Pesticides Fact Sheet for Indaziflam


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PESTICIDE FACT SHEET

Name of Chemical: Indaziflam

Reason for Issuance: Conditional Registration

Date Issued: July 26, 2010

I.	DESCRIPTION OF CHEMICAL

Chemical Name: Indaziflam; N-[(lR,2S)-2,3-dihydro-2,6-dimethyl-lH-inden-l-yl]-6-[(lRS)-l-
fluoroethy 1 ]-1,3,5 -tri azine-2,4-di amine

Common Name: Indaziflam

EPA PC Code: 080818

Chemical Abstracts Service (CAS) Number: 950782-86-2
Year of Initial Registration: 2010
Pesticide Type: Herbicide
Chemical Class: Alkylazine

Mode of Action: Indaziflam controls weeds by inhibiting cellulose biosynthesis (CB Inhibitor)
Registrant: Bayer Environmental Science and Bayer Advanced

II.	USE PATTERNS AND FORMULATIONS

Application Sites: Indaziflam is a selective herbicide providing pre-emergence and post-
emergence (when indaziflam is formulated with 2,4-D, dicamba, mecoprop, and penoxsulam)
control of annual grasses and broadleaf weeds. Indaziflam is registered for application to
residential and commercial areas (lawns, ornamentals, and hardscapes including patios,
walkways, etc.), turf (parks, cemeteries, golf courses, sod farms, sports fields, and commercial
lawns), field grown ornamentals and Christmas trees, commercial nursery and landscape
plantings, and forestry sites.

Types of Formulations: Indaziflam is registered as EPA Reg. 432-RLNR (1501) BCS-
AA10717 Technical Herbicide (containing 95.8% indaziflam) and EPA Reg. 432-RUOI (1498)

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BCS-AA10717 2% MUP Herbicide (containing 2.0% indaziflam). Indaziflam is proposed for
use by commercial applicators (formulated in water soluble bags and added to turf fertilizer).
These proposed registrations include EPA Reg. 432-RUOO (1499) BCS-AA10717 20WSP
Herbicide (containing 20.0% indaziflam), EPA Reg. 432-RUOL (1495) BCS-AA10717 0.0142%
Plus Turf Fertilizer Herbicide (containing 0.0142% indaziflam), EPA Reg. 432-RUOA (1496)
BCS-AA10717 0.0213% Plus Turf Fertilizer Herbicide (containing 0.0213% indaziflam), and
EPA Reg. 432-RUOT (1497) BCS-AA10717 0.0284% Plus Turf Fertilizer Herbicide (containing
0.0284%) indaziflam). Indaziflam is proposed for residential use by non-commercial applicators
(formulated as a spray and a granule). These proposed registrations include EPA Reg. 72155-10
(89) Lawn 3FL Herbicide Concentrate / Ready to Spray (containing 0.25% indaziflam), EPA
Reg. 72155-ON (90) Lawn 3FL Herbicide Ready to Use (containing 0.0031%) indaziflam), and
EPA Reg.72155-OR (91) Lawn 3FL Herbicide Granule (containing 0.05% indaziflam).

Application Methods and Rates: Indaziflam may be applied through a variety of application
methods ranging from broadcast equipment to hand held equipment. Maximum annual
application rates range from 0.089 to 0.134 lbs. ai/acre/year.

III. PHYSICAL AND CHEMICAL PROPERTIES

l'h> Mavhcmical I'mperiies of liida/.iflam

Parameter

Value

Reference

Melting point/range

183 -184 °C indaziflam (pure substance)

Petition

pH (23 °C)

pH = 6.5 indaziflam (pure substance)
pH = 5.1 indaziflam (technical substance)

Administrative
Materials

Density

1.23 g/cm3 at 20 °C (both pure and technical
substance)



Water solubility (g/L at 20 °C)

pH 4: 0.0044
pH 9: 0.0028
Distilled water (pH 6.6-6.9): 0.0028



Solvent solubility (g/L at 20 °C)

Acetone: 55
Acetonitrile: 7.6
Dichloro methane: 150
Dimethyl sulfoxide: >250
Ethanol: 13.0
Ethyl acetate: 47
Heptane: 0.032
Toluene: 4.3



Vapor pressure

2.5 x 10"8 PA at 20 °C or 1.875 x 1010 mm Hg

6.8	x 10"8 PA at 25 °C or 5.1 x 1010 mm Hg

6.9	x 10"6 PA at 50 °C or 5.2 x 10"8 mm Hg



Henry's law constant

2.69 x 10-6 [Pa x m3/mol] at 20 °C



Dissociation constant (pKa)

3.5



Octanol/water partition coefficient
Log (K0w)

pH 2: 2.0

pH4, pH7 and pH9: 2.8



UV/visible absorption spectrum
methanol (nm)

^maxi = 213 nm / A = 1.428
?4nax2= 268 nm / A = 0.197
?4nax3 = 291 nm / A = 0.019



2

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IV. HUMAN HEALTH RISK

A summary of the human health effects and risk of indaziflam as assessed in the Agency
document titled "Indaziflam: Human Health Risk Assessment for Use of Indaziflam on Turf,
Golf Courses, Sod Farms, Christmas Tree Farms, Non-Crop Areas and Forestry" is provided
below.

The toxicology database is considered adequate for selecting toxicity endpoints for risk
assessment. The scientific quality is relatively high, and the toxicity is well-characterized for all
types of effects, including potential developmental, reproductive, immunologic and neurologic
toxicity. At this time the database is considered complete; however, the Agency is currently
evaluating issues related to volatilization of pesticides, including the use of route-to-route
extrapolation and assessment of inhalation exposure using oral studies, based on
recommendations of the FIFRA Scientific Advisory Panel following their December, 2009
meeting. The requirement of a 28- or 90-day inhalation toxicity study for this and other
pesticides will be re-visited when the Agency has completed its review.

Indaziflam has low acute toxicity via the oral (Toxicity Category III), dermal (Toxicity Category
III) and inhalation (Category IV) routes of exposure. It is not irritating to the eye or skin
(Toxicity Category IV) and is not a dermal sensitizer.

Summary of Acute Toxicity

Guideline No.

Study Type

MRlD(s)

Results

Toxicity Category

870.1100

Acute oral - rat

47443281

LD50 > 2000 mg/kg
(both sexes)

III

870.1200

Acute dermal - rabbit

47443282

LD50 > 2000 mg/kg
(both sexes)

III

870.1300

Acute inhalation - rat

47443283

LC50 > 2.3 mg/L
(both sexes)

870.2400

Acute eye irritation - rabbit

47443284

Non-irritant

870.2500

Acute dermal irritation - rabbit

47443285

Non-irritant

870.2600

Skin sensitization - guinea pig

47443286

Not a sensitizer
(Buehler method)

N/A

The nervous system is a target for indaziflam in rats and dogs. Degenerative neuropathology of
the brain, spinal cord and sciatic nerve was reported in the dog following both subchronic and
chronic oral exposure. Neuropathology in the dog was the most sensitive effect and was selected
as the endpoint for all exposure scenarios involving repeated exposure. In the rat, histopathology
of the brain and pituitary pars nervosa was observed following chronic exposure. Clinical signs
of neurotoxicity were observed in both species in several studies, which included rat adult and
developmental neurotoxicity studies. Decreased motor activity observed in the rat acute
neurotoxicity study was selected as the appropriate endpoint for acute oral toxicity.

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Degenerative renal effects were observed in the rat and mouse following chronic exposure.

Liver hypertrophy was observed in rats, and females showed liver histopathology. Thyroid
effects were observed in male rats following subchronic and chronic exposure but were
considered secondary to liver stimulation and occurred at significantly higher doses than those
selected for risk assessment (15-fold or greater), and therefore are not considered to be of
concern for pre- and/or postnatal development. Other effects observed following chronic
exposure were an increased incidence of atrophied or small seminal vesicles in male rats and in
female mice, an incidence of stomach erosions, and blood-filled ovarian cysts. Decreased body
weight gains were generally observed in the available studies. No systemic toxicity was
observed in a 28-day dermal toxicity study in the rat.

In the rat developmental toxicity study, decreased fetal weight was observed in the presence of
maternal effects that included decreased body weight and clinical signs of toxicity. No
developmental effects were observed in rabbits up to maternally toxic dose levels. Decreased
pup weight and delays in sexual maturation (preputial separation in males and vaginal patency in
females) were observed in the rat two-generation reproductive toxicity study, along with clinical
signs of toxicity, at a dose causing parental toxicity that included clinical signs and decreased
weight gain. In the developmental neurotoxicity study, transiently decreased motor activity
(PND 21 only) in male offspring was observed and was considered a potential neurotoxic effect.
It was observed at a dose that also caused clinical signs of neurotoxicity along with decreased
body weight in maternal animals.

There was no evidence of carcinogenicity observed in the two-year dietary rat or mouse
carcinogenicity bioassays and no evidence of genotoxicity in mutagenicity studies (reverse gene
mutation in bacteria, forward gene mutation in mammalian cells) or in vitro and in vivo
chromosomal aberration assays. Based on the lack of evidence of carcinogenicity or
genotoxicity, the Agency classified indaziflam as "Not likely to be carcinogenic to humans."

The toxicological profile is discussed in the table at the start of the next page:

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Tvpc

MR ID No. (year)/
Classification /Doses

Results

870.3100

90-Day oral
toxicity (rat)

47443287 (2005)
Acceptable/Guideline

0, 200, 5000 or 10,000

ppm in diet for 13 weeks

M: 0, 14, 338 or 689

mg/kg/day

F: 0, 16, 410 or 806

mg/kg/day

98.7% a.i.

NOAEL = 14/410 mg/kg/day M/F
LOAEL = 338/806 mg/kg/day M/F, based on:
in males at 338 mg/kg/day, increased TSH at
Week 3 and diffuse thyroid follicular cell
hypertrophy at Week 13; in females at 806
mg/kg/day, mortality (one female, sacrificed in
extremis with clinical signs, decreased motor
activity and gastric red foci), marginally
decreased body weights and decreased food
consumption.

870.3100

90-Day oral
toxicity (mouse)

47443288 (2005)

Acceptable/Guideline

0, 100, 500 or 1200 ppm
in diet for 13 weeks

M: 0, 19, 91 or 218
mg/kg/day;

F: 0, 23, 118 or 256
mg/kg/day

96.5% a.i.

NOAEL = 91/118 mg/kg/day M/F

LOAEL = 218/256 mg/kg/day M/F, based on
increased mortality and wasted appearance
(females), hunched posture in males and
females, decreased body weight/weight gain
and food consumption in males and females.

870.3150

90-Day oral
toxicity (dog)

47443289 (2008)

Acceptable/Guideline

0, 7.5, 15 or 30 mg/kg/day
by gavage

94.5-99.4% a.i.

NOAEL = 7.5 mg/kg/day M/F
LOAEL =15 mg/kg/day, based on axonal
degeneration in the brain, spinal cord and
sciatic nerve in males and females. At 30
mg/kg/day, 3 animals were sacrificed with
seizures by Day 30; all remaining group
animals were sacrificed on Day 36. Decreased
body weight gain and neuropathology were
observed.

870.3200

28-Day dermal
toxicity (rat)

47443290 (2006)

Acceptable/Guideline

0, 40, 200 or 1000
mg/kg/day applied to skin
5 days/week for 4 weeks
(22/23 total applications
inM/F)

90.32% a.i.

Systemic NOAEL = 1000 mg/kg/day
LOAEL = not determined (>1000 mg/kg/day)
Local dermal NOAEL = 1000 mg/kg/day
LOAEL = not determined (>1000 mg/kg/day).
Some indication of local dermal irritation was
observed at all doses but the findings were
transient and observed only in females, and
therefore were not considered adverse.

870.3700a

Prenatal

developmental in
(rat)

47443291 (2006)

Acceptable/Guideline

0, 10, 25 or 200
mg/kg/day by gavage in
0.5% aqueous
methylcellulose, GD 6
through 20

Maternal NOAEL = 25 mg/kg/day
LOAEL = 200 mg/kg/day based on decreased
body weight gain and food consumption.
Developmental NOAEL = 25 mg/kg/day
LOAEL = 200 mg/kg/day based on decreased
fetal body weights.

5

-------
Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Tvpc

MR ID No. (year)/
Classification /Doses

Results





94.5% a.i.



870.3700b

Prenatal

developmental in
(rabbit)

47443292 (2008)

Acceptable/Guideline

0, 10, 25 or 60 mg/kg/day
by gavage in 0.5%
aqueous methylcellulose,
GD 6 through 28

93.14% a.i.

Maternal NOAEL = 25 mg/kg/day
LOAEL = 60 mg/kg/day based on decreased
maternal body weight gain and food
consumption and macroscopic changes in the
liver in one doe.

Developmental NOAEL = 60 mg/kg/day
LOAEL = not established (>60 mg/kg/day).

870.3800

Reproduction and
fertility effects
(rat)

47443293 (2008)

Acceptable/Guideline

0, 150, 1000 or 8000 ppm
in the diet; F1 high dose
reduced to 4000 ppm at 5-
17 days' postweaning

Average P/Fi
consumption (note: high
dose not averaged due to
F1 dose reduction)

M: 0, 10.4, 69.3 or 560.1
mg/kg/day (P males) and
317.6 mg/kg/day (Fi
males, due to reduction in
dietary dose)

F: 0, 12.9, 85.2 or 656.2
mg/kg/day (P females)
and 355.2 mg/kg/day (Fi
females, due to reduction
in dietary dose)

Parental NOAEL = 69.3/85.2 mg/kg/day M/F

LOAEL = 560.1/656.2 mg/kg/day M/F, based
on coarse tremors in females from Weeks 6-17
and in gestation and lactation, decreased body
weight/weight gain and food consumption and
renal toxicity (tubular degeneration/
regeneration and increased weight) in males.





Offspring NOAEL = 69.3/85.2 mg/kg/day M/F

LOAEL = 317.6/355.2 mg/kg/day M/F, based
on clinical signs (perianal, urine or nasal
staining, diarrhea or soft stool, distended
abdomen, weakness, tremors, myoclonus,
increased activity and reactivity) and decreased
pup body weights throughout postnatal period.

Reproductive NOAEL = 69.3/85.2 mg/kg/day
M/F (based onFl intakes)

LOAEL = 317.6/355.2 mg/kg/day M/F, based
on delayed sexual maturation in males and
females (% pups reaching criterion unaffected).





93.14-94.5% a.i.



870.4100a

Chronic toxicity
(rat)

47443296 (2007)
Acceptable/Guideline
0, 300, 3000 or 10,000
ppm in the diet (6000 in
females after Day 280)
equivalent to average
daily intake of
M: 0, 14, 136 or 474
mg/kg/day;
F: 0, 19, 185 or 589
mg/kg/day
93.14% a.i.

NOAEL =19 mg/kg/day F, 136 mg/kg/day M;
LOAEL =185 mg/kg/day F, based on increased
mortality, clinical signs of toxicity, mydriasis
and absence of papillary reflex; 474 mg/kg/day
M, based on decreased body weight/weight
gain and food consumption.

870.4100b

Chronic toxicity
(dog)

47443294 (2008; main
study);47443295 (2007;
dietary stability)

NOAEL =2.0 mg/kg/day
LOAEL = 6/7 mg/kg/day M/F, based on axonal
degeneration of nerve fibers in the brain, spinal
cord and sciatic nerve in males and females.

6

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Type

MR ID No. (year)/
Classification /Doses

Results





Acceptable/Guideline

0, 60, 225 or 450 ppm in
the diet

M: 0,2, 6 or 12
mg/kg/day;

F: 0,2, 7 or 11
mg/kg/day

93.16% a.i.

Marginal body weight decreases early in study
seen at 12/11 mg/kg/day M/F.

870.4200a

Carcinogenicity
(rat)

See 870.4300, below

870.4200b

Carcinogenicity
(mouse)

47743416 (2008)

Acceptable/Guideline

0, 50, 250 or 1000 ppm in
diet

M: 0, 6.8, 34 or 142
mg/kg/day;

F: 0, 8.4, 42 or 168
mg/kg/day

93.14% a.i.

NO A F.I. = 34/42 mg/kg/day M/F
LOAEL = 142/168 mg/kg/day M/F, based on
decreased body weight/weight gain and food
consumption, M/F; renal and hepatotoxicity in
males; stomach and ovarian toxicity in females.

No evidence of carcinogenicity

870.4300

Combined
carcinogenicity/
chronic toxicity
(rat)

47743417 (2009)

Acceptable/Guideline

0, 300, 3000 or 10,000
ppm in the diet

M: 0, 12, 118 or 414

mg/kg/day;

F: 0, 17, 167 or 452
mg/kg/day

93.14% a.i.

NO A F.I. = 12/17 mg/kg/day M/F
LOAEL = 118/167 mg/kg/day M/F, based on
decreased body weight/weight gain, signs of
neurotoxicity (various symptoms, including
dilated pupils, tremors, limb/movement effects,
reduced activity/alertness) and renal toxicity in
females, liver toxicity in males and females and
atrophic seminal vesicles and increased TSH
(Week 3 only) and thyroid colloid alteration in
males. Thyroid alterations in males appeared to
be secondary to liver effects. Decreased
survival was observed at 452 mg/kg/day in
females and both males and females showed
more pronounced clinical signs of toxicity.

No evidence of carcinogenicity

Gene

Mutation

870.5100

Bacterial reverse
gene mutation
assay (S.
typhimurium)

47443297 (2006)

Acceptable/Guideline

0, 16, 50, 158, 500, 1581
or 5000 ng/plate in
presence or absence of S9
activation. Trial 1 - plate
incorporation method and
Trial 2, pre-incubation
method

90.32% a.i.

Negative +/-S9 activation in S. typhimurium
strains TA98, TA100, TA 102, TA1535,
TA1537 for increased frequency of revertant
colonies up to cytotoxic (500 |ig/plate) and
precipitating concentrations (5000 |ig/plate).

7

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Sludv Type

MR ID No. (year)/
Classification /Doses

Results

Gene
Mutation

870.5100

Bacterial reverse
gene mutation
assay (S.
typhimurium)

47443301 (2007)

Acceptable/Guideline

Trial 1: 0, 15, 50, 158,
500, 1502 or 5000
Hg/plate in the presence or
absence of S9 activation,
plate-incorporation
method

Trial 2: 0, 100, 200, 400,
800, 1600 or 3200
Hg/plate in the presence or
absence of S9 activation,
pre-incubation method

95.7% a.i.

Negative +/-S9 activation in S. typhimurium
strains TA98, TA100, TA102, TA1535,
TA1537 for increased frequency of revertant
colonies up to cytotoxic (>800 |ig/plate) and
precipitating (3200 |ig/plate) concentrations.

Gene

Mutation

870.5300

Mammalian cell
in vitro forward
gene mutation
(cultured V79
cells, HGPRT
locus)

47443302 (2006)

Acceptable/Guideline

0, 10, 100 or 1000 ng/mL
in presence or absence of
S9 activation

90.32% a.i.

Negative for increased frequency of mutation
in CHO cells (not cytotoxic).

Cytogenetics
870.5375

Mammalian in
vitro cytogenetic
assay (Chinese
hamster V79 lung
cells)

47443305 (2006)

Acceptable/Guideline

4 hr exposure, 14 hr
recovery period: 0, 15,
30, 60, 90 or 120 ng/mL
in the absence of S9
activation; 0, 50, 100,
160, 200 and 240 ng/mL
in the presence of S9
activation.

4 hr exposure, 26 hr
recovery period: 0, 60, 90
and 120 in the absence of
S9 activation; 0, 160, 200
and 240 ng/mL

18 hr exposure, no
recovery period in the
absence of S9 activation:
0, 4, 8, 16, 20 and 24
Hg/mL
90.32% a.i.

Negative for induction of chromosomal
aberrations above background in the presence
or absence of S9 metabolic activation. Tested
up to the limit of solubility (160 ng/mL, -S9)

Cytogenetics
870.5395

Mammalian in
vivo micronucleus
assay (mouse)

47443308 (2006)
Acceptable/Guideline
Two doses of 0, 10, 20 or

Negative for induction of increased frequency
of micronucleated polychromatic erythrocytes
in bone marrow at any treatment time.

8

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Tvpc

MR ID No. (year)/
Classification /Doses

Results





40 mg/kg by IP injection
in 0.5% aqueous
Cremaphor vehicle
administered 24 hrs apart;
harvested 24 hrs after
second dose

90.32% a.i.



870.6200a

Acute

neurotoxicity
screening battery
(rat)

47443310 (2008)

Acceptable/Guideline

0, 50, 100 or 2000 mg/kg
by gavage in corn oil.
Time of peak effect
estimated at 50 min
postdosing.

93.14% a.i.

NOAEL = 50 mg/kg

LOAEL = 100 mg/kg based on decreased
motor and locomotor activity in females
(threshold effect level). Lower
NOAEL/LOAEL relative to subchronic study
likely due to gavage vs. dietary administration.

870.6200b

Subchronic
neurotoxicity
screening battery
(rat)

47443309 (2008)

Acceptable/Guideline

0, 200, 4000 or
8000/10,000 ppm (M/F)
equivalent to average
daily intake in the diet of

M: 0, 12.2, 243.6 or
585.7 mg/kg/day

F: 0, 15.1, 306.9 or 580.9
mg/kg/day

93.14% a.i.

NOAEL = 243.6/306.9 mg/kg/day M/F

LOAEL = 585.7/580.9 mg/kg/day M/F, based
on decreased total session motor and locomotor
activity in females, clinical signs/FOB effects
in males and females (tremors, repetitive
chewing motion and perianal and lacrimal
staining), decreased body weights (females and
cumulative body weight gain in males and
females.

870.6300

Developmental
neurotoxicity (rat)

47443311 (2008)

Acceptable/Nonguideline

0, 150, 1000 or 7000 ppm
in the diet (high dose
reduced to 4000 ppm on
LD4) equivalent to
average daily intake in the
diet of

0, 13, 83.8 or 432
mg/kg/day

93.14% a.i.

Maternal NOAEL = 83.8 mg/kg/day

LOAEL = 432 mg/kg/day, based on clinical
signs at daily observation and FOB assessment
(coarse tremors, dilated pupils and dilated
pupils unresponsive to penlight, nasal staining,
repetitive chewing movements), decreased
body weights/weight gain and reduced number
of litters (-17%).

Offspring NOAEL = 83.8 mg/kg/day

LOAEL = 432 mg/kg/day, based on decreased
body weight through PND 21 in males and
females. Males postweaning had slightly
decreased body weights. Decreased motor
activity (-29%) on PND 21 in males was
considered treatment-related, but was not seen
at other measurement times nor in females.

870.7485

Metabolism and
pharmacokinetics

47443312 (2008)
Acceptable/Guideline

Absorption was complete (>90%
bioavailability) and rapid, with radioactivity

9

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Tvpc

MR ID No. (year)/
Classification /Doses

Results



(rat) - tier 1

Male rats given single
gavage dose of either 14C-
indane labeled or -triazine
labeled indaziflam at
11.5-14.98 mg/kg. Mass
balance groups - excreta
collected for 3 days
postdosing. Bile-duct
cannulated groups - bile
and excreta collected for 2
days postdosing.

