August 2017
Office of Chemical Safety and
Pollution Prevention
U.S. EPA
Preliminary Information on Manufacturing, Processing,
Distribution, Use and Disposal:
2f4f6-Tris(tert-butyl)phenol
CASRN: 732-26-3
August 2017
Support document
For Docket EPA-HQ-OPPT-2016-0734
Page 1 of 18

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This document provides a preliminary public summary of available information collected by EPA's
Office of Pollution Prevention and Toxics (OPPT) in the Office of Chemical Safety and Pollution
Prevention (OCSPP) on the manufacturing (including importing), processing, distribution in commerce,
use, and disposal of this chemical. This is based on existing data available to EPA, including information
collected under the Chemical Data Reporting rule, Toxics Release Inventory (if available), information
from other Agency databases, other U.S. Government agencies, publicly available information from
states, and a review of published literature. In addition, the document includes information reported
to EPA by producers and users of the chemical in the United States and in other countries.
This preliminary use information and any additional use information received in the docket by
December 9, 2017, will inform efforts to identify, under section 6(h)(1)(B) of the Toxic Substances
Control Act (TSCA), whether exposure to this chemical is likely, under the conditions of use, either to
the environment, the general population, or to a potentially exposed or susceptible subpopulation
identified by EPA. The information will also inform any risk management efforts following the
exposure and use assessment under TSCA section 6(h)(1)(B).
Mention of trade names in this document does not constitute endorsement by EPA. To verify products
or articles containing this chemical currently in commerce, EPA has identified several examples. Any
lists are provided for informational purposes only. EPA and its employees do not endorse any of the
products or companies.
This document does not contain confidential business information (CBI).
Page 2 of 18

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TABLE OF CONTENTS
CONTACT	3
MANUFACTURING, PROCESSING, DISTRIBUTION, USE, AND DISPOSAL	4
1.	Manufacturing (Including Importing)	4
2.	Processing	5
3.	Products and Articles	5
4.	Distribution (Includes Retailers)	7
5.	Uses 	11
6.	Disposal of Waste and Recycling/Recovery	14
USEFUL TYPES OF INFORMATION	14
APPENDIX: SOURCES CONSULTED	15
CONTACT
Todd Coleman, National Program Chemicals Division, Office of Pollution Prevention and Toxics. 202-
564-1208, Coleman.Todd@epa.gov
Peter Gimlin, National Program Chemicals Division, Office of Pollution Prevention and Toxics. 202-566-
0515, Gimlin.Peter@epa.gov
Docket: EPA-HQ-OPPT-2016-0734
Page 3 of 18

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MANUFACTURING, PROCESSING, DISTRIBUTION, USE, AND DISPOSAL
1. Manufacturing (Including Importing)
For the 2016 Chemical Data Reporting (CDR) period, data reported indicate that there is one company
manufacturing or importing 2,4,6-TTBP in the United States 1,2. The volume of 2,4,6-TTBP
manufactured was claimed as confidential business information (CBI).
There is no Toxics Release Inventory (TRI) data available for this chemical as it is not required to be
reported under TRI.
PubChem reported that in 2006, 2,4,6-TTBP was produced in a production range between 10 and less
than 50 million pounds3.
According to the EPA's 2009 Screening-Level Hazard Characterization - Alkylphenols Category 2,4,6-
TTBP had an aggregate production and/or import volume in the U.S. of between 10 million and 50
million pounds4.
Manufacturing Process
2,4,6-TTBP has been listed as an impurity in 2,6-di-tert-butylphenol and may be a byproduct in the
manufacture of 4-tert-butylphenol5.
2,4,6-TTBP can also be obtained from 2,4-di-tert-butylphenol; 4-tert-butylphenol; and 2-tert-
butylphenol at different proportions given specific reaction conditions. 3-tert-butylphenol can also be
obtained from mixtures containing 2,4,6-TTBP and other phenols6.
Manufacturers (including importers) are required to report under CDR if they meet certain production volume thresholds,
generally 25,000 lb or more of a chemical substance at any single site. Reporting is triggered if the annual reporting
threshold is met during any of the calendar years since the last principal reporting year. In general, the reporting threshold
remains 25,000 lb per site. However, a reduced reporting threshold (2,500 lb) now applies to chemical substances subject
to certain TSCA actions, https://www.epa.gov/chemical-data-reporting/how-report-under-chemical-data-reporting
2	Manufacture means to manufacture, produce, or import for commercial purposes. Manufacture includes the extraction,
for commercial purposes, of a component chemical substance from a previously existing chemical substance or complex
combination of chemical substances. (40 CFR 711.3)
epa.gov/sites/production/files/2015-12/documents/cdr fact sheet importers final dec2015 O.pdf2
3	National Institutes of Health, PubChem Database, https://pubchem.ncbi.nlm.nih.gOv/compound/2 4 6-Tri-tert-
butvlphenol#section=Top (accessed December 20, 2016)
4	U.S. EPA. 2009. Screening-Level Hazard Characterization (Alkylphenols Category),
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.175.5613&rep=repl&type=pdf
5	Convention for the Protection of the Marine Environment of the North Atlantic (OSPAR), 2,4,6-tri-tert-butylphenol,
(OSPAR Commission, 2006 update) 274/2006, http://www.ospar.org/documents?v=6977
6	Fiege, H., Voges, H. W., Hamamoto, T., et al. 2000. Phenol Derivatives. Ullmanns Encyclopedia of Industrial Chemistry.
Page 4 of 18

