 oz, Violet (29) USA Amazon $6.73 + 2.75 S&H (0.5oz) Dr. Ph. Martin's $7.90 (0.5oz) https://www.amazon.com/Dr-Ph-Martins- Svnchromatic- Transparent/dp/B0090RFMXA/ref=sr 1 1 6?ie=UTF8&aid=1481907520&sr=8- 16&kevwords=pigment+violet+29 https://www.docmartins.com/collections/ svnchromatic-transparent- bottles/products/svnchromatic- transparent-water-color-0-5-oz-29 5. Use PV29 is a high-performance pigment that is a reddish maroon shade with high tint strength. It is recommended primarily for plastics and solvent industrial coatings applications. http://www.pigments.com/Products/Organic-Pigments/Violet/1029-Perylene-Violet-29.aspx Page 10 of 17 ------- PV29 is found in multiple industrial, commercial and consumer products with an array of potential uses such as: Paint and Coatings • Tunable laser dye • High-grade industrial paints • Solvent industrial coatings applications for packaging • Arts and crafts • Powder coatings • Automotive • Toner • Inkjet • Publication • Metal decoration paint • Dyeing of polypropylene and polyamide yarns • Lacquers • Varnishes • Bodywork repair • Watercolors • Acrylic paints Other • Coloring plastics and rubber • Odor agents • Cleaning/washing agents • Surface treatment • Absorbents and adsorbents • Laboratory chemicals • Pharmaceuticals • Light-harvesting material • Transistor • Molecular switches • Solar cell • Optoelectronic device • Paper • Architectural • Polyester fibre • Adhesion • Motors, generators, vehicle components • Sporting goods • Appliances • Agricultural equipment • Oil and gas pipelines Page 11 of 17 ------- Use at Industrial Sites PV29 is primarily used as a pigment at industrial sites in the U.S. (CDR 2012) Commercial Uses According to information submitted to EPA for the 2012 CDR period, PV29 is used in: • Plastic and rubber products • Paints and coating In EPA's Chemical and Product Categories (CPCat) database, uses described for PV29 include: • Paints • Lacquers • Varnishes • Motor vehicle paints • Bodywork repair (https://actor.epa.gov/cpcat/faces/search.xhtml) Consumer Uses Watercolor and acrylic paints for art are the only consumer products that the EPA is aware of at the present time with PV29. Past and Potential Uses Current International Uses of PV29: EPA's Aggregated Computational Toxicity Online Resources (AcTor) database, includes the following international use information: • Sale maintenance and repair of motor vehicles and motorcycles (Denmark) • Wholesale retail trade and repair (Denmark) • Odor agents (Denmark) • Cleaning/washing agents (Norway and Denmark) • Surface treatment (Norway and Denmark)) • Absorbents and adsorbents (Denmark) • Paints lacquers and varnishes (Denmark) • Laboratory chemicals (Finland) • Pharmaceuticals (Finland) (https://actor.epa.gov/actor/chemical.xhtml?casrn=81-33-4) Page 12 of 17 ------- USEFUL TYPES OF INFORMATION This document presents a summary of information currently available to EPA on this chemical. To more fully characterize the manufacturing, processing, distribution, disposal, and use of this chemical, and to inform the development of the scoping document for this chemical, EPA is interested in obtaining information on: • the functional uses for this chemical; • what types of products contain this chemical; • which industry sectors use this chemical; • what volume of the chemical is used; • which uses have been discontinued or phased out; • exposure scenarios for this chemical; and • in which articles this chemical is found. Page 13 of 17 ------- APPENDIX: SOURCES CONSULTED • U.S. EPA Chemical Inventory https://www.epa.gov/tsca-inventory • U.S. EPA ChemView https://iava.epa.gov/chemview • TRI P2 information https://www.epa.gov/toxics-release-inventorv-tri-program/pollution-prevention-p2-and-tri • U.S. EPA HPV HC (access through Chemical Data Access Tool - CDAT) https://java.epa.gov/oppt chemical search/ • U.S. EPA HPVIS and HPV HC (access through Chemical Data Access