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xvEPA
United States
Environmental Protection Agency
Office of Chemical Safety and
Pollution Prevention
Draft Risk Evaluation for
1-Bromopropane (1-BP)
Systematic Review Supplemental File:
Data Quality Evaluation of
Environmental Release and Occupational Exposure Data
CASRN: 106-94-5
Br
ch3
August 2019

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This document is a compilation of tables for the data extraction and evaluation for 1-
Bromopropane. Each table shows the data point or set or information element that was extracted
and evaluated from a data source in accordance with Appendix D of the Application of Systematic
Review in TSCA Risk Evaluations. If the source contains more than one data set or information
element, the review provides an overall confidence score for each data set or information element
that is found in the source. Therefore, it is possible that a source may have more than one overall
quality/confidence score.
The document includes sources that contain environmental release data that were evaluated by
EPA. However, environmental release data for the air pathway were not integrated because this
pathway was determined to be out of scope during development of the risk evaluation. See
Section 1.4 of the draft Risk Evaluation for further explanation.
Table of Contents
Page
Releases to the Environment	3
Occupational Exposure	11
Facility	64
Explanatory Notes
These explanatory notes provide context to understand the short comments in the data evaluation tables.
Domain
Metric
Description of Comments Field
Reliability
Methodology
Indicates the sampling/analytical methodology, estimation method, or
type of publication
Representativeness
Geographic Scope
Indicates the country of the study, publication, or underlying data
Applicability
Indicates whether the data are for a condition of use within scope of the
Risk Evaluation
Temporal Representativeness
Provides the year of study, publication, or underlying data
Sample Size
Describes the distribution of the sample or underlying data
Accessibility / Clarity
Metadata Completeness
Describes the completeness of the metadata
Variability and Uncertainty
Metadata Completeness
Indicates if study or publication addresses variability and uncertainty of
the data or information
2

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Releases to the Environment
3

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Source Citation:
Japanese Ministry of, Environment. 2017. 1-Bromopropane.
Type of Data Source
Releases to the Environment; Environmental Release Data;
Hero ID
3980936
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Environmental Media:	Air (majority, 93.7-99 percent ), 160 t to waste, 0.23 t to sewage
Annual Release Quantity (kg/yr):	1,300 t in 2011 under PRTR (5,000 t production and import)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Methodology not well described but the source is a trusted govt
publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
Low
X 1
x 2
x 2
x 1
2
2
2
3
EU
Uses are within scope
2011 estimates
Only a single data point
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Metadata limited
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Not discussed
Overall Quality Determination^
Medium

1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:
Camp, Inc. 2000. Final report: Beyond pollution prevention: Removal of organochlorines from industrial feedstocks and

processes in the Great Lakes Basin.
Type of Data Source
Releases to the Environment; Environmental Release Data;
Hero ID
3981054
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Various solvent uses
Annual Release Quantity (kg/yr):	1.5 MM lb in 2000 (Great Lakes Region)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Estimation methodology well described in doc
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US (Great Lakes)
Metric 3:
Applicability
High
x 2
2
Uses are within scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
2000 estimate
Metric 5:
Sample Size
Low
x 1
3
Only a single data point
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Medium
x 1
2
Contains some metadata
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
Not discussed
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:	CARB. 2011. Development of updated ARB solvent cleaning emissions inventories. Final Report: Agreement No. 06-322.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	2991110
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Number of Sites:
Use
Vapor Degreasing
Batch-loaded vapor degreaser,
aerosol cleaning process
Air
10.43 lb/employee-yr
Emission inventory
213
aerosol surface preparation process,
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
x 1
Release data methodology is well described and expected to be
accurate for the selected facilities
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US data (CA)
Metric 3:
Applicability
High
X
2
2
Release data are for OES within scope (with uncertainty on
the sub-category of degreaser)
Metric 4:
Temporal Representativeness
Medium
X
2
4
2001 report
Metric 5:
Sample Size
Medium
X
1
2
Emission inventory with over 200 samples, but distribution
characterized only by average and std dev. Values
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Study provides air emission factor without other metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3 Not discussed
Overall Quality Determination^
Medium
1.8

* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
6

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Source Citation:	Trinity Consultants. 2015. Emission Report, NPB Response Addendum.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	5018570
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Environmental Media:
Release Estimation Method:
Annual Release Quantity (kg/yr):
Number of Sites:
Use
Dry Cleaning, Vapor Degreasing, Spray Adhesive
Air
Solvent inventory or similar data
Variable depending on use, facility, and year
1 or more for each use
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
x 1
Release data methodology is well described and expected to be
accurate for the selected facilities
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US data
Metric 3:
Applicability
High
X
2
2
Release data are for OES within scope
Metric 4:
Temporal Representativeness
High
X
2
2
2009 - 2014 data
Metric 5:
Sample Size
Medium
X
1
2
Facility-level annual emission estimates provided for
years, but unclear whether selected facilities are representative
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Study provides air emission estimates without other metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3 Not discussed
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	U.S. EPA. 1981. AP-42. Compilation of air pollutant emission factors. Chapter 4. 6: Solvent degreasing.
Type of Data Source Releases to the Environment; Environmental Release Data;
Hero ID	3045012
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Release Source:
Environmental Media:
Release or Emission Factor:
Release Estimation Method:
Use
Vapor Degreasing
Waste solvent evaporation, solvent carryout, solvent bath evaporation,
spray evaporation, and agitation
Air
Cold cleaning VOC emissions are 3.2 - 57.1 percent of emissions com-
pared to OTVDs (see document for emission factor in kg/yr-unit)
Solvent purchase records
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Estimation methodology is described, AP-42 is a well estab-
lished document
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US data
Metric 3:
Applicability
High
X
2
2
Release data are for OES within scope
Metric 4:
Temporal Representativeness
Low
X
2
6
1981 publication
Metric 5:
Sample Size
Low
X
1
3
EF estimates not characterized by statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
EF are provided without other metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Not discussed
Overall Quality Determination^	Medium	2.1
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:
Newmoa,. 2001. Pollution prevention technology profile - Closed loop vapor degreasing.
Type of Data Source
Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3044986
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Vapor Degreasing
P2 Control & percent Efficiency:	98 percent when switching from OTVD to closed-loop degreaser
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Estimation method not specified
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X 1
x 2
x 2
x 1
1
2
4
3
US data
Estimate is for a use within scope
2001 publication
No statistics provided; single point estimate only
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Underlying data sources are not trasparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Not discussed
Overall Quality Determination^
Medium

2.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:
Wadden, R. A.,Scheff, P. A.,Franke, J. E.. 1989. Emission Factors for Trichloroethylene Vapor Degreasers. American Industrial

Hygiene Association Journal.
Type of Data Source
Releases to the Environment; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3051984
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Vapor Degreasing
P2 Control & percent Efficiency:	90 percent emission reduction for OTVD with LEV
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Estimation method not specified
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
Low
X 1
x 2
x 2
x 1
1
2
6
3
US data
Estimate is for a use within scope
Data more than 20 years old
Only a single estimate without additional information on dis-
tribution/statistics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
No metadata provided
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Not discussed
Overall Quality Determination^	Low	2.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Occupational Exposure
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Source Citation:	Toraason, M.,Lynch, D. W.,Debord, D. G.,Singh, N.,Nemhauser, J.. 2003. Assessment of DNA strand breaks in leukocytes
of workers occupationally exposed to 1-bromopropane. Toxicological Sciences.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1733747
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Use
Spray Adhesive
Liquid
Inhalation
0.2 - 271 ppm (site 1)4 - 42.7 ppm (site 2) [Individual data points not
available; only range reported]
41 workers (site 1) and 22 workers (site 2)
2
8-hr TWA
Sprayers and other activities
41 workers (site 1) and 22 workers (site 2)
Personal
worker breathing zone
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Data from HHE, but no description in this source (1 page sum-





mary only). Assumes a NIOSH method is used.
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US - because the data came from HHE, these sites would be





