August 2017 Office of Chemical Safety and Pollution Prevention U.S. EPA Preliminary Information on Manufacturing, Processing, Distribution, Use and Disposal: 2f4f6-Tris(tert-butyl)phenol CASRN: 732-26-3 August 2017 Support document For Docket EPA-HQ-OPPT-2016-0734 Page 1 of 18 ------- This document provides a preliminary public summary of available information collected by EPA's Office of Pollution Prevention and Toxics (OPPT) in the Office of Chemical Safety and Pollution Prevention (OCSPP) on the manufacturing (including importing), processing, distribution in commerce, use, and disposal of this chemical. This is based on existing data available to EPA, including information collected under the Chemical Data Reporting rule, Toxics Release Inventory (if available), information from other Agency databases, other U.S. Government agencies, publicly available information from states, and a review of published literature. In addition, the document includes information reported to EPA by producers and users of the chemical in the United States and in other countries. This preliminary use information and any additional use information received in the docket by December 9, 2017, will inform efforts to identify, under section 6(h)(1)(B) of the Toxic Substances Control Act (TSCA), whether exposure to this chemical is likely, under the conditions of use, either to the environment, the general population, or to a potentially exposed or susceptible subpopulation identified by EPA. The information will also inform any risk management efforts following the exposure and use assessment under TSCA section 6(h)(1)(B). Mention of trade names in this document does not constitute endorsement by EPA. To verify products or articles containing this chemical currently in commerce, EPA has identified several examples. Any lists are provided for informational purposes only. EPA and its employees do not endorse any of the products or companies. This document does not contain confidential business information (CBI). Page 2 of 18 ------- TABLE OF CONTENTS CONTACT 3 MANUFACTURING, PROCESSING, DISTRIBUTION, USE, AND DISPOSAL 4 1. Manufacturing (Including Importing) 4 2. Processing 5 3. Products and Articles 5 4. Distribution (Includes Retailers) 7 5. Uses 11 6. Disposal of Waste and Recycling/Recovery 14 USEFUL TYPES OF INFORMATION 14 APPENDIX: SOURCES CONSULTED 15 CONTACT Todd Coleman, National Program Chemicals Division, Office of Pollution Prevention and Toxics. 202- 564-1208, Coleman.Todd@epa.gov Peter Gimlin, National Program Chemicals Division, Office of Pollution Prevention and Toxics. 202-566- 0515, Gimlin.Peter@epa.gov Docket: EPA-HQ-OPPT-2016-0734 Page 3 of 18 ------- MANUFACTURING, PROCESSING, DISTRIBUTION, USE, AND DISPOSAL 1. Manufacturing (Including Importing) For the 2016 Chemical Data Reporting (CDR) period, data reported indicate that there is one company manufacturing or importing 2,4,6-TTBP in the United States 1,2. The volume of 2,4,6-TTBP manufactured was claimed as confidential business information (CBI). There is no Toxics Release Inventory (TRI) data available for this chemical as it is not required to be reported under TRI. PubChem reported that in 2006, 2,4,6-TTBP was produced in a production range between 10 and less than 50 million pounds3. According to the EPA's 2009 Screening-Level Hazard Characterization - Alkylphenols Category 2,4,6- TTBP had an aggregate production and/or import volume in the U.S. of between 10 million and 50 million pounds4. Manufacturing Process 2,4,6-TTBP has been listed as an impurity in 2,6-di-tert-butylphenol and may be a byproduct in the manufacture of 4-tert-butylphenol5. 2,4,6-TTBP can also be obtained from 2,4-di-tert-butylphenol; 4-tert-butylphenol; and 2-tert- butylphenol at different proportions given specific reaction conditions. 3-tert-butylphenol can also be obtained from mixtures containing 2,4,6-TTBP and other phenols6. Manufacturers (including importers) are required to report under CDR if they meet certain production volume thresholds, generally 25,000 lb or more of a chemical substance at any single site. Reporting is triggered if the annual reporting threshold is met during any of the calendar years since the last principal reporting year. In general, the reporting threshold remains 25,000 lb per site. However, a reduced reporting threshold (2,500 lb) now applies to chemical substances subject to certain TSCA actions, https://www.epa.gov/chemical-data-reporting/how-report-under-chemical-data-reporting 2 Manufacture means to manufacture, produce, or import for commercial purposes. Manufacture includes the extraction, for commercial purposes, of a component chemical substance from a previously existing chemical substance or complex combination of chemical substances. (40 CFR 