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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460
Pesticide Fact Sheet
OFFICE OF
PREVENTION, PESTICIDES
AND TOXIC SUBSTANCES
Name of Chemical:
Reason for Issuance:
Dated Issued
Mandipropamid
New Chemical
January 2008
Description of Chemical
Generic Name:
Common Name:
Chemical Class:
EPA Chemical Code:
CAS Number:
Registration Status:
Pesticide Type:
U.S. Producer:
Mandipropamid [4-chloro-N-[2-[3-methoxy-4-(2-
propynyloxy)phenyl]ethyl]a-(2-propynyloxyl)-
b enzeneacetami de]
Mandipropamid
Mandel amide
036602
34726-62-2
New Chemical Registration
Fungicide
Syngenta Crop Protection
P.O. Box 18300
Greensboro, NC 27419
Tolerances Established
Tolerances were established for Mandipropamid in the 40 CFR 180.637 as summarized below:
Tolerances for combined residues of Mandipropamid:
Brassica, Head and Stem, Subgroup 5A	3 ppm
Brassica, Leafy Greens, Subgroup 5B	25 ppm
Vegetable, Cucurbit, Group 9	0.6 ppm
Vegetable, Fruiting, Group 8	1 ppm
Vegetable, Leafy, except Brassica, Group 4	20 ppm
Vegetable, Tuberous and Corm, Subgroup 1C	0.01 ppm
Grape	1.4 ppm

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2
Grape, raisin
Onion, dry bulb
Onion, green
Okra
Potato, wet peel
4 ppm
1 ppm
3 ppm
0.05 ppm
0.03 ppm
Use Patterns and Formulations
Mandipropamid is a new fungicide in the mandelamide class developed by Syngenta Crop
Protection, Inc. for the control of foliar oomycete pathogens in a range of crops including
Plasmopara viticola in grapes, Phytophthora infestans in potatoes and tomatoes, and
Pseudoperonospora cubensis in cucurbits. Mandipropamid is also proposed for uses on leafy
vegetables to control downy mildew (Bremia lactucae) and blue mold (Peronospora effuse).
There is one technical and one end use product to be registered in the U.S. The end-use product
(EP) associated with these petitions is Mandy Flowable Fungicide, which contains 23.3% active
ingredient (2.08 lb ai/gal). The EP is proposed for multiple foliar applications using ground,
irrigation, or aerial equipment at a maximum seasonal rate of 0.52 lb ai/acre for all crops except
green onions for which a maximum seasonal rate of 0.39 lb ai/acre is proposed. The proposed
preharvest intervals (PHIs) range from 0 day (cucurbits) to 14 days (grapes; tuberous and corm
vegetables). No residential uses are proposed.
A tolerance for tomato paste was requested by Syngenta, however, the maximum expected
residue in tomato paste and puree resulting from the proposed use will be covered by the
recommended tolerance for vegetable, fruiting, crop group 8.
A separate tolerance is being established for potato, wet peel, even though it was not requested.
The maximum expected residue in potato wet peel resulting from the use on potato is 0.03 ppm
which was calculated by multiplying the Highest Average Field Trial (HAFT) <0.01 ppm by the
observed concentration factor of >3x. Potatoes have a separate tolerance under the vegetable,
tuberous and corm subgroup 1C.
Okra is listed on the proposed label as a member of the fruiting vegetables. However, a separate
tolerance for okra is being established until the new crop group regulation is published.

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3
Table 1. Details of Proposed Uses of 2.08 lb ai/gal flowable formulation (Mandy Flowable Fungicide).
Application Timing,
Type, and Equipment
Maximum Single
Application Rate
(lb ai/A)
Maximum Number
of Applications per
Season
Maximum Seasonal
Application Rate
(lb ai/A)
PHI
(days)
Brassica, Head and Stem Subgroup (Broccoli. Chinese broccoli (gai Ion). Brussels sprouts, cabbage. Chinese
cabbage (napa). Chinese mustard cabbage (gai choy). cauliflower, ca.va.lo broccoli, and kohlrabi)
Brassica, Leafy Greens, Subgroup (Broccoli raab. Chinese cabbage, collards. kale, mi/una. mustard greens,
mustard spinach, and rape greens - including all cullivars and/or hybrids of these)
Postemergence
Foliar spray
Ground, aerial, or
chemigation
0.13
41
0.52
1
Use Directions and Restrictions: For resistance management, do not apply more than
two applications of Mandy before alternation with at least one application of a fungicide
that is not in Group 40. Applications should begin prior to disease development and
continue throughout the season on a 7-10 day schedule of fungicides, following the
resistance management guidelines. A silicone-based adjuvant should be added at
recommended rates.
Dry Bulb (bulb onion, garlic, and shallot)
Green Onion (green onions, leek, and Welch onion)
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41 for dry bulb
vegetables;
31 for green onions
0.52 for dry bulb
vegetables;
0.39 for green onions
7
Use Directions and Restrictions: For resistance management, do not apply more than
two applications of Mandy before alternation with at least one application of a fungicide
that is not in Group 40. Applications should begin prior to disease development and
continue throughout the season on a 7-10 day schedule of fungicides, following the
resistance management guidelines. A silicone-based adjuvant should be added at
recommended rates.
Cucurbits (cantaloupe, chayole. Chinese waxgourd. cucumber, gourds, honey dew melons. Momordica spp. (bitter
melon, balsam apple), nuiskmelon. watermelon, pumpkin, squash, and zucchini - including all cullivars and/or
hybrids of these)
Fruiting Vegetables (pepper |bell, non-bell, and sweet non-bell|. eggplant, okra. groundcherry. and pepino: see
below for specific proposed use on tomatoes)
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41
0.52
1
Use Directions and Restrictions: For resistance management, do not apply more than
two applications of Mandy before alternation with at least one application of a fungicide
that is not in Group 40. Applications should begin prior to disease development and
continue throughout the season on a 7-10 day schedule of fungicides, following the
resistance management guidelines. When disease epidemics are severe, tank mix
Mandy with another fungicide that is efficacious for disease control. For Phytopthora
blight control, Mandy should always be tank mixed to provide adequate control. A non-
ionic surfactant may be added at recommended rates.
Tomato (including lomalillo)
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41
0.52
1
Use Directions and Restrictions: For resistance management, do not apply more than
two sequential applications of Mandy or any other Group 40 (CAA) fungicide before
alternation with at least two applications of a fungicide that is not in Group 40

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4
Table 1. Details of Proposed Uses of 2.08 lb ai/gal flowable formulation (Mandy Flowable Fungicide).
Application Timing,
Type, and Equipment
Maximum Single
Application Rate
(lb ai/A)
Maximum Number
of Applications per
Season
Maximum Seasonal
Application Rate
(lb ai/A)
PHI
(days)

Applications should begin prior to disease development and continue throughout the
season on a 7-10 day schedule of fungicides, following the resistance management
guidelines. A non-ionic surfactant may be added at recommended rates.
Grapes
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41
0.52
14
Use Directions and Restrictions: For resistance management, do not apply more than
two applications of Mandy before alternation with at least one application of a fungicide
that is not in Group 40. Applications should begin prior to disease development and
continue throughout the season on a 7-10 day schedule of fungicides, following the
resistance management guidelines. A non-ionic surfactant may be added at
recommended rates.
Vegetables, Leafy, except lirassiea (amaranth, arugula. cardoon. celery (Chinese), celtuce, chervil.
chrysanthemum (edible-leaved and garland), corn salad, cress (garden and upland), dandelion, dock,
endive, fennel (Florence), lettuce, orach, parsel. purslane (garden and winter), radicchio (red chicory),
rhubard. spinach (New Zealand and vine). Swiss chard.)
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41
0.52
1
Use Directions and Restrictions: For resistance management, do not apply more than
two applications of Mandy before alternation with at least one application of a fungicide
that is not in Group 40. Applications should begin prior to disease development
and continue throughout the season on a 7-10 day schedule of fungicides, following the
resistance management guidelines. A non-ionic surfactant may be added at
recommended rates.
Vegetables, Tuberous and Corm, Subgroup (arracacha. arrowroot, artichoke (Chinese and Jerusalem), burdock,
carina. cassava (edible, bitter, and sweet), chayolc (root), chiila. dashccn (taro). ginger, leren. potato,
sweet potato, lanicr. turmeric, and yam (bean and true))
Postemergence
Foliar spray
Ground, aerial, or
Chemigation
0.13
41
0.52
14
Use Directions and Restrictions: For resistance management, do not apply more than
two sequential applications of Mandy or any other Group 40 (CAA) fungicide before
alternation with at least two applications of a fungicide that is not in Group 40.
Applications should begin prior to disease development and continue throughout the
season on a 7-10 day schedule of fungicides, following the resistance management
guidelines. A non-ionic surfactant may be added at recommended rates.
A maximum number of uses were not specified on the labels; however, based on the residue data, the application
rate, and the seasonal maximum use rate, the number of applications specified in this table should be reflected on the labels.
Science Findings
The toxicity data base for mandipropamid is adequate for risk assessment and tolerance setting.
Mandipropamid has low or minimal acute toxicity via the oral (Category IV), dermal (Category
IV), and inhalation routes of exposure (Category IV). It is minimally irritating to the eye
(Category IV) and non-irritating to the skin (Category IV); however, it is classified as a skin
sensitizer.

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5
The database is adequate to characterize potential pre-and/or post-natal risk for infants and
children. Acceptable/guideline developmental toxicity study in rats and rabbits and a
reproduction study in rats, as well as acute and subchronic neurotoxicity studies in rats were
available for FQPA assessment.
Available product chemistry and toxicology data supporting the proposed tolerance are
summarized below:
Structure and Nomenclature
Table 2. Test Compound Nomenclature.
Compound

Common name
Mandipropamid
HC^
Company experimental name
NOA 446510
IUPAC name
(/^S')-2-(4-chloro-phcnvl)-\-|2-(3-incthoxy-4-prop-2-ynvlox\-phcnvl)-ethvl|-2-
prop-2-ynyloxy-acetamide
CAS name
4-chloro-iV-[2-[3-methoxy-4-(2-propynyloxy)phenyl]ethyl]-a-(2-propynyloxy)-
benzeneacetamide
CAS registry number
374726-62-2
End-use product (EP)
Mandy Flowable Fungicide (2.08 lb/gal; EPA Reg. No. 100-1254),
(Alternate Brand Name: Revus)

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6
Physical and Chemical Properties
Table 3. Physical and chemical Properties of the Technical Grade of Mandipropamid.
Parameter
Value
Reference
Melting point/range
96.4-97.3C
MRID 46800006
Molecular formula/weight
C23H22C1N04 / 411.9

pH
6-8 at 25C (1% aqueous dispersion)

Density
1.24 x 103 kg/m3 at 22C

Water solubility (25C)
4.2 mg/L

Solvent solubility (25C)
n-hexane 42 mg/L
n-octanol 4.8 g/L
toluene 29 g/L
methanol 66 g/L
ethyl acetate 120 g/L
acetone 300 g/L
dichloromethane 400 g/L

Vapor pressure
<9.4 x 10"7 Pa at 25C or <7.0 x 10"9 niniHg

Dissociation constant, pKa
No dissociation constant in the pH range of 1 to
12

Octanol/water partition coefficient,
Log(Pow)
3.3 at 25C

Toxicological Characteristics
Mandipropamid has low or minimal acute toxicity via the oral (Category IV), dermal (Category
IV), and inhalation routes of exposure (Category IV). It is minimally irritating to the eye
(Category IV) and non-irritating to the skin (Category IV); it is a skin sensitizer.
Liver toxicity is the primary effect and was observed in rats, mice and dogs. In a 90-day rat
dietary study, there was slight hepatotoxicity in both sexes at 260 mg/kg/day (NOAEL =
41/45 mg/kg/day, M/F). There was the suggestion of effects on the liver in the 90-day mouse
dietary study (increased liver weights in both sexes and microscopic pathology) at
624/800 mg/kg/day (M/F), with the NOAEL = 248/316 mg/kg/day (M/F). The 90-day dog study
showed (capsule) increased cholesterol, increased liver weights and liver enzymes (alkaline
phosphatase activity, alanine aminotransferase) and increased pigment in hepatocytes and
Kupffer cells in both sexes at 400 mg/kg/day. Additionally, centrilobular hepatocyte vacuolation
in females was observed at 400 mg/kg/day with the NOAEL = 100 mg/kg/day.
In the combined chronic/carcinogenicity dietary rat study, no effects on the liver were
noted at doses up to and including the HDT of 61/70 mg/kg/day (M/F); however, increased
nephrotoxicity occurred in males. No liver effects were observed in the 18-month mouse dietary
admix carcinogenicity study at doses up to 223/285 mg/kg/day (M/F). The following effects on
the liver were present in the 1-year dog study (capsule) at 40 mg/kg/day (NOAEL = 5

