Annotated Reference Outline for the Toxicological Review of 2, 3, 3-Trimethylpentane (cas No. 560-21-4) in Support of Summary Information on the Integrated Risk Information System (iris)


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ANNOTATED REFERENCE OUTLINE
FOR THE TOXICOLOGICAL REVIEW
OF
2,3,3-T rimethylpentane
(CAS No. 560-21-4)
In Support of Summary Information on the
Integrated Risk Information System (IRIS)
12/22/08
[author: insert current date for this draft or Agency completion date (month and year) iffinal]
NOTICE
This document is a [author: insert Agency Review or external review] draft. It has not been
formally released by the U.S. Environmental Protection Agency and should not at this stage be
construed to represent Agency position on this chemical. It is being circulated for review of its
technical accuracy and science policy implications.
U.S. Environmental Protection Agency
Washington, DC

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REVIEWS
ACGIH. (2001) Octane, all isomers. ACGIH. Documentation of the threshold limit values and
biological exposure indices. In: Cincinnati, OH: American Conference of Governmental
Industrial Hygienists; p. 2.
ACGIH. (2007) Octane, all isomers. Threshold limit values for chemical substances and physical
agents and biological exposure indices. In: Cincinnati, OH: American Conference of
Governmental Industrial Hygienists; p. 45.
2. CHEMICAL AND PHYSICAL INFORMATION
3. TOXICOKINETICS
3.1.	ABSORPTION
3.2.	DISTRIBUTION
3.3.	METABOLISM
3.4.	ELIMINATION
Phillips, M; Greenberg, J; Awad, J. (1994) Metabolic and environmental origins of volatile
organic compounds in breath. Journal of Clinical Pathology (London) 47(11): 1052-1053.
Phillips, M; Herrera, J; Krishnan, S; et al. (1999) Variation in volatile organic compounds in the
breath of normal humans. Journal of Chromatography B 729(l-2):75-88.
3.5.	PHYSIOLOGICALLY BASED TOXICOKINETIC MODELS
4. HAZARD IDENTIFICATION
4.1. STUDIES IN HUMANS—EPIDEMIOLOGY, CASE REPORTS, CLINICAL
CONTROLS
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4.2.	LESS-THAN-LIFETIME AND CHRONIC STUDIES AND CANCER BIOASSAYS
IN ANIMALS—ORAL AND INHALATION
4.2.1.	Oral
4.2.2.	Inhalation
4.3.	REPRODUCTIVE/DEVELOPMENTAL STUDIES—ORAL AND INHALATION
4.4.	OTHER ENDPOINT-SPECIFIC STUDIES
4.4.1.	ACUTE AND SHORT-TERM TOXICITY
Bomhard, E; Marsmann, M; Ruehl-Fehlert, C; et al. (1990) Relationships between structure and
induction of hyaline droplet accumulation in the renal cortex of male rats by aliphatic and
alicyclic hydrocarbons. Arch Toxicol 64(7):530-538.
4.4.2.	GENOTOXICITY STUDIES
4.4.3.	NEUROTOXICITY STUDIES
4.4.4.	ENDOCRINE DISRUPTION
4.4.5.	CONTACT SENSITIZATION
4.5.	MECHANISTIC DATA AND OTHER STUDIES IN SUPPORT OF THE MODE OF
ACTION
4.6.	SYNTHESIS OF MAJOR NONCANCER EFFECTS
4.6.1.	Oral
4.6.2.	Inhalation
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4.6.3. Mode of Action Information
4.7.	EVALUATION OF CARCINOGENICITY
4.7.1.	Summary of Overall Weight-of-Evidence
4.7.2.	Synthesis of Human, Animal, and Other Supporting Evidence
4.7.3.	Mode of Action Information
4.7.2.1.	Hypothesized Mode of Action
4.7.2.2.	Experimental Support for the Hypothesized Mode of Action
4.7.2.3.	Other Possible Modes of Action
4.7.2.4.	Conclusions About the Hypothesized Mode of Action
4.8.	SUSCEPTIBLE POPULATIONS AND LIFE STAGES
4.8.3. Other
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