U.S. sites
Metric 3:
Applicability
High
x 2
2
Applies to condition of use within scope of risk eval
Metric 4:
Temporal Representativeness
Medium
x 2
4
Document published March 2003; date of sampling unknown
Metric 5:
Sample Size
Low
x 1
3
63 samples. No statistics provided.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Specifies data are PBZ TWA samples, but contains no other
metadata
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Source Citation:	Toraason, M.,Lynch, D. W.,Debord, D. G.,Singh, N.,Nemhauser, J.. 2003. Assessment of DNA strand breaks in leukocytes
of workers occupationally exposed to 1-bromopropane. Toxicological Sciences.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1733747
EVALUATION


Domain Metric
Rating
MWF* Score Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1 3 Does not address variability/uncertainty
Overall Quality Determination^
Medium
1.9

* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
unacceptable. Otherwise, the overall rating is based on the following scale:
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Source Citation:	Niosh,. 2007. Workers' exposures to n-propyl bromide at a printed electronics circuit assembly manufacturer.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3355604
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Vapor Degreasing
Liquid
Inhalation
1.3 - 14 ppm (day 1)1.6 - 21 ppm (day 2) [individual data points not
available]
5
1
PBZ,full-shift TWA
Operating vapor degreaser
5
Personal
worker breathing zone
when operating vapor degreaser on as-needed basis
6" refrigerated cooling coil. No LEV on vapor degreaser, but room has
canopy exhaust ventilation
Safety glasses and safety shoes
NIOSH method 1025
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
x 1
Study was conducted by Hanley. Describes use of GC-FID via
NIOSH method 1025, LOD of 0.5 ug
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope	High	x 1	1
Applicability	High	x 2	2
Temporal Representativeness	Medium x 2	4
Sample Size	Medium x 1	2
US
Applies to condition of use within scope of risk eval
Study conducted 8/16-18, 2004
5 samples. Range and average are reported, other statistics
not provided
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Source Citation:
Type of Data Source
Hero ID
Niosh,. 2007. Workers' exposures to n-propyl bromide at
Occupational Exposure; Monitoring Data;
3355604
a
printed electronics circuit assembly manufacturer.
EVALUATION
Domain
Metric Rating
MWF* Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium
X
1
2
Monitoring data include critical information about sample type
and exposure, but lacks additional metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^ Medium


1.7


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Niosh,. 2007. Workers' exposures to n-propyl bromide at a hydraulic power control component manufacturer.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3355621
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Vapor Degreasing
Liquid
Inhalation
0.078 - 2 ppm (PBZ)0.33 - 4 ppm (in-respirator)0.05 - 0.23 ppm (pre-
shift, exhaled)0.053 - 0.55 ppm (post-shift, exhaled)[individual data
points not available]
4
1
PBZ,full-shift TWA
Operating vapor degreaser, maintenance of equipment (removing sol-
vents)
4
Personal
worker breathing zone; in-mask
when operating vapor degreaser on as-needed basis
Refrigerated cooling coil, 14" freeboard height, chamber cover, no LEV
on degreaser but room maintained under negative pressure with general
exhaust ventilation
Half-mask air purifying respirator with combination organic vapor car-
tridges and HEPA filter, full face APF respirator with organic vapor
cartridge, PVA gloves, safety glasses, safety shoes
NIOSH method 1025
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
Study was conducted by Hanley. Describes use of GC-FID via
NIOSH method 1025
Domain 2: Representative
Metric 2:
Geographic Scope
High
x 1
1
US
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Source Citation:	Niosh,. 2007. Workers' exposures to n-propyl bromide at a hydraulic power control component manufacturer.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3355621
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
Medium
Medium
x 2
x 2
x 1
2
4
2
Applies to condition of use within scope of risk eval
Study conducted in 2004
4 samples. Range and average values reported, but distribution
not fully described
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Monitoring data include critical metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium

1.7

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Moon, H. I. l,Shin, S.,Byeon, S. H.. 2015. Exposure Monitoring and Health Risk Assessment of 1-Bromopropane as a Cleaning
Solvent in the Workplace. Human and Ecological Risk Assessment.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3576615
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Sampling:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Unknown Solvent Cleaning (automotive/electronic parts)
Liquid
Inhalation
central tendency - 82.1 mg/m3max - 214.8 mg/m3[provides only ranges/
GM at each workplace; individual data point not given]
50
10
Unknown - Likely area
LEV (most workplaces)
None (for most workers)
NIOSH method 1025
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Study conducted using NIOSH method
Domain 2: Representative
Metric 2:
Geographic Scope
Medium
X
1
2
Study conducted in Korea
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
Study conducted in 2005
Metric 5:
Sample Size
Medium
X
1
2
50 samples. Range and geometric mean reported for each data
set, but distribution not fully described
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Appear to be PBZ samples but includes no other metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
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— continued from previous page
Source Citation:	Moon, H. I. l,Shin, S.,Byeon, S. H.. 2015. Exposure Monitoring and Health Risk Assessment of 1-Bromopropane as a Cleaning
Solvent in the Workplace. Human and Ecological Risk Assessment.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3576615
EVALUATION
Domain
Metric
Rating MWF* Score
Comments

Overall Quality Determination^

Medium 1.9


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:
Type of Data Source
Hero ID
Atsdr,. 2016. Draft toxicological profile forl-bromopropane.
Occupational Exposure; Monitoring Data;
3827325
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Sites:
Number of Workers:
Type of Sampling:
Multiple
Manufacturing - Use (various)
Liquid
Inhalation
[summarizes results from other sources w/out providing individual data
points]Mfg: 0.9 - 170.5 ppm PBZUse: see source
1
37
Personal, area
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Unknown method used in the source cited
Domain 2: Representative
Metric 2:
Geographic Scope
Low
X
1
3
Exposure monitoring data for 1-BP mfg factory in China
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
High
X
2
2
2017 ATSDR report
Metric 5:
Sample Size
Low
X
1
3
37 samples. Data described as a range without further statis
tics
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Monitoring data are PBZ samples but provides no other meta-
data
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3 Does not address variability/uncertainty
Overall Quality Determination^
Medium
2.1

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
20

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Cdc,. 2016. Criteria for a recommended standard: Occupational exposure to 1-bromopropane.
Type of Data Source
Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827326
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Vapor Degreasing, Spray Adhesive
Number of Workers:	3,320 - 69,100 workers (8,300-40,300 workers for vapor degreaser, 400-
9,800 workers for foam mfg)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Cites a 2007 EPA source
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X
X
X
X
1
2
2
1
1
2
4
3
US data
Data for vapor degreasing and foam mfg
2016 document, but worker data from 2007
Unknown sample distribution
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
Cites a 2007 EPA source, provides a range only without other
metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium


1.9


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2014. Report on carcinogens: 1-Bromopropane.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3860561
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Multiple
Manufacture, Adhesives, Drycleaning, Aerosol Degreasing, Vapor De-
greasing, Other
Inhalation, dermal
ND - 380 ppm (adhesive use is highest, vapor degreasing lowest) [indi-
vidual data points not provided]
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Unknown method used in the source cited
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US data (primarily)
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
Data mostly 10-20 years old
Metric 5:
Sample Size
Low
X
1
3
Unknown sample distribution
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
Appear to be PBZ samples but includes no other metadata
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium
2.1
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
22

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	1999. Nomination of 1-bromopropane (1-BP) and 2-bromopropane (2-BP) for testing by the national toxicology program.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3860562
EXTRACTION
Parameter	Data
Life Cycle Stage:
Exposure Concentration (Unit):
Number of Samples:
Type of Measurement or Method:
Type of Sampling:
Use
0.05 - 135 ppm (OSHA) [individual data points not provided]
30
PBZ, 2-4 hr TWA
Personal
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X
1
3
Unknown method used in the source cited
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Low
X
X
X
X
1
2
2
1
1
2
4
3
US data
Use is within scope of RE
Data from 1999 publication
Unknown sample distribution
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
X
1
3
Data are PBZ short-term TWA, but provides no other meta-
data
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium


2.1


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
23

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2013. Report on carcinogens: monograph of 1-bromopropane.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3860563
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Multiple
Manufacture, Adhesives, Drycleaning, Aerosol Degreasing, Vapor De-
greasing, Other
Inhalation, dermal
ND - 380 ppm (adhesive use is highest, vapor degreasing lowest) [indi-
vidual data points not provided]
PBZ, 8- to 12-hr TWA
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Unknown method used in the source cited
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US data (primarily)
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
Data mostly 10-20 years old
Metric 5:
Sample Size
Low
X
1
3
Unknown sample distribution
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Medium
X
1
2
Includes only critical metadata
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium


