EPA/600/B-18/328 The Human Exposure Model (HEM) HEM User Guide August 2018 Prepared by: Kathie Dionisio1and ICF Staff 1US Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory ------- Table of Contents Acknowledgments and Disclaimer ii 1. Overview 3 2. Installation and Running HEM 4 3. RPGen Module 5 3.1 Overview 5 3.2 Organization of RPGen code and files 6 3.3 RunningRPGen 6 3.4 Input options for control file 7 3.5 Output 8 4. Product Use Scheduler Module 8 4.1 Overview 8 4.2 Organization of Product Use Scheduler code and files 9 4.3 Runningthe Product Use Scheduler 10 4.4 Output 11 5. Source-to-dose Module 11 5.1 Overview 11 5.2 Organization of Source-to-dose code and files 11 5.3 Running Source-to-dose 13 5.4 Input options for control file 13 5.5 Output 15 Appendices 16 Appendix A: FIPS and Region Codes for RPGen control file 16 Appendix B: Data dictionary for RPGen output variables 18 Appendix C: Data dictionary for Product Use Scheduler output variables 23 Appendix D: Product use category ID codes, along with description, for use in the Source-to-dose control file 24 Appendix E: Data dictionary for daily dose output variables from Source-to-dose module 37 l ------- Acknowledgments and Disclaimer The United States Environmental Protection Agency through its Office of Research and Development funded and collaborated in the research and development of this software. This model and its default data are currently under development; this material has been distributed for evaluation purposes only, The model has not been cleared by the United States Environmental Protection Agency for general distribution. While example input data have been provided as an example, it is up to the user to verify appropriate input data are being used for a given application. This manual is draft documentation and has not been cleared for publication. 11 ------- 1. Overview The Human Exposure Model (HEM) was developed to assess product-specific near-field exposures to chemicals that occur in consumer products. The model is implemented as a modular system that will produce estimates of population distributions of chemical exposure (dose) by route, and releases to the environment. The model determines longitudinal (daily doses over a period of one year) aggregate doses for more than 1,000 chemicals from the use of over 300 categories of consumer products. At this time, the model is limited to consumer product formulations, e.g. shampoo, surface cleaner spray, etc., and excludes articles such as couches or mattresses. To develop a model to assess exposure to chemicals in consumer products, five key components are required: 1. A simulated population (together with demographic information, and characteristics of their family members and home) 2. Behavior diaries, indicating how individuals in the simulated population spend their time, including which consumer products they use 3. Data on the chemical composition (including quantitative weight fraction) of the consumer products used by the population 4. 'Habits and Practices' parameters defining how the simulated population uses the consumer products (e.g. frequency of use, duration of use, mass used, etc.) 5. Algorithms to calculate exposure (or dose, in mg chemical/kg body weight/day) based on the above. The above components have been developed as semi-independent modules, which, when run together, complete the HEM model as a whole. The model is coded in R, and currently consists of three main modules (a residence and population generator, a product scheduler, and a source-to-dose calculator). The three main modules take in a number of input data sets described herein. It is important to note that random number control across modules is impractical, however random number control has been implemented within each module. Each time a user runs an HEM module, the control file which includes information on the input files used, the run parameters, and the random number seed should be saved. A new run of any given module using the same control file should product identical results. All model code, along with default input files when available, are posted on GitHub (see specific URLs within each section below). Materials posted on GitHub can be viewed directly at the URLs provided, and each repository can be downloaded as a .zip file. However, we recommend cloning each GitHub repository locally, after which input files can be edited in local directories and modules run seamlessly using RStudio. Many helpful tutorials can be found online describing how to use GitHub with RStudio. 3 ------- 2. installation and Running HEM This section is a brief guide to installing and running HEM, a model to estimate longitudinal population distributions of near-field exposure to chemicals found in consumer product formulations. To run HEM, the user must have R installed on their computer. R is freely available. Optionally, the user may use R Studio as an interface; this may also be obtained for free. The HEM model currently consists of three semi-independent modules, as shown in Figure 1. To run the complete HEM model, users first run the RPGen residence and person generator (Module 1), to generate a simulated population of interest. This internal data file is used as input to the Product Use Scheduler (Module 2). Output from both the RPGen and Product Use Scheduler modules are used as input to Module 3, the Source-to-dose module. In the following sections, specific instructions for running each of the modules, along with required input files for each, are discussed. National surveys of population and housing char. ) Input data ( ) Internal data file 17*1 Module (code) ^ Model output 1. r Residence and Person Char. Generator (RPGen) . Pop. 1 Res. characteristics Source-to-dose (S2D; dose calculation) Aggregate, cumulative, longitudinal exposure (dose) by route and PUC Releases to envt. via waste streams (solid waste, air, wastewater) Figure 1: Overview of HEM model HEM is programmed in the open source R language. Each module of the code is dependent on various standard R packages, available on CRAN. Users should install the packages prior to running model code. Dependent packages for each module are listed below. RPGen module • data.table • stringr • ply 4 ------- • dplyr • dtplyr • ggplot2 • Rmpfr • httk • msm • truncnorm • survey Additionally, the EPA developed R package httkpop is provided along with model code, and must be installed and loaded in R from a local directory prior to running RPGen. This can be achieved by running the following command in an R command window: install.packages("M:/Pathtopackage/httkpop_0.0,5.9000.tar.gz", repos=NULL, type="source") Product Use Scheduler module • dplyr • foreach • doParallel Source-to-dose module • data.table • stringr • plyr • dplyr • dtplyr • ggplot2 3. lie rview The RPGen module randomly samples demographic data from the Public Use Microdata Sample (PUMS) data from the U.S. Census Bureau's American Community Survey, and housing data from the American Housing Survey (AHS) and the Residential Energy Consumption Survey (RECS). The dataset generated links demographic characteristics of each individual to characteristics of their home, including location (defined as region of the country), household income, house type, and household composition. The RPGen output is subsequently used as input for the Product Use Scheduler and Source-to-dose modules. The RPGen module code, along with default input files, are available at: https://github.com/HumanExposure/PopulationHousingGenerator. The hempums.csv input file is posted and available as a download at ftp://newftp.epa.gov/exposure/HEM due to its size. 5 ------- 3.2 Organization of RPGen cod files The following file structure is required for RPGen (where ... is the working directory): • . . ./RPGen/ • . . ,/RPGen/input/ • . . ,/RPGen/output/ Location of 4 .R source files Location of required input CSV and TXT files Location where output files are written; folder created automatically when running RPGen Additionally, runl.txt and run2.txt are provided as sample control files. In a typical model run, these files would be generated by the user, and would specify the user's desired input parameters. The TXT control file must be located within the /RPGen/input/ folder. The code subroutines are included in 4 source files: • HEMcontrol.R The R script that contains the control file for RPGen. Users will need to edit the working directory only. • HEMhousing.R An R script Housing Generator that merges the condensed versions of the RECS and AHS databases to describe the housing in which the generated population resides. • HEMpopgen.R An R script Population Generator that merges the condensed versions of the RECS, AHS, and PUMS databases to randomly generate and describe a population. • httkpop2.R An R script high throughput toxicokinetic population generator, which assigns information relevant to toxicokinetics to the population generated by the Population Generator. Required input files for the RPGen module are listed below. These are provided along with the model code. • HEMahs.csv A condensed version of the AHS database. Do not modify. • hempums.csv A condensed version of the PUMS database. Do not modify. • HEMrecs.csv A condensed version of the RECS database. Do not modify. • states.txt A list of FIPS code, region of the country, and state name, for each US state 3.3 F g RPGen User should first set up required file structure defined above, with appropriate input and source files, and install above dependent R packages. Within the HEMcontrol.R file, users should edit the working directory (Line 10, variable 'wd') to reflect the working directory specified in the file structure (i.e., . . ./RPGen/). User will then 'source' each of the R scripts in the R command line, and call the set-up function, using the following commands (again where ... is the working directory): 6 ------- > source('. . ,/RPGen/HEMcontrol.R') > source('. . ,/RPGen/HEMhousing.R') > source('. . ,/RPGen/HEMpopgen.R') > source('. . ,/RPGen/httkpop2.R') > HEM.setup(. . .) After the above set-up steps are complete, user should create a 'control' file, including the desired parameters for their model run. The 'runl.txt' and 'run2.txt' files