99-100% radiochemical
purity

found in bile by 1 hr postdosing and most
radioactivity (generally around 90%) excreted
by 24 hrs. Tissue levels of radioactivity were
low (0.2% of administered dose by 3 days) with
highest levels observed in the GIT, liver,
kidney, skin and thyroid. In the bile duct-
cannulated animals, tissue levels were about 2-
4 times greater in the triazine-labeled group
than the indane-labeled group but levels in
other groups were similar. Excretion was
largely fecal (62-70%), with significant biliary
excretion observed. C02 exhalation was
negligible. Parent compound was identified at
between 2-16% of dose in urine and feces.
Major routes of metabolism were oxidative
pathways; glucuronide conjugation also
observed. Major metabolite was carboxylic
acid, found in urine, bile and feces. Numerous
other metabolites identified or characterized;
profile varied among dose groups. Other
metabolites identified at low levels included the
3-hydroxyindane acid epimer, diaminotriazine
and 3-ketohydroxymethyl metabolites.

870.7485

Metabolism and
pharmacokinetics
(rat) - tier 2

47743418 (2009)

Acceptable/Guideline

Single gavage doses as
follows: (1) low dose
mass balance studies in
females given 14C-indane-
labelled indaziflam at 4.8
mg/kg or 14-triazine-
labelled indaziflam at 8.8
mg/kg; (2) high dose mass
balance studies in males
given 14C-indane-labelled
indaziflam at 559 mg/kg
or 14-triazine-labelled
indaziflam at 723 mg/kg;
(3) plasma
pharmacokinetic
experiments with indane-
label at 2.9 mg/kg
(females) or 13.7 mg/kg
(males) or triazine-label at

13.2	mg/kg (females) or

16.3	mg/kg (males).

Radiochemical purity

99%

Absorption was rapid (radioactivity detected in
blood by 5 minutes and peak blood
concentrations observed between 40-60-
minutes postdosing; rapidly decreasing
thereafter) Females showed slightly higher
absorption than males. Excretion was rapid
(>87% by 24 hrs) and was equally distributed
between urine and feces in females but was
greater in feces in males (10:1). C02 excretion
was negligible. Radioactivity was not retained
at significant levels in tissues; the GIT, liver
and skin showed the highest residues. The
carboxylic acid metabolite was the major
metabolite in both high dose males and low
dose females, which was found in urine and
feces. Additional metabolites present at >5%
of dose included 3-hydroxyindane acid
metabolite in low dose females, dihydroxy
metabolite in low dose females and
hydroxyethyl acid metabolite in the high dose
males (indane-label).

870.7600

Dermal

47743420 (2008)

Absorption was inversely proportional to dose,

10

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Subchronic, Chronic, and Other Toxicity Profile for Indaziflam

Guideline
No.

Study Type

MR ID No. (year)/
Classification /Doses

Results

absorption, in vivo
(rat)

Acceptable/Guideline

0.5, 2 or 5000 ng ai/ cm2
on 12 cm2 skin for 8 hrs to
male rats; absorption
evaluated after 8, 24, 72
and 168 hr postdosing

Radiochemical purity

>98%

indicating saturation of skin penetration with
increasing dose. Between 0.4-20.4% of the
applied dose was recovered in combined
residual carcass, excreta, blood and non-treated
skin. Based on decreased radioactivity at the
application site, the most conservative value for
risk assessment is a dermal absorption of 42.7%
observed at 0.5 jig ai/ cm2 at 8 hr
postapplication.

870.7800

Immunotoxicity -
rat

47443313 (2008)

Acceptable/Guideline

0, 300, 3000 or 6000
(females) or 10,000/6000
(males) ppm in the diet
equivalent to average
daily intake in the diet of

M: 0,27.7, 258 or 528
mg/kg/day

F; 0, 31, 334.2 or 737.9
mg/kg/day

93.12% a.i.

Systemic NOAEL = 258.8/334.2 mg/kg/day
M/F

LOAEL = 528/737.9 mg/kg/day M/F, based on
mortality (one male sacrificed in extremis),
clinical signs of toxicity in males and females
(including tremor, abnormal gait, pallor,
hunched back), decreased food and water
consumption in males and decreased body
weight/weight gain in males and females.

Immunotoxicity NOAEL = 528/737.9
mg/kg/day M/F

LOAEL = not established (>528/737.9
mg/kg/day M/F)

Non-
guideline

In vitro dermal
absorption - rat
and human skin

47743419 (2007)

Acceptable/Nonguideline

Application of a 10j.iL/
volume of concentrated
500 mg/mL formulation
and representative spray
dilutions of 0.5, 0.2 or 1.0
mg/mL to excised human
and rat dermatomed skin.
Exposure duration was 24
hr.

Radiochemical purity

>98%

Total absorbed dose decreased with increasing
concentration, indicating saturation of skin
penetration with increasing dose. Rat skin was
3.8 to 10.7 times more permeable than human
skin over 24 hr at the concentrations tested.

A. Toxicological End Points and Doses Used in the Human Health Risk Assessment

The observed neurotoxic effects in rats and dogs serve as the basis for the risk assessment, since
all endpoints were associated with the neurotoxic effects observed in the animal studies. The
proposed use pattern is expected to result in dermal, inhalation and incidental oral exposures of
short- and intermediate-term durations; therefore, long-term exposure and risk were not assessed

-------
1.	Acute: EPA established an acute reference dose (aRfD) and an Acute Population Adjusted
Dose (aPAD) for indaziflam of 0.50 mg/kg body wt, based on the NOAEL of 50 mg/kg body
weight from the acute neurotoxicity study in rats and an uncertainty factor of 100. In this study,
decreased motor and locomotor activity was observed in females at the "lowest observed adverse
effect level" (LOAEL) of 100 mg/kg body wt.

2.	Chronic Dietary: EPA established a chronic reference dose (cRfD) and a Chronic Population
Adjusted Dose (cPAD) for indaziflam of 0.02 mg/kg body wt/day, based on the NOAEL of 2.0
mg/kg body wt/day from the chronic toxicity study in dogs and an uncertainty factor of 100. In
this study, nerve fiber degeneration in the brain, spinal cord and sciatic nerve was observed at the
LOAEL of 6/7 (M/F) mg/kg body wt/day.

3.	Short- and Intermediate-Term Incidental Oral Dermal and Inhalation: The same endpoint
(toxic effect) and dose (NOAEL) were selected for assessing incidental oral, dermal and
inhalation exposure. EPA selected the NOAEL of 7.5 mg/kg body wt/day from the subchronic
toxicity study in dogs based on brain, spinal cord and sciatic nerve degenerative lesions observed
at the LOAEL of 15 mg/kg body wt/day. Since the dermal and inhalation endpoints were
selected from an oral study, a dermal absorption factor of 7.3% and an inhalation absorption
factor of 100% were used in the relevant exposure assessments.

For all of these routes of exposure, EPA's Level of Concern (LOC) is a Margin of Exposure
(MOE; calculated as the NOAEL exposure) of 100; the LOC is based on the uncertainty factor
of 100, and MOEs less than 100 represent a potential risk concern.

4.	Cancer: EPA has classified indaziflam as "Not Likely to be Carcinogenic to Humans" based
on the lack of treatment-related tumors in the two-year rat and mouse bioassays and no concerns
for mutagenicity.

A summary of the toxicological endpoints are shown in the table below:

Summary of Toxicologica
Occupational Human Hea

I Doses and Endpoints for Indaziflam for Use in Dietary and Non-
th Risk Assessments

Exposure/
Scenario

Point of
Departure

Uncertainty/FQPA
Safely Factors

RID. PAD.

Level of
Concern for

Risk
Assessment

Study and Toxicological Effects

Acute Dietary
(All

Populations,
including
Infants and
Children and
Females 13-49
years of age)

NOAEL=
50

mg/kg/day

UFa= 10X
UFh= 10X
FQPA SF= IX

Acute RfD =
0.5

mg/kg/day

aPAD = 0.5
mg/kg/day

Acute oral neurotoxicity in the rat
LOAEL =100 mg/kg/day, based on
decreased motor and locomotor activity in
females.

12

-------
Summary of Toxicologica
Occupational Human Hea

I Doses and Endpoints for Indaziflam for Use in Dietary and Non-
th Risk Assessments

Exposure/
Scenario

Point of
Departure

U nccrlai nly/FQPA
Safety Factors

RID. PAD.

Level of
Concern for

Risk
Assessment

Study and Toxicological Effects

Chronic
Dietary (All
Populations)

NOAEL = 2
mg/kg/day

UFa= 10X
UFh= 10X
FQPA SF= IX

Chronic RfD =
0.02

mg/kg/day

cPAD = 0.02
mg/kg/day

Chronic oral (dietary) toxicity in the dog
LOAEL = 6/7 mg/kg/day M/F, based on
nerve fiber degenerative lesions in the
brain, spinal cord and sciatic nerve.

Incidental
Oral, Short-
term (1 to 30
days) and
Intermediate-
term (1 to 6
months)

NOAEL=
7.5

mg/kg/day

UFa=10X

ufh=iox

FQPA SF = IX

Residential
LOC for MOE
= 100

Subchronic oral (gavage) in the dog
LOAEL =15 mg/kg/day, based on axonal
degenerative microscopic findings in the
brain, spinal cord and sciatic nerve.

Dermal, Short-
term (1 to 30
days) and
Intermediate-
term (1 to 6
months)

NOAEL=
7.5

mg/kg/day
DAF =
7.3%

UFa=10X

ufh=iox

FQPA SF = IX

Residential
LOC for MOE
= 100

Subchronic oral (gavage) in the dog
LOAEL =15 mg/kg/day, based on axonal
degenerative microscopic findings in the
brain, spinal cord and sciatic nerve.

Dermal, Long-
Term (>6
months)

Not required for this assessment (exposure is seasonal; long-term occupational exposure scenarios
are not anticipated).

Inhalation,
Short-term (1
to 30 days)
and

Intermediate-
term (1 to 6
months)

NOAEL=
7.5

mg/kg/day
Inhalation
absorption
assumed to
be 100%
(default)
relative to
oral.

UFa=10X

ufh=iox

FQPA SF = IX

Residential
LOC for MOE
= 100

Subchronic oral (gavage) in the dog
LOAEL =15 mg/kg/day, based on axonal
degenerative microscopic findings in the
brain, spinal cord and sciatic nerve.

Inhalation,
Long-term (>6
months)

Not required for this assessment (exposure is seasonal; long-term occupational exposure scenarios
are not anticipated).

Cancer (oral,

dermal,

inhalation)

Classification: "Not likely to be Carcinogenic to Humans"

Summary of Toxicological Doses and Endpoints for Indaziflam for Use in Occupational Human
Health Risk Assessments

Exposure/
Scenario

Point of
Departure

Uncertainty
Factors

Level of Concern
for Risk
Assessment

Study and Toxicological Effects

13

-------
Summary of Toxicological Doses and Endpoints for Indaziflam for Use in Occupational Human
Health Risk Assessments

Exposure/
Scenario

Point of
Departure

Uncertainly
Factors

Level of Concern
for Risk
Assessment

Study and Toxicological Effects

Dermal, Short-
Term (1 to 30
days) and
Intermediate-
term (1 to 6
months)

NOAEL =
7.5

mg/kg/day
DAF = 7.3%

UFa=10X

ufh=iox

Occupational LOC
for MOE = 100

Subchronic oral (gavage) in the dog
LOAEL =15 mg/kg/day, based on axonal
degenerative microscopic findings in the
brain, spinal cord and sciatic nerve.

Dermal, Long-
Term (>6
months)

Not required for this assessment (exposure is seasonal; long-term occupational exposure scenarios
are not anticipated).



NOAEL=
7.5

mg/kg/day.
Inhalation
absorption
assumed to
be 100%
(default)
relative to
oral.







Inhalation
Short-Term (1
to 30 days) and
Intermediate-
Term (1 to 6
months)

UFa=10X

ufh=iox

Occupational LOC
for MOE = 100

Subchronic oral (gavage) in the dog
LOAEL =15 mg/kg/day, based on axonal
degenerative microscopic findings in the
brain, spinal cord and sciatic nerve.

Inhalation
Long-Term (>
6 months)

Not required for this assessment (exposure is seasonal; long-term occupational exposure scenarios
are not anticipated).

Cancer (oral,

dermal,

inhalation)

Classification

"Not likely to be Carcinogenic to Humans"

B. FQPA Safety Factor

Although there are no food uses associated with this decision, there are food uses pending
review, and, therefore, EPA evaluated the potential impact of the decision on infants and
children. The Agency determined that reliable data show that it would be safe to reduce the
FQPA safety factor for infants and children to IX based on the following findings:

•	The toxicity database for indaziflam is considered complete and includes acceptable
developmental toxicity studies in rats and rabbits, a two-generation reproductive toxicity
study in rats, a developmental neurotoxicity in rats, acute and subchronic neurotoxicity
screening studies in rats, and an immunotoxicity study.

•	Although indaziflam is a neurotoxic chemical, there is no evidence of increased
qualitative or quantitative susceptibility of offspring to neurotoxic effects in any of the
available studies, including a developmental neurotoxicity study. Therefore, an
additional uncertainty factor to account for neurotoxicity is unnecessary.

•	There is no evidence that indaziflam results in increased pre- or postnatal susceptibility of
rats or rabbits in the prenatal developmental studies or of rats in the 2-generation
reproduction study. Effects on fetuses and offspring in these studies were observed at
doses that also resulted in parental toxicity. The endpoints selected for risk assessment

14

-------
are protective of potential developmental effects.

• There are no residual uncertainties identified in the exposure databases. EPA made
conservative (protective) assumptions in the ground and surface water modeling used to
assess exposure to indaziflam in drinking water. EPA used similarly conservative
assumptions to assess post-application exposure of children including incidental oral
exposure of toddlers. These assessments will not underestimate the exposure and risks
posed by indaziflam.

C. Cumulative Effects

Indaziflam and its metabolite fluoroethyldiaminotriazine (FDAT) contain a triazine moiety
within their chemical structures. Several triazine herbicides were determined by EPA to have a
common mechanism of toxicity based on their ability to disrupt the hypothalamic-pituitary-
gonadal axis (US EPA, 2002). The triazine common mechanism group (TCMG) includes
atrazine, simazine, propazine, and the metabolites desethyl-s-atrazine (DEA), deisopropyl-s-
atrazine (DIA), and diaminochlorotriazine (DACT). Indaziflam and its metabolite FDAT were
considered for incorporation into the TCMG by EPA based on structure; indaziflam, FDAT, and
the TCMG members contain a common triazine moiety. However, EPA determined that it
would not be appropriate to include indaziflam and FDAT in the TCMG for the following
reasons: 1) The structure of indaziflam and FDAT are unique in that they contain a fluoroethyl
group at the 2-position of the triazine ring, whereas the TCMG members contain a chlorine
substituent at the 2-position of the triazine ring and; 2) Indaziflam and FDAT do not elicit the
same toxicological responses shared by the TCMG members. The TCMG members cause an
increase in mammary gland tumors in rats and multiple developmental effects such as
attenuation of the luteinizing hormone surge, altered pregnancy outcome, and delayed preputial
separation. Although delayed sexual maturation was observed in the rat reproductive toxicity
study, the effects occurred only at the highest dose. None of the other effects associated with the
TCMG members were observed in the carcinogenicity, developmental, or reproductive guideline
studies for indaziflam. In a non-guideline study, FDAT delayed vaginal patency in a dose-
dependent manner. However, none of the other characteristic developmental effects of the
TCMG members were observed, and this effect only occurred at higher doses compared to
DACT.

Therefore, unlike other pesticides for which EPA has followed a cumulative risk approach based
on a common mechanism of toxicity, EPA has not made a common mechanism of toxicity
finding for indaziflam or its metabolite FDAT and any other substances, and indaziflam does not
appear to produce a toxic metabolite produced by other substances. Therefore, for the purposes
of this risk assessment, EPA has not assumed that indaziflam or its metabolite FDAT has a
common mechanism of toxicity with other substances.

D. Aggregate Risk Assessment

1. Drinking Water Risk:

A screening level drinking water exposure risk assessment was conducted using the Dietary
Exposure Evaluation Model Database (DEEM-FCID ™) and estimated drinking water

-------
concentrations (EDWCs) generated using the Pesticide Root Zone Model /Exposure Analysis
Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-
GROW) model.

Acute and chronic drinking water risk estimates are not of concern. Dietary exposure to
indaziflam from drinking water will occupy 3.0% of the aPAD and 9.0% of the cPAD for
infants, less than 1 year old, the population subgroup with the highest estimated exposure to
indaziflam.

2. Residential Risk:

There is a potential for exposure of homeowners applying products containing indaziflam on
home lawns. There is also a potential for post-application exposure of adults and children
entering lawn and recreation areas, including golf courses, which have been treated with
indaziflam. Indaziflam post-application inhalation exposures are expected to be negligible due
to its low vapor pressure, low application rates, and the types of application equipment used (i.e.,
hand-held equipment that is not likely to generate a vapor). Therefore, a quantitative post-
application inhalation exposure assessment was not considered necessary. This conclusion may
change in the future if new policies for inhalation exposure and risk assessment are developed.
EPA assessed the following residential exposure scenarios:

• short -term dermal and inhalation exposures of residential handlers using various types of
application equipment and formulation types on the proposed residential use sites;

• short -term post-application dermal exposures of adults and children entering treated turf
areas; and

• short-term postapplication incidental oral exposures of children from contact with treated
turfgrass.

Since the doses and endpoints selected to assess short- and intermediate-term exposures are the
same, a quantitative intermediate-term assessment was not completed; however, the short-term
risk assessments are protective of intermediate-term risks. For residential and occupational
exposure, the Agency uses the term Margin of Exposure (MOE) to refer to the risk associated
with the exposure estimate. The MOE is defined as the dose, usually the No Observed Adverse
Effects Level (NOAEL), divided by the estimated human exposure. An MOE of 100 means that
the estimated level of human exposure is 100 times lower than the highest dose that produced no
adverse effects in the relevant toxicology study. The greater the MOE, the lower the risk. An
MOE of 100 or greater indicates there are no risks of concern.

Estimated short -term residential handler MOEs (combined dermal and inhalation exposures)
range from 3,000 to 510,000. Estimated MOEs for short-term post-application dermal exposures
of adults entering treated lawn areas range from 4,700 to 10,000. The estimated MOE for golfers
playing on treated turf is 90,000. The estimated combined MOE for short-term postapplication
exposures of children (including dermal and incidental oral exposures) is 1,800. Since all
estimated MOEs are well above 100, they are not of concern.

-------
Residential 1 l;i ik) lei 1

\posnre anil Risk















lull

I se Sue

Dermal

Inlialali

\pplica

\rea

Dermal

Dermal

Inlialali



lolal

1 Aposlll'



1 mi

on 1 nil

lion

1 real

1 )ose

\ioi:

Oil

Inhalal

\ioi:

c



1 \posn

1 Aposll

kale

eil

i iiiu ku



1 )ose

IOIl\1( )



Scenario



IV

IV

ilh

( \ il

das i



i nm ku

i:



s



mm Ihi

i mu lb

ai acre)

a> i





ila> i





\li\er Loader \p

ilicalor

1. Hose-

lawns,



















end

hardscap

11

0.017

0.094



0.00053

14,000

1.14E-5

660,000

14,00

Sprayer

es and







0.5

9







0

"Mix

ornamen



















Your

tals



















Own"





















2. Belly



110

0.062

0.044



0.00252

3000

1.95E-5

380,000

3000

Grinder





























0.02

3

0.00011

68,000

8.96E-7

8,000,00
0

67,00
0

3. Hand-





















Held



56

0.0038

0.

5

0.00018

41,000

1.71E-7

44,000,0

40,00

Pump







00063

gallo

4





00

0

Sprayer









ns











Applicator

4.