2.0

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
24

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Osha,. 2010. Input received through web forum for identifying hazardous chemicals for which OSHA should develop exposure
reduction strategies.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3978176
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Route of Exposure:
Exposure Concentration (Unit):
Use
Dry cleaning
Inhalation
40 ppm (avg), cites Blando study
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Unknown method used in the source cited
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US study
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
High
X
2
2
Blando study cited appears to be within 10 yr
Metric 5:
Sample Size
Low
X
1
3
Unknown sample distribution
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
No description of metadata
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium


1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
25

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Dhhs,. 2017. Skin Notation (SK) Profile 1-Bromopropane.
Type of Data Source Occupational Exposure; Published Models for Exposures or Releases;
Hero ID	3986431
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Type of Measurement or Method:
Worker Activity:
Multiple
Various
Liquid
Dermal
skin permeation coefficient - 0.00904575 cm/hr, water solubility 2.45
mg/cm3
Experimental measurement
Experimental dermal dosing (Frasch et al. 2011) to simulate splash ex-
posure and occluded exposure, indicating substantial dermal penetration
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
Methodology of experimental data well described
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US study
Use is within scope of RE
Frasch study conducted in 2011
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X
1
1
Provides metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
High


1.3


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
26

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hanley, K. W.,Petersen, M.,Curwin, B. D.,Sanderson, W. T.. 2006. Urinary bromide and breathing zone concentrations of
1-bromopropane from workers exposed to flexible foam spray adhesives. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	607476
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Analytic Method:
Use
Spray Adhesive
Liquid
Inhalation
0.6 - 200 ppm TWA
30
2
Full shift TWA
Sprayer and non-sprayer
30
Personal
Breathing zone
Full shift
NIOSH method 1025
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Methodology of experimental data well described
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
Medium
X 1
x 2
x 2
x 1
1
2
4
2
US study
Use is within scope of RE
Study published in 2006
30 samples. Range and mean are reported, but distribution
not fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Monitoring data includes most critical info such as sample/
exposure type and some descriptive worker activity info, but
lacks other metadata
Continued on next page
27

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Hanley, K. W.,Petersen, M.,Curwin, B. D.,Sanderson, W. T.. 2006. Urinary bromide and breathing zone concentrations of
1-bromopropane from workers exposed to flexible foam spray adhesives. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	607476
EVALUATION


Domain Metric
Rating
MWF* Score Comments

Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1 2 Discuss variability between different worker activity
Overall Quality Determination^
High
1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
28

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Harney, J. M.,Nemhauser, J. B.,Reh, C. M.,Trout, D.,Schrader, S.. 2003. NIOSH Health Hazard Evaluation Report: HETA
No. 99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1379492
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
PPE:
Analytic Method:
Use
Spray Adhesive
Liquid
Inhalation
0.1-160 ppm
29
1
TWA
58-68.5 percent 1-BP
60
Personal and area
Various
Full shift
some respirator/glove use
NIOSH draft method for 1-BP
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Methodology of experimental data well described
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US study
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
2003
Metric 5:
Sample Size
High
X
1
1
29 samples. Individual data points provided to allow charac
terization of full distribution
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High	x 1	1 Provides metadata
Continued on next page
29

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Harney, J. M.,Nemhauser, J. B.,Reh, C. M.,Trout, D.,Schrader, S.. 2003. NIOSH Health Hazard Evaluation Report: HETA
No. 99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1379492
EVALUATION


Domain Metric
Rating
MWF* Score Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1 2 Discuss variability between different worker activity
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
unacceptable. Otherwise, the overall rating is based on the following scale:
30

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hanley, K. W.,Petersen, M. R.,Cheever, K. L.,Luo, L.. 2010. Bromide and N-acetyl-S-(n-propyl)-L-cysteine in urine from
workers exposed to 1-bromopropane solvents from vapor degreasing or adhesive manufacturing. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1689090
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Analytic Method:
Multiple
Vapor Degreasing; Adhesive Formulation
Liquid
Inhalation
0.07 - 18.9 ppm (range provided only)
42
6
Full shift TWA (8-10 hr)
"size, shape, and capacities of the vapor degreasers varied"
heavy aerospace components required large semi-automatic degreasers
equipped with LEV, smaller parts such as optical or electronic compo-
nents were cleaned with small manual units without mechanical hoists
and LEV" also see description for adhesive manufacturing
42
Personal
Breathing zone
Full shift
NIOSH method 1025
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Methodology of experimental data well described
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US study
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness High
x 2
2
2010
Metric 5:
Sample Size
Medium
x 1
2
42 samples. Range and mean are provided, but distribution





not fully characterized
Continued on next page
31

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Hanley, K. W.,Petersen, M. R.,Cheever, K. L.,Luo, L.. 2010. Bromide and N-acetyl-S-(n-propyl)-L-cysteine in urine from
workers exposed to 1-bromopropane solvents from vapor degreasing or adhesive manufacturing. International Archives of
Occupational and Environmental Health.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1689090
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium x 1
2
Monitoring data includes most critical info such as sample/
exposure type and some descriptive worker activity info, but
lacks other metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium x 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High
1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
32

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hanley, K. W.,Petersen, M. R.,Cheever, K. L.,Luo, L.. 2009. N-acetyl-S-(n-propyl)-l-cysteine in urine from workers exposed
to 1-bromopropane in foam cushion spray adhesives. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1689272
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Analytic Method:
Use
Spray Adhesive
Liquid
Inhalation
0.635 - 121 ppm (range only)
30
2
Full shift TWA
Includes some worker description such as sprayers,
seamtresses
30
Personal
Breathing zone
Full shift
NIOSH method 1025
non-sprayers,
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Methodology of experimental data well described
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope	High
Applicability	High
Temporal Representativeness	High
Sample Size	Medium
X 1	1 US study
X 2	2 Use is within scope of RE
X 2	2 2009
X 1	2	30 samples. Range and mean are reported, but distribution
not fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Sample type, exposure type and some worker activity are
known, but not all metadata are provided
Continued on next page
33

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— continued from previous page
Source Citation:
Type of Data Source
Hero ID
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Hanley, K. W.,Petersen, M. R.,Cheever, K. L.,Luo, L.. 2009. N-acetyl-S-(n-propyl)-l-cysteine in urine from workers exposed
to 1-bromopropane in foam cushion spray adhesives. Annals of Occupational Hygiene.
Occupational Exposure; Monitoring Data;
1689272
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Medium X 1	2 Discuss variability between different worker activity
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
34

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ichihara, G.,Li, W.,Ding, X.,Peng, S.,Yu, X.,Shibata, E.,Yamada, T.,Wang, H.,Itohara, S.,Kanno, S.,Sakai, K.,Ito,
H.,Kanefusa, K.,Takeuchi, Y.. 2004. A survey on exposure level, health status, and biomarkers in workers exposed to
1-bromopropane. American Journal of Industrial Medicine.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1717475
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Analytic Method:
Manufacture
Manufacture
Liquid
Inhalation
0.9 - 106.8 ppm
37
1
TWA
Operators manually poured materials into reaction pots, checked tem-
perature, and poured distilled solution into 20L plastic containers. They
were also responsible for mixing the solvent with sodium hydrogen car-
bonate. 1-BP was 96.74 percent purity
37
Personal
Breathing zone
Full shift
GS-MS
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Methodology of experimental data well described
Domain 2: Representative





Metric 2:
Geographic Scope
Low
X 1
3
China
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
x 2
4
2003
Metric 5:
Sample Size
High
x 1
1
37 samples. Individual data points provided to allow charac-
terization of distribution
Continued on next page
35

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:	Ichihara, G.,Li, W.,Ding, X.,Peng, S.,Yu, X.,Shibata, E.,Yamada, T.,Wang, H.,Itohara, S.,Kanno, S.,Sakai, K.,Ito,
H.,Kanefusa, K.,Takeuchi, Y.. 2004. A survey on exposure level, health status, and biomarkers in workers exposed to
1-bromopropane. American Journal of Industrial Medicine.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1717475
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X 1
1
Provides metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High