711.3) epa.gov/sites/production/files/2015-12/documents/cdr fact sheet importers final dec2015 O.pdf2 3 National Institutes of Health, PubChem Database, https://pubchem.ncbi.nlm.nih.gOv/compound/2 4 6-Tri-tert- butvlphenol#section=Top (accessed December 20, 2016) 4 U.S. EPA. 2009. Screening-Level Hazard Characterization (Alkylphenols Category), http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.175.5613&rep=repl&type=pdf 5 Convention for the Protection of the Marine Environment of the North Atlantic (OSPAR), 2,4,6-tri-tert-butylphenol, (OSPAR Commission, 2006 update) 274/2006, http://www.ospar.org/documents?v=6977 6 Fiege, H., Voges, H. W., Hamamoto, T., et al. 2000. Phenol Derivatives. Ullmanns Encyclopedia of Industrial Chemistry. Page 4 of 18 ------- 2. Processing For the 2016 CDR period, data reported indicate that this chemical is processed7 for thefollowing: As a reactant or intermediate in the following sectors: o Basic organic chemical manufacturing Both commercial and consumer uses were reported in the category: o Fuels and related products. 2,4,6-TTBP has been noted by the National Library of Medicine in ToxNet as the starting material for the synthesis of 2,6-di-tert-butyl-4-methoxyphenol, which is noted as a powerful antioxidant8. 3. Products and Articles A 1995 U.S. Patent Number 5,399,275 by the Lubrizol Corporation notes the use of 2,4,6-TTBP at a concentration of 15% under the category: "environmentally friendly viscosity index improving compositions". Lubrizol Corporation was noted as a holder of patents that use the Isonox 133 chemical at different concentrations in their manufactured products9. 2,4,6-TTBP is mentioned in 1,829 additional patents according to NIH's PubChem10. EPA identified the following types of products based on a search of available sources for products containing 2,4,6-TTBP. EPA and its employees do not endorse any of the products or companies. Table 1. List of Products Trade Name Use of product % by weight of chemical Link to references, SDS or industry information Ethanox 4760E Automotive 5.5% http://www.sfm.state.or.us/CR2K SubDB/MS DS/ETHANOX 4760 E.PDF Arctic Cat Fuel Injector Cleaner Automotive <0.1% http://arcticcatlubricants.com/wp- content/uploads/2014/04/10144-Arctic-Cat- Fuel-lnjector-Cleaner-07092015.pdf Tolad 3915 Automotive; Industrial 10-30% http://hazard.com/msds/f2/clc/clcxv.html 7 The term "process" means the preparation of a chemical substance or mixture, after is manufacture, for distribution in commerce in the same form or physical state as, or in a different form or physical state from, that in which it was received by the person so preparing such substance or mixture, or as part of an article containing the chemical substance or mixture. http://uscode.house.gov/view. xhtml?path=/prelim(5)titlel5/chapter53&edition=prelim 8 U.S. National Institutes of Health ToxNet Toxicology Data Network, https://toxnet.nlm.nih.gov/cgi- bin/sis/search2/r?dbs+hsdb:(5)term+(5)rn+(5)rel+732-26-3 (accessed December 20, 2016) 9 Lange, R. M., Seebauer, J. G., and Mamajek, C. A. (1995). Environmentally Friendly Viscosity Index Improving Compositions. U.S. Patent 5,399,275, filed Dec. 10,1993 and issued Mar. 21,1995, https://www.google.com/patents/US53992757chen 10 National Institutes of Health, PubChem Database - Patents, https://pubchem.ncbi.nlm.nih.gov/compound/12902#section=Patents (accessed December 20, 2016) Page 5 of 18 ------- Trade Name Use of product % by weight of chemical Link to references, SDS or industry information BG CF5 Fuel Supplement Automotive 0.1-1% https://www.amazon.com/BG%ADCF5%ADFu el%ADSystem%ADTreatment/dp/B005GDZPCY Regular Unleaded Petrol Automotive *concentration s above the limit of detection http://caltex.co.nz/resources/msds/ Casite Injector Sting/Complete Fuel System Cleaner Automotive <1% http://mvmotorhonev.com/wp- content/uploads/2016/04/C175-12 C177- 12 Casite-lniector-Sting-Complete-Fuel- System-Cleaner.pdf CHAMPION ฎ Fuel Stabilizer Automotive 0-3% http://championbrands.com/MSDS/4205M- Champion%20Fuel%20Stabilizer%20MSDS.pdf CHAMPION ฎ Engine Oil Additive Automotive <1% http://www.championbrands.com/MSDS/BT- engine-protect.pdf Max 44E Automotive <0.1% http://msdsdigital.com/max-44e-msds Fuel Stabilizer Automotive <0.018% http://cvclo.com/wp- content/uploads/2015/12/C290- C292 SDS Mav2014.pdf Marine Fuel Stabilizer Automotive; Marine 0.02% http://msds.rowleys.com/cm5210.pdf lonol BF 200 Antioxidant <20% http://www.ingurumena.eiev.euskadi.eus/r49 564/es/contenidos/informacion/planta biodi esel Puerto bilbao/es 13530/adiuntos/1005 9-AAI-AnexoA-GV-Nov2005.pdf 1170 Power Stroker Automotive <0.5% http://wcs.mi.safeschoolssds.com/document/ repo/5855ad74-748f-lldf-9b6e- d8d230712f36 Eurol SR 2000 Road Racing Automotive 0s- 1 1 1 o http://www.eurol.com/en/productfiles/85914 -en el28906 