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7
mg/kg/day): increased incidence and severity of microscopic pigment in the liver and increased
alkaline phosphatase activity in both sexes, as well as increased alanine aminotransferase activity
in males. In the 24-month rat study, only nephrotoxicity was observed. In the 18-month
mouse study, the only ffects seen were decreases in body weight and food utilization.
There was no evidence of teratogenicity or indications of increased neonatal sensitivity in the
developmental and reproduction toxicity studies. In the rat and rabbit developmental toxicity
studies, no maternal or developmental effects were observed at the limit dose of 1000 mg/kg/day.
In the two-generation rat reproduction study, the only parental/systemic effects were decreased
body weights, body weight gains, food consumption and food utilization in males at the LOAEL
of 146/148 mg/kg/day (M/F)(NOAEL = 23/25 mg/kg/day, M/F). No effects on reproduction
were observed at any dose. There were decreased pup body weights in both sexes observed at
the LOAEL of 146/148 mg/kg/day (M/F). In addition, there was a delay in prepucial separation
in Fi males (group mean days: control = 43.7; 146 mg/kg/day = 44.8) which was considered to
be the result of lower body weights.
Dermal exposure to mandipropamid for 28 days in the rat did not result in systemic or dermal
toxicity up to the limit dose of 1000 mg/kg/day.
There was no evidence of neurotoxicity, mutagenicity or carcinogenicity after exposure to
mandipropamid. In addition, there was no estrogen-, androgen-, and/or thyroid-mediated
toxicity.
Table 4 Acute Toxicity Profile - Test Substance
Guideline No.
Study Type
MRID(s)
Results
Toxicity Category
870.1100
Acute oral rat
46800201
LD50 > 5000
mg/kg
IV
870.1200
Acute dermal rat
46800202
LD50 > 5050
mg/kg
IV
870.1300
Acute inhalation rat
46800204
LC50 > 5.19 
0.55 mg/L
IV
870.2400
Acute eye irritation rabbit
46800206
Iritis and positive
signs of
conjunctivitis
clearing within
24 hours.
IV
870.2500
Acute dermal irritation rabbit
46800208
PDI = 0.33
IV
870.2600
Skin sensitization guinea pig
46800210
Sensitizer
N/A
870.2600
Skin sensitization mouse
46800212
Not acceptable
N/A
N/A -- not applicable.

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8
Talile5. Siilichronie. Chronic and Oilier To\ici(\ Profile lor Maii(li|iro|iami(l
(iiiiriclinc
No.
Siiulj \ \ lie
MKII) No.
(year)/
( lassil'icalion
Dose let els
Results
870.3100a
90-Day oral
toxicity (rat)
46800216
(2005)
Acceptable/
Guideline
ppm= 0, 100, 500,
3000, 5000
mg/kg/day=
M: 0, 8,41,260,
435
F: 0, 9, 45, 260,
444
NO A F.I. = 41/45 mg/kg/day M/F
LOAEL = 260 mg/kg/day both sexes,
based on decreased body weights,
weight gains and food utilization in
males and slight hepatotoxicity in both
sexes
30.3100
28-Day oral
toxicity (rat)
46800214
(2005)
Acceptable/
Guideline
ppm = 0, 1000,
3000, 10,000,
16,000 [10,000 &
16,000 died < day
4]
mg/kg/day =
M: 0, 135,418,
624, 604
F: 0, 121,381,784,
1410
NOAEL = not established
LOAEL = M=135, F=121 mg/kg/day,
based on decreased food consumption
in both sexes and decreased body
weights and weight gains in males
(liver changes at 418/381 mg/kg/day
M/F).
870.3100a
90-Day oral
toxicity (mouse)
46800213
46800217
(2005)
Acceptable/
Guideline
ppm= 0, 300, 800,
2000, 5000
mg/kg/day=
M: 0, 37, 98, 248,
624
F: 0, 47, 129,316,
800
NOAEL = M/F = 248/316 mg/kg/day
LOAEL = M/F = 624/800 mg/kg/day,
based on decreased body weight gain
in males and females (as well as the
suggestion of effects on the liver:
increased weights in both sexes and
microscopic pathology).
870.3150
90-Day oral
toxicity (dog)
46800218
46800219
46800220
(2005)
Acceptable/
Guideline
mg/kg/day=
0, 5, 25, 100, 400
(capsule)
NOAEL =100 mg/kg/day
LOAEL = 400 mg/kg/day, based on
liver toxicity (increased cholesterol,
alkaline phosphatase activity, ALT
activity, liver weights and microscopic
pigment in hepatocytes and Kupffer
cells in both sexes and centrilobular
hepatocyte vacuolation in females).
870.3200
21/28-Day dermal
toxicity (rat)
46800222
46800221
(2005)
Acceptable/
Guideline
mg/kg/day=
0, 250, 500, 1000
(limit dose)
Systemic/Dermal NOAEL = 1000
mg/kg/day
LOAEL = not determined
870.3700a
Prenatal
developmental
(rat)
46800224
46800223
(2005)
46800228
(2001)
Acceptable/
Guideline
mg/kg/day=
0, 50, 200, 1000
Maternal NOAEL = 1000 mg/kg/day
LOAEL = not determined
Developmental NOAEL = 1000
mg/kg/day
LOAEL = not determined

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9
Tiil>k'5. Sulichronic. Chronic and Oilier To\ici(\ Profile lor Mandipropamid
(iuidcline
No.
Smdj \ \ pe
MKII) No.
(year)/
( lassil'icalion
Dose let els
Results
870.3700b
Prenatal
developmental
(rabbit)
46800227
46800225
46800226
46800229
(2005)
Acceptable/
Guideline
mg/kg/day=
0, 50, 250, 1000
Maternal NOAEL = 1000 mg/kg/day
LOAEL = not determined
Developmental NOAEL = 1000
mg/kg/day
LOAEL = not determined
870.3800
Reproduction and
fertility effects
(rat)
46800230
46800231
(2005)
Acceptable/
Guideline
ppm=(males/
females)
0, 50, 250, 1500
mg/kg/day=
(mean of premating
both sets of
parents) = 0/0,
4.6/5.0, 22.9/24.5,
146.3/148.2
Parental/Systemic NOAEL = M/F =
22.9/24.5 mg/kg/day
LOAEL = M/F = 146.3/148.2
mg/kg/day, based on decreased body
weights, weight gains, food
consumption and food utilization in
males
Reproductive NOAEL = M =
146.3/148.2 mg/kg/day
LOAEL = not determined
Offspring NOAEL = M/F = 22.9/24.5
mg/kg/day
LOAEL = M/F = 146.3/148.2
mg/kg/day, based on decreased pup
body weights in both sexes.
870.4100b
Chronic toxicity
(dog)
46800232
(2005)
Acceptable/
Guideline
mg/kg/day=
0, 5, 40, 400
(capsule)
NOAEL = 5 mg/kg/day
LOAEL = 40 mg/kg/day, based on
evidence of liver toxicity (increased
incidence and severity of microscopic
pigment in the liver and increased
alkaline phosphatase activity in both
sexes as well as increased alanine
aminotransferase activity in males).
870.4300
Combined chronic
toxicity/
carcinogenicity
(rat)
46800234
(2005)
Acceptable/
Guideline
ppm = 0, 50, 250,
1000
mg/kg/day= M/F =
0/0, 3.0/3.5,
15.2/17.6,
61.3/69.7
NOAEL = M/F = 15.2/17.6
LOAEL = 61.3/69.7mg/kg/day, based
on decreased body weight gain and
food utilization and increased
nephrotoxicity in males.
There was no evidence of
carcinogenicity in rats.
870.4200b
Carcinogenicity
(mouse)
46800233
(2005)
Acceptable/
Guideline
ppm = 0, 100, 500,
2000
mg/kg/day= M/F =
0/0, 10.6/13.2,
55.2/67.8,
222.7/284.6
NOAEL = M/F = 55/68 mg/kg/day
LOAEL = 223/285 mg/kg/day, based
on decreased body weight gain in both
sexes and decreased food utilization in
males.
There was no evidence of
carcinogenicity in mice.
870.5100
Bacterial Reverse
Mutation Assay
46800235
(2005)
Acceptable/
Guideline
Tested up to limit
dose of 5000
Hg/plate
Negative

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10
Talile5. Siilichronie. Chronic and Oilier To\ici(\ Profile lor Maii(li|iro|iami(l
(iiiiriclinc
No.
Siiulj \ \ la-
MKII) No.
(year)/
( lassil'icalion
Dose let els
Results
870. 5300
in Vitro
Mammalian Cell
Gene Mutation
Test - Mouse
Lymphoma
46800236
(2005)
Acceptable/
Guideline
Tested up to limit
dose (4119 ng/mL)
Negative
870. 5375
In Vitro
Chromosome
Aberration test -
Human Peripheral
Blood
Lymphocytes
46800237
(2002)
Acceptable/
Guideline
Up to cytotoxic
concentrations
Negative
870.5395
Micronucleus
Assay in Rats
46800238
(2005)
Acceptable/
Guideline
Limit dose of 2000
mg/kg
Negative
870.5550
In Vivo/In Vitro
Unscheduled
DNA Synthesis
Assay in Primary
Rat Hepatocytes
46800239
Acceptable/
Guideline
mg/kg = 0 or 2000
Negative
870.6200a
Acute
neurotoxicity
(rats)
46800242
(2005)
46800241
(2003)
Acceptable/
Guideline
mg/kg = 0, 200,
600, 2000 (limit
dose)
NO A F.I. = M/F = 2000 mg/kg
LOAEL = M/F = not observed
870.6200b
Subchronic
neurotoxicity
(rats)
46800240
(2005)
Acceptable/
Guideline
ppm = 0, 100, 500,
2500
mg/kg/day = M/F =
0/0, 7.4/8.4,
37.3/41.0,
192.5/206.7
NO A F.I. = M/F = 37/41 mg/kg/day
LOAEL = M/F = 192/207 mg/kg/day,
based on slightly decreased body
weight, weight gain and food
utilization in males.

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11
Tiil>k'5. Siihchronic. Chronic and Oilier To\ici(\ Profile lor MaiHlipropamiri
(iiiiriclinc
No.
Siiulj \ \pc
MKII) No.
(year)/
( lassil'icalion
Dose lc\cls
Results



870.7485
Metabolism and
pharmacokinetics
(rat)
46800243-
46800246
(2005)
Acceptable/
Guideline
mg/kg/day =
single oral 3 or 300
methoxy label
repeated 3 methoxy
label
single oral 3 or 300
methoxy/chloro
labels
After 48 hours, absorption was 67-
74% at 3 mg/kg and 30-45% at 300
mg/kg. Blood Tmax at 3 mg/kg was 8.5
hours for M and 4.5 hours for F; at
300 mg/kg was 24 hours for M and 10
hours for F (rate of resorption greater
in F; extent and rate greater in low
dose). Recoveries at 168 hours 88-
99% (most eliminated by 48 hours).
Excluding 3 mg/kg F, most excreted in
feces; at 3 mg/kg F, feces and urine
similar. Elimination after 48 hours in
bile was high at 3 mg/kg (55-73%),
but was 22-28% at 300 mg/kg. Liver
had highest concentration at all
measurements. More radioactivity in
plasma than whole blood. Identified
compounds 66-94% of administered
dose in each group (168 hours).
Parent and following metabolites at
>5% at 3 and/or 300 mg/kg: NOA
458422, NOA 458422 glucuronide,
SYN 534133 and CGA 380778.
Differences in metabolic profile due to
sex, dose and radiolabel position.
Each unknown compound < 5%.
Major metabolic transformations
involved loss of one or both propargyl
groups followed by glucuronidation
and O-demethylation.
870.7600
Dermal
Penetration (rat)
46800248
(2005)
Acceptable/
Guideline
Nominal doses:
mg/cm2 skin =
0.00152,0.0076,
2.54.
Spray strength
dilutions of 1/333
and 1/1667 v/v.
Recovery was 96-112%. Minimal
absorption (<0.17 to 3.44% of applied
dose). 91-105% recovered from 6
hour skin wash. Greatest absorption in
1/1667 aqueous dilution 114 hours
after 6 hours of exposure (3.44%
absorbed).
Non-
Guideline
Methods
Development and
Validation for
Dietary
Formulation
Analyses
46800215
(2002)
Acceptable/
Non-Guideline
N/A
Validation of analytical method for
determining concentrations, stability
and homogeneity of test article in
dietary formulations.
Non-
Guideline
In Vitro Dermal
Penetration Study,
Rat epidermis
46800247
(2003)
Acceptable/
Non-Guideline
Hg/cm2 skin = 2570
or 2510
Absorption rate greatest during first 30
minutes of exposure, 0.715-0.746
Hg/cnr/hour. Absorption rates over
24 hours were 0.077-0.091
Hg/cm2/hour.

