PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
svEPA
United States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Draft Risk Evaluation for
N-Methylpyrrolidone
Systematic Review Supplemental File:
Data Extraction of Epidemiologic Studies
CASRN 872-50-4
October 2019
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Target Organ/
System
Outcome/ Endpoint
Study Population
Exposure
Results
Reference
Data Quality
Evaluation
Hepatic
Gamma glutamyl transferase
(GGT) expression (in IU/1) was
measured in serum as an
indication of liver function
Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60
Measured in air and via
biomonitoring, daily NMP
inhalation exposure median
0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39
mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)
Positive association
between NMP and GGT
expression, not statistically
significant
(Haufroid
et at. 20.1.4)
Medium
Musculoskeletal/M
otor Function
Motor nerve conductivity
velocity
Cross-sectional, 14 factory
workers, Japan 2009, 5 day
study
Measured in air and via
biomonitoring, daily NMP
inhalation exposure means
of 0.14-0.26 ppm, with
maximum exposure of
0.80ppm, urine biomarkers
show NMP/creatinine
geometric mean of 0.081
mg/g creatinine
Positive association with
mean conductivity velocity,
not statistically significant
(Nisfaimiira
et a.L 2009)
Medium
Neurological/Beha
vior
Self-rated depression scale
Cross-sectional, 14 factory
workers, Japan 2009, 5 day
study
Measured in air and via
biomonitoring, daily NMP
inhalation exposure means
of 0.14-0.26 ppm, with
maximum exposure of
0.80ppm, urine biomarkers
show NMP/creatinine
geometric mean of 0.081
mg/g creatinine
Negative association with
depression score,
statistically significant but
stated to not be associated
with NMP levels in logistic
regression models (data not
provided)
(Nishimura
et aL 2009)
Medium
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Target Organ/
System
Outcome/ Endpoint
Study Population
Exposure
Results
Reference
Data Quality
Evaluation
Renal
Serum creatinine (mg/dl) was
measured as an indicator of
kidney function
Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60
Measured in air and via
biomonitoring, daily NMP
inhalation exposure median
0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39
mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)
Positive association
between NMP and serum
creatinine levels, not
statistically significant
(Haufroid
et at. 20.1.4)
Medium
Respiratory
Forced expiratory volume in
1st second of spirometry
(FEV1)
Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60
Measured in air and via
biomonitoring, daily NMP
inhalation exposure median
0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39
mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)
Negative association
between NMP and FEV1,
not statistically significant
(Haufroid
et at. 20.1.4)
Medium
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References
Haufroid- V: Jaeger. VK: Jeggli. S; Eisenegger. R: Bernard. A; Friedli. D: Lison. D: Hotz. P. (2014). Biological monitoring and health effects of
low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study. Int Arch Occup Environ Health 87: 663-674.
http://dx.doi.org/10.1007/s00420-013-0906-5
Mshimura., S; Yasui. H; Mivauchi. H; Kikucht Y; Kondo. N; Takebavashi. T; Tanaka. S; Mikoshiba.. Y; Omae. K; Nomivama, T. (2009). A cross-
sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Ind Health 47: 355-362.
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