EPA
United States	Office of Chemical Safety and
Environmental Protection Agency	Pollution Prevention
Final Risk Evaluation for
Methylene Chloride
Systematic Review Supplemental File:
Data Quality Evaluation of Physical-Chemical Property Studies
CASRN: 75-09-2
H
H
.o^CI
CI
June 2020

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Table of Contents
U.S. Coast Guard (1984). CHRIS hazardous chemical data. U.S. Department of Transportation.
Washington, DC	3
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI
O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry	4
O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI
O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry	5
O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI
O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry	6
Bauble, T; Fried, V; Hala, E. (1984). The vapour pressures of pure substances: Selected values of the
temperature dependence of the vapour pressures of some pure substances in the normal and low pressure
region (2nd Revised ed.). Amsterdam, The Netherlands: Elsevier Science Publishers	7
Holbrook, MT. (2003). Methylene chloride. In: Kirk-Othmer Encyclopedia of Chemical Technology,
lohn Wiley & Sons, Inc	8
Horvath, AL. (1982). Halogenated hydrocarbons: solubility-miscibility in water. Marcel Dekker, Inc.
New York, New York	9
Hansch, C. (1995). Fundamentals and applications in chemistry and biology - hydrophobic, electronic and
steric constants. In Exploring QSAR. Washington DC: American Chemical Society Professional
Reference Book/Oxford University Press	10
Leighton, DT; Calo, IM. (1981). Distribution coefficients of chlorinated hydrocarbons in dilute air-water
systems for groundwater contamination applications	11
Rossberg, M., Lendle, W., Pfleiderer, A., Togel, A. (2011). Chloromethanes. In: Ullmann's Encyclopedia
of Industrial Chemicals. Wiley-VCH Verlag GmbH & Co	12
O'Neil, MI. (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals. In MI
O'Neil (Ed.), (15th ed.). Cambridge, UK: Royal Society of Chemistry	13
Laurence et al. (1994). The empirical treatment of solvent-solute interactions: 15 years of pi*. I Phys
Chem 98: 5807-5816	 14
2

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Study Reference:
U.S. Coast Guard (1984). CHRIS hazardous chemical data. U.S.
Department of Transportation. Washington, DC.
Note:
U.S. Coast Guard (1984) reported the physical form of methylene
chloride.


Qualitative



Determination

Domain/Metric
Description/
Definition
[i.e., High,
Medium, Low,
Unacceptable, or
Not rated]
Comment

The information



or data reflects

The information was measured
Representativeness
the data and
chemical
substance t\ pe.
1 liuli
lor the subject chemical
substance

The information



or data reflects



anticipated
results based on
chemical
structural
features or
behaviors.

The information is consistent
Appropriateness
High
with the nature of the
substance.



The data collection is from a

The information

known source that lists se\eral
Evaluation/ Review
or data reported
has reliable
re\ iew
Medium
reliable primary sources in its
references. 1 lowe\ cr.
indi\idual \ allies are not cited
to their oriuinal sources

The method for


Reliability/
Unbiased (Method
Objectivity)
producing the
data/information
is not biased
towards a
particular
product or
outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.

The information


Reliability/
Analytic Method
or data reported
is from a reliable
method
Not rated
This metric is not applicable to
this information type
Overall Quality Level
High
3

-------
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals,
drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK:
Royal Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only
the confidence of the boiling point is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium, Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the
dala and chemical
substance t\ pe
1 liuli
The dala was measured for the
substance of interest
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features
or behaviors.
High
The measured value is
consistent with the nature of
the substance.
Evaluation/ Review
The information or
dala reported has
reliable re\ iew
1 liuli
The information is from a
recognized data collection
where data are |">ccr-rc\ iewed
by experts in the lield and arc
broadly a\ailable to the public
for re\ iew and use
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards
a particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The inlbi'malion or
dala reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information icuardinu the
analytical method
Overall Quality Level
High
4

-------
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals,
drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK:
Royal Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only
the confidence of the melting point is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium, Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the
dala and chemical
substance t\ pe
1 liuli
The dala was measured for the
substance of interest
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features
or behaviors.
High
The measured value is
consistent with the nature of
the substance.
Evaluation/ Review
The information or
dala reported has
reliable re\ iew
1 liuli
The information is from a
recognized data collection
where data are |">ccr-rc\ iewed
by experts in the lield and arc
broadly a\ailable to the public
for re\ iew and use
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards
a particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The inlbi'malion or
dala reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information icuardinu the
analytical method
Overall Quality Level
High
5

