Risk Evaluation for N-Methylpyrrolidone (2-Pyrrolidinone, 1-Methyl-) Systematic Review Supplemental File: Data Quality Evaluation of Environmental Release and Occupational Exposure Data CASRN: 872-50-4


PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
xvEPA
United States
Environmental Protection Agency
Office of Chemical Safety and
Pollution Prevention
Risk Evaluation for
N-Methylpyrrolidone
(2-Pyrrolidinone, 1-Methyl-)
Systematic Review Supplemental File:
Data Quality Evaluation of
Environmental Release and Occupational Exposure Data
CASRN: 872-50-4
October 2019

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
This document is a compilation of tables for the data extraction and evaluation for
N-Methylpyrrolidone (NMP). Each table shows the data point or set or information
element that was extracted and evaluated from a data source in accordance with Appendix D
of the Application of Systematic Review in TSCA Risk Evaluations. If the source contains more
than one data set or information element, the review provides an overall confidence score for
each data set or information element that is found in the source. Therefore, it is possible
that a source may have more than one overall quality/confidence score.
Table of Contents
Releases to the Environment
Occupational Exposure
Facility
Page
3
61
441
Explanatory Notes
These explanatory notes provide context to understand the short comments in the data evaluation tables.
Domain
Metric
Description of Comments Field
Reliability
Methodology
Indicates the sampling/analytical methodology, estimation method, or
type of publication
Repre sentativene ss
Geographic Scope
Indicates the country of the study, publication, or underlying data
Applicability
Indicates whether the data are for a condition of use within scope of the
Risk Evaluation
Temporal Representativeness
Provides the year of study, publication, or underlying data
Sample Size
Describes the distribution of the sample or underlying data
Accessibility / Clarity
Metadata Completeness
Describes the completeness of the metadata
Variability and Uncertainty
Metadata Completeness
Indicates if study or publication addresses variability and uncertainty of
the data or information
2

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Releases to the Environment
3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Solomon, G. M.,Morse, E. P.,Garbo, M. J.,Milton, D. K.. 1996. Stillbirth after occupational exposure to N-methyl-2-
pyrrolidone: A case report and review of the literature. Journal of Occupational and Environmental Medicine.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3043623
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Environmental Media:
Release or Emission Factor:
Daily Release Quantity (kg/day):
Number of Sites:
Use
laboratory
Laboratory waste
hazardous waste
hazardous waste
100 percent released
1 L/day
1
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
From an industry contact
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Use is in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996 - more than 20 years old
Metric 5:
Sample Size
Medium
x 1
2
Information is from one source
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Kim, B. R.,Kalis, E. M.,Dewulf, T.,Andrews, K. M.. 2000. Henry's law constants for paint solvents and their implications on
volatile organic compound emissions from automotive painting. Water Environment Research.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3578170
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Release or Emission Factor:
Release Estimation Method:
Annual Release Quantity (kg/yr)
Number of Sites:
Use
painting
During painting, overspray paint materials are captured in continuously
recirculating scrubber water and stored in a sludge pit. Periodically or
continually (depending on operating conditions of an assembly plant),
captured paint material (paint sludge) is separated from scrubber water
and sent to a landfill. Spent scrubber water that contains VOCs is peri-
odically discharged to a municipal wastewater treatment plant. At some
assembly plants, a portion of VOCs in the exhaust air is captured and
destroyed using vapor-phase adsorption followed by thermal oxidation
before the air is emitted to the atmosphere.
Wastewater, incineration
80 percent of the PV (9700 kg/yr) is released in scubber wastewater
Measured
7700 kg/yr in scubber wastewater
1
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
Does not cover all releases at the site
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Use is in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized. Sam-
pie size is sufficiently representative (11 samples)
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
Lacks release frequency
Continued on next page
5

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Kim, B. R.,Kalis, E. M.,Dewulf, T.,Andrews, K. M.. 2000. Henry's law constants for paint solvents and their implications on
volatile organic compound emissions from automotive painting. Water Environment Research.
Releases to the Environment; Environmental Release Data;
3578170
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Medium x 1	2 limited discussion
Overall Quality Determination^
Medium
1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Releases to the Environment; Environmental Release Data;
3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr)
Processing
Formulation of adhesive
Wash water from formulation equipment will be re-used in subsequent
batches where possible. Otherwise, it will be treated on site and sludge
disposed of to landfill. 50 percent of the wash water will be re-used
in subsequent batches and the remainder released into the sewer. An
estimated 100 kg of the notified polymer will be lost to landfill as residues
in the empty import drums each year.
WWT
Landfill, Water
Estimated by formulation and use company
For polymer in formulation (polymer is 35 percent ; NMP is 5 percent
) = 45 kg/yr (landfill from WWT); 5 kg/yr (water from WWT); 100
kg/yr (landfill from empty drums)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Likley to cover all releases
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
Use is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2001
Metric 5:
Sample Size
Low
x 1
3
Not characterized
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
data include all associated metadata
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Continued on next page
7

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3978357
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
8

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Releases to the Environment; Environmental Release Data;
3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr)
Use
Spray application of adhesive
The notifier estimates that approximately one third of the formulation
will be lost as overspray. Of this, 50 percent will be trapped in the
spray both water reservoir and 50 percent will be removed by the scrub-
ber unit. All other dry wastes generated during the application of the
basecoat, including the waste obtained from the periodic cleaning of
scrubber baffles and filters will also be disposed of in landfill.
WWT
Landfill, Water
Estimated by formulation and use company
For polymer in formulation (polymer is 35 percent ; NMP is 5 percent )
= 6.6 tonnes/yr (WWT)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Likley to cover all releases
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
Use is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2001
Metric 5:
Sample Size
Low
x 1
3
Not characterized
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
data include all associated metadata
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Continued on next page
9

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Releases to the Environment; Environmental Release Data;
3978357

EVALUATION
Domain
Metric Rating MWF* Score
Comments
Overall Quality Determination^ Medium 1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
10

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3982074
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Release or Emission Factor:
Daily Release Quantity (kg/day):
Number of Sites:
Use
immersion degreasing
solvent dragout
dragout
1.94 grams/lb of parts cleaned
912 g/day (114 g/hr for 8 hrs)
1
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
may not cover all release sources at the site
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1993
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks release frequency
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Medium
2.1
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
11

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3982074
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Annual Release Quantity (kg/yr):
Number of Sites:
Use
immersion degreasing
Evaporative losses during operation. Total bath solvent surface area is
10 in. x 24 in.
air
10.96 grams/hour
1
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
may not cover all release sources at the site
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1993
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks release frequency
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Medium
2.1
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
12

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-
Methylopyrrolidone (NMP).
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3827468
EXTRACTION
Parameter
Data

Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Environmental Media:
Annual Release Quantity (kg/yr):
Number of Sites:
Disposal
all
landfill, other land disposal facilities, air, surface water, UIC wells
3,043,625 lbs to landfill and/or other trmt/disp facilities (2,789,548 lbs to
landfill or UIC wells, 254,077 lbs to other); 5,063,992 lbs. were disposed
or released on site (3,623,299 lb to UIC wells, 1,440,593 lbs to fugitive
air and surface water)
389 (2015 TRI)
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1
From trusted sources
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
High
Low
X 1
x 2
x 2
x 1
1
2
2
3
US
in scope
2017
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
13

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3828838
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
All
all
Releases to air from various generic unit operations, valves and other
attachements. Residuals in drums and tanks
air, uncertain
Average emission factors for unit operations are in Table 7.1. Emis-
sion factors for fugitive emissions from valves, etc. in Table 7.2. Drum
residual LF in Table 7.3.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Medium
High
Low
X 1
x 2
x 2
x 1
2
4
2
3
OECD
Generic information that can be applied to in-scope uses
2011
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
Medium

1.7

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2016. Toxic release inventory: N-methyl-2-pyrrolidone.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3860464
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Annual Release Quantity (kg/yr):
All
all
all releases from TRI from NMP
Underground injection well, landfill, fugitive air, stack air, surface water,
UIC wells, other land impoundments
TRI release quantities for the year 2014 are compiled in the document
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Expected to cover all releases
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Low
X 1
x 2
x 2
x 1
1
2
2
3
US
in scope
2014
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
all metadata necessary
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
15

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3860493
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Use
petrochemical processing aid?
wastewater effluent
POTW
0, 33.7, 66.3 ug NMP/L wasteawater
3 measurements taken at petrochemcial plant
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Does not cover all releases at the site
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
High
X 1
x 2
x 2
x 1
1
2
6
1
US
in scope
1996-1997
3 samples, all results given
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

2.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
16

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Atsdr,. 2015. Health consultation: Review of air quality data: Intel Corporation " New Mexico facility: Rio Rancho, Sandoval
County, New Mexico: EPA facility ID: NMD000609339, Part 2.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3970460
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr):
Use
electronics - photoresist remover?
unknown - based on company process operations, NMP was likely used
as a photoresist remover in the 1990s and the facility switcehd to a
different solvent in the 2000s
Air
TRI 1987-2013
>9,000 lb in 1995; 0 pounds in 2013
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Does not cover all releases at the site
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1987-2013
Metric 5:
Sample Size
Medium
x 1
2
range provided in bar graph
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
17

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nicnas,. 1997. Full public report: Polymer in byk-410.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3978356
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Annual Release Quantity (kg/yr):
Processing
coating /paint formulation
release of polymer-NMP coating additive during formulation is estimated
to be no more than 2 percent total. Incorporates all sources of release,
all
2 percent
information from one formulation company
55 kg/yr of polymer_NMP soln based on annual use rate of 2750 kg.yr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Likely to cover all releases
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1997
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium
2.2
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
18

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Releases to the Environment; Environmental Release Data;
3978358
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Annual Release Quantity (kg/yr)
Use
Coating /additive in Papermaking
release to the environment may potentially occur from: leaking storage
containers (less than 2 percent ); accidental spills (less than 1 percent
); during application (less than 10 percent ) and disposal of residual
material in containers (less than 5 percent ). The worst case total of
20 percent released during the application to paper, corresponds to a
maximum of 500 kg per annum at the maximum rate of import,
all
10 percent
information from one papermaking company
500 kg/yr of polymer-NMP soln based on annual import rate of 2,500
kg
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Likely to cover all releases
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
This was not identified as a use by EPA, but no uses are ex-





cluded from scope. May be applicable to coating OES?
Metric 4:
Temporal Representativeness
Low
x 2
6
1998
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Release data include release media and source, but not fre-





quency of release
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Continued on next page
19

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3978358
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	2.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
20

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Releases to the Environment; Environmental Release Data;
3978358
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Use
architectural (concrete) coating
Release to the environment resulting from the use of the polymer as a
concrete coating may occur to the sewer (washing of tools used to apply
formulations containing the notified chemical), or to landfill (disposal of
residual quantities of the formulations within used containers). Over-
spray or splatter from rollers or brushes (These releases are likely to
remain where they fall, mainly on the ground.)
Sewer; landfill
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Likely to cover all releases
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Low
N/A
X 1
x 2
x 2
2
2
6
N/A
Australia
in scope
1998
This metric is not applicable to this data element
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Release data include release media abd source, but not fre-
quency of release
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium
2.0
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
21

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Erg,. 2000. Preferred and alternative methods for estimating air emissions from paint and ink manufacturing facilities.
Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
3982076
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
P2 Control & percent Efficiency:
Processing
Paint and ink formulation
material loading, heat-up losses, equipment leaks, spills, surface evapo-
ration, liquid material storage, WWT
Fugitive air emissions from the listed release sources
Provides examples of calculating emissions based on emission factors
from AP-42, source-specific models, and mass balances.
AP-42 and models (not NMP-specific)
Removal equipment available for treating VOC-containing air streams
includes recovery devices (i.e., carbon adsorption, absorption, and con-
densation) and combustion devices (i.e., thermal incinerators, catalytic
incinerators, and industrial boilers and process heaters). Control effi-
ciencies for this equipment can range from 50 to 99 percent, but are
most typically greater than 95 percent (EIIP, 2000). Carbon adsorbers,
absorbers (scrubbers), condensers, and catalytic incinerators are gener-
ally not appropriate for paint and ink manufacturing facilities. Industrial
and process heaters are capable of effectively treating the types and lev-
els of VOCs generated by the paint and ink industry but are found in
few, if any, paint and ink manufacturing facilities (EPA, 1992a).
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
From trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data element
Continued on next page
22

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Erg,. 2000. Preferred and alternative methods for estimating air emissions from paint and ink manufacturing facilities.
Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
3982076
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1 1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1 1
well characterized
Overall Quality Determination^
High 1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
23

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Mo, D. N. R.. 2001. State of Missouri toxics release inventory: Summary report: 1999 data.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3982077
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr):
Use
paints and adhesives used in the transportation equipment MFG sector
air emissions
Air
1999 TRI data for the state of Missouri
83,500 kg/yr (in 1999 in Missouri)
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Expected to cover all releases
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
1999
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

1.9

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Mo, D. N. R.. 2001. State of Missouri toxics release inventory: Summary report: 1999 data.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3982077
EXTRACTION
Parameter
Data
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr):
Unknown - emission data provide per company name (based on names,
may include: wire coating, car painting, lab, solvent mfg, cement coat-
ing)
unknown - TRI data
Air, POTW, WWT, landfill, energy recovery
1999 TRI data for the state of Missouri
see App C and G for site specific TRI emissions
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Expected to cover all releases
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Medium
x 2
4
Data may include info on in-scope uses, but cannot be deter-

mined without searching company names
Metric 4:
Temporal Representativeness
Medium
x 2
4
1999
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

2.1

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Technikon, L. L. C.. 2001. Core box cleaner study: Evaporative emission study of specialty systems' solvent FC-47-G1.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982183
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Use
cleaning of casts /molds and hoppers in foundry applications
Study on the rate of evaporation of cleaning solution containing NMP
at unknown concentration
Fugitive air
0.00004 g of solvent soln/sec (see Fig 12 - 16)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
High quality techniques
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
High
X 1
x 2
x 2
x 1
1
2
4
1
US
in scope
2001
Fully characterized with multiple figures and charts
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High
1.2
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
26

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Chemistry Industry Association of, Canada. 2017. All substances emissions for 2012 and projections for 2015.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3982361
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Annual Release Quantity (kg/yr):
Use
Assumed = Paint formulation; Chemical Formulation
Source lists NMP emissions from sites in Canada. Source does not list
the operations that occur at the sites. Assumed life cycle descriptions
based on the names of the facilitites.
Air
0.1 tonnes/yr (2012)
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X
1
3
Methodology is not specified
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X
1
2
Canada
Metric 3:
Applicability
Medium
X
2
4
The operations at these sites are not characterized. Assumed

to likely be in scope, but unnknown,
Metric 4:
Temporal Representativeness
High
X
2
2
2012
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Low
X
1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
The release data study does not address variability or uncer-

tainty.
Overall Quality Determination^
Medium
2.2
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
27

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Chemistry Industry Association of, Canada. 2017. All substances emissions for 2011 and projections for 2014.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3982362
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Annual Release Quantity (kg/yr):
Use
Assumed = Paint formulation; Chemical Formulation
Source lists NMP emissions from sites in Canada. Source does not list
the operations that occur at the sites. Assumed life cycle descriptions
based on the names of the facilitites.
Air
0.05 tonnes/yr (2011)
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X
1
3
Methodology is not specified
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X
1
2
Canada
Metric 3:
Applicability
Medium
X
2
4
The operations at these sites are not characterized. Assumed

to likely be in scope, but unnknown,
Metric 4:
Temporal Representativeness
High
X
2
2
2011
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Low
X
1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
The release data study does not address variability or uncer-

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Turner, S. L.,McCrillis, R. C.. 2017. Evaluation of alternative chemical strippers on wood furniture coatings.
Releases to the Environment; Environmental Release Data;
3986887
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Use
Paint stripper
VOC emissions during stripping
fugitive air
158.94 to 263.74 g VOC /m2 substrate surface
VOC from stripping solutions containing NMP (solutions 2, 3, 4 in the
study)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
The release data methodology is known or expected to be accu-
rate (e.g., trusted source) but may not cover all release sources
at the site
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
Low
X 1
x 2
x 2
x 1
1
2
6
3
US
in scope
no date
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Release data include release media but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The release data study does not address variability or uncer-
tainty.
Overall Quality Determination^
Medium
2.2
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
29

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Campbell, H. L.,Striebig, B. A.. 1999. Evaluation of N-methylpyrrolidone and its oxidative products toxicity utilizing the
microtox assay. Environmental Science and Technology.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3566019
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
P2 Control & percent Efficiency:
All
all
Study on the toxicity of byproducts from the oxidation of NMP in
wastewater.
Countercurrent wet scrubber was utilized to transfer the NMP vapor to
the aqueous phase. The scrubber utilized water as the scrubbing liquor
and removed greater than 97 percent of the NMP from the exhaust air
stream at the facility
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
The assessment or report uses high quality data and/or tech-

niques that are not from trusted sources; however, Associated

information does not indicate flaws or quality issues.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Medium
x 2
4
Applicable to in-scope uses; but, information is on toxicity

which is not used by engineering assessors (is used by exposure

assessors)
Metric 4:
Temporal Representativeness
Medium
x 2
4
1999
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x
1 2
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x
1 2
limited discussion

Continued on next
page

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Campbell, H. L.,Striebig, B. A.. 1999. Evaluation of N-methylpyrrolidone and its oxidative products toxicity utilizing the
microtox assay. Environmental Science and Technology.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3566019
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

Medium 2.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
31

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X
1
3
The release data methodology is not specified.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable
4 Metric Mean Score: 2.0.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
32

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
PhotographicFilm, Paper,Plate, andChemicalManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.0.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
33

Parameter
Data
Life Cycle Stage: Processing
Life Cycle Description (Subcategory of Use): AllOtherMiscellaneousChemicalProduct andPreparationManufacturing
Annual Release Quantity (kg/yr): see release rates in report
Number of Sites: 1
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X
1
3
The release data methodology is not specified.
Domain 2: Representative

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^ Unacceptable 4 Metric Mean Score: 2.0.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
34

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Plastic Material andResinManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
AllOther MiscellaneousManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
CementManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Disposal
HazardousWasteTreatment andDisposal
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
BatteryManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
AllOther BasicOrganicChemicalManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Distribution
OtherChemical andAllied ProductsMerchantWholesalers
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
Semiconductorand Related DeviceManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Pesticide andOtherAgriculturalChemicalManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Adhesive Manufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
OtherMiscellaneousGeneralPurposeMachineryManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Disposal
AllOtherMiscellaneousWasteManagementServices
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
MotorVehicleSeating andlnterior TrimManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
FabricCoating Mills
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
UnlaminatedPlastics Filmand Sheet(except Packaging)Manufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
OtherCommunicationand EnergyWireManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
OtherElectronicComponentManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Medicinal andBotanicalManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
Printing InkManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
OphthalmicGoodsManufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Polishand OtherSanitationGoodManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Pharmaceutical PreparationManufacturing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Use
Leather andHide Tanningand Finishing
see release rates in report
1
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Low X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Pollution prevention search results, envirofacts database.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID 3860453
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Annual Release Quantity (kg/yr):
Number of Sites:
Processing
Urethane andOther FoamProduct(exceptPolystyrene)Manufacturing
see release rates in report
1
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X 1 3 The release data methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2008-present
Metric 5:
Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Unacceptable
X
1
4
has no release media or other information
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
X
1
3
No discussion
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Basf,. 1998. N-methylpyrrolidone(NMP): Biodegradability.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982075
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Waste Treatment Method:
All
All
Information on the biodegradability of NMP and use of WWT to treat/
remove NMP from wastewaters
WWTP
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
Low
N/A
X 1
x 2
x 2
1
4
6
N/A
US
Information is not related to a life cycle stage, but is broadly
applicable
1998
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources, assessment methods, re-
sults, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
59

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Disposal /Treatment Method:
Release or Emission Factor:
Annual Release Quantity (kg/yr):
Release Days per Year:
Processing
Paint and coating removers
Paint strippers
Sent to Wastwater treatment
0.07 kg/site-day
2500 - 3770
250.0
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
Manufacturing in scope
1989
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
60

-------
PEER REVIEW DRAFT
Occupational Exposure
DO NOT CITE OR QUOTE
61

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nishimura, S.,Yasui, H.,Miyauchi, H.,Kikuchi, Y.,Kondo, N.,Takebayashi, T.,Tanaka, S.,Mikoshiba, Y.,Omae, K.,Nomiyama,
T.. 2009. A cross-sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Industrial
Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	735269
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Use
cleaning of instruments
vapor
Inhalation
0.14-0.26 ppm (mean); 0.8 ppm (max)
70.0
1.0
full-shift
all activities during a day
14
personal
8 hrs
5 days/wk
Noneof the NMP-exposed workers wore any protective respiratoryde-
vices or clothing. All wore disposable, thin protectivegloves made of
polyethylene
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Methodology is explained and seems legitimate
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Japan
Metric 3:
Applicability
High
x 2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2009
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized.
Domain 3: Accessibility/Clarity
Continued on next page
62

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Nishimura, S.,Yasui, H.,Miyauchi, H.,Kikuchi, Y.,Kondo, N.,Takebayashi, T.,Tanaka, S.,Mikoshiba, Y.,Omae, K.,Nomiyama,
T.. 2009. A cross-sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Industrial
Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	735269
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Metric 6: Metadata Completeness
Medium
X 1
2
Lacks worker actitities and whether its TWA
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
63

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Haufroid, V.,Jaeger, V. K.,Jeggli, S.,Eisenegger, R.,Bernard, A.,Friedli, D.,Lison, D.,Hotz, P.. 2014. Biological monitoring and
health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study. International Archives of Occupational
and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	2654929
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Use
graffiti removal or throughother uses of NMP
vapor
Inhalation
0.18 (mean), 0.89 (75th), 2.77 (90th), and 25.83 (Max) mg/m3
91.0
21.0
full-shift
graffiti removal or other activities associated with the life cycle
91
personal
310525 min
varies
Suitable masks, butyl or latex gloves
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Airborne NMP was determined according to the NIOSH





method.
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Multiple European Countries
Metric 3:
Applicability
High
x 2
2
All described conditions of use are in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2006-2011
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks worker actitities and whether its TWA
Continued on next page
64

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Haufroid, V.,Jaeger, V. K.,Jeggli, S.,Eisenegger, R.,Bernard, A.,Friedli, D.,Lison, D.,Hotz, P.. 2014. Biological monitoring and
health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study. International Archives of Occupational
and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	2654929
EVALUATION


Domain Metric
Rating
MWF* Score Comments
Domain 4: Variability and Uncertainty


Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
65

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Solomon, G. M.,Morse, E. P.,Garbo, M. J.,Milton, D. K.. 1996. Stillbirth after occupational exposure to N-methyl-2-
pyrrolidone: A case report and review of the literature. Journal of Occupational and Environmental Medicine.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3043623
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Number of Workers:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Use
Laboratory
vapor
Inhalation
0.2 mg/m3
2-hour	short term
15
personal and area
Average of 42 hours each week
3-4	days/wk
LEV over the spectrophotometers, but there was no LEV over the coun-
tertop, on which the patient filtered the NMP
half-face air-purifying respirator, coat, safety goggles, and latex gloves
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
Low
X 1
x 2
x 2
x 1
1
2
6
3
US
This use is in scope
1996 - more than 20 years old
Distribution not characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Lacks worker actitities and whether its TWA
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Continued on next page
66

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Solomon, G. M.,Morse, E. P.,Garbo, M. J.,Milton, D. K.. 1996. Stillbirth after occupational exposure to N-methyl-2-
pyrrolidone: A case report and review of the literature. Journal of Occupational and Environmental Medicine.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3043623
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

Medium 2.0


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
67

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Belanger, P. L.,Coye, M. J.. 1983. Health Hazard Evaluation Report No. HETA-79-129-1350, San Francisco Newspaper
Agency, San Francisco, California.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3101190
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Use
Printing
particulate
Inhalation
0.12 - 3.29 mg/m3
43.0
1.0
full-shift TWA
personal
5.17 - 7.92 hours
EVALUATION



Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability



Metric 1:
Methodology
High
X 1 1 Sampling or analytical methodology is an approved OSHA or



