Policy Assessment for the Review of the Ozone National Ambient Air Quality Standards Errata December 10, 2020

Policy Assessment for the Review of the Ozone National Ambient Air Quality Standards
[EPA-452/R-20-001]
May 2020
Errata - December 10, 2020
1. In Chapter 1, the following citation for the 2013 ISA was inadvertently omitted:
U.S. EPA (2013). Integrated Science Assessment of Ozone and Related Photochemical
Oxidants (Final Report). Office of Research and Development, National Center for
Environmental Assessment. Research Triangle Park, NC. U.S. EPA. EPA-600/R-10-
076F. February 2013. Available at:
https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P100KETF.txt.
2. In Chapter 3, the following citations were inadvertantly omitted from the References
section:
Kousha, T and Rowe, BH (2014). Ambient ozone and emergency department visits due to
lower respiratory condition. Int J Occup Med Environ Health 27(1): 50-59.
Villeneuve, PJ, Chen, L, Rowe, BH and Coates, F (2007). Outdoor air pollution and
emergency department visits for asthma among children and adults: A case-crossover
study in northern Alberta, Canada. Environ Health 6: 40.
3. In Chapter 3, page 4-41 includes a reference to U.S. EPA 2018 which should be removed,
as should the following citation from the References section:
U.S. EPA (2018). Integrated science assessment for oxides of nitrogen, oxides of sulfur
and particulate matter -Ecological criteria (2nd external review draft). EPA/600/R-18/097.
U.S. Environmental Protection Agency, Office of Research and Development, National
Center for Environmental Assessment. Research Triangle Park, NC.
http://cfint.rtpnc. epa.gov/ncea/prod/recordisplay. cfm?deid=340671.
4. Chapter 3, page 3-55 includes a typographical error in reference to U.S. EPA 2010b,
which should instead be a reference to U.S. EPA 2010a. The following citation was
inadvertently included in the References section and should be removed:
U.S. EPA (2010b). Quantitative Health Risk Assessment for Particulate Matter (Second
External Review Draft). Office of Air Quality Planning and Standards, Health and
Environmental Impacts Division. Research Triangle Park, NC. U.S. EPA. EPA-452/P-10-
001 February 2010. Available at:
https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P1006EST.txt
5. In Chapter 3, page 3-81 includes a typographical error in reference to DHEW, 1969,
which should instead read "U.S. DHEW, 1970". The following citation was inadvertently
included and should be removed from the Chapter 3 References section:

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DHEW (1969). Air Quality Criteria for Particulate Matter. National Air Pollution Control
Administration. Washington, D.C. U.S. Department of Health. January 1969.
6. Chapter 3, Table 3-2 includes the phrase "See Appendix 3A" that should be "See
Appendix 3 A D." The corrected table appears below.
Table 3-2 Summary of 6.6-hour controlled human exposure study-findings, healthy adults.
Endpoint
O3 Target
Exposure
Concentration*
Statistically
Significant
EffectB
03-lnduced Group
Mean Response B
Study
FEVi
Reduction
120 ppb
Yes
-10.3% to -15.9% c
See Appendix 3AD
100 ppb
Yes
-8.5% to -13.9% c
87 ppb
Yes
-12.2%
Schelegle et al., 2009
80 ppb
Yes
-7.5%
Horstman et al., 1990
-7.7%
McDonnell et al., 1991
-6.5%
Adams, 2002
-6.2% to -5.5% c
Adams, 2003
-7.0% to -6.1% c
Adams, 2006b
-7.8%
Schelegle et al., 2009
NDE
-3.5%
Kimet al., 2011F
70 ppb
Yes
-6.1%
Schelegle et al., 2009 1
60 ppb
Yes
G
-2.9%
-2.8%
Adams, 2006b; Brown et al., 2008
Yes
-1.7%
Kim et al., 2011
No
-3.5%
Schelegle et al., 2009
40 ppb
No
-1.2%
Adams, 2002
No
-0.2%
Adams, 2006b
Increased
Respiratory
Symptoms
120 ppb
Yes
Increased symptom
scores
See Appendix 3AD
100 ppb
Yes
87 ppb
Yes
80 ppb
Yes
70 ppb
Yes
60 ppb
No
40 ppb
No
Airway
Inflammation
80 ppb
Yes
Multiple indicatorsH
Devlin et al., 1991; Alexis et al., 2010
60 ppb
Yes
Increased neutrophils
Kim et al., 2011
Increased
Airway
Resistance and
Responsiveness
120 ppb
Yes
Increased
Horstman et al., 1990; Folinsbee et al.,
1994 (O3 induced sRaw not reported)
100 ppb
Yes
Horstman et al., 1990
80 ppb
Yes
Horstman et al., 1990
* This is the average concentration across the six exercise periods as targeted by authors. This differs from the time-weighted
average concentration for the full exposure periods (targeted or actual). For example, as shown in Appendix 3A, Table 3A-2, in
chamber studies implementing a varying concentration protocol with targets of 0.03, 0.07, 0.10,0.15, 0.08 and 0.05 ppm, the
exercise period average concentration is 0.08 ppm while the time weighted average for the full exposure period (based on
targets) is 0.082 ppm due to the 0.6 hour lunchtime exposure between periods 3 and 4.
3 Statistical significance based on the O3 compared to filtered air response at the study group mean (rounded here to decimal).
3 Ranges reflect the minimum to maximum FEV1 decrements across multiple exposure designs and studies. Study-specific
values and exposure details provided in Appendix 3A, Tables 3A-1 and 3A-2, respectively.