1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
36

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Kawai, T.,Takeuchi, A.,Miyama, Y.,Sakamto, K.,Zhang, Z. W.,Higashikawa, K.,Ikeda, M.. 2001. Biological monitoring of
occupational exposure to 1-bromopropane by means of urinalysis for 1-bromopropane and bromide ion. Biomarkers.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1733873
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
PPE:
Analytic Method:
Use
Metal Surface Cleaning and Painting
Liquid
Inhalation
1.42 ppm (GM) (actual data points not provided)
33
1
metal surface preparation
33
Personal
Breathing zone
gloves
GC
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Methodology of experimental data well described
Domain 2: Representative
Metric 2:	Geographic Scope	Medium	x 1
Metric 3:	Applicability	High	x 2
Metric 4:	Temporal Representativeness	Medium	x 2
Metric 5:	Sample Size	Medium	x 1
2 Japan
2 Use is within scope of RE
4 2000
2	33 samples. Mean and max values reported, but distribution
not fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Low	X 1	3 Study is for PBZ sampling, but no other metadata provided
Domain 4: Variability and Uncertainty
Continued on next page
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— continued from previous page
Source Citation:	Kawai, T.,Takeuchi, A.,Miyama, Y.,Sakamto, K.,Zhang, Z. W.,Higashikawa, K.,Ikeda, M.. 2001. Biological monitoring of
occupational exposure to 1-bromopropane by means of urinalysis for 1-bromopropane and bromide ion. Biomarkers.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1733873
EVALUATION
Domain Metric
Rating
MWF* Score Comments
Metric 7: Metadata Completeness
Medium
X 1 2 Discuss variability between different worker activity
Overall Quality Determination^
Medium
1.8

* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Eisenberg, J.,Ramsey, J.. 2010. Evaluation of 1-Bromopropane Use in Four New Jersey Commercial Dry Cleaning Facilities.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1737891
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
PPE:
Analytic Method:
Use
Drycleaning
Liquid
Inhalation
17-40 ppm
7
4
Full shift TWA
Operator; cashier
7
Personal
Breathing zone
Full shift
None
NIOSH method 1025
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
x 1
Methodology of experimental data well described
Domain 2: Representative
Metric 2
Metric 3
Metric 4
Metric 5
Geographic Scope	High	x	1	1
Applicability	High	x	2	2
Temporal Representativeness	High	x	2	2
Sample Size	High	x	1	1
US study
Use is within scope of RE
2010
7 samples. Individual data points allow characterization of full
distribution
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High	x 1	1 Provides metadata
Domain 4: Variability and Uncertainty
Continued on next page
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— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Eisenberg, J.,Ramsey, J.. 2010. Evaluation of 1-Bromopropane
Occupational Exposure; Monitoring Data;
1737891
Use in
Four New Jersey Commercial Dry Cleaning Facilities.
EVALUATION
Domain
Metric
Rating MWF*
Score
Comments

Metric 7; Metadata Completeness
Medium x 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High
1.1


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Reh, C. M.,Mortimer, V. D.,Nemhauser, J. B.,Trout, D.. 2002. NIOSH Health Hazard Evaluation Report: HETA No.
98-0153-2883, Custom Products, Inc. Mooresville, NC.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1737898
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Use
Spray Adhesive
Liquid
Inhalation
60 - 381.2 ppm
80
1
Full shift TWA
Highest exposure was in the Covers dept, followed by Assembly dept
and Saw dept; adhesive contains 60-70 percent 1-BP
70
Personal
Breathing zone
Full shift
spray booth
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	X 1	1 Methodology of experimental data well described
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US study
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
2002
Metric 5:
Sample Size
High
X
1
1
80 samples. Distribution fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	High	x 1	1 Provides metadata
Continued on next page
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— continued from previous page
Source Citation:	Reh, C. M.,Mortimer, V. D.,Nemhauser, J. B.,Trout, D.. 2002. NIOSH Health Hazard Evaluation Report: HETA No.
98-0153-2883, Custom Products, Inc. Mooresville, NC.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1737898
EVALUATION


Domain Metric
Rating
MWF* Score Comments
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1 2 Discuss variability between different worker activity
Overall Quality Determination^
High
1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
unacceptable. Otherwise, the overall rating is based on the following scale:
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Source Citation:
Osha,. 2013. OSHA/NIOSH hazard alert:
1-bromopropane.
Type of Data Source
Occupational Exposure; Monitoring Data;

Hero ID
2347177

EXTRACTION


Parameter

Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Use
Various
Liquid
Inhalation
0.08 - 254 ppm (range only)
122
6
Full shift TWA
Ref. multiple other studies
EVALUATION



Domain
Metric
Rating
MWF* Score Comments
Domain 1: Reliability



Metric 1:
Methodology
Low
X 1 3 Cites other sources for exposure data; methodology unknown
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US study
Metric 3: Applicability
High
X
2
2
Use is within scope of RE
Metric 4: Temporal Representativeness
Medium
X
2
4
Age of data ranging from 2003 - 2010
Metric 5: Sample Size
Medium
X
1
2
122 samples, only range of values are reported
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
Low
X
1
3
Full-shift monitoring data, other metadata not provided
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
Medium
X
1
2
Discuss variability between different worker activity
Overall Quality Determination^
Medium


1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Hsia,. 2010. Petition to add n-propyl bromide to list of hazardous air pollutants regulate under section 112 of the Clean Air
Act [with cover letter date 10/28/2010].
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3045668
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Use
Various
Liquid
Inhalation
up to 150 ppm (no actual data points, but has description of data ranges
for various uses incl. hand wiping, aerosol solvents, etc - see p.23/31)
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Cites other sources for exposure data; methodology unknown
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US study
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
Report is dated 2010, but actual age of monitoring data is






unclear - appears to be between 10-20 years
Metric 5:
Sample Size
Medium
X
1
2
Contains a range of statistics without actual data points.
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Medium
X
1
2
Data sources are cited and generally described, but not fully






transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Medium
X
1
2
Limited discussion of variability
Overall Quality Determination^
Medium
1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Osha,. 2017. Hazard alert: 1-Bromopropane.
Type of Data Source Occupational Exposure; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3978174
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Engineering Control & percent Exposure Reduction:
PPE:
Use
Various
Liquid
Inhalation
Cites various Hanley, NIOSH, and Blando studies and references a range
of exposure concentration in those studies
Discusses various controls such as isolation, ventilation, etc.
Indicates that polyvinyl alcohol or multiple-layer laminates glove should
be used
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	Low	X 1	3 Cites other sources for exposure data; methodology unknown
Domain 2: Representative
Metric 2: Geographic Scope
High
X
1
1
US study
Metric 3: Applicability
High
X
2
2
Use is within scope of RE
Metric 4: Temporal Representativeness
Medium
X
2
4
Age of data ranging from 2003 - 2010
Metric 5: Sample Size
Medium
X
1
2
122 samples, only range of values are reported
Domain 3: Accessibility/Clarity





Metric 6: Metadata Completeness
Low
X
1
3
Full-shift monitoring data, other metadata not provided
Domain 4: Variability and Uncertainty





Metric 7: Metadata Completeness
Medium
X
1
2
Discuss variability between different worker activity
Overall Quality Determination^
Medium


1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:
Type of Data Source
Hero ID
Harney, J. M.,Hess, J.,Reh, C. M.,Trout, D.. 2002. Health hazard evaluation report no. HETA 2000-0410-2891, STN Cusion
company, Thomasville, North Carolina.
Occupational Exposure; Monitoring Data;
3970574
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
Analytic Method:
Use
Spray Adhesive
Liquid
Inhalation
1st visit: 41.3 - 143 ppm for sprayers2nd visit: 7.7 - 34.9 ppm for sprayer-
sAdditional data for other workers
32
1
Full shift TWA
HHE describes worker activities at STN Cushion Company. Cushion
is assembled by gluing together and hand pressing pieces of cut flexi-
ble foam. Adhesive is spray-applied using a compressed air spray gun.
Adhesive is Whisper Spray (Imperial Adhesives, Cincinnati, OH) which
contains 55 percent 1-BP by weight.
84 (32 participated in survey)
Full shift TWA
Spray stations and other locations
Full shift
Enclosure of spray tables
NIOSH draft method for 1-BP
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
NIOSH publication
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US study
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
x 2
4
HHE conducted in 2000
Continued on next page
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— continued from previous page
Source Citation:	Harney, J. M.,Hess, J.,Reh, C. M.,Trout, D.. 2002. Health hazard evaluation report no. HETA 2000-0410-2891, STN Cusion
company, Thomasville, North Carolina.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3970574
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Metric 5: Sample Size
High
X 1
1
32 samples. Distribution fully characterized
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X 1
1
Provides metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High