eurol-sr-2000-road- racing sds eurol 11.html Briggs and Stratton Fuel Fit Automotive; Industrial Not reported http://www.centralspares.co.uk/files/downlo ads/BS992380%20Briggs%20and%20Stratton %20fuel%20fit.pdf Octamar LI-5 Plus Automotive 0.09-0.99% https://www.fuelcare.com/pdf/octamarmsds. pdf WERCS Sta-Bil Fuel Stabilizer Automotive; Marine 3% (Isonox 133 mixture) http://www.homedepot.com/catalog/pdflma ges/a6/a6e7aabl-al83-46c9-a3c6- f590e516a377.pdf Duradฎ AX22 Liquid Phenolic Antioxidant Automotive; Industrial Not reported http://lpa.com.mx/pdf/Durad%20AX22.pdf McCullock Fuel Stabiliser Automotive; Industrial >0.25 - <1% http://www.mcculloch.com/ddoc/MCCE/MCC E2015 AAen/MCCE2015 AAen McCulloch%2 0Fuel%20Stabiliser .pdf Total Fuel System Cleaner Automotive <1% http://www.hvperlube.com/c3/total-fuel- system-cleaner-c9.html STOK9 Automotive <1% http://www.champ- energie.fr/sites/default/files/fds stok9 vs3.1 fr.pdf Page 6 of 18 ------- Trade Name Use of product % by weight of chemical Link to references, SDS or industry information Mile Hi Automotive Not Reported http://www.conncoll.edu/media/website- media/offices/ehs/envhealthdocs/Mile-Hi.pdf http://www. certifiedlabs.com/certified/Drodu ctView bvName.asp?countrv=USA&language= &language id=4&product cat=name&product cat desc=Products+Bv+Name&pName=MILE +HI+RTU Antioxidant No. 37 (AO-37) Automotive; Aviation 15% http://www.certifiedlabs.com/certified/produ ctView bvName.asp?countrv=USA&language= &language id=4&product cat=name&product cat desc=Products+Bv+Name&pName=MILE +HI+RTU Jet Fuel JET A-l Automotive; Aviation 0-0.0031% http://www.orlenlietuva.lt/EN/ForBusiness/Pr oducts/Documents/JET%20A- 1%20%20MSDS%20%202016%20%200RLEN% 20%20Lietuva%20 en.pdf Carburetor and fuel injector cleaner Automotive 0s- 1 1 1 o https://rislone.com/ca/wp- content/uploads/2015/04/34705-SDS.pdf Fuel Injector Cleaner Automotive <2.5% https://rislone.com/sv/wp- content/uploads/2016/03/51701-51732- English-SDS.pdf Rislone ฎ Fuel Injector Cleaner with Upper Cylinder Lubricant Automotive <3% https://www.whatsinproducts.com/files/bran ds pdf/1396211702.pdf Yinox 333 Coating Not reported http://www.seechem.com/catalogue m.pdf 6729 Concentrate for low sulfur fuel oil Automotive; Industrial 0s- 1 1 1 o http://images.raiffeisen.com/Raicom/sdb/444 /aral konzentrat schwefelarmes heizoel d.p df Isonox 133 Chemical Intermediate 20% mixture of 732-26-3 and 2- (1,1- dimethylethyl)p henol Schenectady Chemicals, Inc. Section 8(e) Coordinator (CAP Agreement). ISONOX 133 February 25,1992, Public Docket Number 8EHQ-0292-2314 LGEM 2 Lubricating Grease 0.1-1% http://www.skf.com/us/products/lubrication- solutions/lubricants/safetv-data- sheets/index.html TY26275 (Gasoline Storage Stabilizer) Automotive <5% http://www.greenpartstore.com/assets/imag es/bulletins/2011/tv26275 msds.pdf RAO-038 Analytical Standard NL http://siri.org/msds/fl/bvk/bvkag.html Diesel Fuel Stabiliser Automotive; Industrial 0.1-1% http://msdsdigital.com/svstem/files/DIESEL F UEL STABILISER English.pdf 4. Distribution (Includes Retailers) General internet searches for distributors of 2,4,6-TTBP in raw form yielded many vendors selling various quantities (i.e., between one milligram and 9071.85 kilograms) at different purities (i.e., between 90% and 99%). Note that these are defined as distributors due to their marketing of 2,4,6- TTBP for sale and distribution; however, many may also be the manufacturers of 2,4,6-TTBP. Table 2 Page 7 of 18 ------- below illustrates the identified distributors of 2,4,6-TTBP in raw form. This list is provided for informational purposes only. EPA and its employees do not endorse any of the products or companies. Table 2. List of Distributors Given Name Available Quantities Purity (%) Reference 2,4,6-tris(tert- butyl)phenol VQ 96% http://www.abcr.de/shop/en/2-4-6-Tri-tert-butvl-phenol- 96.html/ 2,4,6-tris(tert- butyl)phenol 5 to 500 grams UP https://orderbb.emolecules.com/search/#?querv=732-26- 3&system-type=BB&p=l 2,4,6-tris(tert- butyl)phenol 1 to 1,000 gram package 97% http://www.amadischem.com/en/198540.htm 2,4,6-tris(tert- butyl)phenol VQ 98% http://ahhchemical.com/search.shtml 2,4,6-tris(tert- butyl)phenol VQ 98% https://aksci.com/item detail.php?cat=P329 2,4,6-tris(tert- butyl)phenol VQ UP http://akoscompounds.de/catalogue/akossampleretrieval- s.php?IDNUMBERS=AKOS002268919&TERM-732-26- 3&CIDcount+l 2,4,6-tris(tert- butyl)phenol VQ UP http://www.ambitner.com/reference/2543595 2,4,6-tris(tert- butyl)phenol 1 to 100 grams 95% http://www.acccorporation.com/products/CHM0007865 2,4,6-tris(tert- butyl)phenol 25 to 500 grams UP https://chem-space.com/search/58582eb3-2a8cf8-al5015b- df81da0/CSC000068363.html?currencv=usd https://orderbb.emolecules.com/search/#?auerv=732-26- 3&system-type=BB&p=l 2,4,6-tris(tert- butyl)phenol VQ 