are provided as examples; an example can also be seen in figure 2. Options for parameters are detailed below. After creating the control file and saving in the /RPGen/input/ folder, user can run the following command at the R command line: > HEM.run('runl.txt') When the run is complete, user will be able to access the saved output files in the /RPGen/output folder. it options for control file In the control file detailed in section 3.3 (and Figure 2), multiple options are available to the user, detailed below. • run.name The run.name can be specified to any unique name the user desires to use. Note that RPGen will automatically generate a folder with the name 'run.name' within the /RPGen/output/ folder, to store module output. • num.persons User may specify any number of people to simulate; must be an integer value. • min.age Minimum age of individuals in the simulated population; must be an integer > 0 • max.age Maximum age of individuals in the simulated population; must be an integer < 99 • gender M = male, F = female • ethnicity N = non-hispanic, M = Mexican-American, O = other-Hispanic Van" abl e, run.name num.persons niin. age max.age gender ethni ci ty race run.seed states value = test = 1000 = 0 = 99 = FM = NMO = WBNAPO = 876144637 Figure 2. Example control file for RPGen 7 ------- • race W = White, B = African American, N = Native American, A = Asian American, P = Pacific Islander, O = Other/mixed • run.seed Random number seed used to initiate run. Users may replicate previous runs by using the exact input parameters, including the run.seed. Value must be an integer from 1 to 2147483646. • states If this parameter is left blank, all states/regions will be included in the model run. Alternatively, the user can specify FIPS codes (for states) or Region codes to run the model for a specific geographic area. FIPS codes should be entered as two digit codes separated by a single space, Region codes should be entered as single digit codes separated by a single space. FIPS and Region codes are provided in Appendix A. The gender, ethnicity, and race parameters may take on multiple letter codes (as in Figure 2), however options should not include spaces. 3.5 Output When the run is complete, user will be able to access the saved output files in the /RPGen/output/run.name folder. The RPGen module outputs two files potentially of interest to the user, 'pop.csv' and 'pophouse.csv.' In both files, each row corresponds to a particular individual in the simulated population. The pop.csv file contains demographic and physiologic variables, while the pophouse.csv file contains the demographic, physiologic, and housing related variables. A data dictionary detailing all variables output in the pop.csv and pophouse.csv files is provided in Appendix B. 4. II ll ¦ I IK v; Iik , !iii||, I Mb ! 11 lie 4.1 Overview The Product Use Scheduler module provides schedules of consumer product use based on behavior diaries defining general behaviors (eating, sleeping, working, commuting, and 'idle' time) for different demographic groups. Product usage is defined for each member of a household, for 364 days (four seasons consisting of 13 weeks each), such that bystander exposure (exposure to a product which you are not the user of) can be taken into account. The Product Use Scheduler takes as input the pophouse.csv file output from the RPGen module, in addition to other required input files. Diaries of product usage output from the Product Use Scheduler are provided as input to the Source-to-dose module. The Product Use Scheduler module code, along with default input files, are available at: https://github.com/HumanExposure/ProductUseScheduler. Notes: Throughout this manual, 'product' and 'product category' may be used interchangeably. Note that any use of the term 'product' does not refer to the specific formulation of a product, rather 'product' and 'product category' are used interchangeably to refer to the use of a generic product type (e.g. toothpaste, surface cleaner) by an individual. 8 ------- 4.2 Organization of Product Use Scheduler code files The following file structure (case-sensitive) is required for the Product Use Scheduler module (where . . . is the working directory): • . . ./ProdSched/CODE/ Location of .R source files detailed below • . . ./ProdSched/INPUTS/ Location of required input files detailed below • . . ./ProdSched/OUTPUTS/ Location where output files are written The code subroutines are included in the following source files: • AAD.R Disaggregates activities that occur multiple times in succession within an idle time block. • ABM_Main.R The main product use schedule control file, which calls and logically integrates the various subroutines, and generates and directs program output within the module. Users will typically interact with this script only. • ABS.R Loads input files, and necessary R libraries. • CAA.R Aggregates activities that occur in a cluster and computes cluster frequencies and durations. • CAD.R Disaggregates activities that occur in a cluster. • CPS.R Samples and assigns communal product use according to family labor division rules for products which satisfy communal needs. • CSF.R A utility function called by one or more of the subroutines that ensures cluster composition is determined dynamically for consistency with the individual use frequencies of the cluster components. • HCP.R Expands the pophouse.csv input file to create one input row containing characteristics of each household member. • HUP.R Uses household-level information to filter product-categories to determine each household's universe of possible product usage (based on 'Full_ENT.csv/ defining 'ever/never' rules for use). • IIT.R For a specific product category/cluster activity, identifies idle time slots in the individual's behavior diary to accommodate the activity over the full year, considering seasonality as appropriate. • INACT.R Expands individual behavior diaries by inserting activities into idle time slots. • ISP.R Uses probabilistic sampling to determine the list of product categories each individual interacts with, as well as each product categories associated frequency, duration, and mass parameters. • IUP.R Uses individual-level information to filter product categories to determine each individual's universe of product category use. 9 ------- • RID.R Randomly selects and pulls an appropriate behavior diary for each individual. • UPG.R A utility function called by one or more of the subroutines which creates a user profile of product categories the user interacts with based on probabilistic sampling of mass, duration, frequency, and prevalence for each product category. Required input files for the Product Use Scheduler module are listed below. With the exception of pophouse.csv, default versions of each of these files are provided along with the model code. • activity_diary_pool.rds This file contains sample behavior diaries for different demographic groups (working adults, non- working adults, school-aged children, and pre-school aged children). Files were generated from a related research effort [Brandon et al. 2017, Submitted, 'Simulating Exposure-Related Behaviors Using Agent-Based Models Embedded with Needs-Based Artificial Intelligence', JESEE], • FullENT.csv This file contains binary data defining if a product category will potentially 'ever' or 'never' be used by an individual or household, based on specific characteristics related to product usage, season, and characteristics of the individual/household (e.g. homes that do not have a pool will 'never' use pool chemicals; pool chemicals are 'never' used in the winter). The file also includes an indicator of product categories which are not currently considered in HEM model outputs. • pophouse.csv Demographic and household characteristics for each individual in the simulated population. This file is output from the RPGen module. • PUC_use_data.csv This file contains detailed descriptions of each product category covered in the current scope of the HEM model. Information included are: the unique product use category (PUC) ID (used when identifying the PUC(s) of interest in the control file when running the full HEM model), a description of the PUC, and variables identifying if the PUC satisfies personal or communal needs ("personal_communal"), PUC involves activities performed indoors or outdoors ("indoor_outdoor;" indicating the environment in which the associated consumer products will be used), and the cluster the PUC belongs to ("cluster;" if the PUC is a member of a cluster). The file also contains habits and practices parameters (i.e., consumer use patterns) for each PUC, including data on prevalence of use by product category (columns "Prev_M", "Prev_F", and "Prev_child" for males, females, and children respectively), frequency of use ("Freq" and "Freq_CV"), mass of product used ("Mass" and "Mass_CV"), duration of handling time ("HT" and "HT_CV"), and duration of activity time ("AT"). Values are defined by a point value, or a lognormal distribution, which is specified in the file. 4.3 F g the Product Use Scheduler User should first set up required file structure defined in section 4.2, with appropriate input and source files, and install above dependent R packages. Within the ABM_Main.R file, users should run lines corresponding to the 'ABM_Runner() function (i.e., from line 1 through where the ABM_Main.R file indicates 'End of ABM_Runner.' This will initialize the core function in the script. User should then run the Product Use Scheduler for the population generated in the RPGen Module (i.e., using the pophouse.csv file output from the RPGen Module as the input for the Product Use Scheduler module). 