NIOSH method
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High	x 1	1	US
Medium	x 2	4	in scope, but data is not NMP-specific (i.e., surrogate data)
Low	X 2	6	1983
High	X 1	1	Fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Fully characterized
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2 Some discussion
Overall Quality Determination^
Medium
1.8
Continued on next page
68

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Belanger, P. L.,Coye, M. J.. 1983. Health Hazard Evaluation Report No. HETA-79-129-1350, San Francisco Newspaper
Agency, San Francisco, California.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3101190
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
69

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Belanger, P. L.,Coye, M. J.. 1983. Health Hazard Evaluation Report No. HETA-79-129-1350, San Francisco Newspaper
Agency, San Francisco, California.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3101190
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Use
Printing
particulate
Inhalation
0.27 - 0.68 mg/m3
5.0
1.0
partial shift
personal
3.33 - 3.58 hours
EVALUATION



Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability



Metric 1:
Methodology
High
X 1 1 Sampling or analytical methodology is an approved OSHA or



NIOSH method
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High	x 1	1	US
Medium	x 2	4	in scope, but data is not NMP-specific (i.e., surrogate data)
Low	X 2	6	1983
High	X 1	1	Fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Fully characterized
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2 Some discussion
Overall Quality Determination^
Medium
1.8
Continued on next page
70

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Belanger, P. L.,Coye, M. J.. 1983. Health Hazard Evaluation Report No. HETA-79-129-1350, San Francisco Newspaper
Agency, San Francisco, California.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3101190
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
71

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3539720
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Exposure Duration:
Use
cleaning of optical and metal parts
vapor
Inhalation
average = 2 mg/m3; max = 2.8 mg/m3
2.0
12-hr TWA
cleaning of optical and metal parts
12
personal
12 hr
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology High X 1 1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Japan
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2000
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1 2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1 3
The monitoring study does not address variability or uncer-
tainty.
Continued on next page
72

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

Medium 1.8


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
73

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Sweden
Metric 3:
Applicability
Medium
x 2
4
Similar to an occupational scenario within the scope of the risk

evaluation
Metric 4:
Temporal Representativeness
Low
x 2
6
1993-2001
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-

tain statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks certain metadata
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
Low
x 1
3
The monitoring study does not address variability or uncer-

tainty.
Continued on next page
74

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

Medium 2.2


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
75

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative

tain statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks certain metadata
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Continued on next page
76

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

High 1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
77

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2006
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Processing
adhesive formulation
vapor
Inhalation
0.2 mg/m3
1.0
8hr TWA
bottling and shipping department
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium x 1	2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
Continued on next page
79

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
80

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3539720
EXTRACTION
Parameter Data
Life Cycle Stage: Processing
Life Cycle Description (Subcategory of Use): adhesive formulation
Physical Form: vapor
Route of Exposure: Inhalation
Exposure Concentration (Unit): 0.9 to 2.8 mg/m3
Number of Samples: 3.0
Type of Measurement or Method: 8hr TWA
Worker Activity: Bottling/shipping worker
Type of Sampling: personal
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology High X 1 1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1 2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
Continued on next page
81

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
82

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3539720
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Processing
adhesive formulation
vapor
Inhalation
2.3 mg/m3
1.0
8hr TWA
Bottling/shipping - Maintenance and cleaning
personal
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology High X 1 1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1 2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
Continued on next page
83

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
84

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3539720
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Processing
adhesive formulation
vapor
Inhalation
5.9 mg/m3
1.0
short-term peak
Bottling/shipping - Maintenance and cleaning
personal
42 mins
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology High X 1 1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1 2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness High X 1 1 Discussion on variability and uncertainty of results
Continued on next page
85

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
86

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3539720
EXTRACTION
Parameter Data
Life Cycle Stage: Processing
Life Cycle Description (Subcategory of Use): adhesive formulation
Physical Form: vapor
Route of Exposure: Inhalation
Exposure Concentration (Unit): 3.4 to 6.6 mg/m3
Number of Samples: 2.0
Type of Measurement or Method: 8hr TWA
Worker Activity: production - stirrer cleaning
Type of Sampling: personal
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology High X 1 1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1 2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
Continued on next page
87

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
88

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative

tain statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks certain metadata
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Continued on next page
89

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
90

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EXTRACTION
Parameter	Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	adhesive formulation
Physical Form:	vapor
Route of Exposure:	Inhalation
Exposure Concentration (Unit):	15.5 mg/m3
Number of Samples:	1.0
Type of Measurement or Method:	8hr TWA
Worker Activity:	production - vessel cleaning
Type of Sampling:	personal
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Well described methods
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
X
2
4
2006
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium x 1	2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
Continued on next page
91

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
92

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative

tain statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks certain metadata
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Continued on next page
93

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
94

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Meier, S.,Schindler, B. K.,Koslitz, S.,Koch, H. M.,Weiss, T.,Kafferlein, H. U.,Bruning, T.. 2013. Biomonitoring of exposure
to N-methyl-2-pyrrolidone in workers of the automobile industry. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3539921
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Worker Activity:
Number of Workers:
PPE:
Use
Spray application of paint in the automotive industry
liquid, vapor
dermal, inhalation
Preparing the lacquers; Loading the spraying system; After drying the
panels in an enclosedarea within the spraying chamber, the panels were
finally released back into the open workspace. There, the panels were
wiped off, detached, and packed into boxes. Irregular activities included
disassembling and manually cleaning the nozzles, screws, nuts, and bolts
of the sprayers because the sprayers can get clogged. The cleaning pro-
cessincluded the use of pure solvent mixtures containing up to 100 per-
cent NMP.
14 (10 of 14 workers were wipers/packers of dried parts and were not
regularly exposed to NMP; 2 of 14 were cleaners of spraying parts and
had the highest concentration)
Workers were required to wear thin solvent-resistant gloves made out of
laminate. The gloves were used either alone or inside a second pair of
gloves made out of polychloroprene or nitrile, which helped improve the
grip. All gloves were discarded after a single use. Workers were also able
to voluntarily use filter masks or as needed.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2012
Continued on next page
95

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Meier, S.,Schindler, B. K.,Koslitz, S.,Koch, H. M.,Weiss, T.,Kafferlein, H. U.,Bruning, T.. 2013. Biomonitoring of exposure
to N-methyl-2-pyrrolidone in workers of the automobile industry. Annals of Occupational Hygiene.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3539921
EVALUATION
Domain
Metric
Rating
MWF* Score Comments

Metric 5: Sample Size
N/A
N/A This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X 1 1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 well characterized
Overall Quality Determination^
High
1.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
96

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3562767
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Use
degreasing optical lenses
vapor
Inhalation
Range = 0.09 to 0.69 ppm
20.0
1.0
full shift 12-hr TWA
Worker Activity:

all activities during
a day

Number of Workers:

4



Type of Sampling:

personal



Exposure Duration:

12 hr/dy



Exposure Frequency:

5 dy/wk



EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Japan
Metric 3:
Applicability
High
x 2
2
Degreasing is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks description of all worker activities
Domain 4: Variability and Uncertainty
Continued on next page
97

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3562767
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 7: Metadata Completeness	Low	X 1	3 The monitoring study does not address variability or uncer-
tainty.
Overall Quality Determination^	Medium	1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
98

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3562767
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Use
degreasing metal parts
vapor
Inhalation
Range = 0.04 to 0.59 ppm
8.0
1.0
full shift 12-hr TWA
Worker Activity:

all activities during
a day

Number of Workers:

8



Type of Sampling:

personal



Exposure Duration:

12 hr/dy



Exposure Frequency:

5 dy/wk



EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Well described methods
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Japan
Metric 3:
Applicability
High
x 2
2
Degreasing is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks description of all worker activities
Domain 4: Variability and Uncertainty
Continued on next page
99

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3562767
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 7: Metadata Completeness	Low	X 1	3 The monitoring study does not address variability or uncer-
tainty.
Overall Quality Determination^	Medium	1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
100

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source
Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID
3809440
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacturing
Life Cycle Description (Subcategory of Use):	Manufacturing
Worker Activity:	Exposure may arise from sampling, technical maintenance and cleaning
PPE:	LEV and gloves (APF 5, 80 percent )
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
N/A
X
X
X
1
2
2
3
2
2
N/A
Europe
in scope
2013
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High


1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
101

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Worker Activity:
Number of Workers:
PPE:
Processing
formulation
Tasks include liquid transfer operations to and from bulk storage/
IBCs (intermediate bulk containers)/drums/smaller containers, mixing
in batch or continuous operations, sampling and analysis, storage and
cleaning and maintenance operations
160,000 (coating), 98,000 (cleaning)
LEV and Respiratory Protective Equipment (RPE) are employed and
protective clothing is used
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
102

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter	Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	chemical production aid
Worker Activity:	Exposure may arise from sampling, technical maintenance and cleaning
PPE:	LEV and gloves (APF 5, 80 percent )
EVALUATION


Domain
Metric
Rating MWF* Score Comments
Domain 1: Reliability


Metric 1:
Methodology
High X 1 1 Information from trusted sources
Domain 2: Representative
Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High x 1	1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
103

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Worker Activity:
PPE:
Use
Coating application
Tasks include liquid transfer operations to and from bulk storage/IBCs/
drums/smaller containers, mixing in batch or continuous operations,
preparation for application, application by spraying, brushing, roller,
and dipping/immersion, film formation or within a fluidised bed system,
sampling and analysis, storage and cleaning and maintenance operations.
Protective clothing, gloves and RPE
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
104

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Worker Activity:
Number of Workers:
PPE:
Use
Cleaning
Activities arising from the use of cleaning products containing NMP
that could give rise to exposure include transfer from storage, pouring/
unloading from drums or containers, mixing/diluting prior to use, clean-
ing activities (spraying, brushing, dipping,) and associated cleaning and
maintenance of equipment.
3,400,000 (prof cleaning), 43,000 (optical cleaning), 1,080,000 (furniture
cleaning), 662,000 (paint and glaze removal?)
LEV and gloves (with training; APF20 95 percent )
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
105

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
All
any stage with closed-system transfers
Inhalation
0.04 to 12.39 mg/m3
Modelled using EasyTRA
closed-system transfers. Table B65
8 hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
106

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
Manufacturing
any stage with closed-system transfers
liquid, 100 percent
dermal
0.03 to 1.37 mg/kg bw/day
Modelled using EasyTRA
closed-system transfers. Table B65
8 hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
107

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
All
any stage with manual transfers
Inhalation
3.10 to 17.35 mg/m3
Modelled using EasyTRA
Charging and discharging, including scenarios with elevated tempera-
ture. Table B66
1 to 8 hrs
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
108

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
All
any stage with manual transfers
liquid, 100 percent
dermal
0.34 to 2.74 mg/kg bw/day
Modelled using EasyTRA
Charging and discharging, including scenarios with elevated tempera-
ture. Table B66
1 to 8 hrs
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
109

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
Processing
formulation
Inhalation
0.04 to 20.65 mg/m3
Modelled using EasyTRA
mixing and blending
8 hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
110

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
Processing
formulation
liquid, 100 percent
dermal
0.69 to 2.74 mg/kg bw/day
Modelled using EasyTRA
mixing and blending
8 hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
High
x 1
1
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination1
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
Ill

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Processing
adhesive formulation
Inhalation
same data as source 3539720
Measured
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
This use is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2006
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2 Lacks certain metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
112

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
spray application of substrate (coating, cleaner, etc.)
Inhalation
7.96 to 18.70 mg/m3
Modelled using Stoffenmanager and RISKOFDERM
4 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
113

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
spray application of substrate (coating, cleaner, etc.)
dermal
1.73 to 3.46 mg/kg bw/day
Modelled using Stoffenmanager and RISKOFDERM
4 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
114

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
roll /brush application of substrate (coating, cleaner, etc.
Inhalation
4.13 mg/m3
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
115

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
roll /brush application of substrate (coating, cleaner, etc.
dermal
5.49 mg/kg bw/day
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
116

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
dip application of substrate (coating, cleaner, etc.)
Inhalation
4.13 to 12.40 mg/m3
Modelled using EasyTRA
4 to 8 hr/day
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
117

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
dip application of substrate (coating, cleaner, etc.)
dermal
1.64 to 2.74 mg/kg bw/day
Modelled using EasyTRA
4 to 8 hr/day
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
118

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
screen printing plant
Inhalation
7.1 to 22.2 mg/m"
unknown
1.0
unknown
unknown
unknown
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Unacceptable
x 2
8
1988 - so different as to make outdated information unaccept-





able
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.1.
Continued on next page
119

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440

EVALUATION
Domain
Metric Rating MWF* Score
Comments

** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
120

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Analytic Method:
Use
paint stripping
Inhalation
up to 64 mg/m3
unknown
8-hr TWA
unknown
personal?
8 hr
note: in paint stripper RA
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
Medium
x 1
2
some statistics unknown
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
121

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Analytic Method:
Use
paint stripping
Inhalation
280 mg/m3
unknown
1-hr peak
unknown
personal?
1 hr
note: in paint stripper RA
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
Medium
x 1
2
some statistics unknown
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
122

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Analytic Method:
Use
graffiti removal
Inhalation
10 mg/m3
unknown
8-hr TWA
unknown
personal
8 hr
note: in paint stripper RA
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope with paint stripping?
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
Medium
x 1
2
some statistics unknown
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
123

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Analytic Method:
Use
paint stripping
Inhalation
0.82 to 4.1 mg/m3
unknown
unknown
unknown
unknown
unknown
note: in paint stripper RA
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Medium
Low
X 1
x 2
x 2
x 1
3
2
4
3
unknown
in scope
2004
characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
Medium

1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
124

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Occupational Exposure; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
all
tank cleaning
Inhalation
4.1 to 12.4 mg/m3
unknown
unknown
unknown
unknown
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
125

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Use
cleaning of instruments
Inhalation
same data as 735269
Measured
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Japan
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2009
Metric 5:
Sample Size
Medium
x 1
2
some statistics unknown
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.2
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
126

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Processing
polymer
Inhalation
air concentrations exceeding the DNEL of 5 mg/m3 by approximately
5-fold
unknown
Measured
during preparation and initiating of the production pr
both
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Medium
Low
X 1
x 2
x 2
x 1
3
2
4
3
unknown
in scope
2005
characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
Medium

1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
127

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
lab
Inhalation
2.07 - 4.13 mg/m3
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
128

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
lab
dermal
0.34 mg/kg bw/day
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
129

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
lubrication and grease application
Inhalation
8.26 - 15.49 mg/m3
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
130

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
lubrication and grease application
dermal
2.74 to 5.49 mg/kg bw/day
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
131

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
Spray application of agrichemicals
Inhalation
2.97 to 5.27 mg/m3
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
132

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Exposure Duration:
Use
Spray application of agrichemicals
dermal
2.21 to 5.38 mg/kg bw/day
Modelled using EasyTRA
8 hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
133

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
All
All
dermal
Input parameters are defaults as given in ECHA guidance (chapter R14
Occupational exposure estimation).
Modelled using EasyTRA
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
High
X 1
x 2
x 2
x 1
3
2
2
1
Europe
in scope
2013
Multiple data points provided with necessary metadata
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
134

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Who,. 2001. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3809476
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Analytic Method:
Use
graffiti removal
vapor
Inhalation
up to 10 mg/m3
8-hr TWA
personal
note: in paint stripper RA
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Low
Low
X 1
x 2
x 2
x 1
3
2
6
3
unknown
in scope with paint stripping?
1993-2000
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Low
2.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
135

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Who,. 2001. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3809476
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Use
microelectronic industry
vapor
Inhalation
up to 6 mg/m3
8-hr TWA
personal
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
Medium
Low
Low
X 1
x 2
x 2
x 1
3
4
6
3
unknown
Not fully specified; could be cleaning in electronics industry
1991
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Lacks worker activities
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Low

2.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
136

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Who,. 2001. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3809476
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Use
microelectronic industry
vapor
Inhalation
up to 280 mg/m3 (temperature of 80" C)
full-shift
area
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
Medium
Low
Low
X 1
x 2
x 2
x 1
3
4
6
3
unknown
Not fully specified; could be cleaning in electronics industry
1991
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Lacks worker activities
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^	Low	2.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
137

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Who,. 2001. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3809476
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Use
paint stripping
vapor
Inhalation
up to 64 mg/m3
8-hr TWA
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks worker activities
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Medium

2.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
138

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Who,. 2001. Concise International Chemical Assessment Document 35: N-Methyl-2-Pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3809476
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Use
paint stripping
vapor
Inhalation
280 mg/m3
1-hr peak
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
unknown
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Lacks worker activities
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Medium

2.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
139

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 1998. Environmental profile for N-methylpyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3827493
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Worker Activity:
Type of Sampling:
Use
photoresist remover
vapor
Inhalation
typical: 0.02 to 1.5 ppm
Industrial hygiene evaluations were performed in the die-coat application
areas, in theNMP cleaning rooms, and in rooftop stack exhausts,
area
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Low
Low
X 1
x 2
x 2
x 1
3
2
6
3
unknown
in scope
1991
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Lacks sample duration, exposure duration, frequency, and
worker activities
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
does not address variability or uncertainty.
Overall Quality Determination^
Low
2.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
140

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Occupational Exposure; Completed Exposure or Risk Assessments;
3827504
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Exposure Duration:
Exposure Frequency:
PPE:
Use
paint stripping
liquid
dermal
PBPK modelling
skin surface contact = 445 (low-end), 668 (mid), and 890 (high-end)
cm2; body weight = 74 kg
Total <230,000 workers. There were no risks to nearby worker non-users.
Assumed durations of 1-hr, 4-hrs, and 8-hrs
Acute scenarios assumed 1 day of exposure and chronic scenarios as-
sumed 5 days of exposure per week
EPA considered the impact of different combinations of PPE including:
respirator and gloves, respirator only, gloves only, and neither respirator
nor gloves.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted





sources.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized. Sam-





ple size is sufficiently representative.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Continued on next page
141

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Occupational Exposure; Completed Exposure or Risk Assessments;
3827504
EVALUATION
Domain
Metric
Rating MWF* Score Comments

Metric 7; Metadata Completeness
High X 1 1 well characterized
Overall Quality Determination^
High 1.0

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
142

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Occupational Exposure; Completed Exposure or Risk Assessments;
3827504
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Exposure Duration:
Exposure Frequency:
PPE:
Use
paint stripping
liquid
Inhalation
1.0 (low-end), 32.5 (mid), 64 (high-end) mg/m3
8-hr TWA
Miscellaneous stripping (assumed mostly indoor)
Total <230,000 workers. Professional contractors (likely to include bath-
tub refinishing): 5 workers/facility; Automotive refinishing: 6 workers/
facility; Furniture refinishing: 3 workers/facility; Art restoration and
conservation (not estimated); Aircraft paint stripping: 320 workers/
facility (for aircraft manufacturing only); Ship paint stripping: 100 work-
ers/facility. There were no risks to nearby worker non-users.
Assumed durations of 1-hr, 4-hrs, and 8-hrs
Acute scenarios assumed 1 day of exposure and chronic scenarios as-
sumed 5 days of exposure per week
EPA considered the impact of different combinations of PPE including:
respirator and gloves, respirator only, gloves only, and neither respirator
nor gloves.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted





sources.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized. Sam-
pie size is sufficiently representative.
Continued on next page
143

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3827504
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High x 1	1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
144

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Occupational Exposure; Completed Exposure or Risk Assessments;
3827504
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Exposure Duration:
Exposure Frequency:
PPE:
Use
graffiti removal
liquid
Inhalation
0.03 (low-end), 1.01 (mid), 4.52 (high-end) mg/m3
8-hr TWA
Graffiti removal (assumed mostly outdoor but may include semi-confined
spaces)
Total <230,000 workers. 8 workers/facility. There were no risks to
nearby worker non-users.
Assumed durations of 1-hr, 4-hrs, and 8-hrs
Acute scenarios assumed 1 day of exposure and chronic scenarios as-
sumed 5 days of exposure per week
EPA considered the impact of different combinations of PPE including:
respirator and gloves, respirator only, gloves only, and neither respirator
nor gloves.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted





sources.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope with paint stripping?
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized. Sam-





ple size is sufficiently representative.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Continued on next page
145

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	3827504
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	High x 1	1 well characterized
Overall Quality Determination1
High
1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
146

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Occupational Exposure; Completed Exposure or Risk Assessments;
3827504
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
paint stripping
liquid
Inhalation
0.01 to 280 mg/m3
measured - see Table Apx D-9
during stripping - see Table Apx D-9
personal
43 to 167 mins
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted
sources.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
High
X 1
x 2
x 2
x 1
1
2
2
1
US
in scope
2015
Statistical distribution of samples is fully characterized. Sam-
ple size is sufficiently representative.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination1
High

1.0

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID 3827504
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
paint stripping
liquid
Inhalation
64 mg/m3
8-hr TWA
during stripping - see Table Apx D-9
personal
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted

sources.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Statistical distribution of samples is fully characterized. Sam-
pie size is sufficiently representative.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 well characterized
Overall Quality Determination1
High
1.0

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID 3827504
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
graffiti removal
liquid
Inhalation
0.56 to 1.78 mg/m3
8-hr TWA
during graffiti removal - see Table Apx D-9
personal
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
Data and techniques are high quality; Information from trusted

sources.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope with paint stripping?
Metric 4:
Temporal Representativeness
High
X
2
2
2015
Metric 5:
Sample Size
High
X
1
1
Statistical distribution of samples is fully characterized. Sam-

ple size is sufficiently representative.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination1
High
1.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
149

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID 3827504
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
graffiti removal
vapor
Inhalation
Range: 0.01 to 24.61Geometric mean: 1.97Mean: 4.71Standard devia-
tion: 6.17
15-min short term sample
during graffiti removal - see Table Apx D-9
personal
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
Data and techniques are high quality; Information from trusted

sources.
Domain 2: Representative

ple size is sufficiently representative.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Number of Sites:
Number of Workers:
Use
Cleaning and degreasing in transportation equipment mfg industry
liquid
<10
100-499
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
151

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Number of Sites:
Number of Workers:
Use
Cleaning and degreasing in Electrical Equipment, Appliance, and Com-
ponent Manufacturing
liquid
< 10
100-499
EVALUATION
Domain Metric
Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology
High X 1 1 Trusted source - CDR data
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2011-2012
Metric 5:
Sample Size
Medium
X
1
2
Due to reporting threshold, statistical representativeness is un
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4


Continued on next
page


152

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.

Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure
or Release Data;
Hero ID
3860463

EVALUATION


Domain
Metric Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
153

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Sites:
Number of Workers:
Use
Cleaning and degreasing in Computer and Electronic Product Manufac-
turing
< 10
100-499
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
154

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Solvents (for cleaning or degreasing) in All Other Basic Organic Chem-
ical Manufacturing
Number of Sites:	< 10 (2 report); 25 - 99 (3 reports)
Number of Workers:	100-499 (1 report); 25-49 (1 report)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
155

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Number of Sites:
Number of Workers:
Use
Processing aid in Pharma
liquid
<10
10-24
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Unacceptable
x 2
8
Pharma is non-TSCA
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.1.


Continued on next
page


156

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860463
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
157

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Sites:
Number of Workers:
Use
Intermediate in Pharmaceutical and Medicine Manufacturing
10-24
500 - 999
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Unacceptable
x 2
8
Pharma is non-TSCA
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.1.