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3 Citations for FEVi and respiratory symptoms findings for exposures above 80 ppb are in Appendix 3A and not repeated here.
E ND (not determined) indicates these data have not been subjected to statistical testing.
F The data for 30 subjects exposed to 80 ppb by Kim et al. (2011) are presented in Figure 5 of McDonnell et al. (2012).
3 Adams (2006b) reported FEVi data for 60 ppb exposure by both constant and varying concentration designs. Subsequent
analysis of the FEVi data from the former found the group mean O3 response to be statistically significant (p < 0.002) (Brown et
al., 2008; 2013 ISA, section 6.2.1.1). The varying-concentration design data were not analyzed by Brown et al., 2008.
H Increased numbers of bronchoalveolar neutrophils, permeability of respiratory tract epithelial lining, cell damage, production of
jroinflammatory cytokines and prostaglandins (ISA, Appendix 3, section 3.1.4.4.1; 2013 ISA, section 6.2.3.1).	
7.	p. 4A-27, "Attachment 1 to Appendix A" should say "Attachment 1 to Appendix 4A"
8.	Appendix 4A, Tables 4A-7 and 4A-8 - Some entries in these tables are incorrect due to a
minor typographical error in a cell of Table 4A-8 (the first column, "y2" entry, 476.6
should have been 471.6) that affected downstream calculations. Corrected tables are
provided on the following pages.

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Table 4A-7. Comparison of total aspen above ground biomass estimated for different patterns of varying annual exposures
and constant exposure equal to 3-year average (17 ppm-hrs).

"ambient"
(control
in King)
biomass
Growth -
%
increase
W126=17,
biomass
(g/m2)
W126=10,
24,17,
etc -
biomass
(g/m2)
W126=
24,17,
10, etc -
biomass
(g/m2)
W126=
24,10,
17, etc -
biomass
(g/m2)
W126=
10,17,
24 etc -
biomass
(g/m2)
%
difference
in total
tree
biomass
of
W126=10,
24,17, vs
17
%
difference
in total
tree
biomass
of W126=
24,17,10
vs 17
%
difference
in total
tree
biomass
of W126=
24,10,17
vs 17
%
difference
in total
tree
biomass
of W126=
10,17, 24
vs 17
yO-
1997
9.1

9.1
9.1
9.1
9.1
9.1




yi
280.2
2979.1%
253.6
266.1
240.9
240.9
266.1
4.9%
-5.0%
-5.0%
4.9%
y2
844.5
201.4%
762.6
748.6
749.9
775.8
775.1
-1.8%
-1.7%
1.7%
1.6%
y3
1330.5
57.5%
1201.0
1187.0
1210.6
1214.2
1190.6
-1.2%
0.8%
1.1%
-0.9%
y4
1576.1
18.5%
1422.5
1419.8
1420.6
1424.2
1423.5
-0.2%
-0.1%
0.1%
0.1%
y5
2094.4
32.9%
1890.0
1862.9
1888.1
1915.6
1891.0
-1.4%
-0.1%
1.3%
0.0%
y6-
2003
2690.2
28.4%
2427.5
2400.3
2452.9
2453.0
2400.4
-1.1%
1.0%
1.1%
-1.1%

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Table 4A-8. Aboveground growth calculations for subset of scenarios.

"ambient"
(control
in King)
annual
WOOD
growth
that year
"ambient"
(control
in King)
annual
FOLIAGE
growth
that year
"ambient"
(control
in King)
annual
growth
that year
(uses yr-
yr delta
for
foliage)
"ambient"
(control in
King)
aboveground
biomass
Growth -
%
increase
03
W126
(ppm-
hrs)
Os-
impact
(RBL)
W126=17
biomass
(fl/m*)
03W126
(ppm-hrs)
- low->hi-
>ave
03-
impact
(RBL)
W126=10,
24,17, etc
- biomass
(fl/m*)
% diff
from
constant
3-yr ave
yO
(1997)
7.6
1.5

9.1



9.1


9.1

yi
226.1
46.5
271.1
280.2
2979.1%
17.0
0.098
253.6
10.0
0.052
266.1

y2
471.6
139.2
564.3
844.5
201.4%
17.0
0.098
762.6
24.0
0.145
748.6

y3
390.5
234.7
486
1330.5
57.5%
17.0
0.098
1201.0
17.0
0.098
1187.0
-1.2%
y4
209
271.3
245.6
1576.1
18.5%
17.0
0.098
1422.5
10.0
0.052
1419.8
-0.2%
y5
434.5
355.1
518.3
2094.4
32.9%
17.0
0.098
1890.0
24.0
0.145
1862.9
-1.4%
ye
(2003)
500.1
450.8
595.8
2690.2
28.4%
17.0
0.098
2427.5
17.0
0.098
2400.3
-1.1%

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