97% http://aokchem.com/aokdetail.php7id-8866 2,4,6-tris(tert- butyl)phenol 100 grams 95% http://www.arkpharminc.com/product/detail/AK114270.html 2,4,6-tris(tert- butyl)phenol 25 to 100 grams 92 to 95% http://online.aurorafinechemicals.com/StrSearch-new.asp 2,4,6-tris(tert- butyl)phenol VQ UP http://www.bepharm.com/web/en/product/pro item.aspx?id =B66408 2,4,6-tris(tert- http://www.bidepharmatech.com/en/product/detail/BD66408 butyl)phenol 100 grams 95+/-% .html https://orderbb.emolecules.com/search/#?querv=732- 26-3&system-type=BB&p=l 2,4,6-tris(tert- butyl)phenol VQ UP https://www.biosvnth.com/products/organic-svnthesis/basic- intermediates/products/W-104462. html 2,4,6-tris(tert- butyl)phenol 25 to 500 grams UP https://chem-space.com/search/58582eb3-2a8cf8-al5015b- df81da0/CSC000068363.html?currencv=usd 2,4,6-tris(tert- butyl)phenol VQ UP http://www.chembopharma.com/product/65415.html 2,4,6-tris(tert- butyl)phenol VQ Distributor of Angene, Ark Pharm,and Biocore products https://chem-space.com/search/58582eb3-2a8cf8-al5015b- df81da0/CSC000068363.html?currencv=usd 2,4,6-tris(tert- butyl)phenol 5 to 1,000 grams 98% http://www.combi-blocks.com/cgi-bin/find.cgi7QB-5132 Page 8 of 18 ------- Given Name Available Quantities Purity (%) Reference 2,4,6-tris(tert- butyl)phenol VQ UP http://discofinechem.com/products/246-tri-tert-butvlphenol/ 2,4,6-tris(tert- butyl)phenol 25 to 500 grams UP http://product.b2star.com/192163.htm 2,4,6-tris(tert- butyl)phenol VQ Distributor of Acros, Angene, Ark, Bide, Combi-Blocks, Manchester Organics, Matrix Scientific, OxChem, TCI America https://orderbb.emolecules.com/search/#?querv=732-26- 3&system-type=BB&p=l 2,4,6-tris(tert- butyl)phenol VQ 95% http://enovationchem.com/productDetails.asp?cellC=+bgcolor %3D%27%23E8F8FF%27+&productlD=K73850 2,4,6-tris(tert- butyl)phenol VQ 98% http://www.finetechnology- ind.com/product/AII%20product%20List/732-26-3.html 2,4,6-tris(tert- butyl)phenol 5 to 500 grams 95% http://fluorochem.co.uk/Products/Search?searchTvpe=C&sear chText=732-26-3 2,4,6-tris(tert- butyl)phenol VQ 99+% https://georganics.sk/products/speci/2A6-Tri-tert- butvlphenol.php 2,4,6-tris(tert- butyl)phenol NL NL http://www.chinadavangchem.com/product/18448-it.html 2,4,6-tris(tert- butyl)phenol VQ 98% http://www.ialor-chem.com/ildetailpro.php?id=102297 2,4,6-tris(tert- butyl)phenol VQ Distributor of Adamas, Bide, Meryer, and TCI America http://www.bidepharmatech.com/en/product/detail/BD66408 .html 2,4,6-tris(tert- butyl)phenol 25 grams 99.5% https://lgcstandards.com/HK/en/2-4-6-Tri-tert- butvlphenol/p/DRE-C17667700 2,4,6-tris(tert- butyl)phenol 250 grams UP https://orderbb.emolecules.com/search/#?auerv=732-26- 3&svstem-tvpe=BB&p=l 2,4,6-tris(tert- butyl)phenol 100 grams 95% http://www.matricscientific.com/099057.html 2,4,6-tris(tert- butyl)phenol 1 to 10 milligrams 90% https://mcule.com/MCULE-7929720338 2,4,6-tris(tert- butyl)phenol 25 to 500 grams 98% http://www.bidepharmatech.com/en/product/detail/BD66408 .html 2,4,6-tris(tert- butyl)phenol 100 grams 95+% https://mcule.com/MCULE-7929720338 2,4,6-tris(tert- butyl)phenol 100 grams 95+% https://www.molport.com/shop/moleculelink/2-4-6-tri-tert- butvlphenol/519180 2,4,6-tris(tert- butyl)phenol 100 grams UP https://orderbb.emolecules.com/search/#?auerv=732-26- 3&svstem-tvpe=BB&p=l 2,4,6-tris(tert- butyl)phenol VQ UP http://www.oxchem.com/ox/Product/pro item.aspx?num=AX 8066408 2,4,6-tris(tert- butyl)phenol 50 grams (VQ) UP https://www.pfaltzandbauer.com/Search.aspx Page 9 of 18 ------- Given Name Available Quantities Purity (%) Reference 2,4,6-tris(tert- butyl)phenol 1 to 3 grams >90% https://www.molport.com/shop/moleculelink/2-4-6-tri-tert- butylphenol/519180 2,4,6-tris(tert- butyl)phenol VQ UP http://www.rosewachem.com/732-26-3.html 2,4,6-tris(tert- butyl)phenol VQ UP https://www. rvansci.com/Droducts/7645732/view 2,4,6-tris(tert- butyl)phenol 100 grams UP https://www.scbt.com/scbt/product/2-4-6-tri-tert- butvlphenol-732-26-3 2,4,6-tris(tert- butyl)phenol VQ UP http://www.etradeasia.com/products detail/0/1011138/4133 /2 4 6 tri tert butvlphenol CAS 732 26 3 Pharmaceutical lntermediate.html 2,4,6-tris(tert- butyl)phenol 9071.85 kilograms (10 tons) 99% http://www.ichemical.com/chemicals/cas-732-26-3 2,4,6-tris(tert- butyl)phenol NL >99% http://www.chinaseniorsupplier.com/Environment/Catalvsts Chemical Auxiliary Agents/401209807/ANTIOXIDANT SONOX 246.html 2,4,6-tris(tert- butyl)phenol 100 grams 95% http://sigmaaldrich.com/catalog/search?interface=CAS+No.