-------
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals,
drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK:
Royal Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only
the confidence of the density is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium, Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data reflects the
dala and chemical
substance t\ pe
1 liuli
The dala was measured for the
substance of interest
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features
or behaviors.
High
The measured value is
consistent with the nature of
the substance.
Evaluation/ Review
The information or
dala reported has
reliable re\ iew
1 liuli
The information is from a
recognized data collection
where data are |">ccr-rc\ iewed
by experts in the lield and arc
broadly a\ailable to the public
for re\ iew and use
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards
a particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The inlbi'malion or
dala reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information icuardinu the
analytical method
Overall Quality Level
High
6

-------
Study Reference:
Bauble, T; Fried, V; Hala, E. (1984). The vapour pressures of pure
substances: Selected values of the temperature dependence of the
vapour pressures of some pure substances in the normal and low
pressure region (2nd Revised ed.). Amsterdam, The Netherlands:
Elsevier Science Publishers.
Note:
Boublik et al. (1984) reported the vapor pressure of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium, Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information or
data roll eels the
data and chemical
substance type.
1 ligli
The \ a 1 Lie was deri\ ed by
interpolation from a peer-
rex iew ed set of measured
\ apor pressures (Si l)e\
mm 1 lu)
Appropriateness
The information or
data reflects
anticipated results
based on chemical
structural features
or behaviors.
High
The value is consistent with
the nature of the substance.
Kvaluation/ Review
The inlbi'malion or
data reported has
reliable re\ iew
1 liuh
The data set has been cited to
its original source which is
peer-re\ iewed The authors
also slate that the quality of the
experimental data was
considered before its inclusion
in the data collection
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information is
not biased towards
a particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The inlbi'malion or
data reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information regarding the
analytical method
Overall Quality Level
High
7

-------
Study Reference:
Holbrook, MT. (2003). Methylene chloride. In: Kirk-Othmer
Encyclopedia of Chemical Technology. John Wiley & Sons, Inc.
Note:
Holbrook (2003) reported the vapor density of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or data reflects
the data and
chemical
substance t\ pe
1 liuli
The data was measured lor the
substance of interest
Appropriateness
The information
or data reflects
anticipated
results based on
chemical
structural
features or
behaviors.
High
The measured value is consistent
with the nature of the substance.
Evaluation/ Review
The information
or data reported
has reliable
re\ iew
lliuli
The information is from a
recognized data collection in
which results ha\e been selected
by experts based on their quality
and a\ailabilit\ References to the
oriuinal sources are included
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular
product or
outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the domain/metric
was not rated.
Reliability/
Analytic Method
The information
or data reported
is from a reliable
method
1 .ou
Data source does not pro\ide
information regarding the
analytical method
Overall Quality Level
High
8

-------
Study Reference:
Horvath, AL. (1982). Halogenated hydrocarbons: solubility-miscibility
in water. Marcel Dekker, Inc. New York, New York.
Note:
Horvath (1982) reported the water solubility of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or dala reflects
the dala and
chemical
substance t\ pe
1 liuh
The data was measured lor the
substance of interest
Appropriateness
The information
or data reflects
anticipated
results based on
chemical
structural
features or
behaviors.
High
The consistency of the value with
data measured for other similar
chemicals was considered before
its inclusion in the data collection.
Evaluation/ Review
The information
or dala reported
has reliable
re\ iew
1 liuh
The \ alLie is from a dala
collection where data were peer-
rex iewed. cited to original
sources, and had their
experimental quality examined
before inclusion
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular
product or
outcome.
High
The method for producing the
data is not biased towards a
particular outcome.
Reliability/
Analytic Method
The information
or data reported
is from a reliable
method
1 liuh
The data collection only includes
\ allies thai ha\e been obtained
using reliable and accepted
analytical methods
Overall Quality Level
High
9

-------
Study Reference:
Hansch, C. (1995). Fundamentals and applications in chemistry and
biology - hydrophobic, electronic and steric constants. In Exploring
QSAR. Washington DC: American Chemical Society Professional
Reference Book/Oxford University Press.
Note:
Hansch (1995) reported the Log Kow of methylene chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium, Low,
Unacceptable,
or Not rated]
Comment
Representativeness
The information
or data reflects the
data and chemical
substance t\ pe
1 ligli
The data was measured lor the
substance of interest
Appropriateness
The information
or data reflects
anticipated results
based on chemical
structural features
or behaviors.
High
The measured value is
consistent with the nature of
the substance.
Kvaluation/ Review
The information
or dala reported
has reliable
re\ ieu
1 ligli
The information is from a
recognized data collection that
has been compiled by experts
and includes references to the
original sources The original
source for this \ alue is a peer-
rex ieued journal
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The information
or data reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information regarding the
analytical method
Overall Quality Level
High
10