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12
Tiil>k'5. Siibchronic. Chronic and Oilier To\ici(\ Profile lor Mandipropamid
(.iiidclinc
No.
Sludj Tjpe
MRU) No.
(year)/
( lassificalion
Dose le\cls
Results
Non-
Guideline
In Vitro Dermal
Penetration Study,
Rat epidermis
46800251
(2005)
Acceptable/
Non-Guideline
Hg/cm2 skin= 1.35,
6.69, 2538
Absorption was poor (recovery of
applied radioactivity 99-105%).
Absorption rates over 24 hours were
<0.04 |ig/cm2/hour in concentrate
formulation and 0.01 |ig/cm2/hour in
aqueous spray dilutions.
Non-
Guideline
In Vitro Dermal
Penetration Study,
Pig epidermis
46800249
(2003)
Acceptable/
Non-Guideline
Hg/cm2 skin =
neat: 38,600
in acetone: 39.9
Absorption was poor (<0.01%).
Absorption rate for neat was greatest
during first 4 hours (0.03 |ig/cm2/hour)
and was 0.02 |ig/cm2/hour over 24
hours. Absorption rate for acetone
was 3.58% (first hour = 0.56, 24 hours
= 0.05 iig/cnr/hour). Absorption
enhanced by acetone.
Non-
Guideline
In Vitro Dermal
Penetration Study,
Human epidermis
46800250
(2005)
Acceptable/
Non-Guideline
Hg/cm2 skin= 1.35,
6.69, 2538
Recovery of radioactivity was 95-
102%. Absorption was minimal.
Over 24 hours, absorption was <0.04
Hg/cnr/hour in the concentrate
formulation and <0.001 |ig/cm2/hour
in the aqueous spray dilutions.
Talileft. Toxicologic;!! Doses and l-'.ndpoinls lor Mandipropamid lor I se in Diclan and Non-Occupalional
11 ii ma it llcallh Risk Assessments
r.xposurc/
Scenario
Point of
Departure
1 nccrlainl>/
IOPA Safcl\
l-aclors
RID. PAD. l.e\elol
Concern lor Risk
Asscssmcnl
Sludj and 1 oxicoloiiical I.ITccls
Acute Dietary
(General
Population,
including Infants
and Children)
N/A
N/A
N/A
No aDDroDriate endDoint was
identified.
Acute Dietary
(Females 13-49
years of age)
N/A
N/A
N/A
No aDDroDriate endDoint was
identified.
Chronic Dietary
(All
Populations)
NO A F.I. = 5
mg/kg/day
UFa = 10X
UFh = 10X
FQPA SF = IX
Chronic RfD = 0.05
mg/kg/day
cPAD = 0.05
mg/kg/day
Chronic toxicitv - doss
LOAEL = 40 mg/kg/day, based on
evidence of liver toxicity (increased
incidence and severity of microscopic
pigment in the liver and increased
alkaline phosphatase activity in both
sexes as well as increased alanine
aminotransferase activity in males).
Cancer (oral,
dermal,
inhalation)
"Not Likely to be Carcinogenic to Humans." No treatment-related tumors observed in
carcinogenicity studies in rats and mice. A cancer risk assessment is not needed.
NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from
animal to human (interspecies). UFh = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF =
FQPA Safety Factor. PAD = population adjusted dose (c = chronic). RfD = reference dose. N/A = not applicable.

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13
Table "7. Siimman ol' Toxicologic;!! Doses iinri llndpoinls lor Mandipropamid lor I so in Occupational
lliiniiin 1 lc;i 1 111 Risk Assessments
I'.xposiirc/
Scenario
Poinl ol'
Dcparliirc
1 iiccrl;iiiil>
l-aclors
l.c\ol of Concern
lor Risk
Assessment
Sintl> iind To\icolo;iic;il I.ITcds
Dcmial ^1-30
days) and
Intermediate-
term (1-6
months)
\ A
\ A
\ A
No annronrialc endnoinl was
identified.
28-day dermal toxicity study - rat,
no systemic or dermal effect up to the
limit dose of 1000 mg/kg/day; there
were no neurotoxicity or
developmental concerns.
Inhalation
Short-(1-30
days) and
Intermediate-
term (1-6
months)
NOAEL=
41 mg/kg/day
IAF=100%
UFa = 10X
UFh = 10X
MOE = 100
90-dav oral toxicity - rats
LOAEL = 260 mg/kg/day, based on
decreased body weights, body weight
gains and food utilization in males
and slight hepatotoxicity in both
sexes.
Cancer (oral,
dermal,
inhalation)
"Not Likely to be Carcinogenic to Humans." No treatment-related tumors observed in
carcinogenicity studies in rats and mice. A cancer risk assessment is not needed.
NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from
animal to human (interspecies). UFh = potential variation in sensitivity among members of the human population (intraspecies). MOE = margin
of exposure. LOC = level of concern. N/A = not applicable. IAF=inhalation absorption factor.
Food Quality Protection Act Considerations:
The Agency recommends that the FQPA SF be reduced to IX because there is no evidence of
increased susceptibility, there are no/low concerns and no residuals uncertainties regarding pre-
and/or postnatal toxicity, there is no evidence of neurotoxicity in the database and a DNT study
is not required. In addition, the toxicological database is complete and there is no need for
additional uncertainty factors. Furthermore, the exposure assessments are based on reliable data
and reasonable worst-case assumptions and will not likely underestimate risks.
Exposure Assessment:
Acute Dietary Exposure and Risk: No acute dietary endpoint based on effects attributable to a
single dose could be identified based on the toxicology data currently available for
mandipropamid.
Chronic Dietary Exposure and Risk: A tolerance level (unrefined) chronic exposure assessment
that assumes 100% crop treated was conducted for the proposed Section 3 uses of
mandipropamid. The DEEM analysis incorporates estimates of drinking water concentration
from the Environmental Fate and Effect Division directly into the analysis. The chronic dietary
exposure analysis for mandipropamid results in dietary risk estimates for food

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14
and water that are below the Agency's level of concern for chronic dietary exposure. For
mandipropamid, the DEEM chronic dietary exposure estimate was 22% of the cPAD for the U.S.
population and was 30% of the cPAD for the highest exposed population subgroup, children 1-2
years of age.
Cancer Exposure and Risk: Mandipropamid is classified as not likely to be a human carcinogen.
Therefore, a cancer assessment was not performed.
Residential Exposure and Risk: Residential exposures were not assessed because the proposed
uses of mandipropamid do not involve applications by homeowners or by commercial
applicators in residential settings.
Aggregate Exposure and Risk: The chronic aggregate risk calculations include exposures only
from food and water sources. Acute aggregate and cancer risks were not assessed due to the
absence of an acute dietary endpoint and because mandipropamid is not likely to be carcinogenic
to humans.
Cumulative Exposure and Risk: Section 408(b)(2)(D)(v) of the FFDCA requires that, when
considering whether to establish, modify, or revoke a tolerance, the Agency consider "available
information concerning the cumulative effects" of a particular pesticide's residues and "other
substances that have a common mechanism of toxicity."
Unlike other pesticides for which EPA has followed a cumulative risk approach based on a
common mechanism of toxicity, EPA has not made a common mechanism of toxicity finding as
to mandipropamid and any other substances, and mandipropamid does not appear to produce a
toxic metabolite produced by other substances. For the purposes of this tolerance action,
therefore, EPA has not assumed that mandipropamid has a common mechanism of toxicity with
other substances. For information regarding EPA's efforts to determine which chemicals have a
common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see the
policy statements released by EPA's Office of Pesticide Programs concerning common
mechanism determinations and procedures for cumulating effects from substances found to have
a common mechanism on EPA's website at http://www.epa.gov/pesticides/cumulative/.
Occupational Exposure and Risk: Mandipropamid is a fungicide to be applied as a foliar spray
by aerial equipment, chemigation, groundboom equipment, and airblast equipment.
Occupational exposure is expected to be short (1-30 days) and intermediate-term (1-6 months) in
duration. No long-term (more than 6 months) exposure is expected from the proposed uses in
mandipropamid due to the limited number of applications and fungicide rotation directions.

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15
No chemical-specific exposure data were submitted. Therefore, occupational handler
assessments for mandipropamid were based on surrogate unit exposures from the Pesticide
Handlers Exposure Database (PHED).
Dermal handler exposure and risks were not assessed for mandipropamid, since no short- or
intermediate-term dermal endpoints were identified. All inhalation scenarios were assessed. In
all scenarios except aerial applicator (where adequate baseline or open cockpit data are not
available), short-and intermediate-term inhalation risks resulted in MOEs greater than 100
(53,000-460,000) at the baseline level of personal protective equipment, (PPE) (i.e., no
respirator) and were not of concern to the Agency. Inhalation risks to pilots in enclosed cockpits
with no respirator (engineering control scenario) were not of concern. In this assessment the
Agency assumed the maximum application rates that are on the labels, a 70 kg body weight for
the handler, and an average workday of 8 hours. With respect to aerial applications by open
cockpit, we are not aware of this type of application taking place. Therefore, a label statement
prohibiting open cockpits is not warranted.
Occupational post application risks to agricultural workers following treatments to agricultural
crops were not assessed, since dermal endpoints of concern were not identified.
Short-/Intermediate-Term Handler Risk: Short-and intermediate-term dermal exposures and risk
were not assessed for mandipropamid, since no short- or intermediate-term dermal endpoint was
identified.
Short-/Intermediate-Term Postapplication Risk: Occupational post-application exposures/risks
were not quantified because no appropriate dermal endpoints were identified.
Environmental Fate Characteristics/Ecological Effects
Environmental Fate Summary: Mandipropamid is considered to be persistent in the environment
based on its degradation in soil and water. The major route of dissipation is degradation under
aerobic aquatic conditions. Mandipropamid degrades to several intermediately degradation
products. The transformation products are ultimately degraded to non-extractable residues and
carbon dioxide. Mandipropamid is moderately mobile and some of its metabolites are mobile to
highly mobile in soils, and therefore have the potential to leach into ground water.
Mandipropamid can reach surface waters via spray drift and rainfall events that cause runoff.
a. Hydrolysis/photolysis
Mandipropamid appears to be stable to hydrolysis in the environmental pH range of 5-9, but is
susceptible to photolysis in soil and water. The environmental photolysis half-lives of
mandipropamid in pH 7, 25C aqueous solutions was estimated as 0.63-1.1 days. The soil