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2. Processing
For the 2016 CDR period, data reported indicate that this chemical is processed7 for thefollowing:
•	As a reactant or intermediate in the following sectors:
o Basic organic chemical manufacturing
•	Both commercial and consumer uses were reported in the category:
o Fuels and related products.
2,4,6-TTBP has been noted by the National Library of Medicine in ToxNet as the starting material for
the synthesis of 2,6-di-tert-butyl-4-methoxyphenol, which is noted as a powerful antioxidant8.
3. Products and Articles
A 1995 U.S. Patent Number 5,399,275 by the Lubrizol Corporation notes the use of 2,4,6-TTBP at a
concentration of 15% under the category: "environmentally friendly viscosity index improving
compositions". Lubrizol Corporation was noted as a holder of patents that use the Isonox 133 chemical
at different concentrations in their manufactured products9.
2,4,6-TTBP is mentioned in 1,829 additional patents according to NIH's PubChem10.
EPA identified the following types of products based on a search of available sources for products
containing 2,4,6-TTBP. EPA and its employees do not endorse any of the products or companies.
Table 1. List of Products
Trade Name
Use of product
% by weight of
chemical
Link to references, SDS or industry
information
Ethanox 4760E
Automotive
5.5%
http://www.sfm.state.or.us/CR2K SubDB/MS
DS/ETHANOX 4760 E.PDF
Arctic Cat Fuel Injector
Cleaner
Automotive
<0.1%
http://arcticcatlubricants.com/wp-
content/uploads/2014/04/10144-Arctic-Cat-
Fuel-lnjector-Cleaner-07092015.pdf
Tolad 3915
Automotive;
Industrial
10-30%
http://hazard.com/msds/f2/clc/clcxv.html

7	The term "process" means the preparation of a chemical substance or mixture, after is manufacture, for distribution in
commerce—
•	in the same form or physical state as, or in a different form or physical state from, that in which it was received by the
person so preparing such substance or mixture, or
•	as part of an article containing the chemical substance or mixture.
http://uscode.house.gov/view. xhtml?path=/prelim(5)titlel5/chapter53&edition=prelim
8	U.S. National Institutes of Health ToxNet Toxicology Data Network, https://toxnet.nlm.nih.gov/cgi-
bin/sis/search2/r?dbs+hsdb:(5)term+(5)rn+(5)rel+732-26-3 (accessed December 20, 2016)
9	Lange, R. M., Seebauer, J. G., and Mamajek, C. A. (1995). Environmentally Friendly Viscosity Index Improving
Compositions. U.S. Patent 5,399,275, filed Dec. 10,1993 and issued Mar. 21,1995,
https://www.google.com/patents/US53992757chen
10	National Institutes of Health, PubChem Database - Patents,
https://pubchem.ncbi.nlm.nih.gov/compound/12902#section=Patents (accessed December 20, 2016)
Page 5 of 18

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Trade Name
Use of product
% by weight of
chemical
Link to references, SDS or industry
information
BG CF5 Fuel Supplement
Automotive
0.1-1%
https://www.amazon.com/BG%ADCF5%ADFu
el%ADSystem%ADTreatment/dp/B005GDZPCY
Regular Unleaded Petrol
Automotive
*concentration
s above the
limit of
detection
http://caltex.co.nz/resources/msds/

Casite Injector
Sting/Complete Fuel System
Cleaner
Automotive
<1%
http://mvmotorhonev.com/wp-
content/uploads/2016/04/C175-12 C177-
12 Casite-lniector-Sting-Complete-Fuel-
System-Cleaner.pdf
CHAMPION ฎ Fuel Stabilizer
Automotive
0-3%
http://championbrands.com/MSDS/4205M-
Champion%20Fuel%20Stabilizer%20MSDS.pdf
CHAMPION ฎ Engine Oil
Additive
Automotive
<1%
http://www.championbrands.com/MSDS/BT-
engine-protect.pdf
Max 44E
Automotive
<0.1%
http://msdsdigital.com/max-44e-msds
Fuel Stabilizer
Automotive
<0.018%
http://cvclo.com/wp-
content/uploads/2015/12/C290-
C292 SDS Mav2014.pdf
Marine Fuel Stabilizer
Automotive;
Marine
0.02%
http://msds.rowleys.com/cm5210.pdf

lonol BF 200
Antioxidant
<20%
http://www.ingurumena.eiev.euskadi.eus/r49
564/es/contenidos/informacion/planta biodi
esel Puerto bilbao/es 13530/adiuntos/1005
9-AAI-AnexoA-GV-Nov2005.pdf
1170 Power Stroker
Automotive
<0.5%
http://wcs.mi.safeschoolssds.com/document/
repo/5855ad74-748f-lldf-9b6e-
d8d230712f36
Eurol SR 2000 Road Racing
Automotive
0s-
1
1
1
o
http://www.eurol.com/en/productfiles/85914
-en el28906 eurol-sr-2000-road-
racing sds eurol 11.html
Briggs and Stratton Fuel Fit
Automotive;
Industrial
Not reported
http://www.centralspares.co.uk/files/downlo
ads/BS992380%20Briggs%20and%20Stratton
%20fuel%20fit.pdf
Octamar LI-5 Plus
Automotive
0.09-0.99%
https://www.fuelcare.com/pdf/octamarmsds.
pdf
WERCS Sta-Bil Fuel Stabilizer
Automotive;
Marine
3% (Isonox 133
mixture)
http://www.homedepot.com/catalog/pdflma
ges/a6/a6e7aabl-al83-46c9-a3c6-
f590e516a377.pdf
Duradฎ AX22 Liquid Phenolic
Antioxidant
Automotive;
Industrial
Not reported
http://lpa.com.mx/pdf/Durad%20AX22.pdf

