United States
Environmental Protection
1=1 m m Agency
EPA/690/R-11 /021F
Final
8-17-2011
Provisional Peer-Reviewed Toxicity Values for
Dicyclohexylamine
(CASRN 101-83-7)
Superfund Health Risk Technical Support Center
National Center for Environmental Assessment
Office of Research and Development
U.S. Environmental Protection Agency
Cincinnati, OH 45268

-------
AUTHORS, CONTRIBUTORS, AND REVIEWERS
CHEMICAL MANAGER:
Harlal Choudhury, National Center for Environmental Assessment, Cincinnati, OH
DRAFT DOCUMENT PREPARED BY:
National Center for Environmental Assessment, Cincinnati, OH
This document was externally peer-reviewed under contract to:
Eastern Research Group, Inc.
110 Hartwell Avenue
Lexington, MA 02421-3136
Questions regarding the contents of this document may be directed to the U.S. EPA Office of
Research and Development's National Center for Environmental Assessment, Superfund Health
Risk Technical Support Center (513-569-7300).
l

-------
TABLE OF CONTENTS
COMMONLY USED ABBREVIATIONS	iii
BACKGROUND	1
DISCLAIMERS	1
QUESTIONS REGARDING PPRTVS	 1
INTRODUCTION	2
REVIEW OF POTENTIALLY RELEVANT DATA (CANCER AND NONCANCER)	3
DERIVATION 01 PROVISIONAL VALUES	3
CANCER WEIGHT OF EVIDENCE (WOE) DESCRIPTOR	4
MODE-OF-ACTION (MOA) DISCUSSION	4
REFERENCES	4
li

-------
COMMONLY USED ABBREVIATIONS
BMC
benchmark concentration
BMD
benchmark dose
BMCL
benchmark concentration lower bound 95% confidence interval
BMDL
benchmark dose lower bound 95% confidence interval
HEC
human equivalent concentration
HED
human equivalent dose
IUR
inhalation unit risk
LOAEL
lowest-observed-adverse-effect level
LOAELadj
LOAEL adjusted to continuous exposure duration
LOAELhec
LOAEL adjusted for dosimetric differences across species to a human
NOAEL
no-ob served-adverse-effect level
NOAELadj
NOAEL adjusted to continuous exposure duration
NOAELhec
NOAEL adjusted for dosimetric differences across species to a human
NOEL
no-ob served-effect level
OSF
oral slope factor
p-IUR
provisional inhalation unit risk
p-OSF
provisional oral slope factor
p-RfC
provisional reference concentration (inhalation)
p-RfD
provisional reference dose (oral)
POD
point of departure
RfC
reference concentration (inhalation)
RfD
reference dose (oral)
UF
uncertainty factor
UFa
animal-to-human uncertainty factor
UFC
composite uncertainty factor
UFd
incomplete-to-complete database uncertainty factor
UFh
interhuman uncertainty factor
UFl
LOAEL-to-NOAEL uncertainty factor
UFS
subchronic-to-chronic uncertainty factor
WOE
weight of evidence
11

-------
FINAL
8-17-2011
PROVISIONAL PEER-REVIEWED TOXICITY VALUES FOR
DICYCLOHEXYLAMINE (CASRN 101-83-7)
BACKGROUND
A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value
derived for use in the Superfund Program. PPRTVs are derived after a review of the relevant
scientific literature using established Agency guidance on human health toxicity value
derivations. All PPRTV assessments receive internal review by a standing panel of National
Center for Environment Assessment (NCEA) scientists and an independent external peer review
by three scientific experts.
The purpose of this document is to provide support for the hazard and dose-response
assessment pertaining to chronic and subchronic exposures to substances of concern, to present
the major conclusions reached in the hazard identification and derivation of the PPRTVs, and to
characterize the overall confidence in these conclusions and toxicity values. It is not intended to
be a comprehensive treatise on the chemical or toxicological nature of this substance.
The PPRTV review process provides needed toxicity values in a quick turnaround
timeframe while maintaining scientific quality. PPRTV assessments are updated approximately
on a 5-year cycle for new data or methodologies that might impact the toxicity values or
characterization of potential for adverse human health effects and are revised as appropriate. It is
important to utilize the PPRTV database (http://hhpprtv.ornl.gov) to obtain the current
information available. When a final Integrated Risk Information System (IRIS) assessment is
made publicly available on the Internet (www.epa.gov/iris), the respective PPRTVs are removed
from the database.
DISCLAIMERS
The PPRTV document provides toxicity values and information about the adverse effects
of the chemical and the evidence on which the value is based, including the strengths and
limitations of the data. All users are advised to review the information provided in this
document to ensure that the PPRTV used is appropriate for the types of exposures and
circumstances at the site in question and the risk management decision that would be supported
by the risk assessment.
Other U.S. Environmental Protection Agency (EPA) programs or external parties who
may choose to use PPRTVs are advised that Superfund resources will not generally be used to
respond to challenges, if any, of PPRTVs used in a context outside of the Superfund program.
QUESTIONS REGARDING PPRTVS
Questions regarding the contents and appropriate use of this PPRTV assessment should
be directed to the EPA Office of Research and Development's National Center for
Environmental Assessment, Superfund Health Risk Technical Support Center (513-569-7300).
1
Di cy cl ohexyl amine