Trigger



54

0.0019



1

0.00001

510,000

7.0E-9

100,000,

510,0

sprayer







0.0002

gallo

4





000

00

Ready
to Use







6

lbai/gal

n











5.

lawns



















Granular



0.67

0.0008

0.044



0.00001

490,000

2.77e-7

27,000,0

480,0

Push





8





54





00

00

Spreader





















6. Hose

lawns,







0.5











End

hardscap

11

0.011

0. 094



0.00012

59,000

7.39E-6

1,000,00

56,00

Sprayer

es and









7





0

0

Ready

ornamen



















to Use

tals



















a.	Application Rate based on proposed labels

b.	Dermal Dose = Unit Exposure (mg/lb) x Application Rate (lb ai/acre or lb ai/gal. ) x Area Treated (acre/day or gal./day) x
7.3% dermal absorption factor/BW

c.	Dermal MOE = NOAEL (7.5 mg/kg/day)/Dermal Dose (mg/kg/day)

d.	Inhalation Dose = Unit Exposure (mg/lb) x Application Rate (lb ai/acre or lb ai/gal. ) x Area Treated (acre/day or
gal./day )/BW

e.	Inhalation MOE = NOAEL (7.5 mg/kg/day)/Inhalation Dose (mg/kg/day)

g. Total MOE = NOAEL (7.5 mg/kg/day)/ (dermal dose + inhalation dose) mg/kg/day

17

-------
Kislapplicalion SIkhi-ici'iii Dermal 1 \piiMiic and Risk

Scenario

\pplicalioii kale

Ilk

(t

Slkiri-Term

IT

WW



1 )ose

\ioi:



(lb;ii \)

(jiu cm i



Ic

(Ill's)

(km



( iiiu ku das i











(cm lin











\dulis

1 lose-end

0.094

0.05264

0.001

14500 -

2

70



0.001592

4,700

Sprayer

(ornamentals &





lawn













lawn)



















0.047

0.02632











0.000796

9,400



(lawn)



















0.071 *

0.03976











0.0012

6,000

Hand-held

0.094

0.05264











0.001592

4,700

Pump Sprayer

(ornamentals &



















lawn)

















Belly Grinder

0.044

0.02464











0.000745

10,000

& Granular



















Push Spreader

0.071

0.03976











0.0012

6,000

Golfer

Hose-end

0.071 *

0.03976

0.001

500

4

70

0.0000829

90,000

Sprayer or



















Granular Push



















Spreader























Children (."

to 6 vears)











Hose-end

0.094

0.05264

0.001

5200 - lawn

2

15

0.00266

2,800

Sprayer





















0.047

0.02632









0.0013

5,800



0.071 *

0.03976









0.0020

3,700

Hand-held

0.094

0.05264









0.00266

2,800

Pump Sprayer



















Belly Grinder



















& Granular

0.044

0.02464









0.001247

6,000

Push Spreader





















0.071 *

0.03976









0.0020

3,700

1.	Turf Transferable Residues (TTR) = Application Rate x 0.05% x 11.2

2.	Dermal Dose (mg/kg/day) = TTR rug/cm2-! x 0.001 (nig/tig-! x short-term TC ("cmVhrlxET fhr/dav'l x DAF (7.3%)

BW (kg)

3. Short-term Dermal MOE = NOAEL (7.5 mg/kg/day )/Dermal Dose (mg/kg/day)
* = commercially applied

1 land-Ti»-\1i»uih 1 Aposiiic and kisk lor Children (' io<>\eaiM

hoducl

Ilk

dm cm i

S.\

(cm cnciiI)

in

si:

IT

(lir das i

(T

13\V
(km

1 )iisc

( iiiu ku da\ i

\ioi:

Slkn'1-icmi

BCS AA10717
Turf Fertilizer
(432-RUOL; 432-
RUOA; and 432-
RUOT) and 20

3.98E-2

20

20

0.5

2

0.001

15

1.06E-3

7,000

18

-------
1 land-1 'i»-\1i»uih 1 AiiosiNc and Risk lor Children (^ Ii<(>\c;hm

hnducl

Ilk

um cm )

S.\

(cm c\cnli

l-O

si:

i:t

(lir das i

CI"

li\\
(km

1 )osc

( iiiu ku das i

\ioi:

SlKH'i-ierm

WSP (432-RUOO)



















Lawn 3FL
(72155-10)

5.27E-2

1.41E-3

5,300

1.	Turf Transferable Residues = (TTR) =

AR (0.071 or 0.094 lb ai/A) x F (0.05) x (1-D)° x CF2 (4.54E8 ng/lb) x CF3 (2.47E-8 acre /cm2) = 03.98E-2 or 5.27E-2 ug/cm2

2.	Dose = TTRtxSAxFOxETxSExCFl

BW

3. MOE = NOAEL (7.5 mg/kg/day)/HTM Dose (mg/kg/day)

()h|ccl U)-\K>ulli 1 \posiirc and Risk I'oi' ( lnldrcii ( ' u» <> \carsi

hnducl

(iR

dm cm i

CF

(IIIU II u)

luR

(cm da> i

li\\

(kg)

Dose

( iiiu ku da\ i

\ioi:

BCS AA10717 Turf Fertilizer
(432-RUOL; 432-RUOA; and
432-RUOT) and
20 WSP (432-RUOO)

1.59E-1

0.001

25

15

2.65E-4

28,000

Lawn 3FL
(72155-10)

2.11E-1

0.001

25

15

3.51E-4

21,000

1.	GR (grass residue) = AR x F x (1-D)° x CF2 x CF3

2.	Dose = GR0xIgRxCFl

3.	MOE = NOAEL (7.5 mg/kg/day)/Dose (mg/kg/day)

Still limcsikHi 1 Aposmc and Risk Risk fur Children (' in <> \ cars)

Rrndiicl

SR

dm m

Cl;

(U IIu)

luR

( iiiu da> i

13\V

(kg)

Dose"

( iiiu ku da\ i

\ioi:

BCS AA10717 Turf Fertilizer
(432-RUOL; 432-RUOA; and
432-RUOT) and
20 WSP (432-RUOO)

5.33E-1

0.000001

25

15

3.56E-6

2.11E6

Lawn 3FL
(72155-10)

7.06E-1

0.000001

25

15

4.71E-6

1.59E6

1.	SR0 (soil residue) = AR(lb ai/A) x F(l) x (1-D)° x 0.67 x (4.54x10s ng/lg)x (2.47 x 10"8 A/cm2)

2.	Dose (mg/kg/day) = SR0 (ng/g) x IgR (mg/day) x CF1 (g/|ig)/BW (kg)

3.	MOE = NOAEL (7.5 mg/kg/day)/ Dose (mg/kg/day)

Poslapplicalion Exposure and Risk for Incidental Ingestion of Granules

Scenario

IgR
(g/day)

F

CF1
(mg/g)

Dose a
(mg/kg/day)

MOEb

Lawn 3FL Granule Reg No 72155-OR

0.3

0.0005

1000

0.001

5,000

a.	Dose = IgR x F x CF1 h- BW

b.	MOE = acute dietary NOAEL (50 mg/kg/day)/Dose

19

-------
Combined Residential 1 !\ix»miiv Risk

Product

I se Sue

Handler

Total

\ioi:

l\>sl-appl ical ion
Dermal \l()l!

1 laud-lo-\1ouih

\ioi:

Combined
\ioi:

\dult

Lawn 3FL Concentrate
/Ready to spray
72155-10

Lawns,
hardscapes

and
ornamentals

3,000

4,700

Child

Lawn 3 FL (72155-10)

Lawns,
hardscapes

and
ornamentals

2,800

5,300

1,800

1. See Indaziflam Residential Handler Exposure and Risk (Hand Held Pump)

2. See Dermal Postapplication Exposure and Risk (DFR data)

3. See Hand-To-Mouth Exposure and Risk

4. Adult Combined MOE = NA = HED does not combine adult handler and postapplication exposure

Child Combinded MOE = NOAEL (7.5 mg/kg/day)/dermal postapplication dose (0.00266) + HTM dose (1.41E-3)

3. Aggregate Risk:

In the absence of food uses, an aggregate risk assessment was not needed for indaziflam.
However, the screening-level combined exposures from drinking water and residential settings
result in estimated MOEs of 1,100 for children and 1,700 for adults. Therefore, combined
exposure and risk from drinking water and residential sources are not of concern.

Short-Term Combined Risk Calculations

Population

LOC for

Aggregate

Risk

MOE
drinking

water

MOE
Total
Handler

MOE
Dermal

Postapplication

MOE
Oral

Combined MOE
(drinking water +
residential)

US Population

100

3700

3,000

4,700

1700

Child (3-6 yrs)

100

2500

2,800

5,300

1100

E. Occupational Risk Assessment

Short- and intermediate-term occupational handler and postapplication exposures are possible
based on the proposed use pattern. However, since the same endpoint and dose were selected for
both short- and intermediate-term risk assessment, intermediate-term exposures were not
assessed. Short-term exposure and risk estimates are protective of corresponding intermediate-
term exposure and risk.

1. Handler Exposure and Risk:

EPA assessed short-term dermal and inhalation exposures of occupational handlers. Combined
inhalation/dermal MOEs for occupational handlers range from 100 to 840,000. Since all MOEs
are greater than or equal to 100, short -term risks for handlers are not of concern.

-------
( Jeeupalioiial 1 landler 1 Aposures ;n

id Risks





















\rea

Dermal

Inlialali

Dermal

Derm

1 nlialal i

1 nlialal i

Tula

I ¦ \posure

Tun <1

Appliea

1 real e

1 nil

kii 1 mi

1 )ose

al

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on

1

Scenario and

Slle

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1 Aposll

1 Apiisll

dim ku

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(nm 111»

IV

(nm Ibi

da> i



i nm ku
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i:

Mixer/Loader

Liquids for
Aerial

Applications
(PHED)
Esplanade F

forestr

y

0.1251b
ai/A

1200
A

0.023
single
layer/
gloves



0.0035
98

2100

0.00257
1

2900

1200

Liquids for
Ground

forestr

0.1251b

200 A



0.0012

0.0006

13,00

0.00042

10,000

7,30

Applications
(PHED)
Esplanade F

y

ai/A









0

9



0

Liquids for
Ground, and
Right-of-Way,
Applications
(PHED)
Esplanade
200SC

non-
crop
areas *

0.089 lb
ai/A

25 A

2.9



0.0067

3

1100

3.81E-5

196,000

1100



Non-



5 A





7.77E-6

960,0

1.22E-6

6,000,00

830,



crop
areas,

0.071 lb
ai/A



0.021

0.00024



00



0

000



turf

(non-



















grass,

crop)



















nursen





















es,





















landsca





















pes



















Water Soluble
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course

and

fields

grown

for



40 A





6.22E-5

120,0
00

9.74E-6

770,000

100,
000

Ground
Applications
(PHED)
BCS-AA10717



















20 WSP

ntals





















sod



80 A





0.0001

60,00

1.95E-5

390,000

52,0



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and,









24

0





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forestr

0.088 lb

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0.0003

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for Tractor
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(PHED)
BCS-AA10717
plus turf

onal
fields
and
parks

0.071 lb
ai/A

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3.11E-6

2,400,
000

8.62E-6

870,000

640,
000

golf



40 A





2.49E-5

300,0
00

6.9E-5

100,00

80,0
00

course	0

21

-------
( k.viip;ilkiii;il 1 landler 1 Apusnres ;n

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(0.0142%,
0.0213%, and
0.0284%)





















sod
farm



80 A





4.98E-5

150,0
00

0.0001
38

54,000

40,0
00

Applicators

Applying
Sprays via

Aerial
Equipment
(PHED)

forestr

y

0.1251b

ai/A
Esplana
de F

1200
A

0.005

Eng
controlf

0.00006
8

Eng
controlf

0.0007
8

9,600

0.0001
46

51,000

8,10
0





0.1251b

ai/A
Esplana
de F

200 A





0.0003
65

21,00
0

0.0002
64

28,000

12,0
00



forestr

y

0.088 lb
ai/A
BCS-
AA1071
7

20 WSP







0.0002
57

30,00
0

0.0001
86

40,000

17,0
00



non-
crop
areas *

0.089 lb

ai/A
Esplana

de
200SC

40 A

0.014



0.0000
52

140,0
00

3.76E-5

200,00
0

84,0
00

Applying
Sprays via
Groundboom
Equipment
(PHED)

Non-
crop
sites,
turf
and
recreati

on
fields

0.071 lb
ai/A
BCS-
AA1071

5 A



0.0007
4

0.0000
0518

1,400,
000

3.75E-6

2,000,0
00

840,
000



Golf
course
and
field
grown

for
orname
ntals
and
nurseri
es

7

20 WSP

40 A





0.0000
415

180,0
00

3.0E-5

250,00
0

100,
000



Sod
and
Christ
mas
tree
farms,



80 A





0.0000
829

90,00
0

6.0E-5

120,00
0

52,0
00

Applying
Sprays via
Right-of-Way

non-
crop
areas *

0.089 lb

ai/A
Esplana

25 A



0.0039

0.0000
325

230,0
00

0.0001
24

60,000

48,0
00

22

-------
( )eeiipaliiiiial 1 landler 1 Aposnres ;iik.I Risks

I ¦ \posure
Scenario and
h'udnel

laruel

SIIC

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(PHED)



de
200SC

















Applying
Granules using
Solid
Broadcast
Spreader
(PHED)

Lawns,
turf,
sports
and
recreati

on
parks

0.071 lb
ai/A
BCS-
AA1071
7 plus
turf
fertilizer
(0.0142
%,
0.0213
%, and
0.0284
%)

5 A

0.0099

0.0063

0.0000
0367

2,000,
000

0.0000
32

230,00
0

210,
000

golf
courses

40 A

0.0000
293

260,0
00

0.0002
56

29,000

26,0
00

sod
farms

80 A

.00005
86

130,0
00

0.0005
1

15,000

13,0
00

LCO Push
Cyclone
Granular
Spreader
(OMAOOl)OR
ETF

Lawns,
turf,
sports
and
recreati

on
parks

0.071 lb
ai/A

5 A

0.35

0.0073

0.0001

3

56,00
0

0.0000
37

200,00
0

45,0
00

golf
courses

40 A

0.0010

7,200

0.0002
96

25,000

5,60
0

sod
farms

80 A

0.0020

3,600

0.0053
2

12,000

2,80
0

Belly Grinder
(PHED)

Lawns,
turf,
sports
and
recreati

on
parks

1 A

10

0.062

0.0007
4

10,00
0

6.29E-5

120,00
0

9,30
0

Flaggers

Flagging for
Aerial Sprays
Applications

(PHED)
Esplanade F

forestr

y

0.1251b
ai/A

350 A

0.011

0.0003
5

0.0005
0

15,00
0

0.0002
19

34,000

10,0
00

Mixer/Loader/Applicator

Mixing/Loadin
g/Applying
Liquids with
Low Pressure
Handwand
(PHED)

Forestr

y

Esplan
ade F

0.1251b
ai/A

5 A

100

0.03

0.0652

120

0.0002
68

28,000

110

0.0248
lb ai/gal

40 gals

0.43

0.0004
45

17,00
0

0.0004
25

18,000

8,60
0

non-
crop
areas *

0.089 lb
ai/A

5 A



0.0464

160



39,000

160

23

-------
( k.viip;ilkiii;il 1 landler 1 Apusnres ;n

id Risks





















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on

1

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100







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ade
200SC

0.0178
lb ai/gal

40 gals





0.0742
5

100

0.0003
05

25,000

100



Forestr

y

0.1251b
ai/A

5 A





0.0016

3

4600

0.0002
68

28,000

4,00
0

Mixing/Loadin
g/ Applying
Liquids with
Back Pack

Esplan
ade F

0.0248

40 gals

2.5



0.0025
8

3,000

0.0004
25

18,000

2,50
0

non-
crop

0.089 lb
ai/A

5 A





0.0011

6

6,500

0.0001
91

39,000

5,60
0

(PHED)

areas*
Esplan

ade
200SC

0.0178
lb ai/A

40 gals





0.0018
5

4,000

0.0003
05

25,000

3,50
0



Non-



















Mixing/Loadin
g/Applying

Liquid
Concentrates
with a
Handgun
Sprayer (LCO
ORETF)

crop
sites,
turf,
recreati

0.071
BCS-
A10717
20 WSP



0.64

0.0072

0.0002
37

32,00
0

0.0000
365

200,00
0

27,0
00

on
fields,
Christ
mas
tree
farms,
orname
ntals
and
nurseri
es

0.089
Esplana

de
200SC

5 A

0.45

0.0018

0.0002
09

36,00
0

0.0000
14E-5

650,00
0

34,0
00

***NOTE TABLE CONTAINS PRODUCTS AND USES WHICH ARE PENDING REGISTRATION WITH THE AGENCY***

a	Application rates = maximum application rates from labels.

b	Amount handled per day values are HED estimates of acres treated per day based on Exposure SAC SOP #9 "Standard Values for

Daily Acres Treated in Agriculture," industry sources, and HED estimates,
c	Dose (mg/kg/day) = Unit exposure(mg/lb ai) x App Rate (lb ai/acre) x Area Treated (acres/day) x %Absorption (7.3% dermal

and 100% inhalation) / Body weight (70 kg),
d	MOE = NOAEL (7.5 mg/kg/day) / Dose (mg/kg/day)

e	All scenarios were run at Baseline (dermal - single layer clothing; Inhalation - no respirator) unless otherwise specified.

f.	Eng Con: Engineering control is enclosed cab, or enclosed cockpit.

g.	Total MOE = NOAEL (7.5 mg/kg/day) / Dermal Dose + Inhalation Dose (mg/kg/day)

*non crop areas = rail road yards, roadsides, ornamental and perennial plantings, fence rows, utilities, hardscapes, industrial,
municipal and government site

2. Occupational Postapplication Exposure and Risk:

Occupational post-application dermal MOEs ranged from 1,400 to 45,000 and, therefore, are not
of concern. Post-application inhalation exposures to indaziflam are expected to be negligible due
to indaziflam's low vapor pressure and low application rates; in addition, with the exception of
forestry applications, the types of application equipment used will minimize the formation of a
vapor or fine aerosol that would lead to significant inhalation exposure. Although post-

24

-------
application inhalation exposure was not assessed quantitatively, this approach may change in the
future if new policies for inhalation exposure and risk assessment are developed.

Poslapplicalion Exposure and Risk for Inda/iflam

Scenario

Tc

(cm2/hr)

DAT1

DFR

2(ug/cm2)

DOSE3
(mg/kg/day)

MOE4

Sod farm & Golf
Course Mowing

500

0

0.016

0.000066

110,000

hand weeding &,
transplant of turf

16,500

0

0.002

3,400

Outdoor
ornamentals

110

0

0.159

0.000145

51,000

Moving
ornamentals in
pots to trucks
and reorganizing

400

0

0.001

14,000

Christmas Trees
thinning

3000

0

0.016

0.00040

19,000

1.	DAT = Days after treatment

2.	DFR = Dislodgeable Foliar Residue = application rate (0.071 lb ai/A) x (1- daily dissipation rate) t x 4.54E8 ug/lb x
24.7E-9 A/cm2 x % TTR (5% for turn and 2% for ornamentals) after initial treatment.

3.	Dermal Dose = [TTR (ug/cm2) x Tc (cm2/hr) x 0.001 mg/ug x 8 hrs/day x 7.3%DA] + body weight (70 kg)

4.	MOE = NOAEL (7.5 mg/kg/day)/Dermal Dose

V. ENVIRONMENTAL RISK

A summary of the environmental fate and ecological effects and risks of indaziflam as assessed
in the Agency document titled "Environmental Fate and Ecological Risk Assessment for the
Registration of Indaziflam" is provided below.

A. Environmental Fate

Indaziflam is expected to be moderately mobile to mobile in the soil (Koc < 1000 mL/g oc),
moderately persistent to persistent in aerobic soil (half-lives >150 days), persistent in anaerobic
soil (stable), and persistent in aerobic (half-lives > 200 days) and anaerobic (stable) aquatic
environments. Indaziflam is subject to aqueous photolysis in clear shallow waters (half-life < 5
days). Indaziflam is not volatile and therefore, is not likely to be transported via atmospheric
processes following application. It is a weak acid and is moderately soluble at environmental pH
values. Indaziflam dissipates in the environment primarily through biotic degradation and
leaching. Indaziflam degradates are more mobile than the parent (Koc <100 mL/g oc), and were
detected in field studies at the deepest depths sampled (105-120 cm). The degradate FDAT is
mobile to highly mobile (Koc ranged from 10-50 mL/g oc) and has the potential to leach to the
ground water.

25

-------
The major transformation products resulting from the environmental degradation of indaziflam
are: triazine-indanone; indaziflam-carboxylic acid; indaziflam-hydroxyethyl; indaziflam-olefin;
fluoroethyldiaminotriazine; and fluoroethyltriazinanedione. The toxicity data show that
indaziflam-olefin and indaziflam-hydroxyethyl are of similar toxicity to the TGAI, based on the
most sensitive taxa tested, while indaziflam-hydroxyethyl, FDAT, and triazine indanone
demonstrate toxicities at magnitudes 2-7 times less than that of the parent. Aquatic exposure
estimates are based on a total toxic residue approach of indaziflam + residues of concern (two
major photodegradates: indaziflam-olefin and indaziflam-hydroxyethyl). Terrestrial exposure
estimates are based on the residue levels of indaziflam alone. Data are not generally available
for screening level assessments to assess the terrestrial exposure and effects of degradates, as is
the case for the assessment of indaziflam. The conservative 35-day foliar dissipation half-life
used in the terrestrial modeling may account for the formation and toxicity of the degradates
(assuming the degradates are not any more toxic than the parent). Any effects of the degradates
to terrestrial plants that might occur over a 21 day time period would be captured by the nature of
the terrestrial plant studies conducted on indaziflam's formulated products. Bioaccumulation is
not expected for indaziflam.

To address concerns with the potential leaching of indaziflam that may result from the
persistence and mobility described above, labels will be required to have language including
surface and ground water advisories that stress the potential of runoff after treatment and
descriptions of conditions that may promote leaching to groundwater.

B. Ecological Risk

Ecological risk characterization integrates the results of the exposure and ecotoxicity data to
evaluate the likelihood of adverse ecological effects. The means of integrating the results of
exposure and ecotoxicity data is called the quotient method. For this method, risk quotients
(RQs) are calculated by dividing exposure estimates by ecotoxicity values, both acute and
chronic (RQ = Exposure/Toxicity). RQs are then compared to EPA's levels of concern (LOCs).
The LOCs are criteria used by the Agency to indicate potential risk to nontarget organisms. The
criteria indicate whether a pesticide, when used as directed, has the potential to cause adverse
effects to nontarget organisms.

The ecotoxicity endpoints derived from the results of short-term laboratory studies that assess
acute effects are: (1) LC50 (fish and birds); (2) LD50 (birds and mammals); (3) EC50 (aquatic
plants and aquatic invertebrates) and; (4) EC25 (terrestrial plants). The endpoints derived from
the results of long-term laboratory studies that assess chronic effects are the NOAEL and
LOAEL for birds and mammals and no observed adverse effect concentration (NOAEC) and the
lowest observed adverse effect concentration (LOAEC) for fish and aquatic invertebrates. Risk
presumptions along with the corresponding RQs and LOCs are shown in the table below.

Risk Presumptions for Non-target Organisms

Risk Presumption

LOC

Terrestrial Animals

Acute High Risk

EEC/LC50 or LD50/sqft2 or LD50/day3

>0.5

-------
Acute Restricted Use
Acute Endangered Species

EEC/LC50 or LD50/sqft2 or LD50/day (or LD50 < 50
mg/kg)

EEC/LC50 or LD50/sqft2 or LD50/day

>0.2
>0.1

Chronic Risk

EEC/NOAEL

>1

Aquatic Animals

Acute High Risk

EEC/LC50 or EC50

>0.5

Acute Restricted Use

EEC/LC50 or EC50

>0.1

Acute Endangered Species

EEC/LC50 or EC50

>0.05

Chronic Risk

EEC/NOAEC

>1

Terrestrial and Semi-Aquatic Plants

Acute High Risk

EEC/EC25

>1

Acute Endangered Species

EEC/EC 50 or NOAEC

>1

Aquatic Plants

Acute High Risk

EEC/EC 50

>1

Acute Endangered Species

EEC/EC 50 or NOAEC

>1

EEC = Estimated environmental concentration

The calculated risk quotients represent a screening level assessment. Screening level
assessments are based on conservative assumptions. For example, screening level assessments
always assume the maximum labeled rate, the maximum number of applications, and the shortest
treatment interval between applications are always used.

1. Aquatic Organisms

Indaziflam is highly toxic (EC50 = 0.1-1 mg a.i./L) to freshwater and estuarine/marine fish,
moderately toxic (EC50 = 1 -10 mg a.i./L) to highly toxic (EC50 = 0.1-1 mg a.i./L) to estuarine
invertebrates, and slightly toxic (EC50 = 10 - 100 mg a.i./L) to moderately toxic (EC50 = 1 -10 mg
a.i./L) to freshwater invertebrates on an acute exposure basis. However, due to the proposed
uses of indaziflam and its subjectivity to aqueous photolysis, exposure to freshwater and
estuarine/marine fish and invertebrates is expected to be limited. All RQs for freshwater fish,
aquatic-phase amphibians, and freshwater invertebrates are below the LOC for acute and chronic
risk to listed and non-listed species. All RQs for estuarine and marine fish and invertebrates are
below the LOC for acute risk to listed and non-listed species. Chronic data is unavailable to
assess chronic effects on esturine/maine fish and invertebrates. Accordingly, risk to this taxon
was presumed in the risk estimation. An estimate of the chronic endpoint for estuarine/marine
fish is a NOAEC of 578 |ig total ai/L and RQs < 0.01. Based on this extrapolation, chronic risk
to estuarine/marine fish is not expected. Indaziflam's limited solubility under realistic conditions
will likely limit chronic effects to estuarine/marine invertebrates. However, due to the lack of
chronic effects data for estuarine/marine invertebrates, the Agency has to presume that
indaziflam is toxic to invertebrates for chronic exposure. Chronic effects studies for

27

-------
invertebrates are required. As is common with many herbicides, indaziflam is toxic to
nonvascular and vascular aquatic plants. The LOC was exceeded for aquatic vascular plants (see
page 71-72 of the Environmental Fate and Ecological Risk Assessment; RQ = 7-101) and aquatic
vascular and non-vascular plants listed under the Endangered Species Act (discussed further in
the document under Endangered Species Act).