McCullock Fuel Stabiliser
Automotive;
Industrial
>0.25 - <1%
http://www.mcculloch.com/ddoc/MCCE/MCC
E2015 AAen/MCCE2015 AAen McCulloch%2
0Fuel%20Stabiliser .pdf
Total Fuel System Cleaner
Automotive
<1%
http://www.hvperlube.com/c3/total-fuel-
system-cleaner-c9.html
STOK9
Automotive
<1%
http://www.champ-
energie.fr/sites/default/files/fds stok9 vs3.1
fr.pdf
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Trade Name
Use of product
% by weight of
chemical
Link to references, SDS or industry
information
Mile Hi
Automotive
Not Reported
http://www.conncoll.edu/media/website-
media/offices/ehs/envhealthdocs/Mile-Hi.pdf
http://www. certifiedlabs.com/certified/Drodu
ctView bvName.asp?countrv=USA&language=
&language id=4&product cat=name&product
cat desc=Products+Bv+Name&pName=MILE
+HI+RTU
Antioxidant No. 37 (AO-37)
Automotive;
Aviation
15%
http://www.certifiedlabs.com/certified/produ
ctView bvName.asp?countrv=USA&language=
&language id=4&product cat=name&product
cat desc=Products+Bv+Name&pName=MILE
+HI+RTU
Jet Fuel JET A-l
Automotive;
Aviation
0-0.0031%
http://www.orlenlietuva.lt/EN/ForBusiness/Pr
oducts/Documents/JET%20A-
1%20%20MSDS%20%202016%20%200RLEN%
20%20Lietuva%20 en.pdf
Carburetor and fuel injector
cleaner
Automotive
0s-
1
1
1
o
https://rislone.com/ca/wp-
content/uploads/2015/04/34705-SDS.pdf
Fuel Injector Cleaner
Automotive
<2.5%
https://rislone.com/sv/wp-
content/uploads/2016/03/51701-51732-
English-SDS.pdf
Rislone ฎ Fuel Injector Cleaner
with Upper Cylinder Lubricant
Automotive
<3%
https://www.whatsinproducts.com/files/bran
ds pdf/1396211702.pdf
Yinox 333
Coating
Not reported
http://www.seechem.com/catalogue m.pdf
6729 Concentrate for low
sulfur fuel oil
Automotive;
Industrial
0s-
1
1
1
o
http://images.raiffeisen.com/Raicom/sdb/444
/aral konzentrat schwefelarmes heizoel d.p
df
Isonox 133
Chemical
Intermediate
20% mixture of
732-26-3 and 2-
(1,1-
dimethylethyl)p
henol
Schenectady Chemicals, Inc. Section 8(e)
Coordinator (CAP Agreement). ISONOX 133
February 25,1992, Public Docket Number
8EHQ-0292-2314
LGEM 2
Lubricating
Grease
0.1-1%
http://www.skf.com/us/products/lubrication-
solutions/lubricants/safetv-data-
sheets/index.html
TY26275 (Gasoline Storage
Stabilizer)
Automotive
<5%
http://www.greenpartstore.com/assets/imag
es/bulletins/2011/tv26275 msds.pdf
RAO-038
Analytical
Standard
NL
http://siri.org/msds/fl/bvk/bvkag.html
Diesel Fuel Stabiliser
Automotive;
Industrial
0.1-1%
http://msdsdigital.com/svstem/files/DIESEL F
UEL STABILISER English.pdf
4. Distribution (Includes Retailers)
General internet searches for distributors of 2,4,6-TTBP in raw form yielded many vendors selling
various quantities (i.e., between one milligram and 9071.85 kilograms) at different purities (i.e.,
between 90% and 99%). Note that these are defined as distributors due to their marketing of 2,4,6-
TTBP for sale and distribution; however, many may also be the manufacturers of 2,4,6-TTBP. Table 2
Page 7 of 18

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below illustrates the identified distributors of 2,4,6-TTBP in raw form. This list is provided for
informational purposes only. EPA and its employees do not endorse any of the products or companies.
Table 2. List of Distributors
Given Name
Available
Quantities
Purity (%)
Reference
2,4,6-tris(tert-
butyl)phenol
VQ
96%
http://www.abcr.de/shop/en/2-4-6-Tri-tert-butvl-phenol-
96.html/
2,4,6-tris(tert-
butyl)phenol
5 to 500 grams
UP
https://orderbb.emolecules.com/search/#?querv=732-26-
3&system-type=BB&p=l
2,4,6-tris(tert-
butyl)phenol
1 to 1,000 gram
package
97%
http://www.amadischem.com/en/198540.htm
2,4,6-tris(tert-
butyl)phenol
VQ
98%
http://ahhchemical.com/search.shtml
2,4,6-tris(tert-
butyl)phenol
VQ
98%
https://aksci.com/item detail.php?cat=P329
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://akoscompounds.de/catalogue/akossampleretrieval-
s.php?IDNUMBERS=AKOS002268919&TERM-732-26-
3&CIDcount+l
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.ambitner.com/reference/2543595
2,4,6-tris(tert-
butyl)phenol
1 to 100 grams
95%
http://www.acccorporation.com/products/CHM0007865
2,4,6-tris(tert-
butyl)phenol
25 to 500 grams
UP
https://chem-space.com/search/58582eb3-2a8cf8-al5015b-
df81da0/CSC000068363.html?currencv=usd
https://orderbb.emolecules.com/search/#?auerv=732-26-
3&system-type=BB&p=l
2,4,6-tris(tert-
butyl)phenol
VQ
97%
http://aokchem.com/aokdetail.php7id-8866
2,4,6-tris(tert-
butyl)phenol
100 grams
95%
http://www.arkpharminc.com/product/detail/AK114270.html