10 ------- Due to length of time required for running the Product Use Scheduler, the module is set up to take advantage of parallel processing. User must first edit the 'pth_str' variable in ABM_Main.R to set the working directory variable to the home folder identified above (i.e., . . ./ProdSched/). Further, edit 'housejist' variable in ABM_Main.R to specify the number of households in the pophouse.csv file (e.g., housejist <-1:1000) - the last number in the housejist should match the num.persons variable on the control file used for the RPGen run. Then, run all lines of code in the 'parallel version' section at the bottom of ABM_Main.R. 4.4 Output When the run is complete, user will be able to access the saved output files in the /ProdSched/OUTPUTS/ folder. A daily diary over one year of behavior and product use will be saved for each individual generated in RPGen. Note that each 'individual' represents the primary individual whose usage is being modeled in the household. Together with each primary individual's behavior and product use diaries, diaries of the product usage of household members living with the primary individual will also be noted within the same file. Product Use Scheduler output files are saved as 'Household_n.csv' where 'n' refers to the 'household index' in the pophouse.csv input file. A data dictionary detailing all variables output in the Household_n.csv files is provided in Appendix C. 1 v,M|, v , | \ 'i...! ii 11. rview The Source-to-dose module takes as input the population generated by the RPGen module, product use diaries generated by the Product Use Scheduler, along with other inputs detailed below. Using this data and predefined exposure scenarios, the module estimates population distributions of exposure to chemicals in consumer products. The module outputs longitudinal exposures accounting for different exposure pathways and routes. It operates on an hourly event time step, retaining daily results over one year. The Source-to-dose module code, along with default input files, are available at: https://github.com/HumanExposure/source2dose. The composition input file, NEW_composition_for_S2D.csv, is available for download at ftp://newftp.epa.gov/exposure/HEM due to it's size. 5.2 Organization of Source-to-dose code and files The following file structure is required for Source-to-dose (where ... is the working directory): . . ./Dose/ . . ./Dose/input/ . . ./Dose/output/ABM/ . . ./Dose/output/RPGen/ . . ./Dose/output/S2D/ Location of main .R source file Location of required input files (with the exception of pophouse.csv and Household_n.csv), and control file Location of Household_n.csv files output from Product Use Scheduler Location of pophouse.csv file output from RPGen Location where output files are written 11 ------- Additionally, testS2Dcontrol.txt is provided as a sample control file. In a typical model run, the control file would be generated by the user, and would specify the user's desired input parameters. The TXT control file must be located within the /Dose/input/ folder. The main code for running Source-to-dose is included in one R script, S2D.R. Required input files for the Source-to-dose module are listed below. These are provided along with the model code. • basal_vent.csv Parameters for estimating basal ventilation rate for individuals based on age and sex (identified in control file as 'vent.file' variable). • chemical_properties_new.csv Chemical properties relevant to calculating fugacity and human exposure (identified in the control file as 'chem.file' variable). • Compartment_fractions.csv Identifies, for each different partitioning group, the parameters which define how the product will partition after use (identified in the control file as 'compart.file' variable) • NEW_composition_for_S2D.csv Formulations for products in each product category, includes weight fractions for each chemical present in the formulation. This is a summary of formulations present in the CPDat database (identified in the control file as 'chem.frac.file' variable). • fugacity.csv Chemical-independent variables needed for evaluating fugacity equations (identified in the control file as 'fug.file' variable). • Household_n.csv Behavior and product-use diaries for each household, output from the Product Use Scheduler module, where 'n' identifies the household number. • pophouse.csv Demographic and household characteristics for each individual in the simulated population. This file is output from the RPGen module. • NEW_PUC_MET.CSV Associated CHAD activity code and mean value of METS associated with product use, as calculated by APEX (identified in the control file as 'puc.met.file' variable). • NEW_PUC_product_codes.csv Identification of product category unique IDs (needed for control file), description of product category, and unique codes for the groups to identify how the product will partition after use (identified in the control file as 'puc.type.file' variable). • NEW_skinsurfaceareas.csv Identification of body areas exposed to a product category during use. Fraction of the product associated with dermal contact on the body area is defined for adults and children. Variability expected in the amount of dermal exposure the body area will experience is also defined (identified in control file as 'skin.area.file' variable). • NEW_PUC_skin_wipe_rinse.csv Defines fractional partitioning of products on the hand and/or body, and how they are affected by rinsing or wiping actions (identified in control file as 'removal/file'). 12 ------- 5.3 F g Source-to-dose User should first set up required file structure defined above, with appropriate input and source files, and install above dependent R packages. Within the S2D.R file, users should edit line 5 to reflect the working directory specified in the file structure (i.e., . . ./Dose/). After the above set-up steps are complete, user should create a 'control' file, saved in . . ./Dose/input/, which includes the desired parameters for their model run. The 'testS2Dcontrol.txt' file is provided as an example; an example can also be seen in Figure 3. chera "DTX5ID3020596" puc "P.PC.020.000" fug.file "fugacity.csv" cheim. file "c hend c al_prope rt i es_H EM.c sv" chein.frac.file "c ompos it i on_for_S2D.csv" puc.type.file "PUC_product_codes. csv'" compart.file "Compartment_fractions.csv" puc.met.file "PUCJIET.csv" skin.area.file "PUC_skin_areas.csv" removal. file "PUC_skin_wipe_rinse.csv" vent.file "basal_vent.csv" diary.prefix "Househoid_" run.name "aftershave" first.house 1 last.house 1000 init.seed 23 show.progress yes parallel TO coup.method 1 Figure 3. Example control file for Source-to-dose Options for parameters are detailed below. After saving the control file, user will 'source' the main R script in the R command line, and call the main function, using the following commands (again where ... is the working directory): > source('. . ./Dose/S2D.R') > s2d('testS2Dcontrol.txt') When the run is complete, user will be able to access the saved output files in the /S2D/output folder, under the sub-folder with the same 'run.name' specified in the control file. it options for control file In the control file detailed in section 5.3 (and Figure 3), multiple options are available to the user, detailed below. When editing the control file, be sure to use spaces and not the tab key to indent the values associated with each variable. At least one space should be used between the variable name and the value, though more may be used. 13 ------- • chem List of the chemicals of interest to include in the model run. Chemicals must be identified by their DTXSID (DTXSID is a unique identifier provided by DSSTox, and available through the CompTox Chemistry Dashboard: https://comptox.epa.gov/dashboard). Chemicals listed must be present in the 'chemical_properties_HEM_withfabs.csv' and the 'composition_for_S2D.csv' input files for a dose to be calculated. Multiple chemicals may be listed in a single control file, each on their own line, and each preceded by 'chem.' If no 'chem' is listed, doses will be calculated for all chemicals present in the product category(ies) included in the control file. • puc List of product categories of interest to include in the model run. Product categories must be identified by their associated unique ID code, available in Appendix D, and in the input file "NEW_PUC_product_codes.csv". Product category must have at least one associated formulation present in the 'composition_for_S2D.csv' input file for a dose to be calculated. If product category is identified as not being included in the current HEM version in the 'FullENT.csv' input file for the Product Use Scheduler, no dose will be calculated from use of the product category. Multiple product category IDs may be listed in a single control file, each on their own line, and each preceded by 'puc.' If no 'puc' is listed, doses will be calculated across all product categories which contain the chemical(s) included in the control file. • Default input files Thefug.file, chem.file, chem.frac.file, puc.type.file, compart.file, puc.met.file, skin.area.file, removal.file, and vent.file variables all identify the required input files for running the Source-to- dose module. Users may modify the input files if files are maintained in the same format. Users should ensure that the file names listed in the control file exactly match the file names present in the . . ./Dose/input/ folder. • diary.prefix This value should match the prefix of the household behavior and product use diaries output from the Product Use Scheduler. • run.name The run.name can be specified to any unique name the user desires to use. Note that the Source to Dose module will automatically generate a folder with the name 'run.name' within the . . ./Dose/output/ folder, to store module output. If a run name is used twice under the same file path, previously saved files will be written over. • first.house The numeric identifier of the first household in the set of households you wish to run. Typically this will be 1 if user is evaluating a full set of 1 - n households. However, this parameter allows the user to start on a different household if, for example, a run is interrupted. Must be an integer value >1. • last.house The numeric identifier of the last household in the set of households you wish to run. Must be an integer value > 1. • init.seed Seed to initiate the random number generator. If a run includes the same chemical and product category list, with the same seed, results will be exactly replicated. • show.progress 14 ------- A yes/no indicator to view additional progress related messages on the R console, as the program is running. Allows the user to track progress of the run (e.g. which household the code is currently on). • parallel A yes/no indicator for the user to specify if they would like to take advantage of parallel computing power. • comp.method Variable can take on a value of 0 or 1. Value of 0 indicates the module will only assign to the users of the product category of interest formulations which contain the chemical(s) of interest. Value of 1 indicates the module will randomly draw from all formulations for a product category when assigning formulations to a particular product user; formulations assigned may or may not include the chemical(s) of interest. 