&t erm=732-26- 3&N=0&mode=partialmax&focus=product&lang=en®ion=U S 2,4,6-tris(tert- butyl)phenol 25 grams 98% https://www.spectrumchemical.com/OA HTML/chemical- products 246-Tri-tert-butvlphenol TCI- T0359.isp?minisite=10020&respid=22372 2,4,6-tris(tert- butyl)phenol 10 to 100 milligrams UP https://www.molport.com/shop/moleculelink/2-4-6-tri-tert- butylphenol/519180 2,4,6-tris(tert- butyl)phenol VQ UP http://www.svntree. com/index. php?route=product/search=73 2-26-3 2,4,6-tris(tert- butyl)phenol NL NL https://toxnet.nlm.nih.gov/cgi- bin/sis/search2/r?dbs+hsdb:(a)term+(ฎrn+(ฎrel+732-26-3 2,4,6-tris(tert- butyl)phenol 25 grams 98% http://tcichemicals.com/eshop/en/us/commoditv/T0359/ 2,4,6-tris(tert- butyl)phenol VQ UP http://www.thsci.com/732-26-3.html 2,4,6-tris(tert- butyl)phenol VQ UP http://www.wonder-chem.com/product/310061.html VQ-varied quantities UP - unknown purity NL- not listed information Vendors also offer commercial/retail products that are mixtures of several chemicals, including 2,4,6- TTBP. Table 3 below shows products containing 2,4,6-TTBP at various concentrations and in proprietary blends available for general consumer purchase online. This list is provided for informational purposes only. EPA and its employees do not endorse any of the products or companies. Page 10 of 18 ------- Table 3. List of Products Available in Commerce Product Description and Price Reference Arctic Cat, Inc. Arctic Cat Fuel Injector Cleaner Fuel additive, conditioner, and stabilizer 12 ounces - $8.99 http://arcticcatlubricants.com/wp- content/uploads/2014/04/10144-Arctic-Cat- Fuel-lniector-Cleaner-07092015.pdf BG BG CF5 Fuel System Treatment Fuel system treatment 11 ounces - $14.78 https://www.amazon.com/BG%ADCF5%ADFuel %ADSystem%ADTreatment/dp/B005GDZPCY Champion Brands, LLC CHAMPION ฎ Fuel Stabilizer Fuel additive and stabilizer 8 ounces-$5.23 96 ounces - $62.76 http://championbrands.com/MSDS/4205M- Champion%20Fuel%20Stabilizer%20MSDS.pdf Cyclo Industries, Inc. C-290/292 Fuel Stabilizer Fuel additive and stabilizer 96 ounces - $58.56 http://cvclo.com/wp- content/uploads/2015/12/C290- C292 SDS Mav2014.pdf Eurol Lubricants Briggs and Stratton Fuel Fit Fuel additive, conditioner, and stabilizer 8 ounces-$16.84 http://www.centralspares.co.uk/files/downloa ds/BS992380%20Briggs%20and%20Stratton%2 0fuel%20fit.pdf Fuelcare, LTD Octamar LI-5 Plus Fuel preservative 34 ounces - $24.37 https://www.fuelcare.eom/pdf/octamarmsds.p df Gold Eagle - WERCS Sta-Bil Fuel Stabilizer Fuel additive and stabilizer 8 ounces-$15.00 10 ounces - $12.00 32 ounces - $21.00 40 ounces - $20.00 128 ounces - $75.00 1 gallon - $63.00 http://www.homedepot.com/catalog/pdflmag es/a6/a6e7aabl-al83-46c9-a3c6- f590e516a377.pdf Rislone Rislone ฎ Fuel Injector Cleaner with Upper Cylinder Lubricant Fuel additive, conditioner, and stabilizer 6 ounces - $3.18 72 ounces - $48.00 https://www.whatsinproducts.com/files/brand s pdf/1396211702.pdf SKF Maintenance Products LGEM 2 Bearing lubricant 14 ounces - $27.36 http://www.skf.com/us/products/lubrication- solutions/lubricants/safetv-data- sheets/index.html 5. Uses Industrial Uses As noted above, for the 2016 CDR period, data reported to EPA indicate that this chemical is processed as a reactant or intermediate in the basic organic chemical manufacturing sector. Additionally, both commercial and consumer uses were reported in the category fuels and related products. Industry has reported to EPA that 2,4,6-TTBP has historically been used as a reactant, an intermediate, a product in organic chemical manufacturing, and as an antioxidant in plastic and resin manufacturing. Commercial and Consumer Uses As noted previously, for the 2016 CDR period, both commercial and consumer uses were reported to EPA in the category fuels and related products. Page 11 of 18 ------- 2,4,6-TTBP has been noted as an ingredient in automobile fuel injector cleaners, as well as in lubricant additives and fuel additives (as an antioxidant) in gasoline and jet fuel11. As indicated in Table 1 and Table 3, some of these fuel additive products are available to consumers for automotive, marine or miscellaneous small engine uses. Potential Other Uses In 2008, Environment Canada reported in its Screening Assessment of 2,4,6-TTBP that the substance had historically been used as a lubricant additive and it was currently used in Canada as a fuel, oil, and gasoline additive. It was also reported that several additional use pattern codes and corresponding applications were noted in 2001 and 2007 surveys, including: feedstock fuels, chemical intermediates, pesticides, fertilizers, salt for deicing, solvents, cutting fluids, aerosol propellants, hydraulic fluids, lubricants and additives, cleaning/washing agents and additives, plant protection products, agricultural products, explosives, antioxidants, corrosion inhibitors, tarnish inhibitors, scavengers, and anti-scaling agents12,13. According to the Convention for the protection of the Marine Environment (OSPARCommission) in 2006, possible applications of 2,4,6-TTBP in Denmark, Norway and Sweden include a chemical intermediate in the production of antioxidants