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16
photolysis half-lives of mandipropamid was estimated as 16.4-23.9 days. Based on its vapor
pressure and Henry's Law constant, volatilization from water and soil are not expected to be
important environmental fate processes.
b.	Soil/Water Degradation
The linear biodegradation half-life of mandipropamid in six European and one U.S. soils
ranged from approximately 26 to 103 days under aerobic conditions. Based on results from the
supplemental study, under anaerobic conditions the rate of biodegradation appears to be much
slower. Mandipropamid degraded with linear half-lives of 151 days in a silt loam soil from
Switzerland maintained under anaerobic conditions. The aerobic aquatic degradation half-lives
of mandipropamid were 17.8-18.5 days in two river water/silt loam sediment systems from
England and Germany.
c.	Terrestrial Field Dissipation. Studies on mandipropamid were conducted in four bare
plots cropped with field potatoes: in California (sandy loam soil), New York (loamy sandy
soil), and Georgia (sandy loam soil). The field dissipation half-lives of mandipropamid were:
75.3 days (California site); 100.5 days (New York); 81.5 days (Georgia).
Ecological Effects Summary
a.	Avian Acute Toxicity
Mandipropamid is practically nontoxic to birds on an acute oral and acute dietary basis.
b.	Avian Chronic Toxicity
Mandipropamid did not cause any significant chronic effects on reproduction or growth and
survival of chicks at 1060 ppm a.i. which was the highest concentration tested.
c.	Mammalian Acute Toxicity
Mandipropamid is practically nontoxic to mammals on an acute oral toxicity basis.
d.	Mammalian Chronic Toxicity
The results of the mammalian reproductive toxicity study demonstrated a parental system
NOAEL and offspring NOAEL of 250 ppm a.i. based on decreased parental body weights,

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17
decreased parental weight gains, decreased parental food consumption, decreased parental
food utilization, decreased pup body weights in both sexes and delayed sexual maturation in
offspring.
e.	Fish Acute Toxicity
The registrant submitted a freshwater fish chronic toxicity study that demonstrates chronic
exposure to technical mandipropamid causes significant decreases to fish growth at a NOAEC
and LOAEC concentration of 0.21 ppm and 0.45 ppm respectively.
f.	Aquatic Invertebrate Toxicity
The registrant submitted aquatic invertebrate acute toxicity studies demonstrating that technical
mandipropamid is moderately toxic to freshwater invertebrates and very highly to moderately
toxic marine/estuarine invertebrates.
g.	Aquatic Invertebrate Chronic Toxicity
The registrant submitted aquatic invertebrate chronic toxicity data that are invalid. Thus, the
Agency is uncertain about the chronic toxic effects of mandipropamid to aquatic invertebrates.
Ecological Risk Summary
Based on the available data, the Agency has determined that mandipropamid's proposed uses are
not expected to pose significant acute or aquatic risk to birds; acute or chronic risk to mammals;
acute risk to aquatic invertebrates; acute or chronic risk to fish; or acute risk to terrestrial or
aquatic plants. The RQ values for acute risk to aquatic invertebrates, acute risk to plants, and
chronic risk to fish are several orders of magnitude below the Agency LOC. Therefore, no
additional risk mitigation measures are needed and LOCs were not exceeded.
Data Needs and Label Requirements
The registrant will be required to submit the following confirmatory data. All required label
changes have been made. This chemical was found to be a reduced risk chemical, therefore no
public interest finding statement is needed.
1.	Invertebrate chronic toxicity: The submitted Daphnia study is invalid because reproduction
of the dapnids in the solvent control were significantly lower than in the negative control.
2.	Storage Stability Data: Storage stability data for SYN 500003 which covers the entire 32

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18
months of storage (interim storage	stability data for six months were
submitted).
Contact Person at USEPA
Rose Mary Kearns
One Potomac Yard (South Building)
2777 South Crystal Drive
Arlington, VA 22202
703-305-5611
DISCLAIMER: The information in this Pesticide Fact Sheet is for information only and is not to
be used to satisfy data requirements for pesticide regulation. The information is believed to be
accurate as of the date on the document.

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19
Bibliography
mrii)
46800000
46800001
46800002
46800003
46800004
46800005
46800006
46800007
Citation Reference
Syngenta Crop Protection, Inc (2006) Submission of Toxicity, Product
Chemistry and Environmental Fate Data in Support of the Application for
Registration of Mandipropamid and the Petition for Tolerance of
Mandipropamid. Transmittal of 51 Studies.
Schulz, M. (2006) Mandipropamid (MANDY): Reduced Risk Rationale For
Proposed Uses on Brassica Vegetables, Bulb Vegetables, Grapes, Cucurbits,
Fruiting Vegetables, Potatoes, Tomatoes, and Tuberous and Corm Vegetables.
Project Number: T003525/05, ELECTRONIC/COPY. Unpublished study
prepared by Syngenta Crop Protection, Inc. 49 p.
Akins, J.; Chukwudebe, A.; Itterly, W. (2006) Mandipropamid (NOA446510):
Rationale For Reduction of Restricted Entry Interval to Four Hours. Project
Number: TOO 1791/06. Unpublished study prepared by Syngenta Crop
Protection, Inc. lip.
Irrig, H. (2005) Manufacturing Process Description and Supporting Data for
Mandipropamid 250SC (A12946B). Project Number: PC/05/084, 115093,
SF/12/1. Unpublished study prepared by Syngenta Crop Protection, Inc. 202 p.
Irrig, H. (2006) Manufacturing Process Description and Supporting Data for
Mandipropamid Technical. Project Number: PC/06/039, 115083, 115292.
Unpublished study prepared by Syngenta Crop Protection, Inc. 570 p.
Irrig, H. (2005) Physical and Chemical Properties of Mandipropamid 250SC
(A12946B). Project Number: PC/05/085, HT05/163, 114138. Unpublished study
prepared by Syngenta Crop Protection, Inc. 100 p.
Irrig, H. (2006) Physical and Chemical Properties of Mandipropamid Technical.
Project Number: PC/06/040, 109670, 114672. Unpublished study prepared by
Syngenta Crop Protection, Inc. 149 p.
Buckel, T. (2002) Hydrolysis of [Ethyl-1-(Carbon 14)]-Labelled NOA446510
Under Laboratory Conditions: Final Report. Project Number: 02TB01,
T004591/02. Unpublished study prepared by Syngenta Crop Protection, AG. 52

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20
P-
46800008	Murphy, T. (2006) Hydrolysis of [Ethyl-1-(Carbon 14)]-labelled NOA446510
Under Laboratory Conditions. Project Number: T004591/02. Unpublished study
prepared by Syngenta Crop Protection, Inc. 18 p.
46800009	Kuet, S. (2004) NOA446510: Photolysis of (Carbon 14)-Chlorophenyl Ring
Labelled NOA446510 in Sterile Natural Water Under Laboratory Conditions.
Project Number: RJ3510B, T004575/02. Unpublished study prepared by
Syngenta Jealotts Hill International. 101 p.
46800010	Harrison, C. (2004) NOA446510: (Carbon 14)-Methyoxyphenyl Labelled
Sterile Natural Water Photolysis Under Laboratory Conditions: Final Report.
Project Number: RJ3481B, T004607/02. Unpublished study prepared by
Syngenta Jealotts Hill International. 82 p.
46800011	Nicollier, G. (2003) Aqueous Photolysis of [Chlorophenyl-U-(Carbon 14)]-
Labelled NOA446510 Under Laboratory Conditions: Final Report. Project
Number: 02GN07, T004618/02. Unpublished study prepared by Syngenta Crop
Protection, AG. 135 p.
46800012	Murphy, T. (2006) Aqueous Photolysis of [Chlorophenyl-U-(Carbon 14)]-
Labelled NOA446510 Under Laboratory Conditions. Project Number:
T004618/02. Unpublished study prepared by Syngenta Crop Protection, Inc. 38
P-
46800013	Hand, L.; Towers, J. (2003) Aqueous Photolysis of (Carbon 14)-
Methyoxyphenyl-NOA446510 Under Laboratory Conditions: Final Report.
Project Number: 02JH091, T004630/02, RJ3395B. Unpublished study prepared
by Syngenta Jealotts Hill International. 85 p.
46800014	Murphy, T. (2006) Aqueous Photolysis of (Carbon 14)-Methyoxyphenyl-
NOA446510 Under Laboratory Conditions. Project Number: T004630/02.
Unpublished study prepared by Syngenta Crop Protection, Inc. 31 p.
46800015	Bramley, Y. (2005) NOA446510: Soil Photolysis of (Carbon 14)-Chlorophenyl
Ring Labelled NOA446510 Under Laboratory Conditions: Final Report. Project
Number: RJ3535B, T008105/03. Unpublished study prepared by Syngenta
Jealotts Hill International. 107 p.
46800016	Murphy, T. (2006) NOA446510: Soil Photolysis of (Carbon 14)-Methoxyphenyl
Ring Labelled NOA446510 Under Laboratory Conditions. Project Number:
T004595/02. Unpublished study prepared by Syngenta Crop Protection, Inc. 36
P-
46800017	Kuet, S. (2003) NOA446510: Soil Photolysis of (Carbon 14)-Methoxyphenyl
Ring Labelled NOA446510 Under Laboratory Conditions: Final Report. Project
Number: RJ3400B, T004595/02, 02JH095. Unpublished study prepared by

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21
Syngenta Jealotts Hill International. 96 p.
46800018	McKillican, C. (2005) Photodegradation of (Carbon 14)-NOA-446510 on Soil
Under Artificial Light: Final Report Amendment. Project Number: 737/02,
T000737/02. Unpublished study prepared by Syngenta Crop Protection, Inc.,
Agvise Inc. and North Dakota State University. 109 p.
46800019	Murphy, T. (2006) Photodegradation of (Carbon 14)-NOA-446510 on Soil
Under Artificial Light. Project Number: T000737/02. Unpublished study
prepared by Syngenta Crop Protection, Inc. 41 p.
46800020	Clark, A. (2004) Metabolism of [(Carbon 14)-Chlorophenyl]-NOA-446510 in
Viable Soil Under Aerobic Conditions: Final Report. Project Number: 680/02,
T000680/02. Unpublished study prepared by Syngenta Crop Protection, Inc.,
Agvise Inc. and North Dakota State University. 132 p.
46800021	Murphy, T. (2006) Metabolism of [(Carbon 14)-Chlorophenyl]-NOA446510 in
Viable Soil Under Aerobic Conditions. Project Number: T000680/02.
Unpublished study prepared by Syngenta Crop Protection, Inc. 50 p.
46800022	Nicollier, G. (2003) Metabolism of [Methyoxyphenyl-U-(Carbon 14)] Labelled
NOA446510 Under Aerobic, Aerobic/Anaerobic and Sterile Aerobic Laboratory
Conditions in One Soil at 20 degrees C: Final Report. Project Number: 02RF02,
T004633/02. Unpublished study prepared by Syngenta Crop Protection, AG. 85
P-
46800023	Berdat, T. (2005) Rate of Degradation of [(Carbon 14)] CGA380778
(Metabolite of NOA446510) in Various Soils Under Aerobic Laboratory
Conditions at 20 degrees C: Final Report. Project Number: T004943/04.
Unpublished study prepared by Syngenta Crop Protection, AG. 86 p.
46800024	Hand, L. (2004) NOA446510: Rate of Degradation in One Soil Under Various
Laboratory Conditions: Final Report. Project Number: RJ3487B, T008097/03.
Unpublished study prepared by Syngenta Jealotts Hill International. 123 p.
46800025	Murphy, T. (2006) NOA446510: Rate of Degradation in One Soil Under
Various Laboratory Conditions. Project Number: T008097/03. Unpublished
study prepared by Syngenta Crop Protection, Inc. 40 p.
46800026	Dorn, R.; Clark, A.; Perine, J.; et. al. (2006) Evaluation of Degradation Times
After Adjustment For Temperature and Moisture Effects of NOA446510 and its
Metabolite in Various Soils Under Laboratory Conditions. Project Number:
T014422/05, T004572/02, T004633/02. Unpublished study prepared by
Syngenta Crop Protection, Inc. 46 p.
46800027	Nicollier, G. (2003) Metabolism of [Chlorophenyl-U-(Carbon 14)] Labelled
NOA446510 Under Aerobic and Aerobic/Anaerobic Laboratory Conditions in
One Soil at 20 degrees C: Final Report. Project Number: 02TB03, T004572/02.