5.5 Output When the run is complete, user will be able to access the saved output files in the . . ./Dose/output/S2D/run.name/ folder. The Source-to-dose module saves a daily dose file for each household in the . . ./Dose/output/S2D/run.name/Daily/ folder. Files are named in the following format: 'S2D_daily_n.csv', where 'n' is the household number. When all doses returned for a household are zero, a file is not saved for the household. A data dictionary detailing all variables output in the daily dose files is provided in Appendix E. 15 ------- Appendices Appendix A: gion Codes for RPGen control file FIPS code Region code State name 01 3 Alabama 02 4 Alaska 04 4 Arizona 05 3 Arkansas 06 4 California 08 4 Colorado 09 1 Connecticut 10 3 Delaware 11 3 District of Columbia 12 3 Florida 13 3 Georgia 15 4 Hawaii 16 4 Idaho 17 2 Illinois 18 2 Indiana 19 2 Iowa 20 2 Kansas 21 3 Kentucky 22 3 Louisiana 23 1 Maine 24 3 Maryland 25 1 Massachusetts 26 2 Michigan 27 2 Minnesota 28 3 Mississippi 29 2 Missouri 30 4 Montana 31 2 Nebraska 32 4 Nevada 33 1 New Hampshire 34 1 New Jersey 35 4 New Mexico 36 1 New York 16 ------- 37 3 North Carolina 38 2 North Dakota 39 2 Ohio 40 3 Oklahoma 41 4 Oregon 42 1 Pennsylvania 44 1 Rhode Island 45 3 South Carolina 46 2 South Dakota 47 3 Tennessee 48 3 Texas 49 4 Utah 50 1 Vermont 51 3 Virginia 53 4 Washington 54 3 West Virginia 55 2 Wisconsin 56 4 Wyoming 17 ------- Appendix B: Data dictionary for RPGen output variables Variable Name Description Population Variables from PUMS" gender gender of selected person (primary individual); Male or Female reth ethnic group (httkpop categories) compid 7-digit code; first two digits = state FIPS, last 5 digits = 2010 PUMA recno PUMS record number race W=White, B=Black, N=Native American, A=Asian, P=Pacific Islander, 0=0ther, M=Multiple ethnicity M=Mexican hispanic, 0=other hispanic, N=not hispanic age_years age in full years, rounded down (range= 0 to 96) pwgtp statistical sampling weight pool combination of database matching variables family type, house type, income, census region, and urban/rural (range 1-288) income annual household income ages 40-character string, each pair is age of one household member (range 00-96) genders 20-character string, each is M or F state 2-digit FIPS code for one of the 50 states or DC (range 01=Alabama to 56=Wyoming) Housing Variables from RECS" afuel fuel used for air conditioning; 1-electricity, 2=gas or propane, 3=other, -6=NA baths number of full bathrooms; 0-10 (capped at ten), -6=NA bedrms number of bedrooms; 0-10 (capped at ten), -6=NA built year house was built; each year for 1990+, rounded down to 5x for 1970-1989, rounded down to lOx for 1920-1969, earlier=1919 cars number of cars; 0-5 (capped at 5), -6=NA cellar type of basement; l=full basement, 2=partial basement, 3=crawl space, 4=slab, 5=other, -6=NA hequip main heating equipment; l=forced air furnace, 2=steam radiators, 3=heat pump, 4=electric baseboard, 5-14=others lot square footage of lot; range is 200 - 999,997 square feet (almost 22 acres) pwt statistical weight within AHS; used for random selection rooms number of rooms; 1-21 (capped at 21) sewdis type of sewage disposal; l=septic tank, 2=chemical toilet, 3=outhouse, 4=other, 5=none, -6=municipal system unitsf square footage of house (excl. garage, unfinished areas); 99-99998 (minimum allowed=99, capped at 99,998) 18 ------- Variable Name Description water source of water (for washing and bathing); l=water system, 2=well, 3=spring, 4=cistern, 5=stream or lake, 6=bottled, 7=other waterd source of drinking water; l=water system, 2=well, 3=spring, 4=cistern, 5=stream or lake, 6=bottled, 7=other control record number from full 2013 AHS database Housing Variables from AHS" doeid record number from 2009 RECS database nweight sampling weight hdd30yr average annual heating degree days; range 0 -13346 cdd30yr average annual cooling degree days; range 0 - 5357 kownrent own or rent house; l=owned, 2=rented, 3 = stay without rent condcoop part of condo or coop; l=condominium, 2=cooperative, -2=NA naptflrs number of floors in apartment; range 1-4, -2 = not an apartment stories number of stories in single-family home; 10=one, 20=two, 31=three, 32=4+, 40=split-level, 50=other, -2=not a single family home stoven number of oven-cooktop combinations; range 0-10 stovenfuel fuel used for stove; l=gas, 2=propane, 5=electric, 21=other stove number of cooktops (not combined with ovens); range 1-10 stovefuel fuel used for cooktop; l=gas, 2=propane, 5=electric, 21=other oven number of ovens (not combined with cooktops); range 0-10 ovenfuel fuel used for oven; l=gas, 2=propane, 5=electric, 21=other ovenuse frequency of oven use; 0=not used, 1=3+ per day, 2=twice per day, 3=once per day, 4 = few times per week, 5=l/week, 6=less outgrill outdoor grill used; 0=no, l=yes dishwash dishwasher used in home; 0=no, l=yes cwasher clothes washer used in home; 0=no, l=yes washload frequency clothes washer used; l=l/week or less, 2=2-4 per week, 3=5-9 per week, 4=10-15 per week, 5= 16+ per week dryer clothes dryer used in home; 0=no, l=yes dryruse frequency clothes dryer used; l=every time clothes washed, 2=sometimes when clothes washed, 3=rarely, -2=NA tvcolor number of televisions used in home; range 0-15 computer computer used at home; 0=no, l=yes numpc number of computers; range 0-15 pcprint number of printers used at home; range 0-9, -2=NA moisture humidifier used at home; 0=no, l=yes 19 ------- Variable Name Description prkgplcl have an attached garage; 0=no, l=yes prkgplc2 have a detached garage or carport; 0=no, l=yes cooltype type of air conditioning system; l=central, 2=window/wall, 3=both, -2=none tempniteac temperature setting at night (in warm weather); range 45-96, -2=no AC numberac number of window/wall AC units; range 1-15, -2=NA numcfan number of ceiling fans used; range 0-15 notmoist dehumidifier used at home; 0=no, l=yes highceil high ceilings in home; 0=no, l=yes windows number of windows in heated areas of home; 0=none, 10=1-2, 20=3-5, 30=6-9, 41=10-15, 42=16-19, 50=20-29, 60=30+ adqinsul level of insulation; l=well insulated, 2=adequate, 3=poor, 4=none drafty home drafty in winter; l=always, 2=mostly, 3=sometimes, 4=never swim swimming pool or hot tub; 0=none, l=hot tub only, 2=pool only, 3=both Physiological Variables from HTTKPop meanjogh mean of log(height) for this age-gender group meanjogbw mean of log(body weight) for this age-gender group weight body weight in kilograms; calculated from meanjogbw and logbw_resid height height in centimeters; calculated from meanjogh and logh_resid blood mass mass of blood (kg) brain mass mass of brain (kg) gonads_mass mass of gonads (kg) heart mass mass of heart (kg) kidneys_mass mass of kidneys (kg) large_intestine_mass mass of large intestines (kg) liver mass mass of liver (kg) lungjnass mass of lungs (kg) muscle mass mass of muscular tissue (kg) pancreas_mass mass of pancreas (kg) skeleton mass bone mass (kg) skin mass mass of skin tissue (kg) small_intestine_mass mass of small intestines (kg) 20 ------- Variable Name Description spleen_mass mass of spleen (kg) stomach mass mass of stomach (kg) adipose_flow blood flow in adipose tissue () brain flow blood flow in brain () CO Cardiac output, L/h gonads_flow blood flow in gonads () heart flow blood flow to heart muscle (not into heart) kidneys_flow blood flow to kidneys () la rgejntesti ne_flow blood flow to large intestines () liver flow blood flow in liver () lung_flow blood flow to lung tissue () muscle flow blood flow to muscles () pancreas_flow blood flow to pancreas () skeleton flow blood flow to bone tissue () skin flow blood to to skin tissue () small intestine flow blood flow to small intestines () spleen_flow blood flow to spleen () stomach flow blood flow to stomach () other mass mass of other tissues (kg) adipose_mass mass of adipose tissue (kg) org_flow_check relevant to httkpop r package weight_adj adjusted body weight (sum of organ masses) (kg) BSA_adj adjusted body surface area (cm2) million.cells.per.gliver Hepatocellularity, million cells/g liver hematocrit Percent volume of red blood cells in the blood serum creat Serum creatinine, mg/dL gfr_est Estimated glomerular filtration rate, mL/min/1.73m2 BSA bmi_adj adjusted body mass index bmi body mass index BSA body surface area (cm2) 21 ------- Variable Name Description Variables added by Module to Interface Input Datasets row row number for this record on this data set agejnonths age in full months (range 0-1163) num row number for this record on this data set logbw_resid residual in regression of log(body weight); random sample generated using HEM random seed logh_resid residual in regression of log(height); random sample generated using HEM random seed 22 ------- Appendix C: Data dictionary for Prodi leduler output variables Variable Name Units Variable Description householdjndex -- Unique household ID, equal to the index number in the RPGen output (pophouse.csv), used as a household identifier personindex -- Number assigned to each person in each household; corresponds to the order in which the person's age is listed in the RPGen output (pophouse.csv) Diary.category -- Type of diary from the activity diary pool that has been assigned to an individual person.gender -- Gender of the person specified: Male (M) or Female (F) person.age Years Age of the person specified in years Day.of.the.year -- Integer indicating day of the year, from 1 (January 1) to 364 (assuming 52 weeks of 7 days each) Start.Time.hr. using, military .time Military time Start time of an activity (military time) End.Time.hr. using, military .time Military time End time of an activity (military time) Duration.hr