PEER REVIEW DRAFT - DO NOT CITE OR QUOTE svEPA United States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention Draft Risk Evaluation for N-Methylpyrrolidone Systematic Review Supplemental File: Data Extraction of Epidemiologic Studies CASRN 872-50-4 October 2019 1 ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Target Organ/ System Outcome/ Endpoint Study Population Exposure Results Reference Data Quality Evaluation Hepatic Gamma glutamyl transferase (GGT) expression (in IU/1) was measured in serum as an indication of liver function Cross-sectional, 8 male workers, Switzerland 2006- 2011, ages 22-60 Measured in air and via biomonitoring, daily NMP inhalation exposure median 0.18 mg/m3, urine metabolite biomarkers show NMP/creatinine medians before and after shift: 0.39 mg/g and 0.27 mg/g (5- HNMP), 0.56 mg/g and 1.06 mg/g (2-HMSI) Positive association between NMP and GGT expression, not statistically significant (Haufroid et at. 20.1.4) Medium Musculoskeletal/M otor Function Motor nerve conductivity velocity Cross-sectional, 14 factory workers, Japan 2009, 5 day study Measured in air and via biomonitoring, daily NMP inhalation exposure means of 0.14-0.26 ppm, with maximum exposure of 0.80ppm, urine biomarkers show NMP/creatinine geometric mean of 0.081 mg/g creatinine Positive association with mean conductivity velocity, not statistically significant (Nisfaimiira et a.L 2009) Medium Neurological/Beha vior Self-rated depression scale Cross-sectional, 14 factory workers, Japan 2009, 5 day study Measured in air and via biomonitoring, daily NMP inhalation exposure means of 0.14-0.26 ppm, with maximum exposure of 0.80ppm, urine biomarkers show NMP/creatinine geometric mean of 0.081 mg/g creatinine Negative association with depression score, statistically significant but stated to not be associated with NMP levels in logistic regression models (data not provided) (Nishimura et aL 2009) Medium 2 ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE Target Organ/ System Outcome/ Endpoint Study Population Exposure Results Reference Data Quality Evaluation Renal Serum creatinine (mg/dl) was measured as an indicator of kidney function Cross-sectional, 8 male workers, Switzerland 2006- 2011, ages 22-60 Measured in air and via biomonitoring, daily NMP inhalation exposure median 0.18 mg/m3, urine metabolite biomarkers show NMP/creatinine medians before and after shift: 0.39 mg/g and 0.27 mg/g (5- HNMP), 0.56 mg/g and 1.06 mg/g (2-HMSI) Positive association between NMP and serum creatinine levels, not statistically significant (Haufroid et at. 20.1.4) Medium Respiratory Forced expiratory volume in 1st second of spirometry (FEV1) Cross-sectional, 8 male workers, Switzerland 2006- 2011, ages 22-60 Measured in air and via biomonitoring, daily NMP inhalation exposure median 0.18 mg/m3, urine metabolite biomarkers show NMP/creatinine medians before and after shift: 0.39 mg/g and 0.27 mg/g (5- HNMP), 0.56 mg/g and 1.06 mg/g (2-HMSI) Negative association between NMP and FEV1, not statistically significant (Haufroid et at. 20.1.4) Medium 3 ------- PEER REVIEW DRAFT - DO NOT CITE OR QUOTE References Haufroid- V: Jaeger. VK: Jeggli. S; Eisenegger. R: Bernard. A; Friedli. D: Lison. D: Hotz. P. (2014). Biological monitoring and health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study. Int Arch Occup Environ Health 87: 663-674. http://dx.doi.org/10.1007/s00420-013-0906-5 Mshimura., S; Yasui. H; Mivauchi. H; Kikucht Y; Kondo. N; Takebavashi. T; Tanaka. S; Mikoshiba.. Y; Omae. K; Nomivama, T. (2009). A cross- sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Ind Health 47: 355-362. 4 ------- |