SEPA
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www. e pa .gov/resea rc h
science in ACTION
INNOVATIVE RESEARCH FOR A SUSTAINABLE FUTURE
CHEMICAL SAFETY
for SUSTAINABILITY
Rapid Exposure Modeling & Dosimetry Research Area
Most chemicals in commerce lack vital information to help us understand whether the chemicals we
breathe, eat, drink, and touch may impact our health. EPA's Chemical Safety for Sustainability Research
Program conducts research to model exposure to chemicals and generate dosage information to thoroughly
evaluate potential risks to humans, wildlife, and ecosystems.
EPA's Chemical Safety for Sustainability Research Program
The goal of EPA's Chemical Safety for Sustainability (CSS) National
Research Program is to provide information and methods to make better-
informed, more timely decisions about the safety of chemicals, many of
which have not been thoroughly evaluated for potential risks to human
health and the environment.
About Rapid Exposure Modeling & Dosimetry Research
The Rapid Exposure Modeling & Dosimetry research area focuses on
modeling and forecasting chemical exposures across various scenarios
relevant to human and ecological assessments. This research helps rapidly
generate estimates for exposure and dosage of chemicals, including new
chemicals found in consumer products and the environment.
This research has many goals, including:
•	Addressing gaps in data collection, curation, and modeling needs
•	Creating ways to estimate exposure concentrations at the organ or
individual levels
•	Developing tools to rapidly predict chemical exposure conditions and
estimate human and ecological exposure to chemicals
•	Developing models and tools to address data needs for the
composition and exposure potential of environmental media,
including consumer products.
Why is Rapid Exposure Modeling & Dosimetry
Research Important?
Rapid Exposure Modeling & Dosimetry research provides vital support to
exposure assessments through the development of advanced chemical
monitoring approaches, refinement of exposure pathways and factors,
and high-throughput toxicokinetics to support dosimetry estimates
associated with hazard data.
Interested In Learning More?
EPA's Chemical Safety Research Program: epa.gov/chemical-research
Contact Us:
Jeffrey Frithsen, National Program Director: frithsen. ieff@epa.gov
JoeTietge, Deputy Program Director: tietge.ioePepa.gov
The Question
How are we being exposed to chemicals
in the environment?
Our Rapid Exposure Modeling &
Dosimetry Tools
CompTox Chemicals Dashboard:
dashboard that provides chemistry
data for thousands of chemicals across
EPA's computational research
databases including:
=> CPDat: database containing
information on chemicals in
consumer products
=> ToxCast: high-throughput
screening data

SHEDS: model providing estimates of
exposure to chemicals used in
consumer and in-home products
exposure for thousands of chemicals
1
U.S. Environmental Protection Agency
Office of Research and Development
Last Updated March 2019

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science in ACTION
INNOVATIVE RESEARCH FOR A SUSTAINABLE FUTURE
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Rapid Exposure Modeling & Dosimetry Research Area Up Close
Examples of Research and Products
Visualizing the CSS Program
Our Rapid Exposure Modeling & Dosimetry research is categorized under
the Chemical Evaluation research topic. This topic is dedicated to developing
new and efficient methods to evaluate thousands of chemicals found in
consumer products, the air we breathe, and the water we drink.
How Rapid Exposure Modeling &
Dosimetry Fits In
CSS is organized around three research topics
that address specific science challenges in
assessing the safety of chemicals: Chemical
Evaluation, Complex Systems Science, and
Knowledge Translation & Delivery.
Included in our Chemical Evaluation research
topic, our Rapid Exposure Modeling &
Dosimetry research develops methods to
model and forecast the potential for real-
world human exposure to chemicals,
including those associated with consumer
product use.
U.S. Environmental Protection Agency
Office of Research and Development
I
Application of non-targeted analysis to characterize constituents of
consumer products and articles
=> Description: a dataset providing information on chemical compounds in
consumer products, generated using suspect screening analysis
=> Impact: The quantification of compounds in commonly used products that are
provided by this dataset will provide important parameter estimates for high-
throughput exposure forecasting models developed under the ExpoCast
research effort. This data will also be incorporated into the Chemical and
Products Database, which contains consumer product information.
=> Who Can Use It?: Researchers interested in forecasting exposure or in need of
data on consumer products
=> Learn More: epa.gov/chemical-research/rapid-chemical-exposure-and-dose-
research
Stochastic Human Exposure and Dose Simulation (SHEDS) HT
=> Description: SHEDS-HT is a high-throughput probabilistic model that can quickly
provide human exposure estimates for new chemicals that have limited data and
provide information to help prioritize chemicals for future study on the basis of
risk.
=> Impact: SHEDS models enhance estimates of exposure in many contexts to
inform EPA human health risk assessments and risk management decisions.
=> Who Can Use It?: The SHEDS models can be used by anyone, including
individuals from academia, industry, government, and consulting firms.
=> Learn More: epa.eov/chemical-research/stochastic-human-exposure-and-dose-
simulation-sheds-estimate-human-exposure
Evaluating In Vitro-ln Vivo Extrapolation of Toxicokinetics
=> Description: a journal article published in Toxicological Sciences providing useful
research into understanding the relationship between in vitro bioactivity dose
and external exposure concentration
=> Impact: a recipient of a Toxicological Sciences Editor's Highlight, this article
provides useful information on translating in vitro (cell-based) experiential
results to predict in vivo (animal-based) outcomes
=> Who Can Use It?: everyone, including researchers and risk assessors
=> Learn More: doi.ore/10.1093/toxsci/kfv020
Learn more
EPA's Chemical Safety Research Program: epa.gov/chemical-research
Last Updated March 2019

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