Hours Duration of an activity Duration.min Minutes Duration of an activity Activity.Code -- Activity performed during that time period: -2: idle time with an activity assignment -1: idle time with no activity assignment 1: morning commute 2: evening commute 3: breakfast 4: dinner 5: lunch 6: sleep 7: work Personal.or.Communal -- Specifies if a PUC satisfies personal or communal needs Clusters -- Specifies the cluster a PUC belongs to, if the PUC belongs to a cluster. Clusters are groups of PUCs that are often used in-tandem when performing a task. Indoor.outdoor -- Indicator if products are typically used indoors or outdoors Primary.person -- Binary variable to identify the primary person (1) in each household (the primary person is designated in the pophouse.csv file) PUCID.producttype -- Product type ID PUCID.PT.description -- Product type description sheds.id.refined -- Refined product type ID use.act Minutes Activity time use.ht Minutes Handling time use.mass Grams Mass of product used 23 ------- Appendix D: Product use categn |i > codes, along with descripti i> ' r us-¦ in 1 lie Source-to-dose control file PUC ID General category Product type Refined type Description AC.0500.010.050.F Arts and crafts/Office supplies arts and crafts adhesive spray spray adhesives for primarily craft purposes, including spray mounts and stencil placement sprays AC.0500.010.099.F Arts and crafts/Office supplies arts and crafts adhesive NOC glue sticks, glitter glues, fabric glues, craft glue, and other adhesives used for primarily craft purposes AC.0500.020.099.F Arts and crafts/Office supplies arts and crafts cleaner NOC solvent-based products for cleaning paint, adhesives, etc. from hands or surfaces AC.0500.030.050.F Arts and crafts/Office supplies arts and crafts finish spray spray shellacs or polyurethane coatings for primarily craft purposes AC.0500.030.099.F Arts and crafts/Office supplies arts and crafts finish NOC shellacs or polyurethane coatings for primarily craft purposes AC.0500.040.099.F Arts and crafts/Office supplies arts and crafts paint NOC paints and colorants for primarily craft purposes (including acrylic and enamel paints) AC.0100.010.050.F Arts and crafts/Office supplies body paint spray body paints, markers, glitters, play cosmetics, and Halloween cosmetics (spray or aerosol formulation specified) AC.0100.010.099.F Arts and crafts/Office supplies body paint NOC body paints, markers, glitters, play cosmetics, and Halloween cosmetics AC.0200.010.099.F Arts and crafts/Office supplies bubble solution NOC liquid bubble solutions, including solutions for bubble machines AC.0500.050.099.F Arts and crafts/Office supplies craft kit NOC multi-component crafting kits where individual products are not designated AC.0200.020.099.F Arts and crafts/Office supplies crayons NOC wax crayons for coloring or illustration AC.0300.010.099.F Arts and crafts/Office supplies fabric dye NOC products for dying fabrics AC.0300.020.050.F Arts and crafts/Office supplies fabric paints and sealers spray paints or sealers for treating fabrics (spray or aerosol formulation specified) AC.0300.020.099.F Arts and crafts/Office supplies fabric paints and sealers NOC paints or sealers for treating fabrics AC.0200.030.099.F Arts and crafts/Office supplies finger paint NOC non-edible finger paints AC.0500.060.050.F Arts and crafts/Office supplies flocking spray flocking and artificial snow (spray or aerosol formulation specified) AC.0400.010.099.F Arts and crafts/Office supplies fogger NOC liquid solutions for fogger machines AC.0800.010.099.F Arts and crafts/Office supplies glaze NOC liquid products for glazing craft pottery AC.0600.010.099.F Arts and crafts/Office supplies gun cleaner NOC liquid solutions for cleaning interior or exterior of firearms AC.0700.020.099.F Arts and crafts/Office supplies pens and markers NOC writing utensils containing liquid or gel ink AC.0200.040.099.F Arts and crafts/Office supplies play dough NOC children's play modeling clays VE.0500.010.099. F Vehicle antifreeze NOC antifreeze and/or coolant solutions for motorized vehicles VE.0300.010.050. F Vehicle auto air freshener spray air fresheners for car interiors (spray or aerosol formulation specified) VE.0300.010.099. F Vehicle auto air freshener NOC air fresheners for car interiors, including products for vents 24 ------- VE.0500.020.050. F Vehicle auto fluids and additives spray power steering fluids, transmission fluids, brake fluids, fuel injector cleaners, gas treatments, or leak stoppers (spray or aerosol formulation specified) VE.0500.020.099. F Vehicle auto fluids and additives NOC power steering fluids, transmission fluids, brake fluids, fuel injector cleaners, gas treatments, or leak stoppers VE.0500.030.050. F Vehicle auto lubricant spray engine lubricants and belt dressings, not including motor oils (spray or aerosol formulation specified) VE.0500.030.099. F Vehicle auto lubricant NOC engine lubricants and belt dressings, not including motor oils VE.0100.010.050. F Vehicle auto paint spray paints and primers for auto body or engine (spray or aerosol formulation specified) VE.0100.010.099. F Vehicle auto paint NOC paints and primers for auto body or engine VE.0500.040.099. F Vehicle auto refrigerant NOC refrigerants and Freon products for auto applications VE.0200.020.099. F Vehicle boat cleaner - general NOC cleaners, washes, and polishes for exterior marine applications VE.0200.040.099. F Vehicle boat engine fluids NOC engine fluids for marine applications VE.0400.010.099. F Vehicle body cleaner NOC cleaners, shampoos, and washes for auto body exterior (not including wax products) VE.0100.020.050. F Vehicle body repair spray products for repairing auto body exteriors, including bondo-type products and scratch fillers (spray or aerosol formulation specified) VE.0100.020.099. F Vehicle body repair NOC products for repairing auto body exteriors, including bondo-type products and scratch fillers VE.0400.020.050. F Vehicle body wax spray auto body waxes and coatings, including combo wash/wax products (spray or aerosol formulation specified) VE.0400.020.099. F Vehicle body wax NOC auto body waxes and coatings, including combo wash/wax products VE.0400.040.050. F Vehicle degreaser spray auto, engine and brake degreasers (spray or aerosol formulation specified) VE.0400.040.099. F Vehicle degreaser NOC auto, engine and brake degreasers VE.0100.030.050. F Vehicle detailing spray products for cleaning, polishing, or protecting car interior surfaces, upholstery, leather, carpeting, tires, or rims (spray or aerosol formulation specified VE.0100.030.099. F Vehicle detailing NOC products for cleaning, polishing, or protecting car interior surfaces, upholstery, leather, carpeting, tires, or rims VE.0500.050.099. F Vehicle motor oil NOC petroleum-based or synthetic engine lubricants VE.0100.040.050. F Vehicle windows/windshield spray products for washing or protecting windshields or windows (spray or aerosol formulation specified) VE.0100.040.099. F Vehicle windows/windshield NOC products for washing or protecting windshields or windows HM.0100.010.050. F Home maintenance adhesive remover spray solvent products for removing adhesives from surfaces (spray or aerosol formulation specified) HM.0100.010.099. F Home maintenance adhesive remover NOC solvent products for removing adhesives from surfaces HM.0400.010.099. F Home maintenance caulk/sealant NOC caulks and sealers for household use, including silicone products HM.0500.010.099. F Home maintenance concrete NOC products for patching or cleaning concrete surfaces 25 ------- HM.0600.010.050. F Home maintenance corrosion protection spray products for protecting metal surfaces from corrosion or removing corrosion (spray or aerosol formulation specified) HM.0600.010.099. F Home maintenance corrosion protection NOC products for protecting metal surfaces from corrosion or removing corrosion HM.0700.010.099. F Home maintenance degreaser NOC products for degreasing indoor surfaces HM.0800.010.050. F Home maintenance finish spray products for permanently coating and protecting wood surfaces, including polyurethane products (spray or aerosol formulation specified) HM.0800.010.099. F Home maintenance finish NOC products for permanently coating and protecting wood surfaces, including polyurethane products HM.2100.010.099. F Home maintenance grout sealer NOC products for coating and protecting tile or grout HM.1200.010.099. F Home maintenance lock deicer NOC products for deicing car or residential locks HM.1300.010.050. F Home maintenance lubricant spray household maintenance lubricants (spray or aerosol formulation specified) HM.1300.010.099. F Home maintenance lubricant NOC household maintenance lubricants HM.2100.020.099. F Home maintenance mortar or grout NOC products for attaching and grouting interior tiles HM.0100.020.050. F Home maintenance multipurpose adhesive spray general purpose repair adhesives including all-purpose glues, super glue, and epoxies; not including wood glues (spray or aerosol formulation specified) HM.0100.020.099. F Home maintenance multipurpose adhesive NOC general purpose repair adhesives including all-purpose glues, super glue, and epoxies; not including wood glues HM.1400.010.040. F Home maintenance paint exterior home improvement paints characterized as exterior use HM.1400.010.041.F Home maintenance paint interior home improvement paints characterized as interior use HM.1400.010.050. F Home maintenance paint spray home improvement paints not characterized as to interior or exterior use (spray or aerosol formulation specified) HM.1400.010.099. F Home maintenance paint NOC home improvement paints not characterized as to interior or exterior use HM.1400.020.050. F Home maintenance paint cleaner spray paint removing products for clean-up (spray or aerosol formulation specified) HM.1400.020.099. F Home maintenance paint cleaner NOC paint removing products for clean-up HM.1400.030.099. F Home maintenance paint texture NOC textured paints including ceiling texture HM.1400.040.099. F Home maintenance paint thinner NOC paint or lacquer thinners HM.1500.010.099. F Home maintenance patch and repair NOC drywall, ceiling, and joint compounds, spackles, or fillers