The Agency's strategy to mitigate these risks involves label language that is intended to keep the
pesticide on the intended treatment area, and thereby reducing the potential for exposure to non-
target plants and animals. For example, buffer strips and spray drift management language will
be required on the labeling for EPA Reg. 432-RUOO (1499) BCS-AA10717 20WSP Herbicide,
which advises users of applicator responsibilities and offers specific techniques to reduce the
possibility of spray drift. In addition, the use of surface water advisories (as described above in
section A. Environmental Fate) will be required on all labeling, which may further reduce
possible exposure to non-target plants and animals.

2. Terrestrial Organisms

Indaziflam is practically nontoxic (LD50/LC5o > 2,000 mg a.i./L) to birds on both an acute oral
and subacute dietary exposure basis. As a minimum level of risk, none of the RQs for any
proposed use of indaziflam exceeded the Agency' s chronic risk to birds LOC of 1.0. However,
the maximum direct chronic risk to birds is unknown and can't be determined based on the
available data. For chronic studies, treatment-related effects on adult female weight gain, adult
male weight gain, and adult food consumption were observed in avian reproduction studies using
the mallard duck. Due to the lack of data, it is presumed that indaziflam is toxic to birds for
chronic exposure. A secondary study on the reproductive effects in the mallard duck is required.
Indaziflam is practically non-toxic (LD50> 2,000 mg a.i./L) to mammals on an acute and chronic
exposure basis. Indaziflam is practically nontoxic to honey bees. Affects to body weight were
observed to earthworms from a 14-day study at concentrations of 562-1000 mg a.i/kg dw soil.
An estimate of the expected concentration of indaziflam in real world soil conditions is 800
times smaller than the most sensitive effects endpoint from earthworm toxicity studies.

Therefore, the potential for risk to earthworms from exposure to indaziflam in soil is not
expected.

As is common with many herbicides, terrestrial plants are sensitive to indaziflam. The Agency's
LOC was exceeded for monocots and dicots (see page 75 of the Environmental Fate and
Ecological Risk Assessment; spray drift RQ = 1-11, dry area RQ = 2-23, and semi-aquatic area
RQ = 11-125) and listed terrestrial plants under the Endangered Species Act (discussed further in
the document under Endangered Species Act). Mitigating the risks to non-target terrestrial plants
and animals involves label language that is intended to keep the pesticide on the intended
treatment area.

VI. REGULATORY DECISION

The Agency registered a technical, a manufacturing use product, and seven end use products for
use on residential and commercial areas (lawns, ornamentals, and hardscapes including patios,
walkways, etc.), turf (parks, cemeteries, golf courses, sod farms, sports fields, and commercial

-------
lawns), field grown ornamentals and Christmas trees, commercial nursery and landscape
plantings, and forestry sites. As required by FIFRA, the Agency published a notice of receipt of
applications (dated January 27, 2010; no comments were received) to register pesticide products
containing the new active ingredient, indaziflam.

The human health risk assessment concluded that the database is complete and adequate for a
dietary, residential, and occupational assessment. The environmental fate and effects review
concluded that the database is adequate for a screening level assessment. However, because of
uncertainty regarding chronic risk to birds and estuarine and marine invertebrates, the Agency
has determined additional data requirements are required to better characterize risk. These
studies were required as a condition of the registration of indaziflam:

1. An additional avian reproduction study on Mallard duck (OPPTS 850.2300)

2. An estuarine/marine invertebrate life cycle toxicity study (OPPTS 850.1350)

In order to reduce the risk to non-target plant and animals the following label language was
required:

All End-Use Product Labels

"Ground Water Advisory: This pesticide has properties and characteristics associated with
chemicals detected in ground water. This chemical may leach into ground water if used in areas
where soils are permeable, particularly where the water table is shallow."

"Surface Water Advisory: This pesticide may impact surface water quality due to runoff of rain
water. This is especially true for poorly draining soils and soils with shallow ground water. This
product is classified as having a high potential for reaching surface water via runoff for several
months or more after application."

"Environmental Hazards

This Product is toxic to fish, aquatic invertebrates, and plants. Do not apply directly to water, or
to areas where surface water is present or to intertidal areas below the mean water mark. Do not
contaminate water when disposing of rinseate or washwater. This product may contaminate
water through spray drift or runoff. Follow directions for use to avoid spray drift and runoff. A
level well maintained vegetative buffer strip between areas to which this product is applied and
surface water features including ponds, streams, and springs will reduce the potential for
contamination of water from rainfall runoff. Runoff of this product will be reduced by avoiding
applications when rainfall is forecasted to occur within 48 hours."

All Manufacturing-Use Product Labels

"Environmental Hazards:

This pesticide is toxic to fish, aquatic invertebrates, and plants. Do not discharge effluent
containing this product into lakes, streams, ponds, estuaries, oceans or other water unless in
accordance with the requirements of a National Pollutant Discharge Elimination System
(NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do

-------
not discharge effluent containing this product into sewer systems without previously notifying
the local sewage treatment plant authority. For guidance, contact your State Water Board or
Regional Office of the EPA."

All Occupational Use Labels:

"For use on sod farms, golf courses, and non-crop areas (excluding lawns), do not apply within
25 feet of ponds, lakes, rivers, streams, ditches, wetlands, and habitat containing aquatic and
semi-aquatic plants. For forestry uses, do not apply within 50 feet of ponds, lakes, rivers,
streams, ditches, wetlands, and habitat containing aquatic and semi-aquatic plants."

"Do Not Apply by Air."

"Spray Drift Management

Spray equipment and weather affect spray drift. Consider all factors when making application
decisions. Where states have more stringent regulations, they must be observed. Avoiding spray
drift is the responsibility of the applicator or grower. To reduce the potential for drift, the
application equipment must be set to apply medium to large droplets (i.e., ASAE Standard 572)
with corresponding spray pressure. Use high flow rate nozzles to apply the highest practical
spray volume. With most nozzle types, narrower spray angles produce larger droplets. Follow
the nozzle manufacturer's directions on pressure, orientation, spray volume, etc., in order to
minimize drift and optimize coverage and control.

Golf Course, Residential, and Commercial Lawns

Set the boom and make applications at the lowest height that safely permits uniform coverage of
the soil and minimizes droplet evaporation. For use on golf courses and commercial lawns, the
boom height must be no higher than 3 feet above the ground and nozzles tips must be set to spray
out medium to very coarse spray droplets. Applications to residential lawns must be made by
equipment that maintains coarse spray droplets (to reduce drift).

Ornamentals

For deciduous ornamental plants, the spray must be directed at the base of the plant or away from
the plant but as not to come in contact with the foliage as some leaf malformations or
discoloration may occur. Dormant deciduous trees are tolerant to indaziflam herbicide.

Conifers including Christmas trees are tolerant to foliar applications of indaziflam. In Christmas
tree farm operations, direct the spray to the base of the trees on a band or broadcast application.

Wind

Avoid making applications when spray particles may be carried by air currents to areas where
sensitive crops and non-target plants are growing. Do not spray near sensitive plants if wind is
gusty, below 2 mph, or in excess of 10 mph and moving in the direction of adjacent areas of
sensitive crops or plants. Do not apply during temperature inversions. Always make
applications when there is some air movement to determine the direction and distance of possible
spray drift.

-------
Local terrain may influence wind patterns; the applicator must be familiar with local conditions
and understand how they may impact spray drift. Boom or nozzle shielding can reduce the
effects of wind or air currents on drift. Verify that the shields do not interfere with uniform
deposition of product prior to application.

Temperature Inversion

A surface temperature inversion (i.e., increasing temperature with increasing altitude) greatly
increases the potential for drift. Avoid application when conditions are favorable to inversion.
Presence of ground fog is a good indicator of a surface temperature inversion.

Sensitive Areas

Sensitive areas to this product are defined as bodies of water (ponds, lakes, rivers, streams, and
ditches), wetlands, habitat for endangered species, and non-labelled agricultural crop areas.
Applicators must take all precautions necessary to keep spray drift from reaching sensitive
areas."

Public Interest

The Agency believes that the registration of indaziflam is in the public interest (based on
"Review of Public Interest Finding Document of November 19, 2009). Indaziflam controls a
broad spectrum of weeds, including species which are difficult to eliminate (including blue grass,
goose grass, and crab grass). Indaziflam has greater efficacy in controlling annual blue grass in
turf compared to prodiamine and pendimethalin. Indaziflam has a unique mode of action which
is not found in other herbicides used for grass weed control and can be used as a tool in herbicide
resistant management programs in turf and ornamentals. Indaziflam can be used in combination
with other herbicides for a long-term and broader control of grasses and broadleaf weeds.
Indaziflam demonstrates lower carcinogenic potential compared to prodiamine, oxadiazon, and
pendimethalin (these active ingredients are considered carcinogens).

Endangered Species Act

The Endangered Species Act required federal agencies to ensure that their actions are not likely
to jeopardize listed species or adversely modify designated critical habitats. The Agency
generally will identify pesticides whose use may cause adverse impacts on federally listed
endangered and threatened species through the registration review program. If potential effects
are identified EPA will evaluate the need to take steps to mitigate those effects and will also
generally initiate consultation with the U.S. Fish and Wildlife Service and National Marine
Fisheries Service as appropriate, to obtain their biological opinion regarding the potential effects.

The ecological assessment that EPA conducted for this registration action does not, in itself,
constitute a determination as to whether a specific species or critical habitat may be harmed by
the pesticide. Rather, this assessment serves as a screen to determine the need for any species
specific assessment that will evaluate whether exposure may be at levels that could cause harm
to specific listed species and their critical habitat. That assessment refines the screening-level
assessment to take into account the geographic area of pesticide use in relation to the listed

-------
species, the habits and habitat requirements of the listed species, etc. If the Agency's specific
assessments for indaziflam result in the need to modify use of the pesticide, any geographically
specific changes to the pesticide's registration will be implemented through the process
described in the Agency's Federal Register Notice (54 FR 27984) regarding implementation of
the Endangered Species Protection Program. Until that species specific analysis is completed,
the risk mitigation measures being implemented through this registration action will help to
reduce the likelihood that endangered and threatened species may be exposed to indaziflam at
levels of concern.

A determination that there is a likelihood of potential effects to a listed species may result in
further limitations on the use of the pesticide, other measures to mitigate any potential effects,
and/or consultations with the Fish and Wildlife Service or National Marine Fisheries Service, as
necessary. If the Agency determines use of indaziflam "may affect" listed species or their
designated critical habitat, EPA will employ the provisions in the Services regulations (50 CFR
Part 402).

Contact Person at EPA

Jim Tompkins
Product Manager
Herbicide Branch
Registration Division (7505P)

Office of Pesticide Programs
Environmental Protection Agency
Aerial Rios Building
1200 Pennsylvania Ave., NW
Washington, DC 20460

DISCLAIMER: The information presented in this Pesticide Fact Sheet is for informational
purposes only and may not be used to fulfill data requirements for pesticide registration and
reregi strati on.

Bibliography

61-1 Chemical Identity

MRID Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

-------
47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

61-2 Description of Beginning Materials and Manufacturing Proces

MRU)

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide

33

-------
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

61-3 Discussion of Formation of Impurities

MRU)

Citation Reference

47443201

47488701

47488801

47488901

47489001

47489101

47489201

Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.
Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished

34

-------
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

62-1 Preliminary Analysis

MRID	Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

35

-------
62-2 Certification of limits

MRU)

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

62-3 Analytical Method

MRU)

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

36

-------
47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-2 Color

MRU)

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide

37

-------
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-3 Physical State

MRU)

Citation Reference

47443202

47488801

47488901

47489001

47489101

47489301

47489401

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-4 Odor

38

-------
mrii)

Citation Reference

47443202

47488801

47488901

47489001

47489101

47489301

47489401

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-5 Melting Point

MRU)

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-6 Boiling Point

MRID	Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study

39

-------
prepared by Bayer Corp. 664 p.

63-7 Density

MRID	Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-8 Solubility

MRID

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-9 Vapor Pressure

MRID

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

40

-------
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-11 Oct/Water partition Coef.

MRU)

Citation Reference

47443202

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-12 pH

MRU)

Citation Reference

47443202

47488801

47488901

47489001

47489101

47489401

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-13 Stability

MRU)

Citation Reference

41

-------
47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-14 Oxidizing/Reducting Action

MRU)

Citation Reference

47443202

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

63-15 Flammability

MRU)

Citation Reference

47489301

47489401

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-16 Explodability

MRU)

Citation Reference

47443202

47488801

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

63-17 Storage stability

MRU)

Citation Reference

42

-------
47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

63-18 Viscosity

MRU)

Citation Reference

47489301

47489401

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

63-20 Corrosion characteristics

MRU)

Citation Reference

47443202

47488801

47489301

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

71-1 Avian Single Dose Oral Toxicity

MRU)

Citation Reference

47443240

Stoughton, T. ; Christ, M. (2008) Toxicity of AE 1170437 Technical During an
Acute Oral LD50 with the Northern Bobwhite Quail (Colinus virginianus).

43

-------
Project Number: M/303029/01/1, EBDHP028. Unpublished study prepared by
Bayer CropScience. 29 p.

71-2 Avian Dietary Toxicity

MRID	Citation Reference

47443241	Stoughton, T.; Christ, M. ; Lam, C. (2008) Technical AE 1170437: A Subacute
Dietary LC50 with Northern Bobwhite. Project Number: M/303033/01/1,
EBDHP030. Unpublished study prepared by Bayer CropScience. 37 p.

47443242	Stoughton, T.; Lam, C. (2008) Technical AE 1170437: A Subacute Dietary
LC50 with Mallards. Project Number: M/303037/01/1, EBDHP031.
Unpublished study prepared by Bayer CropScience. 37 p.

71-4 Avian Reproduction

MRID	Citation Reference

47443243	Christ, M. ; Lam, C. (2008) Effect of Technical AE 1170437 on Northern
Bobwhite Quail (Colinus virginianus) Reproduction. Project Number:
M/304696/01/1, EBDHP032. Unpublished study prepared by Bayer
CropScience. 72 p.

47443244	Christ, M. ; Lam, C. (2008) Toxicity of AE 1170437 Technical on Reproduction
to the Mallard Duck (Anas platyrhynchos) and Modified Exposure of AE

1170437 Technical on Reproduction to the Mallard Duck (Anas platyrhynchos).
Project Number: M/304690/01/1, EBDHP033, EBUFL002. Unpublished study
prepared by Bayer CropScience. 121 p.

72-1 Acute Toxicity to Freshwater Fish

MRID	Citation Reference

47443229	Matlock, D.; Lam, C. (2008) Acute Toxicity of AE 1170437 Technical to the
Fathead Minnow (Pimephales promelas) under Static Conditions. Project
Number: M/302402/01/1, EBDHP122. Unpublished study prepared by Bayer
CropScience. 46 p.

47443230	Matlock, D.; Lam, C. (2008) Acute Toxicity of BCS_AA10365 (AE 1170437-
diaminotriazine) to the Fathead Minnow (Pimephales promelas) under Static
Conditions. Project Number: M/302862/01/1, EBDHP126. Unpublished study

44

-------
prepared by Bayer CropScience. 43 p.

47443231 Matlock, D.; Lam, C. (2008) Acute Toxicity of AE 2158969 (AE 1170437-
carboxylic acid) to the Fathead Minnow (Pimephales promelas) Under Static
Conditions. Project Number: M/302522/01/1, EBDHP125. Unpublished study
prepared by Bayer CropScience. 43 p.

47443233	Banman, C. ; Lam, C. (2007) Acute Toxicity of AE 1170437 Technical to the
Bluegill (Lepomis machrochirus) under Static Conditions. Project Number:
M/288881/01/1, EBDHP018. Unpublished study prepared by Bayer
CropScience. 41 p.

47443234	Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Acute Toxicity of AE 1170437
Technical to the Trout (Oncorhynchus mykiss) Under Static Conditions. Project
Number: M/293173/02/1, EBDHP039/1. Unpublished study prepared by Bayer
CropScience. 40 p.

72-2 Acute Toxicity to Freshwater Invertebrates

MRU)

Citation Reference

47443226 Banman, C.; Hoffmann, J.; Lam, C. (2006) Acute Toxicity of AE 1170437
Technical to the Daphnia magna under Static Conditions. Project Number:
M/282376/01/2, EBDHP021. Unpublished study prepared by Bayer
CropScience. 38 p.

72-3 Acute Toxicity to Estuarine/Marine Organisms
MRID	Citation Reference

47443232 Banman, C.; Lam, C. (2007) Acute Toxicity of AE 1170437 Technical to the
Sheepshead Minnow (Cyprinodon variegatus) Under Static Conditions. Project
Number: M/288882/01/1, EBDHP019. Unpublished study prepared by Bayer
CropScience. 43 p.

72-4 Fish Early Life Stage/Aquatic Invertebrate Life Cycle Study
MRID	Citation Reference

47443235 Banman, C. ; Roberts, J. ; Lam, C. (2007) Chronic Toxicity of AE 1170437
Technical to the Daphnia magna Under Static Renewal Conditions. Project
Number: M/291493/01/1, EBDHP053. Unpublished study prepared by Bayer

45

-------
CropScience. 69 p.

47443236 Banman, C. ; Roberts, J. ; Lam, C. (2007) Early Life Stage Toxicity of AE

1170437 Technical to the Fathead Minnow (Pimephales promelas) Under Flow-
through Conditions. Project Number: M/292051/01/1, EBDHP020. Unpublished
study prepared by Bayer CropScience. 100 p.

72-6 Aquatic org. accumulation

MRU)

Citation Reference

47443237

Matlock, D.; Fischer, D. (2008) [Triazine-2,4-(Carbon 14)] AE 1170437-
Bioconcentration and Biotransformation in Bluegill Sunfish (Lepomis
macrochirus). Project Number: M/303425/01/1, MEDHP026. Unpublished
study prepared by Bayer CropScience. 218 p.

81-1 Acute oral toxicity in rats

MRU)

Citation Reference

47488902

47489002

47489102

47489402

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11
P-

Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

81-2 Acute dermal toxicity in rabbits or rats

46

-------
mrii)

Citation Reference

47488902 Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

47489002 Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

47489102 Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11
P-

47489402 Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

81-3 Acute inhalation toxicity in rats

MRU)

Citation Reference

47488902

47489002

47489102

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11

47

-------
p-

47489402 Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

81-4 Primary eye irritation in rabbits

MRU)

Citation Reference

47488902

47489002

47489102

47489402

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11
P-

Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

81-5 Primary dermal irritation

MRU)

Citation Reference

47488902

47489002

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus

48

-------
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

47489102 Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11
P-

47489402 Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

81-6 Dermal sensitization

MRU)

Citation Reference

47488902

47489002

47489102

47489402

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0284 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-Specific and Extrapolated Data. Project
Number: M/304571/01/1, BES07/08/1, BES07/08/1A. Unpublished study
prepared by Bayer Environmental Sciience. lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0213 Percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Formulation-specific and Extrapolated Data. Project
Number: M/304580/01/1, BES07/08/2. Unpublished study prepared by Bayer
Environmental Science, lip.

Sargent, D. E. (2008) Acute Toxicity of BCS-AA10717 0.0142 percent Plus
Turf Fertilizer Herbicide: New Formulation Registration and Precautionary
Label Language Based on Extrapolated Data. Project Number: M/304590/01/1,
BES07/08/3. Unpublished study prepared by Bayer Environmental Science. 11
P-

Sargent, D. (2008) Acute Toxicity of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use: New Formulation Registration and Precautionary Label
Language Based on Extrapolated Data. Project Number: M/304229/01/1,
BA07/08. Unpublished study prepared by Bayer Advanced, lip.

123-1 Seed germination/seedling emergence and vegitative vigor

MRU)

Citation Reference

49

-------
47443246	Bach, F.; Nguyen, D. (2008) AE 1170437 WP 20 Percent w/w: Effects on the
Seedling Emergence and Seedling Growth of Ten Species of Non-target
Terrestrial Plants (Tier 2). Project Number: M/304041/01/2, SE/07/051,
EBDHP058. Unpublished study prepared by Bayer Cropscience AG. 269 p.

47443247	Bach, F.; Nguyen, D. (2008) AE 1170437 SC 500 g/L - Effects on the Seedling
Emergence and Seedling Growth of Twelve Species of Non-target Terrestrial
Plants (Tier 2). Project Number: M/301643/01/2, SE/07/029, EBDHP062.
Unpublished study prepared by Bayer Cropscience AG. 276 p.

47443248	Bach, F.; Gosch, H.; Nguyen, D. (2008) AE 1170437 WP 20 Percent w/w:
Effects on the Vegetative Vigour of Ten Species of Non-target Terrestrial Plants
(Tier 2). Project Number: M/303620/01/2, VV/07/052, EBDHP059.
Unpublished study prepared by Bayer Cropscience AG. 190 p.

47443249	Bach, F.; Gosch, H.; Nguyen, D. (2008) AE 1170437 SC 500 g/L - Effects on
the Vegetative Vigour of Eleven Species of Non-target Terrestrial Plants (Tier
2). Project Number: M/301645/01/2, VV/071030, VV/07/030. Unpublished
study prepared by Bayer Cropscience AG. 219 p.

123-2 Aquatic plant growth

MRU)

Citation Reference

47443261

47443262

47443264

47443265

47443266

Banman, C. ; Lam, C. (2008) Toxicity of AE 1170437 Technical to the Green
Alga Pseudokirchneriella subcapitata. Project Number: M/293679/02/1,
EBDHP022/1. Unpublished study prepared by Bayer CropScience. 50 p.

Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10365 (AE 1170437-1-Diaminotriazine) to the Green Alga
Pseudokirchneriella subcapitata. Project Number: M/301715/01/1, EBDHP048.
Unpublished study prepared by Bayer CropScience. 52 p.

Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10202 (AE 1170437-1-Hydroxyethyl) to the Green Alga Pseudokirchneriella
subcapitata. Project Number: M/301713/01/1, EBDHP057. Unpublished study
prepared by Bayer CropScience. 51 p.

Matlock, D.; Hoffmann, J.; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10201 (AE 1170437-1-Olefine) to the Green Alga Pseudokirchneriella
subcapitata. Project Number: M/302859/01/1, EBDHP056. Unpublished study
prepared by Bayer CropScience. 54 p.

Banman, C. S.; Lam, C. V. (2007) Toxicity of AE 1170437 Technical to the
Freshwater Diatom Navicula pelliculosa. Project Number: M/291758/01/1,
EBDHP024. Unpublished study prepared by Bayer CropScience. 59 p.

50

-------
47443267	Banman, C. ; Lam, C. (2007) Toxicity of AE 1170437 Technical to the
Saltwater Diatom Skeletonema costatum. Project Number: M/291753/01/1,
EBDHP025. Unpublished study prepared by Bayer CropScience. 60 p.

47443268	Banman, C.; Daly, R. ; Lam, C. (2007) Toxicity of AE 1170437 Technical to the
Blue Green Algae Anabaena flos-aquae. Project Number: M/294414/01/1,
EBDHP023. Unpublished study prepared by Bayer CropScience. 59 p.