-------
FINAL
8-17-2011
INTRODUCTION
Dicyclohexylamine, CAS No. 101-83-7, is a secondary aliphatic amine used as a
chemical intermediate in the production of corrosion inhibitors, insecticides, paper and textile
auxiliaries, emulsifiers, oil additives, vulcanization accelerators, plasticizers, and dyestuff
precursors (Berufsgenossenschaft, 2000). The molecular formula for dicyclohexylamine is
C12-H23-N (see Figure 1). A table of physicochemical properties is provided below (see
Table 1).
H
Figure 1. Dicyclohexylamine Structure
Table 1. Physicochemical Properties Table
(Dicyclohexylamine CASRN 101-83-7)3
Property (unit)
Value
Boiling point (C)
255.8
Melting point (C)
-0.1
Density (g/cm3)
0.9104
Vapor pressure (Pa at 25C)
0.0338
pH (unitless)
No data
Solubility in water (g/100 inL at 25C)
0.08
Relative vapor density (air = 1)
6.25
Molecular weight (g/mol)
181.31
aSource: ACGIH(2010)
No reference dose (RfD), reference concentration (RfC), or cancer assessment for
dicyclohexylamine is included in the IRIS database (U.S. EPA, 2010) or on the Drinking Water
Standards and Health Advisories List (U.S. EPA, 2009). No RfD or RfC values are reported in
the Health Effects Assessment Summary Tables (HEAST) (U.S. EPA, 2003). The Chemical
Assessments and Related Activities (CARA) list does not include a Health and Environmental
Effects Profile (HEEP) for dicyclohexylamine (U.S. EPA, 1994). The toxicity of
dicyclohexylamine has not been reviewed by the Agency for Toxic Substances and Disease
Registry (ATSDR, 2010) or the World Health Organization (WHO, 2010). The California
Environmental Protection Agency (CalEPA, 2008, 2009) has not derived toxicity values for
exposure to dicyclohexylamine. No occupational exposure limits for dicyclohexylamine have
been derived by the American Conference of Governmental Industrial Hygienists
(ACGIH, 2010), listed by the National Institute of Occupational Safety and Health (NIOSH,
2005), or adopted by the Occupational Safety and Health Administration (OSHA, 2010).
2
Di cy cl ohexyl amine

-------
FINAL
8-17-2011
The HEAST (U.S. EPA, 2003) does not report any cancer values for dicyclohexylamine.
The International Agency for Research on Cancer (IARC, 2010) has reviewed the carcinogenic
potential of dicyclohexylamine. Dicyclohexylamine is not included in the 11th Report on
Carcinogens (NTP, 2005). CalEPA (2008) has not prepared a quantitative estimate of
carcinogenic potential for dicyclohexylamine.
Literature searches were conducted on sources published from 1900 through
February 4, 2011 for studies relevant to the derivation of provisional toxicity values for
dicyclohexylamine, CAS No. 101-83-7. Searches were conducted using EPA's Health and
Environmental Research Online (HERO) database of scientific literature. HERO searches the
following databases: AGRICOLA; American Chemical Society; BioOne; Cochrane Library;
DOE: Energy Information Administration, Information Bridge, and Energy Citations Database;
EBSCO: Academic Search Complete; GeoRef Preview; GPO: Government Printing Office;
Informaworld; IngentaConnect; J-STAGE: Japan Science & Technology; JSTOR: Mathematics
& Statistics and Life Sciences; NSCEP/NEPIS (EPA publications available through the National
Service Center for Environmental Publications [NSCEP] and National Environmental
Publications Internet Site [NEPIS] database); PubMed: MEDLINE and CANCERLIT databases;
SAGE; Science Direct; Scirus; Scitopia; SpringerLink; TOXNET (Toxicology Data Network):
ANEUPL, CCRIS, ChemlDplus, CIS, CRISP, DART, EMIC, EPIDEM, ETICBACK, FEDRIP,
GENE-TOX, HAPAB, HEEP, HMTC, HSDB, IRIS, ITER, LactMed, Multi-Database Search,
NIOSH, NTIS, PESTAB, PPBIB, RISKLINE, TRI; and TSCATS; Virtual Health Library; Web
of Science (searches Current Content database among others); World Health Organization; and
Worldwide Science. The following databases outside of HERO were searched for risk
assessment values: ACGM, AT SDR, CalEPA, EPA IRIS, EPA HEAST, EPA HEEP, EPA OW,
EPA TSCATS/TSCATS2, NIOSH, NTP, OSHA, and RTECS.
REVIEW OF POTENTIALLY RELEVANT DATA
(CANCER AND NONCANCER)
The literature search revealed no human or animal studies (i.e., acute-, short-term-, or
chronic-duration) for development of toxicity values for dicyclohexylamine.
DERIVATION OF PROVISIONAL VALUES
Limitations in the available data preclude development either cancer and noncancer
toxicity values for dicyclohexylamine.
3
Di cy cl ohexyl amine