Continued on next
page


158

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860463
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
159

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Adhesive Manufacturing
Physical Form:	liquid
Number of Sites:	10-24
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
160

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Paint and Coating Manufacturing
Number of Sites:	100 - 249 (1 submission); < 10 (2 submission)
Number of Workers:	50-99 (1 submission); < 10 (1 submission)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
161

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Printing Ink Manufacturing
Number of Sites:	<10
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
162

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Plastics - incorporation into article per CDR
Number of Sites:	10-24 (1 submission); 25-99 (1 submission)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
163

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Sites:
Number of Workers:
Processing
Intermediate in Plastics Material and Resin Manufacturing
10-24
500 - 999
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
164

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Batteries
Number of Workers:	100 - 499
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X
X
X
X
1
2
2
1
1
2
2
2
US
in scope
2011-2012
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High


1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
165

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Metal finishing - Plating agents and surface treating agents
Number of Sites:	< 10
Number of Workers:	10-24
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
166

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Processing aids, not otherwise listed in Computer and Electronic Prod-
uct Manufacturing
Number of Sites:	< 10 (1 report); 25 - 99 (1 report)
Number of Workers:	100 - 499 (1 report); 500 - 999 (1 report)
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
High
Medium
XX XX
1
2
2
1
1
4
2
2
US
Unsure of scenario, could be metal fininshing or could be out
of scope
2011-2012
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
Medium


1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
167

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Commerical cleaning product formulation for electronics
Number of Workers:	1000 - 9999
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
168

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Sites:
Number of Workers:
Processing
Formulation of Pesticide,
Manufacturing
< 10
100 - 499
Fertilizer, and Other Agricultural Chemical
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
169

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3860463
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Sites:
Number of Workers:
Use
Processing aids, not otherwise listed of Pesticide, Fertilizer, and Other
Agricultural Chemical Manufacturin
10-24
100 - 499
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
170

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Processing aids, specific to petroleum production
Number of Sites:	< 10 (4 CDR reports)
Number of Workers:	500 - 999 (1 CDR report); 100 - 499 (3 reports)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
171

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Painting in Transportation Equipment Manufacturing
Number of Sites:	< 10
Number of Workers:	50 - 99
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
172

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Commercial use of Metal Products not covered elsewhere
Number of Workers:	25 - 49
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
High
Medium
XX XX
1
2
2
1
1
4
2
2
US
Unsure of scenario, could be metal fininshing or could be out
of scope
2011-2012
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
Medium


1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
173

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Commerical use of Electrical and Electronic Products
Number of Workers:	100 - 499
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
High
Medium
XX XX
1
2
2
1
1
4
2
2
US
Unsure of scenario, could be metal fininshing or could be out
of scope
2011-2012
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
Medium


1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
174

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	commerical adhesives and sealants
Number of Workers:	10-24
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High
1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
175

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):
Import
Physical Form:
liquid
Number of Sites:
>15
Number of Workers:
<10 (9 reports); 10-24 (2 reports); 25-49 (2 reports); 50-99 (1 report);

100-499 (1 report)
EVALUATION

Domain Metric
Rating MWF* Score Comments
Domain 1: Reliability

Metric 1: Methodology
High X 1 1 Trusted source - CDR data
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2011-2012
Metric 5:
Sample Size
Medium
X
1
2
Due to reporting threshold, statistical representativeness is un
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x
1
2
Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x
1
3
CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4


Continued on next
page


176

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.

Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure
or Release Data;
Hero ID
3860463

EVALUATION


Domain
Metric Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
177

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	Manufacture
Number of Sites:	>5
Number of Workers:	<10 (1 report); 10-24 (1 report); 100-499 (3 reports)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Due to reporting threshold, statistical representativeness is un-
clear.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Submissions do not include method of how number of sites and
workers were determined. CDR industry sector codes, indus-
trial processing and use codes, industrial function codes, and
commercial product codes provide good metadata; but lack of
clarifying information and narratives and occasional misreport-
ings limit clarity of data.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 CDR data do not address variability or uncertainty in submit-
ter provided data.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
178

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. PubChem: l-Methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860487
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	All
Number of Workers:	85169 workers estimated to be exposed to NMP in US at workplaces
where NMP is produced or used
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
From NIOSH
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
Low
N/A
X 1
x 2
x 2
1
4
6
N/A
US
Not fully specified; could include out of scope stages
1983
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
No metadata, but still can be applied
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium

2.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
179

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860493
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	All
Worker Activity:	all workers potentially exposed
Number of Workers:	85,169 workers
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
From NIOSH
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
Low
N/A
X 1
x 2
x 2
1
4
6
N/A
US
Not fully specified; could include out of scope stages
1983
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
No metadata, but still can be applied
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium

2.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
180

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Monitoring Data;
Hero ID
3860493
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Wood preservative
Exposure Concentration (Unit):	142 ug/m3
Type of Sampling:	area
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability





Metric 1: Methodology
Low
X
1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2: Geographic Scope
Low
X
1
3
unknown
Metric 3: Applicability
High
X
2
2
in scope
Metric 4: Temporal Representativeness
Low
X
2
6
1997
Metric 5: Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing





zone) but no other metadata.
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
Low
X
1
3
no discussion
Overall Quality Determination1
Low


2.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
181

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3969286
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Type of Measurement or Method:
Consumer Use
Coatings
liquid
dermal
Floor lacquer A = 108 cm2Writing A = 1 cm2
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
x 1
3
the model makes assumptions or uses parameter values that





lead to significant uncertainties
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
Low
x 2
6
non-occupational scenario that is similar to an occupational





scenario
Metric 4:
Temporal Representativeness
High
x 2
2
2016
Metric 5:
Sample Size
N/A

N/A
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Model approach, equations, and choice of parameter values are
transparent. However, rationale not fully described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1
well characterized
Overall Quality Determination^
Medium
2.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
182

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3969286
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Type of Measurement or Method:
Consumer Use
Cleaning
liquid
dermal
Spot removal = 230 cm2Paint remover = 430 cm2Sealant /foam remover
A = 5 cm2
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
the model makes assumptions or uses parameter values that
lead to significant uncertainties
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Low
High
N/A
X 1
x 2
x 2
2
6
2
N/A
Australia
non-occupational scenario that is similar to an occupational
scenario
2016
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Model approach, equations, and choice of parameter values are
transparent. However, rationale not fully described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
Medium
2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
183

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3969286
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Consumer Use
Ink
vapor
Inhalation
Assumed negligible due to small volume of use
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
x 1
3
the model makes assumptions or uses parameter values that





lead to significant uncertainties
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
Low
x 2
6
non-occupational scenario that is similar to an occupational





scenario
Metric 4:
Temporal Representativeness
High
x 2
2
2016
Metric 5:
Sample Size
N/A

N/A
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Model approach, equations, and choice of parameter values are
transparent. However, rationale not fully described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1
well characterized
Overall Quality Determination^
Medium
2.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
184

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3969286
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Consumer Use
Coating and cleaning
vapor
Inhalation
mean concentration ranged 54.3 to 217 mg/m3 for products containing
50 and 25 percent of NMP; 10.4 to 113 mg/m3 for 5 percent NMP; and
0.623 to 12.9 for mg/m3 for 0.3 percent NMP
Modelled based on Csaturation and parameters in Table 5 (ventilation,
time)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
the model makes assumptions or uses parameter values that
lead to significant uncertainties
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Low
High
N/A
X 1
x 2
x 2
2
6
2
N/A
Australia
non-occupational scenario that is similar to an occupational
scenario
2016
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Model approach, equations, and choice of parameter values are
transparent. However, rationale not fully described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
Medium

2.0

Continued on next page
185

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3969286
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
186

Domain
Metric
Rating
MWF*
Score

Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Information
is from trusted sources (NIOSH HHE)
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US

Metric 3:
Applicability
High
x 2
2
Agriculutral
use is in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2014

Metric 5:
Sample Size
High
x 1
1
Sample size
is sufficiently representative. Results are from in-
terviewing of 20 employees.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1 1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1 1
The report addresses variability and uncertainty in the results.

Continued on next page
187

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Niosh,. 2014. Health hazard evaluation report no. HHE-2011-0099-3211, evaluation of employee exposures during sea lamprey
pesticide application.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3974909
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
188

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter Data
Life Cycle Stage: All
Life Cycle Description (Subcategory of Use): Source was listed for exposure data, but only contained exposure limits.
No data extracted
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
OSHA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Unacceptable
High
N/A
X 1
x 2
x 2
1
8
2
N/A
US
No information relevant to assessed conditions of use
2010
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Unacceptable

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Osha,. 2017. Sampling and analytical methods: N-methyl-2-pyrrolidinone.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3978312
EXTRACTION

Parameter
Data
Life Cycle Stage: All
Life Cycle Description (Subcategory of Use): Source was listed for exposure data, but only contained exposure limits.
No data extracted
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
OSHA
Domain 2: Representative

Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
Unacceptable
X
2
8
No information relevant to assessed conditions of use
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 1.9.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
190

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978357
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Worker Activity:
Number of Workers:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Formulation
polymeric adhesive for leather coating application
liquid, 5 percent
dermal
Transferring and adding primal Binder U-51 and other components into
the mixing vessel.
2-3 /site
4-6 hours/day
100 days/year
Exhaust ventilation systems are installed in the mixing room.
Safety glasses, impervious gloves. Overalls and safety boots
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
x 1
Information is from trusted sources
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium	X 1	2	Australia
High	X 2	2	Adhesive formulation is in scope
Medium	x 2	4	2001
Low	X 1	3	Distribution of samples is qualitative
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x
1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x
1
2
limited discussion
Overall Quality Determination^
Medium

1.7


Continued on next
page


191

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978357
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
192

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Worker Activity:
Number of Workers:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Use
spray application of polymeric adhesive for leather coating application
liquid, 5 percent
dermal, inhalation
Transferring basecoat and operating spray machines. Placing substrates
on conveyor line.
2-3 /site
6-8 hours/day
100 days/year
Enclosed rotary spray unit. An exhaust ventilation system is present
above the spray machines and any overspray is filtered and caught in a
water curtain filtering system.
Safety glasses, impervious gloves. Overalls and safety boots
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information is from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
Adhesive use is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2001
Metric 5:
Sample Size
Low
x 1
3
Distribution of samples is qualitative
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-





sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
limited discussion
Continued on next page
193

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Occupational Exposure; Reports for Data or Information Other than Exposure
3978357
or Release Data;
EVALUATION


Domain
Metric Rating MWF* Score
Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
194

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Worker Activity:
Number of Workers:
Processing
Distribution polymeric adhesive for leather coating application
liquid, 5 percent
dermal
Load/unload drums from trucks. No exposure anticipated except in the
event of an accident.
5 Waterside, workers, 5-10 transport and warehouse workers
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information is from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
Low
X 1
x 2
x 2
x 1
2
2
4
3
Australia
Distribution is in scope
2001
Distribution of samples is qualitative
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
195

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Basf,. 1990. Technical information: N-methylpyrrolidone handling and storage.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982070
EXTRACTION

Parameter
Data
Life Cycle Stage: All
Life Cycle Description (Subcategory of Use): recommended PPE
PPE: Chemical splash goggles should be worn. Gloves of butyl rubber and
FEP Teflon provide the best resistance to NMP. Gloves should be rinsed
following use and discarded. Butyl rubber aprons may be used for splash
protection, however, the PVC coatings' found on much protective cloth-
ing rapidly dissolve in NMP.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
Low
N/A
X 1
x 2
x 2
1
4
6
N/A
US
Information is not related to a life cycle stage, but is broadly
applicable
1990
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^ Low 2.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
196

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3982074
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Worker Activity:
Type of Sampling:
Use
immersion degreasing
vapor
Inhalation
average = 0.31 ppm
collection tube was located 5.0 feet away from the front lip of the de-
greaser top (exhaust hood was located at back lip of degreaser top) and
3.0 feet off of the floor
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
The data, data sources, and/or techniques used in the assess-





ment or report are not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1993
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
provides results, but the underlying methods, data sources,
and assumptions are not fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination1
Low

2.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
197

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3982074
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Worker Activity:
Type of Sampling:
Use
immersion degreasing
vapor
Inhalation
average =1.84 ppm
Collection tube was taped into place on the workers shirt
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
The data, data sources, and/or techniques used in the assess-





ment or report are not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1993
Metric 5:
Sample Size
Low
x 1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
provides results, but the underlying methods, data sources,
and assumptions are not fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Low

2.3


* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
198

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Oehha,. 2007. Occupational health hazard risk assessment project for California: Identification of chemicals of concern,
possible risk assessment methods, and examples of health protective occupational air concentrations.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3982225
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Exposure Duration:
Exposure Frequency:
All
All
vapor
Inhalation
0.4 to 5 ppm
modelled using interspecies uncertainty factors
Workers were assumed to breathe 10 m3 out of a daily breathing rate of
20 m3/day, and be exposed at the PEL for 5 days per week.
8 hrs
5 days/wk
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Seems sound, but utilizes animal studies to derive human val-
ues
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
can be appropriately applied
2007
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Model approach, equations, and choice of parameter values are
transparent and clear and can be evaluated. Rationale for se-
lection of approach, equations, and parameter values is pro-
vided.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
The model characterizes variability and uncertainty in the re-
sults.
Continued on next page
199

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Oehha,. 2007. Occupational health hazard risk assessment project for California: Identification of chemicals of concern,
possible risk assessment methods, and examples of health protective occupational air concentrations.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3982225
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

High 1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
200

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Hesis,. 2014. N-methylpyrrolidone (nmp):
Health haazard advisory: Fact sheet.
Type of Data Source
Occupational Exposure; Reports for Data
or Information Other than Exposure or Release Data;
Hero ID
3982238

EXTRACTION


Parameter

Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Type of Measurement or Method:
PPE:
Use
all
This document lists health effects and suggested PPE.
Half-face respirator with organic vapor cartridges. In spraying opera-
tions, this should be combined with a mist pre-filter. Wear chemical
protective utility gloves such as butyl rubber or Silvershield" (laminated
polyethylene/EVOH). NMP will go right through less durable gloves
such as those made of natural rubber, nitrile, or polyethylene. Replace
gloves often. Use chemical protective clothing such as aprons, sleeves,
boots, and head and face protection if NMP can contact your skin at
areas other than your hands.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
CalOSHA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
PPE suggestions applicable to in-scope uses
2014
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
High

1.3

Continued on next page
201

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Hesis,. 2014. N-methylpyrrolidone (nmp):
Occupational Exposure; Reports for Data
3982238
Health haazard advisory: Fact sheet,
or Information Other than Exposure or
Release Data;
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
202

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3982353
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Sampling:
Analytic Method:
Use
graffiti removal
vapor
Inhalation
up to 10 mg/m3
personal
note: in paint stripper RA
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Low
Low
X 1
x 2
x 2
x 1
3
2
6
3
unknown
in scope with paint stripping?
1993-2000
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Low
2.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
203

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3982353
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Sampling:
Use
microelectronic industry
vapor
Inhalation
up to 6 mg/m3 (reg temp); up to 280 mg/m3 (temperature of 80"C)
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
Medium
Low
Low
X 1
x 2
x 2
x 1
3
4
6
3
unknown
Not fully specified; could be cleaning in electronics industry
1991
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Low
2.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
204

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 3982353
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Sampling:
Analytic Method:
Use
paint stripping
vapor
Inhalation
up to 64 mg/m3; peak 280 mg/m3
personal
note: in paint stripper RA
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
Medium
Low
X 1
x 2
x 2
x 1
3
2
4
3
unknown
in scope
2000
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but no other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
2.2
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
205

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3982353
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
All
All
vapor
dermal
30 percent of the total inhalation dose
experimental study in human volunteers
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2: Geographic Scope
Low
X
1
3
unknown
Metric 3: Applicability
Medium
X
2
4
Not fully specified; could be applied to in scope
Metric 4: Temporal Representativeness
Medium
X
2
4
2007
Metric 5: Sample Size
Low
X
1
3
characterized by no statistics.
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
Low
X
1
3
No metadata, but still can be applied
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
Medium
X
1
2
limited discussion
Overall Quality Determination^
Low


2.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
206

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3982353
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
All
All
dermal
15 minutes exposure to 15 percent aqueous NMPis equivalent to inhala-
tion of 10 mg/m3 NMP with respect to absorption
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
Medium
Medium
Low
X 1
x 2
x 2
x 1
3
4
4
3
unknown
Not fully specified; could be applied to in scope
2002
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
No metadata, but still can be applied
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Low

2.4

* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
207

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Ec,. 2007. Recommendation from the scientific committee on occupational exposure limits for n-methyl-2-pyrrolidone.
Type of Data Source
Occupational Exposure; Monitoring Data;
Hero ID
3982353
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	All
Route of Exposure:	dermal
Exposure Concentration (Unit):	permeability rate through human skin of 171 + 59 g/m3 has been derived
for NMP
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
Medium
Low
Low
X 1
x 2
x 2
x 1
3
4
6
3
unknown
Not fully specified; could be applied to in scope
1995
characterized by no statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
No metadata, but still can be applied
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Low

2.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
208

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2013. OPPT N-Methylpyrrolidone (NMP) draft risk assessment final comments of nine member peer review
panel December 31, 2013.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986611
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Type of Measurement or Method:
Use
paint stripping
This source is a review of EPA's Draft Paint Stripping RA. It lists mod-
elling considerations.
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Medium X 1 2 The assessment or report uses high quality data and/or tech-
niques that are not from trusted sources; however, Associated
information does not indicate flaws or quality issues.
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
2013
Metric 5: Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
Medium
X
1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
Medium
X
1
2
limited discussion of the variability and uncertainty in the re-

sults
Overall Quality Determination^
High

1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Thomas, T. 2017. Comment submitted by Todd Thomas, ELANTAS PDG, Inc. (EPDG).
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
3986789
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Number of Workers:
Engineering Control & percent Exposure Reduction:
Processing /Use
Polymers and Electronics (wires)
5 to 10
NMP is used in the following process conditions: Enclosed process vessels
with emissions sent to an RTO; includes manufacturing and cleaning op-
erations; Small enclosed process vessel (<30 gallons); emissions are fugi-
tive; Filling operations into drums, IBC's and tank wagons; emissions
are fugitive; Bulk and container storage operations; Regulated metal
parts washers; emissions are fugitive
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
210

N/A
No Comment.
Overall Quality Determination^
High

1.1

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,

NMP Producers Group, Inc.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986796
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): electronics - Soldermask Stripping
Engineering Control & percent Exposure Reduction: open topped tankequipped with ventilation
PPE: Worker exposure is controlledvia ventilation and use of appropriate PPE.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^ High 1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
212

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,

NMP Producers Group, Inc.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986796
EXTRACTION

Parameter
Data
Life Cycle Stage: Processing
Life Cycle Description (Subcategory of Use): Chemical processing, excluding formulation (polymer manufacturing)
Engineering Control & percent Exposure Reduction: closedreaction system; local ventilation
PPE: personnel areequipped with PPE
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,

NMP Producers Group, Inc.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986796
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Fertilizer application
Engineering Control & percent Exposure Reduction:	closed system tank mixer in acontinuous process
PPE:	PPE, respirators
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^	High	1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
214

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Isaacs, D. 2017. Comment submitted by David Isaacs, Semiconductor Industry Association (SIA).
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986801
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Engineering Control & percent Exposure Reduction:
PPE:
Use
Electronics - semiconductor manufacturing
The wafer fabrication activities listed in this table would normally be
conducted within robotically operated enclosed tools, where engineering
controls (chamber containment) provide exposure control during normal
operations. List of specific controls on page 10.
Unspecified PPE
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
Trade association poll of manufacturers. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
215

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
216

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Worker Activity:
Type of Sampling:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
0.005 ppm (mean) 0.2 ppm (max)
21.0
1.0
Organic polymer prep and solvent recovery
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1989
Metric 5:
Sample Size
Medium
x 1
2
Characterized by a range
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.1
Continued on next page
217

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
218

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Worker Activity:
Type of Sampling:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
0.2 ppm, 1 ppm
2.0
1.0
Manufacture of composite prepreg
personal
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
219

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
220

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Worker Activity:
Type of Sampling:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
6 ppm, 1 ppm
2.0
1.0
Resin heating mill hood
area
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
221

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
222

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Use
Paints and Coatings application
Vapor
Inhalation
0.13 ppm (mean)0.2 (max)
3.0
Number of Sites:

1.0



Worker Activity:

Equipment clean up
in
paint shop
Type of Sampling:

personal



Sampling Location:

paint shop



EVALUATION





Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Use in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1989
Metric 5:
Sample Size
Medium
x 1
2
Characterized by a range
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Monitoring data lacks sample durations and/or measurement





method
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Continued on next page
223

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	2.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
224

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Worker Activity:
Type of Sampling:
Exposure Frequency:
PPE:
Use
Paints and Coatings application
Vapor
Inhalation
2.0 ppm (mean)3.0 ppm (max)
2.0
1.0
Solvent for spray application of roll coating
personal
25 min
Respiratory and skin protection worn
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Use in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1989
Metric 5:
Sample Size
Medium
x 1
2
Characterized by a range
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Continued on next page
225

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

Medium 2.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
226

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Curing composite article at 800 F
personal
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
227

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
228

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Curing composite article at 800 F
area
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
229

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
230

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Devolatilizing composite article in laboratory hood
personal
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Medium
X
1
2
Monitoring data lacks sample durations and/or measurement






method
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
231

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Devolatilizing composite article in ventilated press
personal
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
232

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
233

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Devolatilizing composite article in ventilated press
area
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
234

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
235

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Impregnating fibers with resin in laboratory hood
personal
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Medium
X
1
2
Monitoring data lacks sample durations and/or measurement






method
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
236

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
2.0
Cut patterns from prepreg and devolatilized for 2 hours
personal
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
237

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
238

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Cut patterns from prepreg and devolatilized for 2 hours
area
Respiratory and skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
239

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
240

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
<0.1 ppm
1.0
Operator cut patterns from prepreg
personal
skin protection worn
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Processing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
High
X
1
1
Discrete data point provided
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Medium
X
1
2
Monitoring data lacks sample durations and/or measurement






method
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
No discussion on uncertainty and variability
Overall Quality Determination^	Medium	2.0
Continued on next page
241

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
242

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
Exposure Frequency:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
5.2 ppm
1.0
Clean up of 310 F heater plates
personal
9 min
Respiratory and skin protection worn
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
High
X 1
x 2
x 2
x 1
1
2
6
1
US
Processing in scope
1989
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Continued on next page
243

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
244

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
Exposure Frequency:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
3.7 ppm, 10 ppm
2.0
Clean up of 310 F heater plates
personal
13 min
Respiratory and skin protection worn
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
High
X 1
x 2
x 2
x 1
1
2
6
1
US
Processing in scope
1989
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Continued on next page
245

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
246

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Worker Activity:
Type of Sampling:
Exposure Frequency:
PPE:
Processing
Processing Non-Incorporative (polymer manufacturing)
Vapor
Inhalation
12 ppm
1.0
Clean up of 310 F heater plates
personal
17 min
Respiratory and skin protection worn
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
High
X 1
x 2
x 2
x 1
1
2
6
1
US
Processing in scope
1989
Discrete data point provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Monitoring data lacks sample durations and/or measurement
method
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Continued on next page
247

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4214100
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	Medium	2.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
248

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Manufacturing
Manufacturing
Vapor
Inhalation
5	mg/day,avg breathing rate of 1.25 m3/hr
3.0
CEB drumming model
sampling and packaging
6	to 10 per site
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

Continued on next page
249

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EVALUATION
Domain
Metric
Rating
MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
250

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Manufacturing
Manufacturing
liquid
Dermal contact
1300 - 3900 mg/day
3.0
CEB two hand immersion model
sampling and packaging
6 to 10 per site
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

Continued on next page
251

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EVALUATION
Domain
Metric
Rating
MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
252

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 4214135
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Processing
Processing Non-Incorporative (lube oil extraction)
vapor
Inhalation
>0.1 mg/day
CEB sampling model
Lube oil extraction
5999 - 17000
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 4214135
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Processing
Processing Non-Incorporative (lube oil extraction)
liquid
Dermal contact
1300 - 3900 mg/day
CEB two hand immersion model
Lube oil extraction
6000 - 17000
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Use
Paint and coating removers
Vapor
Inhalation
up to 16 mg/day
Manipulating current methylene chloride data by vapor pressures
Stripper applied to surface by spraying or brushing or dipping. Time
given to penetrate. Stripper removed, wiped or scraped.
2,500-10,700
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

Continued on next page
255

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EVALUATION
Domain
Metric
Rating
MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
256

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Number of Workers:
PPE:
Use
Paint and coating removers
liquid
Dermal contact
400-975 mg/day
CEB two hand immersion model
Stripper applied to surface by spraying or brushing or dipping. Time
given to penetrate. Stripper removed, wiped or scraped.
2,500-10,701
Respiratory and skin protection worn
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
In scope
1989
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion on uncertainty and variability
Overall Quality Determination^
Medium