2,4,6-tris(tert-
butyl)phenol
25 to 100 grams
92 to 95%
http://online.aurorafinechemicals.com/StrSearch-new.asp
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.bepharm.com/web/en/product/pro item.aspx?id
=B66408
2,4,6-tris(tert-


http://www.bidepharmatech.com/en/product/detail/BD66408
butyl)phenol
100 grams
95+/-%
.html https://orderbb.emolecules.com/search/#?querv=732-
26-3&system-type=BB&p=l
2,4,6-tris(tert-
butyl)phenol
VQ
UP
https://www.biosvnth.com/products/organic-svnthesis/basic-
intermediates/products/W-104462. html
2,4,6-tris(tert-
butyl)phenol
25 to 500 grams
UP
https://chem-space.com/search/58582eb3-2a8cf8-al5015b-
df81da0/CSC000068363.html?currencv=usd
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.chembopharma.com/product/65415.html
2,4,6-tris(tert-
butyl)phenol
VQ
Distributor of
Angene, Ark
Pharm,and
Biocore
products
https://chem-space.com/search/58582eb3-2a8cf8-al5015b-
df81da0/CSC000068363.html?currencv=usd
2,4,6-tris(tert-
butyl)phenol
5 to 1,000
grams
98%
http://www.combi-blocks.com/cgi-bin/find.cgi7QB-5132
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Given Name
Available
Quantities
Purity (%)
Reference
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://discofinechem.com/products/246-tri-tert-butvlphenol/

2,4,6-tris(tert-
butyl)phenol
25 to 500 grams
UP
http://product.b2star.com/192163.htm
2,4,6-tris(tert-
butyl)phenol
VQ
Distributor of
Acros, Angene,
Ark, Bide,
Combi-Blocks,
Manchester
Organics,
Matrix
Scientific,
OxChem, TCI
America
https://orderbb.emolecules.com/search/#?querv=732-26-
3&system-type=BB&p=l
2,4,6-tris(tert-
butyl)phenol
VQ
95%
http://enovationchem.com/productDetails.asp?cellC=+bgcolor
%3D%27%23E8F8FF%27+&productlD=K73850
2,4,6-tris(tert-
butyl)phenol
VQ
98%
http://www.finetechnology-
ind.com/product/AII%20product%20List/732-26-3.html
2,4,6-tris(tert-
butyl)phenol
5 to 500 grams
95%
http://fluorochem.co.uk/Products/Search?searchTvpe=C&sear
chText=732-26-3
2,4,6-tris(tert-
butyl)phenol
VQ
99+%
https://georganics.sk/products/speci/2A6-Tri-tert-
butvlphenol.php
2,4,6-tris(tert-
butyl)phenol
NL
NL
http://www.chinadavangchem.com/product/18448-it.html

2,4,6-tris(tert-
butyl)phenol
VQ
98%
http://www.ialor-chem.com/ildetailpro.php?id=102297
2,4,6-tris(tert-
butyl)phenol
VQ
Distributor of
Adamas, Bide,
Meryer, and
TCI America
http://www.bidepharmatech.com/en/product/detail/BD66408
.html
2,4,6-tris(tert-
butyl)phenol
25 grams
99.5%
https://lgcstandards.com/HK/en/2-4-6-Tri-tert-
butvlphenol/p/DRE-C17667700
2,4,6-tris(tert-
butyl)phenol
250 grams
UP
https://orderbb.emolecules.com/search/#?auerv=732-26-
3&svstem-tvpe=BB&p=l
2,4,6-tris(tert-
butyl)phenol
100 grams
95%
http://www.matricscientific.com/099057.html
2,4,6-tris(tert-
butyl)phenol
1 to 10
milligrams
90%
https://mcule.com/MCULE-7929720338
2,4,6-tris(tert-
butyl)phenol
25 to 500 grams
98%
http://www.bidepharmatech.com/en/product/detail/BD66408
.html
2,4,6-tris(tert-
butyl)phenol
100 grams
95+%
https://mcule.com/MCULE-7929720338
2,4,6-tris(tert-
butyl)phenol
100 grams
95+%
https://www.molport.com/shop/moleculelink/2-4-6-tri-tert-
butvlphenol/519180
2,4,6-tris(tert-
butyl)phenol
100 grams
UP
https://orderbb.emolecules.com/search/#?auerv=732-26-
3&svstem-tvpe=BB&p=l
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.oxchem.com/ox/Product/pro item.aspx?num=AX
8066408
2,4,6-tris(tert-
butyl)phenol
50 grams (VQ)
UP
https://www.pfaltzandbauer.com/Search.aspx

Page 9 of 18

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Given Name
Available
Quantities
Purity (%)
Reference
2,4,6-tris(tert-
butyl)phenol
1 to 3 grams
>90%
https://www.molport.com/shop/moleculelink/2-4-6-tri-tert-
butylphenol/519180
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.rosewachem.com/732-26-3.html
2,4,6-tris(tert-
butyl)phenol
VQ
UP
https://www. rvansci.com/Droducts/7645732/view
2,4,6-tris(tert-
butyl)phenol
100 grams
UP
https://www.scbt.com/scbt/product/2-4-6-tri-tert-
butvlphenol-732-26-3
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.etradeasia.com/products detail/0/1011138/4133
/2 4 6 tri tert butvlphenol CAS 732 26 3 Pharmaceutical



lntermediate.html
2,4,6-tris(tert-
butyl)phenol
9071.85
kilograms (10
tons)
99%
http://www.ichemical.com/chemicals/cas-732-26-3
2,4,6-tris(tert-
butyl)phenol
NL
>99%
http://www.chinaseniorsupplier.com/Environment/Catalvsts
Chemical Auxiliary Agents/401209807/ANTIOXIDANT SONOX