-------
FINAL
8-17-2011
CANCER WEIGHT OF EVIDENCE (WOE) DESCRIPTOR
Limitations in the available data preclude development of a WOE descriptor.
MODE-OF-ACTION (MOA) DISCUSSION
Limitations in the available data preclude determination of a MOA discussion.
REFERENCES
ACGIH (American Conference of Governmental Industrial Hygienists). (2010) Threshold limit
values for chemical substances and physical agents and biological exposure indices. ACGIH,
Cincinnati, OH. As cited in HSDB (Hazardous Substances Data Bank). Available online at
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen7HSDB. Accessed on 11/9/10. 625688.
ATSDR (Agency for Toxic Substances and Disease Registry). (2010) Toxicological profile
information sheet. U.S. Department of Health and Human Services, Public Health Service.
Available online at http://www.atsdr.cdc.gov/toxprofiles/index.asp. Accessed on 11/9/10.
595415.
Berufsgenossenschaft der chemischen Industrie. (2000). Toxicological evaluations. Heidelberg,
Germany: Berufsgenossenschaft der chemischen Industrie. 666799
CalEPA (California Environmental Protection Agency). (2008) All OEHHA acute, 8-hour and
chronic reference exposure levels (chRELs) as on December 18, 2008. Office of Environmental
Health Hazard Assessment, Sacramento, CA. Available online at
http://www.oehha.ca.gov/air/allrels.html. Accessed on 11/9/10. 595416.
CalEPA (California Environmental Protection Agency). (2009) OEHHA toxicity criteria
database. Office of Environmental Health Hazard Assessment, Sacramento, CA Available
online at http://www.oehha.ca.gov/riskAChemicalDB/index.asp. Accessed on 11/9/10. 595417.
IARC (International Agency for Research on Cancer). (2010) IARC Monographs on the
evaluation of carcinogenic risks to humans. Lyon, France: IARC. Available online at
http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php. Accessed on 11/9/10. 597416.
NIOSH (National Institute for Occupational Safety and Health). (2005) NIOSH pocket guide to
chemical hazards. Index of chemical abstracts service registry numbers (CAS No.). Center for
Disease Control and Prevention, U.S. Department of Health, Education and Welfare, Atlanta,
GA. Available online at http://www.cdc.gov/niosh/npg/npgdcas.html. Accessed on 11/9/10.
625692.
4
Di cy cl ohexyl amine

-------
FINAL
8-17-2011
NTP (National Toxicology Program). (2005) 11th Report on Carcinogens. U.S. Department of
Health and Human Services, Public Health Service, National Institutes of Health, Research
Triangle Park, NC. Available online at http://ntp.niehs.nih.gov/ntp/roc/tocl 1.html. Accessed on
11/9/10. 093207.
OSHA (Occupational Safety and Health Administration). (2010) Air contaminants:
occupational safety and health standards for shipyard employment, subpart Z, toxic and
hazardous substances. U.S. Department of Labor, Washington, DC. OSHA Standard
1915.1000. Available online at
http://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=102
86. Accessed on 11/9/10. 625691.
Torbin, VF. (1976) Comparative characteristics of the embryonic action of some polymethylene
(alicyclic) series amines. Gig Sanit 7: 100-102. 666387
U.S. EPA (Environmental Protection Agency). (1994) Chemical assessments and related
activities (CARA). Office of Health and Environmental Assessment, Washington, DC;
EPA/600/R-94/904. Available online at
nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=6000lG8L.txt. Accessed on 11/9/10. 596444.
U.S. EPA (Environmental Protection Agency). (2003) Health effects assessment summary
tables (HEAST). Prepared by the Office of Research and Development, National Center for
Environmental Assessment, Cincinnati OH for the Office of Emergency and Remedial Response,
Washington, DC; EPA 540-R-97-036. Available online at http://epa-heast.ornl.gov/. Accessed
11/9/10. 595422.
U.S. EPA (Environmental Protection Agency). (2009) 2009 Edition of the drinking water
standards and health advisories. Office of Water, Washington, DC; EPA/822/R-09/011.
Available online at
http://deq.state.wy.us/wqd/groundwater/downloads/dwstandards2009%5Bl%5D.pdf. Accessed
11/9/10. 644141.
U.S. EPA (Environmental Protection Agency). (2010) Integrated risk information system
(IRIS). Office of Research and Development, National Center for Environmental Assessment,
Washington, DC. Available online at http://www.epa.gov/iris/. Accessed 11/9/10. 003752.
WHO (World Health Organization). (2010) Online catalogs for the Environmental Health
Criteria Series. Available online at http://www.who.int/ipcs/publications/ehc/en/.
Accessedl 1/9/10. 595424.
5
Di cy cl ohexyl amine

-------