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22
Unpublished study prepared by Syngenta Crop Protection, AG. 95 p.
46800028	Kuet, S. (2004) NOA446510: Metabolism and Rate of Degradation of (Carbon
14)-Chlorophenyl Ring Labelled NOA446510 Under Aerobic Laboratory
Conditions, in Three Soils, at 20 degrees C: Final Report. Project Number:
RJ3469B, T008109/03, 03JH012. Unpublished study prepared by Syngenta
Jealotts Hill International and Natural Resource Management (NRM) LTD. 122
P-
46800029	Dorn, R. (2005) Evaluation of Half-Lives of Selected Metabolites of
NOA446510 in Aquatic Systems. Project Number: T001209/06, ASS05RD04.
Unpublished study prepared by Syngenta Crop Protection, Inc. 64 p.
46800030	Murphy, T. (2006) NOA446510: Degradation in Two Aquatic Sediment
Systems. Project Number: T008095/03. Unpublished study prepared by
Syngenta Crop Protection, Inc. 71 p.
46800031	Hurt, A. (2005) NOA446510: Degradation on Two Aquatic Sediment Systems:
Final Report. Project Number: RJ3669B, T008095/03, 03JH023. Unpublished
study prepared by Syngenta Jealotts Hill International and Natural Resource
Management (NRM) LTD. 145 p.
46800032	Oliver, R.; Webb, J.; Edwards, P. (2005) NOA446510: Degradation in an
Outdoor Aquatic Sediment System: Final Report. Project Number: RJ3569B,
T009117/04, 04JH007. Unpublished study prepared by Syngenta Jealotts Hill
International and Natural Resource Management (NRM) LTD. 164 p.
46800033	Hurt, A. (2005) NOA466510: Degradation in Two Aquatic Sediment Systems
(Methoxyphenyl Ring): Final Report. Project Number: RJ3580B, T008104/03,
03JH035. Unpublished study prepared by Syngenta Jealotts Hill International
and Natural Resource Management (NRM) LTD. 153 p.
46800034	Clark, A. (2006) NOA446510: Degradation on Two Aquatic Sediment Systems
(Methoxyphenyl Ring): Final Report. Project Number: T008104-03.
Unpublished study prepared by Syngenta Crop Protection, Inc. 33 p.
46800035	Indergand, P. (2005) Adsorption/Desorption of [Chlorophenyl-U-(Carbon 14)]-
Labelled SYN521195 in Various Soils: Final Report. Project Number:
T013384/04. Unpublished study prepared by Syngenta Crop Protection, AG. 83
P-
46800036	Hand, L.; Fleming, E. (2005) Adsorption/Desorption of a Metabolite
(SYN539678) in Three Soils: Final Report. Project Number: RJ3674B,
T013385/04, 05JH001. Unpublished study prepared by Syngenta Jealotts Hill
International. 73 p.
46800037	Nicollier, G.; Indergand, P. (2005) Adsorption/Desorption of [Methoxyphenyl-
U-(Carbon 14)]-Labelled NOA446510 in Various Soils (Including Final Report

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23
Amendment 1): Final Report. Project Number: 855434, T013634/04.
Unpublished study prepared by Syngenta Crop Protection, AG. 87 p.
46800038	Nicollier, G. (2005) Adsorption/Desorption of [Phenyl-U-(Carbon 14)]-Labelled
SYN500003 in Various SOils (Including Final Report Amendment 1): Final
Report. Project Number: 02TB04, T004577/02. Unpublished study prepared by:
Syngenta Crop Protection, AG. 87 p.
46800039	Murphy, T. (2006) Adsorption/Desorption of [Methoxyphenyl-U-(Carbon 14)]-
Labelled NOA446510 in Various Soils. Project Number: T004577/02.
Unpublished study prepared by Syngenta Crop Protection, Inc. 46 p.
46800040	Berdat, T.; Nicollier, G. (2006) NOA446510: Adsorption/Desorption of
[Methoxyphenyl-U-(Carbon 14)]-Labelled NOA446510 in Various US Field
Soils (Includes Final Report Amendment 1): Final Report. Project Number:
04TB01, T000738/02. Unpublished study prepared by Syngenta Crop
Protection, AG. 97 p.
46800041	Murphy, T. (2006) NOA446510: Adsorption/Desorption of [Methoxyphenyl-U-
(Carbon 14)]-Labelled NOA446510 in Various US Field Soils. Project Number:
T000738/02. Unpublished study prepared by Syngenta Crop Protection, Inc. 43
P-
46800042	Adam, D. (2004) Adsorption/Desorption of (Carbon 14)-CAG380778 on
Various Soils: Final Report. Project Number: 8558381, T004956/04.
Unpublished study prepared by RCC Umweltchemie Ag. 81 p.
46800043	Murphy, T. (2006) Adsorption/Desorption of (Carbon 14)-CGA380778 on
Various Soils. Project Number: T004956/04. Unpublished study prepared by
Syngenta Crop Protection, Inc. 47 p.
46800044	Harrison, C. (2005) NOA446510: Adsorption/Desorption Properties of a Water
Sediment Metabolite SYN504851 in Three Soils: Final Report. Project Number:
RJ3633B, T013383/04, 04JH028. Unpublished study prepared by Syngenta
Jealotts Hill International. 67 p.
46800045	Peters, J. (2005) Dissipation of NOA446510 250SC in Bare Soil Plot Under
Simulated Leafy Vegetable Production Conditions in the San Joaquin Valley of
California: Final Report. Project Number: T000052/03, ERS23039, 110/025.
Unpublished study prepared by Syngenta Crop Protection, Inc., Excel Research
Services, Inc. and North Coast Laboratories, Inc. 390 p.
46800046	Peters, J. (2005) Dissipation of NOA446510 250SC Under Field Conditions on
Crop (Potatoes) and Bare Soil in New York: Final Report. Project Number:
T000053/03, 05SYN150/REP, 242/68. Unpublished study prepared by Syngenta
Crop Protection, Inc., Waterborne Environmental, Inc. (WEI) and Enviro-Test
Laboratories (ETL). 407 p.

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24
46800047	Peters, J. (2005) Dissipation of NOA446510 250SC in a Bare Soil Plot Under
Simulated Squash Production Conditions in Georgia: Final Report. Project
Number: T000054/03, 242/69. Unpublished study prepared by Syngenta Crop
Protection, Inc., Waterborne Environmental, Inc. (WEI) and Ag Research
Associates. 327 p.
46800048	Peters, J.; Schwartz, B. (2005) Stability of NOA-446510 and CGA-380778 in
Soil Under Freezer Storage Conditions: Final Report. Project Number:
TOO 1672/03. Unpublished study prepared by Syngenta Crop Protection, Inc. and
Agvise Inc. 118 p.
46800049	Chen, W. (2006) Degradation of NOA446510 Influenced by Soil Temperature
Under Cropped and Bare Soil Conditions: A Conceptual Model Approach to
Bridge Data From Laboratory to Field: Final Report. Project Number:
T021955/04. Unpublished study prepared by Syngenta Crop Protection, Inc. 59
P-
46800050	Maynard, S.; Woodyer, J. (2004) NOA446510: Acute Toxicity to Water Fleas:
Final Report. Project Number: BL7871/B, T004988/04, 03/1369/D.
Unpublished study prepared by Astrazeneca Uk Ltd. 21 p.
46800051	Maynard, S.; Swarbrick, R. (2006) NOA446510 Metabolite (CGA380778):
Acute Toxicity to Water Fleas: Final Report. Project Number: BL7959/B,
T006603/04, 04/0237/C. Unpublished study prepared by Astrazeneca Uk Ltd.
22 p.
46800100	Syngenta Crop Protection, Inc. (2006) Submission of Environmental Fate,
Toxicity, Exposure, Risk and Residue Data in Support of the Application for
Registration of Mandipropamid and the Petition for Tolerance of
Mandipropamid for Use on Brassica Vegetables, Bulb Vegetables, Cucurbits,
Fruiting Vegetables, Grapes, Potatoes, Tomatoes, and Tuberous and Corm
Vegetables. Transmittal of 50 of 152 Studies.
46800101	Palmer, S.; Kendall, T.; Krueger, H. (2005) NOA446510: A 96-Hour Flow-
Through Shell Deposition Test with the Eastern Oyster (Crassostrea virginica):
Final Report. Project Number: 528A/139, 735/02. Unpublished study prepared
by Wildlife International, Ltd. 62 p.
46800102	Palmer, S.; Kendall, T.; Krueger, H. (2005) NOA446510: A 96-Hour Flow-
Through Acute Toxicity Test with the Saltwater Mysid (Americamysis bahia):
Final Report. Project Number: 528A/137, 733/02. Unpublished study prepared
by Wildlife International, Ltd. 61 p.
46800103	Palmer, S.; Kendall, T.; Krueger, H. (2005) NOA446510: A 96-Hour Flow-
THrough Acute Toxicity Test with the Sheepshead Minnow (Cyprinodon
variegatus): Final Report. Project Number: 528A/138, 734/02. Unpublished
study prepared by Wildlife International, Ltd. 61 p.

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25
46800104	Maynard, S.; Swarbrick, R. (2005) CGA380778 (Metabolite of NOA446510):
Acute Toxicity to Rainbow Trout (Oncorhynchus mykiss): Final Report. Project
Number: BL7958/B, T004941/04. Unpublished study prepared by Astrazeneca
Uk Ltd. 19 p.
46800105	Palmer, S.; Kendall, T.; Krueger, H. (2006) NOA446510: A 96-Hour Flow-
Through Acute Toxicity Test with the Fathead Minnow (Pimephales promelas):
Final Report. Project Number: 528A/146, T014080/05, 2034037. Unpublished
study prepared by Wildlife International, Ltd. 61 p.
46800106	Palmer, S.; Kendall, T.; Krueger, H. (2006) NOA446510: A 96-Hour Flow-
Through Acute Toxicity Test with the Rainbow Trout (Oncorhynchus mykiss):
Final Report. Project Number: 528A/147, T014079/05, 2034036. Unpublished
study prepared by Wildlife International, Ltd. 62 p.
46800107	Grade, R. (2003) Daphnia magna Reproduction Test: Effects of NOA 446510 on
the Reproduction of the Cladoceran Dapnia magna Straus in a Semi-Static
Laboratory Test: Final Report. Project Number: 2013604, T011821/05.
Unpublished study prepared by Syngenta Crop Protection, AG. 51 p.
46800108	Maynard, S. (2003) NOA446510 Tech: Early-Life Stage Toxicity Test to the
Fathead Minnow (Pimephales promelas): Final Report. Project Number:
BL7577/B, T011834/05. Unpublished study prepared by Astrazeneca Uk Ltd.
61 p.
46800109	Roberts, G.; Peurou, F. (2003) Determination of the Accumulation and
Elimination of (Carbon 14)NOA446510 in Fathead Minnow (Pimephales
promelas): Final Report. Project Number: BL7579/B, T011831/05. Unpublished
study prepared by Astrazeneca Uk Ltd. 47 p.
46800110	Gallagher, S.; Mitchell, L.; Beavers, J. (2002) NOA446510 (AMS): An Acute
Oral Toxicity Study with the Northern Bobwhite: Final Report. Project Number:
528/141, T011816/05. Unpublished study prepared by Wildlife International,
Ltd. 26 p.
46800111	Gallagher, S.; Beavers, J. (2005) NOA446510 (AMS): An Acute Oral Toxicity
Study with the Mallard: Final Report Amendment. Project Number: 528/142,
T011814/05. Unpublished study prepared by Wildlife International, Ltd. 29 p.
46800112	Gallagher, S.; Temple, D.; Beavers, J.; et. al. (2002) NOA446510 (AMS): A
Dietary LC50 Study with the Mallard: Final Report. Project Number: 528/140,
TO 11820/05. Unpublished study prepared by Wildlife International, Ltd. 52 p.
46800113	Gallagher, S.; Temple, D.; Beavers, J.; et. al. (2002) NOA446510 (AMS): A
Dietary LC50 Study with the Northern Bobwhite: Final Report. Project Number:
528/139, T011818/05. Unpublished study prepared by Wildlife International,
Ltd. 52 p.