154-22 Non-Target Plant Studies

MRID	Citation Reference

47743308 Dorgeerloh, M. (2008) Lemna gibba G3 - Growth Inhibition Test with AE
1170437 SC 500 Under Static Conditions. Project Number:
M/310262/01/2/OCR, EBDHP008, E412/3261/9. Unpublished study prepared
by Bayer CropScience. 101 p.

161-1 Hydrolysis

MRID	Citation Reference

47443207 Sneikus, J. (2007) [Triazine-2,4-(Carbon 14)] and [indane-3-13/(Carbon 14)]AE
1170437: Hydrolytic Degradation. Project Number: M/294681/01/2,
MEF/07/177, Ml 111669/5. Unpublished study prepared by Bayer CropScience
AG. 70 p.

161-2 Photodegradation-water

MRID	Citation Reference

47443208 Dehner, D.; Heinemann, O. (2006) [Indane-3-(Carbon 13)/(Carbon 14)] AE
1170437 and [triazine-2,4-(Carbon 14)] AE 1170437: Phototransformation in
Water. Project Number: M/283818/01/2, MEF/06/201, Ml 121572/9.
Unpublished study prepared by Bayer CropScience. 99 p.

161-3 Photodegradation-soil

MRID	Citation Reference

51

-------
47443209 Stupp, H.; Augustin, T. (2007) [Triazine-2,4-(Carbon 14)] and [indane-3-

(Carbon 13)/(Carbon 14)]AE 1170437: Phototransformation on Soil. Project
Number: M/295259/01/2, MEF/06/137, Ml 121506/6. Unpublished study
prepared by Bayer CropScience. 111 p.

162-1 Aerobic soil metabolism

MRID	Citation Reference

47443210	Shepherd, J. (2008) [Indane-3-(Carbon 13)/(Carbon 14)]AE 1170437: Aerobic
Soil Metabolism in Two US Soils. Project Number: M/296489/01/1,
MEDHP013. Unpublished study prepared by Bayer CropScience. 177 p.

47443211	Shepherd, J. (2008) [Triazine-2,4-(Carbon 14)]AE 1170437: Aerobic Soil
Metabolism in Two US Soils. Project Number: M/296492/01/1, MEDHP032.
Unpublished study prepared by Bayer CropScience. 186 p.

162-2 Anaerobic soil metabolism

MRID	Citation Reference

47443216 Stupp, H. (2006) [Triazine-2,4-(Carbon 14)] and [indane-3-(Carbon 13/Carbon
14)]AE 1170437: Anaerobic Soil Metabolism. Project Number: M/283258/01/2,
MEF/06/355, M1261526/3. Unpublished study prepared by Bayer CropScience
AG. 107 p.

162-3 Anaerobic aquatic metab.

MRID	Citation Reference

47443218	Mathew, A. (2007) [Indane-3-(Carbon 13/Carbon 14)]AE 1170437: Anaerobic
Aquatic Metabolism. Project Number: M/290001/01/2, MEDHP017.
Unpublished study prepared by Bayer CropScience. 64 p.

47443219	Mathew, A. (2007) [Triazine-2,4-(Carbon 14)]AE 1170437: Anaerobic Aquatic
Metabolism. Project Number: M/289074/01/2, MEDHP022. Unpublished study
prepared by Bayer CropScience. 64 p.

163-1 Leach/adsorp/desorption

MRID	Citation Reference

52

-------
47443203	Stupp, H.; Augustin, T. (2006) [Triazine-2,4-(Carbon 14)] AE 1170437:
Adsorption/Desorption on Five Soils. Project Number: M/274409/01/2,
MEF/05/383, M1311473/0. Unpublished study prepared by Bayer CropScience.
84 p.

47443204	Simmonds, M. (2006) [Carbon 14]-AE 1170437-triazine-indanone: Adsorption
to and Desorption from Five Soils. Project Number: M/275499/02/2,

CX/05/042. Unpublished study prepared by Battelle UK, Ltd. 99 p.

47443205	Simmonds, M. (2006) [Carbon 14J-AE 1170437-diaminotriazine: Adsorption to
and Desorption from Five Soils. Project Number: M/275442/01/2, CX/05/041.
Unpublished study prepared by Battelle UK, Ltd. 96 p.

47443206	Simmonds, M.; Brett, R. (2006) [Carbon 14J-AE 1170437-carboxylic acid:
Adsorption to and Desorption from Five Soils. Project Number: M/275561/01/2,
CX/05/043. Unpublished study prepared by Battelle UK, Ltd. 97 p.

164-1 Terrestrial field dissipation

MRU)

Citation Reference

47443220

47443221

47443222

47443223

47443224

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in California Soil
Cropped with Turf, 2006. Project Number: M/303529/01/1, MEDHP014.
Unpublished study prepared by Bayer CropScience, Agvise Laboratories, and
Research for Hire. 251 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in Florida Soil
Cropped with Turf, 2006. Project Number: M/303697/01/1, MEDHP035,
DH/002/S06/01. Unpublished study prepared by Bayer CropScience, Agvise
Laboratories, and Ag Research Associates. 240 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in North Carolina
Soil Cropped with Turf, 2006. Project Number: M/303532/01/1, MEDHP034,
DH/002/506/1. Unpublished study prepared by Bayer CropScience, Agvise
Laboratories, and Agricultural Systems Associates. 246 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in California Soil,
2006. Project Number: M/303704/01/1, MEDHP038, DH/002/S06/01.
Unpublished study prepared by Bayer CropScience, Agvise Laboratories, and
Research for Hire. 251 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in Florida Soil,
2006. Project Number: M/303702/01/1, MEDHP037, DH/002/S06/01.
Unpublished study prepared by Bayer CropScience, Agvise, Inc. and Ag
Research Associates. 242 p.

53

-------
47443225 Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in North Carolina
Soil, 2006. Project Number: M/303701/01/1, MEDHP036. Unpublished study
prepared by Bayer CropScience, Agvise Inc. and Agricultural Systems
Associates. 253 p.

47743301 Lenz, M. (2009) Terrestrial Field Dissipation of AE 1170437 in Washington
Soil, 2006. Project Number: M/345376/Ol/l/OCR, MEDHP019. Unpublished
study prepared by Bayer CropScience, Agvise Laboratories, Inc., and Quails Ag
Laboratory. 264 p.

165-4 Bioaccumulation in fish

MRU)

Citation Reference

47443237

Matlock, D.; Fischer, D. (2008) [Triazine-2,4-(Carbon 14)] AE 1170437-
Bioconcentration and Biotransformation in Bluegill Sunfish (Lepomis
macrochirus). Project Number: M/303425/01/1, MEDHP026. Unpublished
study prepared by Bayer CropScience. 218 p.

830.1550

MRU)

Product Identity and composition

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished

54

-------
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.1600 Description of materials used to produce the product

MRID	Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

55

-------
47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

47753301 Vermehren, J. (2009) Indaziflam (BCS-AA10717): Description of the

Manufacturing Process of the Technical Grade Active Substance: Manufactured
by Bayer CropScience, Kansas City (USA) or by Bayer CropScience AG,
Dormagen (Germany). Project Number: M/345140/01/3, G202048. Unpublished
study prepared by Bayer Cropscience Gmbh. 93 p.

830.1620

MRU)

Description of production process

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished

56

-------
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

47753301 Vermehren, J. (2009) Indaziflam (BCS-AA10717): Description of the

Manufacturing Process of the Technical Grade Active Substance: Manufactured
by Bayer CropScience, Kansas City (USA) or by Bayer CropScience AG,
Dormagen (Germany). Project Number: M/345140/01/3, G202048. Unpublished
study prepared by Bayer Cropscience Gmbh. 93 p.

830.1650

MRU)

Description of formulation process

Citation Reference

47488701

47488801

47488901

47489001

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide

57

-------
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.1670 Discussion of formation of impurities

MRID	Citation Reference

47443201

47488701

47488801

47488901

47489001

47489101

Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.
Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished

58

-------
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

47753302 Vermehren, J. (2009) Indaziflam (BCS-AA10717) Technical Material

Manufactured by Bayer CropScience at Kansas City (USA) or Dormagen
(Germany): Discussion of the Formation of Impurities. Project Number:
M/345137/01/3, G202031. Unpublished study prepared by Bayer CropScience.
21 p.

830.1700

MRU)

Preliminary analysis

Citation Reference

47443201

47488701

47488801

47488901

Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.
Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide

59

-------
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

47753303	Doller, U.; Klockner, C. (2009) Material Accountability of Indaziflam (BCS-
AA10717) Manufactured at Dormagen / Germany: Analytical Profile of
Production Batches. Project Number: M/345075/01/3, PA09/001,
AM012206FP3. Unpublished study prepared by Bayer Cropscience Gmbh. 151
P-

47753304	Doller, U.; Klockner, C. (2009) Material Accountability of Indaziflam BCS-
AA10717: Manufactured at Kansas City / USA: Analytical Profile of Production
Batches. Project Number: M/345079/01/3, PA09/002, AM12606FP3.
Unpublished study prepared by Bayer Cropscience Gmbh. 152 p.

830.1750

MRU)

Certified limits

Citation Reference

47443201

47488701

47488801

Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.
Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer

60

-------
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.1800

MRU)

Enforcement analytical method

Citation Reference

47443201 Fontaine, L. (2008) Product Chemistry of AA10717 Technical Herbicide.

Project Number: M/303832/01/1, BR/2637, ANR/03308. Unpublished study
prepared by Bayer CropScience. 701 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

61

-------
47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

47753305	Doller, U.; Klockner, C. (2009) Analytical Method: Determination of AE
2300072 and AE 2300090 in Technical Grade and Pure BCS-AA10717 by High
Performance Liquid Chromatography (HPLC). Project Number:

M/285033/04/2, AM012306FP3, AM12206FP3. Unpublished study prepared by
Bayer Cropscience Gmbh. 16 p.

47753306	Doller, U.; Klockner, C. (2009) Analytical Method: Determination of the
Impurities in Technical Grade and Pure BCS-AA10717 by High Performance
Liquid Chromatography (HPLC). Project Number: M/291457/03/2,
AM012206FP3, AM012506FP3. Unpublished study prepared by Bayer
Cropscience Gmbh. 25 p.

47753307	Doller, U.; Klockner, C. (2009) First Addendum to the Validation Report
AF06/065: Validation of HPLC-Method AM012206FP3: Determination of
Impurities in Technical Grade and Pure BCS-AA10717 by High Performance
Liquid Chromatography (HPLC). Project Number: M/329679/01/2, AF08/090,
AM012206FP3. Unpublished study prepared by Bayer Cropscience Gmbh. 23 p.

47753308

Doller, U.; Klockner, C. (2009) Analytical Method: Determination of the Sum

62

-------
of all Stereoisomers of BCS-AA10717 in Technical Grade and Pure Active
Substance by High Performance Liquid Chromatography (HPLC). Project
Number: M/290214/03/2, AM012606FP3. Unpublished study prepared by
Bayer Cropscience Gmbh. 14 p.

47753309	Doller, U.; Klockner, C. (2009) Analytical Method: Determination of the
Optical Purity of all Stereoisomers in Technical Grade and Pure BCS-AA10717
by Chiral High Performance Liquid Chromatography (HPLC). Project Number:
M/290216/03/2, AM012506FP3. Unpublished study prepared by Bayer
Cropscience Gmbh. 19 p.

47753310	Doller, U.; Klockner, C. (2009) First Addendum to the Validation Report
AF08/028: Validation of the HPLC-Method AM012306FP3: Determination of
AE 2300072 and AE 2300090 in Technical Grade and Pure BCS-AA10717 by
High Performance Liquid Chromatography (HPLC): Determination of the
Specificity of BCS-CN42745. Project Number: M/329683/01/2, AF09/001,
AM12306FP3. Unpublished study prepared by Bayer Cropscience Gmbh. 13 p.

47753311	Doller, U.; Klockner, C. (2009) First Addendum to the Validation Report
AF08/029: Validation of the HPLC-Method AM012506FP3: Determination of
the Optical Purity of all Stereoisomers in Technical Grade and Pure BCS-
AA10717 by Chiral High Performance Liquid Chromatography (HPLC):
Determination of the Specificity of BCS-CN42745. Project Number:
M/329686/01/2, AF08/089, AM12506FP3. Unpublished study prepared by
Bayer Cropscience Gmbh. 16 p.

47753312	Doller, U.; Klockner, C. (2009) First Addendum to the Validation Report
AF08/030: "Determination of the Sum of all Stereoisomers of BCS-AA10717 in
Technical Grade and Pure Active Substance by High Performance Liquid
Chromatography (HPLC)": Determination of the Specificity of BCS-CN42745 .
Project Number: M/329692/01/2, AF08/088, AM012606FP3. Unpublished
study prepared by Bayer Cropscience Gmbh. 13 p.

830.6302

MRU)

Color

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer

63

-------
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489201 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.6303

MRU)

Physical state

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

64

-------
47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.6304

MRU)

Odor

Citation Reference

47443202

47488801

47488901

47489001

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide

65

-------
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.6313
metal ions

Stability to sunlight, normal and elevated temperatures, metals, and

MRU)

Citation Reference

47443202

47743601

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.6314

MRU)

Oxidizing or reducing action

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.6315 Flammability

66

-------
Citation Reference

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639, Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Explodability

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Storage stability of product

Citation Reference

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer

-------
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Doller, U.; Eichelmann, Ch. (2008) Storage Stability and Corrosion
Characteristics of BCS-AA10717 Technical Grade Active Substance. Project
Number: M/308105/01/2, PA07/039. Unpublished study prepared by Bayer
Cropscience Gmbh. 43 p.

Miscibility

Citation Reference

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Corrosion characteristics

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

-------
Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Doller, U.; Eichelmann, Ch. (2008) Storage Stability and Corrosion
Characteristics of BCS-AA10717 Technical Grade Active Substance. Project
Number: M/308105/01/2, PA07/039. Unpublished study prepared by Bayer
Cropscience Gmbh. 43 p.

Dielectric breakdown voltage

Citation Reference

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

pH of water solutions or suspensions

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

-------
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7050
mrii)

UV/Visible absorption

Citation Reference

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7100 Viscosity

70

-------
Citation Reference

Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.
Project Number: M/302570/01/1, BR/2639, Unpublished study prepared by
Bayer CropScience. 65 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Melting point/melting range

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Boiling point/boiling range

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study

-------
prepared by Bayer CropScience. 456 p.

830.7300 Density/relative density

MRID	Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47488701 Huchet, G. (2008) Product Chemistry of AA-10717 2 Percent MUP Herbicide.

Project Number: M/302570/01/1, BR/2639. Unpublished study prepared by
Bayer CropScience. 65 p.

47488801 Huchet, G. (2008) Product Chemistry of AA01717 20 percent WP. Project
Number: M/302569/01/1, BR/2643. Unpublished study prepared by Bayer
CropScience. 120 p.

47488901 Huchet, G. (2008) Product Chemistry of AA10717 0.0284 Percent Herbicide

Plus Turf Fertilizer. Project Number: M/302854/01/1, BR/2642, 102000021294.
Unpublished study prepared by Bayer CropScience. 62 p.

47489001 Huchet, G. (2008) Product Chemistry of AA10717 0.0213 Percent Herbicide
Plus Turf Fertilizer. Project Number: M/302853/01/1, BR/2641. Unpublished
study prepared by Bayer CropScience. 62 p.

47489101 Huchet, G. (2008) Product Chemistry of AA10717 0.0142 percent Herbicide
Plus Turf Fertilizer. Project Number: M/302849/01/1, BR/2640. Unpublished
study prepared by Bayer CropScience. 62 p.

47489301 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Concentrate/RTS. Project Number: M/302512/01/1, BR/2634, 08FD032.
Unpublished study prepared by Bayer CropScience. 155 p.

47489401 Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Ready-to-Use. Project Number: M/302509/03/1, BR/2635/R2, 08FD033.
Unpublished study prepared by Bayer CropScience. 156 p.

47743501 Long, D. (2009) Product Chemistry of Indaziflam 200 SC Herbicide. Project
Number: M/348332/Ol/l/OCR, BR/2672, 1907/2006. Unpublished study
prepared by Bayer CropScience. 458 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7370 Dissociation constant in water

72

-------
mrii)

Citation Reference

47443202 Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.

Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

47743601 Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7550 Partition coefficient (n-octanol/water), shake flask method
MRID	Citation Reference

47743601

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7560 Partition coefficient (n-octanol/water), generator column method
MRID	Citation Reference

47443202

47743601

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7570 Partition coefficient (n-octanol/water), estimation by liquid
chromatography

MRID

Citation Reference

47743601

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

830.7840 Water solubility: Column elution method, shake flask method

73

-------
Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Water solubility, generator column method

Citation Reference

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Vapor pressure

Citation Reference

Fontaine, L. (2008) Product Chemistry of AA107171 Technical Herbicide.
Project Number: M/304175/1/1, PA06/060, PA07/021. Unpublished study
prepared by Bayer Corp. 664 p.

Huchet, G. (2008) Product Chemistry of Bayer Advanced Lawn 3FL Herbicide
Granule. Project Number: M/302511/01/1, BR/2636, 08FD051. Unpublished
study prepared by Bayer CropScience. 106 p.

Long, D. (2009) Product Chemistry of Indaziflam 500 SC Herbicide. Project
Number: M/348333/01/1, BR/2671, AM007205FF1. Unpublished study
prepared by Bayer CropScience. 456 p.

Soil column leaching

Citation Reference

Stupp, H.; Augustin, T. (2006) [Triazine-2,4-(Carbon 14)] AE 1170437:
Adsorption/Desorption on Five Soils. Project Number: M/274409/01/2,
MEF/05/383, M1311473/0. Unpublished study prepared by Bayer CropScience.

74

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84 p.

Simmonds, M. (2006) [Carbon 14]-AE 1170437-triazine-indanone: Adsorption
to and Desorption from Five Soils. Project Number: M/275499/02/2,

CX/05/042. Unpublished study prepared by Battelle UK, Ltd. 99 p.

Simmonds, M. (2006) [Carbon 14J-AE 1170437-diaminotriazine: Adsorption to
and Desorption from Five Soils. Project Number: M/275442/01/2, CX/05/041.
Unpublished study prepared by Battelle UK, Ltd. 96 p.

Simmonds, M.; Brett, R. (2006) [Carbon 14J-AE 1170437-carboxylic acid:
Adsorption to and Desorption from Five Soils. Project Number: M/275561/01/2,
CX/05/043. Unpublished study prepared by Battelle UK, Ltd. 97 p.

Hydrolysis of parent and degradates as a function of pH at 25 C

Citation Reference

Sneikus, J. (2007) [Triazine-2,4-(Carbon 14)] and [indane-3-13/(Carbon 14)]AE
1170437: Hydrolytic Degradation. Project Number: M/294681/01/2,
MEF/07/177, Ml 111669/5. Unpublished study prepared by Bayer CropScience
AG. 70 p.

Direct photolysis rate of parent and degradates in water

Citation Reference

Dehner, D.; Heinemann, O. (2006) [Indane-3-(Carbon 13)/(Carbon 14)] AE
1170437 and [triazine-2,4-(Carbon 14)] AE 1170437: Phototransformation in
Water. Project Number: M/283818/01/2, MEF/06/201, Ml 121572/9.
Unpublished study prepared by Bayer CropScience. 99 p.

Photodegradation of parent and degradates in soil

Citation Reference

Stupp, H.; Augustin, T. (2007) [Triazine-2,4-(Carbon 14)] and [indane-3-
(Carbon 13)/(Carbon 14)]AE 1170437: Phototransformation on Soil. Project
Number: M/295259/01/2, MEF/06/137, Ml 121506/6. Unpublished study
prepared by Bayer CropScience. 111 p.

Aerobic soil metabolism

-------
Citation Reference

Shepherd, J. (2008) [Indane-3-(Carbon 13)/(Carbon 14)]AE 1170437: Aerobic
Soil Metabolism in Two US Soils. Project Number: M/296489/01/1,
MEDHP013. Unpublished study prepared by Bayer CropScience. 177 p.

Shepherd, J. (2008) [Triazine-2,4-(Carbon 14)]AE 1170437: Aerobic Soil
Metabolism in Two US Soils. Project Number: M/296492/01/1, MEDHP032.
Unpublished study prepared by Bayer CropScience. 186 p.

Stupp, H.; Augustin, T. (2007) [Indane-3-(Carbon 13/14)] AE 1170437: Aerobic
Soil Metabolism in Four EU Soils. Project Number: M/295160/01/2,

MEF/06/19, M1251497/9. Unpublished study prepared by Bayer CropScience
AG. 98 p.

Stupp, H.; Augustin, T. (2007) [Triazine-2,4-(Carbon 14)]AE 1170437: Aerobic
Soil Metabolism in Four EU Soils. Project Number: M/290409/01/2,
MEF/06/299, M1251406/9. Unpublished study prepared by Bayer CropScience.
108 p.

Sneikus, J. (2008) [Triazine-2,4-(Carbon 14)]AE 1956114 (diaminotriazine):
Aerobic Soil Metabolism in Three EU Soils. Project Number: M/297565/01/2,
MEF/05/517, M1251511/6. Unpublished study prepared by Bayer CropScience.
80 p.

Heinemann, O. (2008) AE 1170437 and AE 1170438: Comparative Aerobic
Soil Degradation in Two EU Soils. Project Number: M/299297/01/2,
MEF/08/004, M1251704/0. Unpublished study prepared by Bayer CropScience.
78 p.

Anaerobic soil metabolism

Citation Reference

Stupp, H. (2006) [Triazine-2,4-(Carbon 14)] and [indane-3-(Carbon 13/Carbon
14)]AE 1170437: Anaerobic Soil Metabolism. Project Number: M/283258/01/2,
MEF/06/355, M1261526/3. Unpublished study prepared by Bayer CropScience
AG. 107 p.

Aerobic aquatic metabolism

Citation Reference

Stupp, H. (2007) [Triazine-2,4-(Carbon 14)] and [indane-3-Carbon 13/14)]AE

76

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1170437: Aerobic Aquatic Metabolism. Project Number: M/296164/01/2,
MEF/07/283, Ml511579/9. Unpublished study prepared by Bayer CropScience
AG. 131 p.

Anaerobic aquatic metabolism

Citation Reference

Mathew, A. (2007) [Indane-3-(Carbon 13/Carbon 14)]AE 1170437: Anaerobic
Aquatic Metabolism. Project Number: M/290001/01/2, MEDHP017.
Unpublished study prepared by Bayer CropScience. 64 p.

Mathew, A. (2007) [Triazine-2,4-(Carbon 14)]AE 1170437: Anaerobic Aquatic
Metabolism. Project Number: M/289074/01/2, MEDHP022. Unpublished study
prepared by Bayer CropScience. 64 p.