1.8

Continued on next page
257

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Us, E. P. A.. 1989. SUMMARY ENGINEERING REPORT TEST RULES EXPOSURE ANALYSIS N-
METHYLPYRROLIDONE WITH COVER LETTER DATED 110189.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214135
EVALUATION
Domain
Metric
Rating
MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
258

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Manufacturing /Processing
Chemical industry and mineral oil processing - likely formulation of so-
lutions
vapor
Inhalation
0.175 (50th; below LOQ), 13.41 (90th), 16.93 (95th) mg/m3
11.0
6.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Potentially contains some scenarios that are out of scope. Con-





tains some that are in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

259

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
260

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Plastics and plastic foam processinc/mfg
vapor
Inhalation
0.3 (50th; below LOQ), 3 (90th), 3.5 (95th) mg/m3
40.0
28.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Polymer processing is in scope, but due to unknown opera-





tions considered in this industry, this may include out of scope





scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

261

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
262

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
stones, earth, ceramics, glass industry
vapor
Inhalation
0.2 (50th; below LOQ), 0.68 (90th), 0.74 (95th) mg/m3
12.0
8.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION



Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability



Metric 1:
Methodology
High
X 1 1 Sampling or analytical methodology is an approved OSHA or



NIOSH method
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Medium	x 1
Unacceptable x 2
Metric 4: Temporal Representativeness High	x 2
Metric 5: Sample Size	Medium	x 1
2 Germany
8	Not in scope, doesn"t seem applicable to those scenarios in
scope
2 2010
2	Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page


263

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
Overall Quality Determination^	Unacceptable	4 Metric Mean Score: 2.3.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
264

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Mfg and processing of metals - processing of liquid coating materials
vapor
Inhalation
0.2 (50th; below LOQ), 13.41 (90th), 24.65 (95th) mg/m3
43.0
27.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
Formulation of coating materials for metals
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty


Continued on next
page

265

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
IFA. 2010. MEGA evaluations for the preparation of REACH exposure
scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source
Occupational Exposure; Monitoring Data;

Hero ID
4271620

EVALUATION


Domain
Metric Rating MWF* Score
Comments
Overall Quality Determination^	Medium	1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
266

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Steel construction, mfg of machinery and vehicles
vapor
Inhalation
below LOD (50th), 5.02 (90th), 7.36 (95th) mg/m3
16.0
9.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

267

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
268

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Electrical, fine mechanics, optics
vapor
Inhalation
0.3 (50th; below LOQ), 3.54 (90th), 6.2 (95th) mg/m3
44.0
33.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

269

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
270

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
woodworking, paper, printing
vapor
Inhalation
below LOD (50th), 1 (90th), 1.7 (95th) mg/m3
40.0
23.0
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
271

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
272

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Use
Painting cars
vapor
Inhalation
0.2 (50th; below LOQ), 0.5 (90th), 2.5 (95th) mg/m3
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
Painting is in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low x
1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x
1
3
The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium

1.7


Continued on next
page


273

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
IFA. 2010. MEGA evaluations for the preparation of REACH exposure
scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source
Occupational Exposure; Monitoring Data;

Hero ID
4271620

EVALUATION


Domain
Metric Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
274

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Manufacturing /Processing
Chemical industry and mineral oil processing - likely formulation of so-
lutions
vapor
Inhalation
0.45 (50th; below LOQ), 6 (90th), 9.5 (95th) mg/m3
30.0
11.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Potentially contains some scenarios that are out of scope. Con-





tains some that are in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

275

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
276

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Plastics and plastic foam processinc/mfg
vapor
Inhalation
0.35 (50th; below LOQ), 2.93 (90th), 4.985 (95th) mg/m3
61.0
35.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Polymer processing is in scope, but due to unknown opera-





tions considered in this industry, this may include out of scope





scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

277

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
278

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Mfg and processing of metals - processing of liquid coating materials
vapor
Inhalation
0.5 (50th), 2.72 (90th), 3 (95th) mg/m3
44.0
20.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
Formulation of coating materials for metals
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty


Continued on next
page

279

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
IFA. 2010. MEGA evaluations for the preparation of REACH exposure
scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source
Occupational Exposure; Monitoring Data;

Hero ID
4271620

EVALUATION


Domain
Metric Rating MWF* Score
Comments
Overall Quality Determination^	Medium	1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
280

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Steel construction, mfg of machinery and vehicles
vapor
Inhalation
0.3 (50th; below LOQ), 1.75 (90th), 2.725 (95th) mg/m3
15.0
12.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

281

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
282

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
Electrical, fine mechanics, optics
vapor
Inhalation
below LOD (50th), 9.6 (90th), 11.9 (95th) mg/m3
21.0
15.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

283

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
284

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Processing
woodworking, paper, printing
vapor
Inhalation
0.2 (50th; below LOQ), 3.2 (90th), 12.8 (95th) mg/m3
39.0
19.0
TWA?
personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
285

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
286

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Use
Building industry
vapor
Inhalation
I.5	(50th), 6.6 (90th), 7.9 (95th) mg/m3
II.0
7.0
TWA?
personal
sample time >=lhr; exposure duration > =
6hr
EVALUATION







Domain
Metric
Rating
MWF*
Score
Comments

Domain 1: Reliability







Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an
approved OSHA or






NIOSH method

Domain 2: Representative







Metric 2:
Geographic Scope
Medium
X
1
2
Germany

Metric 3:
Applicability
Medium
X
2
4
due to unknown operations considered in
this industry, this






may include out of scope scenarios

Metric 4:
Temporal Representativeness
High
X
2
2
2010

Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by
a range with uncer-






tain statistics.

Domain 3: Accessibility/Clarity






Metric 6:
Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g.,
personal breathing






zone) but lack other metadata.

Domain 4: Variability and Uncertainty






Metric 7:
Metadata Completeness
Low
X
1
3
The monitoring study does not address variability or uncer-






tainty

Continued on next page
287

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
288

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Manufacturing /Processing
Chemical industry and mineral oil processing - likely formulation of so-
lutions
vapor
Inhalation
0.45 (50th; below LOQ), 12.5 (90th), 16.8 (95th) mg/m3
30
11
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Potentially contains some scenarios that are out of scope. Con-





tains some that are in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
289

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
290

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Plastics and plastic foam processinc/mfg
vapor
Inhalation
0.5 (50th), 3.45 (90th), 4.775 (95th) mg/m3
65
31
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
Medium
X
2
4
Polymer processing is in scope, but due to unknown opera-
tions considered in this industry, this may include out of scope
scenarios
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
291

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
292

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
stones, earth, ceramics, glass industry
vapor
Inhalation
0.3 (50th; below LOQ), 0.78 (90th), 0.92 (95th) mg/m3
12
9
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION



Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability



Metric 1:
Methodology
High
X 1 1 Sampling or analytical methodology is an approved OSHA or



NIOSH method
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Medium	x 1
Unacceptable x 2
Metric 4: Temporal Representativeness High	x 2
Metric 5: Sample Size	Medium	x 1
2 Germany
8	Not in scope, doesn"t seem applicable to those scenarios in
scope
2 2010
2	Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page


293

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
Overall Quality Determination^	Unacceptable	4 Metric Mean Score: 2.3.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
294

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Mfg and processing of metals - processing of liquid coating materials
vapor
Inhalation
0.55 (50th; below LOQ), 4 (90th), 6.5 (95th) mg/m3
55
26
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
Formulation of coating materials for metals
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
295

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
296

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Steel construction, mfg of machinery and vehicles
vapor
Inhalation
0.55 (50th; below LOQ), 5.8 (90th), 7.45 (95th) mg/m3
15
10
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
297

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
298

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Electrical, fine mechanics, optics
vapor
Inhalation
0.2 (50th; below LOQ), 3 (90th), 3.9 (95th) mg/m3
40
25
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
299

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
300

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
woodworking, paper, printing
vapor
Inhalation
below LOD (50th), 1 (90th), 3.855 (95th) mg/m3
33
23
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
301

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
302

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
woodworking, paper, printing
vapor
Inhalation
Inhalation
0.2 (50th; below LOQ), 2.35 (90th), 3 (95th) mg/m3
45
22
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
303

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
304

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Plastics and plastic foam processinc/mfg
vapor
Inhalation
0.2 (50th; below LOQ), 1.92 (90th), 2.9 (95th) mg/m3
22
14
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
Medium
X
2
4
Polymer processing is in scope, but due to unknown opera-
tions considered in this industry, this may include out of scope
scenarios
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
305

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
306

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Mfg and processing of metals - processing of liquid coating materials
vapor
Inhalation
0.2 (50th; below LOQ), 13.45 (90th), 86.9 (95th) mg/m3
19
12
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
Formulation of coating materials for metals
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
307

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
308

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Steel construction, mfg of machinery and vehicles
vapor
Inhalation
below LOD
15
10
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Likely related to degreasing, which is in scope, but due to un-





known operations considered in this industry, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
309

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
310

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
woodworking, paper, printing
vapor
Inhalation
below LOD (50th), 1.7 (90th), 1.74 (95th) mg/m3
33
23
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
311

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
312

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
woodworking, paper, printing
vapor
Inhalation
0.045 (50th; below LOQ), 28 (90th), 34 (95th) mg/m3
45
22
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of





scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
313

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
314

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
All
All
vapor
Inhalation
below LOD (50th), 0.64 (90th), 1.155 (95th) mg/m3
13
7
TWA?
storing, conveying
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
due to unknown industries for this activity, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
315

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
316

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Processing and treatment of wood
vapor
Inhalation
below LOD (50th), 49.8 (90th), 149.8 (95th) mg/m3
24
9
TWA?
processing, sanding, removal
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Application of finishing to wood is in scope, but sanding and





removal may not be
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

317

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
318

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Processing of plastic and plastic foam
vapor
Inhalation
0.2 (50th; below LOQ), 3 (90th), 5.35 (95th) mg/m3
82
55
TWA?
surface coating and painting
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1 3
The monitoring study does not address variability or uncer-
tainty
Continued on next page
319

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
320

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Metals, fine mechanics, optics
vapor
Inhalation
0.7 (50th), 15 (90th), 90 (95th) mg/m3
30
15
TWA?
cleaning
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1 3
The monitoring study does not address variability or uncer-
tainty
Continued on next page
321

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
322

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Mfg of shoes; Processing of plastic and plastic foam
vapor
Inhalation
0.2 (50th; below LOQ), 3.76 (90th), 5.52 (95th) mg/m3
18
10
TWA?
gluing
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
Medium
X
2
4
Adhesive use is in scope, but this may also include out of scope






scenarios
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-






tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
323

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
324

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Use
Foundries
vapor
Inhalation
below LOD (50th), 15.8 (90th), 21.1 (95th) mg/m3
11
5
TWA?
area
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope	Medium	x 1	2
Applicability	Unacceptable	x 2	8
Temporal Representativeness High	x 2	2
Sample Size	Medium	x 1	2
Germany
the function in this industry is unknown
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 The monitoring study does not address variability or uncer-
tainty
Continued on next page
325

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
Overall Quality Determination^	Unacceptable	4 Metric Mean Score: 2.3.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
326

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Processing
Mfg of coatings, adhesives
vapor
Inhalation
0.35 (50th; below LOQ), 3.45 (90th), 5.875 (95th) mg/m3
21
11
TWA?
mixing, pressing (compacting)
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments

Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an
NIOSH method
approved OSHA or
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by
tain statistics.
a range with uncer-
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g.
zone) but lack other metadata.
personal breathing
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
The monitoring study does not address variability or uncer-
tainty
Continued on next page
327

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
328

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
processing plastics and plastic
vapor
Inhalation
below LOD (50th), 0.38 (90th; below LOQ), 0.49 (95th) mg/m3
11
6
TWA?
foaming
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
Potenitally in scope; function of NMP for plastics not well





known
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5: Sample Size
Medium x 1
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

329

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
330

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Processing and treatment of wood
vapor
Inhalation
0.5 (50th), 8.4 (90th), 13.9 (95th) mg/m3
13
8
TWA?
sanding
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Application of finishing to wood is in scope, but sanding and





removal may not be
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty

Continued on next
page

331

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
332

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Processing of plastic and plastic foam
vapor
Inhalation
0.65 (50th), 3 (90th), 4.865 (95th) mg/m3
69
39
TWA?
surface coating and painting
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1 3
The monitoring study does not address variability or uncer-
tainty
Continued on next page
333

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
334

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Metals, fine mechanics, optics
vapor
Inhalation
2 (50th), 12.35 (90th), 18.875 (95th) mg/m3
23
17
TWA?
cleaning
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1 3
The monitoring study does not address variability or uncer-
tainty
Continued on next page
335

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
336

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
Mfg of shoes; Processing of plastic and plastic foam
vapor
Inhalation
0.3 (50th; below LOQ), 1.94 (90th), 2.095 (95th) mg/m3
21
14
TWA?
gluing
Personal
sample time >=lhr; exposure duration >= 6hr
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
Medium
X
2
4
Adhesive use is in scope, but this may also include out of scope






scenarios
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-






tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
337

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
338

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Processing and treatment of wood
vapor
Inhalation
below LOD (50th), 5.72 (90th), 7.8 (95th) mg/m3
12
5
TWA?
sanding
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments

Domain 1: Reliability






Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an
NIOSH method
approved OSHA or
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X 1
2
Germany

Metric 3:
Applicability
Medium
x 2
4
Application of finishing to wood is in scope, but sanding and
removal may not be
Metric 4:
Temporal Representativeness
High
x 2
2
2010

Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by
tain statistics.
a range with uncer-
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g.,
zone) but lack other metadata.
personal breathing
Domain 4: Variability and Uncertainty
Continued on next page
339

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
340

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Processing of plastic and plastic foam
vapor
Inhalation
below LOD (50th), 3.24 (90th), 4.055 (95th) mg/m3
17
11
TWA?
surface coating and painting
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
341

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
342

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Metals, fine mechanics, optics
vapor
Inhalation
0.4 (50th; below LOQ), 79.6 (90th), 102.1 (95th) mg/m3
11
6
TWA?
cleaning
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
343

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
344

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Mfg of shoes; Processing of plastic and plastic foam
vapor
Inhalation
below LOD (50th), 0.2 (90th; below LOQ), 0.245 (95th; below LOQ)
mg/m3
11
7
TWA?
gluing
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken WITHOUT LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Adhesive use is in scope, but this may also include out of scope





scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low	X 1	3 Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Continued on next page
345

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION
Domain
Metric
Rating
MWF* Score Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium
1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
346

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
All
All
vapor
Inhalation
0.2 (50th; below LOQ), 0.7 (90th), 1.35 (95th) mg/m3
10
4
TWA?
storing, conveying
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
due to unknown industries for this activity, this may include





out of scope scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-





tain statistics.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing





zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
347

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
348

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Processing
Mfg of coatings, adhesives
vapor
Inhalation
below LOD (50th), 3.45 (90th), 5.875 (95th) mg/m3
21
9
TWA?
mixing, pressing (compacting)
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
349

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
350

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
processing plastics and plastic
vapor
Inhalation
below LOD (50th), 0.88 (90th), 1.84 (95th) mg/m3
13
7
TWA?
foaming
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments

Domain 1: Reliability






Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an
NIOSH method
approved OSHA or
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X 1
2
Germany

Metric 3:
Applicability
High
x 2
2
Potenitally in scope; function of NMP for plastics not well
known
Metric 4:
Temporal Representativeness
High
x 2
2
2010

Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by
tain statistics.
a range with uncer-
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g.,
zone) but lack other metadata.
personal breathing
Domain 4: Variability and Uncertainty
Continued on next page
351

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
352

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Processing and treatment of wood
vapor
Inhalation
below LOD (50th), 1 (90th), 1 (95th) mg/m3
14
7
TWA?
sanding
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments

Domain 1: Reliability






Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an
NIOSH method
approved OSHA or
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X 1
2
Germany

Metric 3:
Applicability
Medium
x 2
4
Application of finishing to wood is in scope, but sanding and
removal may not be
Metric 4:
Temporal Representativeness
High
x 2
2
2010

Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by
tain statistics.
a range with uncer-
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g.,
zone) but lack other metadata.
personal breathing
Domain 4: Variability and Uncertainty
Continued on next page
353

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
354

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Processing of plastic and plastic foam
vapor
Inhalation
0.3 (50th; below LOQ), 3.76 (90th), 5.46 (95th) mg/m3
108
68
TWA?
surface coating and painting
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
355

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
356

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Metals, fine mechanics, optics
vapor
Inhalation
0.9 (50th), 10.85 (90th), 13.125 (95th) mg/m3
35
19
TWA?
cleaning
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
357

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
358

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Mfg of shoes; Processing of plastic and plastic foam
vapor
Inhalation
0.45 (50th; below LOQ), 4.28 (90th), 6.96 (95th) mg/m3
24
13
TWA?
gluing
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Adhesive use is in scope, but this may also include out of scope





scenarios
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
359

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
360

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Type of Sampling:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Foundries
vapor
Inhalation
below LOD (50th), 0.6 (90th), 0.75 (95th) mg/m3
TWA?
unknown
sample time >=lhr; exposure duration >= 6hr
samples taken in the presence of LEV
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or






NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
Medium
X
1
2
Germany
Metric 3:
Applicability
Unacceptable
X
2
8
Not in scope, doesn"t seem applicable to those scenarios in






scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Medium
X
1
2
Distribution of samples is characterized by a range with uncer-






tain statistics.
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
Monitoring data include sample type (e.g., personal breathing






zone) but lack other metadata.
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
The monitoring study does not address variability or uncer-






tainty
Continued on next page
361

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
Overall Quality Determination^	Unacceptable	4 Metric Mean Score: 2.3.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
362

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Painting - manufacture and processing of metals
vapor
Inhalation
0.7 (50th),3.86 (90th), 5.415 (95th) mg/m3
37
19
TWA
Industry listed as "manufacture and processing of metals." Work group
area listed as "surface coating, painting." Unknown application type.
Unknown area of sampling. No additional details are provided,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
363

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
364

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Cleaning - manufacture and processing of metals
vapor
Inhalation
1.5 (50th),57 (90th), 96.4 (95th) mg/m3
14
7
TWA
Industry listed as "manufacture and processing of metals." Work group
area listed as "cleaning." Unknown application type. Unknown area of
sampling. No additional details are provided,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
365

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
366

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or

OSHA, but seems acceptable.
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Medium
x 2
4
Printing is in scope. Woodworking and paper may be out of

scope.
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-

tain statistics.
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing

zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
367

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
368

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Steel construction, manufacture of machinery and vehicles
vapor
Inhalation
0.7 (50th), 5.56 (90th), 7.36 (95th) mg/m3
16
9
TWA
Listed as "Steel construction, manufacture of machinery and vehicles."
Work goup listed as :surface coating, painting."
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
369

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
370

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electrical engineering, fine mechanics, optics
vapor
Inhalation
below LOD (50th), 1.22 (90th), 1.965 (95th) mg/m3
21
11
TWA
Listed as "surface coating, painting" within electrical engineering, fine
mechanics, and optics manufacturing. Additional details are not pro-
vided,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
371

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
372

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electrical engineering, fine mechanics, optics
vapor
Inhalation
0.95 (50th), 11.9 (90th), 12 (95th) mg/m3
21
8
TWA
Listed as "cleaning" within electrical engineering, fine mechanics, and
optics manufacturing. Additional details are not provided.
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
373

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
374

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Processing
Formulation - manufacture /processing of coatings, glue, adhesives
vapor
Inhalation
0.4 below LOD (50th), 4.5 (90th), 6.2 (95th) mg/m3
14
8
TWA
Listed as "chemical industry and mineral processing," including manu-
facture /processing of coatings, glue, adhesives. Work area group listed
as "mixing, pressing." These data are likely a subset of the above data,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
375

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
376

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Processing
Manufacture /processing of plastic and plastic foam
vapor
Inhalation
0.2 below LOD (50th), 0.84 (90th), 1.72 (95th) mg/m3
14
8
TWA
Listed as "plastics and plastic foam, processing and manufacture; man-
ufacture and processing of rubber products." Work area group listed as
"Foaming." These data are likely a subset of the above data,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
377

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
378

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Processing
Manufacture /processing of plastic and plastic foam
vapor
Inhalation
0.3 below LOD (50th), 2 (90th), 2.6 (95th) mg/m3
28
13
TWA
Listed as "plastics and plastic foam, processing and manufacture; man-
ufacture and processing of rubber products." Work area group listed as
"Surface coating, painting, coating." These data are likely a subset of
the above data,
unknown
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Continued on next page
379

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION


Domain
Metric
Rating MWF* Score Comments

Metric 7: Metadata Completeness
Low X 1 3 The monitoring study does not address variability or uncer-
tainty
Overall Quality Determination^
Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
380

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Gluing
vapor
Inhalation
0.85 (50th), 6.15 (90th), 8.625 (95th) mg/m3
15
8
TWA
Work group area is listed as "Gluing." No additional details are provided,
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or





OSHA, but seems acceptable.
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
Low
x 2
6
unknown if in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1 3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1 3
The monitoring study does not address variability or uncer-
tainty


Continued on next
page

381

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source
Occupational Exposure; Monitoring Data;

Hero ID
4271620

EVALUATION


Domain
Metric Rating
MWF* Score Comments
Overall Quality Determination^ Medium
2.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
382

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
woodworking, paper, printing
vapor
Inhalation
50th percentile: below analytical quantification limit of 0.4290th per-
centile: 6.7695th percentile: 26
28
17
TWA
Listed as "woodworking, paper, printing"
area
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
383

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
384

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	4271620
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
woodworking, paper, printing
vapor
Inhalation
50th percentile: below analytical quantification limit of 0.4290th per-
centile: 12.5695th percentile: 120.6
14
9
TWA
Listed as "woodworking, paper, printing"
personal
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology not specified as NIOSH or
OSHA, but seems acceptable.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Medium
X 1
x 2
x 2
x 1
2
2
2
2
Germany
in scope
2010
Distribution of samples is characterized by a range with uncer-
tain statistics.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Monitoring data include sample type (e.g., personal breathing
zone) but lack other metadata.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
The monitoring study does not address variability or uncer-
tainty
Continued on next page
385

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
IFA. 2010. MEGA evaluations for the preparation of REACH exposure scenarios for N-methyl-2-pyrrolidone (vapour).
Occupational Exposure; Monitoring Data;
4271620
EVALUATION

Domain
Metric Rating MWF* Score Comments

Overall Quality Determination^ Medium 1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
386

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	NIOSH. 1998. Health Hazard Evaluation Report No. HETA 9602662702, Cooper Engineered Products, Bowling Green, Ohio.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	4287129
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
spray application of coating
Inhalation
0.04-5.2 mg/m3
unknown
1
unknown
workers inside spray booth
personal
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
Medium
x 1
2
characterized by a range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
387

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	NIOSH. 1998. Health Hazard Evaluation Report No. HETA 9602662702, Cooper Engineered Products, Bowling Green, Ohio.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	4287129
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
spray application of coating
Inhalation
0.04-0.62 mg/m3
unknown
1
unknown
workers outside spray booth
personal
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
Medium
x 1
2
characterized by a range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
388

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	NIOSH. 1998. Health Hazard Evaluation Report No. HETA 9602662702, Cooper Engineered Products, Bowling Green, Ohio.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	4287129
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
spray application of coating
Inhalation
18.6 101 mg/m3
unknown
1
unknown
inside spray booth
area
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
Medium
x 1
2
characterized by a range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
389

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	NIOSH. 1998. Health Hazard Evaluation Report No. HETA 9602662702, Cooper Engineered Products, Bowling Green, Ohio.
Type of Data Source Occupational Exposure; Completed Exposure or Risk Assessments;
Hero ID	4287129
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Use
spray application of coating
Inhalation
0.04-0.81 mg/m3
unknown
1
unknown
outside spray booth
area
unknown
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
Medium
x 1
2
characterized by a range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty of results
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
390

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.0057- <0.083 ppmTWA: <0.0057 -
<0.006 ppm
5
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Container changeout: various sizes
Personal
2-20 minutes
55- gallon drum changeouts can occur once every other week to 16 times
in a 12-hour shift
Typical chemical delivery systems are enclosed units equipped with local
exhaust ventilation, leak detection, and exhaust monitoring with alarm
to a central control room or personnel.
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; OSHA PV2043, SOP-5, GC-FID; mod. NIOSH 1302
EVALUATION




Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
High
X 1 1
US
Continued on next page
391

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5: Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^	High	1.0
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
392

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.0023 - <3 ppmTWA: <0.08 - <0.762
ppm
15
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Container changeout: various sizes
Personal
2-20 minutes
55- gallon drum changeouts can occur once every other week to 16 times
in a 12-hour shift
Typical chemical delivery systems are enclosed units equipped with local
exhaust ventilation, leak detection, and exhaust monitoring with alarm
to a central control room or personnel.
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; OSHA PV2043, SOP-5, GC-FID; mod. NIOSH 1302
EVALUATION




Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
High
X 1 1
US
Continued on next page
393

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5: Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^	High	1.0
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
394

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.2 - <0.39 ppmTWA: <0.011 - <0.19
ppm
12
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Container changeout: various sizes
Personal
2-20 minutes
55- gallon drum changeouts can occur once every other week to 16 times
in a 12-hour shift
Typical chemical delivery systems are enclosed units equipped with local
exhaust ventilation, leak detection, and exhaust monitoring with alarm
to a central control room or personnel.
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; OSHA PV2043, SOP-5, GC-FID; mod. NIOSH 1302
EVALUATION




Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
High
X 1 1
US
Continued on next page
395

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5: Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^	High	1.0
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
396

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.9 ppmTWA: <0.1 ppm
1
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Container changeout and waste handling: NOWPAK bladder removal
prior to disposal.
Personal
2-20 minutes
55- gallon drum changeouts can occur once every other week to 16 times
in a 12-hour shift
Typical chemical delivery systems are enclosed units equipped with local
exhaust ventilation, leak detection, and exhaust monitoring with alarm
to a central control room or personnel.
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; OSHA PV2043, SOP-5, GC-FID; mod. NIOSH 1302
EVALUATION




Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
High
X 1 1
US
Continued on next page
397

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5: Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^	High	1.0
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
398

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.49 ppmTWA: <0.013 ppm
1
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Container changeout and waste handling: Waste drum Disconnect, Re-
moval, Handling (55 gal)
Personal
2-20 minutes
55- gallon drum changeouts can occur once every other week to 16 times
in a 12-hour shift
Typical chemical delivery systems are enclosed units equipped with local
exhaust ventilation, leak detection, and exhaust monitoring with alarm
to a central control room or personnel.
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; OSHA PV2043, SOP-5, GC-FID; mod. NIOSH 1302
EVALUATION




Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Sampling or analytical methodology is an approved OSHA or
NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
High
X 1 1
US
Continued on next page
399

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5: Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^	High	1.0
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
400

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.006 - <0.20 ppmTWA: <0.0057-<0.20
ppm
18
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Maintenance activities: Plate cleans, filter changes, tool PMs, tool clean-
ing, o-ring changeout
Personal
The task takes from less than 12 minutes to less than or equal to 2 hours
Performed fewerthan 1 time per month per tool
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Continued on next page
401

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Semiconductor Industry Association (SIA).
Occupational Exposure; Monitoring Data;
5161295
2019.
NMP Supplemental Data: Container Handling.
EVALUATION
Domain
Metric
Rating MWF*
Score Comments

Metric 5: Sample Size
High
x 1
1 Discrete data points provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
402

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.024 - 0.29 ppmTWA: <0.001-<0.13 ppm
12
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Maintenance activities
Personal
The task takes from less than 12 minutes to less than or equal to 2 hours
Performed fewerthan 1 time per month per tool
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Metric 5:
Sample Size
High
x 1
1
Discrete data points provided
Continued on next page
403

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Semiconductor Industry Association (SIA).
Occupational Exposure; Monitoring Data;
5161295
2019.
NMP Supplemental Data: Container Handling.
EVALUATION
Domain
Metric
Rating MWF*
Score Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination^
High

1.0

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
404

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.18 - <1 ppmTWA: <0.003 - <0.18 ppm
9
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Maintenance activities: Tool PMs and dip tube changeout on chem de-
livery system
Personal
The task takes from less than 12 minutes to less than or equal to 2 hours
Performed fewerthan 1 time per month per tool
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Metric 5:
Sample Size
High
x 1
1
Discrete data points provided
Continued on next page
405

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High X 1	1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
406

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.2 - <1 ppmTWA: <0.0095 - <0.37
6
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Maintenance activities: wet station cleand and parts clean using 100
percent NMP
Personal
The task takes from less than 12 minutes to less than or equal to 2 hours
Performed fewerthan 1 time per month per tool
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Metric 5:
Sample Size
High
x 1
1
Discrete data points provided
Continued on next page
407

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High X 1	1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
408

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.0038 - <0.20 ppmTWA: <0.0036 - <0.20
28
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Fab Worker: Production operators of tools using NMP and maintenance
technicians
Personal and area
Fab operators and technicians typically work in the fab 10.5 hours of a
12-hour shift.
Daily
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID; OSHA 7
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Continued on next page
409

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Semiconductor Industry Association (SIA).
Occupational Exposure; Monitoring Data;
5161295
2019.
NMP Supplemental Data: Container Handling.
EVALUATION
Domain
Metric
Rating MWF*
Score Comments

Metric 5: Sample Size
High
x 1
1 Discrete data points provided
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
410

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured Exposure Range: <0.013 - <0.14 ppmTWA: N/A
9
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Fab Area Monitoring (near tools that use NMP in process)
Personal and area
Fab operators and technicians typically work in the fab 10.5 hours of a
12-hour shift.
Daily
Semiconductor fab workers wear long sleeved coveralls with hoods and
boots as well as gloves and safety glasses that provide ?98 percent
skin coverage. Personal protective equipment such as chemical resis-
tant aprons and gloves, face shields, and respiratory protection are used
when necessary to further reduce worker exposure.
NIOSH 1302; mod. NIOSH 1302 - GC/FID; PV2043; OSHA PV2043 -
SOP-5, GC-FID; OSHA 7
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Metric 5:
Sample Size
High
x 1
1
Discrete data points provided
Continued on next page
411

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5161295
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High X 1	1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination1
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
412

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured: <0.4 ppmTWA: <0.35 ppm
1
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Waste truck loading: Transfer of approximately 5,000 gallons of NMP
waste from a 10,000 gallon tank to a tanker truck.
Personal
2	to 4 hours
Tasks are performed by one employee and the truck driver. The employee
wears safety glasses and face shield, PVC apron with sleeves, long pants
and work boots, and Trionic gloves,
mod. NIOSH 1302 - GC/FID BADGE
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Sampling or analytical methodology is an approved OSHA or






NIOSH method
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
In scope
Metric 4:
Temporal Representativeness
High
X
2
2
Data from 2018
Metric 5:
Sample Size
High
X
1
1
Discrete data points provided
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Raw data provided and is well-described by metadata
Continued on next page
413

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Semiconductor Industry Association (SIA).
Occupational Exposure; Monitoring Data;
5161295
2019. NMP Supplemental Data: Container Handling.
EVALUATION
Domain
Metric
Rating MWF* Score Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High X 1 1 well characterized
Overall Quality Determination1
High 1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
414

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Semiconductor Industry Association (SIA). 2019. NMP Supplemental Data: Container Handling.
Occupational Exposure; Monitoring Data;
5161295
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
PPE:
Analytic Method:
Use
Electronics semiconductors
Vapor
Inhalation
Measured: 1.2 ppmTWA: 1.18 ppm
1
14 total sites sampled in study
Full shift TWA (8 or 12 hours)
Virgin NMP truck off-loading: Pull 6 samples for purity analysis; trans-
fer of virgin NMP from a 10,000 gallon tanker truck to a 10,000 gallon
tank in the tank farm. Turn on pump; stay in enclosure upstairs during
2	hour transfer.
Personal
2 to 4 hours
Tasks are performed by one employee and the truck driver. The employee
wears safety glasses and face shield, PVC apron with sleeves, long pants
and work boots, and Trionic gloves,
mod. NIOSH 1302 - GC/FID BADGE
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Sampling or analytical methodology is an approved OSHA or





NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
Data from 2018
Metric 5:
Sample Size
High
x 1
1
Discrete data points provided
Domain 3: Accessibility/Clarity
Continued on next page
415

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Semiconductor Industry Association (SIA).
Occupational Exposure; Monitoring Data;
5161295
2019.
NMP Supplemental Data: Container Handling.
EVALUATION
Domain
Metric
Rating MWF*
Score Comments

Metric 6: Metadata Completeness
High
x 1
1 Raw data provided and is well-described by metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1 well characterized
Overall Quality Determination^
High

1.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
416

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Kemira. 2018. RE: N-Methylpyrrolidone (NMP) (CASRN 872-50-4). EPA-HQ-OPPT-2016-0743-0085.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
5176404
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Chemical processing, excluding formulation (polymer manufacturing)
PPE:	chemical resistant jacket, gloves, goggles and a face shield
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^	High	1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
417

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	FUJIFILM Electronics Materials USA Inc.. 2017. NMP Use/Application Survey FFEM/FEUP. EPA-HQ-OPPT-2016-0743-
0024.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5176406
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Engineering Control & percent Exposure Reduction:
PPE:
Use
Electronics - semiconductor manufacturing
Enclosed process; In many cases, operations are conducted in class 100
or class 10 clean rooms.
Safety Glasses, impervious gloves, protective clothing with respirators if
required
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
418

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Saft American Inc.. 2017. Memorandum to EPA: N-methylpyrrolidone, docket ID number EPA-HQ-OPPT-2016-0743. EPA-
HQ-OPPT-2016-0743-0005.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176407
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Worker Activity:
Engineering Control & percent Exposure Reduction:
PPE:
Use
Electronics - batteries
Workers may also be potentially exposed during dilution, mixing, or
sampling of solutions containing NMP,
totally or partially enclosed and equipped with ventilation
face shields, gloves, and chemical resistant clothing
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
No Comment.
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
419

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electronics
vapor
Inhalation
Range: less than the detection limit to 0.202 mg/m3
unknown
unknown
full-shift TWA
Wafer stripping ("cleaning") removing photoresist. Wafer cleaning for
organics removal. Operations are in a closed processing system,
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Methodology is stated and seems legitimate
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
EU
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2003 - 2011
Metric 5:
Sample Size
Medium
x 1
2
range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
lacks exposure duration and frequency
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium

1.8

Continued on next page
420

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
421

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electronics
vapor
Inhalation
Range: 0.0247 to 0.857 mg/m3
unknown
unknown
full-shift TWA
Photolithography layer spin-on. Polyimide deposition. Operations are
in a closed processing system.
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Methodology is stated and seems legitimate
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
EU
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2003 - 2011
Metric 5:
Sample Size
Medium
x 1
2
range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
lacks exposure duration and frequency
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium

1.8

Continued on next page
422

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
423

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electronics
vapor
Inhalation
Range: less than the detection limit to 0.770 mg/m3
unknown
unknown
full-shift TWA
Preventive maintenance at process equipment tools in the cleanroom.
Invasive maintenance.
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Methodology is stated and seems legitimate
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
EU
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2003 - 2011
Metric 5:
Sample Size
Medium
x 1
2
range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
lacks exposure duration and frequency
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium

1.8

Continued on next page
424

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
425

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Use
Electronics
vapor
Inhalation
Range: less than the detection limit to 4.054 mg/m3
unknown
unknown
full-shift TWA
Chemicals storage and delivery areas open to ambient air. Canister,
bottle and container change at tools and chemfill stations not in the
cleanroom.
personal
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Methodology is stated and seems legitimate
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
EU
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2003 - 2011
Metric 5:
Sample Size
Medium
x 1
2
range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
lacks exposure duration and frequency
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Continued on next page
426

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176408
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

Medium 1.8


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
427

N/A
No Comment.
Overall Quality Determination^
High

1.1

Continued on next page
428

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Celanese Engineered Materials. 2017. N-methylpyrrolidone (NMP) CASRN: 872-50-4, use, disposal and exposure scenarios.
EPA-HQ-OPPT-2016-0743-0015.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5176410
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
429

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Akin Gump Strauss Hauer & Feld LLP. 2018. Re: EPA docket EPA-HQ-OPPT-2016-0743: N-Methyl-2-pyrrolidone ("NMP")
CAS# 872-50-4 comments regarding the NMP problem formulation document. EPA-HQ-OPPT-2016-0743-0102.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176411
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Engineering Control & percent Exposure Reduction:
PPE:
Use
dip cleaning of plastic films
Vapor
Inhalation
Occupationalexposure levels to NMP through inhalation range from neg-
ligible to approximately 4 ppm
8-hour TWA
scrubbers or a Regenerative Thermal Oxidizer (RTO)
Neoprene gloves, long sleeve cotton uniforms with pants and/or coveralls,
safety shoes, and safety glasses. Face shields and safety goggles along
with chemical resistant aprons are utilized for tasks with liquid splash
potential
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Sampling or analytical methodology is not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Low
X 1
x 2
x 2
x 1
1
2
2
3
US
In scope
2018
qualitative or characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Unacceptable
x 1
4
Monitoring data do not include any needed metadata to un-
derstand what the data represent - i.e., PBZ or Area, Num. of
samples, worker activities
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
does not address variability or uncertainty


Continued on next
page


430

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Akin Gump Strauss Hauer & Feld LLP. 2018. Re: EPA docket EPA-HQ-OPPT-2016-0743: N-Methyl-2-pyrrolidone ("NMP"),
CAS# 872-50-4 comments regarding the NMP problem formulation document. EPA-HQ-OPPT-2016-0743-0102.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5176411
EVALUATION
Domain
Metric
Rating MWF* Score Comments

Overall Quality Determination^

Unacceptable 4 Metric Mean Score: 2.0.

** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
431

N/A
No Comment.
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
432

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Analytic Method:
Use
Paints, coatings, adhesives
Vapor
Inhalation
<5.08 mg/m3
1
duration based (50 mins)
spray paint tending
personal
8 hours workshift duration
weekly
NIOSH 1302
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
U.S. based exposure data
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Individual measurements are provided so the sample sets can





be fully statistically characterized.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
DOD data include sample type (PBZ), sample time, process
frequency, and workshift duration, worker job descriptions are
provided, but details on worker activities for remainder of shift
are unknown.
Continued on next page
433

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EVALUATION


Domain Metric
Rating
MWF* Score Comments

Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1 3 DOD data do not discuss variability or uncertainty.
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
434

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Analytic Method:
Use
Paints, coatings, adhesives
Vapor
Inhalation
<5.64 mg/m3
1
duration based (45 mins)
spray paint tending
personal
8 hours workshift duration
weekly
NIOSH 1302
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
U.S. based exposure data
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Individual measurements are provided so the sample sets can





be fully statistically characterized.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
DOD data include sample type (PBZ), sample time, process
frequency, and workshift duration, worker job descriptions are
provided, but details on worker activities for remainder of shift
are unknown.
Continued on next page
435

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EVALUATION


Domain Metric
Rating
MWF* Score Comments

Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1 3 DOD data do not discuss variability or uncertainty.
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
436

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Analytic Method:
Use
Removal
Vapor
Inhalation
<15.2 mg/m3
1
duration based (17 mins)
Using Safe Strip to Remove Plastic Covering
personal
8 hours workshift duration
2-3 times per week
NIOSH 1302
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
NIOSH method
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
U.S. based exposure data
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2015
Metric 5:
Sample Size
High
x 1
1
Individual measurements are provided so the sample sets can





be fully statistically characterized.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
DOD data include sample type (PBZ), sample time, process
frequency, and workshift duration, worker job descriptions are
provided, but details on worker activities for remainder of shift
are unknown.
Continued on next page
437

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EVALUATION


Domain Metric
Rating
MWF* Score Comments

Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1 3 DOD data do not discuss variability or uncertainty.
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
438

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID 5178607
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Exposure Duration:
Exposure Frequency:
Analytic Method:
Use
Removal
Vapor
Inhalation
11 mg/m3
1
duration based (78 mins)
Asbestos Removal - Glue removal
personal
8 hours workshift duration
special occasions
unknown
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
DOD service branches use OSHA and NIOSH methods and

DOD methods, which are expected to be equivalent to OSHA

or NIOSH methods.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
U.S. based exposure data
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2016
Metric 5:
Sample Size
High
x 1
1
Individual measurements are provided so the sample sets can
be fully statistically characterized.
Domain 3: Accessibility/Clarity
Continued on next page
439

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Defense Occupational and Environmental Health Readiness System - Industrial Hygiene (DOEHRS-IH). 2018. Email between
DOD and EPA: RE: [Non-DoD Source] Update: DoD exposure data for EPA risk evaluation - EPA request for additional
information. U.S. Department of Defense.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5178607
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments

Metric 6: Metadata Completeness
Medium
X 1
2
DOD data include sample type (PBZ), sample time, process
frequency, and workshift duration, worker job descriptions are
provided, but details on worker activities for remainder of shift
are unknown.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1
3
DOD data do not discuss variability or uncertainty.
Overall Quality Determination^
High

1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
440

-------
Facility
PEER REVIEW DRAFT
DO NOT CITE OR QUOTE
441

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Cory, N. J.. 2002. An update on environmental constraints. American Leather Chemists Association. Journal.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
2874538
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Polymer solvent; leather finishing
Process Description: NMP is used as a solvent for urethane polymerization. It is found in
residual cocentrations in polyurethane coatings used for leather finishing.
NMP has been found in auto leather at concentrations up to averaging
3,000 mg/kg. Studies on boot leather have demonstrated significantly-
lower NMP concentrations ranging from 200 to 600 mg/kg.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X
1
3
The data, data sources, and/or techniques used in the assess-
ment or report are not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X
X
X
X
1
2
2
1
1
2
4
3
US
In scope
2002
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Unacceptable
X
1
4
Assessment or report does not document its data sources, as-
sessment methods, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.2.
Continued on next page
442

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Cory, N. J.. 2002. An update on environmental constraints. American Leather Chemists Association. Journal.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	2874538
EVALUATION
Domain	Metric	Rating	MWF* Score	Comments
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
443

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Solomon, G. M.,Morse, E. P.,Garbo, M. J.,Milton, D. K.. 1996. Stillbirth after occupational exposure to N-methyl-2-
pyrrolidone: A case report and review of the literature. Journal of Occupational and Environmental Medicine.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3043623
EXTRACTION
Parameter Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Laboratory
Process Description:
Batch Size:

NMP used to dissolve solid samples (negative photoresist), which is an-
alyzed in atomic absorption spectrophotometers, and discarded as Haz
waste. NMP first poured from 5 gallon containers through an ion ex-
change column for filtering before use. Custom chemical manufacturer.
1 L/day
EVALUATION

Domain
Metric
Rating MWF* Score Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium X 1 2 Prom an industry contact
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Use is in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1996 - more than 20 years old
Metric 5:
Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness High x 1 1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty of results
Overall Quality Determination^
Medium
1.8

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3539720
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Possible Physical Form:
Chemical Concentration:
Use
Adhesive formulation facility
NMP was applied for the manual cleaning of mixing and stirring vessels
(500 1 volume) and of smaller parts such as drain valves and tools. After
the mixing of the basic compounds ( 2 h), the vessels are emptied and the
stirrers and upper parts of the mixers are cleaned manually with brushes
and wiping cloths. The vessels are then disassembled and cleaned for
about 30 min with brushes and cloths together with inlets, drain valves
and other fittings,
liquid
65 percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom an industry contact
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
N/A
X 1
x 2
x 2
2
2
4
N/A
Germany
Use is in scope
2006
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability or uncertainty.
Continued on next page
445

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Bader, M.,Rosenberger, W.,Rebe, T.,Keener, S. A.,Brock, T. H.,Hemmerling, H. J.,Wrbitzky, R.. 2006. Ambient moni-
toring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility. International Archives of
Occupational and Environmental Health.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3539720
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

Medium 1.8


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
446

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Degreasing optical lenses
Process Description: The lenses were washed in a room with a large washing chamber (1 m x
I m x 2.5 m). Four workers were engaged in the washing process.Fifty
lenses were put in a special container basket. Workers opened a door of
the chamber to dip the basket into a pool containing NMP inside the
chamber. After closing the door, sonication was started to wash the
lens surfaces. This washing process lasted for 5 min. After washing, the
baskets were lifted from the pool and then dried outside the chamber for
a couple of minutes.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From an industry contact
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
N/A
X 1
x 2
x 2
2
2
4
N/A
Japan
Degreasing is in scope
2000
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability or uncertainty.
Overall Quality Determination^
Medium

1.8

Continued on next page
Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3562767
447

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3562767
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
448

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3562767
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Degreasing metal parts
They put more than 100 parts in a basket, opened the cover of a tank
containing NMP and dumped the basket into the tank. The lid of the
container was then closed. After 30 min of soaking in NMP, the basket
was lifted out and immediately transferred to a tank containing water.
Some drops adhering to the parts and baskets were scattered over the
floor. Other drops were carried into the water tank. NMP evaporated
into the washing room air from the contaminated floor and water tank.
Eight workers were engaged in this process.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
From an industry contact
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Japan
Metric 3:
Applicability
High
x 2
2
Degreasing is in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3 Does not address variability or uncertainty.
Overall Quality Determination^
Medium
1.8
Continued on next page
449

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Xiaofei, E.,Wada, Y.,Nozaki, J.,Miyauchi, H.,Tanaka, S.,Seki, Y.,Koizumi, A.. 2000. A linear pharmacokinetic model predicts
usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure.
Journal of Occupational Health.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3562767
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
450

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Muenter, J.,Blach, R.. 2010. ECOLOGICAL TECHNOLOGY: NMP-FREE LEATHER FINISHING. American Leather
Chemists Association. Journal.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3577026
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Coating - polymeric for leather finishing
NMP eased the production of binders and the application on lemher.
NMP influences the viscosity and even the rheology. When NMP is
used in leather finishing almost 90 percent remains in the leather after
drying, but is gradually released over a long period of time.
0-7.1 percent
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Medium x 1
The assessment or report uses high quality data and/or tech-
niques that are not from trusted sources; however, Associated
information does not indicate flaws or quality issues.
Domain 2: Representative
Metric 2: Geographic Scope
Medium
X
1
2
Germany
Metric 3: Applicability
High
X
2
2
in scope
Metric 4: Temporal Representativeness
High
X
2
2
2010
Metric 5: Sample Size
Medium
X
1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
Medium
X
1
2
Assessment or report clearly documents results, methods, and

assumptions. Data sources are generally described but not

fully transparent.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
High
X
1
1
The report addresses variability and uncertainty in the results.

Uncertainty is well characterized
Overall Quality Determination^
High

1.4

Continued on next page
451

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Muenter, J.,Blach, R.. 2010. ECOLOGICAL TECHNOLOGY:
NMP-FREE LEATHER FINISHING. American Leather

Chemists Association. Journal.

Type of Data Source
Facility; Reports for Data or Information Other than Exposure or
Release Data;
Hero ID
3577026

EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
452

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Lammens, T. M.,Potting, J.,Sanders, J. P. M.,De Boer, I. J. M.. 2012. Environmental comparison of biobased chemicals from
glutamic acid with their petrochemical equivalents. International Sugar Journal.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3578330
EXTRACTION
Parameter Data
Life Cycle Stage: Manufacture
Life Cycle Description (Subcategory of Use): Manufacturing
Total Annual U.S. Volume (and percent of PV): 100-150 kton
EVALUATION

Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High x 1 1
Information from journal articles
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Manufacturing is in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2010
Metric 5:
Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness High x 1 1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 Does not address variability or uncertainty for this data ele-
ment
Overall Quality Determination1
High

1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Eu,. 2007. Impact assessment of potential restrictions on the marketing and use of dichloromethane in paint strippers. Revised
final report-Annexes.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3808951
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Paint stripper
Paint strippers are used to remove various coats of paints especially
blistered or cracked coats on wood both indoors and outdoors. NMP
cannot be used for polyester or bakedon coatings.
2.5-63 percent
EVALUATION

Domain
Metric
Rating
MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1 Trusted sources

Domain 2: Representative
Metric 2: Geographic Scope
Medium
X
1
2
OECD member states
Metric 3: Applicability
High
X
2
2
in scope
Metric 4: Temporal Representativeness
Medium
X
2
4
2007
Metric 5: Sample Size
Medium
X
1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
High
X
1
1
Assessment or report clearly documents its data sources, as-

sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
High
X
1
1
The report addresses variability and uncertainty in the results.