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26
46800114	Frey, L.; Beavers, J.; Martin, K.; etal. (2003) NOA446510 (AMS): A
Reproduction Study with the Mallard: Final Report. Project Number: 528/150,
TO 11823/05. Unpublished study prepared by Wildlife International, Ltd. 154 p.
46800115	Frey, L.; Beavers, J.; Martin, K.; etal. (2003)NOA446510 (AMS): A
Reproduction Study with the Northern Bobwhite: Final Report. Project Number:
528/149, T011828/05. Unpublished study prepared by Wildlife International,
Ltd. 155 p.
46800116	Grimm, C. (2002) Acute Contact and Oral Toxicity of NOA446510 to Honey
Bees (Apis mellifera L.): Final Report. Project Number: 2013603, T011807/05.
Unpublished study prepared by Syngenta Crop Protection, AG. 63 p.
46800117	Porch, J.; Martin, K.; Krueger, H. (2005) NOA446510: A Glasshouse Toxicity
Study to Determine the Effects of a 250 g ai/Litre SC Formulation (A12946B)
on the Seedling Emergence of Ten Species of Plants: Final Report. Project
Number: 528/192, T004962/04. Unpublished study prepared by Wildlife
International, Ltd. 106 p.
46800118	Porch, J.; Krip, W.; Krueger, H. (2005) NOA446510: A Glasshouse Toxicity
Study to Determine the Effects of a 250 g ai/Litre SC Formulation (A12946B)
on the Vegatative Vigour of Ten Species of Plants: Final Report. Project
Number: 528/193, T013671/05. Unpublished study prepared by Wildlife
International, Ltd. 135 p.
46800119	Desjardins, D.; Kendall, T.; Krueger, H. (2006) NOA446510: A 7-Day Static-
Renewal Toxicity Test with the Duckweed (Lemna gibba G3): Final Report.
Project Number: 528A/148, T014081/05, 2034038. Unpublished study prepared
by Wildlife International, Ltd. 69 p.
46800120	Maynard, S.; Swarbrick, R. (2005) NOA446510 Metabolite (CGA380778):
Toxicity to the Green Alga Pseudokirchneriella subcapitata (Formerly
Selenastrum capricornutum): Final Report. Project Number: BL7960/B,
T006606/04. Unpublished study prepared by Astrazeneca Uk Ltd. 23 p.
46800121	Volz, E. (2005) Mandipropamid (NOA446510): Toxicity to Pseudokirchneriella
subcapitata (Formerly Selenastrum capricornutum) in a 96-Hour Algal Growth
Inhibition Test: Final Report. Project Number: A33175, T011224/05, 2034021.
Unpublished study prepared by RCC Umweltchemie Ag. 48 p.
46800122	Friedrich, S. (2004) CGA380778 (Metabolite of NOA446510): Acute Toxicity
to the Earthworm Eisenia fedita): Final Report. Project Number: 04/10/48/068,
T006608/04, 2033742. Unpublished study prepared by Biochem Agrar, Lab fuer
Biologische und Chemische. 23 p.
46800123	Friedrich, S. (2001) Acute Toxicity of NOA446510 to the Earthworm Eisenia
fetida: Final Report. Project Number: 01/10/48/060, T011804/05, 2013715.

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27
Unpublished study prepared by Biochem Agrar, Lab fuer Biologische und
Chemische. 42 p.
46800124	Kendall, T.; Nixon, W. (2005) Analytical Method Verification for the
Determination of NOA446510 in Saltwater: Final Report. Project Number:
528C/123, T003405/03, 3405/03. Unpublished study prepared by Wildlife
International, Ltd. 46 p.
46800125	Bruns, G.; Nelson, S. (2004) Independent Laboratory Validation: Syngenta:
"Analytical Method REM 202.02 for the Determination of NOA0446510 and its
Metabolite CGA-380788, in Soil, Using Liquid Chromatography-Electrospray
Ionization Tandem Mass Spectrometry (Including Validation Data)." Project
Number: 04ILV05SYN, 04SYN142/REP, T006443/04. Unpublished study
prepared by Enviro-Test Laboratories (ETL). 63 p.
46800126	Williams, R. (2003) Analytical Method REM 202.02 for the Determination of
NOA-446510 and its Metabolite CGA-3 80778, in Soil, Using Liquid
Chromatography-Electrospray Ionization Tandem Mass Spectrometry
(Including Validation Data). Project Number: T000056/03. Unpublished study
prepared by Syngenta Crop Protection, Inc. 41 p.
46800127	Chen, L. (2005) NOA446510: Metabolism in Lettuce: Final Report. Project
Number: RJ3470B, T004603/02, 03JH021. Unpublished study prepared by
Syngenta Jealotts Hill International. 87 p.
46800128	Cary, C. (2005) NOA446510: Metabolism in the Goat: Final Report. Project
Number: RJ3557B, T004579/02, 02JH021. Unpublished study prepared by
Syngenta Jealotts Hill International. 183 p.
46800129	Vollmin, S. (2003) Metabolism of [l-(Carbon 14)] NOA446510 in Field Grown
Tomato Plants (Including Final Report Amendment 1): Final Report. Project
Number: 01SV10, T008115/03. Unpublished study prepared by Syngenta Crop
Protection, AG. 123 p.
46800130	Sandmeier, P. (2003) Metabolism of [Methoxyphenyl-(U)-(Carbon 14)] and
[Chlorophenyl -(U)-(Carbon 14)] NOA446510 in Field Grown Grapevine
(Including Final Report Amendments 1, 2 and 3): Final Report. Project Number:
02SV11, T004623/02. Unpublished study prepared by Syngenta Crop
Protection, AG. 260 p.
46800131	Lister, N. (2006) NOA446510 - Metabolism in Potatoes: Summary. Project
Number: T001139/06, T004211/05, RJ3564B. Unpublished study prepared by
Syngenta Crop Protection, AG and Syngenta Jealotts Hill International. 258 p.
46800132	Gill, J. (2004) NOA446510: Validation of Residue Analytical Method RAM
415/01 for the Determination of Residue on Crops. Project Number:
T004213/05, RJ3542B, 03/S607. Unpublished study prepared by Syngenta

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28
Jealotts Hill International. 70 p.
46800133	Perez, R.; Perez, S. (2006) Independent Laboratory Validation: Syngenta:
"Analytical Method RAM 415/01 Residue Analytical Method for the
Determination of NOA446510 in Crop Samples. Final Determination by LC-
MS/MS": Final Amended Report. Project Number:
ADPEN/901/2K5/T010236/04, T010236/04, 415/01. Unpublished study
prepared by Adpen Labs. 81 p.
46800134	Lin, K. (2005) Determination of NOA-446510 by the U.S. Food and Drug
Administration Multiresidue Methods: Final Report. Project Number:
T003473/05. Unpublished study prepared by Syngenta Crop Protection, Inc. 30
P-
46800135	Joseph, T. (2006) Determination of NOA-446510 by the U.S. Food and Drug
Administration Multiresidue Methods. Project Number: T003473/05.
Unpublished study prepared by Syngenta Crop Protection, Inc. 7 p.
46800136	Hamilton, L. (2005) Residue Stability of NOA-446510 Fortified into Crop
Commodities Under Freezer Storage Conditions: Interim Report. Project
Number: T006170/04, 6170/04. Unpublished study prepared by Syngenta Crop
Protection, Inc. 90 p.
46800137	Joseph, T. (2005) NOA446510 - Magnitude of the Residues in or on Grapes,
Including Processed Commodities. Project Number: T000208/03,
EB/FR/002/03, EE/FR/001/03. Unpublished study prepared by Syngenta Crop
Protection, Inc., Crop Management Strategies, Inc. and A.C.D.S. Research, Inc.
238 p.
46800138	Joseph, T.; Hamilton, L. (2005) NOA446510 - Magnitude of the Residues in or
on Vegetables, Bulb, Group 3: Final Report. Project Number: T000283/03,
SI/FR/04/5360, SA/FR/04/5361. Unpublished study prepared by Syngenta Crop
Protection, Inc, Southeast Ag Research, Inc. and South Texas Ag Research, Inc.
149 p.
46800139	Joseph, T.; Hamilton, L. (2005) NOA446510 - Magnitude of the Residues in or
on Crop Subgroup 1C: Tuberous and Corm Vegetables, Including Processed
Commodities: Final Report. Project Number: T000011/03, E5/FR/001/03,
EF/FR/001/03. Unpublished study prepared by Syngenta Crop Protection, Inc.,
Syngenta Crop Protection and Agricultural Chemical Development Services,
Inc. 203 p.
46800140	Joseph, T.; Hamilton, L. (2005) NOA-446510 - Magnitude of the Residues of
NOA-446510 in or on Cantaloupe, Cucumber, and Squash as Representative
Commodities of Crop Group 9: Cucurbit Vegetables: Final Report. Project
Number: T0000015/03, SI/FR/04/5335, SJ/FR/04/5336. Unpublished study
prepared by Syngenta Crop Protection, Inc., Ag Research Associates and

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29
Agricultural Systems Associates. 162 p.
46800141	Joseph, T.; Hamilton, L. (2005) NOA-446510 - Magnitude of the Residues in or
on Vegetables, Brassica, Group 5: Final Report. Project Number: T000013/03,
SA/FR/04/5315, WC/FR/04/5316. Unpublished study prepared by Syngenta
Crop Protection, Inc., BASF and Syngenta Crop Protection. 202 p.
46800142	Joseph, T.; Hamilton, L. (2005) NOA - Magnitude of the Residues in or on Crop
Group 8: Fruiting Vegetables, Including Processed Commodities: Final Report.
Project Number: T000012/03, 2A/FR/04/5621, E5/FR/002/03. Unpublished
study prepared by Syngenta Crop Protection, Inc.,Syngenta Crop Protection and
Syngenta Crop Protection. 273 p.
46800143	Lister, N. (2006) NOA446510 - Summary of EU Supervised Field Trials
Residue Data on Tomatoes. Project Number: T012551/05, 03/6009, 03/6007.
Unpublished study prepared by Syngenta Jealotts Hill International. 420 p.
46800144	Lister, N. (2006) NOA446510 - Summary of EU Supervised Field Trials
Residue Data on Grapes. Project Number: T012550/05, 03/6059, 03/6062.
Unpublished study prepared by Syngenta Jealotts Hill International. 422 p.
46800145	Stingelin, J. (2004) Outdoor Confined Accumulation Study on Rotational Crops
after Bareground Application of [Chlorophenyl-(U)-(Carbon 14)] NOA446510
(Including Final Report Amendments 1 and 2): Final Report. Project Number:
T004608/02, 02JS39. Unpublished study prepared by Syngenta Crop Protection,
AG. 131 p.
46800146	Stingelin, J. (2004) Outdoor Confined Accumulation Study on Rotational Crops
after Bareground Application of [Methoxyphenyl-(U)-(Carbon 14)]
NOA446510 (Includes Final Report Amendments 1 and 2): Final Report.
Project Number: 02JS40, T004212/05. Unpublished study prepared by Syngenta
Crop Protection, AG. 130 p.
46800147	Grout, S. (2005) NOA446510: Outdoor Confined Accumulation Study on
Rotational Crops after Bareground Application of (Carbon 14)-NOA446510:
Additional Work on Non-Extractable Residues. Project Number: RJ3702B,
T016317/04, 04JH023. Unpublished study prepared by Syngenta Jealotts Hill
International. 84 p.
46800148	Lister, N. (2006) NOA446510 - Confined Accumulation in Rotational Crops.
Project Number: T001140/06. Unpublished study prepared by Syngenta Jealotts
Hill International and Syngenta Crop Protection, AG. 26 p.
46800149	Joseph, T.; Hamilton, L. (2005) NOA-446510 - Field Accumulation in
Rotational Crops (30-Day and 60-Day PBIs): Final Report. Project Number:
T000843/03, 5A/FR/04/5690, 4A/FR/04/5692. Unpublished study prepared by
Syngenta Crop Protection, Inc., Syngenta Crop Protection and Northern

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30
Regional Technical Center. 108 p.
46800150 Moore, G. (2004) Acute Oral Toxicity Up and Down Procedure in Rats:
NOA446510 SC (250): Final Report. Project Number: 14708, T003556/03,
P320/UDP. Unpublished study prepared by Product Safety Laboratories. 14 p.
46800200	Syngenta Crop Protection (2006) Submission of Toxicity, Fate, Exposure and
Risk Data in Support of the Application for Registration of Mandy and the
Petition for Tolerance of Madipropamid in Brassica Vegetables, Bulb
Vegetables, Cucurbits, Fruiting Vegetables, Grapes, Potatoes, Tomatoes, and
Tuberous and Corm Vegetables. Transmittal of 52 of 152 Studies.
46800201	Moore, G. (2004) Acute Oral Toxicity Up and Down Procedure in Rats:
NOA446510 Tech.: Final Report. Project Number: P320/UDP, 14702,
T003555/03. Unpublished study prepared by Product Safety Laboratories. 15 p.
46800202	Kuhn, J. (2005) NOA 446510 Technical (Batch SEZ2BP007): Acute Dermal
Toxicity Study in Rats: Final Report. Project Number: 9169/05, T003767/05.
Unpublished study prepared by Stillmeadow, Inc. lip.
46800203	Johnson, I. (2004) NOA446510 250G/L SC (A12946B): Acute Dermal Toxicity
Study in the Rat: Final Report. Project Number: T008173/03,
58/REGULATORY/REPORT, CR3658. Unpublished study prepared by Central
Toxicology Lab. (Syngenta). 41 p.
46800204	Kilgour, J. (2003) NOA446510: 4-Hour Acute Inhalation Toxicity Study in Rats
(EPA and OECD): Final Report. Project Number:
10/REGULATORY/REPORT, T004626/02, HR2410. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 62 p.
46800205	Noakes, J. (2005) NOA446510 SC 250 (A12946B): 4-Hour Acute Inhalation
Toxicity Study in Rats: Final Report. Project Number:
58/REGULATORY/REPORT, T008167/03. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 59 p.
46800206	Johnson, I. (2004) NOA446510: Eye Irritation Study in the Rabbit: Final
Report. Project Number: 31/REGULATORY/REPORT, T001401/99.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 35 p.
46800207	Johnson, I. (2004) NOA446510 250G/L SC (A12946B): Eye Irritation Study in
the Rabbit: Final Report. Project Number: 78/REGULATORY/REPORT,
T008166/03. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 35 p.
46800208	Johnson, I. (2004) NOA446510: Skin Irritation Study in the Rabbit: Final
Report. Project Number: 53/REGULATORY/REPORT, T001400/99.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 25 p.