Tool - CDAT) https://java.epa.gov/oppt chemical search/ • DfE Alternatives Assessments https://www.epa.gov/saferchoice/design-environment-alternatives-assessments • Safer Chemical Ingredients List https://www.epa.gov/saferchoice/safer-ingredients • Green Chemistry awards https://www.epa.gov/greenchemistry/presidential-green-chemistry-challenge-winners • Greener products and services https://www.epa.gov/greenerproducts/identify-greener-products-and-services • Pollution Prevention https://www.epa.gov/p2/pollution-prevention-case-studies https://www.epa.gOv/p2/grant-programs-pollution-prevention#sra https://www.epa.gov/p2/pollution-prevention-tools-and-calculators • U.S. EPA InertFinder https://iaspub.epa .gov/apex/pesticides/f?p=101:l: • U.S. EPA Pesticide Chemical Search https://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:l:0::NO:l:: • U.S. EPA Endocrine Disruptor Screening Progmrn https://www.epa.gov/ingredients-used-pesticide-products/endocrine-disruptor-screening- program-tier-l-assessments • U.S. EPA Hgzgrdous Wgste https://www.epa.gOv/hw/learn-basics-hazardous-waste#regulations • U.S. EPA Superfund chemicgl dgtg mgtrix https://www.epa.gov/superfund/superfund-chemical-data-matrix-scdm-query • U.S. EPA Hgzgrdous Air Pollutgnts https://www.epa.gov/haps/initial-list-hazardous-air-pollutants-modifications • U.S. EPA Significgnt New Alterngtives Policy (SNAP) https://www.epa.gov/snap • U.S. EPA Volgtile Orggnic Compounds https://www.epa.gov/indoor-air-qualitv-iaq/technical-overview-volatile-organic- compounds#definition • U.S. EPA Toxic gnd priority pollutgnts under the Clegn Wgter Act https://www.epa.gOv/eg/toxic-and-priority-pollutants-under-clean-water-act#toxic Page 14 of 17 ------- • U.S. EPA Contaminant Candidate list under the Safe Drinking Water Act https://www.epa.gOv/ccl/contaminant-candidate-list-3-ccl-3#chemical-list • U.S. EPA IRIS Assessment https://cfpub.epa.gov/ncea/iris2/atoz.cfm • U.S. EPASffS https://iaspub.epa.gov/sor internet/registry/substreg/searchandretrieve/substancesearch/search. do • U.S. EPA Chemical and Product Categories (CPCat) Database https://actor.epa.gov/cpcat/faces/home.xhtml • U.S. National Library of Medicine ChemlDplus https://chem.sis.nlm.nih.gov/chemidplus/ • U.S. National Library of Medicine Hazardous Substance Data Bank (HSBD) https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm • U.S. Department of Health & Human Services Household Products Database https://hpd.nlm.nih.gov/index.htm • OSHA Chemical Hazards and Toxic Substances https://www.osha.gov/SLTC/hazardoustoxicsubstances/index.html • NIOSH Workplace Safety and Health Topics Chemicals http://www.cdc.gov/niosh/topics/chemical.html • NIOSH Pocket Guide to Chemical Hazards http://www.cdc.gov/niosh/npg/npgdcas.html • CPSC Chemicals http://www.cpsc.gov/en/Research--Statistics/Chemicals/ • CPSC FHSA https://www.cpsc.gov/Business--Manufacturing/Business-Education/Business-Guidance/FHSA- Requirements/ • Food and Drug Administration List of Databases http://www.fda.gov/Forlndustrv/FDABasicsforlndustry/ucm234631.htm • NTP (National Toxicology Program) Substances studied by NTP http://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status • Department of Energy Protective Action Criteria Database http://energy.gov/ehss/protective-action-criteria-pac-aegls-erpgs-teels-rev-29-chemicals-concern- may-2016 • California Department of Toxic Substances Control Toxics in Products http://www.dtsc.ca.gov/PollutionPrevention/ToxicslnProducts/index.cfm http://www.dtsc.ca.gov/SCP/CandidateChemicalsList.cfm http://www.dtsc.ca.gov/SCP/WhatlsAPriorityProduct.cfm • California Office of Environmental Health Hazard Assessment Proposition 65 http://oehha.ca.gov/proposition-65/chemicals http://oehha.ca.gov/proposition-65/proposition-65-list • California Office of Environmental Health Hazard Assessment Biomonitoring http://biomonitoring.ca.gov/chemicals • California permissible