Uncertainty is well characterized
Overall Quality Determination^
High

1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
ECHA. 2011. Annex XV dossier. Proposal for Identification of a Substance as a CMR Cat 1A or IB, PBT, vPvB or a
Substance of an Equivalent Level of Concern.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3809417
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Processing
Chemical processing, excluding formulation (petrochemical extraction)
NMP is used in the large-scale recovery of hydrocarbons by extractive
distillation. Hydrocarbons are highly soluble in NMP and differences in
volatility are sometimes considerably increased in the presence of NMP
(BASF, 2010). NMP is used particularly because, unlike other commer-
cial solvents and extraction media, its use does not lead to the formation
of azeotropeslO and because NMP has high resistance to heat and chem-
icals.
Based on data from OECD (2007), historical use in this application was
estimated as 10 percent of global use. If the same is true for current use
in the EU, the total use in this application could be around 1,000 -5,000
t/y.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
ECHA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
Europe
In scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Continued on next page
455

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	ECHA. 2011. Annex XV dossier. Proposal for Identification of a Substance as a CMR Cat 1A or IB, PBT, vPvB or a
Substance of an Equivalent Level of Concern.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3809417
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

High 1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
456

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
ECHA. 2011. Annex XV dossier. Proposal for Identification of a Substance as a CMR Cat 1A or IB, PBT, vPvB or a
Substance of an Equivalent Level of Concern.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3809417
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Processing
Chemical processing, excluding formulation (pharmaceutical extraction
medium)
According to the OECD (2009) SIDS dossier, NMP is used as a pen-
etration enhancer for a more rapid transfer of substances through the
skin. Use as a solvent and extraction medium is reported by indus-
try (Taminco, 2010). There is limited information that suggests NMP
could be used as a solvent during the preparation of pharmaceuticals as
well as being present in some pharmaceutical products (Jouyban et al,
2010). These authors state that NMP is one of the main pharmaceutical
co-solvents and that it is an important solvent used in the extraction,
purification and crystallisation of drugs. It is not known whether NMP
is used in this way within the EU.
No comprehensive information is available on quantities of NMP cur-
rently used in the EU in pharmaceuticals. However, based on the global-
level percentage split of uses from several years ago (15 percent ) and
the assumed quantity used in the EU (10,000 -50,000 t/y), it can be
estimated that perhaps 1,500 to 7,500 tonnes of NMP are used in this
application each year.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
ECHA
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Europe
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Continued on next page
457

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
ECHA. 2011. Annex XV dossier. Proposal for Identification of a Substance as a CMR Cat 1A or IB, PBT, vPvB or a
Substance of an Equivalent Level of Concern.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3809417
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High	x 1	1 Data sources included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A
N/A This metric is not applicable to this data type
Overall Quality Determination^
High
1.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
458

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
A. L. Harreus, R. Backes, J. O. Eichloer, R. Feuerhake, C. Jakel, U. Mahn, R. Pinkos, R. Vogelsang. 2011. 2-Pyrrolidone.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3809424
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Possible Physical Form:
Chemical Concentration:
Manufacture
Manufacture
Large-scale production of NMP is predominantly carried out by reacting
?-butyrolactone with an excess of pure or aqueous methylamine in a high-
pressure tube reactor (612 MPa). The reaction is exothermic and often
run under adiabatic conditions with reactor temperatures in the range of
250400 "C. The resulting product mixture is decompressed and distilled.
The NMP yield is normally more than 97 percent [27]. Other processes,
e.g., analogous to those used for pyrrolidone synthesis can also be used, in
particular hydrogenation of N-methylsuccinimide or mixtures of maleic
or succinic anhydride and methylamine [28]. NMP can also be produced
by hydrogenation of N-hydroxymethyl- 2-pyrrolidone (see Chap. 2) [29]
or by reaction of acrylonitrile with methylamine in the presence of a
peroxide radical initiator [30].
liquid
NMP content, min.99.5 wt percent ; methylamine, max. 0.02 wt percent
; water,max. 0.1 wt percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Ullmann's Encyclopedia of Industrial Chemistry
Domain 2: Representative

Metric 2:
Geographic Scope
Medium
X 1
2
Germany
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
x 1
1
Data sources included
Continued on next page
459

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	A. L. Harreus, R. Backes, J. O. Eichloer, R. Feuerhake, C. Jakel, U. Mahn, R. Pinkos, R. Vogelsang. 2011. 2-Pyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3809424
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Medium X 1	2 Limited information on concentration variability
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
460

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Nicnas,. 2013. Human health Tier II assessment for 2-pyrrolidinone, 1-methyl, CAS Number 872-50-4.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3809432
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Domestic paint and varnish remover
Chemical Concentration:	up to 100 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Low
High
N/A
X 1
x 2
x 2
1
6
2
N/A
US
a non-occupational scenario that is similar to an occupational
scenario
2011-2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability or uncertainty for this data ele-
ment
Overall Quality Determination^
Medium

1.8


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
461

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Nicnas,. 2013. Human health Tier II assessment for 2-pyrrolidinone, 1-methyl, CAS Number 872-50-4.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3809432
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Domestic cleaning products
Chemical Concentration:	5 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Low
High
N/A
X 1
x 2
x 2
1
6
2
N/A
US
a non-occupational scenario that is similar to an occupational
scenario
2011-2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability or uncertainty for this data ele-
ment
Overall Quality Determination^
Medium

1.8


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
462

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Facility; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacturing
The production of NMP and associated bulk transfers and storage is
contained within closed systems.Processes involved are the use in closed
systems (PROC1-2-3), the transfer of NMP after production (charging
and discharging, see below under generic use), sampling and maintenance
and cleaning.
60,000 80,000 tonnes/yr
3 US Sites (2007)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
Low
x 1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty
Overall Quality Determination^
High
1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
463

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID 3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Processing
Formulation
mixing in batch or continuous processes and further processing steps
such as transfers, storage and packing. Such processes might occur in
closed systems. In the industrial setting elevated temperatures can be
used.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
464

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID 3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Petrochemical
NMP is used in the large-scale recovery of hydrocarbons by extractive
distillation. Hydrocarbons are highly soluble in NMP. NMP is used in
the desulfurization of oil products, the removal of C02, COS and H2S
from gas streams and in butadiene production.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter

Data


Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Use
Coatings, Paints, adhesive, varnish, etc.
NMP is used as a solvent in a wide range of different coating products.
NMP is often used in polymer based coatings, such as wire coatings.
The characteristics are favourable for baked coatings that are cured at
relatively high temperatures (BASF, 2010). The use in coatings may be
under elevated temperatures up to 120 " C. The processes involved in the
use of non-wire coatings are in general open processes involving dipping,
rolling, spraying and curing/drying of the coatings.
2,220-4,280 tonnes/yr (Europe)
0.06 13 (paint); 13 68 (paint remover); 0.06 2 (polish); 1-10 (adhesive)
EVALUATION
Domain
Metric
Rating
MWF* Score
i Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1 1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
Low
x 1 3
x 2 2
x 2 2
x 1 3
Europe
in scope
2013
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1 1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1 1
Discussion on variability and uncertainty
Overall Quality Determination^
High
1.4

Continued on next page
466

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Facility; Completed Exposure or Risk Assessments;
3809440

EVALUATION
Domain
Metric Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
467

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Facility; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Use
Cleaning
NMP is used as an ingredient in paint removers, cleaners and as or in
degreasers. It can be used in pure form or in mixtures. Industrially, it
can be used under elevated temperatures.
60-95 tonnes/yr
30-60 percent
EVALUATION

Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1: Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative

Metric 2: Geographic Scope
Low
X
1
3
Europe
Metric 3: Applicability
High
X
2
2
in scope
Metric 4: Temporal Representativeness
High
X
2
2
2013
Metric 5: Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty
Overall Quality Determination1
High

1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID 3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Cleaning and coating in the Electronics industry
Wafer cleaning and stripping to remove organic contamination and or-
ganic layers. And, as a solvent in dedicated formulations (i.e. precursor
solutions for wafer coatings such as polyimides and anti-reflective coat-
ings) .
<5 tonnes/yr
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
Low
x 1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High x 1
1 Discussion on variability and uncertainty
Overall Quality Determination1
High
1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data



Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Electronics
A photoresist carrier solvent. A photoresist stripper.
10-100 tonnes/yr per site
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
Low
High
High
Low
X 1
x 2
x 2
x 1
3
2
2
3
Europe
in scope
2013
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty
Overall Quality Determination^
High

1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
470

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source Facility; Completed Exposure or Risk Assessments;
Hero ID	3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Battery
In lithium battery production it is applied as a solvent for the binder
resins for both the carbon anode and the lithium cobalt oxide cathode, it
may be used in gel-polymer lithium ion battery separators/electrolytes,
and it may be used in coatings on the outside of the batteries.
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
Low
X
1
3
Europe
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2013
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
471

Parameter
Data
Life Cycle Stage: Processing
Life Cycle Description (Subcategory of Use): Polymers
Process Description: NMP is used as a processing aid in the production of polymers. Immer-
sion precipitation in a solvent. Up to and including polymerization, this
use can be considered as a controlled process, though not fully closed,
but after polymerization, the resultant polymer still contains traces of
NMP that may evaporate during the production process and may cause
worker exposure. The high performance polymer end product is assumed
not to contain any remaining NMP.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
N/A
X
X
X
1
2
2
3
2
2
N/A
Europe
in scope
2013
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty
Overall Quality Determination^
High

1.3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Facility; Completed Exposure or Risk Assessments;
3809440
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Processing
Agricultural products
NMP is both used in the synthesis of active ingredients and as a co-
solvent in the formulation of various agrochemicals. In case NMP is
used in the synthesis of active ingredients, the use is fully industrial and
NMP is assumed not end up in the final product. If NMP is used as a
co-solvent, NMP will obviously be contained in the final products. The
concentration of NMP in herbicides, fungicides and pesticides is < 7
percent .
1-15 (pesticide)
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
Information from trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
Low
X 1
3
Europe
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2013
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
x 1
1
Data sources are transparent
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
Discussion on variability and uncertainty
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
473

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Rivm,. 2013. Annex XV Restriction Report: Proposal for a Restriction.
Type of Data Source
Facility; Completed Exposure or Risk Assessments;
Hero ID
3809440
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Pharmaceutical
Process Description:	In the production of pharmaceuticals, NMP is an important solvent used
in the extraction, purification, and crystallization of pharmaceuticals
(Jouyban et al 2010). BASF (2011a) further reports that it produces
high grade NMP. A number of topical formulations that may contain
NMP as a transdermal enhancer. Also the use as a solvent and as ex-
traction medium
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Information from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
N/A
X
X
X
1
2
2
3
2
2
N/A
Europe
in scope
2013
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Data sources are transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X
1
1
Discussion on variability and uncertainty
Overall Quality Determination1
High


1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
474

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Ec/Hc,. 2017. Chemicals at a glance: NMP and NEP.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827463
EXTRACTION

Parameter
Data
Life Cycle Stage: All
Life Cycle Description (Subcategory of Use): All
Process Description: NMP is used in industrial applications, as well as in products available to
consumers, including paint strippers, cosmetics, and certain food packag-
ing materials. Canadians may be exposed to these substances primarily
through products used by consumers, such as paint strippers, nail polish
remover and body lotion.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X
1
3
The data, data sources, and/or techniques used in the assess-
ment or report are not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Unacceptable
High
N/A
XXX
1
2
2
2
8
2
N/A
Canada
Not enough information to assess applicability
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
data sources are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
no discussion
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.6.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
475

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-
Methylopyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3827468
EXTRACTION
Parameter
Data

Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacturing /import
List of methods for manufacturing NMP are on page 4-5
160,818,058 lbs (2015, from 2016 CDR)
33
EVALUATION
Domain Metric
Rating
MWF*
Score Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1 trusted sources
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
High
Low
X 1
x 2
x 2
x 1
1 US
2 in scope
2 2017
3 Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 The report does not address variability or uncertainty.
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
476

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Adhesives
Chemical Concentration:	<0.3 to >85 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
477

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	cleaners
Chemical Concentration:	<1 - 100 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
478

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	coatin, paint, sealant
Chemical Concentration:	0.1-63 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
479

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	inks and dyes
Chemical Concentration:	0-98 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
480

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	pesticides
Chemical Concentration:	1-68 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
481

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Paint stripper
Chemical Concentration:	25 - <80 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
482

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-
Methylopyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3827468
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Chemical Concentration:
Use
photoresist remover
>99 percent
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
483

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	soldering flux
Chemical Concentration:	f-2.5 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	f.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
484

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-
Methylopyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3827468
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Chemical Concentration:
Use
wood preservative
<1 percent
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
485

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-

Methylopyrrolidone (NMP).
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827468
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	lithium battery
Chemical Concentration:	0-1 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
The report does not address variability or uncertainty.
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
486

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 2017. Preliminary information on manufacturing, processing, distribution, use, and disposal: N-
Methylopyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3827468
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Chemical Concentration:
Use
Plastics (Cast nylon industrial use)
<5 percent
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
trusted sources
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
487

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 1998. Environmental profile for N-methylpyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3827493
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Manufacture
Manufacture
See Section 2.1. N-methylpyrrolidone is manufactured by combining y-
butyrolactone with methylamine. NMP production is accomplished by
condensing y-butyrolactone with methylamine at 200 to 350" C and 10
MPa.
3
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
x 1
1
The assessment or report uses data or techniques that are high

quality (from trusted sources (e.g., journal articles)
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
1998
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2
The report provides only limited discussion of the variability
and uncertainty in the results.
Overall Quality Determination^
High
1.4

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Paint stripper
Chemical Concentration: 12-80 percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
The assessment or report uses data or techniques that are high
quality (from trusted sources (e.g., journal articles)
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Medium
X
X
X
X
1
2
2
1
1
2
4
2
US
in scope
1998
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X
1
2
The report provides only limited discussion of the variability
and uncertainty in the results.
Overall Quality Determination^
High

1.4

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): photoresist remover
Process Description: N-methylpyrrolidone is used in the microelectronics industry to strip
phenolic residue from packages and photoresist resins on wafer surfaces
and as a vehicle for "die-coat" application.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
The assessment or report uses data or techniques that are high
quality (from trusted sources (e.g., journal articles)
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
XXX
1
2
2
1
2
4
N/A
US
in scope
1998
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X
1
2
The report provides only limited discussion of the variability
and uncertainty in the results.
Overall Quality Determination^
High

1.4

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Type of Data Source
Facility; Completed Exposure or Risk Assessments;
Hero ID
3827504
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	Manufacture or import
Total Annual U.S. Volume (and percent of PV):	184.7 million pounds
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Data and techniques are high quality; Information from trusted
sources.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Low
X 1
x 2
x 2
x 1
1
2
2
3
US
in scope
2012-2015
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
491

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Facility; Completed Exposure or Risk Assessments;
3827504
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Possible Physical Form:
Chemical Concentration:
Use
Paint stripper
Larger facilities typically purchase in quantities ranging in size from five-
to 55-gallon drums. Smaller facilities purchase small quantities of strip-
per from hardware or paint supply stores. Techniques for paint stripping
typically include manual coating, tank dipping and spray application.
Pouring, wiping and rolling are also possible application techniques and
application can be manual or automated. After application, the strip-
per is allowed to set and soften the old coating. Once the stripper has
finished setting, the old coating is removed from the surface by scraping
and brushing. After the old coating is removed, the surface is wiped
clean before moving to the next stages of the job.
9 percent
In California, approximately 80 facilities that have stripping equipment.
500 additional facilities in the state, which would include small facilities
like antique shops
liquid
0.25 (low-end), 0.625 (mid), 1 (high-end)
EVALUATION






Domain
Metric
Rating
MWF*
Score

Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X 1
1
Data and techniques
are high quality; Information from trusted





sources.

Domain 2: Representative






Metric 2:
Geographic Scope
High
X 1
1
US

Metric 3:
Applicability
High
x 2
2
in scope

Metric 4:
Temporal Representativeness
High
x 2
2
2012-2015

Metric 5:
Sample Size
Low
x 1
3
Characterized by no
statistics
Domain 3: Accessibility/Clarity
Continued on next page
492

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
U.S, E. P. A.. 2015. TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4).
Facility; Completed Exposure or Risk Assessments;
3827504
EVALUATION
Domain
Metric
Rating
MWF* Score Comments

Metric 6: Metadata Completeness
High
X 1 1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1 1 well characterized
Overall Quality Determination^
High
1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
493

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): graffiti removal
Process Description: Solvents are either spray or brush applied. Sprayed solvents can be
swabbed or wiped with a cloth or tissue. After spraying and wiping
or brushing the solvent on the surface, the surface is then washed with
heated (70oC) wash water using a high-pressure spray.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Data and techniques are high quality; Information from trusted
sources.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
in scope with paint stripping
2012-2015
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination1
High

1.0

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3828838
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Manufacture of dyes and pigment
Process Description:	see pages 73-79 for basic, not NMP-specific process description
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
OECD
in scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
495

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3828838
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	pesticides, fertilisers and nitrogen compounds
Process Description:	see pages 73-79 for basic, not NMP-specific process description
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
OECD
in scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
496

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3828838
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Manufacture of paints, varnishes and similar coatings, printing ink
Process Description:	see pages 73-79 for basic, not NMP-specific process description
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
OECD
in scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
497

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3828838
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Manufacture of pharmaceuticals, medicinal chemicals and botanical
product
Process Description:	see pages 73-79 for basic, not NMP-specific process description
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
OECD
in scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
498

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oecd,. 2017. Emission Scenario Document (ESD) on the use of textile dyes.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3828838
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Manufacture of soap and detergents, cleaning and polishing prepara-
tions, perfumes and toiletpreparations (cosmetics)
Process Description:	see pages 73-79 for basic, not NMP-specific process description
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
OECD
in scope
2011
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
499

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
White, D. L.,Bardole, J. A..
2004. Paint and finish removers.
Type of Data Source
Facility; Reports for Data or
Information Other than Exposure or Release Data;
Hero ID
3859417

EXTRACTION

Parameter

Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Possible Physical Form:
Chemical Concentration:
Use
Paint stripper
>104 industries use finish removers. Finish removers are applied by
brushing, spraying, troweling, flowing, or soaking. Cleaning the sub-
strate may be by water rinse, wipe and let dry, or solvent rinse. Re-
movers may be neutral, basic, or acidic. The viscosity may be water
thin, thick enough to spray-on and cling, or a paste to be troweled on.
liquid; semipaste, water rinse finishremover
optimal = 40 to 50 mole percent ; Typical solution = 15 to 27.5wt
percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X 1
1
From trusted sources
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2006
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
High
x 1
1
addresses variability and uncertainty
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
500

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
White, D. L.,Bardole, J. A..
2004. Paint and finish removers.
Type of Data Source
Facility; Reports for Data or
Information Other than Exposure or Release Data;
Hero ID
3859417

EXTRACTION


Parameter

Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Processing
formulation of paint strippers
Finish removers may be manufactured in open or closed kettles. Closed
kettles are prefered because they prevent solvent loss and exposure to
personnel. To reduce emissions, condenser are often employed on vent
stacks. Mild steel or black iron kettles are used for neutral or basic
removers; stainless steel or reinforced polyethylene kettles are used for
acidic removers. The kettles are heated to aid dispersion of paraffin
waxes and mixing of other ingredients. Steel and polypropylene drums
are used for industrial removers.
There are about 51 paint remover manufacturers in the United States.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
From trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
2006
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
addresses variability and uncertainty
Overall Quality Determination^
High

1.3

Continued on next page
501

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
White, D. L.,Bardole, J. A.. 2004. Paint and finish removers.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3859417

EVALUATION
Domain
Metric Rating MWF* Score
Comments

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
502

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Ashford, R. D.. 2001. Ashford's Dictionary of Industrial ChemicalsN-methylpyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3860437
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Manufacture
Manufacture
N-methylpyrrolidone is manufactured by combining ?-butyrolactone
with methylamine. NMP is used in chemical synthesis, pretrochemical
extractions (aromatics, acetylene, butadiene), lubricating oil dearomati-
zation, paint removers, and coatings.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
The data, data sources, and/or techniques used in the assess-
ment or report are not specified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
N/A
X 1
x 2
x 2
2
2
4
N/A
UK
in scope
2001
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Unacceptable
x 1
4
Assessment or report does not document its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.1.

** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
503

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:
Manufacture
Life Cycle Description (Subcategory of Use):
Manufacturing or Import
Total Annual U.S. Volume (and percent of PV):
>842,712 (import); >701,048 (mfg)
Number of Sites:
22 total, >15(import), >5 (mfg)
Possible Physical Form:
liquid
Chemical Concentration:
100 percent
EVALUATION

Domain Metric
Rating MWF* Score Comments
Domain 1: Reliability

Metric 1: Methodology
High X 1 1 Trusted source - CDR data
Domain 2: Representative
Metric 2:	Geographic Scope	High	x 1	1
Metric 3:	Applicability	High	x 2	2
Metric 4:	Temporal Representativeness	High	x 2	2
Metric 5:	Sample Size	Low	x 1	3
US
in scope
2011-2012
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3 no discussion
Overall Quality Determination^
High
1.4

* MWF = Metric Weighting Factor
r If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
504

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Flero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Commercial cleaning of Fabric, Textile, and Leather Products
Possible Physical Form:	liquid
Chemical Concentration:	< 1 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
in scope
2011-2012
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
no discussion
Overall Quality Determination^
High


1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
505

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: 2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or
Hero ID 3860463
Release Data;
EXTRACTION
Parameter
Data



Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Possible Physical Form:
Chemical Concentration:
Manufacture
Import
From 2012 CDR, 7/15 sites chemical is never at site and 8/15 report
on-site
>15
liquid
100 percent
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
in scope
2011-2012
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination1
High

1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
506

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Consumer paint and coatings
Possible Physical Form:	liquid
Chemical Concentration:	< 1 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Low
x 2
6
Non-occupational scenario - information on wt. fraction can





be applied to occupational scenario
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
507

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Batteries
Possible Physical Form:	liquid
Chemical Concentration:	90 percent +
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Trusted source - CDR data
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
in scope
2011-2012
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
no discussion
Overall Quality Determination^
High


1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
508

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Commerical cleaning products for Electrical and Electronic Products
Possible Physical Form:	liquid
Chemical Concentration:	30 percent - < 60 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
509

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	metal products not covered elsewhere
Possible Physical Form:	liquid
Chemical Concentration:	60 percent - < 90 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Medium
x 2
4
Unsure of scenario, could be metal fininshing or could be out





of scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5: Sample Size	Medium X 1	2 Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 no discussion
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
510

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Commerical use of Electrical and Electronic Products
Possible Physical Form:	liquid
Chemical Concentration:	30 percent - < 60 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Medium
x 2
4
Unsure of scenario, could be metal fininshing or could be out





of scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5: Sample Size	Medium X 1	2 Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1 clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 no discussion
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
511

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2017. Chemical data reporting: l-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860463
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	commerical adhesives and sealants
Possible Physical Form:	liquid
Chemical Concentration:	60 percent - < 90 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Trusted source - CDR data
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011-2012
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
512

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
2017. PubChem: l-Methyl-2-pyrrolidinone.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3860487
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Manufacture
Manufacturing
Large-scale production of NMP is predominantly carried out by reacting
gamma-butyrolacetone with an excess of pure or aqueous methyamine in
a high-pressure tube reactor (6-12 Mpa). The reaction is exothermic and
often run under adiabatic conditions with reactor temperatures in the
range of 250-400 deg C. The resulting product mixture is decompressed
and distilled. The NMP yield is normally more than 97 percent .
100 million to 500 million pounds/yr (2002)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
From trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X 1
x 2
x 2
x 1
1
2
4
3
US
in scope
2002
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
High

1.6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
2016. Agent name: N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3860491
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	Used as resin in microelectronics industriesl paint stripping; lube oil
extraction; pesticides; coatings; adhesivesl dyes; pigments; polymers;
polyurethane foam cleanup
Process Description:	Lists the life cycle stages and chemical - physical properties.
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
NIH information
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
in scope
Metric 4:
Temporal Representativeness
High
X
2
2
2016
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
underlying methods, data sources, and assumptions are not






fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	N/A	N/A This metric is not applicable to this data type
Overall Quality Determination1	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
514