1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Eisenberg, J.,Ramsey, J.. 2010. Health hazard evaluation report no. HETA 2008-0175-3111, Evaluation of 1-Bromopropane
use in four New Jersey commercial dry cleaning facilities.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3970603
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Drycleaning
Liquid
Inhalation
17 - 40 ppm (full shift TWA); short-term data also available
7
4
Full shift TWA
See study for description of machine type and worker activities at each
of 4 facilities visited
7
Full shift TWA
Breathing zone of operators and cashiers
Full shift
None
None used
NIOSH method 1025
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	x 1	1 NIOSH publication
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US study
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
High
X
2
2
HHE conducted in 2008
Metric 5:
Sample Size
High
X
1
1
7 samples. Individual data points allow characterization of full
distribution
Domain 3: Accessibility/Clarity
Continued on next page
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— continued from previous page
Source Citation:	Eisenberg, J.,Ramsey, J.. 2010. Health hazard evaluation report no. HETA 2008-0175-3111, Evaluation of 1-Bromopropane
use in four New Jersey commercial dry cleaning facilities.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3970603
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Metric 6: Metadata Completeness
High
X 1
1
Provides metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Hanley, K. W.,Petersen, M.,Curwin, B. D.,Sanderson, W. T.. 2006. Urinary bromide and breathing zone concentrations of
1-bromopropane from workers exposed to flexible foam spray adhesives, Part3. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3974876
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Analytic Method:
Use
Spray Adhesive
Liquid
Inhalation
sprayers: 92 ppm (geometric mean)other jobs: 11 ppm (geometric
mean) (only ranges and GM provided)
30
2
Full shift TWA
Sprayers constructed polyurethane foam furniture cushions using spray
adhesives. Non-sprayers included glue lilne leads, sewing machine oper-
ators, wrappers, pillow stuffers, and foam and cloth cutters. Exposure
among non-sprayers occurred as a result of overspray and solvent drift.
30 (13 sprayers, 17 non-sprayers)
Full shift TWA
Breathing zone
Full shift
NIOSH method 1025
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
Methodology of experimental data well described
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US study
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
x 2
4
2005 data
Metric 5:
Sample Size
Medium
x 1
2
30 samples. Range and mean are reported, but distribution
not fully characterized
Continued on next page
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— continued from previous page
Source Citation:	Hanley, K. W.,Petersen, M.,Curwin, B. D.,Sanderson, W. T.. 2006. Urinary bromide and breathing zone concentrations of
1-bromopropane from workers exposed to flexible foam spray adhesives, Part3. Annals of Occupational Hygiene.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3974876
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X 1
2
Full-shift TWA data with some worker activity info, but not
all metadata are provided
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Medium
X 1
2
Discuss variability between different worker activity
Overall Quality Determination^
High

1.6


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	OSHA. 2013. 1-Bromopropane Manufacturing Site Visit Report " Company A. Draft " Final. Prepared by Project Enhance-
ment Corporation.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5018532
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Manufacture
Manufacture
Liquid
Inhalation
ND - 2.61 ppm
18
1
PBZ short-term and TWA
Product loading, sampling
3
Personal
Breathing zone
Short-term and Full shift
Approx. once per shift during product loading and/or sampling
Richter and Dopak samplers; smart hose for truck loading; laboratory
fume hood or nitrogen purge dry box
Respirator worn during product loading
PV2061
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High x 1
Sampling method is approved by OSHA
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US facility
Metric 3:
Applicability
High
X
2
2
Mfg is within scope of RE
Metric 4:
Temporal Representativeness
High
X
2
2
2013 data
Metric 5:
Sample Size
High
X
1
1
Limited number of samples, but all individual data points are
provided to allow characterization of distribution
Continued on next page
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— continued from previous page
Source Citation:	OSHA. 2013. 1-Bromopropane Manufacturing Site Visit Report " Company A. Draft " Final. Prepared by Project Enhance-
ment Corporation.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5018532
EVALUATION




Domain Metric
Rating
MWF*
Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
X 1
1
Monitoring data includes metadata such as sample type, dura-
tion, etc.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High

1.2


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:
Type of Data Source
Hero ID
OSHA. 2013. 1-Bromopropane, Inspection/Case File Summary.
Occupational Exposure; Monitoring Data;
5018566
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Vapor Degreasing, Spot Cleaning, Spray Adhesive, Cold Cleaning
Liquid
Inhalation
Varies, depends on inspected facility
Multiple
19
Full shift TWA
Varies for each inspected facility
Multiple
Personal and area
Breathing zone; facility area
Full shift
Varies
Varies
Varies
Not known
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
OSHA document
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US facilities
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
Inspection date ranges from 1998 - 2011
Metric 5:
Sample Size
High
X
1
1
Individual data points are provided, which allow characteriza-
tion of distribution
Domain 3: Accessibility/Clarity
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— continued from previous page
Source Citation:
Type of Data Source
Hero ID
OSHA. 2013. 1-Bromopropane, Inspection/Case File Summary.
Occupational Exposure; Monitoring Data;
5018566


EVALUATION
Domain
Metric
Rating MWF*
Score
Comments

Metric 6; Metadata Completeness
Medium x 1
2
Monitoring data includes only critical metadata, e.g. sample
type and exposure type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High
1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	U.S. EPA. 2006. Significant new alternatives policy (SNAP) - Risk screen on substitutes for ozone depleting substances for
adhesive, aerosol solvent, and solvent cleaning applications. Proposed substitute: n-Propyl bromide.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	2991016
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Vapor Degreasing, Aerosol Degreasing
Liquid
Inhalation
Varies, depends on source of data
Multiple
Multiple
TWA and short-term
Varies for each facility; sometimes not specified
Multiple
Personal and area
Breathing zone; facility area
Full shift
Varies
Varies
Varies
Not known
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Low
X 1
3
Sampling and analytical method used by individual company
not specified
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US facilities
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Low
x 2
6
Date of data appears to vary, many are prior to 2003, some
aerosol degreasing data are from 1998
Metric 5:
Sample Size
High
x 1
1
Individual data points are provided, which allow characteriza-
tion of distribution
Continued on next page
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— continued from previous page
Source Citation:
Type of Data Source
Hero ID
U.S. EPA. 2006. Significant new alternatives policy (SNAP) - Risk screen on substitutes for ozone depleting substances for
adhesive, aerosol solvent, and solvent cleaning applications. Proposed substitute: n-Propyl bromide.
Occupational Exposure; Monitoring Data;
2991016
EVALUATION
Domain
Metric Rating MWF*
Score
Comments

Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness Medium x 1
2
Monitoring data includes only critical metadata, e.g. sample
type and exposure type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness Low x 1
3
Does not address variability/uncertainty
Overall Quality Determination^ Medium
2.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
57

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Source Citation:	NIOSH. 2001. Evaluation of Solvent Exposures from the Degreaser. Trilthic Inc., IN.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	3044962
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Vapor Degreasing
Liquid
Inhalation
0.01 - 0.63 ppm
27
1
Full shift TWA
Placing parts in metal wire basket, lower basket into degreasing solution,
raising basket and allow it to dry
75 - 85
Personal and area
Breathing zone; facility area
Full shift
Varies
Room enclosure, LEV
Nitrile gloves and splash-proof goggles
NIOSH draft method for 1-BP
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	x 1	1 NIOSH publication
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US facilities
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
Medium
X
2
4
2000 data
Metric 5:
Sample Size
High
X
1
1
Individual data points are provided, which allow characteriza-
tion of distribution
Domain 3: Accessibility/Clarity
Continued on next page
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— continued from previous page
Source Citation:
Type of Data Source
Hero ID
NIOSH. 2001. Evaluation of Solvent Exposures from the Degreaser. Trilthic Inc., IN.
Occupational Exposure; Monitoring Data;
3044962
EVALUATION
Domain
Metric Rating
MWF* Score
Comments