used in rubber and plastic, a lubricating agent in the transportation sector, a by-product in the production of 4-tert-butylphenol, as an additive for gasoline and fuel oil distillate, and in the offshore sector14. From 1998 to 2014 the Swedish Chemicals Agency flow analysis for chemical substances listed 2,4,6- TTBP in a category of 52 "butylphenols" used in 2763 products; 440 of which are consumer specific products15. According to the Substances in Preparation in Nordic Countries (SPIN) database, 2,4,6-TTBP has been reportedly used in industrial use (NACE) classifications between 2001 and 2014 for: Wholesale and retail trade and repair of motor vehicles (NACE Code G45), Manufacture of machinery and equipment (NACE Code C28), 11 DeLima Associates. Consumer Product Information Database. https://www.whatsinproducts.eom/chemicals/view/l/4995/000732-26-3/Polvolefin%20alkvl (accessed December 16, 2016) and U.S. National Institutes of Health ToxNet Toxicology Data Network, http://toxnet.nlm.nih.gov (accessed December 20, 2016) 12 Environment Canada & Health Canada, Screening Assessment for the Challenge - Phenol, 2,4,6-tris(l,l-dimethylethyl)- (2,4,6-tri-tert-butylphenol). November 2008, https://www.ec.gc.ca/ese-ees/92E21475-4289-446B-BCDA- E3E71BB93EF2/batch2 732-26-3 en.pdf 13 November 17, 2001. Canadian Environmental Protection Act, 1999 - Notice with Respect to Certain Substances on the Domestic Substances List. Canada Gazette: Part I. 135:46; 4194. 14 Convention for the Protection of the Marine Environment of the North Atlantic (OSPAR), 2,4,6-tri-tert-butylphenol, (OSPAR Commission, 2006 update) 274/2006, http://www.ospar.org/documents?v=6977 15 Swedish Chemicals Agency (KEMI). Flow analysis for chemical substances - butyl phenols. (http://webapps.kemi.se/flodesanalvser/FlodesanalvserSchema.aspx?SchemalD=1401; accessed December 16, 2016) Page 12 of 18 ------- Sale, maintenance and repair of motor vehicles and motorcycles; retail sale of automotive fuel (NACE Code 50), Construction (NACE Code 45), Manufacture of machinery and equipment (NACE Code 29), and Manufacture of coke, refined petroleum products, and nuclear fuel (NACE Code 23)16 According to a 2010 study of products in Norway, 2,4,6-TTBP was used in these applications: Additive in fuel, oil, gasoline, and lubricants, Phenolic resins (rubber/ink), Chemical intermediate (starting material for synthesis of 2,6-di-tert-butyl-4-methoxylphenol - antioxidant), and Additive to plastics (polymeric construction compounds used for flooring, pavement, sports grounds, drainage pipes, stabilizer for diene rubber, vulcanized rubber)17 Although importation, manufacture, and use of 732-36-3 is banned in Japan, the Japanese based National Institute of Technology and Evaluation found that 2,4,6-TTBP has been used as an antioxidant and additive (limited to those for lubricating and fuel oils) and in lubricating oils18,19. The Australian Government Department of Health conducted a recent assessment under the National Industrial Chemicals Notification and Assessment Scheme that concluded the chemical may be used in Australia as an additive for hydrocarbon fuels and a component of industrial lubricants20. One vendor listed in Table 1 (Shandong Kanghong International Trade Company Limited) markets 2,4,6-TTBP as potentially being used for: antioxidant in rubber, plastics, and oil use in latex manufacture (borealis group) heat stabilizer for polyethylene, polypropylene, and high impact polystyrene21 16Substances in Preparations in Nordic Countries, http://www.spin2000.net/spinmyphp/7pich732263 (accessed December 12, 2016) "Lambert, N., Rostock, C., Bonden, A. (2010). Dodecyl- and tri-tert-butylphenol in Products in Norway. Climate and Pollution Agency, http://www.miliodirektoratet.no/old/klif/publikasioner/2744/ta2744.pdf 18Government of Japan. 2007. Evaluation of Chemical Substances and Regulations of their Manufacture, etc. Cabinet Order No. 322 of 2007 "Environment Canada & Health Canada, Screening Assessment for the Challenge - Phenol, 2,4,6-tris(l,l-dimethylethyl)- (2,4,6-tri-tert-butylphenol). November 2008, https://www.ec.gc.ca/ese-ees/92E21475-4289-446B-BCDA- E3E71BB93EF2/batch2 732-26-3 en.pdf 20Australian Government Department of Health. 2016. National Industrial Chemicals Notification and Assessment Scheme Environmental Tier II Assessment for Phenol, 2,4,6-tris(l,l-dimethylethyl), https://www.nicnas.gov.au/chemical- information/imap-assessments/imap-assessments/tier-ii-environment-assessments/2-4-6-tri-tert-butvlphenol 21eTrade Asia website. Shandong Kanghong International Trade Company Limited order for 732-26-3. (http://www.etradeasia.com/products detail/0/1011138/4133/2 4 6 tri tert butvlphenol CAS 732 26 3 Pharmaceutic al lntermediate.html: accessed December 19, 2016) Page 13 of 18 ------- Another vendor (Shanghai Yancui Import and Export Co., Ltd.) markets 2,4,6-TTBP (known as Antioxidant Sonox 246 or Antioxidant 744) as suitable for use in natural and synthetic rubbers, glues, polyolefins plastics, and the main raw material of efficient phosphite antioxidants22. 