EPA United States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention Final Risk Evaluation for Methylene Chloride Systematic Review Supplemental File: Data Quality Evaluation of Physical-Chemical Property Studies CASRN: 75-09-2 H H .o^CI CI June 2020 ------- Table of Contents U.S. Coast Guard (1984). CHRIS hazardous chemical data. U.S. Department of Transportation. Washington, DC 3 O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry 4 O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry 5 O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry 6 Bauble, T; Fried, V; Hala, E. (1984). The vapour pressures of pure substances: Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region (2nd Revised ed.). Amsterdam, The Netherlands: Elsevier Science Publishers 7 Holbrook, MT. (2003). Methylene chloride. In: Kirk-Othmer Encyclopedia of Chemical Technology, lohn Wiley & Sons, Inc 8 Horvath, AL. (1982). Halogenated hydrocarbons: solubility-miscibility in water. Marcel Dekker, Inc. New York, New York 9 Hansch, C. (1995). Fundamentals and applications in chemistry and biology - hydrophobic, electronic and steric constants. In Exploring QSAR. Washington DC: American Chemical Society Professional Reference Book/Oxford University Press 10 Leighton, DT; Calo, IM. (1981). Distribution coefficients of chlorinated hydrocarbons in dilute air-water systems for groundwater contamination applications 11 Rossberg, M., Lendle, W., Pfleiderer, A., Togel, A. (2011). Chloromethanes. In: Ullmann's Encyclopedia of Industrial Chemicals. Wiley-VCH Verlag GmbH & Co 12 O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry 13 Laurence et al. (1994). The empirical treatment of solvent-solute interactions: 15 years of pi*. I Phys Chem 98: 5807-5816 14 2 ------- Study Reference: U.S. Coast Guard (1984). CHRIS hazardous chemical data. U.S. Department of Transportation. Washington, DC. Note: U.S. Coast Guard (1984) reported the physical form of methylene chloride. Qualitative Determination Domain/Metric Description/ Definition [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment The information or data reflects The information was measured Representativeness the data and chemical substance t\ pe. 1 liuli lor the subject chemical substance The information or data reflects anticipated results based on chemical structural features or behaviors. The information is consistent Appropriateness High with the nature of the substance. The data collection is from a The information known source that lists se\eral Evaluation/ Review or data reported has reliable re\ iew Medium reliable primary sources in its references. 1 lowe\ cr. indi\idual \ allies are not cited to their oriuinal sources The method for Reliability/ Unbiased (Method Objectivity) producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. The information Reliability/ Analytic Method or data reported is from a reliable method Not rated This metric is not applicable to this information type Overall Quality Level High 3 ------- Study Reference: O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry. Note: O'Neil (2013) reported various physical-chemical properties and only the confidence of the boiling point is evaluated. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the dala and chemical substance t\ pe 1 liuli The dala was measured for the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or dala reported has reliable re\ iew 1 liuli The information is from a recognized data collection where data are |">ccr-rc\ iewed by experts in the lield and arc broadly a\ailable to the public for re\ iew and use Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The inlbi'malion or dala reported is from a reliable method 1 .o\\ Data source does not pro\ide information icuardinu the analytical method Overall Quality Level High 4 ------- Study Reference: O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry. Note: O'Neil (2013) reported various physical-chemical properties and only the confidence of the melting point is evaluated. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the dala and chemical substance t\ pe 1 liuli The dala was measured for the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or dala reported has reliable re\ iew 1 liuli The information is from a recognized data collection where data are |">ccr-rc\ iewed by experts in the lield and arc broadly a\ailable to the public for re\ iew and use Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The inlbi'malion or dala reported is from a reliable method 1 .o\\ Data source does not pro\ide information icuardinu the analytical method Overall Quality Level High 5 ------- Study Reference: O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry. Note: O'Neil (2013) reported various physical-chemical properties and only the confidence of the density is evaluated. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the dala and chemical substance t\ pe 1 liuli The dala was measured for the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or dala reported has reliable re\ iew 1 liuli The information is from a recognized data collection where data are |">ccr-rc\ iewed by experts in the lield and arc broadly a\ailable to the public for re\ iew and use Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The inlbi'malion or dala reported is from a reliable method 1 .o\\ Data source does not pro\ide information icuardinu the analytical method Overall Quality Level High 6 ------- Study Reference: Bauble, T; Fried, V; Hala, E. (1984). The vapour pressures of pure substances: Selected values of the temperature dependence of the vapour pressures of some pure substances in the normal and low pressure region (2nd Revised ed.). Amsterdam, The Netherlands: Elsevier Science Publishers. Note: Boublik et al. (1984) reported the vapor pressure of methylene chloride. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data roll eels the data and chemical substance type. 1 ligli The \ a 1 Lie was deri\ ed by interpolation from a peer- rex iew ed set of measured \ apor pressures (Si l)e\ mm 1 lu) Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The value is consistent with the nature of the substance. Kvaluation/ Review The inlbi'malion or data reported has reliable re\ iew 1 liuh The data set has been cited to its original source which is peer-re\ iewed The authors also slate that the quality of the experimental data was considered before its inclusion in the data collection Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The inlbi'malion or data reported is from a reliable method 1 .o\\ Data source does not pro\ide information regarding the analytical method Overall Quality Level High 7 ------- Study Reference: Holbrook, MT. (2003). Methylene chloride. In: Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. Note: Holbrook (2003) reported the vapor density of methylene chloride. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or data reflects the data and chemical substance t\ pe 1 liuli The data was measured lor the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or data reported has reliable re\ iew lliuli The information is from a recognized data collection in which results ha\e been selected by experts based on their quality and a\ailabilit\ References to the oriuinal sources are included Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The information or data reported is from a reliable method 1 .ou Data source does not pro\ide information regarding the analytical method Overall Quality Level High 8 ------- Study Reference: Horvath, AL. (1982). Halogenated hydrocarbons: solubility-miscibility in water. Marcel Dekker, Inc. New York, New York. Note: Horvath (1982) reported the water solubility of methylene chloride. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or dala reflects the dala and chemical substance t\ pe 1 liuh The data was measured lor the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The consistency of the value with data measured for other similar chemicals was considered before its inclusion in the data collection. Evaluation/ Review The information or dala reported has reliable re\ iew 1 liuh The \ alLie is from a dala collection where data were peer- rex iewed. cited to original sources, and had their experimental quality examined before inclusion Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High The method for producing the data is not biased towards a particular outcome. Reliability/ Analytic Method The information or data reported is from a reliable method 1 liuh The data collection only includes \ allies thai ha\e been obtained using reliable and accepted analytical methods Overall Quality Level High 9 ------- Study Reference: Hansch, C. (1995). Fundamentals and applications in chemistry and biology - hydrophobic, electronic and steric constants. In Exploring QSAR. Washington DC: American Chemical Society Professional Reference Book/Oxford University Press. Note: Hansch (1995) reported the Log Kow of methylene chloride. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not rated] Comment Representativeness The information or data reflects the data and chemical substance t\ pe 1 ligli The data was measured lor the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Kvaluation/ Review The information or dala reported has reliable re\ ieu 1 ligli The information is from a recognized data collection that has been compiled by experts and includes references to the original sources The original source for this \ alue is a peer- rex ieued journal Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The information or data reported is from a reliable method 1 .o\\ Data source does not pro\ide information regarding the analytical method Overall Quality Level High 10 ------- Study Reference: Leighton, DT; Calo, JM. (1981). Distribution coefficients of chlorinated hydrocarbons in dilute air-water systems for groundwater contamination applications. Note: Leighton and Calo (1981) reported the Henry's Law constant as a dimensionless value and it has been converted to atm-m3/mol. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or data reflects the data and chemical substance ivpe 1 liuli The \ alnc was measured lor the subject chemical substance Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or data reported has reliable re\ ieu 1 Hull The source is a peer-re\ ieued journal Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High The method for producing this value is not biased towards a particular outcome. Reliability/ Analytic Method The information or data reported is from a reliable method 1 liuli The analytical method used to measure this \alue is an accepted standard method. Overall Quality Level High 11 ------- Study Reference: Rossberg, M., Lendle, W., Pfleiderer, A., Togel, A. (2011). Chloromethanes. In: Ullmann's Encyclopedia of Industrial Chemicals. Wiley-VCH Verlag GmbH & Co. Note: Rossberg et al. (2011) reported the viscosity of methylene chloride Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or data reflects the data and chemical substance ivpe. 1 liuli The \alue was measured lor the subject chemical substance Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The value was similar to measured values for chemicals of similar structure. Evaluation/ Review The information or data reported has reliable re\ iew 1 Hull The \alue was from a peer- rex iewed source Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The information or data reported is from a reliable method 1 .ou Data source does not pro\ide information reuardinu the analytical method Overall Quality Level High 12 ------- Study Reference: O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry. Note: O'Neil (2013) reported various physical-chemical properties and only the confidence of the refractive index is evaluated. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or data reflects the data and chemical substance t\ pe Midi The data was measured for the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The measured value is consistent with the nature of the substance. Evaluation/ Review The information or data reported has reliable re\ iew 1 Hull The information is from a recognized data collection where data are |")eer-re\ iew ed by experts in the field and are broadly a\ ailable to the public lor re\ iew and use Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. Not rated Data source does not provide information to determine the method objectivity (unbiased method). Thus, the domain/metric was not rated. Reliability/ Analytic Method The information or data reported is from a reliable method 1 .o\\ Data source does not pro\ide information reuardinu the analytical method Overall Quality Level High 13 ------- Study Reference: Laurence et al. (1994). The empirical treatment of solvent-solute interactions: 15 years of pi*. J Phys Chem 98: 5807-5816. Note: Laurence et al. (1994) reported the dielectric constant of methylene chloride. Domain/Metric Description/ Definition Qualitative Determination [i.e., High, Medium, Low, Unacceptable, or Not ratedl Comment Representativeness The information or data reflects the data and chemical substance t\ pe 1 liuli The \ allic was measured lor the substance of interest Appropriateness The information or data reflects anticipated results based on chemical structural features or behaviors. High The value was similar to those measured for structurally similar compounds. Evaluation/ Review The information or data reported has reliable re\ iew 1 liuli The information is from a peer- rex iewed journal Reliability/ Unbiased (Method Objectivity) The method for producing the data/information is not biased towards a particular product or outcome. High The methodology for producing the information is designed to answer a specific question. Reliability/ Analytic Method The information or data reported is from a reliable method 1 liuli The \alue was obtained by an accepted standard analytical method Overall Quality Level High 14 ------- |