exposure limits for chemical contaminants https://www.dir.ca.gov/title8/5155table acl.html Page 15 of 17 ------- • California hazardous substance list https://www.dir.ca.gov/title8/339.html • California Safe Cosmetics Program - list of chemical agents known or suspected to cause cancer or developmental or other reproductive harm. http://www.cdph.ca.gov/programs/cosmetics/Pages/default.aspx https://safecosmetics.cdph.ca.gov/search/Default.aspx • Maine chemicals of high concern http://www.maine.gov/dep/safechem/highconcern/ • Massachusetts Toxics Use Reduction Act (TURA) (link includes a link to Higher hazard substances list) http://www.mass.aov/eea/waste-mant-recyclina/toxics/toxic-use-reduction/toxics-use-reduction- act/ • Massachusetts Complete list of TURA chemicals http://www.mass.gov/eea/agencies/massdep/toxics/tur/toxics-use-reduction-act-tura-reporting- and-fees.html • Lowell Center for Sustainable Production Chemical, Policy and Science Initiative http://www.chemicalspolicv.org/chemicalspolicy.us.state.database.php • Minnesota Department of Health Toxic Free Kids Act Chemicals of High Concern http://www.hea lth.state.mn.us/d ivs/eh/hazardous/topics/toxfreekids/highconcern.html • Michigan Environmental Health Topics http://www.michigan.gOv/mdhhs/0.5885.7-339-71548 54783 54784 74881-13050~.00.html • New Hampshire Regulated Toxic Air Pollutants http://des.nh.gov/organization/commissioner/legal/rules/documents/env-al400.pdf • New Jersey Right to Know Hazardous Substances http://web.doh.state.ni.us/rtkhsfs/rtkhsl.aspx • Oregon Priority Persistent Pollutants (in water) http://www.deq.state.or.us/wq/SB737/ • Oregon Pollutant Profiles http://www.deq.state.or.us/wq/SB737/docs/LegRpAtt420100601.pdf • Oregon Reducing Toxics in Oregon http://www.oregon.gov/deq/Pages/ToxicsReduction.aspx • Oregon Chemicals of Concern for Children's Health http://public.health.oregon.gov/HealthvEnvironments/HealthyNeighborhoods/ToxicSubstances/Pa ges/childrens-chemicals-of-concern.aspx • Pennsylvania Department of Labor and Industry Hazardous Substance List http://www.pacode.com/secure/data/034/chapter323/chap323toc.html • Rhode Island Air Resources - Air Toxics http://www.dem.ri.gov/pubs/regs/regs/air/air22 08.pdf • Vermont Chemical Disclosure Program for Children's Products http://www.healthvermont.gov/enviro/chemical/cdp.aspx • Washington Chemicals of High Concern to Children http://www.ecy.wa.gov/programs/hwtr/rtt/cspa/chcc.html • Washington Children's Safe Products Act http://apps.leg.wa.gov/RCW/default.aspx?cite=70.240 Page 16 of 17 ------- • Washington Department of Labor & Industries SHARP Publications http://www.lni.wa.gov/Safety/Research/Pubs/default.asp • National Conference of State Legislatures http://www.ncsl.org/research/environment-and-natural-resources/state-chemical-statutes.aspx • Canada Chemicals Portal http://chemicalsubstanceschimiques.gc.ca/index-eng.php • EU ECHA website https://echa.europa.eu/ • Australia NICNAS Chemical Information https://www.nicnas.gov.au/chemical-information • Japan Chemical Risk Information Platform (CHIRP) http://www.nite.go.jp/en/chem/chrip/chrip search/systemTop • OECD eChemPortal http://www.echemportal.org/echemportal/index?pagelD=Q&request locale=en • Stockholm Convention on Persistent Organic Pollutants http://chm.pops.int/TheConvention/ThePOPs/ListingofPOPs/tabid/25Q9/Default.aspx http://chm.pops.int/TheConvention/ThePOPs/ChemicalsProposedforListing/tabid/251Q/Default.as • WHO IPCS (UN) http://www.who.int/ipcs/en/ • Other - worker protection information http://www.dguv.de/ifa/gestis/gestis-internationale-grenzwerte-fuer-chemische-substanzen-limit- values-for-chemical-agents/index-2.jsp • DeLima Associates Consumer Product Information Database (CPID) https://www.whatsinproducts.eom/chemicals/index/l • SRC FatePointers Search Module PHYSPROP http://esc.syrres.com/fatepointer/search.asp • Product and company websites Page 17 of 17 ------- |