United States
hi	Environmental Protection Agency

Office of Chemical Safety and
Pollution Prevention

Final Risk Evaluation for
n-Methylpyrrolidone

Systematic Review Supplemental File:
Data Extraction of Epidemiological Studies

CASRN: 872-50-4

December 2020


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The table below presents data summaries of epidemiological studies considered in hazard
characterization of NMP, as described in Section 3.2 of the Risk Evaluation. Studies that were
excluded due to an Unacceptable or Low data quality score are not included. The presented
exposure levels are values reported by the study authors and do not represent the PODs used for risk
estimation.

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Target Organ/
System

Outcome/ Endpoint

Study Population

Exposure

Results

Reference

Data Quality
Evaluation

Hepatic

Gamma glutamyl transferase
(GGT) expression (in IU/1) was
measured in serum as an
indication of liver function

Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60

Measured in air and via
biomonitoring, daily NMP
inhalation exposure median

0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39

mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)

Positive association
between NMP and GGT
expression, not statistically
significant

Haufroid et
al. 2014

Medium

Musculoskeletal/
Motor Function

Motor nerve conductivity
velocity

Cross-sectional, 14 factory
workers, Japan 2009, 5 day
study

Measured in air and via
biomonitoring, daily NMP
inhalation exposure means
of 0.14-0.26 ppm, with
maximum exposure of
0.80ppm, urine biomarkers

show NMP/creatinine
geometric mean of 0.081
mg/g creatinine

Positive association with
mean conductivity velocity,
not statistically significant

Nishimura
et al. 2009

Medium

Neurological/
Behavior

Self-rated depression scale

Cross-sectional, 14 factory
workers, Japan 2009, 5 day
study

Measured in air and via
biomonitoring, daily NMP
inhalation exposure means
of 0.14-0.26 ppm, with
maximum exposure of
0.80ppm, urine biomarkers

show NMP/creatinine
geometric mean of 0.081
mg/g creatinine

Negative association with

depression score,
statistically significant but
stated to not be associated
with NMP levels in logistic
regression models (data not
provided)

Nishimura
et al. 2009

Medium

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Target Organ/
System

Outcome/ Endpoint

Study Population

Exposure

Results

Reference

Data Quality
Evaluation

Renal

Serum creatinine (mg/dl) was
measured as an indicator of
kidney function

Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60

Measured in air and via
biomonitoring, daily NMP
inhalation exposure median

0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39

mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)

Positive association
between NMP and serum
creatinine levels, not
statistically significant

Haufroid et
al. 2014

Medium

Respiratory

Forced expiratory volume in
1st second of spirometry
(FEV1)

Cross-sectional, 8 male
workers, Switzerland 2006-
2011, ages 22-60

Measured in air and via
biomonitoring, daily NMP
inhalation exposure median

0.18 mg/m3, urine
metabolite biomarkers show
NMP/creatinine medians
before and after shift: 0.39

mg/g and 0.27 mg/g (5-
HNMP), 0.56 mg/g and 1.06
mg/g (2-HMSI)

Negative association
between NMP and FEV1,
not statistically significant

Haufroid et
al. 2014

Medium

Haufroid, V; Jaeger, VK; Jeggli, S; Eisenegger, R; Bernard, A; Friedli, D; Lison, D; Hotz, P. (2014). Biological monitoring and health effects of
low-level exposure to N-methyl-2-pyrrolidone: A cross-sectional study. Int Arch Occup Environ Health 87(6):663-74.
http://dx.doi.org/10.1007/s00420-013-09Q6-5
Nishimura, S; Yasui, H; Miyauchi, H; Kikuchi, Y; Kondo, N; Takebayashi, T; Tanaka, S; Mikoshiba, Y; Omae, K; Nomiyama, T. (2009). A cross-
sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Ind Health 47(4):355-62.
http: //dx. doi. org /10.2486/indhealth.47.355

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