246.html
2,4,6-tris(tert-
butyl)phenol
100 grams
95%
http://sigmaaldrich.com/catalog/search?interface=CAS+No.&t
erm=732-26-
3&N=0&mode=partialmax&focus=product&lang=en®ion=U



S
2,4,6-tris(tert-
butyl)phenol
25 grams
98%
https://www.spectrumchemical.com/OA HTML/chemical-
products 246-Tri-tert-butvlphenol TCI-
T0359.isp?minisite=10020&respid=22372
2,4,6-tris(tert-
butyl)phenol
10 to 100
milligrams
UP
https://www.molport.com/shop/moleculelink/2-4-6-tri-tert-
butylphenol/519180
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.svntree. com/index. php?route=product/search=73


2-26-3
2,4,6-tris(tert-
butyl)phenol
NL
NL
https://toxnet.nlm.nih.gov/cgi-
bin/sis/search2/r?dbs+hsdb:(a)term+(ฎrn+(ฎrel+732-26-3
2,4,6-tris(tert-
butyl)phenol
25 grams
98%
http://tcichemicals.com/eshop/en/us/commoditv/T0359/
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.thsci.com/732-26-3.html
2,4,6-tris(tert-
butyl)phenol
VQ
UP
http://www.wonder-chem.com/product/310061.html
VQ-varied quantities
UP - unknown purity
NL- not listed information
Vendors also offer commercial/retail products that are mixtures of several chemicals, including 2,4,6-
TTBP. Table 3 below shows products containing 2,4,6-TTBP at various concentrations and in proprietary
blends available for general consumer purchase online. This list is provided for informational purposes
only. EPA and its employees do not endorse any of the products or companies.
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Table 3. List of Products Available in Commerce
Product
Description and Price
Reference
Arctic Cat, Inc.
Arctic Cat Fuel Injector Cleaner
Fuel additive, conditioner, and
stabilizer
12 ounces - $8.99
http://arcticcatlubricants.com/wp-
content/uploads/2014/04/10144-Arctic-Cat-
Fuel-lniector-Cleaner-07092015.pdf
BG
BG CF5 Fuel System Treatment
Fuel system treatment
11 ounces - $14.78
https://www.amazon.com/BG%ADCF5%ADFuel
%ADSystem%ADTreatment/dp/B005GDZPCY
Champion Brands, LLC
CHAMPION ฎ Fuel Stabilizer
Fuel additive and stabilizer
8 ounces-$5.23
96 ounces - $62.76
http://championbrands.com/MSDS/4205M-
Champion%20Fuel%20Stabilizer%20MSDS.pdf
Cyclo Industries, Inc.
C-290/292 Fuel Stabilizer
Fuel additive and stabilizer
96 ounces - $58.56
http://cvclo.com/wp-
content/uploads/2015/12/C290-
C292 SDS Mav2014.pdf
Eurol Lubricants
Briggs and Stratton Fuel Fit
Fuel additive, conditioner, and
stabilizer
8 ounces-$16.84
http://www.centralspares.co.uk/files/downloa
ds/BS992380%20Briggs%20and%20Stratton%2
0fuel%20fit.pdf
Fuelcare, LTD
Octamar LI-5 Plus
Fuel preservative
34 ounces - $24.37
https://www.fuelcare.eom/pdf/octamarmsds.p
df
Gold Eagle -
WERCS Sta-Bil Fuel Stabilizer
Fuel additive and stabilizer
8 ounces-$15.00
10 ounces - $12.00
32 ounces - $21.00
40 ounces - $20.00
128 ounces - $75.00
1 gallon - $63.00
http://www.homedepot.com/catalog/pdflmag
es/a6/a6e7aabl-al83-46c9-a3c6-
f590e516a377.pdf
Rislone
Rislone ฎ Fuel Injector Cleaner with
Upper Cylinder Lubricant
Fuel additive, conditioner, and
stabilizer
6 ounces - $3.18
72 ounces - $48.00
https://www.whatsinproducts.com/files/brand
s pdf/1396211702.pdf
SKF Maintenance Products
LGEM 2
Bearing lubricant
14 ounces - $27.36
http://www.skf.com/us/products/lubrication-
solutions/lubricants/safetv-data-
sheets/index.html
5. Uses
Industrial Uses
As noted above, for the 2016 CDR period, data reported to EPA indicate that this chemical is processed
as a reactant or intermediate in the basic organic chemical manufacturing sector. Additionally, both
commercial and consumer uses were reported in the category fuels and related products.
Industry has reported to EPA that 2,4,6-TTBP has historically been used as a reactant, an intermediate,
a product in organic chemical manufacturing, and as an antioxidant in plastic and resin manufacturing.
Commercial and Consumer Uses
As noted previously, for the 2016 CDR period, both commercial and consumer uses were reported to
EPA in the category fuels and related products.
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2,4,6-TTBP has been noted as an ingredient in automobile fuel injector cleaners, as well as in lubricant
additives and fuel additives (as an antioxidant) in gasoline and jet fuel11.
As indicated in Table 1 and Table 3, some of these fuel additive products are available to consumers for
automotive, marine or miscellaneous small engine uses.
Potential Other Uses
In 2008, Environment Canada reported in its Screening Assessment of 2,4,6-TTBP that the substance
had historically been used as a lubricant additive and it was currently used in Canada as a fuel, oil, and
gasoline additive. It was also reported that several additional use pattern codes and corresponding
applications were noted in 2001 and 2007 surveys, including: feedstock fuels, chemical intermediates,
pesticides, fertilizers, salt for deicing, solvents, cutting fluids, aerosol propellants, hydraulic fluids,
lubricants and additives, cleaning/washing agents and additives, plant protection products, agricultural
products, explosives, antioxidants, corrosion inhibitors, tarnish inhibitors, scavengers, and anti-scaling