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860493
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Petrochemical
Acetylene recovery from cracked gas, extraction of aromatics and buta-
diene, gas purification (removal of C02 and H2S)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
oldest source listed from 1999
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
515

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860493
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Processing
plastics
Reaction medium for the production of high-temperature polymers such
as polyethersulfones, polyamideimides, and polyaramids
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
oldest source listed from 1999
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
516

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860493
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Electronics
Cleaning agent for silicon wafers, photoresist stripper, auxiliary in
printed circuit board technology
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
oldest source listed from 1999
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
517

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860493
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Manufacture
Manufacture
Large-scale production of NMP is predominantly carried out by reacting
gamma-butyrolacetone with an excess of pure or aqueous methyamine in
a high-pressure tube reactor (6-12 Mpa). The reaction is exothermic and
often run under adiabatic conditions with reactor temperatures in the
range of 250-400 deg C. The resulting product mixture is decompressed
and distilled. The NMP yield is normally more than 97 percent . It can
also be produced by hydrogenation of N-hydroxymethyl-2-pyrrolidone or
reaction of acrylonitrile with methylamine in the presence of a peroxide
radical initiator.
12
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
oldest source listed from 1999
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
High

1.5

Continued on next page
518

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
2017. Hazardous substances data bank: l-Methyl-2-pyrrolidinone.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3860493

EVALUATION
Domain
Metric Rating MWF* Score
Comments


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
519

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Australian Government Department of, Health. 2016. Human health tier III assessment for l-methyl-2-pyrrolidinone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3969286
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
All
coating (paints, writing inks); cleaning products (paint strippers, glue
and grease removers, sealant removers); cosmetic and personal care prod-
ucts
Source is a high-level risk assessment for potential consumer exposure
to NMP in consumer products.
100 to 1000 tonnes (Australia)
5 percent (consumer prod limit in Europe); 0.3 percent (proposed new
consumer prod limit)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
High quality - journal articles, etc
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
Low
x 2
6
non-occupational scenario that is similar to an occupational





scenario
Metric 4:
Temporal Representativeness
High
x 2
2
2016
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
Medium
1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
520

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2017. Inert details: N-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3970073
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	pesticides
Process Description:	40 CFR 180.920 - indicates NMP is used in pesticides as a Solvent,
cosolvent
EVALUATION
Domain
Metric
Rating
MWF*
Score

Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
CFR


Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
2004
This metric
is not applicable to this
data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
This metric
is not applicable to this
data type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric
is not applicable to this
data type
Overall Quality Determination^
High

1.3



* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
521

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Echa,. 2017. Substance information: l-Methyl-2-pyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3970774
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
All
pH regulators and water treatment products andlaboratory chemicals.
Substance information, including physical-chemical properties
This substance is manufactured and/or imported in the European Eco-
nomic Area in 10,000 to 100, 000 tonnes per year.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
ECHA substance database
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Medium
High
N/A
X 1
x 2
x 2
2
4
2
N/A
Europe
some of these uses were not identified by EPA
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Medium

1.7

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Echa,. 2017. Uses as industrial sites: l-Methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Flero ID
3970775
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	Processing as intermediate; Formulation; Spray Application; Roll ap-
plication; Brush application; Dip /pour; Lab; tabletting, compression,
extrusion, pelletisation; Functional fluid; Lubrication at high energy con-
ditions; cleaning
Process Description:	List of life cycle stages and worker activites (high-level, such as transfer
or spraying)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Lligh
x 1
1
ECHA substance database
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
Lligh
High
N/A
X 1
x 2
x 2
2
2
2
N/A
Europe
all in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
523

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Echa,. 2017. Uses by professional workers: l-Methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3970776
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	All (see above row)
Process Description:	Same information as 3970775
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
ECHA substance database
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
Europe
all in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
524

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Echa,. 2017. Consumer uses: l-Methyl-2-pyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3970777
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Consumer Use
Printing
Indicates NMP is used in inks and toners by consumers
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
ECHA substance database
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
Europe
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High
1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
525

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Niosh,. 2014. Health hazard evaluation report no. HHE-2011-0099-3211, evaluation of employee exposures during sea lamprey
pesticide application.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3974909
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Use
Agricultural products
Process Description:
Operating Days per Year and Batches per Day:
Possible Physical Form:
Chemical Concentration:
Employees manually applied pesticides into rivers to control sea lamprey
larvae. Bayluscide wettable powder and emulsifiable concentrate are
used. Technicians prepare equipment, then transport, mix, and apply
pesticides into the river. Technicians also analyze river water samples
in portable laboratories to measure pesticide concentrations throughout
a treatment period. Mix Bayluscide wettable powder into water before
pumping it into a maintenance application site
38 employees
wettable powder and emulsifiable concentrate
The liquid Bayluscide concentrate contains N-methyl-2-pyrrolidone
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information is from trusted sources (NIOSH HHE)
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
Agriculutral use is in scope
2014
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
The report addresses variability and uncertainty in the results.
Continued on next page
526

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Niosh,. 2014. Health hazard evaluation report no. HHE-2011-0099-3211, evaluation of employee exposures during sea lamprey
pesticide application.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3974909
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

High 1.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
527

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Argonne National, Laboratory. 2015. Lithium-ion battery production and recycling materials issues.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3974981
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Batteries
NMP is used as a binder solvent in the assembly of lithium-ion batter-
ies. (I think binders are used to adhere the electrolytic cells to to the
battery).
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
not from trusted sources, but do not seem flawed
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
in scope
2015
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Assessment or report provides results, but the underlying
methods, data sources, and assumptions are not fully trans-
parent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
528

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Nicnas,. 1997. Full public report: Polymer in byk-410.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3978356
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Processing
polymer
NMP is the solvent in which the polymer is dispersed. The NMP-
polymer solution is added to coatings and serves to affect the rheological
properties of the coating
2,750 kg of NMP-polymer soln imported to Australia for use
45 percent NMP; 55 percent polymer
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Information from industry contact. Not standard trusted
source but no flaws identified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Low
Low
X 1
x 2
x 2
x 1
2
2
6
3
Australia
in scope
1997
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
sources are not fully transparent, due to confidentiality of in-
dustry contact
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

2.2

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Nicnas,. 1997. Full public report: Polymer in byk-410.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978356
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Processing
coating /paint formulation
The mentioned NMP-polymer soln is added to coatings such that it
(NMP is 45 percent in NMP-polymer disp) is added to coatings at a
concentration of 0.1-3wt percent (corresponds to 0.45 to 1.35 percent
NMP)
2,750 kg of NMP-polymer soln imported to Australia for use
0.45 to 1.35 percent NMP in coating/paint
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Information from industry contact. Not standard trusted
source but no flaws identified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Low
Low
X 1
x 2
x 2
x 1
2
2
6
3
Australia
in scope
1997
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
sources are not fully transparent, due to confidentiality of in-
dustry contact
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

2.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
530

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Formulation
polymeric adhesive for leather coating application
Adhesive will be decanted or pumped into a stainless steel mixing vessel,
mixed with other components such as pigment, defoamer, thickener and
water. Formulation is gravity fed or pumped into 200 litre drums or 20
litre pails and transported to the spray line (or customers).
Up to 40 tonnes/yr of polymer in formulation (polymer is 35 percent ;
NMP os 5 percent )
5 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information is from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
Low
X 1
x 2
x 2
x 1
2
2
4
3
Australia
Adhesive formulation is in scope
2001
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
531

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 2001. Full public report: Polymer in primal binder u-51.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3978357
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
polymeric adhesive for leather coating application
Formulation is pumped directly from drums or pails to spray unit. The
formulation will be applied by rotary spray application to untreated
leather on a conveyor line, and the treated leather will then be dried in
ovens through a drying tunnel prior to further treatment. Any overspray
is filtered and caught in a water curtain filtering system during the spray
application.
Up to 40 tonnes/yr of polymer in formulation (polymer is 35 percent ;
NMP os 5 percent )
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Information is from trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
Low
X 1
x 2
x 2
x 1
2
2
4
3
Australia
Adhesive use is in scope
2001
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
532

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3978358
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Operating Days per Year and Batches per Day:
Chemical Concentration:
Use
Coating /additive in Papermaking
Polymer in NMP is imported to Australia in 50 kg to 1 tonne containers
for use in the paper and building industries. Polymer may be used as a
surface or internal treatment for paper and paper type products. The
product containing the notified polymer is transferred to a mixing tank,
which may have a holding capacity of up to 1,000 L. Product will then
be diluted significantly with water and applied to paper using rollers and
spray equipment. As internal paper treatment, the notifier states that
the product containing the notified polymer will be added to the paper
pulp following the washing and bleaching process, but before rolling and
cutting of the final paper product.
2500 kg polymer-NMP soln imported to Australia for use; assumed 2,000
kg/yr for paper
1 (assumed)
300 days/yr (assumed)
30 percent polymer & 10 to < 30 percent NMP in soln that is diluted
prior to use at paper mill
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Information from industry contact. Not standard trusted





source but no flaws identified.
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Australia
Metric 3:
Applicability
High
x 2
2
This was not identified as a use by EPA, but no uses are ex-





cluded from scope. May be applicable to coating OES?
Metric 4:
Temporal Representativeness
Low
x 2
6
1998
Metric 5:
Sample Size
Low
x 1
3
Characterized by no statistics
Continued on next page
533

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Facility; Reports for Data or Information Other than Exposure
3978358
or Release Data;
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X 1
2
sources are not fully transparent, due to confidentiality of in-
dustry contact
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1
3
No discussion
Overall Quality Determination^
Medium

2.2


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
534

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Nicnas,. 1998. Full public report: Copolymer in foraperle 321.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3978358
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Use
architectural (concrete) coating
product containing the notified polymer usually will be applied by brush
hence dermal and accidental ocular exposure may occur. The polymer
is used at 2.5 g.m-2.
2500 kg polymer-NMP soln imported to Australia for use; Assumed 500
kg/yr for coating
5 to 10 percent solution containig polymer & NMP in coating
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Information from industry contact. Not standard trusted
source but no flaws identified.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Low
Low
X 1
x 2
x 2
x 1
2
2
6
3
Australia
in scope
1998
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
sources are not fully transparent, due to confidentiality of in-
dustry contact
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
No discussion
Overall Quality Determination^
Medium

2.2

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Osha,. 2006. OSHA permissible exposure limit and general information: n-methyl-2-pyrrolidinone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981001
EXTRACTION

Parameter
Data
Life Cycle Stage:	All
Life Cycle Description (Subcategory of Use):	All
Process Description:	Physical chemical properties; health effects; lab sampling method
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
OSHA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
High
N/A
X 1
x 2
x 2
1
4
2
N/A
US
Information is not related to a life cycle stage, but is broadly
applicable
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.4

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
536

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: N-Methylpyrrolidone Procedures Group, Inc. 2006. N-methyl 2-pyrrolidone (NMP) considerations against use in cosmetics,
toiletries, and personal care products.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3981020
EXTRACTION
Parameter Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Pharmaceutical
Process Description: NMP was used in cosmetics, toiletries, and personal care products. The
EU banned this use and prohibited the general public from using non-
cosmetic products containing >=5 percent NMP.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X 1
3
The data, data sources, and/or techniques used in the assess-

ment or report are not specified.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Unacceptable
x 2
8
Pharmaceutical use is a non-TSCA use. Reported use is cos-

metics; therefore, out of scope.
Metric 4:
Temporal Representativeness
Medium
x 2
4
2006
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Low X 1 3 data sources, and assumptions are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
no discussion
Overall Quality Determination^
Unacceptable
4
Metric Mean Score: 2.8.

** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
537

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981028
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	manufacturing
Process Description:	produces high-purity, high-grade NMP from maleic anhydride in an in-
tegrated productionprocess.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
538

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3981028
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Metal finishing; Electronics
Electronics: Wax, flux removal. Burr removal. Electronic parts clean-
ing. Semiconductor parts cleaning. Solvent for lithium battery manu-
facturing. Semiconductor photo-resist thinner. Color filter photo-resist
thinner
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
539

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981028
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Automotive care
Process Description:	Mold cleaning.Metal (parts) cleaning.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
540

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981028
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	Petrochemical
Process Description:	Extract agent (acetylene, BTX, butadiene).
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
541

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981028
EXTRACTION

Parameter
Data
Life Cycle Stage:	Processing
Life Cycle Description (Subcategory of Use):	intermediate
Process Description:	Reaction solvents (PPS, polyimide, etc.)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
542

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Mitsubishi, Chemical. 2017. NMP/N-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981028
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	cleaning
Process Description:	Plastic lens manufacturing equipment cleaning. Equipment washing.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
NMP MFG site is in Japan
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^	High	1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
543

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Johnson Matthey Process, Technologies. 2017. N-methyl-2-pyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3981029
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Manufacture
Manufacturing
Contains PFD and reaction sequences. Our technology generates high-
quality NMP by reacting gamma-butyrolactone (GBL) and monomethy-
lamine (MMA), which are products of our butanediol and methylamines
processes, respectively. Additional process description available.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
N/A
X 1
x 2
x 2
3
2
2
N/A
Unknown - could be US based or other countries
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Data sources not transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
544

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Bpi,. 2017. NMP free water borne polyurethane dispersions.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981030
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Coatings
Process Description: N-Methyl-2-Pyrrolidone (NMP) is the most common co-solvent used in
the manufacture of waterborne polyurethane dispersions. The unique
properties of NMP aid in both the processing of the polyurethane dis-
persions as well as the flm formation of the applied polyurethane coating.
In addition, the NMP can help with substrate wetting, freeze/thaw sta-
bility, and adhesion to some substrates.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X
1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
N/A
XXX
1
2
2
3
2
2
N/A
Unknown - could be US based or other countries
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^ Medium 1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
545

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Spin,. 2017. SPIN substances in preparations in nordic countriesl-methyl-2-pyrrolidon.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3981132
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
All
All
Lists applicable Nordic NAICS equivalants. List of uses in nordic coun-
tries, in generic terms (i.e., degreasers, paints, laquers and varnishes,
etc.).
lists nordic PV for each use
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Nordic substance database
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
Norway, Finland, other OECD member countries
in scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High
1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
546

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
European Chemicals, Agency. 2016. l-methyl-2-pyrrolidone brief profile.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3981148
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	Manufacture or import
Total Annual U.S. Volume (and percent of PV):	10,000-100,000 tonnes/yr (EU)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
not from trusted sources, but do not seem flawed
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Low
High
High
Low
X 1
x 2
x 2
x 1
3
2
2
3
Europe
in scope
2016
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Assessment or report provides results, but the underlying
methods, data sources, and assumptions are not fully trans-
parent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Medium

2.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
547

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Basf,. 1990. Technical information: N-methylpyrrolidone handling and storage.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982070
EXTRACTION

Parameter
Data
Life Cycle Stage: All
Life Cycle Description (Subcategory of Use): All
Process Description: Physical chemical properties; lab analysis methods; biodegradability and
aquatic toxicity; lists proper storage and equipment that should be used
for NMP. NMP can be handled in carbon steel, stainless steel or nickel
equipment. Aluminum is suitable for NMP service at ambient tempera-
tures, only. Storage at ambient temperatures will not affect NMP. Cool
storage conditions and light paint on aboveground tanks decrease evap-
orative losses.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
Medium
Low
N/A
X 1
x 2
x 2
1
4
6
N/A
US
Information is not related to a life cycle stage, but is broadly
applicable
1990
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Turi,. 1996. N-methyl pyrrolidone: Chemical profile.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982071
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Manufacture
Manufacturing
NMP is manufactmd mainly by condensing butyrolactone with methy-
lamine. It may also be made by high pressure synthesis from acety-
lene and formaldehyde. Separation of the water and NMP is generally
achieved by distillation,
at least 99.8
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
data or techniques that are high quality
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
in scope
1996
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
High
1.6
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
549

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Turi,. 1996. N-methyl pyrrolidone: Chemical profile.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982071
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Paint stripper
paint stripping accounts for only 10-15 percent
10-15 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
data or techniques that are high quality
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
in scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1996
Metric 5:
Sample Size
Low
x 1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Medium
x 1
2
limited discussion
Overall Quality Determination^
Medium
1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
550

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 1998. Cleaner technologies substitutes assessment for professional fabricare processes: Appendix F: Chemical
volume estimates: Screen printing CTSA.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982072
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Batch Size:
Operating Days per Year and Batches per Day:
Site Daily Throughput:
Possible Physical Form:
Chemical Concentration:
Use
screen printing - cleaning of screens
38,000 gal NMP used in screen cleaning/yr
20,000 screen printing facilities
screen size and additional parameters to determine chemical cleaning
throughput in Table F-l
assumed 252 days/yr
57 percent of facilities clean one to ten screens, or an average of 5.5 a
day.
liquid
35 percent NMP in solution used to clean screens
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
USEPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
Low
X 1
x 2
x 2
x 1
1
2
6
3
US
in scope
1998
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
report clearly documents its data sources, assessment methods,
results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
limited discussion
Continued on next page
551

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	U.S, E. P. A.. 1998. Cleaner technologies substitutes assessment for professional fabricare processes: Appendix F: Chemical
volume estimates: Screen printing CTSA.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982072
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

Medium 1.8


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
552

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
University of, Minnesota. 2007. Safter stripping and cleaning chemicals for coatings & polymers.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982073
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Paint stripper
Process Description:	alternative stripping methods include: abrasive blasting, water blasting,
scraping, sanding, tumbling, burnoffand cold shock
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
not from trusted sources; however, associated information does
not indicate flaws or quality issues
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
2007
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
553

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982074
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Batch Size:
Possible Physical Form:
Use
immersion degreasing
Degreasing with NMP entails the immersing of an oil coated metal part
into a heated bath of NMP, where the oil is solubilized. Upon removal
from the cleaning bath, the part is immersed into a second heated bath,
to remove the oil contaminated NMP from the metal surface. The sec-
ond, or rinse bath, can be filled with either NMP or water.Drying the
rinse liquid from the metal part is required.
10 complete cleaning cycles/hr; 5.0 lbs of parts cleaned per cycle
liquid
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Medium X 1	2 not from trusted sources, but do not seem flawed
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Cleaning is included in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1993
Metric 5:
Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low x
1
3
Assessment or report provides results, but the underlying
methods, data sources, and assumptions are not fully trans-
parent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x
1
3
no discussion
Overall Quality Determination^
Medium

2.2


Continued on next
page


554

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Basf,. 1993. Modification of a vapor degreasing machine for immersion cleaning use N-methylpyrrolidone.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982074
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
555

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Erg,. 2000. Preferred and alternative methods for estimating air emissions from paint and ink manufacturing facilities.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3982076
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Processing
Paint and ink formulation
Paint and ink manufacturing can be classified as a batch process and gen-
erally involves the blending/mixing of resins, pigments, solvents, and ad-
ditives. Traditional paint and ink manufacturing consists of four major
steps: Preassembly and premix; Pigment grinding /milling /dispersing;
Product finishing/blending; and Product filling/packaging (Fisher et al.,
1993).
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Prom trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
in scope
2000
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
556

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Larranaga, M. D.,Lewis, R. J.,Lewis, R. A.. 2016. Hawley's Condensed Chemical DictionaryN-methyl-2-pyrrolidone.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982124
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): Solvent for resins, acetylene, etc., pigment dispersant, petroleum pro-
cessing, spinning agent for polyvinyl chloride, microelectronics industry
plastic solvent applications, intermediate.
Process Description: lists physical chemical properties and uses of NMP
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Hawley's Condensed Chemical Dictionary
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
XXX
1
2
2
1
2
2
N/A
US
all uses are in scope
2016
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
underlying data source are not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^ High 1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
557

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Technikon, L. L. C.. 2001. Core box cleaner study: Evaporative emission study of specialty systems' solvent FC-47-G1.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3982183
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Batch Size:
Chemical Concentration:
Use
cleaning of casts /molds and hoppers in foundry applications
Cleaning to remove sand from casting and molding equipment. Solvent
is sprayed onto casts /molds at 80-90 psi, rate of 0.08-0.27 gal/min.
Solvent allowed to soak for 20 mins, then removed when the next part
is molded and removed. Solvent sprayed on hoppers, soaked for 2-13
hours, chipped off.
Molds = 0.5-1.2 gal of solvent /mold /day; Hoppers = 4.0-5.4 gal/
hopper/day
NMP at unknown concentration
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
High quality techniques
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Medium
X 1
x 2
x 2
x 1
1
2
4
2
US
in scope
2001
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
well characterized
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
558

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Oehha,. 2007. Occupational health hazard risk assessment project for California: Identification of chemicals of concern,

possible risk assessment methods, and examples of health protective occupational air concentrations.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982225
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	Manufacturing
Total Annual U.S. Volume (and percent of PV):	>100M-500M
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
data or techniques that are high quality
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X 1
x 2
x 2
x 1
1
2
4
3
US
in scope
2002
Characterized by no statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
clearly documents its data sources
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
addresses variability and uncertainty
Overall Quality Determination^
High

1.4


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
559

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ec,. 2004. Effectiveness of vapour retardants in reducing risks to human heafth from paint strippers containing
dichloromethane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982358
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Paint stripper
Chemical Concentration:	5-20 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
trusted sources
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Medium
Medium
X 1
x 2
x 2
x 1
2
2
4
2
Belgium
in scope
2004
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data sources are generally described but not fully transparent.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
no discussion
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
560

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Erm,. 2017. Life cycle assessment of used oil management.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3982372
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Batch Size:
Use
Petrochemical
NMP can be used for re-refining of used oil to produce lube base oil.
Some porcess information on pg 70, but confidentiality claims make it
difficult to know the process used.
0.06 kg NMP/1 kg of processed used oil
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Medium x 1
The assessment or report uses high quality data and/or tech-
niques that are not from trusted sources; however, Associated
information does not indicate flaws or quality issues.
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US
Metric 3: Applicability
High
X
2
2
in scope
Metric 4: Temporal Representativeness
High
X
2
2
2017
Metric 5: Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
Low
X
1
3
Assessment or report provides results, but the underlying

methods, data sources, and assumptions are not fully trans-

parent.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
High
X
1
1
well characterized
Overall Quality Determination^
High

1.6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: U.S, E. P. A.. 2013. Fact sheet: N-Methylpyrrolidone (NMP).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986610
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Paint and Coating Removal
Indicates that Gloves made of butyl rubber or laminated polyethylene/
EVOH are resistant to NMP. Does not list customary PPE.
9 percent of 184 million lbs/yr
EVALUATION

Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability

Metric 1:
Methodology
Low
X 1 3 The data, data sources, and/or techniques used in the assess-

ment or report are not specified.
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
Low
X
2
6
No date
Metric 5: Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
Unacceptable
X
1
4
Assessment or report does not document its data sources, as-

sessment methods, and assumptions.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Unacceptable

4
Metric Mean Score: 2.4.
** Consistent with our Application of Systematic Review in TSCARisk Evaluations document, if a metric for a data source receives a score of Unacceptable (score = 4),
EPA will determine the study to be unacceptable. In this case, one of the metrics were rated as unacceptable. As such, the study is considered unacceptable and the
score is presented solely to increase transparency.
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
562

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	McCormick, L. 2017. Comment submitted by Lindsay McCormick, Chemicals and Health Project Manager on behalf of
Environmental Defense Fund (EDF). EDF.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3986675
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Chemical Concentration:
Use
coating
<5 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
563

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	paint stripper /removers
Chemical Concentration:	25-50 percent ; 10-15 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
McCormick, L. 2017. Comment submitted by Lindsay McCormick, Chemicals and Health Project Manager on behalf of
Environmental Defense Fund (EDF). EDF.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986675
564

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Holmes, L. 2017. Comment submitted by Laurie Holmes, Senior Director, Environmental Policy, Motor & Equipment Manu-
facturers Association (MEMA). Motor & Equipment Manufacturers Association.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986676
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Adhesive
NMP is used during the motor vehicle component manufacturing process
as an adhesive (added as a viscosity aid). It may also be used in inks,
varnishes, paint thinners, paint primers, paint removers, paste, lacquer,
and solvents. When NMP is used as a viscosity aid in an adhesive in
automotive applications, the chemical is cured and there is no solvent
remaining.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High
1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
565