HM.1600.010.099. F Home maintenance plumbing NOC miscellaneous plumbing repair products (putties, tapes, cements) HM.1400.050.040. F Home maintenance primer exterior home improvement primers characterized as exterior use HM.1400.050.041.F Home maintenance primer interior home improvement primers characterized as interior use HM.1400.050.050. F Home maintenance primer spray home improvement primers not characterized as to interior or exterior use (spray or aerosol formulation specified) HM.1400.050.099. F Home maintenance primer NOC home improvement primers not characterized as to interior or exterior use HM. 1500.020.099. F Home maintenance putty or filler NOC putty-type crack, hole, and wood fillers 26 ------- HM.1700.010.099. F Home maintenance refrigerant NOC air conditioner or other refrigerants HM.1800.010.099. F Home maintenance roof NOC products for roof maintenance or repair, including cleaners, sealers, or coatings HM.1900.010.099. F Home maintenance septic system NOC septic system treatment products HM.1000.010.099. F Home maintenance spray foam NOC spray insulation and weather stripping products HM.1400.060.040. F Home maintenance stain exterior wood stains characterized as exterior use, including deck stains HM.1400.060.099. F Home maintenance stain NOC wood stains not characterized as interior or exterior use HM.1400.070.050. F Home maintenance stripper spray paint and finish strippers (spray or aerosol formulation specified) HM.1400.070.099. F Home maintenance stripper NOC paint and finish strippers HM.2000.040.040. F Home maintenance surface sealer exterior products for coating and protecting household surfaces characterized as exterior use HM.2000.040.050. F Home maintenance surface sealer spray products for coating and protecting household surfaces not characterized as interior or exterior use (spray or aerosol formulation specified) HM.2000.040.099. F Home maintenance surface sealer NOC products for coating and protecting household surfaces not characterized as interior or exterior use HM.2400.010.099. F Home maintenance welding NOC miscellaneous welding products including gases, fluxes, and adhesives HM.0100.030.099. F Home maintenance wood adhesive NOC adhesives specifically characterized as wood glues EL.0300.050.099.F Electronics/small appliances printer ink NOC ink for inkjet printers EL.0300.060.099.F Electronics/small appliances printer toner NOC laser printer toners AC.0700.030.099.F Arts and crafts/Office supplies white out NOC correction fluids for ink or type CP.0100.010.051.F Cleaning products and household care air freshener gel home air fresheners (gel formulation specified) CP.0100.010.052. F Cleaning products and household care air freshener liquid home air fresheners (liquid formulation specified) CP.0100.010.054. F Cleaning products and household care air freshener oil or diffuse home air fresheners (oil formulations or diffusers) CP.0100.010.050. F Cleaning products and household care air freshener spray home air fresheners (spray or aerosol formulation specified) CP.0100.010.099. F Cleaning products and household care air freshener NOC home air fresheners CP.0400.020.099. F Cleaning products and household care automatic dishwashing additive NOC rinse aids, spot removers, and dishwasher cleaners CP.0400.030.051. F Cleaning products and household care automatic dishwashing detergent gel detergents for automatic dishwashers (gel formulation specified) CP.0400.030.053. F Cleaning products and household care automatic dishwashing detergent powder detergents for automatic dishwashers (powder formulation specified) CP.0400.030.099. F Cleaning products and household care automatic dishwashing detergent NOC detergents for automatic dishwashers 27 ------- CP.0200.010.050. F Cleaning products and household care bathroom cleaner spray bathtub, tile, and toilet surface cleaners (spray or aerosol formulation specified) CP.0200.010.099. F Cleaning products and household care bathroom cleaner NOC bathtub, tile, and toilet surface cleaners CP.0700.010.099. F Cleaning products and household care bleach NOC bleaches (including color-safe bleaches) CP.0300.010.050. F Cleaning products and household care carpet cleaner spray carpet cleaning products and machine solutions (spray or aerosol formulation specified) CP.0300.010.099. F Cleaning products and household care carpet cleaner NOC carpet cleaning products and machine solutions CP.0300.020.099. F Cleaning products and household care carpet deodorizer NOC carpet deodorizers CP.0400.040.099. F Cleaning products and household care dish soap NOC hand dish washing liquids and detergents CP.0700.020.050. F Cleaning products and household care disinfectant spray disinfecting liquids (spray or aerosol formulation specified) CP.0700.020.099. F Cleaning products and household care disinfectant NOC disinfecting liquids (including wipes) CP.0500.010.099. F Cleaning products and household care drain NOC drain openers or digesters CP.1200.010.099. F Cleaning products and household care dry cleaner NOC dry cleaning fluids or kits for home use CP. 1200.020.099. F Cleaning products and household care dryer sheets NOC dryer fabric softener sheets EL.0400.010.050.F Electronics/small appliances electronics cleaner spray miscellaneous products for cleaning home electronic equipment (including surface cleaners or cleaners for interior parts) (spray or aerosol formulation spec EL.0400.010.099.F Electronics/small appliances electronics cleaner NOC miscellaneous products for cleaning home electronic equipment (including surface cleaners or cleaners for interior parts) CP. 1200.030.099. F Cleaning products and household care fabric deodorizer NOC spray fabric deodorizers CP.1200.040.099. F Cleaning products and household care fabric protectant NOC fabric protectants and wrinkle releasers CP. 1200.050.099. F Cleaning products and household care fabric softener NOC fabric softeners (excluding dryer sheets) CP.0600.010.099. F Cleaning products and household care fireplace NOC miscellaneous fireplace and fire pit products CP.0300.030.099. F Cleaning products and household care floor cleaner NOC hard floor cleaners (including pre-moistened wipes and pads) CP.0300.040.099. F Cleaning products and household care floor polish NOC hard floor shining and waxing products 28 ------- CP.0700.030.050. F Cleaning products and household care glass cleaner spray glass and window cleaners (spray or aerosol formulation specified) CP.0700.030.099. F Cleaning products and household care glass cleaner NOC glass and window cleaners CP.0800.010.099. F Cleaning products and household care hand cleaner NOC products marketed as hand cleaners (solvent-based) CP.0900.010.050. F Cleaning products and household care heavy duty cleaner spray heavy duty or concentrated multipurpose cleaners (spray or aerosol formulation specified) CP.0900.010.099. F Cleaning products and household care heavy duty cleaner NOC heavy duty or concentrated multipurpose cleaners CP.1000.010.050. F Cleaning products and household care houseplant care spray houseplant and cut flower foods, fertilizers, or pesticides (spray or aerosol formulation specified) CP.1000.010.099. F Cleaning products and household care houseplant care NOC houseplant and cut flower foods, fertilizers, or pesticides CP.1100.010.099.F Cleaning products and household care lamp oil/lighter fluid NOC lighters, lighter fluids, and other indoor fuels CP.1200.060.052.F Cleaning products and household care laundry detergent liquid laundry detergents and soaps (liquid formulation specified) CP.1200.060.053.F Cleaning products and household care laundry detergent powder laundry detergents and soaps (powder formulation specified) CP. 1200.060.099. F Cleaning products and household care laundry detergent NOC laundry detergents and soaps CP. 1200.070.099. F Cleaning products and household care laundry fragrance NOC scent products to be added to wash CP. 1200.080.050. F Cleaning products and household care laundry stain remover spray stain removers or laundry pre-treatment products (spray or aerosol formulation specified) CP. 1200.080.099. F Cleaning products and household care laundry stain remover NOC stain removers or laundry pre-treatment products CP. 1200.090.050. F Cleaning products and household care laundry starch spray fabric starches (spray or aerosol formulation specified) CP. 1200.090.099. F Cleaning products and household care laundry starch NOC fabric starches CP.1300.010.099. F Cleaning products and household care lime remover NOC products for removing lime or scale from surfaces CP.1400.010.099. F Cleaning products and household care metal polish NOC cleaning products for metal surfaces CP.1500.010.050. F Cleaning products and household care oven cleaner spray oven and grill cleaners (spray or aerosol formulation specified) CP.1500.010.099. F Cleaning products and household care oven cleaner NOC oven and grill cleaners 29 ------- CP.1600.010.099. F Cleaning products and household care shoe polish or protectant NOC shoe polishes, cleaners, and protectants CP.0700.040.050. F Cleaning products and household care surface cleaner spray hard surface and kitchen surface cleaners (spray or aerosol formulation specified) CP.0700.040.099. F Cleaning products and household care surface cleaner NOC hard surface and kitchen surface cleaners CP.1700.010.099. F Cleaning products and household care upholstery cleaner NOC upholstery fabric cleaners CP.1800.010.050. F Cleaning products and household care wood polish spray wood or furniture dusting or polishing products (spray or aerosol formulation specified) CP.1800.010.099. F Cleaning products and household care wood polish NOC wood or furniture dusting or polishing products LY.0100.010.040.F Landscape/Yard cleaner exterior exterior surface (e.g. deck, house, driveway) cleaners LY.0600.010.099.F Landscape/Yard garden care NOC miscellaneous garden care products not otherwise characterized (e.g. rooting powders) LY.0600.020.099.F Landscape/Yard garden fertilizer NOC fertilizers for vegetable or flower gardens, including in combination with pest/weed controllers LY.0200.010.099.F Landscape/Yard grill/camping fuel NOC grill, lantern and camping stove fuels, including briquets LY.0300.010.050.F