Terrestrial field dissipation

Citation Reference

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in California Soil
Cropped with Turf, 2006. Project Number: M/303529/01/1, MEDHP014.
Unpublished study prepared by Bayer CropScience, Agvise Laboratories, and
Research for Hire. 251 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in Florida Soil
Cropped with Turf, 2006. Project Number: M/303697/01/1, MEDHP035,
DH/002/S06/01. Unpublished study prepared by Bayer CropScience, Agvise
Laboratories, and Ag Research Associates. 240 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in North Carolina
Soil Cropped with Turf, 2006. Project Number: M/303532/01/1, MEDHP034,
DH/002/506/1. Unpublished study prepared by Bayer CropScience, Agvise
Laboratories, and Agricultural Systems Associates. 246 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in California Soil,
2006. Project Number: M/303704/01/1, MEDHP038, DH/002/S06/01.
Unpublished study prepared by Bayer CropScience, Agvise Laboratories, and
Research for Hire. 251 p.

Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in Florida Soil,
2006. Project Number: M/303702/01/1, MEDHP037, DH/002/S06/01.
Unpublished study prepared by Bayer CropScience, Agvise, Inc. and Ag
Research Associates. 242 p.

-------
Lenz, M. (2008) Terrestrial Field Dissipation of AE 1170437 in North Carolina
Soil, 2006. Project Number: M/303701/01/1, MEDHP036. Unpublished study
prepared by Bayer CropScience, Agvise Inc. and Agricultural Systems
Associates. 253 p.

Lenz, M. (2009) Terrestrial Field Dissipation of AE 1170437 in New York Soil,
2006. Project Number: M/346142/Ol/l/OCR, MEDHP033. Unpublished study
prepared by Bayer CropScience, Agvise Laboratories, Inc., and A.C.D.S.
Research, Inc. 268 p.

Aquatic invertebrate acute toxicity, test, freshwater daphnids

Citation Reference

Banman, C.; Hoffmann, J.; Lam, C. (2006) Acute Toxicity of AE 1170437
Technical to the Daphnia magna under Static Conditions. Project Number:
M/282376/01/2, EBDHP021. Unpublished study prepared by Bayer
CropScience. 38 p.

Banman, C.; Hoffmann, J.; Lam, C. (2008) Acute Toxicity of AE 1170437
SC500 to Daphnia magna Under Static Conditions. Project Number:
M/303022/01/1/OCR, EBDHP006. Unpublished study prepared by Bayer
CropScience. 42 p.

Bruns, E. (2009) Acute Toxicity of BCS-AA10717 SC 200 G to the Water Flea
Daphnia magna in a Static Laboratory Test System. Project Number:
M/345722/01/2/OCR, EBDHP112, E/320/3615/0. Unpublished study prepared
by Bayer CropScience. 57 p.

Oyster acute toxicity test (shell deposition)

Citation Reference

Gallagher, S.; Kendall, T.; Krueger, H. (2008) AE 1170437: A 96-hour Shell
Deposition Test with the Eastern Oyster (Crassostrea virginica). Project
Number: M/300719/01/1, EBDHP027, 149A/232A. Unpublished study prepared
by Wildlife International, Ltd. 62 p.

Mysid acute toxicity test

Citation Reference

-------
47443227 Gallagher, S.; Kendall, T.; Krueger, H. (2007) AE 1170437: A 96-hour Static
Acute Toxicity Test with the Saltwater mysid (Americamysis bahia). Project
Number: M/292052/01/1, EBDHP026, 148A/231. Unpublished study prepared
by Wildlife International, Ltd. 44 p.

850.1075 Fish acute toxicity test, freshwater and marine
MRID	Citation Reference

47443229	Matlock, D.; Lam, C. (2008) Acute Toxicity of AE 1170437 Technical to the
Fathead Minnow (Pimephales promelas) under Static Conditions. Project
Number: M/302402/01/1, EBDHP122. Unpublished study prepared by Bayer
CropScience. 46 p.

47443230	Matlock, D.; Lam, C. (2008) Acute Toxicity of BCS_AA10365 (AE 1170437-
diaminotriazine) to the Fathead Minnow (Pimephales promelas) under Static
Conditions. Project Number: M/302862/01/1, EBDHP126. Unpublished study
prepared by Bayer CropScience. 43 p.

47443231	Matlock, D.; Lam, C. (2008) Acute Toxicity of AE 2158969 (AE 1170437-
carboxylic acid) to the Fathead Minnow (Pimephales promelas) Under Static
Conditions. Project Number: M/302522/01/1, EBDHP125. Unpublished study
prepared by Bayer CropScience. 43 p.

47443232	Banman, C.; Lam, C. (2007) Acute Toxicity of AE 1170437 Technical to the
Sheepshead Minnow (Cyprinodon variegatus) Under Static Conditions. Project
Number: M/288882/01/1, EBDHP019. Unpublished study prepared by Bayer
CropScience. 43 p.

47443233	Banman, C. ; Lam, C. (2007) Acute Toxicity of AE 1170437 Technical to the
Bluegill (Lepomis machrochirus) under Static Conditions. Project Number:
M/288881/01/1, EBDHP018. Unpublished study prepared by Bayer
CropScience. 41 p.

47443234	Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Acute Toxicity of AE 1170437
Technical to the Trout (Oncorhynchus mykiss) Under Static Conditions. Project
Number: M/293173/02/1, EBDHP039/1. Unpublished study prepared by Bayer
CropScience. 40 p.

47743305 Ruhland, M. (2009) Acute Toxicity of AE 1170437 SC 500 G to Fish (Lepomis
macrochirus) Under Static Conditions. Project Number: M/304810/01/2/OCR,
EBDHP068, E/280/3404/1. Unpublished study prepared by Bayer CropScience.
56 p.

850.1300 Daphnid chronic toxicity test

79

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Citation Reference

Banman, C. ; Roberts, J. ; Lam, C. (2007) Chronic Toxicity of AE 1170437
Technical to the Daphnia magna Under Static Renewal Conditions. Project
Number: M/291493/01/1, EBDHP053. Unpublished study prepared by Bayer
CropScience. 69 p.

Fish early-life stage toxicity test

Citation Reference

Banman, C. ; Roberts, J. ; Lam, C. (2007) Early Life Stage Toxicity of AE
1170437 Technical to the Fathead Minnow (Pimephales promelas) Under Flow-
through Conditions. Project Number: M/292051/01/1, EBDHP020. Unpublished
study prepared by Bayer CropScience. 100 p.

Fish BCF

Citation Reference

Matlock, D.; Fischer, D. (2008) [Triazine-2,4-(Carbon 14)] AE 1170437-
Bioconcentration and Biotransformation in Bluegill Sunfish (Lepomis
macrochirus). Project Number: M/303425/01/1, MEDHP026. Unpublished
study prepared by Bayer CropScience. 218 p.

Avian acute oral toxicity test

Citation Reference

Stoughton, T. ; Christ, M. (2008) Toxicity of AE 1170437 Technical During an
Acute Oral LD50 with the Northern Bobwhite Quail (Colinus virginianus).
Project Number: M/303029/01/1, EBDHP028. Unpublished study prepared by
Bayer CropScience. 29 p.

Avian dietary toxicity test

Citation Reference

80

-------
Stoughton, T.; Christ, M. ; Lam, C. (2008) Technical AE 1170437: A Subacute
Dietary LC50 with Northern Bobwhite. Project Number: M/303033/01/1,
EBDHP030. Unpublished study prepared by Bayer CropScience. 37 p.

Stoughton, T.; Lam, C. (2008) Technical AE 1170437: A Subacute Dietary
LC50 with Mallards. Project Number: M/303037/01/1, EBDHP031.
Unpublished study prepared by Bayer CropScience. 37 p.

Avian reproduction test

Citation Reference

Christ, M. ; Lam, C. (2008) Effect of Technical AE 1170437 on Northern
Bobwhite Quail (Colinus virginianus) Reproduction. Project Number:
M/304696/01/1, EBDHP032. Unpublished study prepared by Bayer
CropScience. 72 p.

Christ, M. ; Lam, C. (2008) Toxicity of AE 1170437 Technical on Reproduction
to the Mallard Duck (Anas platyrhynchos) and Modified Exposure of AE
1170437 Technical on Reproduction to the Mallard Duck (Anas platyrhynchos).
Project Number: M/304690/01/1, EBDHP033, EBUFL002. Unpublished study
prepared by Bayer CropScience. 121 p.

Honey bee acute contact toxicity

Citation Reference

Barth, M. (2006) Acute Toxicity of AE 1170437 A.I. Tech. to the Honeybee
Apis melliferaL. Under Laboratory Conditions: Final Report. Project Number:
M/280047/02/2, 06/10/48/064. Unpublished study prepared by Biochem Agrar,
Labor fuer Biologische und Chemische. 35 p.

Barth, M. (2006) Acute Toxicity of AE 1170437 SC 500 to the Honeybee Apis
mellifera L. Under Laboratory Conditions: Final Report. Project Number:
M/279427/01/2/OCR, 06/10/48/130. Unpublished study prepared by Biochem
Agrar, Labor fuer Biologische und Chemische Analytik. 30 p.

Seedling emergence, Tier II

Citation Reference

Bach, F.; Nguyen, D. (2008) AE 1170437 WP 20 Percent w/w: Effects on the

-------
Seedling Emergence and Seedling Growth of Ten Species of Non-target
Terrestrial Plants (Tier 2). Project Number: M/304041/01/2, SE/07/051,
EBDHP058. Unpublished study prepared by Bayer Cropscience AG. 269 p.

Bach, F.; Nguyen, D. (2008) AE 1170437 SC 500 g/L - Effects on the Seedling
Emergence and Seedling Growth of Twelve Species of Non-target Terrestrial
Plants (Tier 2). Project Number: M/301643/01/2, SE/07/029, EBDHP062.
Unpublished study prepared by Bayer Cropscience AG. 276 p.

Vegetative vigor, Tier II

Citation Reference

Bach, F.; Gosch, H.; Nguyen, D. (2008) AE 1170437 WP 20 Percent w/w:
Effects on the Vegetative Vigour of Ten Species of Non-target Terrestrial Plants
(Tier 2). Project Number: M/303620/01/2, VV/07/052, EBDHP059.
Unpublished study prepared by Bayer Cropscience AG. 190 p.

Bach, F.; Gosch, H.; Nguyen, D. (2008) AE 1170437 SC 500 g/L - Effects on
the Vegetative Vigour of Eleven Species of Non-target Terrestrial Plants (Tier
2). Project Number: M/301645/01/2, VV/071030, VV/07/030. Unpublished
study prepared by Bayer Cropscience AG. 219 p.

Aquatic plant toxicity test using Lemna spp. Tiers I and II

Citation Reference

Dorgerloh, M. (2007) Lemna gibba G3 - Growth Inhibition Test with BCS-
AA10717 (tech.) Under Static Conditions. Project Number: M/283650/02/2,
EBDHX009, E/412/3212/5. Unpublished study prepared by Bayer CropScience
AG. 254 p.

Dorgerloh, M. (2008) Lemna gibba G3 Growth Inhibition Test with AE

2158968	(AE 1170437-triazine-indanone) Under Static Conditions. Project
Number: M/301522/01/2, EBDHP052, E/412/3336/2. Unpublished study
prepared by Bayer CropScience AG. 91 p.

Dorgerloh, M. (2008) Lemna gibba G3 Growth Inhibition Test with BCS-
AA10365 (AE 1170437-diaminotriazine) Under Static Conditions. Project
Number: M/301519/01/2, EBDHP047, E/412/3335/1. Unpublished study
prepared by Bayer CropScience AG. 97 p.

Dorgerloh, M. (2008) Lemna Gibba G3 Growth Inhibition Test with AE

2158969	(AE 1170437-carboxylic acid) Under Static Conditions. Project
Number: M/303700/01/2, EBDHP044, E/412/3414/9. Unpublished study

-------
prepared by Bayer CropScience AG. 98 p.

47443254	Dorgerloh, M. (2008) Lemna gibba G3 Growth Inhibition Test with BCS-
AA10202 (AE 1170437-1-hydroxyethyl) Under Static Conditions. Project
Number: M/301528/01/2, EBDHP054, E/412/3353/1. Unpublished study
prepared by Bayer CropScience. 94 p.

47443255	Dorgerloh, M. (2008) Lemna gibba G3 Growth Inhibition Test with BCS-
AA10201 (AE 1170437-olefine) Under Static Conditions. Project Number:
M/301973/01/2, EBDHP055, E/412/3352/0. Unpublished study prepared by
Bayer CropScience AG. 93 p.

47443256	Dorgerloh, M. (2006) Lemna gibba G3 Growth Inhibition Test with AE

1170437 in a Water/Sediment System Using Spiked Water (code: AE 1170437-
TE-01). Project Number: M/277397/02/2, EBDHP040, E/412/3148/3.
Unpublished study prepared by Bayer CropScience AG. 174 p.

850.4450

MRU)

Aquatic plants field study, Tier III

Citation Reference

47443257

47443258

47443259

47443260

47743309

47743310

Brock, T ; Bruns, E.; Crum, S. (2008) Ecological Effects of the Herbicide
AE1170437 in Outdoor Experimental Ponds Inhabited with Macrophytes.
Project Number: M/304567/01/2, A/L/T/SC/2007/1. Unpublished study
prepared by Alterra, Green World Research. 280 p.

Hoberg, J. (2008) AE 1170437 - Effects on Aquatic Macrophytes in Outdoor
Simulated Ponds. Project Number: M/303082/01/1, EBDHX004, 13798/6176.
Unpublished study prepared by Springborn Smithers Laboratories. 45 p.

Brumhard, B.; Schneider, U. (2008) Analysis of AE 1170437 Concentrations in
Sediment Samples of ALTERRA Study No. ALT. SC.2007.1. Project Number:
M/298851/01/2, MR/07/329, P671/071822. Unpublished study prepared by
Bayer CropScience AG. 34 p.

Krebber, R.; Sandau, C. (2008) Analysis of AE 1170437 Concentrations in
Water Samples of ALTERRA Study No. ALT.SC.2007.1. Project Number:
M/299709/01/2, MR/07/298, P674/077033. Unpublished study prepared by
Bayer CropScience AG. 43 p.

Banman, C.; Hoffman, J.; Lam, C. (2009) Toxicity of AE 1170437 Technical to
the Green Alga Pseudokirchneriella subcapitata. Project Number:
M/345923/01/1, EBDHX013. Unpublished study prepared by Bayer
CropScience. 59 p.

Banman, C.; Hoffmann, J.; Lam, C. (2008) Toxicity of the Formulation AE
1170437 SC500 to the Green Alga Pseudokirchneriella subcapitata. Project
Number: M/302761/01/1/OCR, EBDHP007. Unpublished study prepared by

83

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Bayer CropScience. 50 p.

Bruns, E. (2009) Pseudokirchneriella subcapitata Growth Inhibition Test with
Indaziflam SC 200 G. Project Number: M/349017/01/2/OCR, EBDHP113,
E/323/3585/9. Unpublished study prepared by Bayer CropScience. 71 p.

Algal toxicity, Tiers 1 and II

Citation Reference

Banman, C. ; Lam, C. (2008) Toxicity of AE 1170437 Technical to the Green
Alga Pseudokirchneriella subcapitata. Project Number: M/293679/02/1,
EBDHP022/1. Unpublished study prepared by Bayer CropScience. 50 p.

Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10365 (AE 1170437-1-Diaminotriazine) to the Green Alga
Pseudokirchneriella subcapitata. Project Number: M/301715/01/1, EBDHP048.
Unpublished study prepared by Bayer CropScience. 52 p.

Banman, C. ; Hoffmann, J. ; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10202 (AE 1170437-1-Hydroxyethyl) to the Green Alga Pseudokirchneriella
subcapitata. Project Number: M/301713/01/1, EBDHP057. Unpublished study
prepared by Bayer CropScience. 51 p.

Matlock, D.; Hoffmann, J.; Lam, C. (2008) Toxicity of the Metabolite BCS-
AA10201 (AE 1170437-1-Olefine) to the Green Alga Pseudokirchneriella
subcapitata. Project Number: M/302859/01/1, EBDHP056. Unpublished study
prepared by Bayer CropScience. 54 p.

Banman, C. S.; Lam, C. V. (2007) Toxicity of AE 1170437 Technical to the
Freshwater Diatom Navicula pelliculosa. Project Number: M/291758/01/1,
EBDHP024. Unpublished study prepared by Bayer CropScience. 59 p.

Banman, C. ; Lam, C. (2007) Toxicity of AE 1170437 Technical to the
Saltwater Diatom Skeletonema costatum. Project Number: M/291753/01/1,
EBDHP025. Unpublished study prepared by Bayer CropScience. 60 p.

Banman, C.; Daly, R. ; Lam, C. (2007) Toxicity of AE 1170437 Technical to the
Blue Green Algae Anabaena flos-aquae. Project Number: M/294414/01/1,
EBDHP023. Unpublished study prepared by Bayer CropScience. 59 p.

Nature of the residue - plants, livestock

Citation Reference

Krolski, M. ; Nguyen, T. (2008) The Metabolism of [Indane-3-14C] and

-------
[Triazine-2,4-14C] AE 1170437 in Sugarcane. Project Number: M/302672/01/1,
MEDHP005. Unpublished study prepared by Bayer CropScience. 64 p.

47743318	Nguyen, T.; Krolski, M. (2009) The Metabolism of [Indane-3-(Carbon 14)] and
[Triazine-2,4-(Carbon 14)] AE 1170437 in Apples. Project Number:
M/344398/Ol/l/OCR, MEDHP008, MEDHP010. Unpublished study prepared
by Bayer CropScience. 71 p.

47743319	Krolski, M.; Nguyen, T. (2009) The Metabolism of [Indane-3-(Carbon 14)] and
[Triazine-2,4-(Carbon 14)] AE 1170437 in Grapes. Project Number:
M/344727/Ol/l/OCR, MEDHP007, MEDHP009. Unpublished study prepared
by Bayer CropScience. 70 p.

47743320	Fisher, D. (2009) The Metabolism of [Triazine-2,4-(Carbon 14)] AE 1170437 in
the Lactating Goat. Project Number: M/347312/Ol/l/OCR, MEDHP027.
Unpublished study prepared by Bayer CropScience. 204 p.

47743321	Fischer, D. (2009) The Metabolism of [Indane-3-(Carbon 14)] AE 1170437 in
the Lactating Goat. Project Number: M/347315/Ol/l/OCR, MEDHP028.
Unpublished study prepared by Bayer CropScience and Southwest Bio-Labs,
Inc. 172 p.

860.1340

MRU)

Residue analytical method

Citation Reference

47443270

47443271

47443273

Xu, T. (2008) In House Validation of an Analytical Method for the
Determination of Residues of AE1170437 and its Metabolites AE1170437
Carboxylic Acid (AE2158969), AE1170437 Triazine-indanone (AE2158968),
AE1170437 Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201),
and AE1170437 Diaminotriazine (1-Fluoroethyl Traizinediamine) in Soil and
Sediment Using LC/MS/MS. Project Number: M/298966/01/1, RADHP046,
DH/002/S06/01. Unpublished study prepared by Bayer CropScience. 107 p.

Xu, T. (2008) In House Laboratory Validation of an Analytical Method for the
Determination of Residues of AE1170437 and its Metabolites AE1170437 Acid
(AE2158969), AE1170437 Triazine-indanone (AE2158968), AE1170437
Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201), and AE
1170437 Diaminotriazine (1-Fluoroethyl Triazinediamine) in Water Using
LC/MS/MS. Project Number: M/303387/01/1, RADHP043. Unpublished study
prepared by Bayer CropScience. 75 p.

Xu, T. (2008) Method of Analysis for the Determination of Residues of
AE1170437 and its Metabolites AE1170437 Carboxylic Acid (AE2158969),
AE1170437 Triazine-indanone (AE2158968), AE1170437 Hydroxyethyl
(AE2300077), AE1170437 Olefin (BCS-AA10201), and AE1170437
Diaminotriazine (1-Fluoroethyl Triazinediamine) in Water Using LC/MS/MS.

85

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Project Number: M/302676/02/1, DH/005/W07/02. Unpublished study prepared
by Bayer CropScience. 53 p.

47443275	Xu, T.; Seymour, R. (2008) Method of Analysis for the Determination of
Residues of AE1170437 and its Metabolites AE1170437 Carboxylic Acid
(AE2158969), AE1170437 Triazine-Indanone (AE2158968), AE1170437
Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201), and
AE1170437 Diaminotriazine (1-Fluoroethyl Triazinediamine) in Soil and
Sedimet Using LC/MS/MS. Project Number: M/298513/01/1, DH/002/S06/01.
Unpublished study prepared by Bayer CropScience. 61 p.

47443276	Xu, T.; Seymour, R. (2008) Method of Analysis for the Determination of
Residues of AE1170437 and its Metabolites AE1170437 Carboxylic Acid
(AE2158969), AE1170437 Triazine-Indanone (AE2158968), AE1170437
Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201), and
AE1170437 Diaminotriazine (1-Fluoroethy Triazinediamine) in Soil and
Sediment Using LC/MS/MS. Project Number: M/298513/02/1, DH/002/S06/02.
Unpublished study prepared by Bayer CropScience. 55 p.

47443277	Xu, T. (2008) Enforcement Method for the Determination of Residues of
AE1170437 and its Metabolites AE1170437 Carboxylic Acid (AE2158969),
AE1170437 Triazine-Indanone (AE2158968), and AE1170437 Diaminotriazine
(1-fluoroethyl triazinediamine) in Soil and Sediment Using LC/MS/MS. Project
Number: M/299109/01/1, DH/006/S08/01. Unpublished study prepared by
Bayer CropScience. 51 p.

47443278	Schmeer, K.; Loehrwald, K. (2007) Independent Laboratory Validation of
Method DH-002-S06-01 for the Determination of AE1170437 and its
Metabolites AE1170437 Carboxylic Acid (AE2158969), AE1170437 Triazine-
Indanone (AE2158968), AE1170437 Hydroxyethyl (AE2300077), AE1170437
Olefin (BCS-AA10201) and AE1170437 Diaminotriazine (1-Fluoroethyl
Triazinediamine) in Soil and Sediment Using LC-MS/MS. Project Number:
M/290907/01/2, MR/07/253. Unpublished study prepared by Bayer
CropScience. 44 p.

47743323	Timberlake, B. (2009) Validation of Bayer CropScienceMethod DH-003-P07-01
and DH-003-P07-02 - An Analytical Method for the Determination of Residues
of AE1170437 in Fruit and Tree Nut Matrices Using LC/MS/MS-Revised.
Project Number: M/349201/01/1/OCR, RADHP040. Unpublished study
prepared by Bayer CropScience. 297 p.

47743324	Dallstream, K. (2009) Radiovalidation of Bayer Method DH-003-P07-01 - An
Analytical Method for the Determination of Residues of AE 1170437 in Crop
Matricies Using LC/MS/MS. Project Number: M/347745/Ol/l/OCR,
RADHP047. Unpublished study prepared by Bayer CropScience. 35 p.

47743325	Merdian, H. (2009) Independent Laboratory Validation of Bayer Method DH-
003-P07-01 for the Determination of Residues of Indaziflam (AE 1170437) and
its Metabolite 1-Fluoroethyl Triazinediamine in Plant Materials, Using

86

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LC/MS/MS. Project Number: M/342267/01/2/OCR, P612097523, P/B/1633/G.
Unpublished study prepared by PTRL Europe Gmbh. 49 p.

