PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
xvEPA
United States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Draft Risk Evaluation for
Methylene Chloride
Systematic Review Supplemental File:
Data Quality Evaluation of Physical-Chemical Properties Studies
CASRN: 75-09-2
October 2019
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Table of Contents
Table 1. Physical Form Study Summary for Methylene Chloride	3
Table 2. Melting Point Study Summary for Methylene Chloride	4
Table 3. Boiling Point Study Summary for Methylene Chloride	5
Table 4. Density Study Summary for Methylene Chloride	6
Table 5. Vapor Pressure Study Summary for Methylene Chloride	7
Table 6. Vapor Density Study Summary for Methylene Chloride	8
Table 7. Water Solubility Study Summary for Methylene Chloride	9
Table 8. Octanol-water Partition Coefficient Study Summary for Methylene Chloride	10
Table 9. Henry's Law Constant Study Summary for Methylene Chloride	11
Table 10. Viscosity Study Summary for Methylene Chloride	12
Table 11. Refractive Index Study Summary for Methylene Chloride	13
Table 12. Dielectric Constant Study Summary for Methylene Chloride	14
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Table 1. Physical Form Study Summary for Methylene Chloride
Study Reference:
U.S. Coast Guard (1984). CHRIS hazardous chemical data. U.S.
Department of Transportation. Washington, DC.
Note:
U.S. Coast Guard (1984) reported the physical form of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The information was measured for the
subject chemical substance.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.

The information is consistent with the
nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
Medium
The data collection is from a known
source that lists several reliable
primary sources in its references.
However; individual values are not
cited to their original sources.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is
from a reliable
method.
Not rated
This metric is not applicable to this
information type.
Overall Quality Level
High
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Table 2. Melting Point Study Summary for Methylene Chloride
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs,
and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal
Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only the
confidence of the melting point is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection where data are peer-
reviewed by experts in the field and
are broadly available to the public for
review and use.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 3. Boiling Point Study Summary for Methylene Chloride
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs,
and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal
Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only the
confidence of the boiling point is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection where data are peer-
reviewed by experts in the field and
are broadly available to the public for
review and use.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 4. Density Study Summary for Methylene Chloride
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs,
and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal
Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only the
confidence of the density is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection where data are peer-
reviewed by experts in the field and
are broadly available to the public for
review and use.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 5. Vapor Pressure Study Summary for Methylene Chloride
Study Reference:
Boubh'k, T; Fried, V; Hala, E. (1984). The vapour pressures of pure
substances: Selected values of the temperature dependence of the vapour
pressures of some pure substances in the normal and low pressure region
(2nd Revised ed.). Amsterdam, The Netherlands: Elsevier Science
Publishers.
Note:
Boublik et al. (1984) reported the vapor
jressure of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The value was derived by
interpolation from a peer-reviewed set
of measured vapor pressures (Std.
Dev. = 0.09 mm Hg).
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The value is consistent with the nature
of the substance.

The information or

The data set has been cited to its
original source which is peer-
reviewed. The authors also state that
the quality of the experimental data
was considered before its inclusion in
the data collection.
Evaluation/ Review
data reported has
reliable review.
High
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 6. Vapor Density Study Summary for Methylene Chloride
Study Reference:
Holbrook, MT. (2003). Methylene chloride. In: Kirk-Othmer Encyclopedia
of Chemical Technology. John Wiley & Sons, Inc.
Note:
Holbrook (2003) reported the vapor density of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.

The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection in which results have
been selected by experts based on
their quality and availability.
References to the original sources are
included.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 7. Water Solubility Study Summary for Methylene Chloride
Study Reference:
Horvath, AL. (1982). Halogenated hydrocarbons: solubility-miscibility in
water. Marcel Dekker, Inc. New York, New York.
Note:
Horvath (1982) reported the water solubility of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.

The consistency of the value with data
measured for other similar chemicals
was considered before its inclusion in
the data collection.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The value is from a data collection
where data were peer-reviewed, cited
to original sources, and had their
experimental quality examined before
inclusion.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
High
The method for producing the data is
not biased towards a particular
outcome.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
High
The data collection only includes
values that have been obtained using
reliable and accepted analytical
methods.
Overall Quality Level
High
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Table 8. Octanol-water Partition Coefficient Study Summary for Methylene Chloride
Study Reference:
Hansch, C. (1995). Fundamentals and applications in chemistry and
biology - hydrophobic, electronic and steric constants. In Exploring QSAR.
Washington DC: American Chemical Society Professional Reference
Book/Oxford University Press.
Note:
Hansch (1995) reported the Log Kowof methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection that has been compiled
by experts and includes references to
the original sources. The original
source for this value is a peer-
reviewed journal.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 9. Henry's Law Constant Study Summary for Methylene Chloride
Study Reference:
Leighton, DT; Calo, JM. (1981). Distribution coefficients of chlorinated
hydrocarbons in dilute air-water systems for groundwater contamination
applications.
Note:
Leighton and Calo (1981) reported the Henry's Law constant as a dimensionless
value and it has been converted to atm-m3/mol.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The value was measured for the
subject chemical substance.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The source is a peer-reviewed journal.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
High
The method for producing this value
is not biased towards a particular
outcome.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
High
The analytical method used to
measure this value is an accepted
standard method.
Overall Quality Level
High
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Table 10. Viscosity Study Summary for Methylene Chloride
Study Reference:
Rossberg, M., Lendle, W., Pfleiderer, A., Togel, A. (2011). Chloromethanes.
In: Ullmann's Encyclopedia of Industrial Chemicals. Wiley-VCH Verlag
GmbH & Co.
Note:
Rossberg et al. (2011) reported the viscosity of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The value was measured for the
subject chemical substance.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The value was similar to measured
values for chemicals of similar
structure.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The value was from a peer-reviewed
source.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 11. Refractive Index Study Summary for Methylene Chloride
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs,
and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal
Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only the
confidence of the refractive index is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Comment

Low,
Unacceptable,
or Not rated]

Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The data was measured for the
substance of interest.
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.
High
The measured value is consistent with
the nature of the substance.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a recognized
data collection where data are peer-
reviewed by experts in the field and
are broadly available to the public for
review and use.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
Not rated
Data source does not provide
information to determine the method
objectivity (unbiased method). Thus,
the domain/metric was not rated.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
Low
Data source does not provide
information regarding the analytical
method.
Overall Quality Level
High
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Table 12. Dielectric Constant Study Summary for Methylene Chloride
Study Reference:
Laurence et al. (1994). The empirical treatment of solvent-solute
interactions: 15 years of pi*. J Phys Chem 98: 5807-5816.
Note:
Laurence et al. (1994) reported the dielectric constant of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the data
and chemical
substance type.
High
The value was measured for the
substance of interest
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features or
behaviors.

The value was similar to those
measured for structurally similar
compounds.
Evaluation/ Review
The information or
data reported has
reliable review.
High
The information is from a peer-
reviewed j ournal.
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards a
particular product or
outcome.
High
The methodology for producing the
information is designed to answer a
specific question.
Reliability/
Analytic Method
The information or
data reported is from
a reliable method.
High
The value was obtained by an
accepted standard analytical method.
Overall Quality Level
High
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