Metric 6; Metadata Completeness Medium
X 1 2
Monitoring data includes only critical metadata, e.g. sample
type and exposure type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness Low
X 1 3
Does not address variability/uncertainty
Overall Quality Determination^ High
1.6


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
59

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Source Citation:	OSHA. 2018. OSHA CEHD Monitoring Data provided by Stephen Schayer to Greg Macek on 6/21/2018.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5018565
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Type of Sampling:
Sampling Location:
Exposure Duration:
Use
Vapor Degreasing
Liquid
Inhalation
Scored at project level?
50
15
TWA
Not described; some job titles include "parts washer/vapor degreaser"
Personal
Breathing zone
TWA and short-term
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Domain 1: Reliability
Metric 1: Methodology	High	x 1	1 OSHA samples
Domain 2: Representative
Metric 2:
Geographic Scope
High
X
1
1
US facilities
Metric 3:
Applicability
High
X
2
2
Use is within scope of RE based on job title description
Metric 4:
Temporal Representativeness
High
X
2
2
2013 - 2016 data
Metric 5:
Sample Size
High
X
1
1
Individual data points are provided, which allow characteriza-
tion of distribution
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness	Medium X 1	2 Monitoring data includes only critical metadata, e.g. sample
type and exposure type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 Does not address variability/uncertainty
Continued on next page
60

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— continued from previous page
Source Citation:	OSHA. 2018. OSHA CEHD Monitoring Data provided by Stephen Schayer to Greg Macek on 6/21/2018.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	5018565
EVALUATION
Domain	Metric	Rating MWF* Score	Comments
Overall Quality Determination^	High	1.3
* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:	Blando, J. D.,Schill, D. P.,De La Cruz, M. P.,Zhang, L.,Zhang, J.. 2010. Preliminary study of propyl bromide exposure
among New Jersey dry cleaners as a result of a pending ban on perchloroethylene. Journal of the Air and Waste Management
Association.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1619253
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Physical Form:
Route of Exposure:
Exposure Concentration (Unit):
Number of Samples:
Number of Sites:
Type of Measurement or Method:
Worker Activity:
Number of Workers:
Type of Sampling:
Sampling Location:
Exposure Duration:
Exposure Frequency:
Engineering Control & percent Exposure Reduction:
PPE:
Analytic Method:
Use
Drycleaning
Liquid
Inhalation
ND - 54.55 ppm
26
4
8-hr TWA
Operator, clerk, seamstress
2/shop
Personal and Area
Breathing Zone; shop areas
Full shift
Varies
None
None
NIOSH 1025
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
NIOSH publication
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US facilities
Metric 3:
Applicability
High
x 2
2
Use is within scope of RE
Metric 4:
Temporal Representativeness
High
x 2
2
2010 study; data may have been collected in 2008
Metric 5:
Sample Size
High
x 1
1
Limited number of samples, but individual data points allow
characterization of distribution
Continued on next page
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— continued from previous page
Source Citation:	Blando, J. D.,Schill, D. P.,De La Cruz, M. P.,Zhang, L.,Zhang, J.. 2010. Preliminary study of propyl bromide exposure
among New Jersey dry cleaners as a result of a pending ban on perchloroethylene. Journal of the Air and Waste Management
Association.
Type of Data Source Occupational Exposure; Monitoring Data;
Hero ID	1619253
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X 1
2
Monitoring data includes only critical metadata, e.g. sample
type and exposure type
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
High
X 1
1
Discuss uncertainty in sampling and variability in the observed
data
Overall Quality Determination^
High

1.1


* MWF = Metric Weighting Factor
I If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
63

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Facility
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Source Citation:	Niosh,. 2007. Workers' exposures to n-propyl bromide at a printed electronics circuit assembly manufacturer.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3355604
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Vapor Degreasing
Small capacity open-top vapor degreaser used on as-needed basis for sol-
dering and potting activities to clean flexible and rigid parts of PCB.
Degreaser contains a hand actuated spray wand and nozzle to supple-
ment the vapor cleaning (Pioneer Circuits Inc. in santa Ana, CA)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
NIOSH HHE
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
Study conducted 8/16-18, 2004
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data source, assessment method, results and assumptions are
clearly described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	Niosh,. 2007. Workers' exposures to n-propyl bromide at a hydraulic power control component manufacturer.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3355621
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Chemical Concentration:
Use
Vapor Degreasing
1 vapor degreaser shared by a dozen workers in Teflon and Refurbishing
dept. and is used on as-needed basis. A medium capacity open-top
vapor degreasing is located in a small ventilated room. An additional
iquid solvent wash tank is located outside in a chemical shed.
94 percent
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
NIOSH HHE
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
Study conducted in 2004
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Data source, assessment method, results and assumptions are
clearly described.
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:
Type of Data Source
Hero ID
Atsdr,. 2016. Draft toxicological profile forl-bromopropane.
Facility; Completed Exposure or Risk Assessments;
3827325
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Manufacture
Manufacture and Import
Mfg via dehydration of propanol with bromine or hydrogen bromide
5,000 mt produced in US in 2006, growing 15-20 percent per yrlmport
- 10.9 and 10.3MM lb in 2007 and 2011, respectively (total brominated
derivatives of acryclic hydrocarbons)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
ATSDR report
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
2017 report, but data are from 2006-2007
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data/sources not well described
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:
Cdc,. 2016. Criteria for a
recommended standard: Occupational exposure to 1-bromopropane.
Type of Data Source
Facility; Reports for Data
or Information Other than Exposure or Release Data;
Hero ID
3827326

EXTRACTION


Parameter

Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Vapor Degreasing, Spray Adhesive
Number of Sites:	2,540 - 9,280 businesses (vapor degreaser - 500-2,500; foam mfg - 100-
280)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Cites a 2007 EPA source
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
Data from 2007
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
underlying data/sources not well described
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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Source Citation:	2017. PubChem: 1-Bromopropane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860484
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacture and Import
Mfg by treatment of hydroxyl compound with a bromide and sulfuric
acid
2002: 1-10MM lb (IUR)
41 chemical vendors
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Process description from Kirk-Othmer; PV from IUR
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Mfg is within scope
Data from 2006
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Clearly cites the source of information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation: 2014. Report on carcinogens: 1-Bromopropane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID 3860561
EXTRACTION
Parameter
Data



Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacture and Import
Describes possible use as spot remover in textile industry
2012 - 15.3 MM lb. 2013 - 9.2 MM lb import, 15.6MM lb export (CDR)
21 mfg world-wide, incl. at least 1 in US (SRI, 2012)
EVALUATION
Domain Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1: Methodology
High
X 1
1
Info from CDR and SRI
Domain 2: Representative
Metric 2: Geographic Scope
Metric 3: Applicability
Metric 4: Temporal Representativeness
Metric 5: Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
Mfg is within scope
Data from 2012-2013
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
High
x 1
1
Clearly cites the source of information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High

1.3

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	1999. Nomination of 1-bromopropane (1-BP) and 2-bromopropane (2-BP) for testing by the national toxicology program.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860562
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacture and Import
1 mfg est. an additional 2.5MM lb may be used/yr as cleaning agent
1
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
X 1
1
OSHA publication
Domain 2: Representative





Metric 2:
Geographic Scope
High
X 1
1
US
Metric 3:
Applicability
High
x 2
2
Mfg is within scope
Metric 4:
Temporal Representativeness
Medium
x 2
4
1999
Metric 5:
Sample Size
N/A

N/A
No Comment.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
Low
x 1
3
Underlying data/sources not well described
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium
1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
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Source Citation:	2013. Report on carcinogens: monograph of 1-bromopropane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860563
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Number of Sites:
Manufacture
Manufacture and Import
1-BP is produced by reacting n-propyl alcohol with hydrogen bromide
and then removing the water that forms"
mfg: 1-10MM lb (2006)Import: 10.3MM lb (2011) (CDR data)
At least 1 US mfg in 2012 (SRI, 2012)
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
High
X
1
1
Info from CDR and SRI
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Mfg is within scope
Metric 4:
Temporal Representativeness
High
X
2
2
Data from 2012
Metric 5:
Sample Size
N/A