Landscape/Yard herbicide spray herbicides, weed killers, and brush killers (spray or aerosol formulation specified) LY.0300.010.099.F Landscape/Yard herbicide NOC herbicides, weed killers, and brush killers LY.0400.010.099.F Landscape/Yard lawn fertilizer NOC fertilizers for lawns, including in combination with pest/weed controllers LY.0500.010.099.F Landscape/Yard lawnmower fluids NOC oils and other fluids for lawnmowers or other small yard care equipment LY.0600.030.099.F Landscape/Yard mulch NOC mulches, including those with weed controllers LY.0700.010.030.F Landscape/Yard pool chemicals algaeci de algaecide products for pools, hot tubs, and spas LY.0700.010.031.F Landscape/Yard pool chemicals chlorina ting chlorinating products for pools, hot tubs, and spas LY.0700.010.032.F Landscape/Yard pool chemicals PH control pH control products for pools, hot tubs, and spas LY.0700.010.033.F Landscape/Yard pool chemicals shock shock products for pools, hot tubs, and spas LY.0700.010.099.F Landscape/Yard pool chemicals NOC products not otherwise characterized for pools, hot tubs, and spas LY.0600.040.099.F Landscape/Yard potting soil NOC potting soil and vermiculite LY.0800.010.099.F Landscape/Yard surface deicer NOC products for deicing surfaces LY.0600.050.099.F Landscape/Yard trees NOC miscellaneous tree care products including sealers PC.0100.010.050.F Personal care acne spot treatment spray creams and wipes for spot-treating acne (spray or aerosol formulation specified PC.0100.010.099.F Personal care acne spot treatment NOC creams and wipes for spot-treating acne 30 ------- PC.2700.040.099. F Personal care aftershave NOC lotions, balms, liquids, and gels for post-shave applications (usually fragranced) PC.0800.010.001.F Personal care baby lotion child baby cream or lotion (excluding diaper creams) PC.0800.020.001.F Personal care baby oil child skin oils specifically marketed for babies PC.0800.030.001.F Personal care baby powder child powders specifically marketed for babies PC.0800.040.001.F Personal care baby shampoo child shampoos specifically marketed for babies PC.0800.050.001.F Personal care baby wash child body washes and cleaners specifically marketed for babies PC.0800.060.001.F Personal care baby wipes child diaper and other baby wipes PC.0500.010.099.F Personal care bar soap NOC bar and other solid soaps PC.2800.010.099. F Personal care bath oil NOC bath oils or oil-filled beads PC.0800.070.001.F Personal care bath paints/crayons child bath paints or bath crayons PC.2800.020.099. F Personal care bath salts NOC bath salts, soaks, and fizzes PC.0200.010.099.F Personal care bite relief NOC soothing treatments for insect bites PC.2300.010.099. F Personal care blush/bronzer NOC cheek blushes, bronzers, and rouges PC.0300.010.099.F Personal care body adhesive NOC NA PC.0400.010.099.F Personal care body care set NOC multicomponent body care or bath set for which individual products are not designated PC.0600.010.050.F Personal care body oil spray body oils (not including baby or bath oils, spray or aerosol formulation specified) PC.0600.010.099.F Personal care body oil NOC body oils (not including baby or bath oils) PC.0700.010.099.F Personal care body powder NOC talcum and dusting powders for the body PC.0500.020.099.F Personal care body scrub NOC body cleaners containing abrasives or exfoliants PC.0500.030.099.F Personal care body wash NOC body cleaners, washes, shower gels PC.0500.040.099.F Personal care body wipes NOC body wipes and towelettes (excluding diaper or baby wipes) PC.2800.030.099. F Personal care bubble bath NOC bubble baths PC.2700.050.099. F Personal care clipper lubricant/cleaner NOC cleaning and lubricating products for hair clippers PC.1100.020.050. F Personal care contact care spray contact lens cleaners and solutions (spray or aerosol formulation specified) PC.1100.020.099. F Personal care contact care NOC contact lens cleaners and solutions PC.2300.020.099. F Personal care cosmetic tool cleaner NOC NA PC.0900.030.099.F Personal care denture adhesive NOC denture adhesives PC.0900.040.099.F Personal care denture cleaner NOC denture cleansers PC.1000.010.051.F Personal care deodorant gel deodorants and antiperspirants (gel formulation specified) PC.1000.010.056. F Personal care deodorant solid deodorants and antiperspirants (solid formulation specified) 31 ------- PC.1000.010.050. F Personal care deodorant spray deodorants and antiperspirants (spray or aerosol formulation specified) PC.1000.010.099. F Personal care deodorant NOC deodorants and antiperspirants not otherwise characterized PC.2700.060.050. F Personal care depilatory spray chemical products for removal of body or facial hair (spray or aerosol formulation specified) PC.2700.060.099. F Personal care depilatory NOC chemical products for removal of body or facial hair PC.0800.080.001.F Personal care diaper cream child diaper creams and ointments PC.2000.070.050. F Personal care dry shampoo spray dry shampoos for removing hair oils (spray or aerosol formulation specified) PC.2000.070.099. F Personal care dry shampoo NOC dry shampoos for removing hair oils PC.2000.080.099. F Personal care ethnic hair care NOC products for ethnic hair care, including wrap set lotions and pressing lotions (excluding relaxers) PC.1100.030.099. F Personal care eye cream NOC creams and moisturizers for specific treatment of eye area PC.1100.040.099. F Personal care eye drops NOC products for lubricating eyes or treating redness PC.1100.050.050. F Personal care eye lid spray spray NA PC.2300.030.052. F Personal care eye liner liquid eye liners or brow coloring products (liquid or gel formulation specified) PC.2300.030.099. F Personal care eye liner NOC eye liners or brow coloring products PC.2300.040.099. F Personal care eye makeup NOC miscellaneous cosmetic eye products including lash adhesives and tints PC.1100.060.099. F Personal care eye products NOC NA PC.2300.050.099. F Personal care eye shadow NOC products for coloring eye lids PC.1200.010.099. F Personal care face cleansing wipes NOC textile wipes or pads treated with cleansing solution PC. 1200.020.050. F Personal care face cream/moisturizer spray moisturizers, lotions, and creams for primarily treating the face (excluding eye-specific products) (spray or aerosol formulation specified) PC. 1200.020.099. F Personal care face cream/moisturizer NOC moisturizers, lotions, and creams for primarily treating the face (excluding eye-specific products) PC. 1200.030.099. F Personal care face mask NOC leave-on masks or peels for treatment of the face PC.2300.060.099. F Personal care face powder NOC pressed or loose powders for face PC.0100.020.099.F Personal care face scrub NOC facial cleansing products containing exfoliating particles, for acne treatment PC.1200.040.099. F Personal care face scrub NOC facial cleansing products containing exfoliating particles (excluding products for acne) PC.0100.030.099.F Personal care face wash NOC facial cleansing products (excluding scrubs), for acne treatment PC. 1200.050.050. F Personal care face wash spray facial cleansing products (excluding scrubs) (spray or aerosol formulation specified) PC. 1200.050.099. F Personal care face wash NOC facial cleansing products (excluding scrubs and products for acne) PC.1500.010.050. F Personal care foot care spray miscellaneous products for application to feet, including scrubs, lotions, and deodorants (spray or aerosol formulation specified) 32 ------- PC.1500.010.099. F Personal care foot care NOC miscellaneous products for application to feet, including scrubs, lotions, and deodorants PC.2300.070.099. F Personal care foundation/concealer NOC liquid or cream foundation make-ups and concealers PC.1600.010.050. F Personal care fragrance spray fragrances, colognes, and perfumes (spray or aerosol formulation specified) PC.1600.010.099. F Personal care fragrance NOC fragrances, colognes, and perfumes PC.1800.010.099. F Personal care glitter NOC powder products containing reflective particles for face or body PC.1900.010.099. F Personal care hair bleach NOC products for lightening or removing color from hair on the head PC. 1900.030.099. F Personal care hair color - permanent NOC hair colors and dyes characterized as permanent PC.1900.040.099. F Personal care hair color - professional NOC hair colors and dyes characterized as for professional use PC. 1900.050.099. F Personal care hair color - temporary NOC hair colors and dyes characterized as temporary PC. 1900.050.050. F Personal care hair color - temporary spray hair colors and dyes characterized as temporary (spray or aerosol formulation specified) PC. 1900.020.099. F Personal care hair color NOC hair coloring products not otherwise categorized PC.1900.060.099. F Personal care hair color activator NOC chemical activators for hair coloring products PC.1900.070.099. F Personal care hair color developer NOC chemical developers for hair coloring products PC.1900.080.099. F Personal care haircolortoner NOC chemical toners for hair coloring products PC.2000.100.099. F Personal care hair conditioner - leave- in NOC leave-in everyday hair conditioners and detanglers PC.2000.100.050. F Personal care hair conditioner - leave- in spray leave-in everyday hair conditioners (spray or aerosol formulation specified) PC.2000.090.050. F Personal care hair conditioner spray rinse-out everyday hair conditioners (excluding combo shampoo/conditioner products) (spray or aerosol formulation specified) PC.2000.090.099. F Personal care hair conditioner NOC rinse-out everyday hair conditioners (excluding combo shampoo/conditioner products) PC.2000.120.099. F Personal care hair conditioning treatment - professional NOC hair conditioning and moisturizing treatments for occasional use characterized as for professional use PC.2000.110.050. F Personal care hair conditioning treatment spray hair conditioning and moisturizing treatments for occasional use (spray or aerosol formulation specified) PC.2000.110.099. F Personal care hair conditioning treatment NOC hair conditioning and moisturizing treatments for occasional use PC.2000.130.099. F Personal care hair relaxer NOC chemical hair relaxers PC.2000.140.099. F Personal care hair spray NOC spray fixatives for hair PC.2000.160.051.F Personal