agents12,13.
According to the Convention for the protection of the Marine Environment (OSPARCommission) in
2006, possible applications of 2,4,6-TTBP in Denmark, Norway and Sweden include a chemical
intermediate in the production of antioxidants used in rubber and plastic, a lubricating agent in the
transportation sector, a by-product in the production of 4-tert-butylphenol, as an additive for gasoline
and fuel oil distillate, and in the offshore sector14.
From 1998 to 2014 the Swedish Chemicals Agency flow analysis for chemical substances listed 2,4,6-
TTBP in a category of 52 "butylphenols" used in 2763 products; 440 of which are consumer specific
products15.
According to the Substances in Preparation in Nordic Countries (SPIN) database, 2,4,6-TTBP has been
reportedly used in industrial use (NACE) classifications between 2001 and 2014 for:
•	Wholesale and retail trade and repair of motor vehicles (NACE Code G45),
•	Manufacture of machinery and equipment (NACE Code C28),
11	DeLima Associates. Consumer Product Information Database.
https://www.whatsinproducts.eom/chemicals/view/l/4995/000732-26-3/Polvolefin%20alkvl (accessed December 16,
2016) and U.S. National Institutes of Health ToxNet Toxicology Data Network, http://toxnet.nlm.nih.gov (accessed
December 20, 2016)
12	Environment Canada & Health Canada, Screening Assessment for the Challenge - Phenol, 2,4,6-tris(l,l-dimethylethyl)-
(2,4,6-tri-tert-butylphenol). November 2008, https://www.ec.gc.ca/ese-ees/92E21475-4289-446B-BCDA-
E3E71BB93EF2/batch2 732-26-3 en.pdf
13	November 17, 2001. Canadian Environmental Protection Act, 1999 - Notice with Respect to Certain Substances on the
Domestic Substances List. Canada Gazette: Part I. 135:46; 4194.
14	Convention for the Protection of the Marine Environment of the North Atlantic (OSPAR), 2,4,6-tri-tert-butylphenol,
(OSPAR Commission, 2006 update) 274/2006, http://www.ospar.org/documents?v=6977
15	Swedish Chemicals Agency (KEMI). Flow analysis for chemical substances - butyl phenols.
(http://webapps.kemi.se/flodesanalvser/FlodesanalvserSchema.aspx?SchemalD=1401; accessed December 16, 2016)
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•	Sale, maintenance and repair of motor vehicles and motorcycles; retail sale of automotive fuel
(NACE Code 50),
•	Construction (NACE Code 45),
•	Manufacture of machinery and equipment (NACE Code 29), and
•	Manufacture of coke, refined petroleum products, and nuclear fuel (NACE Code 23)16
According to a 2010 study of products in Norway, 2,4,6-TTBP was used in these applications:
•	Additive in fuel, oil, gasoline, and lubricants,
•	Phenolic resins (rubber/ink),
•	Chemical intermediate (starting material for synthesis of 2,6-di-tert-butyl-4-methoxylphenol -
antioxidant), and
•	Additive to plastics (polymeric construction compounds used for flooring, pavement, sports
grounds, drainage pipes, stabilizer for diene rubber, vulcanized rubber)17
Although importation, manufacture, and use of 732-36-3 is banned in Japan, the Japanese based
National Institute of Technology and Evaluation found that 2,4,6-TTBP has been used as an antioxidant
and additive (limited to those for lubricating and fuel oils) and in lubricating oils18,19.
The Australian Government Department of Health conducted a recent assessment under the National
Industrial Chemicals Notification and Assessment Scheme that concluded the chemical may be used in
Australia as an additive for hydrocarbon fuels and a component of industrial lubricants20.
One vendor listed in Table 1 (Shandong Kanghong International Trade Company Limited) markets
2,4,6-TTBP as potentially being used for:
•	antioxidant in rubber, plastics, and oil
•	use in latex manufacture (borealis group)
•	heat stabilizer for polyethylene, polypropylene, and high impact polystyrene21
16Substances in Preparations in Nordic Countries, http://www.spin2000.net/spinmyphp/7pich732263 (accessed December
12, 2016)
"Lambert, N., Rostock, C., Bonden, A. (2010). Dodecyl- and tri-tert-butylphenol in Products in Norway. Climate and
Pollution Agency, http://www.miliodirektoratet.no/old/klif/publikasioner/2744/ta2744.pdf
18Government of Japan. 2007. Evaluation of Chemical Substances and Regulations of their Manufacture, etc. Cabinet Order
No. 322 of 2007
"Environment Canada & Health Canada, Screening Assessment for the Challenge - Phenol, 2,4,6-tris(l,l-dimethylethyl)-
(2,4,6-tri-tert-butylphenol). November 2008, https://www.ec.gc.ca/ese-ees/92E21475-4289-446B-BCDA-
E3E71BB93EF2/batch2 732-26-3 en.pdf
20Australian Government Department of Health. 2016. National Industrial Chemicals Notification and Assessment Scheme
Environmental Tier II Assessment for Phenol, 2,4,6-tris(l,l-dimethylethyl), https://www.nicnas.gov.au/chemical-
information/imap-assessments/imap-assessments/tier-ii-environment-assessments/2-4-6-tri-tert-butvlphenol
21eTrade Asia website. Shandong Kanghong International Trade Company Limited order for 732-26-3.
(http://www.etradeasia.com/products detail/0/1011138/4133/2 4 6 tri tert butvlphenol CAS 732 26 3 Pharmaceutic