N/A
No Comment.
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
High
X
1
1
Clearly cites the source of information
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
Does not address variability/uncertainty
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
72

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Source Citation:	Echa,. 2014. Draft results of the 6th prioritisation of the SVHCs on the Candidate List with the objective to recommend
priority substances for inclusion in Annex XIV.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3970684
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Manufacture
Manufacture and Import
Some volume used as an intermediate in mfg of chemicals. May also be
used in some laboratory analyses.
1,000 ton/yr in EU.
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
ECHA document, but methodology not well described
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
Low
N/A
X 1
x 2
x 2
2
2
6
N/A
EU
Mfg and uses within scope
Year of data unknown
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Source of info unknown
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^	Low	2.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
73

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Source Citation:
Oehha,. 2007. Occupational health hazard risk assessment project for California: Identification of chemicals of concern,

possible risk assessment methods, and examples of health protective occupational air concentrations.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3982225
EXTRACTION

Parameter
Data
Life Cycle Stage:	Manufacture
Life Cycle Description (Subcategory of Use):	Manufacture and Import
Total Annual U.S. Volume (and percent of PV):	1-10M lb in 2004
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Data appear to come from IUR
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Mfg is within scope
Data from 2004
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Only some metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
High

1.6

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
74

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Dhhs,. 2017. Skin Notation (SK) Profile 1-Bromopropane.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3986431
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Degreasing
Chemical Concentration:	95.5 percent (degreasing solvent) (Sclar, 1999)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
Concentration came from one specific site visit
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
Data from 1999
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Little to no metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Type of Data Source
Hero ID
Cdph,. 2017. 1-Bromopropane.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3969295
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Aerosol degreasing, other misc. uses
Indicates potential use of 1-BP in coatings for pipes and other fixtures,
and use of spray aerosols containing 1-BP to clean auto parts. Source
also lists a number of products containing 1-BP
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Low
X 1
3
Source of data and methodology unclear
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2016 publication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Little to no metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium
1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
76

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S, E. P. A.. 2001. Guide to industrial assessments for pollution prevention and energy efficiency.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3827322
EXTRACTION

Parameter
Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Degreasing
Process Description:	Source describes cold cleaning and vapor degreasing, generation of sol-
vent waste stream, recycling of cleaning medium (see Section 5)
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
EPA document
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
2001 publication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Little to no metadata
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Does not address variability/uncertainty
Overall Quality Determination^
Medium

1.8

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	The Massachusetts Toxics Use Reduction Institute, University of Massachusetts Lowell. 2006. Five chemicals alternatives
assessment study.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3981053
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Degreasing
1-BP is the most widely used alternative to PERC for vapor degreasing.
1-BP has lower surface tension thatn PERC which makes it favorable for
cleaning complex geometric parts. nPB cost $13/gal, 3 times as much
as PERC.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
TURA document
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
Use is within scope
2006 publication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A


N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A


N/A
N/A - qualitative information
Overall Quality Determination^
High


1.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
78

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	The Massachusetts Toxics Use Reduction Institute, University of Massachusetts Lowell. 2006. Five chemicals alternatives
assessment study.
Type of Data Source Facility; Published Models for Exposures or Releases;
Hero ID	3981053
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Dry cleaning
Dry cleaning machine load capacity: 35-65 lb (avg: 50 lb) in CA, and
45-60 lb (avg: 53 lb) in MA. In most forms of dry cleanings, spotting
agents are usually used before dry cleaning takes place. Source also
indicates recycling of dry cleaning solvent via a distillation unit.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
TURA document
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
x 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2006 publication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
79

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Echa,. 2015. Background document for 1-bromopropane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3970681
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Misc.
1-BP may
be used
in some
laboratory analyses
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
ECHA document
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
X 1
x 2
x 2
2
2
2
N/A
EU
Use is within scope
2015 publication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High

1.2

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
80

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 1995. Guidance document for the halogenated solvent cleaner NESHAP.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3827323
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Degreasing
Describes batch v. in-line machine configurations and emission controls
relating to NESHAP compliance (not 1-BP specific)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
High
x 1
1
EPA document
Domain 2: Representative





Metric 2:
Geographic Scope
High
x 1
1
US
Metric 3:
Applicability
High
x 2
2
Use is within scope
Metric 4:
Temporal Representativeness
Low
x 2
6
1995 document
Metric 5:
Sample Size
N/A

N/A
No Comment.
Domain 3: Accessibility/Clarity




Metric 6:
Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty




Metric 7:
Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
81

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hsia,. 2011. Model rule for solvent defreasing.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982145
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Degreasing
"TCE is typically recycled as part of a controlled process, leaving only
filters and sludge to be disposed of. Aqueous systems require much
greater water usage and produce large amounts of contaminated wastew-
ater" Airless degreasers have major operational disadvantages...and are
not an option in many applications. A number of companies in PA clean
the narrow tubes they mfg in large (40-50 feet) custom-built equipment.
No airless system is available that meets such requirements."
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
HSIA
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
x 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2011 document
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
82

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hesis,. 2016. 1-bromopropane (n-propyl bromide): Health hazard alert.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3982242
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Misc.
Indicates use of 1-BP when applying "coatings to pipes or other fixtures"
and in " spray aerosols used to clean auto parts". Source identifies com-
mercial products containing 1-BP (adhesives, cleaners and degreasers,
and other solvents)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
California Dept of Public Health
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
x 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2016 document
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
83

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
Echa,. 2011. Comments on
Annex XV Dossier for identification of a substance as SVHC and response to these comments.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID
3970682

EXTRACTION


Parameter

Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Misc.
U.S. aerospace industry identifies the use of 1-BP in solvents, vapor de-
greasing and cleaning. A company in the Netherlands identifies majority
of 1-BP used as an intermediate. Enviro Tech and several other compa-
nies in UK indicate current use of 1-BP as direct replacement for TCE
in vapor degreasing equipment (in use for several years). 1 co. in Ger-
many indicates use in closed loop cleaning system with short cleaning
times and usage of 3-4 LT per day. Most customers of PPC in France
use their products as intermediates in pharmaceutical or agrochemical
industries. They have very few customers for 1-BP, all of which are in
pharmaceutical industry. 1-BP is produced in well-closed equipment at
PPC and monitoring data within past 5 years were all below 10 ppm.
Based on information collected by REACH Consortium for Brominated
substances, 69 percent of 1-BP is used for intermediate purposes. One
UK company states that stabilized 1-BP is also "used in asphalt testing
as a replacement for TCE. This is a laboratory test whereby 1-BP dis-
solves the bitumen out of asphalt to separate it from the aggregate and
the solvent then distilled off and collected for re-use."
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability





Metric 1:
Methodology
Medium
X 1
2
ECHA comment summary document; comments submitted by





various companies in Europe
Domain 2: Representative





Metric 2:
Geographic Scope
Medium
X 1
2
Europe
Metric 3:
Applicability
High
x 2
2
Use is within scope
Metric 4:
Temporal Representativeness
High
x 2
2
2011 document
Metric 5:
Sample Size
N/A

N/A
No Comment.
Continued on next page
84

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
— continued from previous page
Source Citation:
Type of Data Source
Hero ID
Echa,. 2011. Comments on Annex XV Dossier for identification of a substance as SVHC and response to these comments.
Facility; Reports for Data or Information Other than Exposure or Release Data;
3970682
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A N/A
N/A - qualitative information
Overall Quality Determination^
High 1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Echa,. 2015. Opinion of the Member State Committee on the sixth draft recommendation of the priority substances and
Annex XIV entries.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3970683
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Misc.
Source indicates 1-BP does not have consumer uses, and is primarily
used as intermediates in the EU
EVALUATION
Domain
Metric
Rating MWF* Score
Comments
Domain 1: Reliability
Metric 1: Methodology
Medium x 1
2	ECHA comment summary document; comments submitted by
various companies in Europe
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
Medium
High
High
N/A
x 1
x 2
x 2
2
2
2
N/A
Europe
Use is within scope
2015 document
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High

1.3


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
86

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Raymond, L. W.,Ford, M. D.. 2007. Severe illness in furniture makers using a new glue: 1-bromopropane toxicity confounded
by arsenic. Journal of Occupational and Environmental Medicine.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	1025819
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Operating Days per Year and Batches per Day:
Possible Physical Form:
Chemical Concentration:
Use
Spray adhesive
Glue was applied by spraying in aerosol form and directly by hand and
by brush
8 hr/day, 5 day/wk
Liquid
70 percent
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
published journal article
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
x 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
2007 study
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
87