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Thomas, T. 2017. Comment submitted by Todd Thomas, ELANTAS PDG, Inc. (EPDG).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3986789
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Processing /Use
Polymers and Electronics (wires)
Functional Uses: Reaction medium for the manufacture of high tem-
perature polymers; Solvent and/or diluent for synthesis of wire enamels
and related intermediates; Dye solutions for use in wire coatings; Pro-
cess vessel cleaning solvent; Limited use as an industrial cleaning solvent
strictly in the wire coating industry; Limited use as a cleaning solvent in
regulated metal parts washer applications; Limited use as a flexibilizer
for B-Stage coatings (i.e. dried but not cured)
EPDG used the following weights (in pounds) by year going back to
2014:- 2014 1,606,040- 2015 1,481,993- 2016 1,253,048
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.1

Continued on next page
566

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Thomas, T. 2017. Comment submitted by Todd Thomas, ELANTAS PDG, Inc. (EPDG).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3986789
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
567

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Brown, T; Bennett, S. 2017. Comment submitted by Timothy Brown, Regulatory Counsel and Steven Bennett, Vice President

of Scientific Affairs, Consumer Specialty Products Association (CSPA). Consumer Specialty Products Association.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986792
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): metal finishing
Process Description: CSPA notes industrial/commercial use of N-methylpyrrilidone as pene-
trant used for determination of metal fatigue for turbines, bridges, and
other critical uses, for inspections of metal fatigue, welding cracks, etc.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^ High 1.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
568

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: MacRoy, P. 2017. Comment submitted by Patrick MacRoy on behalf of Environmental Health Strategy Center et al.. Envi-
ronmental Health Strategy Center.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986795
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacture / import
The CDR submissions data for 2011 through 2015, inclusive, report an
average annual U.S. production (domestic manufacture plus imports)
of 170 millions pounds per year, with a range from 160 to 187 million
pounds. During this same time period, imports from China rose sharply
to four million pounds, more than 2 percent of total U.S. production,
four companies producing NMP in the United States according to CDR
and other data: Ashland (in Texas City, TX), BASF (Geismar, LA),
Eastman (Fieldale, VA), Lyondell (Channelview, TX)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.1

Continued on next page
569

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
MacRoy, P. 2017. Comment submitted by Patrick MacRoy on behalf of Environmental Health Strategy Center et al.. Envi-
ronmental Health Strategy Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986795
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
570

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	paints, coatings, adhesives
Chemical Concentration:	5-7 percent ; 0.25-0.5 percent ; <4 percent ; 8-12 percent ; 1-2.5 percent ;
0.3-1 percent ; 5-10 percent ; 1.6 percent ; 2.5-10 percent ; 1-2.5 percent ;
1-2.5 percent ; 0.1-1 percent ; 0.1-1 percent ; 0.1-1 percent ; 0.1-1 percent
; 1-3 percent ; 1-2.5 percent ; 2.5-10 percent ; 1-3 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
MacRoy, P. 2017. Comment submitted by Patrick MacRoy on behalf of Environmental Health Strategy Center et al.. Envi-
ronmental Health Strategy Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986795
571

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with

respect to this infomration.
Domain 2: Representative

Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
Medium
x 2
4
Pesticide not in scope of TSCA; however, information is appli-

cable to formulation
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5: Sample Size
Medium x 1
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2 Limited information on concentration variability
Overall Quality Determination^
High
1.6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	cleaners
Chemical Concentration:	100 percent ; 100 percent ; 5-10 percent ; <1 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
MacRoy, P. 2017. Comment submitted by Patrick MacRoy on behalf of Environmental Health Strategy Center et al.. Envi-
ronmental Health Strategy Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986795
573

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	paint stripper /removers
Chemical Concentration:	50 percent ; 10-20 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From environmental organization. No bias /errors evident with
respect to this infomration.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
MacRoy, P. 2017. Comment submitted by Patrick MacRoy on behalf of Environmental Health Strategy Center et al.. Envi-
ronmental Health Strategy Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986795
574

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,

NMP Producers Group, Inc.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986796
EXTRACTION

Parameter
Data
Life Cycle Stage: Use
Life Cycle Description (Subcategory of Use): electronics - Photoresist Stripping
Process Description: NMP is used as a solvent in circuit board manufacturing in photoresist
stripping. Some facilities report that photoresist stripping occurs in
batches; others report continuous processing. The NMP used in the
process is up to 100 percent concentration, is in liquid or liquid spray
form, and is heated up to 85 "F. Facilities report that storage can be in
55-gallon drums, totes, or one to five gallon bottles.
Chemical Concentration: up to 100 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^ High 1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
575

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986796
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
electronics - Soldermask Stripping
Liquid NMP (up to 99.9 percent concentration) is used to remove solder
mask in circuit boards. Solder mask stripping typically occurs as a
batched process in an open topped tank equipped with ventilation. The
NMP used is reportedly at ambient temperature or heated up to 180"F.
The NMP used in the process is typically stored in 55-gallon drums or
one to five gallon containers,
up to 99.9 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High

1.3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986796
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Processing
Chemical processing, excluding formulation (polymer manufacturing)
NMP is a carrier solvent used to uniformly apply a polymer to man-
ufacture an industrial membrane. The polymer and NMP are mixed
as batches in a steel tank with controlled releases and local ventilation,
followed by application of the polymer solution and extraction of the
NMP in a water bath. The NMP used in the process is greater than 50
percent concentration in liquid form and is heated. NMP can be stored
in tanks, bulk containers, totes, or drums,
greater than 50 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High

1.3

Continued on next page
577

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986796
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
578

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986796
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Fertilizer application
NMP is a solvent used in the production of a fertilizer additive that
prevents the volatilization of urea (as ammonia). As further detailed
below, fertilizer additive products that may contain NMP are controlled
and finished fertilizers that have such small amounts of NMP, it would be
an unnecessary expenditure of EPA"s time to evaluate them for further
regulatory restriction.
15-45 percent in additive; 0.1 percent in final product
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
579

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986796
EXTRACTION
Parameter Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Processing
Formulation and distribution
NMP is often handled by distributors that blend and package products
containing NMP, such as industrial paint stripper formulations or indus-
trial surface cleaning blends. On site, NMP is stored in tanks, totes,
drums, or tank trucks. Within the distribution facility, NMP is pro-
cessed in mixers and tanks within closed and controlled release systems.
Processing is typically batched. The NMP is in the liquid form at am-
bient or increased temperature.
5-100 percent
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology Medium X 1 2 From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High x 1 1 US
High X 2 2 In scope
High x 2 2 2017
Medium X 1 2 Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High x 1
1 Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2 Limited information on concentration variability
Overall Quality Determination^
High
1.3
Continued on next page
580

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Roberts, KM. 2017. Comment submitted by Kathleen M. Roberts, N-Methylpyrrolidone (NMP) Producers Group Manager,
NMP Producers Group, Inc.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986796
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
581

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Paints, coatings, adhesives
Chemical Concentration:	0.5 percent ; 5-15 percent ; <5 percent ; <1.5 percent ; <0.5 percent ;
<14 percent ; <1 percent ; 1-5 percent ; <0.5 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
Gerber, JM. 2017. Comment submitted by Jonathan M. Gerber, Advanced Regulatory Specialist, 3M Medical Department,
Toxicology & Compliance Solutions 3M Center, Part 2. 3M Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986797
582

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Printing Inks
Chemical Concentration:	5-10 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
Gerber, JM. 2017. Comment submitted by Jonathan M. Gerber, Advanced Regulatory Specialist, 3M Medical Department,
Toxicology & Compliance Solutions 3M Center, Part 2. 3M Center.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986797
583

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Riegle, L. 2017. Comment submitted by Leslie Riegle, Director of Environmental Policy Aerospace Industries Association
(AIA), Part 3. Aerospace Industries Association.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986798
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Paint stripper
Specific aerospace industrial uses include but may not be limited to:
solvents for both cleaning and removal of coatings (in electronics as
well as for use with specific coatings and applications); as a constituent
in adhesives, release agents, inks, coatings (including topcoats, primers
and specialty coatings) surface pretreatments; as well as a sealant for
sensitive military aircraft applications.
15-35 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
584

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Anonymous. 2017. Anonymous public comment, Part 7.
Type of Data Source Facility; Reports for Data or
Hero ID 3986799
Information Other than Exposure or Release Data;
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Processing
Chemical processing, excluding formulation (polymer manufacturing)
NMP is imported as a dispersant liquid for polymer particles. NMP
solution is applied by gravure to form a polymer film. NMP is dried and
captured for recycle/reuse.
<1 metric ton; max. of <20 metric ton/yr
6 companies in the US that use NMP this way
EVALUATION
Domain Metric Rating MWF* Score Comments
Domain 1: Reliability
Metric 1: Methodology
Low X 1 3 Anonymous comment - data, data sources, and/or techniques
used in the assessment or report are not specified
Domain 2: Representative

Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
In scope
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
Information is from the source
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Davis, R. 2017. Comment submitted by Raleigh Davis, Assistant Director, Environmental Health and Safety, American
Coatings Association (ACA), Part 2. American Coatings Association.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986800
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Paints, coatings, adhesives
NMP is used as a coalescing aid in antistatic applications. NMP is
used in wax dispersions technology, allowing coatings systems to im-
prove thedispersions of pigments. NMP is used as a rheology additive to
control the viscosity of urethane coatings in the processof making aque-
ous dispersions. NMP is capable of dissolving polymers that are difficult
to process.
0.5 percent ; <1 percent ; 5-15 percent ; 1-5 percent ; 0.1-1 percent ;
<0.1 percent ; 1-5 percent ; 45-60 percent ; 5-10 percent ; 1-5 percent ;
0.1-1 percent ; <2 percent ; <1.5 percent ; <0.2 percent ; 10-50 percent
; 1-5 percent ; 0.1-1 percent ; 1-5 percent ; <5 percent ; <1.5 percent ;
<0.5 percent ; <14 percent ; 1-2 percent ; 0.8-2.1 percent ; 2-3 percent
; 0.2-2 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
Trade association poll of manufacturers. No bias /errors evi-





dent.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
In scope
Metric 4:
Temporal Representativeness
High
x 2
2
2017
Metric 5:
Sample Size
Medium
x 1
2
Range with uncertain statistics
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Continued on next page
586

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Metric 7: Metadata Completeness	Medium X 1	2 Limited information on concentration variability
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
Davis, R. 2017. Comment submitted by Raleigh Davis, Assistant Director, Environmental Health and Safety, American
Coatings Association (ACA), Part 2. American Coatings Association.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986800
587

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Isaacs, D. 2017. Comment submitted by David Isaacs, Semiconductor Industry Association (SIA).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986801
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Electronics - semiconductor manufacturing
The semiconductor industry uses NMP in manufacturing for three main
purposes:l. Dedicated solvent in certain photolithography formulations,
including photoresists, Bottom Anti-Reflective Coatings (BARC) and
polyimides2. Solvent pre-wet of wafers prior to application of spin on
polymer3. Component of photoresist stripper formulations.
No NMP is present in the final polyimide film.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Trade association poll of manufacturers. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Rudnick, M. 2017. Comment submitted by Michelle Rudnick, Senior Manager Regulatory Affairs, CRC Industries, Inc., Part
2. CRC.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986802
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Batch Size:
Chemical Concentration:
Use
paint stripper /removers
CRC uses NMP in two gasket remover aerosol products and one graffiti
remover aerosol product. To use the product, we recommend that the
surface be coated with the graffiti remover product and allowed to sit
for 5 minutes. The paint can then be wiped or scraped off.
3 oz (1/4 of a can) for the average gasket
<=20 percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High

1.3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: National Electrical Manufacturers Association. 2017. Comment submitted by National Electrical Manufacturers Association
(NEMA).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986803
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Electronics - magnet wires
The magnet wire industry has long utilized NMP as a solvent/diluent in
high-performance magnet wire enamels, thinners, and cleaners. Specifi-
cally, magnet wire plays a critical role in three areas of energy transfor-
mation through its use today in transformers, motors and generators. In
the magnet wire industrial process a copper or aluminum wire is routed
through an applicator of solvent-based enamel coating. NMP does not
react with the other ingredients in this coating, but is simply mixed in
to facilitate the smooth application of the enamel.
80-85 percent
EVALUATION

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	National Electrical Manufacturers Association. 2017. Comment submitted by National Electrical Manufacturers Association
(NEMA).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3986803
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
591

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Haas, G. 2017. Comment submitted by Gerhard Haas, Vice President, Research & Development, Technical Service, Purchasing,
Jowat Corporation, Part 2. Jowat Corporation.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3986804
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Use
coating
Primer which promotes adhesion. The NMP containing primer is applied
with a slot die and then dried in a heat tunnel.
imported 850001bs of the primer last year which contained a total of
4250 lbs of NMP
<5 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
592

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Turner, S. L.,McCrillis, R. C.. 2017. Evaluation of alternative chemical strippers on wood furniture coatings.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3986887
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Batch Size:
Chemical Concentration:
Use
Paint stripper
Solvent strippers work solely by dissolving the coating film. Their dis-
solving mechanism causes themto become rapidly saturated with dis-
solved coating.
1.74 to 3.23E-04 m3 of stripper per m2 of substrate surface
50-75 percent
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Medium x 1
The assessment or report uses high quality data and/or tech-
niques that are not from trusted sources; however, Associated
information does not indicate flaws or quality issues.
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US
Metric 3: Applicability
High
X
2
2
In scope
Metric 4: Temporal Representativeness
Low
X
2
6
No date
Metric 5: Sample Size
Low
X
1
3
Characterized by no statistics
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
Low
X
1
3
Assessment or report provides results, but the underlying

methods, data sources, and assumptions are not fully trans-

parent.
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
Low
X
1
3
The report does not address variability or uncertainty.
Overall Quality Determination^
Medium

2.2

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1988. PRODUCTION EXPOSURE PROFILE N-METHYLPYRROLIDONE.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214097
EXTRACTION
Parameter
Data



Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Domestic manufacturing
BASF productioin in 1987 estimate of 15-25 million lbs/yr, no known
volume for second producer, no imports
2
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
Manufacturing in scope
1988
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
High

1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
594

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Us, E. P. A.. 1988. PRODUCTION EXPOSURE PROFILE N-METHYLPYRROLIDONE.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	4214097
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Chemical Concentration:
Processing
Formulation
Processing NMP into paint stripper formulations.
6
<=49
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
Manufacturing in scope
1988
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data sources are included
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
595

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: E. I. Dupont De Nemours,Co,. 1990. LETTER FROM E I DUPONT DE NEMOURS & COMPANY TO USEPA SUBMIT-
TING COMMENTS CONCERNING THE PROPOSED TEST RULE ON N-METHYLPYRROLIDONE WITH ATTACH-
MENT.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 4214100
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Site Daily Throughput:
Processing
Processing as a reactant
Several industrial applications including dissolving organic polymers and
monomers for manufacture of synthetic fibers, resings, composite mate-
rials and film coatings.
55 million lbs/yr in 1989
1
Daily use unknownAnnual use of 1.6 million lbs/yr in 1989
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
X 1
x 2
x 2
1
2
6
N/A
US
Processing in scope
1989
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data is from source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination^
Medium

1.7

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability

Metric 1:
Methodology
High
X
1
1
EPA
Domain 2: Representative

Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Manufacturing in scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1989
Metric 5:
Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6:
Metadata Completeness
High
X
1
1
Data sources included
Domain 4: Variability and Uncertainty

Metric 7:
Metadata Completeness
N/A

Metric 1: Methodology
High
X
1
1
EPA
Domain 2: Representative

Metric 2: Geographic Scope
High
X
1
1
US
Metric 3: Applicability
High
X
2
2
Manufacturing in scope
Metric 4: Temporal Representativeness
Low
X
2
6
1989
Metric 5: Sample Size
N/A

N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity

Metric 6: Metadata Completeness
High
X
1
1
Data sources included
Domain 4: Variability and Uncertainty

Metric 7: Metadata Completeness
N/A

N/A
This metric is not applicable to this data type
Overall Quality Determination1
High

1.6

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Midwest Research Institute (MRI). 1998. Emission Factor Documentation for AP-42. Section 9.2.1: Fertilizer Application.
Draft Report.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5097883
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Fertilizer application
Methods of application are detailed in Section 2.2. Although many types
of fertilizers are manufactured, the basic application methods depend
on whether the fertilizer is in gaseous, fluid, or solid form. Methods for
application of each of these three forms of fertilizer are discussed.
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Prepared for EPA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
In scope
1998
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Assessment or report clearly documents its data sources, as-
sessment methods, results, and assumptions
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
x 1
1
Includes discussion of limitations to these estiamtes /
information
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
599

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Nondestructive Testing (NDT) Resource Center. 2017. What is
NDT?.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure
or Release Data;
Hero ID
5097890

EXTRACTION


Parameter
Data

Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Metal finishing
Process Description:	A nondestructive evaluation (NDE) method would not only locate a
defect, but it would also be used to measure something about that defect
such as its size, shape, and orientation. NDE may be used to determine
material properties, such as fracture toughness, formability, and other
physical characteristics
EVALUATION





Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Low
X
1
3
Data sources not specified
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
not fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A


N/A
This metric is not applicable to this data type
Overall Quality Determination1
High


1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
600

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Kemira. 2018. RE: N-Methylpyrrolidone (NMP) (CASRN 872-50-4). EPA-HQ-OPPT-2016-0743-0085.
Facility; Reports for Data or Information Other than Exposure or Release Data;
5176404
Source Citation:
Type of Data Source
Hero ID
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Processing
Chemical processing, excluding formulation (polymer manufacturing)
nMethylpyrrolidone (nMP) is an industrial solvent that is used in a
very narrow application. Specifically, it is the preferred sovent for phe-
nothaizine (PTZ), the short-stop chemical for glacial acrylic acid (GAA)
and glacial methamlic acid (GMA). In case of an uncontrolled polymer-
ization within the storage tank, the PTZ can be injected in an attempt
to stop this reaction and prevent a tank rupture.
65 percent
EVALUATION

Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Variability and uncertainty in concentration not addressed.
Overall Quality Determination^
High
1.4
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
601

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: JSR and JSR Micro Inc.. 2017. Comments on the preliminary information on manufacturing, processing, use, and disposal:
N-Methylpyrrolidone (NMP). EPA-HQ-OPPT-2016-0743-0064.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176405
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
electronics
NMP is essential as a solvent in alignment film coatings because poly-
imide is soluble in very few other solvents. Used for LCD screen manu-
facturing. Alignment film coating is printed on the glass and baked to
remove various solvents. The volatile NMP during pre-bake and post-
bake process are removed by air emission abatement devices.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: FUJIFILM Electronics Materials USA Inc.. 2017. NMP Use/Application Survey FFEM/FEUP. EPA-HQ-OPPT-2016-0743-
0024.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176406
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Number of Sites:
Batch Size:
Chemical Concentration:
Use
Electronics - semiconductor manufacturing
Processing aid that is not intended to become part of the final product;
Reactant (i.e., used by itself or with other monomers to synthesize an-
other substance); Formulant/additive; Cleaner/degreaser/surface prep
agent. Bulk containers, totes, drums, and bottles.
2 - Texas and California
batch process
10-100 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
603

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Saft American Inc.. 2017. Memorandum to EPA: N-methylpyrrolidone, docket ID number EPA-HQ-OPPT-2016-0743. EPA-
HQ-OPPT-2016-0743-0005.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176407
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Electronics - batteries
NMP is used in the Saft "mixing" process whereas raw powder chemicals,
solvent (NMP), binder and substrates are combined to form a positive
mix.
In 2016 the Cockeysville plant used 46,022.69 kg. While theJacksonville
plant used 296,651 kg
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Prom chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: North America's Building Trades Unions (NABTU). 2017. Re: TSCA scoping and review: Ten priority chemicals. EPA-HQ-
OPPT-2016-0743-0023.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176408
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
all - list of uses in the construction industry
adhesives and sealants; cleaners; coatings; strippers; Soldering flux,
which cleans oxidation from metals; wood preservatives
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
Trade association poll of manufacturers. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Celanese Engineered Materials. 2017. N-methylpyrrolidone (NMP) CASRN: 872-50-4, use, disposal and exposure scenarios.
EPA-HQ-OPPT-2016-0743-0015.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176410
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Processing
Chemical processing, excluding formulation (polymer manufacturing)
NMP is a solvent critical to manufacturing high-temperature poly-
mer Polyphenylene sulfide (PPS). NMP is a solvent used to dissolve
monomers allowing for a polymerization reaction. After use as a re-
action solvent, NMP is recovered in multiple distillation columns and
recycled back to storage tanks for reuse.
26.2 million lbs of PPS; 2,425,000 lbs of NMP in 2016
Residual NMP measured is below 17 ppm
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
From chemical manufacturing company. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High

1.3

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Akin Gump Strauss Hauer & Feld LLP. 2018. Re: EPA docket EPA-HQ-OPPT-2016-0743: N-Methyl-2-pyrrolidone ("NMP")
CAS# 872-50-4 comments regarding the NMP problem formulation document. EPA-HQ-OPPT-2016-0743-0102.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5176411
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
dip cleaning of plastic films
NMP is used to remove residual colorants from the surface of plastic
films following a coloring process. The plastic film, which is initially
colored by moving the material through a solvent"colorant solution, is
cleaned of excess colorant by processing the material through a wash
basin containing NMP. The NMP wash basins are open to allow film
to move to other units for further processing. The NMP in the basin
is cooled to minimize evaporation. After the NMP wash basins, the
product is further washed with water which is collected and routed to
an on-site biological treatment plant.
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Anonymous comment - data, data sources, and/or techniques






used in the assessment or report are not specified
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
In scope
Metric 4:
Temporal Representativeness
High
X
2
2
2017
Metric 5:
Sample Size
N/A


N/A
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	N/A
N/A This metric is not applicable to this data type
Continued on next page
607

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Akin Gump Strauss Hauer & Feld LLP. 2018. Re: EPA docket EPA-HQ-OPPT-2016-0743: N-Methyl-2-pyrrolidone ("NMP"),
CAS# 872-50-4 comments regarding the NMP problem formulation document. EPA-HQ-OPPT-2016-0743-0102.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5176411
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Overall Quality Determination^

High 1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
608

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: American Chemistry Council. 2017. American Chemistry Council comments on the U.S. Environmental Protection Agency's
initial 10 chemicals identified for risk evaluation. EPA-HQ-OPPT-2016-0743-0011.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176412
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Paints, coatings, adhesives
NMP is used as a coalescing aid in antistatic applications. By allowing
particles to coalesce into a more continuous film, NMP enhances an-
tistatic performance by a factor of ten or more compared to solutions
without NMP. NMP is used to control the viscosity of urethane coatings
in the process of making aqueous dispersions.
0.5 percent ; 5-15 percent ; <5 percent ; <1.5 percent ; <0.5 percent ;
<14 percent ; 30-50 percent ; <0.1 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
ACC poll of trade association members. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
Medium
X 1
x 2
x 2
x 1
1
2
2
2
US
In scope
2017
Range with uncertain statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
x 1
2
Limited information on concentration variability
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
609

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: American Chemistry Council. 2017. American Chemistry Council comments on the U.S. Environmental Protection Agency's
initial 10 chemicals identified for risk evaluation. EPA-HQ-OPPT-2016-0743-0011.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176412
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Processing
Chemical processing, excluding formulation (polymer manufacturing)
NMP is capable of dissolving difficult polymers. This makes it ideal
for applications such as dissolving polyester oligomers at an elevated
temperature and then precipitating them to form polyester beads.
High concentrations of NMP may be necessary
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
ACC poll of trade association members. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------
PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation: Alliance of Automobile Manufacturers. 2017. Re: Scope of risk evaluations for ten chemicals designated on December 19,
2016. EPA-HQ-OPPT-2016-0743-0035.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 5176413
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
all - list of uses in the auto industry
According to a blinded analysis involving our members, this chemical
is used in the auto manufacturing process in painting, stripping, and
cleaning. The chemical is used in certain polymers, leather, adhesives,
coatings, bonding agents, inks, and paints in certain components.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
Trade association poll of manufacturers. No bias /errors evi-
dent.
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
In scope
2017
This metric is not applicable to this data type
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Information is from the source
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

-------