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31
46800209	Johnson, I. (2004) NOA446510 250g/l SC (A12946B): Skin Irritation Study in
the Rabbit: Final Report. Project Number: 75/REGULATORY/REPORT,
T008174/03. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 24 p.
46800210	Johnson, I. (2004) NOA446510: Skin Sensitisation Study in the Guinea Pig:
Final Report. Project Number: 62/REGUL AT OR Y/REPORT, T001397/99.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 35 p.
46800211	Ott, M. (2004) NOA446510 250 g/1 SC (A12946B): Contact Hypersensitivity in
Albino Guinea Pigs, Buhler Test (9-Induction): Final Report. Project Number:
852912, T001468/06. Unpublished study prepared by RCC Ltd. 56 p.
46800212	Johnson, I. (2005) NOA446510: Local Lymph Node Assay: Final Report.
Project Number: GULATORY/REVISION/R1, T004638/02. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 22 p.
46800213	Milburn, G. (2005) NOA446510: 90-Day Dietary Toxicity Study in the Mouse:
Final Report. Project Number: 6 5/REGUL AT OR Y/REPORT, T004588/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 398 p.
46800214	Pinto, P. (2005) NOA446510: 28-Day Dietary Range Finding Study in Rats:
Final Report. Project Number: AL/TOXICOLOGY/REPORT, T005177/01.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 236 p.
46800215	O'Connor, G. (2002) NOA446510: Development and Validation of
Methodology for the Analysis of NOA446510 in Diet, Including Stability
Assessment: Final Report. Project Number: 41/REGULATORY/REPORT,
T005174/01. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 43 p.
46800216	Pinto, P. (2005) NOA446510: 90 Day Dietary Toxicity Study in Rats: Final
Report. Project Number: PR1263/REG/R1, T004583/02. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 885 p.
46800217	Milburn, G. (2005) NOA446510: 28 Day Dietary Range Finding Study in Mice:
Final Report. Project Number: AL/TOXICOLOGY/REPORT, T005180/01.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 213 p.
46800218	Brammer, A. (2005) NOA446510: 90 Day Oral Toxicity Study in Dogs: Final
Report. Project Number: 72/REGULATORY/REPORT, T004586/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 467 p.
46800219	Brammer, A. (2005) NOA446510: 6 Week Preliminary Oral Toxicity Study in
Dogs: Final Report. Project Number: AL/TOXICOLOGY/REPORT,
T004600/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 116 p.

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32
46800220	Brammer, A. (2005) NOA446510: Preliminary Oral Toxicity Study: Final
Report. Project Number: AL/TOXICOLOGY/REPORT, T005184/01.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 103 p.
46800221	Lees, D. (2005) NOA446510: Dose Range Finding Study in the Rat (for a 28
Day Dermal Toxicity Study): Final Report. Project Number:
AL/TOXICOLOGY/REPORT, T008147/03. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 46 p.
46800222	Lees, D. (2005) NOA446510: 28 Day Dermal Toxicity Study in Rats: Final
Report. Project Number: 96/REGULATORY/REPORT, T004582/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 888 p.
46800223	Moxon, M. (2005) NOA446510: Dose Range Finding Study in the Pregnant
Rat: Final Report. Project Number: AL/TOXICOLOGY/REPORT, T004641/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 169 p.
46800224	Moxon, M. (2005) NOA446510: Prenatal Developmental Toxicity Study in the
Rat: Final Report. Project Number: 63 /REGUL AT OR Y/REPORT, T004598/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 453 p.
46800225	Moxon, M. (2005) NOA446510: Dose Range Finding Study in the Pregnant
Rabbit: Final Report. Project Number: AL/TOXICOLOGY/REPORT,
T004637/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 277 p.
46800226	Moxon, M. (2005) NOA446510: Dose Range Finding Study in Non-Pregnant
Rabbits: Final Report. Project Number: AL/TOXICOLOGY/REPORT,
T004624/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 25 p.
46800227	Moxon, M. (2005) NOA446510: Prenatal Developmental Toxicity Study in the
Rabbit: Final Report. Project Number: 62/REGULATORY/REPORT,
T004609/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 498 p.
46800228	Altmann, B. (2001) NOA446510: Rangefinding Prenatal Developmental
Toxicity Study in the Rat: Final Report. Project Number: 20013009,
T001467/06. Unpublished study prepared by Syngenta Crop Protection, Inc. 240
P-
46800229	Burns, A. (2005) NOA446510: Investigation of Tray Paper Staining Observed
in NOA446510 Rabbit Developmental Toxicity Studies. Project Number:
B7429/SUMMARY/REPORT, TO 17067/04. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 39 p.
46800230	Milburn, G. (2005) NOA446510: Multigeneration Reproduction Toxicity Study
in Rats: Final Report. Project Number: RR0990/REG, T005169/01. Unpublished

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33
study prepared by Central Toxicology Lab. (Syngenta). 3669 p.
46800231	Lees, D. (2005) NOA446510: Preliminary One Generation Reproduction Study
in Rats: Final Report. Project Number: RR0964, T004587/02. Unpublished
study prepared by Central Toxicology Lab. (Syngenta). 1001 p.
46800232	Brammer, A. (2005) NOA4466510: ! Year Oral Toxicity Study in Dogs: Final
Report. Project Number: PD1273/REG, T004622/02. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 506 p.
46800233	Milburn, G. (2005) NOA446510: 80 Week Carcinogenicity Study in Mice: Final
Report. Project Number: 75/REGULATORY/REPORT, T004628/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 1866 p.
46800234	Pinto, P. (2005) NOA446510: Two Year Chronic Toxicity and Carcinogenicity
Study in Rat: Final Report. Project Number: CTL/PR1274/REG, T004616/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 3595 p.
46800235	Callander, R. (2005) NOA446510: Bacterial Mutation Assay in S. Typherium
and E.Coli: Final Report. Project Number: ULATORY/REVISION/OOl,
T004610/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 34 p.
46800236	Clay, P. (2005) NOA446510: L5178y TK+/- Mouse Lymphoma Mutation
Assay: Final Report. Project Number: ULATORY/REVISION/OOl,
T004606/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 38 p.
46800237	Fox, V. (2002) NOA446510: In Vitro Cytogenic Assay in Human Lymphocytes:
Final Report. Project Number: 44/REGUL AT OR Y/REPORT, T004601/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 35 p.
46800238	Fox, V. (2005) NOA446510: Rat Bone Marrow Micronucleus: Final Report.
Project Number: 7 6/REGUL AT ORY/REPORT, T004631/02. Unpublished
study prepared by Central Toxicology Lab. (Syngenta). 29 p.
46800239	Clay, P. (2005) NOA446510: In Vivo Rat Liver Unscheduled DNA Synthesis
Assay: Final Report. Project Number: 93/REGULATORY/REPORT,
T004573/02. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 30 p.
46800240	Pinto, P. (2005) NOA446510: Subchronic Neurotoxicity Study in Rats: Final
Report. Project Number: 94/REGULATORY/REPORT, T008126/03.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 751 p.
46800241	Chivers, S. (2003) NOA446510: Preliminary Acute Neurotoxicity Study in Rats.
Project Number: AL/TOXICOLOGY/REPORT, T004596/02. Unpublished
study prepared by Central Toxicology Lab. (Syngenta). 34 p.

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34
46800242	Milburn, G. (2005) NOA446510: Acute Neurotoxicity Study in Rats: Final
Report. Project Number: 52/REGULATORY/REPORT, T008108/03.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 648 p.
46800243	Roberts, K. (2005) NOAA446510: Tissue Depletion Following a Single Oral
Dose (3 mg/kg) in the Rat: Final Report. Project Number:
61/REGULATORY/REPORT, T004639/02. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 83 p.
46800244	Wake, A. (2005) NOA446510: Biotransformation in the Rat: Final Report.
Project Number: 58/REGULATORY/REPORT, T001396/99. Unpublished
study prepared by Central Toxicology Lab. (Syngenta). 97 p.
46800245	Silcock, R.; Duerden, A. (2005) NOA446510: Absorption, Distribution and
Excretion in the Rat: Final Report. Project Number:
19/REGULATORY/REPORT, T004576/02. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 84 p.
46800246	Roberts, K. (2005) NOA446510: Tissue Accumulation and Depletion Following
Multiple Oral Dosing (3 mg/kg) in the Rat: Final Report. Project Number:
8 6/REGUL AT OR Y/REPORT, T004612/02. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 51 p.
46800247	Hadfield, N. (2003) NOA446510: Comparative In Vitro Dermal Penetration
Through Rat Epidermis of Two 250 g/1 SC Formulations (A12946C and
A12946B). Project Number: AL/TOXICOLOGY/REPORT, T008170/03.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 32 p.
46800248	Silcock, R. (2005) NOA446510: NOA446510 250 g/1 SC Formulation
(A12946B): In Vivo Dermal Absorption Study in Rat: Final Report. Project
Number: 41/REGULATORY/REPORT, T004954/04. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 59 p.
46800249	Davies, D. (2003) NOA446510: In Vitro Absorption Through Pig Epidermis:
Final Report. Project Number: 33/TOXICOLOGY/REPORT, T004643/02.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 27 p.
46800250	Davies, D. (2005) NOA446510 250g/l SC Formulation (A12946B): In Vitro
Dermal Absorption of NOA4465510 Through Human Epidermis: Final Report.
Project Number: JV1824/REVISION/001, T004621/02. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 41 p.
46800251	Davies, D. (2005) NOA446510 250g/l SC Formulation (A12946B): In Vitro
Dermal Absorption of NOA446510 Through Rat Epidermis: Final Report.
Project Number: T004625/02. Unpublished study prepared by Central
Toxicology Lab. (Syngenta). 38 p.
46800252
Perine, J. (2006) Mandipropamid (NOA446510): Drinking Water Exposure