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ntp, Cerhr. 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of 1-
bromopropane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	1519109
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Manufacture
Manufacture and Import
Mfg by reacting n-propyl alcohol with hydrogen bromide and removing
the water that forms. Also can be produced by dehydration of propanol
with bromine or hydrogen bromide in presence of sulfur catalyst. Cites
other sources on exposure concentration ranges
1.5 MM lb in 2000 produced, 2.8 MM lb imported
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
US govt publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
x 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
2003 publication, but data are older
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Niosh,. 1997. Control of health and safety hazards in commercial drycleaners: chemical exposures, fire hazards, and ergonomic
risk factors.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3044963
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Use
Dry cleaning
70 percent dry cleaning shops have 1-4 employees, 17 percent have 5-9
employees. Typical process begins when garments are brought to the
shop. They are initially tagged for identification. Prior to spotting or
being loaded into machines, they are inspected and sorted. See source
for detailed process description.
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
US govt publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Low
N/A
x 1
x 2
x 2
1
2
6
N/A
US
Use is within scope
1997
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
Medium
1.7
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
89

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Hsia,. 2010. Petition to add n-propyl bromide to list of hazardous air pollutants regulate under section 112 of the Clean Air
Act [with cover letter date 10/28/2010].
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3045668
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Various
General use information as aerosol solvents (incl. lubricants, coatings),
adhesives, and vapor degreasing.
use of a solvent - growing at 15-20 percent /yr in US (5,000 metric
tonnes)
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
x 1
2
Unknown methodology
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
x 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
PV data appears to be for 2007
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.5
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
90

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	U.S, E. P. A.. 2017. Preliminary Information on Manufacturing, Processing, Distribution, Use, and Disposal: 1-Bromopropane.
Support document for Docket EPA-HQ-OPPT-2016-0741.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3827328
EXTRACTION
Parameter	Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Chemical Concentration:
Use
Various
Use Dossier provides indication of various uses
Use Dossier indicates 2015 PV to be 25.8 MM lb (2016 CDR)
See Use Dossier for concentration for each product
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X
1
1
EPA publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X
X
X
1
2
2
1
2
2
N/A
US
Use is within scope
2016 CDR data
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A


N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A


N/A
N/A - qualitative information
Overall Quality Determination^
High


1.0


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
91

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	2017. Chemical data reporting: 1-bromo-propane.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860454
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Total Annual U.S. Volume (and percent of PV):
Use
Various
Chemview data, provides specific names of companies that manufacture
or import 1-BP from 2012 CDR
Based on 2012 CDR data, national aggregate PV is 15 MM lb
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
EPA publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
x 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2012 CDR data
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.0
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
92

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Ashford, R. D.. 2001. Ashford's Dictionary of Industrial ChemicalsN-propyl bromide.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	3860433
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Process Description:
Possible Physical Form:
Manufacture
Manufacture
Ashford Chemical Dictionary indicates 1-BP production is from n-
propanol with ydrochromic acid (alcohol bromination)
Liquid
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
x 1
1
Ashford Chemical Dictionary
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
x 1
x 2
x 2
1
2
4
N/A
US
Mfg is within scope
2001 edition
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
N/A

N/A
N/A - qualitative information
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
N/A

N/A
N/A - qualitative information
Overall Quality Determination^
High
1.3
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
93

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	IRTA. 2016. Alternative Compliance Strategies for Enclosed and Conveyorized Vapor Degreasers under a Prohibition of
Trichloroethylene. Draft..
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5018567
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Degreasing
Number of Sites:	100 vacuum degreasers and 800 conveyorized degreasers using 1-BP
EVALUATION






Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability






Metric 1:
Methodology
Low
X
1
3
Data sources and estimation techniques not specified
Domain 2: Representative






Metric 2:
Geographic Scope
High
X
1
1
US
Metric 3:
Applicability
High
X
2
2
Use is within scope
Metric 4:
Temporal Representativeness
High
X
2
2
2016 document
Metric 5:
Sample Size
Low
X
1
3
Estimate not characterized by statistics
Domain 3: Accessibility/Clarity





Metric 6:
Metadata Completeness
Low
X
1
3
Underlying data and methods not fully transparent
Domain 4: Variability and Uncertainty





Metric 7:
Metadata Completeness
Low
X
1
3
Variability and uncertainty not addressed
Overall Quality Determination^
Medium


1.9

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
94

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Enviro Tech International. 2017. RE: 1-Bromopropane, Docket ID number EPA-HQ-OPPT 2016-0741. The Use of 1-
bromopropane (nPB) in the Dry Cleaning Industry.
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5018569
EXTRACTION
Parameter
Data
Life Cycle Stage:
Life Cycle Description (Subcategory of Use):
Total Annual U.S. Volume (and percent of PV):
Use
Dry cleaning
<50,000 lb 1-BP used in dry cleaning sector in 2015, <40,000 lb in 2016,
Number of Sites:

and likely <30,000 lb in 2017
9 converted PERC machines and 19 DrySolv machines were in service
in 2016
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X 1
2
Data from company expected to be knowledgeable with the
sector, but industry data may present potential biase
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
X 1
x 2
x 2
1
2
2
N/A
US
Use is within scope
2017 public comment
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
x 1
2
Data comes from a company likely knowledgeable with the in-
formation, but underlying data are not fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
x 1
3
Variability and uncertainty not addressed
Overall Quality Determination^
High

1.5

* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
95

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:
U.S. EPA. 2013. Use and market profile for 1-bromopropane in
vapor degreasers, spray adhesives, and aerosol solvents.
Type of Data Source
Facility; Reports for Data or Information Other than Exposure
or Release Data;
Hero ID
3045699

EXTRACTION


Parameter
Data

Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Aerosol Degreasing
Number of Sites:	1,000 - 5,000 businesses used 1-BP-based aerosol solvents in 2002
EVALUATION





Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
High
X 1
1
US govt publication
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
Medium
N/A
X 1
x 2
x 2
1
2
4
N/A
US
Use is within scope
2013 publication, which cites data from a 2007 document
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Low
x 1
3
Underlying data and methods not fully transparent
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness	Low	X 1	3 Does not address variability/uncertainty
Overall Quality Determination^	Medium	1.8
* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.

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PEER REVIEW DRAFT - DO NOT CITE OR QUOTE
Source Citation:	Enviro Tech International. 2019. Personal communication between R. Morford (Enviro Tech International, Inc.) and D.
Parsons (U.S. EPA).
Type of Data Source Facility; Reports for Data or Information Other than Exposure or Release Data;
Hero ID	5261917
EXTRACTION
Parameter	Data
Life Cycle Stage:	Use
Life Cycle Description (Subcategory of Use):	Dry cleaning
Number of Sites:	8 dry cleaning establishments use 1-BP in 2019
EVALUATION
Domain
Metric
Rating
MWF*
Score
Comments
Domain 1: Reliability
Metric 1:
Methodology
Medium
X
1
2
Data from company expected to be knowledgeable with the
sector, but industry data may present potential biase
Domain 2: Representative
Metric 2:
Metric 3:
Metric 4:
Metric 5:
Geographic Scope
Applicability
Temporal Representativeness
Sample Size
High
High
High
N/A
XXX
1
2
2
1
2
2
N/A
US
Use is within scope
2019 communication
No Comment.
Domain 3: Accessibility/Clarity
Metric 6: Metadata Completeness
Medium
X
1
2
Data comes from a company likely knowledgeable with the in-
formation, but underlying data are not fully transparent as the
location of the specific establishments is not known
Domain 4: Variability and Uncertainty
Metric 7: Metadata Completeness
Low
X
1
3
Variability and uncertainty not addressed
Overall Quality Determination^
High


1.5


* MWF = Metric Weighting Factor
t If any individual metrics are deemed Unacceptable, then the overall rating is also unacceptable. Otherwise, the overall rating is based on the following scale:
High: > 1 to < 1.7; Medium: > 1.7 to < 2.3; Low: > 2.3 to < 3.
97

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