-------
Study Reference:
Leighton, DT; Calo, JM. (1981). Distribution coefficients of
chlorinated hydrocarbons in dilute air-water systems for groundwater
contamination applications.
Note:
Leighton and Calo (1981) reported the Henry's Law constant as a
dimensionless value and it has been converted to atm-m3/mol.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or data reflects
the data and
chemical
substance ivpe
1 liuli
The \ alnc was measured lor the
subject chemical substance
Appropriateness
The information
or data reflects
anticipated
results based on
chemical
structural
features or
behaviors.
High
The measured value is consistent
with the nature of the substance.
Evaluation/ Review
The information
or data reported
has reliable
re\ ieu
1 Hull
The source is a peer-re\ ieued
journal
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular
product or
outcome.
High
The method for producing this
value is not biased towards a
particular outcome.
Reliability/
Analytic Method
The information
or data reported
is from a reliable
method
1 liuli
The analytical method used to
measure this \alue is an accepted
standard method.
Overall Quality Level
High
11

-------
Study Reference:
Rossberg, M., Lendle, W., Pfleiderer, A., Togel, A. (2011).
Chloromethanes. In: Ullmann's Encyclopedia of Industrial Chemicals.
Wiley-VCH Verlag GmbH & Co.
Note:
Rossberg et al. (2011) reported the viscosity of methylene chloride
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or data reflects
the data and
chemical
substance ivpe.
1 liuli
The \alue was measured lor the
subject chemical substance
Appropriateness
The information
or data reflects
anticipated
results based on
chemical
structural
features or
behaviors.
High
The value was similar to
measured values for chemicals of
similar structure.
Evaluation/ Review
The information
or data reported
has reliable
re\ iew
1 Hull
The \alue was from a peer-
rex iewed source
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular
product or
outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the domain/metric
was not rated.
Reliability/
Analytic Method
The information
or data reported
is from a reliable
method
1 .ou
Data source does not pro\ide
information reuardinu the
analytical method
Overall Quality Level
High
12

-------
Study Reference:
O'Neil, MJ. (2013). The Merck index: An encyclopedia of chemicals,
drugs, and biologicals. In MJ O'Neil (Ed.), (15th ed.). Cambridge, UK:
Royal Society of Chemistry.
Note:
O'Neil (2013) reported various physical-chemical properties and only
the confidence of the refractive index is evaluated.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or data reflects
the data and
chemical
substance t\ pe
Midi
The data was measured for the
substance of interest
Appropriateness
The information
or data reflects
anticipated results
based on
chemical
structural features
or behaviors.
High
The measured value is consistent
with the nature of the substance.
Evaluation/ Review
The information
or data reported
has reliable
re\ iew
1 Hull
The information is from a
recognized data collection where
data are |")eer-re\ iew ed by experts
in the field and are broadly
a\ ailable to the public lor re\ iew
and use
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular product
or outcome.
Not rated
Data source does not provide
information to determine the
method objectivity (unbiased
method). Thus, the
domain/metric was not rated.
Reliability/
Analytic Method
The information
or data reported is
from a reliable
method
1 .o\\
Data source does not pro\ide
information reuardinu the
analytical method
Overall Quality Level
High
13

-------
Study Reference:
Laurence et al. (1994). The empirical treatment of solvent-solute
interactions: 15 years of pi*. J Phys Chem 98: 5807-5816.
Note:
Laurence et al. (1994) reported the dielectric constant of methylene
chloride.
Domain/Metric
Description/
Definition
Qualitative
Determination
[i.e., High,
Medium,
Low,
Unacceptable,
or Not ratedl
Comment
Representativeness
The information
or data reflects
the data and
chemical
substance t\ pe
1 liuli
The \ allic was measured lor the
substance of interest
Appropriateness
The information
or data reflects
anticipated results
based on
chemical
structural features
or behaviors.
High
The value was similar to those
measured for structurally similar
compounds.
Evaluation/ Review
The information
or data reported
has reliable
re\ iew
1 liuli
The information is from a peer-
rex iewed journal
Reliability/
Unbiased (Method
Objectivity)
The method for
producing the
data/information
is not biased
towards a
particular product
or outcome.
High
The methodology for producing
the information is designed to
answer a specific question.
Reliability/
Analytic Method
The information
or data reported is
from a reliable
method
1 liuli
The \alue was obtained by an
accepted standard analytical
method
Overall Quality Level
High
14

-------