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35
Assessment for Mandipropamid (NOA446510) on Fruiting Vegetables, Bulb
Vegetables, Brassica Vegetables, Grapes, Cucurbits, and Potatoes. Project
Number: T021954/04. Unpublished study prepared by Syngenta Crop
Protection, Inc. 16 p.
46953700	Syngenta Crop Protection, Inc. (2006) Submission of Toxicity Data in Support
of the Registration of Mandy. Transmittal of 17 Studies.
46953701	Hamilton, L.; Jospeh, T. (2006) Residue Stability of NOA446510 Fortified into
Crop Commodities Under Freezer Storage Conditions: Final Report. Project
Number: T006170/04. Unpublished study prepared by Syngenta Crop
Protection, Inc. 128 p.
46953702	Joseph, T.; Hamilton, L. (2006) Magnitude of the Residues in or on Crop
Subgroup 1C, Tuberous and Corm Vegetables Including Processed
Commodities: Amended Final Report (Replaces MRID Number 46800139).
Project Number: T000011/03, NL/FR/001/03. Unpublished study prepared by
Syngenta Crop Protection, Inc., Agricultural Chemical Development Services,
Inc. and Warnke Research Services. 291 p.
46953703	Lister, N. (2006) Summary of EU Supervised Field Trials Residue Data on
Grapes: NOA446510: (Final Report). Project Number: T002345/06, 03/6062,
03/6061. Unpublished study prepared by Jealott's Hill Res. Station. 422 p.
46953704	Pooles, A. (2006) Acute Oral Toxicity in the Rat - Up and Down Procedure:
SYN 500003 (Metabolite of NOA446510): Final Report. Project Number:
0006/0737, T006762/04. Unpublished study prepared by Safepharm
Laboratories Ltd. 19 p.
46953707	Dow, J. (2006) NOA446510: Effects on the Liver Following Dietary
Administration in the Mouse: Final Report. Project Number: 026543,
T001723/06. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 68 p.
46953708	Dow, J. (2006) NOA446510: Effects on the Liver Following Dietary
Administration in the Rat: Final Report. Project Number: 026544, T008129/03.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 117 p.
46953709	Lees, D. (2006) Mandipropamid: Investigation of Cell Proliferation in the Liver
in Female Rats: Final Report. Project Number: XR7561/TEC, T001830/06.
Unpublished study prepared by Central Toxicology Lab. (Syngenta). 164 p.
46953710	Bachman, M. (2001) NOA446510 Tech: 28-Day Exploratory Toxicity Study in
Rats (Gavage): Final Report. Project Number: 20013008, T002342/06.
Unpublished study prepared by Syngenta Crop Protection. 32 p.
46953711	Callander, R. (2006) SYN 500003 (Metabolite of NOA446510) Bacterial
Mutation Assay in S. typhimurium and E. coli: Final Report. Project Number:

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36
YV7195/REG, T003954/05. Unpublished study prepared by Central Toxicology
Lab. (Syngenta). 31 p.
46953712	Callander, R. (2006) SYN545038 (Impurity of Mandipropamid) Bacterial
Mutation Assay in S. typhimurium and E. coli: Final Report. Project Number:
YV7241/REG, T013670/05. Unpublished study prepared by Central Toxicology
Lab. (Syngenta). 30 p.
46953713	Booth, E., Roberts, K. (2006) NOA446510: Programme to Investigate Dose
Versus Oral Absorption/Systemic Exposure Relationship in Mice: Assessment.
Project Number: CTL/024843, T001806/06. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 80 p.
46953714	Pinto, P. (2006) NOA446510: Acute High Dose Study in Rats: Final Report.
Project Number: AR7329/TEC, T008143/03. Unpublished study prepared by
Central Toxicology Lab. (Syngenta). 220 p.
46953715	Pinto, P. (2006) NOA446510: Acute High Dose Study in the Mouse: Final
Reprt. Project Number: AM7330/TEC, T008144/03. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 215 p.
46953716	Wake, A. (2006) NOA446510: Preliminary Metabolism and Bioavailability in
the Dog: Final Report. Project Number: UD0763, T0064644/02,
CTL/UD0763/TEC/REPT. Unpublished study prepared by Central Toxicology
Lab. (Syngenta). 85 p.
46953717	Roberts, K. (2006) NOA446510: Investigative Metabolism in the Rat: Final
Report. Project Number: CTL/UR0717, T004636/02. Unpublished study
prepared by Central Toxicology Lab. (Syngenta). 107 p.
47061000	Syngenta Crop Protection, Inc. (2007) Submission of Product Chemistry and
Toxicity Data in Support of the Application for Registration of Revus Opti.
Transmittal of 8 Studies.
47061001	Irrig, H. (2006) Manufacturing Process Description and Supporting Data for
Mandipropamid/Chlorothalonil SC (3.3/33.3) (A13985A). Project Number:
PC/06/117. Unpublished study prepared by Syngenta Crop Protection, Inc. 319
P-
47061002	Irrig, H. (2006) Physical and Chemical Properties of
Mandipropamid/Chlorothalonil SC (3.3/33.3) (A13985A). Project Number:
PC/06/118, 114996, 10084279. Unpublished study prepared by Syngenta Crop
Protection, Inc, Custom Seed Treatment Blendi. 112 p.
47061003	Merkel, D. (2004) NOA 446510/Chlorothalonil SC (040/400) (A-13985A):
Acute Oral Toxicity Up and Down Procedure in Rats: Final Report. Project
Number: 14728, T003560/03, P320. Unpublished study prepared by Product
Safety Laboratories. 17 p.

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37
47061004	Johnson, I. (2004) NOA 446510/Chlorothalonil 40/400G/L SC (A-13985A):
Acute Dermal Toxicity Study in the Rat: Final Report. Project Number:
CR/2660, T008221/03. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 38 p.
47061005	Rattray, N. (2004) NOA446510/Chlorothalonil 40/400 G/L SC Formulation
(A13985A): 4-Hour Acute Inhalation Toxicity Study in Rats: Final Report.
Project Number: HR2472, T008222/03. Unpublished study prepared by Central
Toxicology Lab. (Syngenta). 61 p.
47061006	Johnson, I. (2004) NOA 446510/Chlorothalonil 40/400g/ 1 SC (A-13985A): Eye
Irritation Study in the Rabbit: Final Report. Project Number: FB6091,
T008219/03. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 33 p.
47061007	Johnson, I. (2004) NOA 446510/Chlorothalonil 40/400g/l SC (A-13985A:)
Skin Irritation Study in the Rabbit: Final Report. Project Number: EB5077,
T008223/03. Unpublished study prepared by Central Toxicology Lab.
(Syngenta). 22 p.
47061008	Arcelin, G. (2005) NOA446510/Chlorothalonil 40/400 g/1 SC (A13985A):
Contact Hypersensitivity in Albino Guinea Pigs, Buhler Test (9-Induction).
Project Number: 851650, T008220/03. Unpublished study prepared by RCC
Ltd. 57 p.
47061200	Syngenta Crop Protection, Inc. (2007) Submission of Product Chemistry and
Toxicity Data in Support of the Application for Registration of Revus Top.
Transmittal of 7 Studies.
47061201	Irrig, H. (2006) Manufacturing Process Description and Supporting Data for
Mandipropamid/Difenoconazole SC (21.9/21.9) (A14576A). Project Number:
PC/06/128, SF/66/1. Unpublished study prepared by Syngenta Crop Protection.
250 p.
47061202	Irrig, H. (2006) Physical and Chemical Properties of
Mandipropamid/Difenoconazole SC (21.9/21.9) (A14576A). Project Number:
PC/06/129, 116315, 116344. Unpublished study prepared by Syngenta Crop
Protection. 86 p.
47061203	Ott, M. (2006) Difenoconazole/Mandipropamid (250/250) SC (A14576A):
Acute Oral Toxicity Study in the Rat (Up and Down Procedure): Final Report.
Project Number: A71043, T014431/04. Unpublished study prepared by RCC
Ltd. 22 p.
47061204	Ott, M. (2006) Difenoconazole/Mandipropamid (250/250) SC (A14576A):
Acute Dermal Toxicity Study in Rats: Final Report. Project Number: A71054,
T014432/04. Unpublished study prepared by RCC Ltd. 21 p.

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38
47061205	Ott, M. (2006) Difenoconazole/Mandipropamid (250/250) SC (A14576A):
Primary Eye Irritation Study in Rabbits: Final Report. Project Number: A71076,
T014434/04. Unpublished study prepared by RCC Ltd. 31 p.
47061206	Ott, M. (2006) Difenoconazole/Mandipropamid (250/250) SC (A14576A):
Primary Skin Irritation Study in Rabbits (4-Hour Semi-Occlusive Application):
Final Report. Project Number: A71065, T014433/04. Unpublished study
prepared by RCC Ltd. 28 p.
47061207	Sattler, K. (2006) Difenoconazole/Mandipropamid (250/250) SC (A14576A):
Skin Sensitisation Study (Nine Induction Dose Buehler Test): Final Report.
Project Number: ARC/L/2108, T014435/04. Unpublished study prepared by
Austrian Research Center (ARC). 34 p.
47061900	Syngenta Crop Protection, Inc. (2007) Submission of Toxicity, Residue,
Efficacy, and Reduced Risk Data in Support of the Application for Registration
of Mandy and the Petition for Tolerance of Mandipropamid for Use on Leafy
Vegetables. Transmittal of 3 Studies.
47061901	Desjardins, D.; Kendall, T.; Krueger, H. (2006) NOA446510: A 7-Day Static-
Renewal Toxicity Test with Duckweed (Lemna gibba G3): Final Report. Project
Number: 528A/149, T001816/06, 528/032306/LEM7/OECD/OPPTS/100P618.
Unpublished study prepared by Wildlife International, Ltd. 67 p.
47061902	Joseph, T.; Hamilton, L. (2007) NOA446510 - Magnitude of the Residues in or
on Vegetables, Leafy, Group 4: Final Report. Project Number: T000014/03.
Unpublished study prepared by Syngenta Crop Protection. 265 p.
47061903	Rezaaiyan, R. (2007) Mandipropamid (Mandy): Reduced-Risk Pesticide
Rationale for Proposed Uses on Leafy Vegetables. Project Number:
T003525/05. Unpublished study prepared by Syngenta Crop Protection, Inc. 25
P-
47067800	Syngenta Crop Protection, Inc. (2007) Submission of Toxicity Data in Support
of the Application for Registration of Revus Top. Transmittal of 1 Study.
47067801	Shaw, D.; Rattray, N. (2006) Mandipropamid/Difenoconazole SC (250/250)
(A14576A): Acute Inhalation Study in Rats: Final Report. Project Number:
HR2547/REG/R1, T014436/04. Unpublished study prepared by Syngenta. 53 p.
47129300	Syngenta (2007) Submission of Product Chemistry Data in Support of the
Registration of Mandipropamid Technical. Transmittal of 1 Study.
47129301	Irrig, H. (2007) Manufacturing Process Description and Supporting Data for
Mandipropamid Technical. Project Number: PC/07/050. Unpublished study
prepared by Syngenta Crop Protection Inc. 55 p.
47217300
Syngenta Crop Protection, Inc. (2007) Submission of Residue Data in Support

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39
of the Application for Registration of Mandipropamid Technical. Transmittal of
2 Studies.
47217301	Klimmek, S. (2004) Mandipropamid: Analytical Method Developement and
Validation (S-19) for the Determination of Residues of NOA446510 in/on Plant
Matrices: Final Report. Project Number: IF/04/00160626, T004957/04.
Unpublished study prepared by Fresenius Ag. 37 p.
47217302	Lakaschus, S. (2005) Mandipropamid: ILV for the Determination of Residue of
Mandipropamid (NOA446510) in Tomato and Wheat Grain by Multi-Residue
Method S 19 (L 00.00-34) Validated by a Third Party Laboratory: Final Report.
Project Number: SYN/0423V, T004977/04. Unpublished study prepared by Dr.
Specht and Partner. 41 p.
47224500	Syngenta Crop Protection, Inc. (2007) Submission of Product Chemistry Data in
Support of the Application for Registration of Revus Fungicide. Transmittal of 1
Study.
47224501	Irrig, H. (2007) One-Year Storage Stability at Ambient Temperature and
Corrosion Characteristics of Mandipropamid SC (A12946B): Revus Fungicide.
Project Number: PC/07/068, 114137, 114184. Unpublished study prepared by
Syngenta Crop Protection, Inc. 126 p.
47259000	Syngenta Crop Protection, Inc. (2007) Submission of Toxicity Data in Support
of the Application for Registration of Mandy. Transmittal of 1 Study.
47259001	Kuhn, J. (2007) Mandipropamid Technical (SEZ3BP004) - Skin Sensitization:
Local Lymph Node Assay in Mice: Final Report. Project Number: 11116/07,
T003750/07. Unpublished study prepared by Stillmeadow, Inc. 12 p.

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