Simpson, R.; Bennett, R. (2009) Independent Laboratory Validation of Method
DH-003-P07-02 for the Determination of Residues of AE1170437 and its
Diaminotriazine Metabolites in Crop Matrices Using LC/MS/MS-Revised: Final
Report. Project Number: M/349152/Ol/l/OCR, RADHP079, KP/2009/32.
Unpublished study prepared by JRF America. 244 p.

Multiresidue method

Citation Reference

Rockwell, D. (2009) PAM I Multiresidue Protocol Testing of AE 1170437
(Indaziflam) and its Metabolite 1-Fluoroethyl Triazinediamine. Project Number:
M/346696/Ol/l/OCR, RADHP072, 2008. Unpublished study prepared by
Pyxant Labs, Inc. 107 p.

Storage stability data

Citation Reference

Netzband, D. (2008) Stability of AE1170437 and its Metabolites (AE1170437
Acid, AE1170437 ketone, AE1170437 Hydroxy, AE1170437 Olefin,
AE1170437 Diaminotriazine) in Soil During Frozen Storage (Reported Through
a Maximum of 433 Days Storage). Project Number: M/302527/01/1,
RADHP041. Unpublished study prepared by Bayer CropScience. 56 p.

Netzeband, D. (2009) Stability of AE1170437 and its Metabolites (AE1170437
Acid, AE1170437 Ketone, AE1170437 Hydroxy, AE1170437 Olefin,
AE1170437 Diaminotriazine) in Soil During Frozen Storage (Reported Through
a Maximum of 736 Days Storage). Project Number: M/302527/02/l/OCR,
RADHP041/1. Unpublished study prepared by Bayer CropScience. 56 p.

Timberlake, B. (2009) Storage Stability of AE 1170437 and 1-Fluoroethyl
Triazinediamine in / on Fruit and Nut Matrices. Project Number:
M/348221/Ol/l/OCR, RADHP039. Unpublished study prepared by Bayer
CropScience. 138 p.

Meat/milk/poultry/eggs

Citation Reference

-------
Mislankar, S. (2009) Waiver of the Requirement for a Livestock Feeding Study
for Indaziflam. Project Number: MEDHP074, M/347958/01/1. Unpublished
study prepared by Bayer CropScience. 9 p.

Crop field trials

Citation Reference

Desmarteau, D.; Fischer, D. (2009) AE 1170437 500 SC - Magnitude of the
Residue in/on Pome Fruit (CG 11). Project Number: M/348053/01/1,
RADHP029, M/348053/01/1/OCR. Unpublished study prepared by Bayer
CropScience. 199 p.

Krolski, M.; Brungardt, J.; Stoughton, S. (2009) AE 1170437 500 SC -
Magnitude of the Residue in/on Stone Fruit (CG 12). Project Number:
M/347950/01/1, RADHP030, M/347950/01/1/OCR. Unpublished study
prepared by Bayer CropScience. 246 p.

Brungardt, J.; Krolski, M. (2009) AE 1170437 500 SC - Magnitude of the
Residue in/on Tree Nuts (CG 14). Project Number: M/347601/01/1,
RADHP028, M/344601/01/1/OCR. Unpublished study prepared by Bayer
CropScience. 197 p.

Fischer, D.; Harbin, A. (2009) AE 1170437 500 SC - Magnitude of the Residue
in/on Citrus (CG 10). Project Number: M/348968/01/1, RADHP027,
M/348968/Ol/l/OCR. Unpublished study prepared by Bayer CropScience. 273
P-

Sturdivant, D.; Fischeer, D. (2009) AE 1170437 500 SC - Magnitude of the
Residue in/on Grapes. Project Number: M/348344/01/1, RADHP033,
M/348344/Ol/l/OCR. Unpublished study prepared by Bayer CropScience. 143
P-

Timberlake, B.; Fischer, D. (2009) AE 1170437 500 SC - Magnitude of the
Residue in/on Olives. Project Number: M/348345/01/1, RADHP037,
M/348345/Ol/l/OCR. Unpublished study prepared by Bayer CropScience. 93 p.

Mislankar, S. (2009) Proposed Tolerance (Maximum Residue Levels) for
Indaziflam in Grapes, Citrus, Pome Fruits, Stone Fruits, Tree Nuts, and Olives.
Project Number: RADHP078, M/348689/01/1. Unpublished study prepared by
Bayer CropScience. 24 p.

Processed food/feed

Citation Reference

88

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Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue in/on
Sugarcane Processed Commodities. Project Number: M/348217/01/1,
RADHP018, M/348217/Ol/l/OCR. Unpublished study prepared by Bayer
CropScience and GLP Technologies. 89 p.

Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue in/on Apple
Processed Commodities. Project Number: M/348056/01/1, RADHP011,
M/348056/01/1/OCR. Unpublished study prepared by Bayer CropScience and
University of Idaho. 81 p.

Stoughton, S.; Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue
in/on Plum Processed Commodities. Project Number: M/347951/01/1,
RADHP012, M/347951/01/1/OCR. Unpublished study prepared by Bayer
CropScience and GLP Technologies. 80 p.

Stoughton, S.; Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue
in/on Orange Processed Commodities. Project Number: M/347960/01/1,
RADHP013, M/347960/01/1/OCR. Unpublished study prepared by University
of Idaho and Bayer CropScience. 85 p.

Stoughton, S.; Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue
in/on Grape Processed Commodities. Project Number: M/348051/01/1,
RADHP014, M/348051/01/1/OCR. Unpublished study prepared by Bayer
CropScience and University of Idaho, Cooperative Extension. 118 p.

Stoughton, S.; Lenz, C. (2009) AE 1170437 500 SC - Magnitude of the Residue
in/on Olive Processed Commodities. Project Number: M/348052/01/1,
RADHP015, M/348052/01/1/OCR. Unpublished study prepared by Bayer
CropScience and GLP Technologies. 78 p.

Proposed tolerances

Citation Reference

Mislankar, S. (2009) Proposed Tolerance (Maximum Residue Levels) for
Indaziflam in Grapes, Citrus, Pome Fruits, Stone Fruits, Tree Nuts, and Olives.
Project Number: RADHP078, M/348689/01/1. Unpublished study prepared by
Bayer CropScience. 24 p.

Confined accumulation in rotational crops

Citation Reference

-------
47743431 Mislankar, S. (2009) Waiver of the Requirement for a Confined Rotational Crop
Study for Indaziflam (MRID 47743414). Project Number: MEDHP072,
M/347957/01/1. Unpublished study prepared by Bayer CropScience. 6 p.

870.1100 Acute oral toxicity

MRID	Citation Reference

47443280	Schuengel, M. (2006) AE 1170437 - Acute Toxicity in the Rat after Oral
Administration. Project Number: M/273027/01/2, AT03047. Unpublished study
prepared by Bayer CropScience. 27 p.

47443281	Schuengel, M. (2007) AE 1170437 - Acute Toxicity in the Rat after Oral
Administration. Project Number: M/294505/01/2, AT04235, T/1078231.
Unpublished study prepared by Bayer HealthCare AG. 30 p.

47488702 Durando, J. (2008) Acute Oral Toxicity Up and Down Procedure in Rats - AA
10717 5 Percent MUP. Project Number: M/304193/01/1, 24047, P320/UDP.
Unpublished study prepared by Product Safety Laboratories. 15 p.

47488802 Schuengel, M. (2007) AE 1170437 WP 20 - Acute Toxicity in the Rat after Oral
Administration. Project Number: M/289026/01/2, AT03848, T/2077828.
Unpublished study prepared by Bayer HealthCare AG. 29 p.

47489202 Moore, G. (2008) Acute Oral Toxicity Up and Down Procedure in Rats - 3FL
Herbicide Granule. Project Number: M/303511/01/1, 24410, P320/UDP.
Unpublished study prepared by Product Safety Laboratories. 15 p.

47489302 Moore, G. (2008) Acute Oral Toxicity Up and Down Procedure in Rats - Bayer
Advanced Lawn 3FL Herbicide Concentrate. Project Number: M/304206/01/1,
24434, P320/UDP. Unpublished study prepared by Product Safety Laboratories.
15 p.

47743502 Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

47743602 Schungel, M. (2007) AE 1170437 SC 500 (Spec No 102000014236) - Acute

Toxicity in the Rat After Oral Administration. Project Number: M/294230/01/2,
AT04069, T6077903. Unpublished study prepared by Bayer HealthCare AG. 30
P-

47753314 Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

870.1200 Acute dermal toxicity

90

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Citation Reference

Schuengel, M. (2006) AE 1170437 - Acute Toxicity in the Rat after Dermal
Application. Project Number: M/273528/01/2, AT03066, T/2076603.
Unpublished study prepared by Bayer HealthCare AG. 29 p.

Durando, J. (2008) Acute Dermal Toxicity Study in Rats - Limit Test - AA
10717 5 Percent MUP. Project Number: M/304195/01/1, 24048, P322/RAT.
Unpublished study prepared by Product Safety Laboratories. 15 p.

Schuengel, M. (2007) AE 1170437 WP 20 (Spec N° 102000014590) - Acut
Toxicity in the Rat after Dermal Application. Project Number: M/289129/01/2,
AT03867, T/3077829. Unpublished study prepared by Bayer HealthCare AG.
30 p.

Moore, G. (2008) Acute Dermal Toxicity Study in Rats - Limit Test - 3FL
Herbicide Granule. Project Number: M/303513/01/1, 24411, P322/RAT.
Unpublished study prepared by Product Safety Laboratories. 15 p.

Moore, G. (2008) Acute Dermal Toxicity Study in Rats - Limit Test - Bayer
Advanced Lawn 3FL Herbicide Concentrate. Project Number: M/304208/01/1,
24435, P322/RAT. Unpublished study prepared by Product Safety Laboratories.
15 p.

Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

Schungel, M. (2007) AE 1170437 SC 500 (Spec No 102000014236) - Acute
Toxicity in the Rat After Dermal Application. Project Number: M/294233/01/2,
AT04070, T7077904. Unpublished study prepared by Bayer HealthCare AG. 29
P-

Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

Acute inhalation toxicity

Citation Reference

Folkerts, A. (2007) AE 1170437 Technical - Acute Inhalation Study in the Rat -
Activity ID TXDHP041 - Acute Inhalation Toxicity in Rats. Project Number:
M/290839/01/2, AT03932, T0077484. Unpublished study prepared by Bayer
HealthCare AG. 83 p.

-------
47488704 Durando, J. (2008) Acute Inhalation Toxicity Study in Rats - Limit Test - AA
10717 5 Percent MUP. Project Number: M/304196/01/1, 24049, P330.
Unpublished study prepared by Product Safety Laboratories. 23 p.

47488804 Pauluhn, J. (2007) AE 1170437 WP 20 (Spec No 102000014590) - Acute
Inhalation Toxicity in Rats. Project Number: M/290110/01/2, AT03916,
T6077499. Unpublished study prepared by Bayer HealthCare AG. 78 p.

47489204 Moore, G. (2008) Acute Inhalation Toxicity Study in Rats - Limit Test - 3FL

Herbicide Granule. Project Number: M/303514/01/1, 24412, P330. Unpublished
study prepared by Product Safety Laboratories. 22 p.

47489304 Durando, J. (2008) Acute Inhalation Toxicity Study in Rats - Limit Test - Bayer
Advanced Lawn 3FL Herbicide Concentrate. Project Number: M/304182/01/1,
24436, P330. Unpublished study prepared by Product Safety Laboratories. 22 p.

47743502 Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

47743604 Folkerts, A. (2007) AE 1170437 SC 500 (Spec No 102000014236) - Activity ID
TXDHP052 - Acute Inhalation Toxicity in Rats. Project Number:
M/294261/01/2, AT04055, T3077504. Unpublished study prepared by Bayer
HealthCare AG. 78 p.

47753314 Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

870.2400

MRU)

Acute eye irritation

Citation Reference

47443284

47488705

47488805

Schuengel, M. (2006) AE 1170437 - Acute Eye Irritation on Rabbits. Project
Number: M/275763/01/2, AT03200, T/1076558. Unpublished study prepared by
Bayer HealthCare AG. 23 p.

Durando, J. (2008) Primary Eye Irritation Study in Rabbits - AA 10717 5
Percent MUP. Project Number: M/304197/01/1, 24050, P324. Unpublished
study prepared by Product Safety Laboratories. 18 p.

Gmelin, C. (2007) AE 1170437 WP 20 (Spec No 102000014590) 1st
Amendment to AT03838 - Acute Eye Irritation on Rabbits. Project Number:
M/289351/02/1, AT03838/A, T/0077565. Unpublished study prepared by Bayer
HealthCare AG. 32 p.

47489205

Moore, G. (2008) Primary Eye Irritation Study in Rabbits - 3FL Herbicide

92

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Granule. Project Number: M/303516/01/1, 24413, P324. Unpublished study
prepared by Product Safety Laboratories. 16 p.

47489305 Moore, G. (2008) Primary Eye Irritation Study in Rabbits - Bayer Advanced
Lawn 3FL Herbicide Concentrate. Project Number: M/304186/01/1, 24437,
P324. Unpublished study prepared by Product Safety Laboratories. 18 p.

47743502 Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

47743605 Gmelin, C. (2007) AE 1170437 SC 500 (Spec No 102000014236) - Acute Eye
Irritation on Rabbits. Project Number: M/292520/01/2, AT04083, T/1077584.
Unpublished study prepared by Bayer HealthCare AG. 25 p.

47753314 Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

870.2500
mrii)

Acute dermal irritation

Citation Reference

47443285

47488706

47488806

47489206

47489306

47743502

Schuengel, M. (2006) AE 1170437 - Acute Skin irritation/Corrosion on Rabbits.
Project Number: M/275741/01/2, AT03201, T/0976556. Unpublished study
prepared by Bayer HealthCare AG. 23 p.

Durando, J. (2008) Primary Skin Irritation Study in Rabbits - AA 10717 5
Percent MUP. Project Number: M/304200/01/1, 24051, P326. Unpublished
study prepared by Product Safety Laboratories. 16 p.

Gmelin, C. (2007) AE 1170437 WP 20 (Spec No 102000014590) - Acute Skin
Irritation/Corrosion on Rabbits. Project Number: M/289350/01/2, AT03837,
T/9077564. Unpublished study prepared by Bayer HealthCare AG. 25 p.

Moore, G. (2008) Primary Skin Irritation Study in Rabbits - 3FL Herbicide
Granule. Project Number: M/303519/01/1, 24414, P326. Unpublished study
prepared by Product Safety Laboratories. 16 p.

Moore, G. (2008) Primary Skin Irritation Study in Rabbits - Bayer Advanced
Lawn 3FL Herbicide Concentrate. Project Number: M/304189/01/1, 24438,
P326. Unpublished study prepared by Product Safety Laboratories. 16 p.

Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

93

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47743606 Gmelin, C. (2007) AE 1170437 SC 500 (Spec No 102000014236) - Acute Skin
Irritation/Corrosion on Rabbits. Project Number: M/292515/01/2, AT04082,
T/9077582. Unpublished study prepared by Bayer HealthCare AG. 25 p.

47753314 Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

870.2600
mrii)

Skin sensitization

Citation Reference

47443286 Repetto-Larsay, M. (2006) AE 1170437 - Evaluation of Potential Dermal

Sensitization in the Local Lymph Node Assay in the Mouse. Project Number:
M/273140/01/2, SA/06098, AE/1170437. Unpublished study prepared by Bayer
Cropscience. 41 p.

47488707 Durando, J. (2008) Dermal Sensitization Study in Guinea Pig (Buehler Method)

-	AA 10717 5 Percent MUP. Project Number: M/304203/01/1, 24052, P328.
Unpublished study prepared by Product Safety Laboratories. 25 p.

47488807 Repetto-Larsay, M. (2007) AE 1170437 WP 20 (Spec No 102000014590) -

Evaluation of Potential Dermal Sensitization in the Local Lymph Node Assay in
the Mouse. Project Number: M/289453/01/2, SA/07074. Unpublished study
prepared by Bayer Cropscience. 38 p.

47489207 Moore, G. (2008) Dermal Sensitization Study in Guinea Pigs (Buehler Method)

-	3FL Herbicide Granule. Project Number: M/303521/01/1, 24415, P328.
Unpublished study prepared by Product Safety Laboratories. 24 p.

47489307 Durando, J. (2008) Dermal Sensitization Study in Guinea Pigs (Buehler

Method) - Bayer Advanced Lawn 3FL Herbicide Concentrate. Project Number:
M/304190/01/1, 24439, P328. Unpublished study prepared by Product Safety
Laboratories. 23 p.

47743502 Sargent, D. (2009) Acute Toxicity of BCS-AA10717 200SC Herbicide: New
Formulation Registration and Precautionary Label Language Based on
Extrapolated Data. Project Number: M/347080/01/1/OCR, BCS050409.
Unpublished study prepared by Bayer CropScience. 10 p.

47743607 Vohr, W. (2009) BCS-AA10717 SC 500 (Project: BCS-AA10717) - Study For
the Skin Sensitization Effect in Guinea Pigs (Buehler Patch Test). Project
Number: M/344749/01/2, AT05177, TXDHP107. Unpublished study prepared
by Bayer Ag Inst, of Toxicology. 30 p.

870.3100 90-Day oral toxicity in rodents

94

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Citation Reference

McElligott, A. (2005) AE 1170437 - 90-Day Toxicity Study in the Rat by
Dietary Administration. Project Number: M/250576/01/3, SA/04093.
Unpublished study prepared by Bayer Cropscience. 693 p.

McElligott, A. (2005) AE 1170437 - 90-Day Toxicity Study in the Mouse by
Dietary Administration. Project Number: M/246281/01/3, SA/04094.
Unpublished study prepared by Bayer Cropscience. 317 p.

90-day oral toxicity in nonrodents

Citation Reference

Eigenberg, D. (2008) A 90-Day Toxicity Study in the Beagle Dog with
Technical Grade BCS-AA10717 Administered by Oral Gavage. Project
Number: M/303436/01/1, 201630, 06/S16/DL. Unpublished study prepared by
Bayer CropScience LP. 582 p.

21/28-day dermal toxicity

Citation Reference

Schladt, L. (2006) AE 1170437 - (Project AE 1170437) - Subacute Toxicity
Study in Wistar Rats (4 Weeks Dermal Administration). Project Number:
M/278706/01/3, AT03278, T3076802. Unpublished study prepared by Bayer
HealthCare AG. 268 p.

Prenatal developmental toxicity study

Citation Reference

Wason, S. (2006) AE 1170437 - Developmenal Toxicity Study in the Rat by
Gavage. Project Number: M/279583/01/2, SA06012. Unpublished study
prepared by Bayer Cropscience. 219 p.

Wason, S. (2008) BCS-AA10717 - Study Type: Prenatal Developmental
Toxicity Study - Rabbit. Project Number: M/297239/01/2, SA/07017.
Unpublished study prepared by Bayer Cropscience. 284 p.

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Reproduction and fertility effects

Citation Reference

Milius, A. ; Stuart, B. (2008) Technical Grade BCS-AA10717: A Two
Generation Reproductive Toxicity Study in the Wistar Rat. Project Number:
M/303771/01/1, 201833, 07/R72/IH. Unpublished study prepared by Bayer
CropScience LP. 1745 p.

Chronic toxicity

Citation Reference

Eigenberg, D. (2008) A One Year Toxicity Feeding Study in the Beagle Dog
with Technical Grade BCS-AA10717. Project Number: M/303526/01/1,

201740, 06/C76/FY. Unpublished study prepared by Bayer CropScience LP.
973 p.

Jensen, T. (2007) A Homogeneity and Stability Study of AE 1170437 Technical
in Canine Ration. Project Number: M/293734/01/1, 201738, 06/H76/GO.
Unpublished study prepared by Bayer CropScience LP. 24 p.

C arcinogenicity

Citation Reference

Kennel, P. (2008) BCS AA10717 - Carcinogenicity Study in the C57BL/6J
Mouse by Dietary Administration. Project Number: M/312600/01/2, SA/05252,
M/312600/01/2/OCR. Unpublished study prepared by Bayer Cropscience. 2051
P-

Combined chronic toxicity/carcinogenicity

Citation Reference

Langrand-Lerche, C. (2007) AE 1170437 - Chronic Toxicity and
Carcinogenicity Study of AE 1170437 in the Wistar Rat by Dietary
Administration (12-Month Interim Report). Project Number: M/295231/01/2,
SA/05251, LYNX/PSI/N/TXDHP004. Unpublished study prepared by Bayer
Cropscience. 880 p.

96

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Langrand-Lerche, C. (2009) Chronic Toxicity and Carcinogenicity Study of
BCS-AA10717 in the Wistar Rat by Dietary Administration. Project Number:
M/295231/02/2, SA/05251, M/295231/02/2/OCR. Unpublished study prepared
by Bayer Cropscience. 3949 p.

Bacterial reverse mutation test

Citation Reference

Herb old, B. (2006) AE 1170437 Technical - (Project: AE 1170437) -
Salmonella/Microsome Test Plate Incorporation and Preincubation Method.
Project Number: M/278724/01/2, AT03273, T/3076145. Unpublished study
prepared by Bayer HealthCare AG. 62 p.

Herbold, B. (2007) 6-(l-Fluorophenyl)-l,3,5-Triazin-2,4-Diamine (Tested as
BCS-AA10365) (Project: AE1170437) - Salmonella/Microsome test - Plate
Incorporation and Preincubation Method. Project Number: M/290157/01/2,
AT03908, T/2077198. Unpublished study prepared by Bayer HealthCare AG.
64 p.

Herbold, B. (2008) AE 1170437 - Salmonella/Microsome Test - Plate
Incorporation and Preincubation Method: TXDHP077. Project Number:
M/301458/01/2, AT04336. Unpublished study prepared by Bayer HealthCare
AG. 65 p.

Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

In vitro mammalian cell gene mutation test

Citation Reference

Herbold, B. (2007) AE 1170437 Technical - V79/HPRT- Test in vitro for the
Detection of Induced Forward Mutations. Project Number: M/278721/01/2,
AT03274. Unpublished study prepared by Bayer HealthCare AG. 42 p.

Entian, G. (2007) 6-(l-fluoroethyl)-l,3,5-triazine-2,4-diamine (Tested as BCS-
AA10365) (Project: AE 1170437) - V79/HPRT Test in vitro for the Detection of
Induced Forward Mutations. Project Number: M/294379/01/2, AT04097.
Unpublished study prepared by Bayer HealthCare AG. 44 p.

Entian, G. (2008) AE 1170437-Carboxylic acid (Project: AE 1170437)
V79/HPRT-Test in vitro for the Detection of Induced Forward Mutations.

Project Number: M/300941/01/2, AT04536. Unpublished study prepared by

-------
Bayer HealthCare AG. 45 p.

Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

In vitro mammalian chromosome aberration test

Citation Reference

Nern, M. (2007) AE 1170437 (Tested as AE 1170437 Technical) (Project: AE
1170437) - In vitro Chromosome Aberration Test with Chinese Hamster V79
Cells. Project Number: M/279463/01/2, AT03323. Unpublished study prepared
by Bayer HealthCare AG. 58 p.