al lntermediate.html: accessed December 19, 2016)
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Another vendor (Shanghai Yancui Import and Export Co., Ltd.) markets 2,4,6-TTBP (known as
Antioxidant Sonox 246 or Antioxidant 744) as suitable for use in natural and synthetic rubbers, glues,
polyolefins plastics, and the main raw material of efficient phosphite antioxidants22.
6. Disposal of Waste and Recycling/Recovery
2,4,6-TTBP is not listed as a hazardous waste under the Resource Conservation and Recovery Act
(RCRA).
USEFUL TYPES OF INFORMATION
This document presents a summary of information currently available to EPA on this chemical. EPA is
interested in obtaining information to more fully characterize the manufacturing, processing,
distribution, disposal, and use of this chemical, to inform the development of the exposure and use
assessment for this chemical, and to inform any subsequent risk management efforts. For example,
EPA is interested in obtaining information on:
•	the functional uses for this chemical;
•	what types of products contain this chemical;
•	which industry sectors use this chemical;
•	what volume of the chemical is used;
•	which uses have been discontinued or phased out;
•	exposure scenarios for this chemical; and
•	in which articles this chemical is found.
22Shanghai Yancui Import and Export Co., Ltd. Product details.
(http://www.chinaseniorsupplier.com/Environment/Catalvsts Chemical Auxiliary Agents/401209807/ANTIQXIDANT SON
OX 246.html: accessed December 12, 2016)
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APPENDIX: SOURCES CONSULTED
•	U.S. EPA Chemical Inventory
https://www.epa.gov/tsca-inventory
•	U.S. EPA ChemView
https://iava.epa.gov/chemview
•	TRI P2 information
https://www.epa.gov/toxics-release-inventorv-tri-program/pollution-prevention-p2-and-tri
•	U.S. EPA HPV HC (access through Chemical Data Access Tool - CDAT)
https://java.epa.gov/oppt chemical search/
•	U.S. EPA HPVIS and HPV HC (access through Chemical Data Access Tool - CDAT)
https://java.epa.gov/oppt chemical search/
•	DfE Alternatives Assessments
https://www.epa.gov/saferchoice/design-environment-alternatives-assessments
•	Safer Chemical Ingredients List
https://www.epa.gov/saferchoice/safer-ingredients
•	Green Chemistry awards
https://www.epa.gov/greenchemistry/presidential-green-chemistry-challenge-winners
•	Greener products and services
https://www.epa.gov/greenerproducts/identify-greener-products-and-services
•	Pollution Prevention
https://www.epa.gov/p2/pollution-prevention-case-studies
https://www.epa.gOv/p2/grant-programs-pollution-prevention#sra
https://www.epa.gov/p2/pollution-prevention-tools-and-calculators
•	U.S. EPA InertFinder
https://iaspub.epa .gov/apex/pesticides/f?p=101:l:
•	U.S. EPA Pesticide Chemical Search
https://iaspub.epa .gov/apex/pesticides/f?p=CH EM ICALSEARCH:1:0::NQ:1::
•	U.S. EPA Endocrine Disruptor Screening Progmrn
https://www.epa.gov/ingredients-used-pesticide-products/endocrine-disruptor-screening-
program-tier-l-assessments
•	U.S. EPA Hgzgrdous Wgste
https://www.epa.gOv/hw/learn-basics-hazardous-waste#regulations
•	U.S. EPA Superfund chemicgl dgtg mgtrix
https://www.epa.gov/superfund/superfund-chemical-data-matrix-scdm-query
•	U.S. EPA Hgzgrdous Air Pollutgnts
https://www.epa.gov/haps/initial-list-hazardous-air-pollutants-modifications
•	U.S. EPA Significgnt New Alterngtives Policy (SNAP)
https://www.epa.gov/snap
•	U.S. EPA Volgtile Orggnic Compounds
https://www.epa.gov/indoor-air-qualitv-iaq/technical-overview-volatile-organic-
compounds#definition
•	U.S. EPA Toxic gnd priority pollutgnts under the Clegn Wgter Act
https://www.epa.gOv/eg/toxic-and-priority-pollutants-under-clean-water-act#toxic
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•	U.S. EPA Contaminant Candidate list under the Safe Drinking Water Act
https://www.epa.gOv/ccl/contaminant-candidate-list-3-ccl-3#chemical-list
•	U.S. EPA IRIS Assessment
https://cfpub.epa.gov/ncea/iris2/atoz.cfm
•	U.S. EPASffS
https://iaspub.epa.gov/sor internet/registry/substreg/searchandretrieve/substancesearch/search.
do
•	U.S. EPA Chemical and Product Categories (CPCat) Database
https://actor.epa.gov/cpcat/faces/home.xhtml
•	U.S. National Library of Medicine ChemlDplus
https://chem.sis.nlm.nih.gov/chemidplus/
•	U.S. National Library of Medicine Hazardous Substance Data Bank (HSBD)
https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
•	U.S. Department of Health & Human Services Household Products Database
https://hpd.nlm.nih.gov/index.htm
•	OSHA Chemical Hazards and Toxic Substances
https://www.osha.gov/SLTC/hazardoustoxicsubstances/index.html
•	NIOSH Workplace Safety and Health Topics Chemicals
http://www.cdc.gov/niosh/topics/chemical.html
•	NIOSH Pocket Guide to Chemical Hazards
http://www.cdc.gov/niosh/npg/npgdcas.html
•	CPSC Chemicals
http://www.cpsc.gov/en/Research--Statistics/Chemicals/
•	CPSC FHSA
https://www.cpsc.gov/Business--Manufacturing/Business-Education/Business-Guidance/FHSA-
Requirements/
