The Detroit Children's Health Study: An Examination of the Effects of Ambient Air Exposure on the Respiratory Health of Asthmatic Children Ann Houston Williams1, Gina Lisa Andrews1, Shaibal Mukerjee2, Lucas Neas 1ORD/NHEERL/ Human Studies Division (HSD)/EBB 2ORD/NERL/Human Exposure and Atmospheric Sciences Division (HEASD) Exposures Mobile Source Emissions • Local car and truck traffic • Interstate traffic • International border crossings Urban Air Toxics • Manganese • Volatile Organic Compounds • Other Air Toxics from Industrial Sources J Exposure Monitoring Late summer of 2005 Four one-week periods at 25 schools Nitrogen dioxide • Ogawa passive samplers Volatile Organic Compounds • Carbopack X passive samplers • Petroleum and process-related compounds Particulate Matter • Wagner-Leith Passive Aerosol Samplers • SEM analysis of metals for source apportionment Exposure Assessment Exposure Model Neighborhood Estimates Questions to be Addressed: •How do urban air pollution levels differ from neighborhood-to-neighborhood? •Are ambient pollutant exposures reflected in clinical / biological markers of exposure? •Are exposure biomarkers predictive of differences in biomarkers of early effect? •What role do neighborhood differences in urban air pollutants play in the development of allergies and asthma? Nested Research Studies GIS Exposure Variables Measures Point 1 Exposure Biomarkers Detroit Children's Health Study School-based Health Data Collection • Questionnaires (Parental-Report) • 15,000 children • Asthma and wheeze-related symptoms • Home environment (molds / pests / ETS) • Examinations (In-school subset) • Lung function 3,500 children • Exhaled nitric oxide 2,000 children Study Participants Public schools Detroit and Dearborn 60 selected elementary schools 4th and 5th grade students Parents and guardians <$"/ % dams): V—/ 11 AM DPS] Study Schedule Community Involvement Exposure Measures Exposure Modeling uestionnaire | Lung ~ I Biomarkers (MICA) X 2004 2005 2006 2007 iro 10 io !Cn ------- |