6. Disposal of Waste and Recycling/Recovery 2,4,6-TTBP is not listed as a hazardous waste under the Resource Conservation and Recovery Act (RCRA). USEFUL TYPES OF INFORMATION This document presents a summary of information currently available to EPA on this chemical. EPA is interested in obtaining information to more fully characterize the manufacturing, processing, distribution, disposal, and use of this chemical, to inform the development of the exposure and use assessment for this chemical, and to inform any subsequent risk management efforts. For example, EPA is interested in obtaining information on: the functional uses for this chemical; what types of products contain this chemical; which industry sectors use this chemical; what volume of the chemical is used; which uses have been discontinued or phased out; exposure scenarios for this chemical; and in which articles this chemical is found. 22Shanghai Yancui Import and Export Co., Ltd. Product details. (http://www.chinaseniorsupplier.com/Environment/Catalvsts Chemical Auxiliary Agents/401209807/ANTIQXIDANT SON OX 246.html: accessed December 12, 2016) Page 14 of 18 ------- APPENDIX: SOURCES CONSULTED U.S. EPA Chemical Inventory https://www.epa.gov/tsca-inventory U.S. EPA ChemView https://iava.epa.gov/chemview TRI P2 information https://www.epa.gov/toxics-release-inventorv-tri-program/pollution-prevention-p2-and-tri U.S. EPA HPV HC (access through Chemical Data Access Tool - CDAT) https://java.epa.gov/oppt chemical search/ U.S. EPA HPVIS and HPV HC (access through Chemical Data Access Tool - CDAT) https://java.epa.gov/oppt chemical search/ DfE Alternatives Assessments https://www.epa.gov/saferchoice/design-environment-alternatives-assessments Safer Chemical Ingredients List https://www.epa.gov/saferchoice/safer-ingredients Green Chemistry awards https://www.epa.gov/greenchemistry/presidential-green-chemistry-challenge-winners Greener products and services https://www.epa.gov/greenerproducts/identify-greener-products-and-services Pollution Prevention https://www.epa.gov/p2/pollution-prevention-case-studies https://www.epa.gOv/p2/grant-programs-pollution-prevention#sra https://www.epa.gov/p2/pollution-prevention-tools-and-calculators U.S. EPA InertFinder https://iaspub.epa .gov/apex/pesticides/f?p=101:l: U.S. EPA Pesticide Chemical Search https://iaspub.epa .gov/apex/pesticides/f?p=CH EM ICALSEARCH:1:0::NQ:1:: U.S. EPA Endocrine Disruptor Screening Progmrn https://www.epa.gov/ingredients-used-pesticide-products/endocrine-disruptor-screening- program-tier-l-assessments U.S. EPA Hgzgrdous Wgste https://www.epa.gOv/hw/learn-basics-hazardous-waste#regulations U.S. EPA Superfund chemicgl dgtg mgtrix https://www.epa.gov/superfund/superfund-chemical-data-matrix-scdm-query U.S. EPA Hgzgrdous Air Pollutgnts https://www.epa.gov/haps/initial-list-hazardous-air-pollutants-modifications U.S. EPA Significgnt New Alterngtives Policy (SNAP) https://www.epa.gov/snap U.S. EPA Volgtile Orggnic Compounds https://www.epa.gov/indoor-air-qualitv-iaq/technical-overview-volatile-organic- compounds#definition U.S. EPA Toxic gnd priority pollutgnts under the Clegn Wgter Act https://www.epa.gOv/eg/toxic-and-priority-pollutants-under-clean-water-act#toxic Page 15 of 18 ------- U.S. EPA Contaminant Candidate list under the Safe Drinking Water Act https://www.epa.gOv/ccl/contaminant-candidate-list-3-ccl-3#chemical-list U.S. EPA IRIS Assessment https://cfpub.epa.gov/ncea/iris2/atoz.cfm U.S. EPASffS https://iaspub.epa.gov/sor internet/registry/substreg/searchandretrieve/substancesearch/search. do U.S. EPA Chemical and Product Categories (CPCat) Database https://actor.epa.gov/cpcat/faces/home.xhtml U.S. National Library of Medicine ChemlDplus https://chem.sis.nlm.nih.gov/chemidplus/ U.S. National Library of Medicine Hazardous Substance Data Bank (HSBD) https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm U.S. Department of Health & Human Services Household Products Database https://hpd.nlm.nih.gov/index.htm OSHA Chemical Hazards and Toxic Substances https://www.osha.gov/SLTC/hazardoustoxicsubstances/index.html NIOSH Workplace Safety and Health Topics Chemicals http://www.cdc.gov/niosh/topics/chemical.html NIOSH Pocket Guide to Chemical Hazards http://www.cdc.gov/niosh/npg/npgdcas.html CPSC Chemicals http://www.cpsc.gov/en/Research--Statistics/Chemicals/ CPSC FHSA https://www.cpsc.gov/Business--Manufacturing/Business-Education/Business-Guidance/FHSA- Requirements/ Food and Drug Administration List of Databases