•	Food and Drug Administration List of Databases
http://www.fda.gov/Forlndustrv/FDABasicsforlndustry/ucm234631.htm
•	NTP (National Toxicology Program) Substances studied by NTP
http://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status
•	Department of Energy Protective Action Criteria Database
http://energy.gov/ehss/protective-action-criteria-pac-aegls-erpgs-teels-rev-29-chemicals-concern-
may-2016
•	California Department of Toxic Substances Control Toxics in Products
http://www.dtsc.ca.gov/PollutionPrevention/ToxicslnProducts/index.cfm
http://www.dtsc.ca.gov/SCP/CandidateChemicalsList.cfm
http://www.dtsc.ca.gov/SCP/WhatlsAPriorityProduct.cfm
•	California Office of Environmental Health Hazard Assessment Proposition 65
http://oehha.ca.gov/proposition-65/chemicals
http://oehha.ca.gov/proposition-65/proposition-65-list
•	California Office of Environmental Health Hazard Assessment Biomonitoring
http://biomonitoring.ca.gov/chemicals
•	California permissible exposure limits for chemical contaminants
https://www.dir.ca.gov/title8/5155table acl.html
•	California hazardous substance list
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https://www.dir.ca.gov/title8/339.html
•	California Safe Cosmetics Program - list of chemical agents known or suspected to cause cancer or
developmental or other reproductive harm.
http://www.cdph.ca.gov/programs/cosmetics/Pages/default.aspx
https://safecosmetics.cdph.ca.gov/search/Default.aspx
•	Maine chemicals of high concern
http://www.maine.gov/dep/safechem/highconcern/
•	Massachusetts Toxics Use Reduction Act (TURA) (link includes a link to Higher hazard substances
list)
http://www.mass.aov/eea/waste-mant-recyclina/toxics/toxic-use-reduction/toxics-use-reduction-
act/
•	Massachusetts Complete list of TURA chemicals
http://www.mass.gov/eea/agencies/massdep/toxics/tur/toxics-use-reduction-act-tura-reporting-
and-fees.html
•	Lowell Center for Sustainable Production Chemical, Policy and Science Initiative
http://www.chemicalspolicv.org/chemicalspolicy.us.state.database.php
•	Minnesota Department of Health Toxic Free Kids Act Chemicals of High Concern
http://www.health.state.mn.us/divs/eh/hazardous/topics/toxfreekids/highconcern.html
•	Michigan Environmental Health Topics
http://www.michigan.gOv/mdhhs/0.5885.7-339-71548 54783 54784 74881-13050~.00.html
•	New Hampshire Regulated Toxic Air Pollutants
http://des.nh.gov/organization/commissioner/legal/rules/documents/env-al400.pdf
•	New Jersey Right to Know Hazardous Substances
http://web.doh.state.nj.us/rtkhsfs/rtkhsl.aspx
•	Oregon Priority Persistent Pollutants (in water)
http://www.deq.state.or.us/wq/SB737/
•	Oregon Pollutant Profiles
http://www.deq.state.or.us/wq/SB737/docs/LegRpAtt420100601.pdf
•	Oregon Reducing Toxics in Oregon
http://www.oregon.gov/deq/Pages/ToxicsReduction.aspx
•	Oregon Chemicals of Concern for Children's Health
http://public.health.oregon.gov/HealthvEnvironments/HealthyNeighborhoods/ToxicSubstances/Pa
ges/childrens-chemicals-of-concern.aspx
•	Pennsylvania Department of Labor and Industry Hazardous Substance List
http://www.pacode.com/secure/data/034/chapter323/chap323toc.html
•	Rhode Island Air Resources - Air Toxics
http://www.dem.ri.gov/pubs/regs/regs/air/air22 08.pdf
•	Vermont Chemical Disclosure Program for Children's Products
http://www.healthvermont.gov/enviro/chemical/cdp.aspx
•	Washington Chemicals of High Concern to Children
http://www.ecy.wa.gov/programs/hwtr/rtt/cspa/chcc.html
•	Washington Children's Safe Products Act
http://apps.leg.wa.gov/RCW/default.aspx?cite=70.240
•	Washington Department of Labor & Industries SHARP Publications
http://www.lni.wa.gov/Safety/Research/Pubs/default.asp
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•	National Conference of State Legislatures
http://www.ncsl.org/research/environment-and-natural-resources/state-chemical-statutes.aspx
•	Canada Chemicals Portal
http://chemicalsubstanceschimiques.gc.ca/index-eng.php
•	EU ECHA website
https://echa.europa.eu/
•	Australia NICNAS Chemical Information
https://www.nicnas.gov.au/chemical-information
•	Japan Chemical Risk Information Platform (CHIRP)
http://www.nite.go.jp/en/chem/chrip/chrip search/systemTop
•	OECD eChemPortal
http://www.echemportal.org/echemportal/index?pagelD=Q&request locale=en
•	Royal Society of Chemistry ChemSpider http://www.chemspider.com/
•	Stockholm Convention on Persistent Organic Pollutants
http://chm.pops.int/TheConvention/ThePOPs/ListingofPOPs/tabid/25Q9/Default.aspx
http://chm.pops.int/TheConvention/ThePOPs/ChemicalsProposedforListing/tabid/251Q/Default.as
ฃX
•	WHO IPCS (UN)
http://www.who.int/ipcs/en/
•	Other-worker protection information
http://www.dguv.de/ifa/gestis/gestis-internationale-grenzwerte-fuer-chemische-substanzen-limit-
values-for-chemical-agents/index-2.jsp
•	DeLima Associates Consumer Product Information Database (CPID)
https://www.whatsinproducts.eom/chemicals/index/l
•	SRC FatePointers Search Module PHYSPROP
http://esc.syrres.com/fatepointer/search.asp
•	Product and company websites
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