Thum, M. (2007) 6-(l-fluoroethyl)-l,3,5-triazine-2,4-diamine (Tested as BCS-
AA10365) (Project: AE 1170437) - In vitro Chromosome Aberration Test with
Chinese Hamster V79 Cells. Project Number: M/290175/01/2, AT03918.
Unpublished study prepared by Bayer HealthCare AG. 54 p.

D'Acquisto, M. (2008) AE 1170437-carboxylic acid - In vitro Chromosome
Aberration Test with Chinese Hamster V79 Cells. Project Number:
M/301573/01/2, AT04343. Unpublished study prepared by Bayer HealthCare
AG. 55 p.

Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

Mammalian erythrocyte micronucleus test

Citation Reference

Herb old, B. (2007) AE 1170437 Technical (Project: AE 1170437) -
Micronucleus-Test on the Male Mouse. Project Number: M/277278/01/2,
AT03227. Unpublished study prepared by Bayer HealthCare AG. 57 p.

Sargent, D. (2009) Indaziflam (BCS-AA 10717): Toxicity Data in Support of
the Technical Grade Active Ingredient (TGAI). Project Number: BES/052909,
M/348331/01/1. Unpublished study prepared by Bayer CropScience LP. 7 p.

Neurotoxicity screening battery

Citation Reference

-------
Gilmore, R. ; Hoss, H. (2008) A Subchronic Neurotoxicity Screening Study with
Technical Grade BCS-AA10717 in WistarRats. Project Number:
M/297947/01/1, 201749, 06/N72/GK. Unpublished study prepared by Bayer
CropScience. 600 p.

Gilmore, R.; Hoss, H. (2008) An Acute Oral Neurotoxicity Screening Study
with Technical Grade BCS-AA10717 in Wistar Rats. Project Number:
M/301098/01/1, 201782, 07/N12/JX. Unpublished study prepared by Bayer
CropScience. 565 p.

Developmental neurotoxicity study

Citation Reference

Sheets, L.; Gilmore, R. ; Hoss, H. (2008) A Developmental Neurotoxicity Study
with Technical Grade BCS-AA10717 in WistarRats. Project Number:
M/303709/01/1, 201877, 07/D72/KC. Unpublished study prepared by Bayer
CropScience. 1139 p.

Metabolism and pharmacokinetics

Citation Reference

Krolski, M. ; Nguyen, T. (2008) Metabolism of [14 Carbon] AE 1170437 in
Rats. Project Number: M/303441/01/1, MEDHP016. Unpublished study
prepared by Bayer CropScience. 159 p.

Krolski, M.; Nguyen, T. (2009) Metabolism of [Carbon 14] AE 1170437 in Rats
(Additional Groups). Project Number: M/345676/01/1, MEDHP023,
M/345676/Ol/l/OCR. Unpublished study prepared by Bayer CropScience. 171
P-

Dermal penetration

Citation Reference

Rascle, J. (2007) AE 1170437 - Comparative in vitro Dermal Absorption Study
Using Human and Rat Skin. Project Number: M/295685/01/2, SA/07078,
M/295685/01/2/OCR. Unpublished study prepared by Bayer Cropscience. 127
P-

99

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Blanck, M. (2008) BCS-AA10717 SC 500 - in vivo Dermal Absorption Study in
the Male Rat. Project Number: M/303747/01/2, SA/08041,
LYNX/PSI/NTXDHP043. Unpublished study prepared by Bayer Cropscience.
176 p.

Young, B. (2009) Occupational Exposure and Risk Assessment for Indaziflam
(BCS-AA10717) from Use on Pome Fruits, Stone Fruits, Tree Nuts, and Grapes
in Canada. Project Number: M/348957/01/1, G202063, M/348957/Ol/l/OCR.
Unpublished study prepared by Bayer CropScience. 15 p.

Immunotoxicity

Citation Reference

Reissmueller, E.; Vohr, H. (2008) BCS-AA107017 - Subacute Oral
Immunotoxicity Study in Wistar Rats (4 weeks Administration by Diet). Project
Number: M/302132/01/2, AT04595, T7078589. Unpublished study prepared by
Bayer HealthCare AG. 111 p.

Dermal exposure—Indoor

Citation Reference

Young, B. (2009) Occupational Exposure and Risk Assessment for Indaziflam
(BCS-AA10717) from Use on Fruit Trees, Tree Nuts, Vines and Industrial
Vegetation Management in the United States. Project Number: M/348956/01/1,
G202062, M/348956/Ol/l/OCR. Unpublished study prepared by Bayer
CropScience. 21 p.

Inhalation exposure—outdoor

Citation Reference

Young, B. (2009) Occupational Exposure and Risk Assessment for Indaziflam
(BCS-AA10717) from Use on Fruit Trees, Tree Nuts, Vines and Industrial
Vegetation Management in the United States. Project Number: M/348956/01/1,
G202062, M/348956/Ol/l/OCR. Unpublished study prepared by Bayer
CropScience. 21 p.

Inhalation exposure—indoor

100

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Citation Reference

Young, B. (2009) Occupational Exposure and Risk Assessment for Indaziflam
(BCS-AA10717) from Use on Fruit Trees, Tree Nuts, Vines and Industrial
Vegetation Management in the United States. Project Number: M/348956/01/1,
G202062, M/348956/Ol/l/OCR. Unpublished study prepared by Bayer
CropScience. 21 p.

Whole sediment: acute freshwater invertebrates

Citation Reference

Putt, A. (2008) AE1170437 - Toxicity to Midge (Chironomus tentans) During a
10-day Sediment Exposure. Project Number: M/302577/01/1, EBDHP067,
13798/6208. Unpublished study prepared by Springborn Smithers Laboratories.
69 p.

Whole sediment: acute marine invertebrates

Citation Reference

Putt, A. (2008) AE1170437 - Toxicity to Marine Amphipods (Leptocheirus
plumulosus) During a 10-day Sediment Exposure. Project Number:
M/302580/01/1, EBDHP066, 13798/6209. Unpublished study prepared by
Springborn Smithers Laboratories. 62 p.

Earthworm subchronic toxicity test

Citation Reference

Leicher, T. (2007) AE 1170437, Substance Technical: Acute Toxicity to
Earthworms (Eisenia fetida) Tested in Artificial Soil with 5 Percent Peat. Project
Number: M/284352/01/2, LRT/RG/A/81/07, E/310/3202/1. Unpublished study
prepared by Bayer CropScience. 25 p.

Data reporting for environmental chemistry methods

Citation Reference

-------
47443270	Xu, T. (2008) In House Validation of an Analytical Method for the
Determination of Residues of AE1170437 and its Metabolites AE1170437
Carboxylic Acid (AE2158969), AE1170437 Triazine-indanone (AE2158968),
AE1170437 Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201),
and AE1170437 Diaminotriazine (1-Fluoroethyl Traizinediamine) in Soil and
Sediment Using LC/MS/MS. Project Number: M/298966/01/1, RADHP046,
DH/002/S06/01. Unpublished study prepared by Bayer CropScience. 107 p.

47443271	Xu, T. (2008) In House Laboratory Validation of an Analytical Method for the
Determination of Residues of AE1170437 and its Metabolites AE1170437 Acid
(AE2158969), AE1170437 Triazine-indanone (AE2158968), AE1170437
Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201), and AE

1170437 Diaminotriazine (1-Fluoroethyl Triazinediamine) in Water Using
LC/MS/MS. Project Number: M/303387/01/1, RADHP043. Unpublished study
prepared by Bayer CropScience. 75 p.

47443274 Krebber, R.; Sandau, C. (2008) Independent Laboratory Validation of Method
DH-005-W07-01 for the Determination of Residues of AE1170437 and its
Metabolites AE1170437 Carboxylic Acid (AE2158969), AE1170437 Triazine-
indanone (AE2158968), AE1170437 Hydroxyethyl (AE2300077), AE1170437
Olefin (BCS-AA10201) and AE1170437 Diaminotriazine (1-Fluoroethyl
Triazinediamine) in Water Using LC-MS/MS. Project Number: M/303527/01/2,
DH/005/W07/01, MR/08/055. Unpublished study prepared by Bayer
CropScience. 53 p.

47443276	Xu, T.; Seymour, R. (2008) Method of Analysis for the Determination of
Residues of AE1170437 and its Metabolites AE1170437 Carboxylic Acid
(AE2158969), AE1170437 Triazine-indanone (AE2158968), AE1170437
Hydroxyethyl (AE2300077), AE1170437 Olefin (BCS-AA10201), and
AE1170437 Diaminotriazine (1-Fluoroethy Triazinediamine) in Soil and
Sediment Using LC/MS/MS. Project Number: M/298513/02/1, DH/002/S06/02.
Unpublished study prepared by Bayer CropScience. 55 p.

47443277	Xu, T. (2008) Enforcement Method for the Determination of Residues of
AE1170437 and its Metabolites AE1170437 Carboxylic Acid (AE2158969),
AE1170437 Triazine-indanone (AE2158968), and AE1170437 Diaminotriazine
(1-fluoroethyl triazinediamine) in Soil and Sediment Using LC/MS/MS. Project
Number: M/299109/01/1, DH/006/S08/01. Unpublished study prepared by
Bayer CropScience. 51 p.

47443278	Schmeer, K.; Loehrwald, K. (2007) Independent Laboratory Validation of
Method DH-002-S06-01 for the Determination of AE1170437 and its
Metabolites AE1170437 Carboxylic Acid (AE2158969), AE1170437 Triazine-
indanone (AE2158968), AE1170437 Hydroxyethyl (AE2300077), AE1170437
Olefin (BCS-AA10201) and AE1170437 Diaminotriazine (1-Fluoroethyl
Triazinediamine) in Soil and Sediment Using LC-MS/MS. Project Number:
M/290907/01/2, MR/07/253. Unpublished study prepared by Bayer

102

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CropScience. 44 p.

850.6200 Earthworm subchronic toxicity test

MRU)

Citation Reference

47743312	Leicher, T. (2008) AE 1170437-Diaminotriazine (BCS-AA10365): Acute
Toxicity to Earthworms (Eisenia fetida) Tested in Artificial Soil with 5 Percent
Peat. Project Number: M/293838/01/2/OCR, LRT/RG/A/93/07,

LRT/RA/A/93/07. Unpublished study prepared by Bayer CropScience. 24 p.

47743313	Leicher, T. (2007) AE 1170437-Triazine-indanone (AE 2158968): Acute
Toxicity to Earthworms (Eisenia fetida) Tested in Artificial Soil with 5 Percent
Peat. Project Number: M/291691/01/2/OCR, LRT/RG/A/89/07, E/310/3291/9.
Unpublished study prepared by Bayer CropScience. 24 p.

47743314	Leicher, T. (2008) AE 1170437-Carboxylic Acid (AE 2158969): Acute Toxicity
to Earthworms (Eisenia fetida) Tested in Artificial Soil with 5 Percent Peat.
Project Number: M/295984/01/2/OCR, LRT/RG/A/97/07, E/310/3405/6.
Unpublished study prepared by Bayer CropScience. 24 p.

47743315	Leicher, T. (2008) BCS-AA10717 SC 500 G: Acute Toxicity to Earthworms
(Eisenia fetida) Tested in Artificial Soil with 5 Percent Peat. Project Number:
M/312230/01/2/OCR, LRT/RG/A/111/08, EBDHP014. Unpublished study
prepared by Bayer CropScience. 24 p.

47743316	Leicher, T. (2007) AE 1170437 SC 500 G: Effects on Survival, Growth and
Reproduction on the Earthworm Eisenia fetida Tested in Artificial Soil with 5%
Peat. Project Number: M/295080/01/2/OCR, LRT/RG/R/37/07, E/312/3357/4.
Unpublished study prepared by Bayer CropScience. 45 p.

Non-Guideline Study

MRU)

Citation Reference

47443200 Bayer CropScience (2008) Submission of Product Chemistry, Environmental
Fate, Toxicity, Risk and Exposure and Residue Data in Support of the
Application for Registration of BCS-AA10717 Technical Herbicide. Transmittal
of 98 of 120 Studies.

47443300 Bayer CropScience (2008) Submission of Product Chemistry, Environmental
Fate, Toxicity, Risk and Exposure and Residue Data in Support of the
Application for Registration of BCS-AA10717 Technical Herbicide. Transmittal
of 22 of 120 Studies.

103

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47443314	Milius, A. D.; Hoss, H. (2008) BCS-AA10365: A Special Study to Evaluate
Sexual Maturation in Female Wistar Rats. Project Number: M/303774/01/1,
201880, 07/R12/KR. Unpublished study prepared by Bayer CropScience. 173 p.

47443315	Milius, A. D.; Hoss, H. (2008) Technical Grade BCS-AA10717: A Dose Range-
Finding Reproductive Toxicity Study in the Wistar Rat. Project Number:
M/303770/01/1, 201879, 06/P72/GF. Unpublished study prepared by Bayer
CropScience. 387 p.

47443316	Fischer, D. R. (2008) AE 1170437 20 WP - Determination of Transferable
Residues from Turf. Project Number: M/303025/02/1, RADHP025/1.
Unpublished study prepared by Bayer CropScience. 191 p.

47443317	Heintzelman, R.; Lantz, J.; Lunchick, C.; et al. (2008) Human Health Risk
Assessment for the Herbicide BCS-AA10717 (AE 1170437) for Selective
(Residential Turf and Ornamentals) and Non-Selective Broadleaf Weed Control.
Project Number: M/304602/01/1, G201899. Unpublished study prepared by
Bayer Cropscience LP. 54 p.

47443318	Heintzelmann, R.; Ortego, L.; Ramanarayanan, T.; et al. (2008) Ecological Risk
Assessment for the Herbicide BCS-AA10717 (AE 1170437) for Selective
(Residential Turf and Ornamentals) and Non-Selective Broadleaf Weed Control.
Project Number: M/304607/01/1, G201900. Unpublished study prepared by
Bayer Cropscience LP. 55 p.

47443319	Young, B. (2008) Assessment of the Non-Dietary Exposure to BCS-AA10717
Resulting From Use on Residential Turf and Ornamentals in the United States.
Project Number: M/304394/01/1, G201898. Unpublished study prepared by
Bayer Cropscience LP. 26 p.

47443320	Ramanarayanan, T. (2008) Aquatic Ecological Exposure Assessment for BCS-
AA10717 Resulting From Use on Residential Turf and Landscaping, Golf
Course Turf, Forestry and Christmas Tree Farm. Project Number:
M/303428/01/1, MEDHP050/1. Unpublished study prepared by Bayer
CropScience. 79 p.

47443321	Ramanarayanan, T. (2008) Drinking Water Exposure and Risk Assessment for
BCS-AA10717 Resulting From Use on Redidential Turf and Landscaping, Golf
Course Turf, Forestry and Christmas Tree Farm. Project Number:
M/303435/01/1, MEDHP050/2. Unpublished study prepared by Bayer
CropScience. 85 p.

47488700 Bayer Environmental Science (2008) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717 2
MUP Herbicide. Transmittal of 7 Studies.

47488800 Bayer Environmental Science (2008) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717
20 percent WSP Herbicide. Transmittal of 7 Studies.

104

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47488900 Bayer Environmental Science (2008) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717
0.0284% Plus Turf Fertilizer Herbicide. Transmittal of 3 Studies.

47489000 Bayer Environmental Science (2008) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717
0.0213% Plus Turf Fertilizer Herbicide. Transmittal of 2 Studies.

47489100 Bayer Environmental Science (2008) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717
0.0142 percent Plus Turf Fertilizer Herbicide. Transmittal of 2 Studies.

47489200 Bayer Environmental Science (2008) Submission of Product Chemistry and
Toxicity Data in Support of the Application for Registration of Lawn 3FL
Herbicide Granule. Transmittal of 7 Studies.

47489300 Bayer CropScience (2008) Submission of Product Chemistry and Toxicity Data
in Support of the Application for Registration of BCS-AA10717: Bayer
Advanced Lawn 3FL Herbicide Concentrate/RTS. Transmittal of 7 Studies.

47489400 Bayer Advanced (2008) Submission of Product Chemistry and Toxicity Data in
Support of the Application for Registration of BCS-AA10717 Lawn 3FL
Herbicide Ready-to-Use. Transmittal of 2 Studies.

47743300 Bayer CropScience (2009) Submission of Toxicity, Residue, Environmental

Fate, and Exposure and Risk Data in Support of the Application for Registration
of Indaziflam Technical Herbicide. Transmittal of 29 Studies.

47743306 Hubbard, P.; Beavers, J. (2008) BCS-AA10717 Technical: An Acute Oral
Toxicity Study with the Zebra Finch (Poephila guttata) Using a Sequential
Testing Procedure. Project Number: M/318841/Ol/l/OCR, EBDHP029,

149/215. Unpublished study prepared by Wildlife International, Ltd. 42 p.

47743317 Ortego, L.; Tang, J.; Mislankar, S.; et al. (2009) Ecological Risk Assessment for
the Herbicide Indaziflam (BCS-AA10717) for Selective and Non-Selective
Broadleaf Weed Control in Tree, Nut and Vine Crops, Turf and Industrial
Vegetation Management Uses. Project Number: M/348677/Ol/l/OCR,

G202057. Unpublished study prepared by Bayer CropScience. 63 p.

47743400 Bayer CropScience (2009) Submission of Residue,Toxicity, Efficacy, and
Exposure and Risk Data in Support of the Applications for Registration of
Indaziflam 200 SC Herbicide, Indaziflam 500 SC Herbicide, Esplanade SC
Herbicide and Esplanade F Herbicide, and the Petition for Tolerance of
Indaziflam for Use on Sugarcane, Tree Nuts and Vine Crops. Transmittal of 29
Studies.

47743421 Nguyen, T. (2009) Validation of Bayer CropScience Method DH-007-A09-01
Analytical Method for the Determination of Indaziflam and AE 1170437-
Diaminotriazine Residues in Biota. Project Number: M/346444/01/1,
RADHP077, M/34644/01/1/OCR. Unpublished study prepared by Bayer

105

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CropScience. 56 p.

47743422	Desmarteau, D.; Tang, J. (2009) Drinking Water Exposure Assessment for
Indaziflam (BCS-AA10717) Resulting from Use on Fruits, Tree Nuts and
Industrial Vegetative Management. Project Number: M/348691/01/1,
MEDHP067, M/348691/Ol/l/OCR. Unpublished study prepared by Bayer
CropScience. 87 p.

47743423	Tang, Z. (2008) Drinking Water Exposure Assessment for Indaziflam (BCS-
AA10717) Resulting from Use on Fruits and Tree Nuts in Canada. Project
Number: M/348055/01/1, MEDHP075, M/348055/01/1/OCR. Unpublished
study prepared by Bayer CropScience. 83 p.

47743424	Tang, Z. (2008) Aquatic Ecological Exposure Assessment for Indaziflam (BCS-
AA10717) Resulting from Use on Fruits, Tree Nuts, and Industrial Vegetative
Management. Project Number: M/348057/01/1, MEDHP076,
M/348057/01/1/OCR. Unpublished study prepared by Bayer CropScience. 72 p.

47743427	Lantz, J.; Young, B. (2009) Aggregate Exposure and Risk Assessments for
Indaziflam Including Food, Drinking Water and Residential Exposure. Project
Number: M/348950/01/1, G202060, M/348950/01/1/OCR. Unpublished study
prepared by Bayer CropScience. 35 p.

47743428	Sargent, D.; Young, B.; Lantz, J.; et al. (2009) Indaziflam (BCS-AA 10717) and
its Metabolite Fluoroethyl Diaminotriazine (FDAT) Considerations for Human
Health Risk Assessment. Project Number: M/348948/01/1, G202059,
M/348948/Ol/l/OCR. Unpublished study prepared by Bayer CropScience. 26 p.

47743429	Heintzelman, R.; Lantz, J.; Mislankar, S.; et al. (2009) Human Health Risk
Assessment for the Herbicide Indaziflam (BCS-AA 10717) for Selective and
Non-Selective Broadleaf Weed Control in Tree, Nut and Vine Crops and
Industrial Vegetation Management. Project Number: M/349203/01/1, G202056,
G202056/OCR. Unpublished study prepared by Bayer CropScience. 60 p.

47743500 Bayer CropScience (2009) Submission of Product Chemistry and Toxicity Data
in Support of the Applications for Registration of Indiziflam 200 SC Herbicide,
Indaziflam 500 SC Herbicide, Esplanade SC Herbicide and Esplanade F
Herbicide, and the Petition for Tolerance of Indaziflam for Use on Trees, Nuts,
Vine Crops and Sugarcane. Transmittal of 2 Studies.

47743600 Bayer CropScience LP (2009) Submission of Product Chemistry and Toxicity
Data in Support of the Application for Registration of Indaziflam 500 SC
Herbicide. Transmittal of 7 Studies.

47753300 Bayer Environmental Science (2009) Submission of Product Chemistry and

Toxicity Data in Support of the Application for Registration of BCS-AA10717
Technical Herbicide. Transmittal of 14 Studies.

47758400 Bayer CropScience LP (2009) Submission of Toxicity Data in Support of the
FIFRA 6(a)(2) Data Requirements for Amitrole. Transmittal of 1 Study.

106

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47758401 Neuberger, J.; Graves, L.; Doull, J.; et al. (2009) Thyroid Cancer Investigation
at the Bayer CropScience Facility in Stillwell, Kansas. Project Number:
G202055. Unpublished study prepared by University of Kansas School of
Medicine. 22 p.

47792900	Bayer Environmental Science (2009) Submission of Public Interest Data in
Support of the Application for Registration of BCS-AA10717 Technical
Herbicide. Transmittal of 1 Study.

47792901	Bradley, M.; Gorrell, R.; Heintzelman, R.; et al. (2009) Public Interest
Document Supporting the Registration of the Herbicide Indaziflam (BCS-
AA10717) for Selective (Residential Turf and Ornamentals) and Non-Selective
Broadleaf Weed Control. Project Number: G202072. Unpublished study
prepared by Bayer CropScience LP. 42 p.

47793400	Bayer Environmental Science (2009) Submission of Environmental Fate Data in
Support of the Application for Registration of BCS-AA10717 Technical
Herbicide. Transmittal of 1 Study.

47793401	Mislankar, S. (2009) Supplemental Information on Foreign Soils Used in the
Aerobic Soil Metabolism Study (BCS-AA10717 Technical Herbicide).
Unpublished study prepared by Bayer CropScience LP. 9 p.

47889200	Bayer Environmental Science (2009) Submission of Efficacy and Economic
Data in Support of the Application for Registration of Indaziflam Herbicide.
Transmittal of 1 Study.

47889201	Bradley, M.; Gorrell, R.; Heintzelman, R.; et al. (2009) Additional Justification
for the Indaziflam Registration. Project Number: G202102. Unpublished study
prepared by Bayer CropScience. 18 p.

47935700	Bayer Environmental Science (2009) Submission of Product Chemistry Data in
Support of the Amended Registration of BCS-AA10717 Technical Herbicide.
Transmittal of 1 Study.

47935701	Schneider, K. (2009) Indaziflam Technical Material Manufactured by BCS:
Justification of the Technical Grade Active Substance Specification. Project
Number: BCS/AA10717. Unpublished study prepared by Bayer CropScience
AG. 11 p.

107

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