http://www.fda.gov/Forlndustrv/FDABasicsforlndustry/ucm234631.htm NTP (National Toxicology Program) Substances studied by NTP http://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status Department of Energy Protective Action Criteria Database http://energy.gov/ehss/protective-action-criteria-pac-aegls-erpgs-teels-rev-29-chemicals-concern- may-2016 California Department of Toxic Substances Control Toxics in Products http://www.dtsc.ca.gov/PollutionPrevention/ToxicslnProducts/index.cfm http://www.dtsc.ca.gov/SCP/CandidateChemicalsList.cfm http://www.dtsc.ca.gov/SCP/WhatlsAPriorityProduct.cfm California Office of Environmental Health Hazard Assessment Proposition 65 http://oehha.ca.gov/proposition-65/chemicals http://oehha.ca.gov/proposition-65/proposition-65-list California Office of Environmental Health Hazard Assessment Biomonitoring http://biomonitoring.ca.gov/chemicals California permissible exposure limits for chemical contaminants https://www.dir.ca.gov/title8/5155table acl.html California hazardous substance list Page 16 of 18 ------- https://www.dir.ca.gov/title8/339.html California Safe Cosmetics Program - list of chemical agents known or suspected to cause cancer or developmental or other reproductive harm. http://www.cdph.ca.gov/programs/cosmetics/Pages/default.aspx https://safecosmetics.cdph.ca.gov/search/Default.aspx Maine chemicals of high concern http://www.maine.gov/dep/safechem/highconcern/ Massachusetts Toxics Use Reduction Act (TURA) (link includes a link to Higher hazard substances list) http://www.mass.aov/eea/waste-mant-recyclina/toxics/toxic-use-reduction/toxics-use-reduction- act/ Massachusetts Complete list of TURA chemicals http://www.mass.gov/eea/agencies/massdep/toxics/tur/toxics-use-reduction-act-tura-reporting- and-fees.html Lowell Center for Sustainable Production Chemical, Policy and Science Initiative http://www.chemicalspolicv.org/chemicalspolicy.us.state.database.php Minnesota Department of Health Toxic Free Kids Act Chemicals of High Concern http://www.health.state.mn.us/divs/eh/hazardous/topics/toxfreekids/highconcern.html Michigan Environmental Health Topics http://www.michigan.gOv/mdhhs/0.5885.7-339-71548 54783 54784 74881-13050~.00.html New Hampshire Regulated Toxic Air Pollutants http://des.nh.gov/organization/commissioner/legal/rules/documents/env-al400.pdf New Jersey Right to Know Hazardous Substances http://web.doh.state.nj.us/rtkhsfs/rtkhsl.aspx Oregon Priority Persistent Pollutants (in water) http://www.deq.state.or.us/wq/SB737/ Oregon Pollutant Profiles http://www.deq.state.or.us/wq/SB737/docs/LegRpAtt420100601.pdf Oregon Reducing Toxics in Oregon http://www.oregon.gov/deq/Pages/ToxicsReduction.aspx Oregon Chemicals of Concern for Children's Health http://public.health.oregon.gov/HealthvEnvironments/HealthyNeighborhoods/ToxicSubstances/Pa ges/childrens-chemicals-of-concern.aspx Pennsylvania Department of Labor and Industry Hazardous Substance List http://www.pacode.com/secure/data/034/chapter323/chap323toc.html Rhode Island Air Resources - Air Toxics http://www.dem.ri.gov/pubs/regs/regs/air/air22 08.pdf Vermont Chemical Disclosure Program for Children's Products http://www.healthvermont.gov/enviro/chemical/cdp.aspx Washington Chemicals of High Concern to Children http://www.ecy.wa.gov/programs/hwtr/rtt/cspa/chcc.html Washington Children's Safe Products Act http://apps.leg.wa.gov/RCW/default.aspx?cite=70.240 Washington Department of Labor & Industries SHARP Publications http://www.lni.wa.gov/Safety/Research/Pubs/default.asp Page 17 of 18 ------- National Conference of State Legislatures http://www.ncsl.org/research/environment-and-natural-resources/state-chemical-statutes.aspx Canada Chemicals Portal http://chemicalsubstanceschimiques.gc.ca/index-eng.php EU ECHA website https://echa.europa.eu/ Australia NICNAS Chemical Information https://www.nicnas.gov.au/chemical-information Japan Chemical Risk Information Platform (CHIRP) http://www.nite.go.jp/en/chem/chrip/chrip search/systemTop OECD eChemPortal http://www.echemportal.org/echemportal/index?pagelD=Q&request locale=en Royal Society of Chemistry ChemSpider http://www.chemspider.com/ Stockholm Convention on Persistent Organic Pollutants http://chm.pops.int/TheConvention/ThePOPs/ListingofPOPs/tabid/25Q9/Default.aspx http://chm.pops.int/TheConvention/ThePOPs/ChemicalsProposedforListing/tabid/251Q/Default.as ฃX WHO IPCS (UN) http://www.who.int/ipcs/en/ Other-worker protection information http://www.dguv.de/ifa/gestis/gestis-internationale-grenzwerte-fuer-chemische-substanzen-limit- values-for-chemical-agents/index-2.jsp DeLima Associates Consumer Product Information Database (CPID) https://www.whatsinproducts.eom/chemicals/index/l SRC FatePointers Search Module PHYSPROP http://esc.syrres.com/fatepointer/search.asp Product and company websites Page 18 of 18 ------- |