care hair styling - gel gel hair styling products for hold, shine, or texture (gel formulation indicated) PC.2000.160.057. F Personal care hair styling - gel gel | spr ay hair styling products for hold, shine, or texture (gel and spray formulation indicated) PC.2000.170.058. F Personal care hair styling - mousse mousse foaming hair styling products 33 ------- PC.2000.170.059. F Personal care hair styling - mousse mousse 1 spray NA PC.2000.150.053.F Personal care hair styling powder NA PC.2000.150.050. F Personal care hair styling spray hair styling products for hold, shine, or texture (spray or aerosol formulation specified) PC.2000.150.099. F Personal care hair styling NOC hair styling products for hold, shine, or texture PC.0500.050.050.F Personal care hand sanitizer spray antibacterial products for hands (spray or aerosol formulation specified) PC.0500.050.099.F Personal care hand sanitizer NOC antibacterial products for hands PC.0500.060.099.F Personal care hand soap NOC liquid hand soaps PC.0500.070.099.F Personal care hand wipes NOC wipes and solution primarily for hands PC.1700.010.051.F Personal care hand/body lotion gel lotions and creams primarily for hands and body (gel formulations indicated) PC.1700.010.057. F Personal care hand/body lotion gel | spr ay lotions and creams primarily for hands and body (gel and spray or aerosol formulation specified) PC.1700.010.050. F Personal care hand/body lotion spray lotions and creams primarily for hands and body (spray or aerosol formulation specified) PC.1700.010.099. F Personal care hand/body lotion NOC lotions and creams primarily for hands and body PC.2000.180.099. F Personal care lice shampoo NOC shampoos for the treatment of head lice PC.2200.010.099. F Personal care liniment NOC liniments and ointments for treatment of muscle or joint pain PC.2300.080.099. F Personal care lip balm NOC lip products primarily for protection PC.2300.090.099. F Personal care lip color NOC colored lip products, excluding glosses PC.2300.100.099. F Personal care lip gloss NOC glossy lip products PC.2300.110.099.F Personal care lip liner NOC pencils for lining lips PC.2300.120.099.F Personal care makeup primer NOC products for priming face for make-up PC.2300.130.099.F Personal care makeup remover NOC products for removing face make-ups PC.2300.140.099. F Personal care makeup set NOC multicomponent make-up set for which individual products are not designated PC.2300.150.099.F Personal care mascara NOC eyelash mascaras PC.0900.050.050.F Personal care mouthwash spray antiseptic and dental mouthwashes and rinses (spray or aerosol formulation specified) PC.0900.050.099.F Personal care mouthwash NOC antiseptic and dental mouthwashes and rinses PC.2400.010.099. F Personal care nail adhesive NOC adhesives for repairing fingernails or attaching artificial nails PC.2400.020.099. F Personal care nail polish NOC clear or colored nail enamels, polishes, basecoats, topcoats, and other acrylic coatings PC.2400.030.099. F Personal care nail polish remover NOC products for removing nail polish or artificial nails PC.2400.040.050. F Personal care other nail products spray miscellaneous products for nail or cuticle treatment not otherwise characterized (spray or aerosol formulation specified) 34 ------- PC.2400.040.099. F Personal care other nail products NOC miscellaneous products for nail or cuticle treatment not otherwise characterized PC.2000.190.050. F Personal care scalp treatment spray products for treating the scalp, including products dandruff or hair loss (spray or aerosol formulation specified) PC.2000.190.099. F Personal care scalp treatment NOC products for treating the scalp, including products dandruff or hair loss PC.2500.010.050. F Personal care self-tanner spray chemical products for tanning, staining, or coloring the skin (spray or aerosol formulation specified) PC.2500.010.099. F Personal care self-tanner NOC chemical products for tanning, staining, or coloring the skin PC.2600.010.099. F Personal care sexual wellness NOC sexual wellness products, including personal lubricants PC.2000.200.099. F Personal care shampoo - dandruff NOC shampoos, including dual shampoo/conditioner products for treatment of dandruff PC.2000.210.099. F Personal care shampoo NOC shampoos, including dual shampoo/conditioner products PC.2700.070.051. F Personal care shaving cream gel shaving creams, foams, balms and soaps (gel formulation specified) PC.2700.070.099. F Personal care shaving cream NOC shaving creams, foams, balms and soaps PC.2900.010.050. F Personal care sunscreen spray sunscreens and blocks (spray or aerosol formulations specified) PC.2900.010.001. F Personal care sunscreen child sunscreens and blocks marketed to children or babies PC.2900.010.Oil.F Personal care sunscreen child | spray sunscreens and blocks marketed to children or babies (spray or aerosol formulations specified PC.2900.010.099. F Personal care sunscreen NOC sunscreens and blocks PC.0900.060.099.F Personal care teeth whitener NOC teeth whitening products (excluding toothpastes) PC.2300.160.099. F Personal care toner NOC face and skin toners and astringents PC.0900.070.051.F Personal care toothpaste gel toothpastes and dentifrices (gel formulation specified) PC.0900.070.099.F Personal care toothpaste NOC toothpastes and dentifrices PC.2700.080.099. F Personal care waxing NOC wax products for removing hair from face or body PE.0100.010.050.F Pesticides animal repellent spray chemical animal repellents (spray or aerosol formulation specified) PE.0100.010.099.F Pesticides animal repellent NOC chemical animal repellents PE.0200.010.050. F Pesticides fungicide spray fungicides for garden or home use (spray or aerosol formulation specified) PE.0200.010.099. F Pesticides fungicide NOC fungicides for garden or home use PE.0300.020.099. F Pesticides insect repellent - exterior NOC miscellaneous products for repelling insects, exterior use indicated PE.0300.020.050. F Pesticides insect repellent - exterior spray miscellaneous products for repelling insects, exterior use indicated (spray or aerosol formulation specified) PE.0300.030.099. F Pesticides insect repellent - skin NOC products for repelling insects from skin PE.0300.030.050. F Pesticides insect repellent - skin spray products for repelling insects from skin (spray or aerosol formulation specified) 35 ------- PE.0300.010.050. F Pesticides insect repellent spray miscellaneous products for repelling insects (excluding products to be applied to skin) (spray or aerosol formulation specified) PE.0300.010.099. F Pesticides insect repellent NOC miscellaneous products for repelling insects (excluding products to be applied to skin) PE.0400.020.099. F Pesticides insecticide - exterior NOC insecticides, exterior use indicated - including lawn and gardens PE.0400.020.050. F Pesticides insecticide - exterior spray insecticides, exterior use indicated (spray or aerosol formulation specified) PE.0400.030.099. F Pesticides insecticide - interior NOC insecticides, interior use indicated PE.0400.030.050. F Pesticides insecticide - interior spray insecticides, interior use indicated (spray or aerosol formulation specified) PE.0400.010.050. F Pesticides insecticide spray insecticides not otherwise characterized (spray or aerosol formulation specified) PE.0400.010.099. F Pesticides insecticide NOC insecticides not otherwise characterized PE.0500.010.099. F Pesticides rodenticide NOC rodenticides for interior or exterior use PT.0400.010.099. F Pet care aquarium NOC miscellaneous aquarium treatment products PT.0200.010.099. F Pet care cat litter NOC cat litters PT.0100.060.050. F Pet care other pet treatments spray miscellaneous pet treatments (excluding pesticides) (spray or aerosol formulation specified) PT.0100.060.099. F Pet care other pet treatments NOC miscellaneous pet treatments (excluding pesticides) PT.0100.070.099. F Pet care pesticide - pet NOC pesticides for application to pets PT.0100.070.050. F Pet care pesticide - pet spray pesticides for application to pets (spray or aerosol formulation specified) PT.0100.080.099. F Pet care pet shampoo NOC pet shampoos (including those contain pesticides) PT.0100.090.050. F Pet care pet stain cleaner spray carpet and upholstery cleaners for pet stains (spray or aerosol formulation specified) PT.0100.090.099. F Pet care pet stain cleaner NOC carpet and upholstery cleaners for pet stains 36 ------- Appendix E: Data dictionary for daily dose output variables from Source-to-dose module Variable name Description of Output Variable household Household number from ABM output daynum The number of the day in a year DJXSID DSSTox Chemical ID dir.derm.exp Mass (mg) of chemical on skin from direct product use dir.derm.max Maximum loading (mg/cm2) on either hands or body (direct use) dir.derm.abs Mass (mg) absorbed through skin (direct use) dir.inhal.exp Average air concentration (mg/m3) for primary person (direct) dir.inhal.max Maximum air concentration (mg/m3) (direct) dir.inhal.mass Direct mass inhaled in the day (mg) dir.inhal.abs Mass (mg) absorbed through the lungs (direct use) . Mass (mg) ingested from hand-to-mouth transfer as well as transferred to the gut compartment during dir.ingest.exp ..... ... initial use phase (direct) dir.ingest.abs Mass (mg) absorbed through the gut (direct use) release Mass (mg) of chemical released by product use (primary person) ind.derm.exp Mass (mg) of chemical on skin from indirect exposure ind.derm.max Maximum loading (mg/cm2) on either hands or body (indirect) ind.derm.abs Mass (mg) absorbed through skin (indirect exposure) ind.inhal.exp Average air concentration (mg/m3) for primary person (indirect) ind.inhal.max Maximum air concentration (mg/m3) (indirect) ind.inhal.abs Mass (mg) absorbed through the lungs for (indirect) ind.inhal.mass Indirect mass inhaled in the day (mg) ind.ingest.exp Mass (mg) ingested from hand-to-mouth transfer (indirect) ind.ingest.abs Mass (mg) absorbed through the gut (indirect) out.sur Mass (mg) released to outdoor surfaces (outdoor product use) out.air Mass (mg) released to outdoor air (outdoor use and house losses) drain Mass (mg) going into the drain system (includes chemical in the hair and nail compartments) waste Mass (mg) disposed in trash 37 ------- |